SIMILAR PATTERNS OF AMINO ACIDS FOR 2IZQ_C_DVAC8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 VAL A  59
TRP A  57
VAL A  22
 None
 0.84A 2izqC-1bf2A:
undetectable
2izqD-1bf2A:
undetectable		 2izqC-1bf2A:
2.38
2izqD-1bf2A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		3 VAL A 205
TRP A 168
VAL A 164
 None
 0.78A 2izqC-1g38A:
undetectable
2izqD-1g38A:
undetectable		 2izqC-1g38A:
5.10
2izqD-1g38A:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		3 VAL A 367
TRP A 429
VAL A 377
 None
 0.88A 2izqC-1gq1A:
undetectable
2izqD-1gq1A:
undetectable		 2izqC-1gq1A:
2.64
2izqD-1gq1A:
2.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		3 VAL A 139
TRP A 158
VAL A 116
 None
 0.90A 2izqC-1hixA:
undetectable
2izqD-1hixA:
undetectable		 2izqC-1hixA:
8.86
2izqD-1hixA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		3 VAL A1665
TRP A1656
VAL A1652
 None
 0.83A 2izqC-1iahA:
undetectable
2izqD-1iahA:
undetectable		 2izqC-1iahA:
6.88
2izqD-1iahA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id2 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		3 VAL A  22
TRP A  46
VAL A  24
 None
 0.83A 2izqC-1id2A:
undetectable
2izqD-1id2A:
undetectable		 2izqC-1id2A:
8.89
2izqD-1id2A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		3 VAL A   8
TRP A 348
VAL A  19
 None
None
CA  A 914 (-4.2A)
 0.77A 2izqC-1lwhA:
undetectable
2izqD-1lwhA:
undetectable		 2izqC-1lwhA:
7.03
2izqD-1lwhA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		3 VAL A  34
TRP A  80
VAL A  32
 None
 0.91A 2izqC-1mbmA:
undetectable
2izqD-1mbmA:
undetectable		 2izqC-1mbmA:
12.94
2izqD-1mbmA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 VAL A 797
TRP A 689
VAL A 763
 None
 0.84A 2izqC-1ogyA:
undetectable
2izqD-1ogyA:
undetectable		 2izqC-1ogyA:
5.19
2izqD-1ogyA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9s REPLICASE
POLYPROTEIN 1AB

(Human
coronavirus
229E) 		PF05409
(Peptidase_C30) 		3 VAL A  17
TRP A  31
VAL A  36
 None
 0.95A 2izqC-1p9sA:
undetectable
2izqD-1p9sA:
undetectable		 2izqC-1p9sA:
7.64
2izqD-1p9sA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		3 VAL A  52
TRP A  39
VAL A  38
 None
ACT  A1180 ( 3.3A)
FMN  A1179 (-4.0A)
 0.98A 2izqC-1uscA:
undetectable
2izqD-1uscA:
undetectable		 2izqC-1uscA:
8.39
2izqD-1uscA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		3 VAL A 702
TRP A 328
VAL A 704
 VAL  A 702 ( 0.5A)
TRP  A 328 ( 0.5A)
VAL  A 704 ( 0.6A)
 0.98A 2izqC-1v0fA:
undetectable
2izqD-1v0fA:
undetectable		 2izqC-1v0fA:
3.41
2izqD-1v0fA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg4 HYPOTHETICAL PROTEIN
(RIKEN CDNA
6030486K23)

(Mus musculus) 		PF00076
(RRM_1) 		3 VAL A  55
TRP A  29
VAL A  47
 None
 0.77A 2izqC-1wg4A:
undetectable
2izqD-1wg4A:
undetectable		 2izqC-1wg4A:
9.88
2izqD-1wg4A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4c SPLICING FACTOR,
ARGININE/SERINE-RICH
1

