SIMILAR PATTERNS OF AMINO ACIDS FOR 2IYF_A_ERYA1400

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASN A 266
VAL A 265
ILE A 262
ALA A 162
ASP A 247
 None
 1.03A 2iyfA-1bxzA:
4.5		 2iyfA-1bxzA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 ASN A 500
VAL A 499
ILE A 496
TYR A 490
ASP A 201
 None
 1.49A 2iyfA-1gjuA:
0.9		 2iyfA-1gjuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzc ERYTHRINA
CRISTA-GALLI LECTIN

(Erythrina
crista-galli) 		PF00139
(Lectin_legB) 		5 PHE A 158
TYR A 192
ALA A 190
SER A 188
ASP A 227
 None
 1.19A 2iyfA-1gzcA:
undetectable		 2iyfA-1gzcA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		5 ASN A 487
VAL A 369
ILE A 476
TYR A 382
ALA A 498
 None
 1.44A 2iyfA-1kspA:
undetectable		 2iyfA-1kspA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 HIS A 709
ASN A 853
VAL A 781
ILE A 857
ALA A 777
 FE2  A 858 ( 3.4A)
None
None
None
None
 1.48A 2iyfA-1rrhA:
undetectable		 2iyfA-1rrhA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		5 ASN A 151
VAL A 157
ILE A 226
ASN A 145
ALA A 161
 None
 1.49A 2iyfA-1vfnA:
1.2		 2iyfA-1vfnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 TRP A 390
VAL A 345
ILE A 179
SER A 101
ASP A 416
 None
 1.38A 2iyfA-1wmrA:
undetectable		 2iyfA-1wmrA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		11 HIS A  19
TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
ALA A 182
SER A 183
ASP A 329
 ERY  A1400 (-3.9A)
ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
ERY  A1400 (-4.7A)
 0.02A 2iyfA-2iyfA:
63.9		 2iyfA-2iyfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1z RIBONUCLEOTIDE
REDUCTASE SUBUNIT R2

(Plasmodium
vivax) 		PF00268
(Ribonuc_red_sm) 		5 ASN A 250
VAL A 247
TYR A 236
ALA A 181
SER A 179
 None
 1.30A 2iyfA-2o1zA:
undetectable		 2iyfA-2o1zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 TRP A 218
ASN A 148
PHE A  34
ILE A  12
ALA A  23
 None
 1.32A 2iyfA-2po4A:
undetectable		 2iyfA-2po4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 VAL A 410
PHE A 413
ILE A 397
ALA A 462
ASP A 471
 None
None
None
None
A16  A1722 (-3.4A)
 1.19A 2iyfA-2vr5A:
undetectable		 2iyfA-2vr5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhm NUCLEOPROTEIN

(Human
orthopneumovirus) 		PF03246
(Pneumo_ncap) 		5 VAL A  95
ILE A  33
ALA A 117
SER A 118
ASP A  78
 None
 1.45A 2iyfA-2yhmA:
undetectable		 2iyfA-2yhmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		5 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.09A 2iyfA-3apoA:
3.6		 2iyfA-3apoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apq DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		5 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.13A 2iyfA-3apqA:
undetectable		 2iyfA-3apqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ASN A 138
VAL A 134
ILE A 121
TYR A 322
ASP A 146
 None
None
None
NAD  A 340 ( 3.6A)
None
 1.44A 2iyfA-3b20A:
6.7		 2iyfA-3b20A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dte IRRE PROTEIN

(Deinococcus
deserti) 		PF06114
(Peptidase_M78) 		5 ASN A 117
VAL A 118
ILE A  84
ALA A  22
ASP A  55
 None
 1.40A 2iyfA-3dteA:
undetectable		 2iyfA-3dteA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		5 HIS A  52
ASN A  59
VAL A  58
ILE A  51
ALA A  15
 None
 1.28A 2iyfA-3e03A:
4.9		 2iyfA-3e03A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASN A 590
VAL A 589
TYR A 548
ASN A 479
ALA A 566
 None
 1.23A 2iyfA-3fawA:
undetectable		 2iyfA-3fawA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASN A 266
VAL A 265
ILE A 262
ALA A 162
ASP A 247
 None
 1.23A 2iyfA-3fplA:
2.3		 2iyfA-3fplA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihk THIAMIN
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 ASN A 108
PHE A 135
TYR A 200
ALA A 157
ASP A 128
 None
 1.48A 2iyfA-3ihkA:
undetectable		 2iyfA-3ihkA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ja6 CHEMOTAXIS PROTEIN
CHEW

