SIMILAR PATTERNS OF AMINO ACIDS FOR 2IYF_B_ERYB1399

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		5 VAL A  63
ILE A 113
LEU A  73
ALA A 105
ASP A  68
 None
 1.37A 2iyfB-1bheA:
undetectable		 2iyfB-1bheA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASN A 266
VAL A 265
ILE A 262
ALA A 162
ASP A 247
 None
 1.16A 2iyfB-1bxzA:
5.9		 2iyfB-1bxzA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 PHE A 310
ASN A 207
TYR A 179
SER A 204
ASP A 292
 None
None
None
None
CA  A 502 (-2.5A)
 1.37A 2iyfB-1cvrA:
4.1		 2iyfB-1cvrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00106
(adh_short) 		5 ASN A  90
LEU A 205
TYR A 168
ALA A 197
SER A 155
 None
NAD  A 301 (-3.6A)
NAD  A 301 (-4.5A)
None
NAD  A 301 ( 3.9A)
 1.41A 2iyfB-1e6wA:
6.4		 2iyfB-1e6wA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 VAL A 314
ILE A 303
LEU A 266
ALA A 318
SER A 301
 VAL  A 314 ( 0.6A)
ILE  A 303 ( 0.7A)
LEU  A 266 ( 0.6A)
ALA  A 318 ( 0.0A)
SER  A 301 ( 0.0A)
 1.28A 2iyfB-1fxjA:
2.4		 2iyfB-1fxjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ib1 14-3-3 ZETA ISOFORM

(Homo sapiens) 		PF00244
(14-3-3) 		5 TRP A  59
ILE A 141
LEU A  98
SER A 145
ASP A  92
 None
 1.33A 2iyfB-1ib1A:
undetectable		 2iyfB-1ib1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr1 HEVAMINE A

(Hevea
brasiliensis) 		PF00704
(Glyco_hydro_18) 		5 ASN A  29
TYR A  85
LEU A 170
ALA A 127
ASP A 176
 None
 1.33A 2iyfB-1kr1A:
2.2		 2iyfB-1kr1A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzl RIBOFLAVIN SYNTHASE

(Schizosaccharomyces
pombe) 		PF00677
(Lum_binding) 		5 VAL A   6
ASN A  72
LEU A  73
ALA A 141
ASP A  80
 CRM  A 501 (-4.0A)
None
None
None
None
 1.41A 2iyfB-1kzlA:
undetectable		 2iyfB-1kzlA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqi 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Rattus
norvegicus) 		PF00903
(Glyoxalase) 		5 VAL A  70
PHE A  24
LEU A 170
TYR A 165
ALA A  29
 None
 1.28A 2iyfB-1sqiA:
undetectable		 2iyfB-1sqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		5 PHE A 358
ASN A 350
LEU A 448
ALA A 420
SER A 402
 None
 1.33A 2iyfB-1thgA:
2.5		 2iyfB-1thgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjl ANNEXIN A2

(Homo sapiens) 		PF00191
(Annexin) 		5 ILE A 291
TYR A 109
LEU A 315
SER A 296
ASP A 322
 None
None
None
None
CA  A 345 (-2.2A)
 1.40A 2iyfB-1xjlA:
undetectable		 2iyfB-1xjlA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjl ANNEXIN A2

(Homo sapiens) 		PF00191
(Annexin) 		5 VAL A  98
ILE A 291
TYR A 109
LEU A 315
SER A 296
 None
 1.42A 2iyfB-1xjlA:
undetectable		 2iyfB-1xjlA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASN A 401
LEU A 256
TYR A 532
ALA A 480
SER A 479
 None
 1.41A 2iyfB-1xkhA:
undetectable		 2iyfB-1xkhA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN

