SIMILAR PATTERNS OF AMINO ACIDS FOR 2IZQ_A_DVAA8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 VAL A 236
TRP A 391
VAL A 240
 None
 0.94A 2izqA-1clwA:
undetectable
2izqB-1clwA:
undetectable		 2izqA-1clwA:
2.32
2izqB-1clwA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkf LEUKOCIDIN F SUBUNIT

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 VAL A 166
TRP A 164
VAL A  84
 None
 0.87A 2izqA-1lkfA:
undetectable
2izqB-1lkfA:
undetectable		 2izqA-1lkfA:
4.28
2izqB-1lkfA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		3 VAL A 466
TRP A 313
VAL A 464
 None
 0.63A 2izqA-1m1cA:
undetectable
2izqB-1m1cA:
undetectable		 2izqA-1m1cA:
1.76
2izqB-1m1cA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8u 6-OXO CAMPHOR
HYDROLASE

(Rhodococcus
erythropolis) 		PF00378
(ECH_1) 		3 VAL A 158
TRP A 160
VAL A 163
 None
 0.86A 2izqA-1o8uA:
undetectable
2izqB-1o8uA:
undetectable		 2izqA-1o8uA:
7.48
2izqB-1o8uA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzw TRANSCRIPTION FACTOR
GRAUZONE

(Drosophila
melanogaster) 		PF07776
(zf-AD) 		3 VAL A  55
TRP A  57
VAL A  60
 None
 0.92A 2izqA-1pzwA:
undetectable
2izqB-1pzwA:
undetectable		 2izqA-1pzwA:
18.75
2izqB-1pzwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 VAL G  46
TRP G  44
VAL G  69
 None
 0.70A 2izqA-1rgiG:
undetectable
2izqB-1rgiG:
undetectable		 2izqA-1rgiG:
3.77
2izqB-1rgiG:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1se9 UBIQUITIN FAMILY

(Arabidopsis
thaliana) 		PF13881
(Rad60-SLD_2) 		3 VAL A  53
TRP A  42
VAL A  38
 None
 0.90A 2izqA-1se9A:
undetectable
2izqB-1se9A:
undetectable		 2izqA-1se9A:
16.98
2izqB-1se9A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin)
PF01290
(Thymosin) 		3 VAL G  46
TRP G  44
VAL G  69
 None
 0.73A 2izqA-1t44G:
undetectable
2izqB-1t44G:
undetectable		 2izqA-1t44G:
10.14
2izqB-1t44G:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT

(Pseudomonas
putida) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 VAL A 336
TRP A 338
VAL A 341
 None
 0.94A 2izqA-1wveA:
undetectable
2izqB-1wveA:
undetectable		 2izqA-1wveA:
5.02
2izqB-1wveA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B)
PF02461
(AMO) 		3 VAL A 200
TRP B  87
VAL B  91
 None
 0.68A 2izqA-1yewA:
undetectable
2izqB-1yewA:
undetectable		 2izqA-1yewA:
3.53
2izqB-1yewA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		3 VAL A 278
TRP A 309
VAL A 276
 None
 0.90A 2izqA-1yleA:
undetectable
2izqB-1yleA:
undetectable		 2izqA-1yleA:
4.18
2izqB-1yleA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 VAL A 474
TRP A 557
VAL A 464
 None
 0.82A 2izqA-1yr2A:
undetectable
2izqB-1yr2A:
undetectable		 2izqA-1yr2A:
4.46
2izqB-1yr2A:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 VAL B  38
TRP B 150
VAL B 125
 None
 0.82A 2izqA-2amcB:
undetectable
2izqB-2amcB:
undetectable		 2izqA-2amcB:
2.41
2izqB-2amcB:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cop ACYL-COENZYME A
BINDING DOMAIN
CONTAINING 6