(Escherichia
coli) 		PF01584
(CheW) 		5 ASN A  64
VAL A  63
ILE A  82
ALA A  84
ASP A  19
 None
 1.23A 2iyfA-3ja6A:
undetectable		 2iyfA-3ja6A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		5 TRP A 202
ASN A 177
PHE A  64
ILE A 195
TYR A  44
 None
None
GOL  A 438 (-4.8A)
None
None
 1.28A 2iyfA-3k1tA:
undetectable		 2iyfA-3k1tA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 ASN A 211
ILE A 296
TYR A 323
ALA A 302
ASP A 287
 None
 1.42A 2iyfA-3ombA:
undetectable		 2iyfA-3ombA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		5 HIS A  22
VAL A  93
ALA A 247
SER A 248
ASP A 105
 None
 1.21A 2iyfA-3phgA:
5.7		 2iyfA-3phgA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6y ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1) 		5 HIS A 150
ASN A 359
PHE A 366
ASN A 226
ASP A 266
 HIS  A 150 ( 1.0A)
ASN  A 359 ( 0.6A)
PHE  A 366 ( 1.3A)
ASN  A 226 ( 0.6A)
ASP  A 266 ( 0.6A)
 1.22A 2iyfA-3r6yA:
undetectable		 2iyfA-3r6yA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sok FIMBRIAL PROTEIN

(Dichelobacter
nodosus) 		PF00114
(Pilin)
PF07963
(N_methyl) 		5 ASN A 134
VAL A 122
ILE A  47
ASN A  95
ALA A  40
 None
 1.46A 2iyfA-3sokA:
undetectable		 2iyfA-3sokA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teb ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Leptotrichia
buccalis) 		PF03372
(Exo_endo_phos) 		5 HIS A 254
ASN A  41
VAL A  40
ALA A  36
SER A 138
 None
 1.48A 2iyfA-3tebA:
undetectable		 2iyfA-3tebA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		5 ASN X 381
ILE X 213
ASN X 238
ALA X 296
ASP X 245
 PO4  X 801 (-4.5A)
None
None
None
None
 1.44A 2iyfA-3zyyX:
undetectable		 2iyfA-3zyyX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASN A 293
VAL A 290
ILE A 562
TYR A 552
ALA A 564
 None
 0.87A 2iyfA-4b56A:
undetectable		 2iyfA-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		5 TRP A 299
PHE A 415
ALA A 417
SER A 499
ASP A 228
 None
 1.50A 2iyfA-4el8A:
undetectable		 2iyfA-4el8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exl PHOSPHATE-BINDING
PROTEIN PSTS 1

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		5 ASN A  84
VAL A  36
ALA A  79
SER A  77
ASP A 102
 None
 1.49A 2iyfA-4exlA:
undetectable		 2iyfA-4exlA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		5 TRP A 185
ASN A 186
ALA A  73
SER A  71
ASP A  14
 None
CA  A 401 ( 4.3A)
None
None
None
 1.27A 2iyfA-4i70A:
3.4		 2iyfA-4i70A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8b COATOMER ALPHA
SUBUNIT