(Homo sapiens) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 PHE A  51
ILE A   6
LEU A 157
ALA A  64
ASP A 200
 None
 1.39A 2iyfB-1z5vA:
4.6		 2iyfB-1z5vA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 ILE A 170
TYR A 128
ASN A 174
LEU A 201
ASP A 203
 None
 1.40A 2iyfB-2a7sA:
undetectable		 2iyfB-2a7sA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 VAL A 866
ILE A 830
TYR A 891
LEU A 736
ALA A 882
 None
 1.30A 2iyfB-2b5mA:
undetectable		 2iyfB-2b5mA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 TRP B  32
ILE B 140
LEU B  86
SER B  92
ASP B  71
 None
None
MMC  B1500 ( 4.5A)
None
None
 1.26A 2iyfB-2d2nB:
undetectable		 2iyfB-2d2nB:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddx BETA-1,3-XYLANASE

(Vibrio sp. AX-4) 		no annotation 5 ASN A  80
ILE A  95
LEU A 111
ALA A  87
SER A 132
 None
 1.18A 2iyfB-2ddxA:
undetectable		 2iyfB-2ddxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 TYR A 661
ASN A 692
LEU A 689
TYR A 253
ALA A 256
 None
 1.24A 2iyfB-2ecfA:
5.6		 2iyfB-2ecfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Aquifex
aeolicus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ASN A 135
VAL A 134
TYR A 269
LEU A 330
SER A 299
 None
 1.06A 2iyfB-2ep7A:
5.4		 2iyfB-2ep7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 PHE A 124
TYR A 125
LEU A 164
TYR A 135
ALA A 111
 None
 1.44A 2iyfB-2i3aA:
3.5		 2iyfB-2i3aA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		5 VAL A 222
ILE A 239
ASN A  45
LEU A  46
ALA A 199
 None
 1.24A 2iyfB-2i62A:
2.2		 2iyfB-2i62A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 ASN A 645
ILE A 624
TYR A 539
LEU A 456
ALA A 621
 None
 1.43A 2iyfB-2iuuA:
undetectable		 2iyfB-2iuuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ASN X 166
ASN X 330
LEU X 294
ALA X 288
ASP X 459
 None
 1.36A 2iyfB-2iv2X:
3.1		 2iyfB-2iv2X:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		11 TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
LEU A 134
TYR A 140
ALA A 182
SER A 183
 ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.8A)
ERY  A1400 ( 4.5A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
 0.27A 2iyfB-2iyfA:
58.7		 2iyfB-2iyfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		11 TRP A  73
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
LEU A 134
TYR A 140
ALA A 182
SER A 183
ASP A 329
 ERY  A1400 (-3.8A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.8A)
ERY  A1400 ( 4.5A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
ERY  A1400 (-4.7A)
 0.77A 2iyfB-2iyfA:
58.7		 2iyfB-2iyfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN

(Shewanella
oneidensis) 		PF08933
(DUF1864) 		5 ASN A  80
VAL A  81
TYR A 224
ASN A  23
LEU A  22
 None
 1.14A 2iyfB-2nwbA:
undetectable		 2iyfB-2nwbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2

(Plasmodium
vivax) 		PF00268
(Ribonuc_red_sm) 		5 ASN A 250
VAL A 247
TYR A 236
ALA A 181
SER A 179
 None
 1.31A 2iyfB-2o1zA:
undetectable		 2iyfB-2o1zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 VAL A 314
ILE A 303
LEU A 266
ALA A 318
SER A 301
 None
 1.25A 2iyfB-2oi6A:
undetectable		 2iyfB-2oi6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASN A 333
ILE A  33
LEU A 361
ALA A 302
ASP A 356
 None
 1.30A 2iyfB-2p88A:
undetectable		 2iyfB-2p88A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		5 ASN A 441
VAL A 440
TYR A 511
LEU A 379
ASP A 374
 None
 1.42A 2iyfB-2pfvA:
undetectable		 2iyfB-2pfvA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 TRP A 218
ASN A 148
PHE A  34
ILE A  12
ALA A  23
 None
 1.29A 2iyfB-2po4A:
undetectable		 2iyfB-2po4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 ILE A 193
TYR A 239
LEU A 216
ALA A 196
ASP A 183
 None
 1.45A 2iyfB-2r5gA:
undetectable		 2iyfB-2r5gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyg 3-DEHYDROQUINATE
DEHYDRATASE