(Homo sapiens) 		PF00887
(ACBP) 		3 VAL A  41
TRP A  65
VAL A  43
 None
 0.79A 2izqA-2copA:
undetectable
2izqB-2copA:
undetectable		 2izqA-2copA:
13.43
2izqB-2copA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		3 VAL A 186
TRP A 200
VAL A 124
 None
 0.91A 2izqA-2depA:
undetectable
2izqB-2depA:
undetectable		 2izqA-2depA:
9.30
2izqB-2depA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK

(Mus musculus) 		PF00017
(SH2) 		3 VAL A  49
TRP A  11
VAL A  36
 None
 0.89A 2izqA-2eu0A:
undetectable
2izqB-2eu0A:
undetectable		 2izqA-2eu0A:
4.59
2izqB-2eu0A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Bacillus
subtilis) 		PF02390
(Methyltransf_4) 		3 VAL A 142
TRP A  31
VAL A 103
 None
 0.88A 2izqA-2fcaA:
undetectable
2izqB-2fcaA:
undetectable		 2izqA-2fcaA:
7.74
2izqB-2fcaA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ff6 GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		3 VAL G  46
TRP G  44
VAL G  69
 None
 0.76A 2izqA-2ff6G:
undetectable
2izqB-2ff6G:
undetectable		 2izqA-2ff6G:
10.11
2izqB-2ff6G:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 VAL A 688
TRP A 659
VAL A 656
 None
 0.96A 2izqA-2g5tA:
undetectable
2izqB-2g5tA:
undetectable		 2izqA-2g5tA:
3.81
2izqB-2g5tA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		3 VAL A  60
TRP A 406
VAL A  64
 None
 0.87A 2izqA-2imrA:
undetectable
2izqB-2imrA:
undetectable		 2izqA-2imrA:
6.03
2izqB-2imrA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l1l EXPORTIN-1

(Homo sapiens) 		no annotation 3 VAL B 602
TRP B 559
VAL B 604
 None
 0.83A 2izqA-2l1lB:
undetectable
2izqB-2l1lB:
undetectable		 2izqA-2l1lB:
12.28
2izqB-2l1lB:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		3 VAL A 224
TRP A 222
VAL A 187
 None
 0.83A 2izqA-2o0xA:
undetectable
2izqB-2o0xA:
undetectable		 2izqA-2o0xA:
3.19
2izqB-2o0xA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 VAL A 689
TRP A 660
VAL A 657
 None
 0.96A 2izqA-2oaeA:
undetectable
2izqB-2oaeA:
undetectable		 2izqA-2oaeA:
2.25
2izqB-2oaeA:
2.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		3 VAL A 656
TRP A 602
VAL A 606
 None
 0.89A 2izqA-2qr7A:
undetectable
2izqB-2qr7A:
undetectable		 2izqA-2qr7A:
4.68
2izqB-2qr7A:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rso CHROMATIN-ASSOCIATED
PROTEIN SWI6

(Schizosaccharomyces
pombe) 		PF00385
(Chromo) 		3 VAL A  86
TRP A 104
VAL A  83
 None
 0.94A 2izqA-2rsoA:
undetectable
2izqB-2rsoA:
undetectable		 2izqA-2rsoA:
10.84
2izqB-2rsoA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		3 VAL A 160
TRP A 172
VAL A  98
 None
 0.85A 2izqA-2uwfA:
undetectable
2izqB-2uwfA:
undetectable		 2izqA-2uwfA:
3.53
2izqB-2uwfA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		3 VAL B 387
TRP B 389
VAL B 392
 None
 0.91A 2izqA-2zbkB:
undetectable
2izqB-2zbkB:
undetectable		 2izqA-2zbkB:
2.39
2izqB-2zbkB:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		3 VAL A 297
TRP A 299
VAL A 302
 None
 0.89A 2izqA-3cerA:
undetectable
2izqB-3cerA:
undetectable		 2izqA-3cerA:
3.21
2izqB-3cerA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		3 VAL A 308
TRP A 295
VAL A 305
 None
 0.90A 2izqA-3e7gA:
undetectable
2izqB-3e7gA:
undetectable		 2izqA-3e7gA:
2.91
2izqB-3e7gA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg4 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Brucella suis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		3 VAL A  49
TRP A  63
VAL A  47
 None
 0.94A 2izqA-3eg4A:
undetectable
2izqB-3eg4A:
undetectable		 2izqA-3eg4A:
3.29
2izqB-3eg4A:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f65 CHAPERONE PROTEIN
FAEE

