SIMILAR PATTERNS OF AMINO ACIDS FOR 2IZQ_B_DVAB6_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak0 P1 NUCLEASE

(Penicillium
citrinum) 		PF02265
(S1-P1_nuclease) 		3 TRP A  24
ALA A 108
VAL A  97
 None
 0.82A 2izqA-1ak0A:
undetectable
2izqB-1ak0A:
undetectable		 2izqA-1ak0A:
3.85
2izqB-1ak0A:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bii MHC CLASS I H-2DD

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TRP A  97
ALA A  11
VAL A   9
 None
 0.60A 2izqA-1biiA:
undetectable
2izqB-1biiA:
undetectable		 2izqA-1biiA:
3.68
2izqB-1biiA:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8o ICE INHIBITOR

(Cowpox virus) 		PF00079
(Serpin) 		3 TRP A 137
ALA A 293
VAL A 286
 None
 0.82A 2izqA-1c8oA:
undetectable
2izqB-1c8oA:
undetectable		 2izqA-1c8oA:
4.96
2izqB-1c8oA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddh MHC CLASS I H-2DD
HEAVY CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TRP A  97
ALA A  11
VAL A   9
 None
 0.74A 2izqA-1ddhA:
undetectable
2izqB-1ddhA:
undetectable		 2izqA-1ddhA:
4.14
2izqB-1ddhA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 TRP A 976
ALA A 983
VAL A 979
 None
 0.76A 2izqA-1g8xA:
undetectable
2izqB-1g8xA:
undetectable		 2izqA-1g8xA:
1.83
2izqB-1g8xA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		3 TRP A 489
ALA A 349
VAL A 352
 None
 0.85A 2izqA-1j3bA:
undetectable
2izqB-1j3bA:
undetectable		 2izqA-1j3bA:
4.73
2izqB-1j3bA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m93 SERINE PROTEINASE
INHIBITOR 2

(Cowpox virus) 		PF00079
(Serpin) 		3 TRP B 137
ALA B 293
VAL B 286
 None
 0.85A 2izqA-1m93B:
undetectable
2izqB-1m93B:
undetectable		 2izqA-1m93B:
6.79
2izqB-1m93B:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 TRP A   9
ALA A 188
VAL A 190
 None
None
GOL  A 751 (-4.1A)
 0.85A 2izqA-1mqqA:
undetectable
2izqB-1mqqA:
undetectable		 2izqA-1mqqA:
3.46
2izqB-1mqqA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Escherichia
coli) 		no annotation 3 TRP B  63
ALA B  58
VAL B  60
 None
 0.81A 2izqA-1r2kB:
undetectable
2izqB-1r2kB:
undetectable		 2izqA-1r2kB:
6.59
2izqB-1r2kB:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 TRP A  66
ALA A  15
VAL A  17
 None
 0.71A 2izqA-1rblA:
undetectable
2izqB-1rblA:
undetectable		 2izqA-1rblA:
4.08
2izqB-1rblA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		3 TRP A  51
ALA A 129
VAL A 123
 None
 0.59A 2izqA-1sfrA:
undetectable
2izqB-1sfrA:
undetectable		 2izqA-1sfrA:
6.90
2izqB-1sfrA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfs HYPOTHETICAL PROTEIN