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		5 ASN A  78
VAL A  69
PHE A  68
ALA A  18
ASP A  53
 None
 1.27A 2iyfA-4j8bA:
undetectable		 2iyfA-4j8bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 ASN A 234
ILE A 261
ALA A 254
SER A 252
ASP A 240
 None
None
FAD  A 401 (-3.3A)
FAD  A 401 (-2.5A)
None
 1.32A 2iyfA-4kpuA:
5.2		 2iyfA-4kpuA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 HIS B  79
ASN B  59
VAL B  58
ASN B  77
ALA B  55
 None
 1.40A 2iyfA-4nt9B:
undetectable		 2iyfA-4nt9B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		5 ASN A 129
VAL A 128
PHE A 147
ALA A  67
ASP A 142
 None
None
None
None
CO  A 301 ( 2.5A)
 1.35A 2iyfA-4ookA:
undetectable		 2iyfA-4ookA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc4 30K LIPOPROTEIN

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		5 ASN A  52
VAL A  49
TYR A  64
ALA A  30
SER A  21
 MES  A 302 (-3.3A)
None
None
None
None
 1.47A 2iyfA-4pc4A:
undetectable		 2iyfA-4pc4A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uou FUCOSE-SPECIFIC
LECTIN FLEA

(Aspergillus
fumigatus) 		PF07938
(Fungal_lectin) 		5 ASN A 235
VAL A 234
ILE A 231
ALA A 216
ASP A 207
 None
 1.38A 2iyfA-4uouA:
undetectable		 2iyfA-4uouA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 HIS A  41
VAL A  68
TYR A  58
ASN A 282
ALA A  62
 None
None
None
None
LLP  A 508 ( 4.8A)
 1.45A 2iyfA-4xg1A:
undetectable		 2iyfA-4xg1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		5 HIS A 296
ASN A 317
VAL A 487
ASN A 264
SER A 239
 None
 1.36A 2iyfA-5e7hA:
undetectable		 2iyfA-5e7hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo7 PREDICTED PROTEIN

(Aspergillus
oryzae) 		PF07938
(Fungal_lectin) 		5 ASN A 235
VAL A 234
ILE A 231
ALA A 216
ASP A 207
 None
 1.39A 2iyfA-5eo7A:
undetectable		 2iyfA-5eo7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 HIS A 317
TRP A 304
ASN A 608
VAL A 609
ILE A 322
 None
 1.48A 2iyfA-5f7sA:
undetectable		 2iyfA-5f7sA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		5 ASN A 299
ILE A 324
TYR A 344
ALA A 184
SER A 185
 None
 1.40A 2iyfA-5fa1A:
4.5		 2iyfA-5fa1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 HIS C 109
TYR C  52
ASN B 126
ALA C 127
SER C 128
 None
 1.15A 2iyfA-5g5gC:
undetectable		 2iyfA-5g5gC:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2

(Homo sapiens) 		no annotation 5 VAL A 637
ILE A 830
TYR A 648
SER A 835
ASP A 861
 None
 1.40A 2iyfA-5n7fA:
undetectable		 2iyfA-5n7fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szn PROTOCADHERIN GAMMA
A9

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 VAL A 130
TYR A 142
ASN A  99
ALA A 186
SER A 196
 None
None
CA  A 615 (-3.4A)
None
None
 1.28A 2iyfA-5sznA:
undetectable		 2iyfA-5sznA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4m PROTOCADHERIN-15

(Homo sapiens) 		PF00028
(Cadherin) 		5 VAL A 513
TYR A 525
ASN A 482
ALA A 564
SER A 576
 None
None
CA  A 705 (-3.0A)
None
None
 1.44A 2iyfA-5t4mA:
undetectable		 2iyfA-5t4mA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrw FLIN
FLIY

(Helicobacter
pylori;
Helicobacter
pylori) 		no annotation
no annotation 		5 ASN C 213
VAL C 251
ILE C 270
ALA C 257
ASP A  82
 None
 1.50A 2iyfA-5xrwC:
undetectable		 2iyfA-5xrwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 5 ASN A 153
VAL A 152
TYR A 144
ALA A 104
SER A 135
 None
 1.35A 2iyfA-6avyA:
4.6		 2iyfA-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfp VCA0883

(Vibrio cholerae) 		no annotation 5 ASN A 248
VAL A 245
ILE A 228
ALA A 230
ASP A 255
 None
 1.34A 2iyfA-6dfpA:
undetectable		 2iyfA-6dfpA:
undetectable