(Escherichia
coli) 		PF00345
(PapD_N) 		3 VAL A  41
TRP A  84
VAL A  82
 None
 0.73A 2izqA-3f65A:
undetectable
2izqB-3f65A:
undetectable		 2izqA-3f65A:
4.93
2izqB-3f65A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcd RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		3 VAL A  60
TRP A  86
VAL A  36
 None
 0.94A 2izqA-3gcdA:
undetectable
2izqB-3gcdA:
undetectable		 2izqA-3gcdA:
7.93
2izqB-3gcdA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		3 VAL A 164
TRP A 171
VAL A 132
 None
None
SAM  A4633 (-3.6A)
 0.78A 2izqA-3gczA:
undetectable
2izqB-3gczA:
undetectable		 2izqA-3gczA:
6.09
2izqB-3gczA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwq D-SERINE DEAMINASE

(Paraburkholderia
xenovorans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 VAL A  71
TRP A  95
VAL A 273
 None
 0.95A 2izqA-3gwqA:
undetectable
2izqB-3gwqA:
undetectable		 2izqA-3gwqA:
3.82
2izqB-3gwqA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		3 VAL A 234
TRP A  43
VAL A  41
 None
 0.55A 2izqA-3irvA:
undetectable
2izqB-3irvA:
undetectable		 2izqA-3irvA:
9.78
2izqB-3irvA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		3 VAL A 199
TRP A 201
VAL A 204
 None
 0.92A 2izqA-3jxzA:
undetectable
2izqB-3jxzA:
undetectable		 2izqA-3jxzA:
6.67
2izqB-3jxzA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb5 TRIPARTITE
MOTIF-CONTAINING
PROTEIN 72

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 VAL A 335
TRP A 347
VAL A 361
 None
 0.93A 2izqA-3kb5A:
undetectable
2izqB-3kb5A:
undetectable		 2izqA-3kb5A:
7.74
2izqB-3kb5A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkj CD40 LIGAND

(Homo sapiens) 		PF00229
(TNF) 		3 VAL A 237
TRP A 140
VAL A 239
 None
 0.50A 2izqA-3lkjA:
undetectable
2izqB-3lkjA:
undetectable		 2izqA-3lkjA:
4.96
2izqB-3lkjA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lku UPF0363 PROTEIN
YOR164C

(Saccharomyces
cerevisiae) 		PF04190
(DUF410) 		3 VAL A  82
TRP A 122
VAL A  88
 None
 0.85A 2izqA-3lkuA:
undetectable
2izqB-3lkuA:
undetectable		 2izqA-3lkuA:
6.47
2izqB-3lkuA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lub PUTATIVE CREATININE
AMIDOHYDROLASE

(Bacteroides
fragilis) 		PF02633
(Creatininase) 		3 VAL A 213
TRP A 208
VAL A 217
 None
 0.86A 2izqA-3lubA:
undetectable
2izqB-3lubA:
undetectable		 2izqA-3lubA:
4.82
2izqB-3lubA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4e ALPHA-HEMOLYSIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 VAL A 169
TRP A 167
VAL A  86
 None
 0.94A 2izqA-3m4eA:
undetectable
2izqB-3m4eA:
undetectable		 2izqA-3m4eA:
4.10
2izqB-3m4eA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 VAL A  50
TRP A  80
VAL A  52
 None
 0.93A 2izqA-3mgaA:
undetectable
2izqB-3mgaA:
undetectable		 2izqA-3mgaA:
3.23
2izqB-3mgaA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 VAL A 251
TRP A 253
VAL A 256
 None
 0.80A 2izqA-3mjfA:
undetectable
2izqB-3mjfA:
undetectable		 2izqA-3mjfA:
3.80
2izqB-3mjfA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 3 VAL A 352
TRP A 143
VAL A 342
 None
 0.76A 2izqA-3nlcA:
undetectable
2izqB-3nlcA:
undetectable		 2izqA-3nlcA:
2.41
2izqB-3nlcA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		3 VAL A 125
TRP A 123
VAL A 120
 None
 0.92A 2izqA-3pvtA:
undetectable
2izqB-3pvtA:
undetectable		 2izqA-3pvtA:
7.10
2izqB-3pvtA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rom ADP-RIBOSYL CYCLASE
1