(Geobacillus
stearothermophilus) 		PF08924
(DUF1906) 		3 TRP A 189
ALA A 154
VAL A 158
 None
 0.76A 2izqA-1sfsA:
undetectable
2izqB-1sfsA:
undetectable		 2izqA-1sfsA:
7.59
2izqB-1sfsA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 TRP A  34
ALA A  99
VAL A  93
 None
 0.78A 2izqA-1womA:
undetectable
2izqB-1womA:
undetectable		 2izqA-1womA:
18.33
2izqB-1womA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 TRP A  41
ALA A  49
VAL A  44
 None
 0.79A 2izqA-1xjeA:
undetectable
2izqB-1xjeA:
undetectable		 2izqA-1xjeA:
1.74
2izqB-1xjeA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN B1A CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		3 TRP C  16
ALA C  24
VAL C  19
 None
 0.69A 2izqA-1yhuC:
undetectable
2izqB-1yhuC:
undetectable		 2izqA-1yhuC:
5.97
2izqB-1yhuC:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5z HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00271
(Helicase_C) 		3 TRP A 828
ALA A 809
VAL A 807
 None
 0.56A 2izqA-1z5zA:
undetectable
2izqB-1z5zA:
undetectable		 2izqA-1z5zA:
3.82
2izqB-1z5zA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljr GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 TRP A  84
ALA A 158
VAL A 162
 None
 0.80A 2izqA-2ljrA:
undetectable
2izqB-2ljrA:
undetectable		 2izqA-2ljrA:
5.67
2izqB-2ljrA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8p 14-3-3 DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		3 TRP A  23
ALA A  18
VAL A  20
 None
 0.81A 2izqA-2o8pA:
undetectable
2izqB-2o8pA:
undetectable		 2izqA-2o8pA:
5.81
2izqB-2o8pA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 TRP A  91
ALA A  60
VAL A  62
 None
 0.83A 2izqA-2p6rA:
undetectable
2izqB-2p6rA:
undetectable		 2izqA-2p6rA:
2.21
2izqB-2p6rA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B

(Bos taurus) 		PF00400
(WD40) 		3 TRP C 104
ALA C  76
VAL C  78
 None
 0.62A 2izqA-2p9nC:
undetectable
2izqB-2p9nC:
undetectable		 2izqA-2p9nC:
3.52
2izqB-2p9nC:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poi BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF00653
(BIR) 		3 TRP A  73
ALA A  44
VAL A  42
 None
 0.85A 2izqA-2poiA:
undetectable
2izqB-2poiA:
undetectable		 2izqA-2poiA:
8.05
2izqB-2poiA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkq EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF00536
(SAM_1) 		3 TRP A 915
ALA A 963
VAL A 965
 None
 0.84A 2izqA-2qkqA:
undetectable
2izqB-2qkqA:
undetectable		 2izqA-2qkqA:
12.12
2izqB-2qkqA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 TRP A 105
ALA A  83
VAL A  85
 None
 0.79A 2izqA-2vakA:
undetectable
2izqB-2vakA:
undetectable		 2izqA-2vakA:
5.53
2izqB-2vakA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		3 TRP A 112
ALA A 117
VAL A 115
 None
 0.83A 2izqA-2w8qA:
undetectable
2izqB-2w8qA:
undetectable		 2izqA-2w8qA:
2.88
2izqB-2w8qA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 TRP A  81
ALA A  63
VAL A  65
 None
 0.74A 2izqA-2x05A:
undetectable
2izqB-2x05A:
undetectable		 2izqA-2x05A:
1.74
2izqB-2x05A:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x64 GLUTATHIONE-S-TRANSF
ERASE

(Xylella
fastidiosa) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 TRP A  20
ALA A 191
VAL A 195
 None
 0.79A 2izqA-2x64A:
undetectable
2izqB-2x64A:
undetectable		 2izqA-2x64A:
9.09
2izqB-2x64A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvh TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		3 TRP A  63
ALA A  89
VAL A  92
 None
 0.79A 2izqA-2yvhA:
undetectable
2izqB-2yvhA:
undetectable		 2izqA-2yvhA:
9.65
2izqB-2yvhA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywm GLUTAREDOXIN-LIKE
PROTEIN

(Aquifex
aeolicus) 		PF13192
(Thioredoxin_3) 		3 TRP A 159
ALA A 154
VAL A 156
 None
 0.81A 2izqA-2ywmA:
undetectable
2izqB-2ywmA:
undetectable		 2izqA-2ywmA:
5.23
2izqB-2ywmA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		3 TRP A 218
ALA A 155
VAL A 179
 None
 0.82A 2izqA-3aquA:
undetectable
2izqB-3aquA:
undetectable		 2izqA-3aquA:
4.41
2izqB-3aquA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		3 TRP A 621
ALA A 626
VAL A 624
 LOP  A 810 (-3.6A)
HEM  A 802 (-3.5A)
LOP  A 810 (-4.9A)
 0.85A 2izqA-3ayfA:
undetectable
2izqB-3ayfA:
undetectable		 2izqA-3ayfA:
3.17
2izqB-3ayfA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b12 FLUOROACETATE
DEHALOGENASE

