SIMILAR PATTERNS OF AMINO ACIDS FOR 2IZQ_A_DVAA6_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		3 ALA A  55
VAL A  99
TRP A 215
 None
0GJ  A   1 ( 4.2A)
None
 0.76A 2izqA-1bqyA:
undetectable
2izqB-1bqyA:
undetectable		 2izqA-1bqyA:
7.01
2izqB-1bqyA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byr PROTEIN
(ENDONUCLEASE)

(Salmonella
enterica) 		PF13091
(PLDc_2) 		3 ALA A  34
VAL A  59
TRP A 141
 None
 0.99A 2izqA-1byrA:
undetectable
2izqB-1byrA:
undetectable		 2izqA-1byrA:
7.75
2izqB-1byrA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ALA A 238
VAL A 224
TRP A 240
 None
 0.77A 2izqA-1d6mA:
undetectable
2izqB-1d6mA:
undetectable		 2izqA-1d6mA:
3.41
2izqB-1d6mA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ALA A 416
VAL A 414
TRP A 403
 None
 0.97A 2izqA-1ethA:
undetectable
2izqB-1ethA:
undetectable		 2izqA-1ethA:
3.41
2izqB-1ethA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkt HEAT-SHOCK
TRANSCRIPTION FACTOR

(Drosophila
melanogaster) 		PF00447
(HSF_DNA-bind) 		3 ALA A  60
VAL A  57
TRP A  68
 None
 0.87A 2izqA-1hktA:
undetectable
2izqB-1hktA:
undetectable		 2izqA-1hktA:
17.02
2izqB-1hktA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13561
(adh_short_C2) 		3 ALA A 137
VAL A 139
TRP A 142
 None
 0.99A 2izqA-1hxhA:
undetectable
2izqB-1hxhA:
undetectable		 2izqA-1hxhA:
7.25
2izqB-1hxhA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		3 ALA A  48
VAL A  53
TRP A 246
 None
 0.86A 2izqA-1hzvA:
undetectable
2izqB-1hzvA:
undetectable		 2izqA-1hzvA:
4.44
2izqB-1hzvA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 ALA A 797
VAL A 799
TRP A 679
 None
 1.00A 2izqA-1ileA:
undetectable
2izqB-1ileA:
undetectable		 2izqA-1ileA:
1.97
2izqB-1ileA:
1.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		3 ALA A  53
VAL A  50
TRP A  44
 None
 0.81A 2izqA-1j5sA:
undetectable
2izqB-1j5sA:
undetectable		 2izqA-1j5sA:
5.24
2izqB-1j5sA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		3 ALA A 335
VAL A 338
TRP A 378
 None
 0.85A 2izqA-1kfwA:
undetectable
2izqB-1kfwA:
undetectable		 2izqA-1kfwA:
3.19
2izqB-1kfwA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ALA B 417
VAL B 415
TRP B 402
 None
 0.94A 2izqA-1lpbB:
undetectable
2izqB-1lpbB:
undetectable		 2izqA-1lpbB:
3.70
2izqB-1lpbB:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 ALA A 184
VAL A 174
TRP A  81
 None
None
PIM  A1408 (-4.6A)
 0.65A 2izqA-1odoA:
undetectable
2izqB-1odoA:
undetectable		 2izqA-1odoA:
14.86
2izqB-1odoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ALA A  41
VAL A  57
TRP A  95
 None
 0.93A 2izqA-1pguA:
undetectable
2izqB-1pguA:
undetectable		 2izqA-1pguA:
2.83
2izqB-1pguA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhq PROTEIN (AURACYANIN)

(Chloroflexus
aurantiacus) 		PF00127
(Copper-bind) 		3 ALA A  23
VAL A  21
TRP A  59
 None
 0.87A 2izqA-1qhqA:
undetectable
2izqB-1qhqA:
undetectable		 2izqA-1qhqA:
6.43
2izqB-1qhqA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT

(Pseudomonas
putida) 		PF00676
(E1_dh)
PF12573
(OxoDH_E1alpha_N) 		3 ALA A  32
VAL A  55
TRP A  68
 None
 0.90A 2izqA-1qs0A:
undetectable
2izqB-1qs0A:
undetectable		 2izqA-1qs0A:
9.65
2izqB-1qs0A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		3 ALA A 274
VAL A 255
TRP A 256
 None
 0.96A 2izqA-1to3A:
undetectable
2izqB-1to3A:
undetectable		 2izqA-1to3A:
6.40
2izqB-1to3A:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		3 ALA A 174
VAL A 369
TRP A 365
 None
 0.90A 2izqA-1u7gA:
undetectable
2izqB-1u7gA:
undetectable		 2izqA-1u7gA:
5.19
2izqB-1u7gA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		3 ALA A 137
VAL A 139
TRP A 186
 None
 0.83A 2izqA-1up2A:
undetectable
2izqB-1up2A:
undetectable		 2izqA-1up2A:
6.25
2izqB-1up2A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		3 ALA A 235
VAL A 232
TRP A 205
 None
 0.99A 2izqA-1wraA:
undetectable
2izqB-1wraA:
undetectable		 2izqA-1wraA:
3.85
2izqB-1wraA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN

(Aspergillus
niger) 		PF01828
(Peptidase_A4) 		3 ALA B   9
VAL B  11
TRP B 107
 None
 0.59A 2izqA-1y43B:
undetectable
2izqB-1y43B:
undetectable		 2izqA-1y43B:
6.13
2izqB-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2i MALATE DEHYDROGENASE

(Agrobacterium
tumefaciens) 		PF02615
(Ldh_2) 		3 ALA A 174
VAL A 172
TRP A 180
 None
 1.00A 2izqA-1z2iA:
undetectable
2izqB-1z2iA:
undetectable		 2izqA-1z2iA:
4.05
2izqB-1z2iA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE

(Chromobacterium
violaceum) 		PF01503
(PRA-PH) 		3 ALA A  45
VAL A  64
TRP A  68
 None
 0.75A 2izqA-2a7wA:
undetectable
2izqB-2a7wA:
undetectable		 2izqA-2a7wA:
8.04
2izqB-2a7wA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		3 ALA A 210
VAL A 207
TRP A 180
 None
 0.95A 2izqA-2bibA:
undetectable
2izqB-2bibA:
undetectable		 2izqA-2bibA:
2.24
2izqB-2bibA:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE

(Escherichia
coli) 		PF02734
(Dak2) 		3 ALA A 123
VAL A 117
TRP A 134
 ADP  A1211 ( 4.4A)
None
None
 0.91A 2izqA-2btdA:
undetectable
2izqB-2btdA:
undetectable		 2izqA-2btdA:
7.52
2izqB-2btdA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3y URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		3 ALA A 116
VAL A  43
TRP A  39
 None
 0.78A 2izqA-2d3yA:
undetectable
2izqB-2d3yA:
undetectable		 2izqA-2d3yA:
8.73
2izqB-2d3yA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A  85
VAL A 101
TRP A 102
 None
None
MPD  A   1 ( 3.9A)
 0.93A 2izqA-2d4wA:
undetectable
2izqB-2d4wA:
undetectable		 2izqA-2d4wA:
4.98
2izqB-2d4wA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ed7 NETRIN RECEPTOR DCC

(Homo sapiens) 		PF00041
(fn3) 		3 ALA A  44
VAL A  16
TRP A  97
 None
 0.97A 2izqA-2ed7A:
undetectable
2izqB-2ed7A:
undetectable		 2izqA-2ed7A:
10.20
2izqB-2ed7A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		3 ALA A  89
VAL A 151
TRP A 103
 None
 0.99A 2izqA-2nwqA:
undetectable
2izqB-2nwqA:
undetectable		 2izqA-2nwqA:
3.98
2izqB-2nwqA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM

(Bacillus
subtilis) 		PF13472
(Lipase_GDSL_2) 		3 ALA A 185
VAL A 173
TRP A 187
 None
 0.98A 2izqA-2o14A:
undetectable
2izqB-2o14A:
undetectable		 2izqA-2o14A:
4.14
2izqB-2o14A:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		3 ALA A 287
VAL A 289
TRP A 243
 None
 0.94A 2izqA-2vx4A:
undetectable
2izqB-2vx4A:
undetectable		 2izqA-2vx4A:
2.86
2izqB-2vx4A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		3 ALA A 111
VAL A 113
TRP A 109
 None
 1.00A 2izqA-2wk8A:
undetectable
2izqB-2wk8A:
undetectable		 2izqA-2wk8A:
5.56
2izqB-2wk8A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ydy METHIONINE
ADENOSYLTRANSFERASE
2 SUBUNIT BETA

(Homo sapiens) 		PF04321
(RmlD_sub_bind) 		3 ALA A 228
VAL A 230
TRP A 250
 None
 0.97A 2izqA-2ydyA:
undetectable
2izqB-2ydyA:
undetectable		 2izqA-2ydyA:
5.91
2izqB-2ydyA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		3 ALA A 271
VAL A 298
TRP A 323
 None
 0.77A 2izqA-3axxA:
undetectable
2izqB-3axxA:
undetectable		 2izqA-3axxA:
3.23
2izqB-3axxA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fld PROTEIN TRAI

(Escherichia
coli) 		PF07057
(TraI) 		3 ALA A1569
VAL A1572
TRP A1542
 None
 0.99A 2izqA-3fldA:
undetectable
2izqB-3fldA:
undetectable		 2izqA-3fldA:
6.67
2izqB-3fldA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnu 25 KDA PROTEIN
ELICITOR

(Pythium
aphanidermatum) 		PF05630
(NPP1) 		3 ALA P  69
VAL P  71
TRP P  88
 None
 0.98A 2izqA-3gnuP:
undetectable
2izqB-3gnuP:
undetectable		 2izqA-3gnuP:
6.82
2izqB-3gnuP:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtz PUTATIVE TRANSLATION
INITIATION INHIBITOR

(Salmonella
enterica) 		PF01042
(Ribonuc_L-PSP) 		3 ALA A  82
VAL A  84
TRP A  80
 None
 0.93A 2izqA-3gtzA:
undetectable
2izqB-3gtzA:
undetectable		 2izqA-3gtzA:
28.57
2izqB-3gtzA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 ALA A 880
VAL A 878
TRP A 441
 None
 0.99A 2izqA-3ikmA:
undetectable
2izqB-3ikmA:
undetectable		 2izqA-3ikmA:
1.98
2izqB-3ikmA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njb ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		3 ALA A 281
VAL A 283
TRP A 177
 None
 0.77A 2izqA-3njbA:
undetectable
2izqB-3njbA:
undetectable		 2izqA-3njbA:
6.80
2izqB-3njbA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		3 ALA A 342
VAL A 340
TRP A  61
 None
None
HEM  A 417 (-4.1A)
 0.42A 2izqA-3oftA:
undetectable
2izqB-3oftA:
undetectable		 2izqA-3oftA:
19.64
2izqB-3oftA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN

(Escherichia
coli) 		PF00374
(NiFeSe_Hases) 		3 ALA L 517
VAL L 502
TRP L 515
 None
 0.85A 2izqA-3uscL:
undetectable
2izqB-3uscL:
undetectable		 2izqA-3uscL:
5.26
2izqB-3uscL:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		3 ALA A 418
VAL A 363
TRP A 365
 None
 0.73A 2izqA-3ut2A:
undetectable
2izqB-3ut2A:
undetectable		 2izqA-3ut2A:
3.08
2izqB-3ut2A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE

(Caulobacter
vibrioides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A 266
VAL A 268
TRP A 269
 None
 0.91A 2izqA-3vcnA:
undetectable
2izqB-3vcnA:
undetectable		 2izqA-3vcnA:
5.02
2izqB-3vcnA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		3 ALA A 271
VAL A 298
TRP A 323
 None
 0.78A 2izqA-3w6mA:
undetectable
2izqB-3w6mA:
undetectable		 2izqA-3w6mA:
3.53
2izqB-3w6mA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcc PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		3 ALA A 196
VAL A  16
TRP A 200
 None
 0.88A 2izqA-4dccA:
undetectable
2izqB-4dccA:
undetectable		 2izqA-4dccA:
5.63
2izqB-4dccA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		3 ALA A  49
VAL A  98
TRP A 192
 None
 0.85A 2izqA-4di1A:
undetectable
2izqB-4di1A:
undetectable		 2izqA-4di1A:
17.39
2izqB-4di1A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ALA A 468
VAL A 470
TRP A 513
 None
 0.95A 2izqA-4epaA:
undetectable
2izqB-4epaA:
undetectable		 2izqA-4epaA:
2.15
2izqB-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2

(Pleurotus
eryngii) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 ALA A 167
VAL A 163
TRP A 164
 None
 0.96A 2izqA-4fcsA:
undetectable
2izqB-4fcsA:
undetectable		 2izqA-4fcsA:
6.25
2izqB-4fcsA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		3 ALA A  68
VAL A 168
TRP A  70
 None
NAG  A 415 ( 4.6A)
NAG  A 415 ( 4.1A)
 0.99A 2izqA-4fomA:
undetectable
2izqB-4fomA:
undetectable		 2izqA-4fomA:
4.86
2izqB-4fomA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		3 ALA A 362
VAL A 323
TRP A 334
 None
 0.96A 2izqA-4ftdA:
undetectable
2izqB-4ftdA:
undetectable		 2izqA-4ftdA:
2.43
2izqB-4ftdA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi4 AEROTAXIS TRANSDUCER
AER2

(Pseudomonas
aeruginosa) 		PF13188
(PAS_8) 		3 ALA A 184
VAL A 202
TRP A 283
 None
 0.68A 2izqA-4hi4A:
undetectable
2izqB-4hi4A:
undetectable		 2izqA-4hi4A:
8.74
2izqB-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		3 ALA A 242
VAL A 244
TRP A 237
 None
 0.96A 2izqA-4i59A:
undetectable
2izqB-4i59A:
undetectable		 2izqA-4i59A:
5.66
2izqB-4i59A:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F

(Homo sapiens) 		PF08210
(APOBEC_N) 		3 ALA A 250
VAL A 242
TRP A 277
 None
 0.89A 2izqA-4j4jA:
undetectable
2izqB-4j4jA:
undetectable		 2izqA-4j4jA:
5.67
2izqB-4j4jA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		3 ALA A 298
VAL A 301
TRP A 285
 None
 0.99A 2izqA-4mptA:
undetectable
2izqB-4mptA:
undetectable		 2izqA-4mptA:
5.63
2izqB-4mptA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 ALA A 277
VAL A 326
TRP A 310
 None
None
P5F  A1101 (-3.6A)
 0.85A 2izqA-4nmeA:
undetectable
2izqB-4nmeA:
undetectable		 2izqA-4nmeA:
2.23
2izqB-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8a BIFUNCTIONAL PROTEIN
PUTA