(Homo sapiens) 		PF02267
(Rib_hydrolayse) 		3 VAL A 187
TRP A 189
VAL A 192
 None
 0.95A 2izqA-3romA:
undetectable
2izqB-3romA:
undetectable		 2izqA-3romA:
6.11
2izqB-3romA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 VAL A 349
TRP A  28
VAL A 351
 None
 0.68A 2izqA-3t8qA:
undetectable
2izqB-3t8qA:
undetectable		 2izqA-3t8qA:
8.14
2izqB-3t8qA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfz CYCLASE

(Streptomyces
sp. R1128) 		PF10604
(Polyketide_cyc2) 		3 VAL A  37
TRP A  62
VAL A  53
 None
CXS  A 171 (-4.4A)
None
 0.85A 2izqA-3tfzA:
undetectable
2izqB-3tfzA:
undetectable		 2izqA-3tfzA:
11.00
2izqB-3tfzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu5 GELSOLIN,PROTEIN
CORDON-BLEU,THYMOSIN
BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin) 		3 VAL B  22
TRP B  20
VAL B  45
 None
 0.76A 2izqA-3tu5B:
undetectable
2izqB-3tu5B:
undetectable		 2izqA-3tu5B:
4.65
2izqB-3tu5B:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2a GGDEF FAMILY PROTEIN

(Caulobacter
vibrioides) 		no annotation 3 VAL A  86
TRP A  99
VAL A  75
 None
 0.93A 2izqA-3u2aA:
undetectable
2izqB-3u2aA:
undetectable		 2izqA-3u2aA:
11.32
2izqB-3u2aA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 VAL B 588
TRP B 591
VAL B 745
 None
 0.95A 2izqA-3v0aB:
undetectable
2izqB-3v0aB:
undetectable		 2izqA-3v0aB:
1.19
2izqB-3v0aB:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 VAL A1883
TRP A1823
VAL A1888
 None
 0.94A 2izqA-3vkgA:
undetectable
2izqB-3vkgA:
undetectable		 2izqA-3vkgA:
1.24
2izqB-3vkgA:
1.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		3 VAL A 164
TRP A  64
VAL A 166
 ADE  A 301 (-3.8A)
None
None
 0.79A 2izqA-3wazA:
undetectable
2izqB-3wazA:
undetectable		 2izqA-3wazA:
5.35
2izqB-3wazA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 VAL A 116
TRP A 129
VAL A 151
 None
 0.95A 2izqA-3wfzA:
undetectable
2izqB-3wfzA:
undetectable		 2izqA-3wfzA:
1.68
2izqB-3wfzA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		3 VAL A 685
TRP A 659
VAL A 690
 None
 0.89A 2izqA-4av6A:
undetectable
2izqB-4av6A:
undetectable		 2izqA-4av6A:
3.69
2izqB-4av6A:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D