(Burkholderia
sp.) 		PF00561
(Abhydrolase_1) 		3 TRP A 255
ALA A 104
VAL A 126
 None
FAH  A 501 (-3.5A)
None
 0.77A 2izqA-3b12A:
undetectable
2izqB-3b12A:
undetectable		 2izqA-3b12A:
4.66
2izqB-3b12A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv6 METAL-DEPENDENT
HYDROLASE

(Vibrio cholerae) 		PF13483
(Lactamase_B_3) 		3 TRP A 151
ALA A 146
VAL A 148
 None
 0.85A 2izqA-3bv6A:
undetectable
2izqB-3bv6A:
undetectable		 2izqA-3bv6A:
6.07
2izqB-3bv6A:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TRP A  15
ALA A  22
VAL A  18
 None
 0.73A 2izqA-3db2A:
undetectable
2izqB-3db2A:
undetectable		 2izqA-3db2A:
6.75
2izqB-3db2A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		3 TRP C 257
ALA C 234
VAL C 259
 None
 0.78A 2izqA-3degC:
undetectable
2izqB-3degC:
undetectable		 2izqA-3degC:
5.43
2izqB-3degC:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		3 TRP A 505
ALA A 444
VAL A 475
 None
 0.85A 2izqA-3eqnA:
undetectable
2izqB-3eqnA:
undetectable		 2izqA-3eqnA:
2.74
2izqB-3eqnA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE

(Mus musculus) 		no annotation 3 TRP A  91
ALA A  86
VAL A  88
 None
 0.81A 2izqA-3ewiA:
undetectable
2izqB-3ewiA:
undetectable		 2izqA-3ewiA:
12.50
2izqB-3ewiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjg PUTATIVE
ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
COBC

(Vibrio
parahaemolyticus) 		PF00300
(His_Phos_1) 		3 TRP A 131
ALA A 156
VAL A 158
 None
 0.72A 2izqA-3hjgA:
undetectable
2izqB-3hjgA:
undetectable		 2izqA-3hjgA:
8.51
2izqB-3hjgA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibz PUTATIVE TELLURIUM
RESISTANT LIKE
PROTEIN TERD

(Streptomyces
coelicolor) 		PF02342
(TerD) 		3 TRP A 167
ALA A 100
VAL A  98
 None
 0.85A 2izqA-3ibzA:
undetectable
2izqB-3ibzA:
undetectable		 2izqA-3ibzA:
6.55
2izqB-3ibzA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih6 PUTATIVE ZINC
PROTEASE

(Bordetella
pertussis) 		PF05193
(Peptidase_M16_C) 		3 TRP A 382
ALA A 290
VAL A 296
 None
 0.78A 2izqA-3ih6A:
undetectable
2izqB-3ih6A:
undetectable		 2izqA-3ih6A:
9.57
2izqB-3ih6A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv1 P22 PROTEIN

(Trypanosoma
brucei) 		PF02330
(MAM33) 		3 TRP A  79
ALA A 192
VAL A 195
 None
 0.81A 2izqA-3jv1A:
undetectable
2izqB-3jv1A:
undetectable		 2izqA-3jv1A:
5.71
2izqB-3jv1A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3d PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF08448
(PAS_4) 		3 TRP A   7
ALA A  13
VAL A  11
 None
 0.71A 2izqA-3k3dA:
undetectable
2izqB-3k3dA:
undetectable		 2izqA-3k3dA:
13.58
2izqB-3k3dA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		3 TRP A1547
ALA A1422
VAL A1424
 None
 0.77A 2izqA-3k9bA:
undetectable
2izqB-3k9bA:
undetectable		 2izqA-3k9bA:
5.88
2izqB-3k9bA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfl METHIONYL-TRNA
SYNTHETASE