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 ALA A 405
VAL A 455
TRP A 438
 None
None
FAD  A2001 (-3.5A)
 0.98A 2izqA-4o8aA:
undetectable
2izqB-4o8aA:
undetectable		 2izqA-4o8aA:
3.02
2izqB-4o8aA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		3 ALA A 288
VAL A 290
TRP A  34
 None
 0.87A 2izqA-4pviA:
undetectable
2izqB-4pviA:
undetectable		 2izqA-4pviA:
3.27
2izqB-4pviA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 ALA A 313
VAL A 363
TRP A 346
 None
None
FAD  A2001 (-3.6A)
 0.96A 2izqA-4q73A:
undetectable
2izqB-4q73A:
undetectable		 2izqA-4q73A:
2.58
2izqB-4q73A:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		3 ALA A  75
VAL A  92
TRP A 143
 None
 0.95A 2izqA-4qt9A:
undetectable
2izqB-4qt9A:
undetectable		 2izqA-4qt9A:
3.38
2izqB-4qt9A:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		3 ALA A 566
VAL A 213
TRP A 291
 None
 0.86A 2izqA-4r12A:
undetectable
2izqB-4r12A:
undetectable		 2izqA-4r12A:
2.43
2izqB-4r12A:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 3 ALA A 190
VAL A 172
TRP A 170
 None
 0.91A 2izqA-4tz5A:
undetectable
2izqB-4tz5A:
undetectable		 2izqA-4tz5A:
3.34
2izqB-4tz5A:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		3 ALA A 238
VAL A 174
TRP A 240
 None
 0.97A 2izqA-4wt7A:
undetectable
2izqB-4wt7A:
undetectable		 2izqA-4wt7A:
5.50
2izqB-4wt7A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 ALA A 203
VAL A 207
TRP A 119
 None
 0.93A 2izqA-4ymkA:
undetectable
2izqB-4ymkA:
undetectable		 2izqA-4ymkA:
8.89
2izqB-4ymkA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 3 ALA A 207
VAL A 211
TRP A 123
 None
 0.92A 2izqA-4zyoA:
undetectable
2izqB-4zyoA:
undetectable		 2izqA-4zyoA:
4.47
2izqB-4zyoA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ALA A 578
VAL A 529
TRP A 501
 None
 0.49A 2izqA-5a7mA:
undetectable
2izqB-5a7mA:
undetectable		 2izqA-5a7mA:
1.95
2izqB-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ALA A 166
VAL A 213
TRP A 229
 None
 0.70A 2izqA-5a8rA:
undetectable
2izqB-5a8rA:
undetectable		 2izqA-5a8rA:
4.08
2izqB-5a8rA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		3 ALA J 121
VAL J  95
TRP J 387
 None
 0.92A 2izqA-5afuJ:
undetectable
2izqB-5afuJ:
undetectable		 2izqA-5afuJ:
2.93
2izqB-5afuJ:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aid MEP2