(Phanerochaete
chrysosporium) 		PF03443
(Glyco_hydro_61) 		3 VAL A  19
TRP A  18
VAL A  21
 None
 0.90A 2izqA-4b5qA:
undetectable
2izqB-4b5qA:
undetectable		 2izqA-4b5qA:
5.26
2izqB-4b5qA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		3 VAL A 606
TRP A 585
VAL A 601
 None
 0.84A 2izqA-4bq4A:
undetectable
2izqB-4bq4A:
undetectable		 2izqA-4bq4A:
3.61
2izqB-4bq4A:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		3 VAL A  96
TRP A 105
VAL A  20
 None
 0.92A 2izqA-4d7pA:
undetectable
2izqB-4d7pA:
undetectable		 2izqA-4d7pA:
8.05
2izqB-4d7pA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		3 VAL A 361
TRP A 334
VAL A 339
 None
 0.89A 2izqA-4ftdA:
undetectable
2izqB-4ftdA:
undetectable		 2izqA-4ftdA:
2.43
2izqB-4ftdA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14

(Homo sapiens) 		PF00229
(TNF) 		3 VAL A 215
TRP A 114
VAL A 217
 None
 0.72A 2izqA-4kg8A:
undetectable
2izqB-4kg8A:
undetectable		 2izqA-4kg8A:
11.21
2izqB-4kg8A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf9 HEMIN DEGRADING
FACTOR

(Pseudomonas
aeruginosa) 		PF05171
(HemS) 		3 VAL A 314
TRP A 202
VAL A 305
 HEM  A 400 ( 4.9A)
None
None
 0.56A 2izqA-4mf9A:
undetectable
2izqB-4mf9A:
undetectable		 2izqA-4mf9A:
4.30
2izqB-4mf9A:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A  36
TRP A  34
VAL A  30
 None
 0.72A 2izqA-4nfnA:
undetectable
2izqB-4nfnA:
undetectable		 2izqA-4nfnA:
4.45
2izqB-4nfnA:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51

(Mus musculus) 		PF03281
(Mab-21) 		3 VAL A 252
TRP A 337
VAL A 262
 None
 0.85A 2izqA-4oahA:
undetectable
2izqB-4oahA:
undetectable		 2izqA-4oahA:
3.75
2izqB-4oahA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT

(Cupriavidus
necator) 		PF03480
(DctP) 		3 VAL A 144
TRP A 253
VAL A 248
 None
 0.93A 2izqA-4p8bA:
undetectable
2izqB-4p8bA:
undetectable		 2izqA-4p8bA:
8.12
2izqB-4p8bA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkh GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin)
PF03250
(Tropomodulin) 		3 VAL B  73
TRP B  71
VAL B  96
 None
 0.69A 2izqA-4pkhB:
undetectable
2izqB-4pkhB:
undetectable		 2izqA-4pkhB:
4.42
2izqB-4pkhB:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		3 VAL G  73
TRP G  71
VAL G  96
 None
 0.74A 2izqA-4pkiG:
undetectable
2izqB-4pkiG:
undetectable		 2izqA-4pkiG:
8.47
2izqB-4pkiG:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		3 VAL A 160
TRP A 172
VAL A  98
 None
 0.91A 2izqA-4pueA:
undetectable
2izqB-4pueA:
undetectable		 2izqA-4pueA:
3.28
2izqB-4pueA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7g LEUCOTOXIN LUKDV

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 VAL A 192
TRP A 190
VAL A 110
 None
 0.88A 2izqA-4q7gA:
undetectable
2izqB-4q7gA:
undetectable		 2izqA-4q7gA:
5.09
2izqB-4q7gA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY

(Bordetella
pertussis) 		PF11563
(Protoglobin) 		3 VAL A  89
TRP A  72
VAL A  76
 None
HEM  A 200 (-3.2A)
None
 0.81A 2izqA-4uiqA:
undetectable
2izqB-4uiqA:
undetectable		 2izqA-4uiqA:
15.69
2izqB-4uiqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		3 VAL A 105
TRP A  96
VAL A 269
 None
 0.90A 2izqA-4v1uA:
undetectable
2izqB-4v1uA:
undetectable		 2izqA-4v1uA:
2.94
2izqB-4v1uA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk0 INTEGRIN BETA-1