(Leishmania
major) 		PF09334
(tRNA-synt_1g) 		3 TRP A 596
ALA A 695
VAL A 698
 None
 0.83A 2izqA-3kflA:
undetectable
2izqB-3kflA:
undetectable		 2izqA-3kflA:
4.38
2izqB-3kflA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx0 UNCHARACTERIZED
PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF08448
(PAS_4) 		3 TRP X   7
ALA X  13
VAL X  11
 None
 0.84A 2izqA-3kx0X:
undetectable
2izqB-3kx0X:
undetectable		 2izqA-3kx0X:
13.58
2izqB-3kx0X:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 TRP A 104
ALA A 131
VAL A 174
 None
 0.68A 2izqA-3lv4A:
undetectable
2izqB-3lv4A:
undetectable		 2izqA-3lv4A:
2.91
2izqB-3lv4A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcw PUTATIVE HYDROLASE

(Chromobacterium
violaceum) 		PF00857
(Isochorismatase) 		3 TRP A  47
ALA A 118
VAL A 116
 None
 0.72A 2izqA-3mcwA:
undetectable
2izqB-3mcwA:
undetectable		 2izqA-3mcwA:
6.72
2izqB-3mcwA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		3 TRP A 127
ALA A  88
VAL A 246
 None
 0.74A 2izqA-3ppoA:
undetectable
2izqB-3ppoA:
undetectable		 2izqA-3ppoA:
5.46
2izqB-3ppoA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		3 TRP A 172
ALA A 216
VAL A 168
 None
 0.72A 2izqA-3ppoA:
undetectable
2izqB-3ppoA:
undetectable		 2izqA-3ppoA:
5.46
2izqB-3ppoA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 TRP B 757
ALA B 791
VAL B 578
 None
 0.76A 2izqA-3prxB:
undetectable
2izqB-3prxB:
undetectable		 2izqA-3prxB:
1.67
2izqB-3prxB:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		3 TRP A 169
ALA A 196
VAL A 198
 None
 0.69A 2izqA-3s51A:
undetectable
2izqB-3s51A:
undetectable		 2izqA-3s51A:
1.35
2izqB-3s51A:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 TRP A 338
ALA A 329
VAL A 299
 None
 0.71A 2izqA-3sfzA:
undetectable
2izqB-3sfzA:
undetectable		 2izqA-3sfzA:
1.80
2izqB-3sfzA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		3 TRP A  28
ALA A  69
VAL A  72
 None
 0.72A 2izqA-3sz3A:
undetectable
2izqB-3sz3A:
undetectable		 2izqA-3sz3A:
7.19
2izqB-3sz3A:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaj ENVELOPE PROTEIN

(Dengue virus) 		no annotation 3 TRP B  20
ALA B  35
VAL B  15
 None
 0.84A 2izqA-3uajB:
undetectable
2izqB-3uajB:
undetectable		 2izqA-3uajB:
6.42
2izqB-3uajB:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4h HYPOTHETICAL PROTEIN

(Yersinia pestis) 		PF05638
(T6SS_HCP) 		3 TRP A  32
ALA A  35
VAL A  53
 None
 0.77A 2izqA-3v4hA:
undetectable
2izqB-3v4hA:
undetectable		 2izqA-3v4hA:
10.00
2izqB-3v4hA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		3 TRP A 172
ALA A 230
VAL A 232
 None
 0.79A 2izqA-4c90A:
undetectable
2izqB-4c90A:
undetectable		 2izqA-4c90A:
3.20
2izqB-4c90A:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 TRP A 100
ALA A 127
VAL A 170
 TRS  A1471 (-3.5A)
None
TRS  A1471 (-3.9A)
 0.67A 2izqA-4cotA:
undetectable
2izqB-4cotA:
undetectable		 2izqA-4cotA:
6.78
2izqB-4cotA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		3 TRP A  45
ALA A 202
VAL A  48
 None
 0.76A 2izqA-4f53A:
undetectable
2izqB-4f53A:
undetectable		 2izqA-4f53A:
2.62
2izqB-4f53A:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft6 PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 TRP A 361
ALA A 318
VAL A 343
 None
C8E  A 404 ( 4.5A)
C8E  A 404 ( 4.9A)
 0.85A 2izqA-4ft6A:
undetectable
2izqB-4ft6A:
undetectable		 2izqA-4ft6A:
3.39
2izqB-4ft6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		3 TRP A 459
ALA A 467
VAL A 435
 None
 0.81A 2izqA-4g25A:
undetectable
2izqB-4g25A:
undetectable		 2izqA-4g25A:
3.75
2izqB-4g25A:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gox POLYKETIDE SYNTHASE

