SIMILAR PATTERNS OF AMINO ACIDS FOR 2IWK_B_CUB1599_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ar1 CYTOCHROME C OXIDASE

(Paracoccus
denitrificans) 		PF00116
(COX2)
PF02790
(COX2_TM) 		3 CYH B 216
CYH B 220
HIS B 224
 CU  B 271 (-2.2A)
CU  B 270 (-2.1A)
CU  B 270 ( 3.2A)
 0.32A 2iwkB-1ar1B:
9.7		 2iwkB-1ar1B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyq INTRON-ENCODED
HOMING ENDONUCLEASE
I-PPOI

(Physarum
polycephalum) 		no annotation 3 CYH A  41
CYH A 100
HIS A 110
 ZN  A 602 (-2.3A)
ZN  A 602 (-2.3A)
ZN  A 602 (-3.2A)
 0.36A 2iwkB-1cyqA:
0.0		 2iwkB-1cyqA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyx CYOA

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		3 CYH A 207
CYH A 211
HIS A 215
 CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-2.8A)
 0.29A 2iwkB-1cyxA:
0.1		 2iwkB-1cyxA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		3 CYH A 143
CYH A 170
HIS A 169
 None
 0.75A 2iwkB-1de6A:
0.0		 2iwkB-1de6A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp0 KAP-1 COREPRESSOR

(Homo sapiens) 		PF00628
(PHD) 		3 CYH A  28
CYH A  51
HIS A  48
 ZN  A  90 (-2.3A)
ZN  A  90 (-2.2A)
ZN  A  90 (-2.7A)
 0.67A 2iwkB-1fp0A:
undetectable		 2iwkB-1fp0A:
7.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		3 CYH A 561
CYH A 565
HIS A 569
 CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-3.0A)
 0.11A 2iwkB-1fwxA:
70.6		 2iwkB-1fwxA:
85.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II

(Paracoccus
denitrificans) 		PF00116
(COX2)
PF02790
(COX2_TM) 		3 CYH B 216
CYH B 220
HIS B 224
 CUA  B 301 (-2.1A)
CUA  B 301 (-2.0A)
CUA  B 301 (-3.1A)
 0.36A 2iwkB-1qleB:
9.4		 2iwkB-1qleB:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.2A)
CUA  A 701 (-3.0A)
 0.17A 2iwkB-1qniA:
62.8		 2iwkB-1qniA:
59.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		3 CYH A 499
CYH A 510
HIS A 512
 ZN  A2131 (-2.3A)
ZN  A2131 (-2.4A)
ZN  A2131 (-2.8A)
 0.83A 2iwkB-1urjA:
0.0		 2iwkB-1urjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 CYH A  43
CYH A 166
HIS A  65
 ZN  A 401 (-2.5A)
ZN  A 401 (-3.0A)
ZN  A 401 (-3.4A)
 0.87A 2iwkB-1vj0A:
0.3		 2iwkB-1vj0A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
DELTA SUBUNIT

(Corynebacterium
sp. U-96) 		PF04267
(SoxD) 		3 CYH D   6
CYH D  63
HIS D  59
 ZN  D1006 (-2.4A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.68A 2iwkB-1vrqD:
2.1		 2iwkB-1vrqD:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
DELTA SUBUNIT

(Corynebacterium
sp. U-96) 		PF04267
(SoxD) 		3 CYH D   9
CYH D  63
HIS D  59
 ZN  D1006 (-2.3A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.57A 2iwkB-1vrqD:
2.1		 2iwkB-1vrqD:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wir PROTEIN ARGININE
N-METHYLTRANSFERASE
3

(Mus musculus) 		no annotation 3 CYH A  18
CYH A  35
HIS A  34
 ZN  A 201 (-2.3A)
ZN  A 201 ( 4.3A)
ZN  A 201 (-3.4A)
 0.88A 2iwkB-1wirA:
undetectable		 2iwkB-1wirA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo3 CREB BINDING PROTEIN

(Homo sapiens) 		no annotation 3 CYH A  23
CYH A  10
HIS A  19
 ZN  A  26 (-2.3A)
ZN  A  26 (-2.3A)
ZN  A  26 (-3.0A)
 0.88A 2iwkB-1wo3A:
undetectable		 2iwkB-1wo3A:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo5 CREB BINDING PROTEIN

(Homo sapiens) 		no annotation 3 CYH A  23
CYH A  10
HIS A  19
 ZN  A  26 (-2.3A)
ZN  A  26 (-2.3A)
ZN  A  26 (-3.0A)
 0.67A 2iwkB-1wo5A:
undetectable		 2iwkB-1wo5A:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo6 CREB BINDING PROTEIN

(Homo sapiens) 		no annotation 3 CYH A  23
CYH A  10
HIS A  19
 ZN  A  26 (-2.3A)
ZN  A  26 (-2.3A)
ZN  A  26 (-3.1A)
 0.87A 2iwkB-1wo6A:
undetectable		 2iwkB-1wo6A:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo7 CREB BINDING PROTEIN