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		3 VAL B 240
TRP B 247
VAL B 238
 None
 0.94A 2izqA-4wk0B:
undetectable
2izqB-4wk0B:
undetectable		 2izqA-4wk0B:
3.23
2izqB-4wk0B:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		3 VAL A  88
TRP A  90
VAL A  93
 None
78M  A 510 ( 4.2A)
None
 0.95A 2izqA-4xniA:
undetectable
2izqB-4xniA:
undetectable		 2izqA-4xniA:
6.55
2izqB-4xniA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A 230
TRP A 208
VAL A 232
 None
NAP  A 501 ( 4.8A)
None
 0.96A 2izqA-4y1bA:
undetectable
2izqB-4y1bA:
undetectable		 2izqA-4y1bA:
4.78
2izqB-4y1bA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		3 VAL C 335
TRP C 550
VAL C 340
 None
 0.86A 2izqA-4yfaC:
undetectable
2izqB-4yfaC:
undetectable		 2izqA-4yfaC:
3.66
2izqB-4yfaC:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		3 VAL A 537
TRP A 752
VAL A 542
 None
 0.92A 2izqA-5c9iA:
undetectable
2izqB-5c9iA:
undetectable		 2izqA-5c9iA:
2.18
2izqB-5c9iA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9l PLL LECTIN

(Photorhabdus
luminescens) 		PF03984
(DUF346) 		3 VAL A  72
TRP A 114
VAL A  49
 None
 0.95A 2izqA-5c9lA:
undetectable
2izqB-5c9lA:
undetectable		 2izqA-5c9lA:
4.52
2izqB-5c9lA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cze PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		3 VAL B  79
TRP B   6
VAL B  81
 None
 0.90A 2izqA-5czeB:
undetectable
2izqB-5czeB:
undetectable		 2izqA-5czeB:
17.95
2izqB-5czeB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czf PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		3 VAL C  79
TRP C   6
VAL C  81
 None
 0.94A 2izqA-5czfC:
undetectable
2izqB-5czfC:
undetectable		 2izqA-5czfC:
14.29
2izqB-5czfC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H)
PF00078
(RVT_1) 		3 VAL A 546
TRP A 521
VAL A 540
 None
 0.88A 2izqA-5dmqA:
undetectable
2izqB-5dmqA:
undetectable		 2izqA-5dmqA:
9.09
2izqB-5dmqA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmu NHEJ POLYMERASE

(Methanocella
paludicola) 		no annotation 3 VAL A 196
TRP A 272
VAL A 194
 None
 0.84A 2izqA-5dmuA:
undetectable
2izqB-5dmuA:
undetectable		 2izqA-5dmuA:
4.63
2izqB-5dmuA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		3 VAL A 164
TRP A 171
VAL A 132
 None
None
SAM  A 301 (-3.6A)
 0.87A 2izqA-5e9qA:
undetectable
2izqB-5e9qA:
undetectable		 2izqA-5e9qA:
4.84
2izqB-5e9qA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		3 VAL A 133
TRP A  16
VAL A  39
 None
 0.76A 2izqA-5gqtA:
undetectable
2izqB-5gqtA:
undetectable		 2izqA-5gqtA:
2.86
2izqB-5gqtA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h83 HETEROYOHIMBINE
SYNTHASE HYS

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  78
TRP A 149
VAL A  76
 None
 0.92A 2izqA-5h83A:
undetectable
2izqB-5h83A:
undetectable		 2izqA-5h83A:
6.02
2izqB-5h83A:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijv BOVINE FAB E03 HEAVY
CHAIN

(Bos taurus) 		no annotation 3 VAL H  34
TRP H 134
VAL H 136
 None
 0.96A 2izqA-5ijvH:
undetectable
2izqB-5ijvH:
undetectable		 2izqA-5ijvH:
5.39
2izqB-5ijvH:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H  34
TRP H 151
VAL H 153
 None
 0.88A 2izqA-5iltH:
undetectable
2izqB-5iltH:
undetectable		 2izqA-5iltH:
6.45
2izqB-5iltH:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 VAL A 164
TRP A 171
VAL A 132
 None
None
SAH  A1003 (-3.7A)
 0.84A 2izqA-5jjrA:
undetectable
2izqB-5jjrA:
undetectable		 2izqA-5jjrA:
2.83
2izqB-5jjrA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1