(Mus musculus) 		PF00076
(RRM_1) 		3 VAL A  55
TRP A  29
VAL A  47
 None
 0.85A 2izqC-1x4cA:
undetectable
2izqD-1x4cA:
undetectable		 2izqC-1x4cA:
20.59
2izqD-1x4cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5c PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 VAL A  61
TRP A  47
VAL A   9
 None
 0.97A 2izqC-1x5cA:
undetectable
2izqD-1x5cA:
undetectable		 2izqC-1x5cA:
10.96
2izqD-1x5cA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		3 VAL A   8
TRP A   6
VAL A  38
 None
 0.85A 2izqC-1zryA:
undetectable
2izqD-1zryA:
undetectable		 2izqC-1zryA:
8.33
2izqD-1zryA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csp RIM BINDING PROTEIN
2

(Homo sapiens) 		no annotation 3 VAL A  26
TRP A  39
VAL A  24
 None
 0.89A 2izqC-2cspA:
undetectable
2izqD-2cspA:
undetectable		 2izqC-2cspA:
8.04
2izqD-2cspA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edf OBSCURIN

(Homo sapiens) 		PF07679
(I-set) 		3 VAL A  66
TRP A  41
VAL A  56
 None
 0.96A 2izqC-2edfA:
undetectable
2izqD-2edfA:
undetectable		 2izqC-2edfA:
8.60
2izqD-2edfA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo1 CDNA FLJ14124 FIS,
CLONE MAMMA1002498

(Homo sapiens) 		PF07679
(I-set) 		3 VAL A  69
TRP A  44
VAL A  59
 None
 0.94A 2izqC-2eo1A:
undetectable
2izqD-2eo1A:
undetectable		 2izqC-2eo1A:
11.36
2izqD-2eo1A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt2 GDP-MANNOSE MANNOSYL
HYDROLASE

(Escherichia
coli) 		PF00293
(NUDIX) 		3 VAL A  48
TRP A  46
VAL A 141
 None
 0.96A 2izqC-2gt2A:
undetectable
2izqD-2gt2A:
undetectable		 2izqC-2gt2A:
7.58
2izqD-2gt2A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA

(Homo sapiens) 		PF00046
(Homeobox)
PF04814
(HNF-1_N) 		3 VAL A 140
TRP A 171
VAL A 142
 None
 0.93A 2izqC-2h8rA:
undetectable
2izqD-2h8rA:
undetectable		 2izqC-2h8rA:
5.69
2izqD-2h8rA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if6 HYPOTHETICAL PROTEIN
YIIX

(Escherichia
coli) 		PF05708
(Peptidase_C92) 		3 VAL A  87
TRP A  19
VAL A 193
 None
 0.71A 2izqC-2if6A:
undetectable
2izqD-2if6A:
undetectable		 2izqC-2if6A:
8.27
2izqD-2if6A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		3 VAL A 194
TRP A 134
VAL A 170
 None
 0.92A 2izqC-2j7cA:
undetectable
2izqD-2j7cA:
undetectable		 2izqC-2j7cA:
2.35
2izqD-2j7cA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnw DNA EXCISION REPAIR
PROTEIN ERCC-1

(Homo sapiens) 		PF03834
(Rad10) 		3 VAL A 112
TRP A 121
VAL A 116
 None
 0.99A 2izqC-2jnwA:
undetectable
2izqD-2jnwA:
undetectable		 2izqC-2jnwA:
7.50
2izqD-2jnwA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jw4 CYTOPLASMIC PROTEIN
NCK1

(Homo sapiens) 		PF00018
(SH3_1) 		3 VAL A  11
TRP A  33
VAL A   9
 None
 0.87A 2izqC-2jw4A:
undetectable
2izqD-2jw4A:
undetectable		 2izqC-2jw4A:
21.43
2izqD-2jw4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jw4 CYTOPLASMIC PROTEIN
NCK1

(Homo sapiens) 		PF00018
(SH3_1) 		3 VAL A  44
TRP A  33
VAL A   9
 None
 0.72A 2izqC-2jw4A:
undetectable
2izqD-2jw4A:
undetectable		 2izqC-2jw4A:
21.43
2izqD-2jw4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7s SERINE/ARGININE-RICH
SPLICING FACTOR 1