(Homo sapiens) 		no annotation 3 CYH A  23
CYH A  10
HIS A  19
 ZN  A  26 (-2.3A)
ZN  A  26 (-2.3A)
ZN  A  26 (-3.1A)
 0.73A 2iwkB-1wo7A:
undetectable		 2iwkB-1wo7A:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8f UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1) 		3 CYH A 600
CYH A 616
HIS A 567
 ZN  A 701 (-2.3A)
ZN  A 701 (-2.5A)
ZN  A 701 (-3.3A)
 0.73A 2iwkB-1y8fA:
undetectable		 2iwkB-1y8fA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY

(Vibrio cholerae) 		PF00480
(ROK) 		3 CYH A 257
CYH A 262
HIS A 245
 ZN  A 406 (-2.3A)
ZN  A 406 (-2.2A)
ZN  A 406 (-3.2A)
 0.73A 2iwkB-1z05A:
undetectable		 2iwkB-1z05A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		3 CYH A 259
CYH A 264
HIS A 247
 ZN  A 501 (-2.2A)
ZN  A 501 (-2.2A)
ZN  A 501 (-3.0A)
 0.79A 2iwkB-1z6rA:
undetectable		 2iwkB-1z6rA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		3 CYH A 168
CYH A 173
HIS A 156
 ZN  A1001 (-2.2A)
ZN  A1001 (-2.2A)
ZN  A1001 (-3.2A)
 0.76A 2iwkB-2aa4A:
undetectable		 2iwkB-2aa4A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		3 CYH A 179
CYH A 184
HIS A 157
 ZN  A 304 (-2.3A)
ZN  A 304 (-2.3A)
ZN  A 304 (-3.2A)
 0.74A 2iwkB-2ap1A:
undetectable		 2iwkB-2ap1A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5l NONSTRUCTURAL
PROTEIN V

(Mammalian
rubulavirus 5) 		PF13008
(zf-Paramyx-P)
PF14313
(Soyouz_module) 		3 CYH C 215
CYH C 190
HIS C 171
 ZN  C3002 (-2.2A)
ZN  C3002 (-2.2A)
ZN  C3002 (-4.0A)
 0.76A 2iwkB-2b5lC:
undetectable		 2iwkB-2b5lC:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Moritella
profunda) 		PF01948
(PyrI)
PF02748
(PyrI_C) 		3 CYH D 108
CYH D 113
HIS D 116
 ZN  D1108 (-2.2A)
ZN  D1108 (-2.3A)
None
 0.75A 2iwkB-2be7D:
undetectable		 2iwkB-2be7D:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl6 NUCLEOCAPSID PROTEIN
P11

(Equine
infectious
anemia virus) 		PF00098
(zf-CCHC) 		3 CYH A  56
CYH A  46
HIS A  51
 ZN  A1060 (-2.1A)
ZN  A1060 (-2.1A)
ZN  A1060 (-3.3A)
 0.83A 2iwkB-2bl6A:
undetectable		 2iwkB-2bl6A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9m ZINC FINGER
CCCH-TYPE DOMAIN
CONTAINING PROTEIN
7A

(Homo sapiens) 		PF00642
(zf-CCCH) 		3 CYH A 915
CYH A 921
HIS A 925
 ZN  A1085 (-2.3A)
ZN  A1085 (-2.3A)
ZN  A1085 (-3.5A)
 0.80A 2iwkB-2d9mA:
undetectable		 2iwkB-2d9mA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj8 PROTEIN CBFA2T1

(Homo sapiens) 		PF01753
(zf-MYND) 		3 CYH A  29
CYH A  54
HIS A  50
 ZN  A 401 (-2.1A)
ZN  A 401 (-2.3A)
ZN  A 401 (-3.2A)
 0.83A 2iwkB-2dj8A:
undetectable		 2iwkB-2dj8A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
DELTA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF04267
(SoxD) 		3 CYH D   6
CYH D  63
HIS D  59
 ZN  D 101 (-2.2A)
ZN  D 101 (-2.2A)
ZN  D 101 (-3.2A)
 0.64A 2iwkB-2gahD:
2.0		 2iwkB-2gahD:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
DELTA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF04267
(SoxD) 		3 CYH D   9
CYH D  63
HIS D  59
 ZN  D 101 (-2.2A)
ZN  D 101 (-2.2A)
ZN  D 101 (-3.2A)
 0.66A 2iwkB-2gahD:
2.0		 2iwkB-2gahD:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jz8 UNCHARACTERIZED
PROTEIN BH09830

(Bartonella
henselae) 		PF10276
(zf-CHCC) 		3 CYH A  54
CYH A  27
HIS A  38
 ZN  A 150 (-2.1A)
ZN  A 150 (-2.1A)
ZN  A 150 (-3.1A)
 0.87A 2iwkB-2jz8A:
undetectable		 2iwkB-2jz8A:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyu HISTONE-LYSINE
N-METHYLTRANSFERASE
MLL