(Thermus
thermophilus) 		PF01220
(DHquinase_II) 		5 VAL A  95
ILE A   4
ASN A   6
LEU A  10
ALA A 134
 None
None
None
GOL  A1143 (-4.6A)
None
 1.43A 2iyfB-2uygA:
3.9		 2iyfB-2uygA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		5 ASN A  18
VAL A  17
LEU A 214
ALA A  14
ASP A 217
 None
 1.43A 2iyfB-2yp1A:
undetectable		 2iyfB-2yp1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		5 ASN A 545
VAL A 562
LEU A 515
SER A 534
ASP A 591
 None
 1.31A 2iyfB-2ztgA:
undetectable		 2iyfB-2ztgA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 VAL A 188
ILE A 226
TYR A 243
TYR A 215
SER A 199
 None
 1.36A 2iyfB-3al9A:
undetectable		 2iyfB-3al9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		5 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.12A 2iyfB-3apoA:
3.5		 2iyfB-3apoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apq DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		5 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.15A 2iyfB-3apqA:
2.9		 2iyfB-3apqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhi CARBONYL REDUCTASE
[NADPH] 1

(Homo sapiens) 		PF00106
(adh_short) 		5 ASN A 136
VAL A 135
LEU A  61
ALA A   7
ASP A 119
 None
 1.39A 2iyfB-3bhiA:
6.1		 2iyfB-3bhiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 VAL A 301
ILE A 357
LEU A 408
ALA A 331
ASP A 263
 None
 1.43A 2iyfB-3ce6A:
undetectable		 2iyfB-3ce6A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA

(Methylosinus
trichosporium) 		PF02461
(AMO) 		5 PHE B  46
TYR B  42
ASN B 164
LEU B 160
ALA B  77
 None
 1.39A 2iyfB-3chxB:
undetectable		 2iyfB-3chxB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyt UNCHARACTERIZED
PROTEIN SPOA0173

(Ruegeria
pomeroyi) 		PF00578
(AhpC-TSA) 		5 ASN A  13
ILE A  30
LEU A  23
ALA A  48
ASP A  17
 None
None
None
None
EDO  A 201 (-2.8A)
 1.42A 2iyfB-3eytA:
3.1		 2iyfB-3eytA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASN A 590
VAL A 589
TYR A 548
ASN A 479
ALA A 566
 None
 1.24A 2iyfB-3fawA:
undetectable		 2iyfB-3fawA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		5 VAL A 257
ILE A 286
LEU A 103
ALA A 122
SER A 300
 None
 1.35A 2iyfB-3fcrA:
2.1		 2iyfB-3fcrA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		PF00912
(Transgly) 		5 ASN A 224
VAL A 223
ILE A 231
LEU A 214
ALA A 192
 M0E  A 901 (-3.9A)
M0E  A 901 (-4.8A)
None
None
None
 1.27A 2iyfB-3hzsA:
undetectable		 2iyfB-3hzsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5q NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		no annotation 5 ASN B1441
ILE B1412
TYR B1399
LEU B1451
SER B1409
 None
 1.29A 2iyfB-3i5qB:
undetectable		 2iyfB-3i5qB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9f PUTATIVE TYPE 11
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF08241
(Methyltransf_11) 		5 ASN A 161
ILE A 123
TYR A  45
TYR A 147
ALA A  96
 None
 1.40A 2iyfB-3i9fA:
3.6		 2iyfB-3i9fA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		5 VAL A  10
PHE A 279
ILE A   7
LEU A 392
ASP A 368
 None
None
None
None
GOL  A 401 (-2.8A)
 1.45A 2iyfB-3m8yA:
undetectable		 2iyfB-3m8yA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN

(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		no annotation
PF02136
(NTF2) 		5 VAL A 365
ILE A 303
LEU A 380
ALA A 242
ASP B  79
 None
None
None
None
NA  B 452 (-3.4A)
 1.42A 2iyfB-3nv0A:
undetectable		 2iyfB-3nv0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 VAL A 188
ILE A 226
TYR A 243
TYR A 215
SER A 199
 None
 1.39A 2iyfB-3okyA:
undetectable		 2iyfB-3okyA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 VAL A 611
ILE A 658
TYR A 587
LEU A 631
ALA A 588
 None
 1.41A 2iyfB-3pihA:
undetectable		 2iyfB-3pihA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASN A 151
VAL A 149
LEU A 358
TYR A 415
ASP A  45
 None
 1.44A 2iyfB-3qlbA:
undetectable		 2iyfB-3qlbA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smv S-(-)-AZETIDINE-2-CA
RBOXYLATE HYDROLASE