(Homo sapiens) 		PF00076
(RRM_1) 		3 VAL A  55
TRP A  29
VAL A  47
 None
 0.79A 2izqC-2m7sA:
undetectable
2izqD-2m7sA:
undetectable		 2izqC-2m7sA:
8.89
2izqD-2m7sA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2miz M04 IMMUNOEVASIN

(Murid
betaherpesvirus
1) 		PF12216
(m04gp34like) 		3 VAL A  64
TRP A  62
VAL A  71
 None
 0.78A 2izqC-2mizA:
undetectable
2izqD-2mizA:
undetectable		 2izqC-2mizA:
6.94
2izqD-2mizA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE

(Macaca
fascicularis) 		PF01408
(GFO_IDH_MocA) 		3 VAL X1067
TRP X1005
VAL X1031
 None
 0.84A 2izqC-2o4uX:
undetectable
2izqD-2o4uX:
undetectable		 2izqC-2o4uX:
3.08
2izqD-2o4uX:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		3 VAL A 264
TRP A 213
VAL A 217
 None
 0.83A 2izqC-2phkA:
undetectable
2izqD-2phkA:
undetectable		 2izqC-2phkA:
4.42
2izqD-2phkA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 VAL A 725
TRP A 422
VAL A 735
 None
 0.80A 2izqC-2pi5A:
undetectable
2izqD-2pi5A:
undetectable		 2izqC-2pi5A:
2.26
2izqD-2pi5A:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE

(Xanthomonas
campestris) 		PF13419
(HAD_2) 		3 VAL A 192
TRP A 201
VAL A 182
 None
 0.95A 2izqC-2pkeA:
undetectable
2izqD-2pkeA:
undetectable		 2izqC-2pkeA:
5.32
2izqD-2pkeA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 3 VAL A  91
TRP A  89
VAL A  84
 None
 0.98A 2izqC-2quaA:
undetectable
2izqD-2quaA:
undetectable		 2izqC-2quaA:
2.55
2izqD-2quaA:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		3 VAL A 117
TRP A 120
VAL A 119
 None
 0.56A 2izqC-2x66A:
undetectable
2izqD-2x66A:
undetectable		 2izqC-2x66A:
5.63
2izqD-2x66A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME

(Candida
albicans) 		PF09084
(NMT1) 		3 VAL A 192
TRP A 190
VAL A  82
 None
 0.87A 2izqC-2x7qA:
undetectable
2izqD-2x7qA:
undetectable		 2izqC-2x7qA:
4.97
2izqD-2x7qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE

(Synechococcus
sp. WH 8020) 		PF05996
(Fe_bilin_red) 		3 VAL A  83
TRP A  52
VAL A  54
 None
 0.77A 2izqC-2x9oA:
undetectable
2izqD-2x9oA:
undetectable		 2izqC-2x9oA:
8.33
2izqD-2x9oA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 463
TRP A 411
VAL A 415
 None
 0.79A 2izqC-2xk9A:
undetectable
2izqD-2xk9A:
undetectable		 2izqC-2xk9A:
4.68
2izqD-2xk9A:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 VAL A 473
TRP A 456
VAL A 435
 None
 0.98A 2izqC-2y3aA:
undetectable
2izqD-2y3aA:
undetectable		 2izqC-2y3aA:
1.45
2izqD-2y3aA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuz MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		3 VAL A  64
TRP A  39
VAL A  54
 None
 0.98A 2izqC-2yuzA:
undetectable
2izqD-2yuzA:
undetectable		 2izqC-2yuzA:
8.54
2izqD-2yuzA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		3 VAL A  42
TRP A  66
VAL A  75
 None
 0.64A 2izqC-2z8eA:
undetectable
2izqD-2z8eA:
undetectable		 2izqC-2z8eA:
2.70
2izqD-2z8eA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		3 VAL A   3
TRP A 178
VAL A 229
 None
 0.89A 2izqC-3aquA:
undetectable
2izqD-3aquA:
undetectable		 2izqC-3aquA:
4.41
2izqD-3aquA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		3 VAL A 309
TRP A 338
VAL A 317
 None
 0.85A 2izqC-3azqA:
undetectable
2izqD-3azqA:
undetectable		 2izqC-3azqA:
2.05
2izqD-3azqA:
2.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beg SPLICING FACTOR,
ARGININE/SERINE-RICH
1