(Synechococcus
sp. PCC 7002) 		PF13469
(Sulfotransfer_3) 		3 TRP A 107
ALA A 102
VAL A 104
 None
 0.85A 2izqA-4goxA:
undetectable
2izqB-4goxA:
undetectable		 2izqA-4goxA:
9.91
2izqB-4goxA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		3 TRP A 118
ALA A 308
VAL A  37
 None
 0.82A 2izqA-4hpvA:
undetectable
2izqB-4hpvA:
undetectable		 2izqA-4hpvA:
4.56
2izqB-4hpvA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw9 GLUTATHIONE
TRANSFERASE

(Mannheimia
haemolytica) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 TRP A  20
ALA A 194
VAL A 198
 None
 0.76A 2izqA-4iw9A:
undetectable
2izqB-4iw9A:
undetectable		 2izqA-4iw9A:
5.43
2izqB-4iw9A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 TRP A  66
ALA A  15
VAL A  17
 None
 0.80A 2izqA-4mkvA:
undetectable
2izqB-4mkvA:
undetectable		 2izqA-4mkvA:
3.79
2izqB-4mkvA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME

(Saccharomyces
cerevisiae;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF11951
(Fungal_trans_2) 		3 TRP A 732
ALA A 711
VAL A 872
 None
 0.74A 2izqA-4n9nA:
undetectable
2izqB-4n9nA:
undetectable		 2izqA-4n9nA:
3.16
2izqB-4n9nA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 TRP A 351
ALA A 328
VAL A 326
 None
 0.40A 2izqA-4om9A:
undetectable
2izqB-4om9A:
undetectable		 2izqA-4om9A:
1.65
2izqB-4om9A:
1.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP

(Homo sapiens) 		PF00653
(BIR) 		3 TRP A  73
ALA A  44
VAL A  42
 None
 0.76A 2izqA-4oxcA:
undetectable
2izqB-4oxcA:
undetectable		 2izqA-4oxcA:
6.31
2izqB-4oxcA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		3 TRP A  76
ALA A 144
VAL A  80
 None
 0.68A 2izqA-4qjyA:
undetectable
2izqB-4qjyA:
undetectable		 2izqA-4qjyA:
3.34
2izqB-4qjyA:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtt MULTIFUNCTIONAL
METHYLTRANSFERASE
SUBUNIT TRM112

(Saccharomyces
cerevisiae) 		PF03966
(Trm112p) 		3 TRP A  56
ALA A  64
VAL A  59
 None
 0.84A 2izqA-4qttA:
undetectable
2izqB-4qttA:
undetectable		 2izqA-4qttA:
5.83
2izqB-4qttA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		3 TRP A 410
ALA A 358
VAL A 381
 None
 0.78A 2izqA-4u7lA:
undetectable
2izqB-4u7lA:
undetectable		 2izqA-4u7lA:
2.88
2izqB-4u7lA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuo CYTOSOLIC MALATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TRP A 150
ALA A 152
VAL A 124
 None
 0.76A 2izqA-4uuoA:
undetectable
2izqB-4uuoA:
undetectable		 2izqA-4uuoA:
6.80
2izqB-4uuoA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w99 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH, B-SPECIFIC]
1, MITOCHONDRIAL