(Pseudomonas sp.
AC2) 		PF13419
(HAD_2) 		5 ILE A 142
ASN A 132
LEU A 135
TYR A  14
SER A 121
 None
 1.38A 2iyfB-3smvA:
5.8		 2iyfB-3smvA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sok FIMBRIAL PROTEIN

(Dichelobacter
nodosus) 		PF00114
(Pilin)
PF07963
(N_methyl) 		5 ASN A 134
VAL A 122
ILE A  47
ASN A  95
ALA A  40
 None
 1.45A 2iyfB-3sokA:
undetectable		 2iyfB-3sokA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svi TYPE III EFFECTOR
HOPAB2

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 VAL A 185
PHE A 186
ASN A 162
SER A 179
ASP A 216
 None
 1.26A 2iyfB-3sviA:
undetectable		 2iyfB-3sviA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjy EFFECTOR PROTEIN
HOPAB3

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 VAL A 185
PHE A 186
ASN A 162
SER A 179
ASP A 216
 None
 1.22A 2iyfB-3tjyA:
undetectable		 2iyfB-3tjyA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		5 TRP A 255
PHE A 232
ILE A 271
TYR A 233
ASP A 311
 None
None
None
ARG  A 806 (-4.5A)
None
 1.33A 2iyfB-3w5fA:
undetectable		 2iyfB-3w5fA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		5 ASN A  18
TYR A  24
LEU A 162
TYR A 207
ALA A 215
 None
 1.20A 2iyfB-3x0uA:
undetectable		 2iyfB-3x0uA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASN A 293
VAL A 290
ILE A 562
TYR A 552
ALA A 564
 None
 0.89A 2iyfB-4b56A:
undetectable		 2iyfB-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		5 ASN I 381
ILE I 213
ASN I 238
ALA I 296
ASP I 245
 B12  I1631 (-3.9A)
None
None
None
None
 1.39A 2iyfB-4c1nI:
undetectable		 2iyfB-4c1nI:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di3 TATT (TP0956)

(Treponema
pallidum) 		PF16811
(TAtT) 		5 ASN A 278
VAL A 282
ASN A 204
LEU A 231
ALA A 267
 None
 1.10A 2iyfB-4di3A:
undetectable		 2iyfB-4di3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		5 PHE A 130
ILE A  93
LEU A 308
ALA A  99
ASP A  83
 None
 1.26A 2iyfB-4dppA:
undetectable		 2iyfB-4dppA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF07993
(NAD_binding_4) 		5 VAL A 151
PHE A 188
ILE A 179
LEU A 135
ASP A 127
 None
 1.17A 2iyfB-4dqvA:
5.9		 2iyfB-4dqvA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		5 VAL A 182
ILE A 321
LEU A 315
ALA A 375
ASP A 220
 None
 1.44A 2iyfB-4fwmA:
undetectable		 2iyfB-4fwmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV

(Borreliella
burgdorferi) 		PF00496
(SBP_bac_5) 		5 PHE A 442
TYR A 459
LEU A 347
TYR A 343
ALA A 482
 None
 1.35A 2iyfB-4gl8A:
undetectable		 2iyfB-4gl8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 ILE A 307
ASN A 309
ALA A 185
SER A 231
ASP A 296
 None
 1.38A 2iyfB-4iglA:
undetectable		 2iyfB-4iglA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4klk PHAGE-RELATED
PROTEIN DUF2815