(Homo sapiens) 		PF00076
(RRM_1) 		3 VAL B 160
TRP B 134
VAL B 152
 None
 0.93A 2izqC-3begB:
undetectable
2izqD-3begB:
undetectable		 2izqC-3begB:
22.86
2izqD-3begB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 253
TRP A 203
VAL A 207
 None
 0.74A 2izqC-3c0iA:
undetectable
2izqD-3c0iA:
undetectable		 2izqC-3c0iA:
4.76
2izqD-3c0iA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5m OLIGOGALACTURONATE
LYASE

(Vibrio
parahaemolyticus) 		PF14583
(Pectate_lyase22) 		3 VAL A 116
TRP A 130
VAL A  98
 None
 0.93A 2izqC-3c5mA:
undetectable
2izqD-3c5mA:
undetectable		 2izqC-3c5mA:
4.98
2izqD-3c5mA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		3 VAL A  22
TRP A  46
VAL A  24
 None
 0.90A 2izqC-3c75A:
undetectable
2izqD-3c75A:
undetectable		 2izqC-3c75A:
8.89
2izqD-3c75A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		3 VAL A  46
TRP A  77
VAL A  66
 None
 0.97A 2izqC-3da8A:
undetectable
2izqD-3da8A:
undetectable		 2izqC-3da8A:
5.12
2izqD-3da8A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A1228
TRP A1187
VAL A1191
 None
 0.78A 2izqC-3dlsA:
undetectable
2izqD-3dlsA:
undetectable		 2izqC-3dlsA:
4.83
2izqD-3dlsA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 3 VAL A  73
TRP A  71
VAL A  64
 None
 0.75A 2izqC-3dsmA:
undetectable
2izqD-3dsmA:
undetectable		 2izqC-3dsmA:
6.62
2izqD-3dsmA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2

(Schizosaccharomyces
pombe) 		PF04045
(P34-Arc) 		3 VAL D 244
TRP D 170
VAL D 179
 None
 0.95A 2izqC-3dwlD:
undetectable
2izqD-3dwlD:
undetectable		 2izqC-3dwlD:
5.58
2izqD-3dwlD:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		3 VAL A 257
TRP A 206
VAL A 210
 None
 0.68A 2izqC-3dxnA:
undetectable
2izqD-3dxnA:
undetectable		 2izqC-3dxnA:
5.49
2izqD-3dxnA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 VAL A 103
TRP A 140
VAL A 124
 None
 0.92A 2izqC-3e77A:
undetectable
2izqD-3e77A:
undetectable		 2izqC-3e77A:
6.25
2izqD-3e77A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec9 UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Burkholderia
thailandensis) 		PF12680
(SnoaL_2) 		3 VAL A 116
TRP A 114
VAL A  89
 None
 0.80A 2izqC-3ec9A:
undetectable
2izqD-3ec9A:
undetectable		 2izqC-3ec9A:
8.55
2izqD-3ec9A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 VAL A 348
TRP A 424
VAL A 101
 None
 0.95A 2izqC-3fedA:
undetectable
2izqD-3fedA:
undetectable		 2izqC-3fedA:
1.78
2izqD-3fedA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		3 VAL A  41
TRP A  38
VAL A  37
 None
 0.73A 2izqC-3fz0A:
undetectable
2izqD-3fz0A:
undetectable		 2izqC-3fz0A:
7.69
2izqD-3fz0A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0q A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD)
PF14815
(NUDIX_4) 		3 VAL A  92
TRP A  40
VAL A  41
 None
 0.95A 2izqC-3g0qA:
undetectable
2izqD-3g0qA:
undetectable		 2izqC-3g0qA:
7.14
2izqD-3g0qA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		3 VAL A 284
TRP A 304
VAL A 291
 None
EDO  A   7 (-3.9A)
None
 0.82A 2izqC-3hbcA:
undetectable
2izqD-3hbcA:
undetectable		 2izqC-3hbcA:
4.37
2izqD-3hbcA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 VAL A 310
TRP A 259
VAL A 263
 None
 0.68A 2izqC-3hztA:
undetectable
2izqD-3hztA:
undetectable		 2izqC-3hztA:
3.29
2izqD-3hztA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		3 VAL A 463
TRP A 411
VAL A 415
 None
 0.87A 2izqC-3i6uA:
undetectable
2izqD-3i6uA:
undetectable		 2izqC-3i6uA:
3.30
2izqD-3i6uA:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3