(Candida
tropicalis) 		no annotation 3 TRP A 132
ALA A  96
VAL A  29
 None
 0.79A 2izqA-4w99A:
undetectable
2izqB-4w99A:
undetectable		 2izqA-4w99A:
5.49
2izqB-4w99A:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		3 TRP A 590
ALA A 598
VAL A 593
 None
 0.84A 2izqA-4xwlA:
undetectable
2izqB-4xwlA:
undetectable		 2izqA-4xwlA:
2.84
2izqB-4xwlA:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgc KELCH PROTEIN

(Plasmodium
falciparum) 		PF01344
(Kelch_1)
PF02214
(BTB_2)
PF13418
(Kelch_4) 		3 TRP A 611
ALA A 557
VAL A 555
 None
 0.83A 2izqA-4zgcA:
undetectable
2izqB-4zgcA:
undetectable		 2izqA-4zgcA:
3.69
2izqB-4zgcA:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 TRP A 374
ALA A 382
VAL A 377
 None
NAG  A1501 (-4.1A)
None
 0.84A 2izqA-5a7mA:
undetectable
2izqB-5a7mA:
undetectable		 2izqA-5a7mA:
1.95
2izqB-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3g PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 TRP B 234
ALA B 393
VAL B 522
 None
 0.74A 2izqA-5b3gB:
undetectable
2izqB-5b3gB:
undetectable		 2izqA-5b3gB:
5.75
2izqB-5b3gB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 TRP B 234
ALA B 393
VAL B 522
 None
 0.70A 2izqA-5b3hB:
undetectable
2izqB-5b3hB:
undetectable		 2izqA-5b3hB:
5.75
2izqB-5b3hB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3j CYTOCHROME B-LARGE
SUBUNIT
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL

(Ascaris suum;
Ascaris suum) 		PF01127
(Sdh_cyt)
PF05328
(CybS) 		3 TRP D 154
ALA C 169
VAL C 171
 EPH  D 201 (-3.7A)
None
None
 0.81A 2izqA-5c3jD:
undetectable
2izqB-5c3jD:
undetectable		 2izqA-5c3jD:
7.28
2izqB-5c3jD:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		3 TRP A 164
ALA A 149
VAL A 154
 None
 0.82A 2izqA-5dacA:
undetectable
2izqB-5dacA:
undetectable		 2izqA-5dacA:
3.93
2izqB-5dacA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		3 TRP A  33
ALA A  98
VAL A  92
 None
 0.74A 2izqA-5dnwA:
undetectable
2izqB-5dnwA:
undetectable		 2izqA-5dnwA:
5.21
2izqB-5dnwA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 TRP B 914
ALA B 933
VAL B 931
 None
 0.81A 2izqA-5fq6B:
undetectable
2izqB-5fq6B:
undetectable		 2izqA-5fq6B:
1.67
2izqB-5fq6B:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		3 TRP A  57
ALA A  53
VAL A  75
 None
 0.82A 2izqA-5g5nA:
undetectable
2izqB-5g5nA:
undetectable		 2izqA-5g5nA:
5.15
2izqB-5g5nA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		3 TRP A 384
ALA A 429
VAL A 380
 DQR  A 544 (-4.1A)
None
None
 0.81A 2izqA-5g5zA:
undetectable
2izqB-5g5zA:
undetectable		 2izqA-5g5zA:
2.85
2izqB-5g5zA:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		3 TRP A 285
ALA A 277
VAL A 282
 None
 0.83A 2izqA-5gz4A:
undetectable
2izqB-5gz4A:
undetectable		 2izqA-5gz4A:
1.90
2izqB-5gz4A:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 3 TRP C 427
ALA C 422
VAL C 424
 None
 0.80A 2izqA-5hr4C:
undetectable
2izqB-5hr4C:
undetectable		 2izqA-5hr4C:
2.72
2izqB-5hr4C:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg STRIGOLACTONE
ESTERASE D14