(Enterococcus
faecalis) 		PF10991
(DUF2815) 		5 ASN A 102
VAL A 103
ILE A  56
LEU A  49
ASP A  82
 None
 1.28A 2iyfB-4klkA:
undetectable		 2iyfB-4klkA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 ASN A1334
VAL A1331
ILE A1357
LEU A1305
ALA A1359
 None
 1.37A 2iyfB-4ll8A:
undetectable		 2iyfB-4ll8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9r CELL DEATH PROTEIN 3

(Caenorhabditis
elegans) 		PF00656
(Peptidase_C14) 		5 PHE A 469
ILE A 438
LEU A 272
ALA A 420
ASP A 216
 None
 1.29A 2iyfB-4m9rA:
3.2		 2iyfB-4m9rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9r CELL DEATH PROTEIN 3

(Caenorhabditis
elegans) 		PF00656
(Peptidase_C14) 		5 VAL A 465
PHE A 469
LEU A 272
ALA A 420
ASP A 216
 None
 1.23A 2iyfB-4m9rA:
3.2		 2iyfB-4m9rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhb PUTATIVE ALDO/KETO
REDUCTASE

(Yersinia pestis) 		PF00248
(Aldo_ket_red) 		5 ASN A 170
VAL A 169
ILE A 165
ALA A 145
ASP A 158
 None
 1.27A 2iyfB-4mhbA:
undetectable		 2iyfB-4mhbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mix PUTATIVE
INSECTICIDAL TOXIN

(Photorhabdus
asymbiotica) 		PF04488
(Gly_transf_sug) 		5 ASN A2180
ILE A2171
TYR A2274
ALA A2256
SER A2259
 None
UD1  A2502 (-4.2A)
None
UD1  A2502 (-3.6A)
UD1  A2502 (-2.9A)
 1.44A 2iyfB-4mixA:
2.3		 2iyfB-4mixA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npl RNA DEMETHYLASE
ALKBH5

(Danio rerio) 		PF13532
(2OG-FeII_Oxy_2) 		5 VAL A  42
ILE A 211
LEU A 102
ALA A 209
ASP A  97
 None
 0.98A 2iyfB-4nplA:
undetectable		 2iyfB-4nplA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		5 ILE A 244
LEU A 261
TYR A  23
ALA A 231
SER A 229
 None
None
NAD  A 401 (-4.9A)
NAD  A 401 (-3.2A)
NAD  A 401 (-2.7A)
 1.31A 2iyfB-4o1mA:
5.5		 2iyfB-4o1mA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		5 PHE A 298
TYR A 109
LEU A 208
ALA A 231
ASP A 206
 None
 1.34A 2iyfB-4o8mA:
undetectable		 2iyfB-4o8mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 ASN A 174
VAL A 175
ILE A 238
LEU A 215
ALA A 107
 None
CS2  A 401 (-4.6A)
CS2  A 401 (-4.9A)
CS2  A 401 (-4.2A)
None
 1.31A 2iyfB-4pc9A:
undetectable		 2iyfB-4pc9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 VAL A 219
ILE A 107
LEU A 209
ALA A 127
ASP A 214
 None
 1.28A 2iyfB-4rncA:
4.0		 2iyfB-4rncA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		5 ILE A  76
TYR A  84
ALA A  72
SER A  71
ASP A  95
 None
 1.44A 2iyfB-4rv3A:
undetectable		 2iyfB-4rv3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 ASN L 551
TYR L 502
TYR L 414
SER L 437
ASP L 542
 NA  L 705 (-3.3A)
None
None
None
NA  L 706 (-2.8A)
 1.15A 2iyfB-4tkxL:
3.2		 2iyfB-4tkxL:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		5 ILE A 579
TYR A 619
LEU A 660
ALA A 577
ASP A 341
 None
 1.33A 2iyfB-4xjxA:
undetectable		 2iyfB-4xjxA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1k OUTER MEMBRANE
PROTEIN OPRM