(Saccharomyces
cerevisiae) 		PF06544
(DUF1115)
PF08572
(PRP3) 		3 VAL K 383
TRP K 428
VAL K 341
 None
 0.99A 2izqC-3jcmK:
undetectable
2izqD-3jcmK:
undetectable		 2izqC-3jcmK:
2.73
2izqD-3jcmK:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		3 VAL A 235
TRP A 180
VAL A 312
 None
 0.92A 2izqC-3kl9A:
undetectable
2izqD-3kl9A:
undetectable		 2izqC-3kl9A:
3.49
2izqD-3kl9A:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		3 VAL A  17
TRP A 311
VAL A  19
 None
 0.88A 2izqC-3l12A:
undetectable
2izqD-3l12A:
undetectable		 2izqC-3l12A:
5.05
2izqD-3l12A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		3 VAL A 490
TRP A  23
VAL A 521
 None
 0.99A 2izqC-3n2oA:
undetectable
2izqD-3n2oA:
undetectable		 2izqC-3n2oA:
3.11
2izqD-3n2oA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9t NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 VAL A 192
TRP A 203
VAL A 194
 None
 0.99A 2izqC-3o9tA:
undetectable
2izqD-3o9tA:
undetectable		 2izqC-3o9tA:
8.26
2izqD-3o9tA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		3 VAL A 345
TRP A 343
VAL A 200
 None
 0.94A 2izqC-3os6A:
undetectable
2izqD-3os6A:
undetectable		 2izqC-3os6A:
5.13
2izqD-3os6A:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		3 VAL A 103
TRP A 101
VAL A  93
 None
 0.92A 2izqC-3q6tA:
undetectable
2izqD-3q6tA:
undetectable		 2izqC-3q6tA:
3.40
2izqD-3q6tA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		3 VAL A 192
TRP A 190
VAL A 214
 None
 0.80A 2izqC-3qs1A:
undetectable
2izqD-3qs1A:
undetectable		 2izqC-3qs1A:
12.82
2izqD-3qs1A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uem PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		3 VAL A 421
TRP A 407
VAL A 369
 None
 0.98A 2izqC-3uemA:
undetectable
2izqD-3uemA:
undetectable		 2izqC-3uemA:
3.50
2izqD-3uemA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		3 VAL A  40
TRP A  43
VAL A  59
 None
 0.96A 2izqC-3wfoA:
undetectable
2izqD-3wfoA:
undetectable		 2izqC-3wfoA:
4.26
2izqD-3wfoA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		3 VAL A  40
TRP A  43
VAL A  59
 None
 0.97A 2izqC-3wfpA:
undetectable
2izqD-3wfpA:
undetectable		 2izqC-3wfpA:
2.75
2izqD-3wfpA:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		3 VAL A  41
TRP A  50
VAL A 314
 None
 0.90A 2izqC-3wvsA:
undetectable
2izqD-3wvsA:
undetectable		 2izqC-3wvsA:
6.22
2izqD-3wvsA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqb NEOGENIN

(Mus musculus) 		PF00041
(fn3) 		3 VAL A 994
TRP A1008
VAL A 992
 None
 0.92A 2izqC-4bqbA:
undetectable
2izqD-4bqbA:
undetectable		 2izqC-4bqbA:
6.51
2izqD-4bqbA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsk VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 3