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		3 TRP A  35
ALA A 100
VAL A  94
 None
 0.79A 2izqA-5hzgA:
undetectable
2izqB-5hzgA:
undetectable		 2izqA-5hzgA:
4.35
2izqB-5hzgA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		3 TRP A  93
ALA A  84
VAL A  82
 None
 0.85A 2izqA-5l9sA:
undetectable
2izqB-5l9sA:
undetectable		 2izqA-5l9sA:
4.09
2izqB-5l9sA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 3 TRP A 133
ALA A  71
VAL A  73
 None
 0.71A 2izqA-5m3xA:
undetectable
2izqB-5m3xA:
undetectable		 2izqA-5m3xA:
undetectable
2izqB-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TRP A 237
ALA A 274
VAL A 270
 None
 0.76A 2izqA-5mdnA:
undetectable
2izqB-5mdnA:
undetectable		 2izqA-5mdnA:
1.80
2izqB-5mdnA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 TRP A  68
ALA A  16
VAL A  18
 None
 0.72A 2izqA-5nv3A:
undetectable
2izqB-5nv3A:
undetectable		 2izqA-5nv3A:
3.90
2izqB-5nv3A:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC

(Bacillus
subtilis) 		no annotation 3 TRP A  99
ALA A  60
VAL A 218
 None
 0.77A 2izqA-5nxyA:
undetectable
2izqB-5nxyA:
undetectable		 2izqA-5nxyA:
undetectable
2izqB-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC

(Bacillus
subtilis) 		no annotation 3 TRP A 144
ALA A 188
VAL A 140
 None
 0.77A 2izqA-5nxyA:
undetectable
2izqB-5nxyA:
undetectable		 2izqA-5nxyA:
undetectable
2izqB-5nxyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		3 TRP A 401
ALA A 347
VAL A 149
 None
 0.77A 2izqA-5svcA:
undetectable
2izqB-5svcA:
undetectable		 2izqA-5svcA:
3.16
2izqB-5svcA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE

(Leishmania
donovani) 		PF00579
(tRNA-synt_1b) 		3 TRP A 127
ALA A 421
VAL A 130
 None
 0.78A 2izqA-5usfA:
undetectable
2izqB-5usfA:
undetectable		 2izqA-5usfA:
1.88
2izqB-5usfA:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		3 TRP A 766
ALA A 430
VAL A 426
 None
 0.81A 2izqA-5welA:
undetectable
2izqB-5welA:
undetectable		 2izqA-5welA:
1.50
2izqB-5welA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 3 TRP A 475
ALA A 480
VAL A 478
 None
 0.74A 2izqA-5wvbA:
undetectable
2izqB-5wvbA:
undetectable		 2izqA-5wvbA:
undetectable
2izqB-5wvbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xea ENVELOPE
GLYCOPROTEIN

(Thogoto
thogotovirus) 		PF03273
(Baculo_gp64) 		3 TRP A 292
ALA A 297
VAL A 295
 None
 0.70A 2izqA-5xeaA:
undetectable
2izqB-5xeaA:
undetectable		 2izqA-5xeaA:
4.35
2izqB-5xeaA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES19

(Toxoplasma
gondii) 		PF01090
(Ribosomal_S19e) 		3 TRP T  65
ALA T  53
VAL T  50
 None
None
A  21501 ( 4.5A)
 0.82A 2izqA-5xxuT:
undetectable
2izqB-5xxuT:
undetectable		 2izqA-5xxuT:
12.73
2izqB-5xxuT:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y35 -

(-) 		no annotation 3 TRP B 115
ALA B 110
VAL B 112
 None
 0.84A 2izqA-5y35B:
undetectable
2izqB-5y35B:
undetectable		 2izqA-5y35B:
undetectable
2izqB-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 3 TRP A  34
ALA A  99
VAL A  93
 None
 0.83A 2izqA-6ap6A:
undetectable
2izqB-6ap6A:
undetectable		 2izqA-6ap6A:
undetectable
2izqB-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0w HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HISTONE H4

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 TRP A  86
ALA B  83
VAL B  81
 TRP  A  86 ( 0.5A)
ALA  B  83 ( 0.0A)
VAL  B  81 ( 0.6A)
 0.78A 2izqA-6c0wA:
undetectable
2izqB-6c0wA:
undetectable		 2izqA-6c0wA:
undetectable
2izqB-6c0wA:
undetectable