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 ILE A 275
LEU A 446
TYR A  18
ALA A  12
ASP A  37
 None
 1.32A 2iyfB-4y1kA:
undetectable		 2iyfB-4y1kA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
FAD-BINDING SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ASN B 213
ILE B 207
LEU B 267
TYR B 176
ALA B 125
 None
 1.40A 2iyfB-4zohB:
undetectable		 2iyfB-4zohB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
FAD-BINDING SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 VAL B 166
ILE B 124
LEU B 113
ALA B 122
ASP B 154
 None
 1.28A 2iyfB-4zohB:
undetectable		 2iyfB-4zohB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		5 PHE A 362
LEU A 321
ALA A  44
SER A 318
ASP A  56
 None
 1.25A 2iyfB-4zxoA:
undetectable		 2iyfB-4zxoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ASN A 155
VAL A 156
ILE A 190
SER A 250
ASP A  95
 None
None
None
None
ZN  A1903 ( 2.1A)
 1.35A 2iyfB-5a7mA:
4.4		 2iyfB-5a7mA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		5 VAL A 325
ILE A 342
LEU A 347
ALA A 374
SER A 375
 None
 1.31A 2iyfB-5eefA:
2.1		 2iyfB-5eefA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		5 ASN A 299
ILE A 324
TYR A 344
ALA A 184
SER A 185
 None
 1.38A 2iyfB-5fa1A:
5.2		 2iyfB-5fa1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 VAL A  37
PHE A  50
TYR A  52
ASN A  64
ASP A  24
 None
 1.33A 2iyfB-5i2tA:
undetectable		 2iyfB-5i2tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 PHE A 542
ILE A 605
LEU A 708
TYR A 781
ASP A 714
 None
 1.41A 2iyfB-5jcfA:
undetectable		 2iyfB-5jcfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 ASN A 154
ILE A  81
LEU A 256
TYR A 219
ALA A 248
 None
NAD  A 901 (-3.8A)
NAD  A 901 (-3.6A)
NAD  A 901 (-4.6A)
None
 1.32A 2iyfB-5jydA:
5.8		 2iyfB-5jydA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 VAL A 188
ILE A 226
TYR A 243
TYR A 215
SER A 199
 None
 1.36A 2iyfB-5l5gA:
undetectable		 2iyfB-5l5gA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szn PROTOCADHERIN GAMMA
A9

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 VAL A 130
TYR A 142
ASN A  99
ALA A 186
SER A 196
 None
None
CA  A 615 (-3.4A)
None
None
 1.29A 2iyfB-5sznA:
undetectable		 2iyfB-5sznA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t38 EVDMO1

(Micromonospora
carbonacea) 		PF13847
(Methyltransf_31) 		5 ILE A 152
LEU A  61
ALA A 150
SER A 149
ASP A  68
 None
None
None
None
SAH  A 301 ( 4.8A)
 1.43A 2iyfB-5t38A:
3.3		 2iyfB-5t38A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4m PROTOCADHERIN-15

(Homo sapiens) 		PF00028
(Cadherin) 		5 VAL A 513
TYR A 525
ASN A 482
ALA A 564
SER A 576
 None
None
CA  A 705 (-3.0A)
None
None
 1.44A 2iyfB-5t4mA:
undetectable		 2iyfB-5t4mA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwz ALDEHYDE
DECARBONYLASE

(Gloeobacter
violaceus) 		no annotation 5 PHE A  68
ILE A  25
LEU A 182
ALA A  27
ASP A 202
 STE  A 303 (-4.3A)
STE  A 303 (-4.2A)
None
None
None
 1.39A 2iyfB-5uwzA:
undetectable		 2iyfB-5uwzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 ASN A  88
VAL A  89
ASN A 615
LEU A 612
ALA A  37
 None
 1.14A 2iyfB-5wugA:
2.5		 2iyfB-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 6 ASN A 153
VAL A 152
TYR A 144
LEU A 189
ALA A 104
SER A 135
 None
 1.41A 2iyfB-6avyA:
3.5		 2iyfB-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 ASN A 209
VAL A 164
TYR A  50
LEU A 193
ALA A 230
 None
 1.38A 2iyfB-6c4gA:
undetectable		 2iyfB-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea;
Spinacia
oleracea) 		no annotation
no annotation 		5 ASN D 240
TYR C 261
LEU C 305
TYR C 252
ALA C 244
 None
 1.26A 2iyfB-6fkhD:
undetectable		 2iyfB-6fkhD:
undetectable