(Homo sapiens) 		no annotation 3 VAL A 193
TRP A 155
VAL A 156
 None
 0.86A 2izqC-4bskA:
undetectable
2izqD-4bskA:
undetectable		 2izqC-4bskA:
6.35
2izqD-4bskA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el1 PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		3 VAL A 421
TRP A 407
VAL A 369
 None
 0.92A 2izqC-4el1A:
undetectable
2izqD-4el1A:
undetectable		 2izqC-4el1A:
3.37
2izqD-4el1A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 VAL A 810
TRP A 808
VAL A 974
 None
 0.95A 2izqC-4f7zA:
undetectable
2izqD-4f7zA:
undetectable		 2izqC-4f7zA:
2.20
2izqD-4f7zA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgu LEGUMAIN

(Homo sapiens) 		PF01650
(Peptidase_C13) 		3 VAL A  32
TRP A  30
VAL A 141
 None
 0.66A 2izqC-4fguA:
undetectable
2izqD-4fguA:
undetectable		 2izqC-4fguA:
2.88
2izqD-4fguA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 VAL A  64
TRP A   4
VAL A  28
 None
 0.94A 2izqC-4koaA:
undetectable
2izqD-4koaA:
undetectable		 2izqC-4koaA:
5.16
2izqD-4koaA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		3 VAL A 215
TRP A 221
VAL A 220
 None
 0.90A 2izqC-4lmvA:
undetectable
2izqD-4lmvA:
undetectable		 2izqC-4lmvA:
9.17
2izqD-4lmvA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzi MULTICYSTATIN

(Solanum
tuberosum) 		PF00031
(Cystatin) 		3 VAL A  77
TRP A 174
VAL A  51
 None
 1.00A 2izqC-4lziA:
undetectable
2izqD-4lziA:
undetectable		 2izqC-4lziA:
4.69
2izqD-4lziA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 VAL E 810
TRP E 808
VAL E 974
 None
 0.99A 2izqC-4mh0E:
undetectable
2izqD-4mh0E:
undetectable		 2izqC-4mh0E:
2.67
2izqD-4mh0E:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qma CYSTEINE DIOXYGENASE
TYPE I

(Cupriavidus
pinatubonensis) 		PF05995
(CDO_I) 		3 VAL A 139
TRP A  99
VAL A  98
 None
EDO  A 308 (-3.9A)
None
 0.64A 2izqC-4qmaA:
undetectable
2izqD-4qmaA:
undetectable		 2izqC-4qmaA:
9.20
2izqD-4qmaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		3 VAL B 207
TRP B 218
VAL B 205
 None
 0.98A 2izqC-4rs1B:
undetectable
2izqD-4rs1B:
undetectable		 2izqC-4rs1B:
2.56
2izqD-4rs1B:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz6 GLYCINE
BETAINE/PROLINE ABC
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF04069
(OpuAC) 		3 VAL A  76
TRP A 281
VAL A  74
 None
 0.98A 2izqC-4xz6A:
undetectable
2izqD-4xz6A:
undetectable		 2izqC-4xz6A:
4.83
2izqD-4xz6A:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		3 VAL A 224
TRP A 163
VAL A 348
 None
 0.91A 2izqC-5dgkA:
undetectable
2izqD-5dgkA:
undetectable		 2izqC-5dgkA:
5.02
2izqD-5dgkA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en2 GD01 HEAVY CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Mus musculus;
Argentinian
mammarenavirus) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		3 VAL C 117
TRP A  33
VAL A  97
 None
 0.82A 2izqC-5en2C:
undetectable
2izqD-5en2C:
undetectable		 2izqC-5en2C:
7.30
2izqD-5en2C:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		3 VAL A 192
TRP A 132
VAL A 168
 None
 0.96A 2izqC-5idiA:
undetectable
2izqD-5idiA:
undetectable		 2izqC-5idiA:
3.05
2izqD-5idiA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idk GENOME
POLYPROTEIN,SERINE
PROTEASE SUBUNIT
NS2B, SERINE
PROTEASE NS3