(Candida
albicans) 		PF00909
(Ammonium_transp) 		3 ALA A 194
VAL A 398
TRP A 394
 None
 0.87A 2izqA-5aidA:
undetectable
2izqB-5aidA:
undetectable		 2izqA-5aidA:
7.37
2izqB-5aidA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		3 ALA A 355
VAL A 391
TRP A 368
 None
 0.85A 2izqA-5cjuA:
undetectable
2izqB-5cjuA:
undetectable		 2izqA-5cjuA:
2.13
2izqB-5cjuA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 ALA A 483
VAL A 485
TRP A 548
 None
 0.94A 2izqA-5clwA:
undetectable
2izqB-5clwA:
undetectable		 2izqA-5clwA:
2.52
2izqB-5clwA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dji 3'-PHOSPHOADENOSINE
5'-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		3 ALA A 112
VAL A  87
TRP A 114
 None
 0.95A 2izqA-5djiA:
undetectable
2izqB-5djiA:
undetectable		 2izqA-5djiA:
4.17
2izqB-5djiA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		3 ALA A 481
VAL A 342
TRP A 213
 CZE  A 613 ( 4.6A)
None
None
 0.97A 2izqA-5dqfA:
undetectable
2izqB-5dqfA:
undetectable		 2izqA-5dqfA:
2.29
2izqB-5dqfA:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewn STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF03115
(Astro_capsid_N) 		3 ALA A 376
VAL A 369
TRP A 351
 None
 0.90A 2izqA-5ewnA:
undetectable
2izqB-5ewnA:
undetectable		 2izqA-5ewnA:
6.37
2izqB-5ewnA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ALA A 319
VAL A 301
TRP A 314
 None
 0.96A 2izqA-5favA:
undetectable
2izqB-5favA:
undetectable		 2izqA-5favA:
1.58
2izqB-5favA:
1.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		3 ALA H 117
VAL H 119
TRP H 124
 None
 0.78A 2izqA-5g06H:
undetectable
2izqB-5g06H:
undetectable		 2izqA-5g06H:
4.71
2izqB-5g06H:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A 473
VAL A 471
TRP A 465
 None
 0.94A 2izqA-5gn5A:
undetectable
2izqB-5gn5A:
undetectable		 2izqA-5gn5A:
2.16
2izqB-5gn5A:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		3 ALA A  52
VAL A  69
TRP A 120
 None
IOD  A 506 ( 4.7A)
None
 0.97A 2izqA-5gzhA:
undetectable
2izqB-5gzhA:
undetectable		 2izqA-5gzhA:
3.11
2izqB-5gzhA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		3 ALA A 305
VAL A 303
TRP A 288
 None
 0.97A 2izqA-5hy5A:
undetectable
2izqB-5hy5A:
undetectable		 2izqA-5hy5A:
3.14
2izqB-5hy5A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		3 ALA B 478
VAL B 472
TRP B 473
 None
 0.77A 2izqA-5kohB:
undetectable
2izqB-5kohB:
undetectable		 2izqA-5kohB:
3.10
2izqB-5kohB:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6m RIBONUCLEASE VAPC

(Caulobacter
vibrioides) 		PF01850
(PIN) 		3 ALA B 114
VAL B 110
TRP B 128
 None
 0.88A 2izqA-5l6mB:
undetectable
2izqB-5l6mB:
undetectable		 2izqA-5l6mB:
8.00
2izqB-5l6mB:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnl HSF

(Haemophilus
influenzae) 		PF15401
(TAA-Trp-ring) 		3 ALA A1689
VAL A1708
TRP A1691
 None
 0.69A 2izqA-5lnlA:
undetectable
2izqB-5lnlA:
undetectable		 2izqA-5lnlA:
11.84
2izqB-5lnlA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpe KALLIKREIN-10

(Homo sapiens) 		PF00089
(Trypsin) 		3 ALA A  43
VAL A  45
TRP A  29
 None
 1.00A 2izqA-5lpeA:
undetectable
2izqB-5lpeA:
undetectable		 2izqA-5lpeA:
11.25
2izqB-5lpeA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		3 ALA A 301
VAL A 299
TRP A 284
 None
 0.92A 2izqA-5lv9A:
undetectable
2izqB-5lv9A:
undetectable		 2izqA-5lv9A:
4.63
2izqB-5lv9A:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		3 ALA A 275
VAL A 337
TRP A 391
 None
 0.98A 2izqA-5mulA:
undetectable
2izqB-5mulA:
undetectable		 2izqA-5mulA:
2.74
2izqB-5mulA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 ALA A 275
VAL A 337
TRP A 391
 None
 0.93A 2izqA-5mvhA:
undetectable
2izqB-5mvhA:
undetectable		 2izqA-5mvhA:
3.00
2izqB-5mvhA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ALA A 166
VAL A 213
TRP A 229
 None
 0.69A 2izqA-5n28A:
undetectable
2izqB-5n28A:
undetectable		 2izqA-5n28A:
2.32
2izqB-5n28A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 3 ALA A 168
VAL A 120
TRP A 116
 None
 0.96A 2izqA-5ndxA:
undetectable
2izqB-5ndxA:
undetectable		 2izqA-5ndxA:
undetectable
2izqB-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 3 ALA A 226
VAL A 228
TRP A 224
 None
 0.94A 2izqA-5o82A:
undetectable
2izqB-5o82A:
undetectable		 2izqA-5o82A:
undetectable
2izqB-5o82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okz EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		3 ALA H 117
VAL H 119
TRP H 124
 None
 0.83A 2izqA-5okzH:
undetectable
2izqB-5okzH:
undetectable		 2izqA-5okzH:
5.08
2izqB-5okzH:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB

(Escherichia
coli) 		no annotation 3 ALA B  19
VAL B  22
TRP B 150
 None
 0.81A 2izqA-5sv0B:
undetectable
2izqB-5sv0B:
undetectable		 2izqA-5sv0B:
8.73
2izqB-5sv0B:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo sapiens) 		PF08210
(APOBEC_N) 		3 ALA A  67
VAL A  59
TRP A  94
 None
 0.74A 2izqA-5tkmA:
undetectable
2izqB-5tkmA:
undetectable		 2izqA-5tkmA:
6.54
2izqB-5tkmA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		3 ALA A 281
VAL A 298
TRP A 283
 None
 0.96A 2izqA-5uaoA:
undetectable
2izqB-5uaoA:
undetectable		 2izqA-5uaoA:
2.40
2izqB-5uaoA:
2.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 3 ALA D 211
VAL D 218
TRP D 201
 None
 0.91A 2izqA-5ui3D:
undetectable
2izqB-5ui3D:
undetectable		 2izqA-5ui3D:
undetectable
2izqB-5ui3D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		3 ALA A  63
VAL A  66
TRP A  59
 None
 0.83A 2izqA-5uldA:
undetectable
2izqB-5uldA:
undetectable		 2izqA-5uldA:
2.97
2izqB-5uldA:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 ALA A 272
VAL A 321
TRP A 305
 None
None
P5F  A1001 (-3.7A)
 0.93A 2izqA-5ur2A:
undetectable
2izqB-5ur2A:
undetectable		 2izqA-5ur2A:
2.82
2izqB-5ur2A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN

(Thermus
aquaticus) 		PF03781
(FGE-sulfatase) 		3 ALA A  90
VAL A 373
TRP A 201
 None
 0.74A 2izqA-5vf4A:
undetectable
2izqB-5vf4A:
undetectable		 2izqA-5vf4A:
6.06
2izqB-5vf4A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlq LOC100158544 PROTEIN

(Xenopus
tropicalis) 		PF03133
(TTL) 		3 ALA A 473
VAL A 476
TRP A 471
 None
 0.95A 2izqA-5vlqA:
undetectable
2izqB-5vlqA:
undetectable		 2izqA-5vlqA:
3.21
2izqB-5vlqA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsx CHITINASE

(Thermococcus
chitonophagus) 		no annotation 3 ALA A 646
VAL A 680
TRP A 682
 None
 0.89A 2izqA-5xsxA:
undetectable
2izqB-5xsxA:
undetectable		 2izqA-5xsxA:
undetectable
2izqB-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a2f -

(-) 		no annotation 3 ALA A 326
VAL A 330
TRP A 324
 None
 0.89A 2izqA-6a2fA:
undetectable
2izqB-6a2fA:
undetectable		 2izqA-6a2fA:
undetectable
2izqB-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8

(Homo sapiens) 		no annotation 3 ALA A 360
VAL A 357
TRP A 358
 None
 0.94A 2izqA-6bszA:
undetectable
2izqB-6bszA:
undetectable		 2izqA-6bszA:
undetectable
2izqB-6bszA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 3 ALA A 249
VAL A 294
TRP A 254
 None
 0.96A 2izqA-6d35A:
undetectable
2izqB-6d35A:
undetectable		 2izqA-6d35A:
undetectable
2izqB-6d35A:
undetectable