(Staphylococcus
aureus) 		no annotation 3 VAL B 170
TRP B 168
VAL B  86
 None
 0.93A 2izqA-5k59B:
undetectable
2izqB-5k59B:
undetectable		 2izqA-5k59B:
8.59
2izqB-5k59B:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 3 VAL D 193
TRP D 191
VAL D 113
 None
 0.72A 2izqA-5k59D:
undetectable
2izqB-5k59D:
undetectable		 2izqA-5k59D:
4.52
2izqB-5k59D:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 VAL A 150
TRP A 152
VAL A 133
 None
 0.82A 2izqA-5mdnA:
undetectable
2izqB-5mdnA:
undetectable		 2izqA-5mdnA:
1.80
2izqB-5mdnA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n07 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR NSRR

(Streptomyces
coelicolor) 		PF02082
(Rrf2) 		3 VAL A  77
TRP A  79
VAL A  75
 None
 0.80A 2izqA-5n07A:
undetectable
2izqB-5n07A:
undetectable		 2izqA-5n07A:
8.73
2izqB-5n07A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN
CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1;
Rosellinia
necatrix
quadrivirus 1) 		no annotation
no annotation 		3 VAL A 893
TRP B 906
VAL B 904
 None
 0.83A 2izqA-5nd1A:
undetectable
2izqB-5nd1A:
undetectable		 2izqA-5nd1A:
undetectable
2izqB-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		3 VAL A 437
TRP A 346
VAL A 435
 None
 0.90A 2izqA-5nd4A:
undetectable
2izqB-5nd4A:
undetectable		 2izqA-5nd4A:
3.21
2izqB-5nd4A:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o64 REACTION CENTER
PROTEIN H CHAIN

(Blastochloris
viridis) 		PF03967
(PRCH)
PF05239
(PRC) 		3 VAL H  23
TRP H  25
VAL H  28
 None
 0.82A 2izqA-5o64H:
undetectable
2izqB-5o64H:
undetectable		 2izqA-5o64H:
6.40
2izqB-5o64H:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 VAL A1101
TRP A1153
VAL A1151
 None
 0.80A 2izqA-5vadA:
undetectable
2izqB-5vadA:
undetectable		 2izqA-5vadA:
4.32
2izqB-5vadA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnm PHOTOSYSTEM II
REACTION CENTER
PROTEIN Z

(Pisum sativum) 		PF01737
(Ycf9) 		3 VAL Z   9
TRP Z  47
VAL Z  51
 None
 0.79A 2izqA-5xnmZ:
undetectable
2izqB-5xnmZ:
undetectable		 2izqA-5xnmZ:
20.37
2izqB-5xnmZ:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 3 VAL A 406
TRP A 408
VAL A 396
 None
 0.92A 2izqA-6cmzA:
undetectable
2izqB-6cmzA:
undetectable		 2izqA-6cmzA:
undetectable
2izqB-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 3 VAL B  61
TRP B  48
VAL B  63
 None
 0.84A 2izqA-6cxhB:
undetectable
2izqB-6cxhB:
undetectable		 2izqA-6cxhB:
undetectable
2izqB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 3 VAL A 155
TRP A 167
VAL A  93
 None
 0.88A 2izqA-6fheA:
undetectable
2izqB-6fheA:
undetectable		 2izqA-6fheA:
undetectable
2izqB-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 3 VAL A 160
TRP A 174
VAL A  98
 None
 0.88A 2izqA-6fhfA:
undetectable
2izqB-6fhfA:
undetectable		 2izqA-6fhfA:
undetectable
2izqB-6fhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 3 VAL A 665
TRP A 702
VAL A 706
 None
 0.79A 2izqA-6fuyA:
undetectable
2izqB-6fuyA:
undetectable		 2izqA-6fuyA:
undetectable
2izqB-6fuyA:
undetectable