(West Nile virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		3 VAL A1072
TRP A1005
VAL A1003
 None
 0.72A 2izqC-5idkA:
undetectable
2izqD-5idkA:
undetectable		 2izqC-5idkA:
10.89
2izqD-5idkA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 3 VAL D 189
TRP D 187
VAL D 117
 None
 0.91A 2izqC-5k59D:
undetectable
2izqD-5k59D:
undetectable		 2izqC-5k59D:
4.52
2izqD-5k59D:
4.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		3 VAL A  92
TRP A  40
VAL A  41
 None
 0.94A 2izqC-5kn8A:
undetectable
2izqD-5kn8A:
undetectable		 2izqC-5kn8A:
32.26
2izqD-5kn8A:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 812
TRP A 762
VAL A 766
 None
 0.71A 2izqC-5lohA:
undetectable
2izqD-5lohA:
undetectable		 2izqC-5lohA:
5.49
2izqD-5lohA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lub LEGUMAIN

(Homo sapiens) 		no annotation 3 VAL B  32
TRP B  30
VAL B 141
 None
 0.69A 2izqC-5lubB:
undetectable
2izqD-5lubB:
undetectable		 2izqC-5lubB:
4.33
2izqD-5lubB:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Escherichia
coli) 		PF01977
(UbiD) 		3 VAL A 381
TRP A 386
VAL A 385
 None
 0.90A 2izqC-5m1bA:
undetectable
2izqD-5m1bA:
undetectable		 2izqC-5m1bA:
3.01
2izqD-5m1bA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4k NUCLEOPROTEIN

(Human
coronavirus
NL63) 		PF00937
(Corona_nucleoca) 		3 VAL A  58
TRP A  56
VAL A  99
 None
 0.91A 2izqC-5n4kA:
undetectable
2izqD-5n4kA:
undetectable		 2izqC-5n4kA:
6.12
2izqD-5n4kA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh0 REPLICASE
POLYPROTEIN 1AB

(Human
coronavirus
NL63) 		no annotation 3 VAL A  17
TRP A  31
VAL A  36
 None
 0.99A 2izqC-5nh0A:
undetectable
2izqD-5nh0A:
undetectable		 2izqC-5nh0A:
undetectable
2izqD-5nh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0s RNA POLYMERASE II
SUBUNIT RPB6

(Schizosaccharomyces
pombe) 		PF04934
(Med6) 		3 VAL f 138
TRP f 136
VAL f 124
 None
 0.95A 2izqC-5u0sf:
undetectable
2izqD-5u0sf:
undetectable		 2izqC-5u0sf:
8.03
2izqD-5u0sf:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wox UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 3 VAL A  94
TRP A  92
VAL A  79
 None
 0.54A 2izqC-5woxA:
undetectable
2izqD-5woxA:
undetectable		 2izqC-5woxA:
undetectable
2izqD-5woxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 3 VAL A  90
TRP A  88
VAL A  35
 None
 0.77A 2izqC-5x3jA:
undetectable
2izqD-5x3jA:
undetectable		 2izqC-5x3jA:
undetectable
2izqD-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 3 VAL A 340
TRP A 354
VAL A 352
 None
 0.94A 2izqC-5x89A:
undetectable
2izqD-5x89A:
undetectable		 2izqC-5x89A:
undetectable
2izqD-5x89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdm -

(-) 		no annotation 3 VAL A 108
TRP A 106
VAL A 132
 None
 0.70A 2izqC-5zdmA:
undetectable
2izqD-5zdmA:
undetectable		 2izqC-5zdmA:
undetectable
2izqD-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 VAL A1285
TRP A1284
VAL A1218
 None
 0.82A 2izqC-6emkA:
undetectable
2izqD-6emkA:
undetectable		 2izqC-6emkA:
undetectable
2izqD-6emkA:
undetectable