(Homo sapiens) 		PF00628
(PHD) 		3 CYH A  11
CYH A  38
HIS A  35
 ZN  A  81 (-2.3A)
ZN  A  81 (-2.4A)
ZN  A  81 (-3.1A)
 0.65A 2iwkB-2kyuA:
undetectable		 2iwkB-2kyuA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0b E3 UBIQUITIN-PROTEIN
LIGASE PRAJA-1

(Homo sapiens) 		PF13639
(zf-RING_2) 		3 CYH A  43
CYH A  69
HIS A  66
 ZN  A 143 (-2.4A)
ZN  A 143 (-2.4A)
ZN  A 143 (-3.1A)
 0.78A 2iwkB-2l0bA:
undetectable		 2iwkB-2l0bA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lq6 BROMODOMAIN-CONTAINI
NG PROTEIN 1

(Homo sapiens) 		PF13771
(zf-HC5HC2H) 		3 CYH A 346
CYH A 385
HIS A 388
 ZN  A 402 (-2.1A)
ZN  A 402 (-2.1A)
ZN  A 402 (-3.3A)
 0.81A 2iwkB-2lq6A:
undetectable		 2iwkB-2lq6A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxw XIAP-ASSOCIATED
FACTOR 1

(Homo sapiens) 		no annotation 3 CYH A  24
CYH A  40
HIS A  36
 ZN  A 101 (-1.9A)
ZN  A 101 (-1.9A)
ZN  A 101 (-3.3A)
 0.80A 2iwkB-2lxwA:
undetectable		 2iwkB-2lxwA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzu LIM
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00412
(LIM) 		3 CYH A  43
CYH A  67
HIS A  64
 ZN  A 201 (-2.2A)
ZN  A 201 (-2.2A)
ZN  A 201 (-3.0A)
 0.60A 2iwkB-2lzuA:
undetectable		 2iwkB-2lzuA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1s RING FINGER PROTEIN
Z

(Lassa
mammarenavirus) 		PF03854
(zf-P11) 		3 CYH A  64
CYH A  44
HIS A  47
 ZN  A 101 (-2.3A)
ZN  A 101 (-2.3A)
ZN  A 101 (-3.1A)
 0.85A 2iwkB-2m1sA:
undetectable		 2iwkB-2m1sA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n94 BOX C/D SNORNA
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04438
(zf-HIT) 		3 CYH A  39
CYH A  20
HIS A  33
 ZN  A 102 (-2.3A)
ZN  A 102 (-2.3A)
ZN  A 102 (-2.9A)
 0.88A 2iwkB-2n94A:
undetectable		 2iwkB-2n94A:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Mus musculus) 		no annotation 3 CYH A   9
CYH A  34
HIS A  31
 ZN  A 101 (-2.3A)
ZN  A 101 (-2.3A)
ZN  A 101 (-3.0A)
 0.70A 2iwkB-2naaA:
undetectable		 2iwkB-2naaA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odd PROTEIN CBFA2T1

(Homo sapiens) 		PF01753
(zf-MYND) 		3 CYH A 674
CYH A 699
HIS A 695
 ZN  A   2 (-2.3A)
ZN  A   2 (-2.3A)
ZN  A   2 (-3.2A)
 0.88A 2iwkB-2oddA:
undetectable		 2iwkB-2oddA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhk CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 4

(Homo sapiens) 		PF00642
(zf-CCCH) 		3 CYH C  76
CYH C  82
HIS C  86
 ZN  C 501 (-2.3A)
ZN  C 501 (-2.4A)
ZN  C 501 (-3.4A)
 0.81A 2iwkB-2rhkC:
undetectable		 2iwkB-2rhkC:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmn TUMOR PROTEIN 63

(Homo sapiens) 		PF00870
(P53) 		3 CYH A 273
CYH A 269
HIS A 208
 ZN  A   1 (-2.2A)
ZN  A   1 (-2.1A)
ZN  A   1 (-3.3A)
 0.70A 2iwkB-2rmnA:
undetectable		 2iwkB-2rmnA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl6 MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 CYH A 171
CYH A 149
HIS A 144
 ZN  A1266 (-2.0A)
ZN  A1266 (-2.2A)
ZN  A1266 (-3.1A)
 0.74A 2iwkB-2vl6A:
undetectable		 2iwkB-2vl6A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy5 U11/U12 SMALL
NUCLEAR
RIBONUCLEOPROTEIN 48
KDA PROTEIN

(Homo sapiens) 		PF05253
(zf-U11-48K) 		3 CYH A  78
CYH A  58
HIS A  64
 ZN  A1088 (-2.3A)
ZN  A1088 (-2.3A)
ZN  A1088 (-2.9A)
 0.85A 2iwkB-2vy5A:
undetectable		 2iwkB-2vy5A:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		3 CYH B 197
CYH B 201
HIS B 205
 CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-3.1A)
 0.16A 2iwkB-2yevB:
8.4		 2iwkB-2yevB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2n MUSCLEBLIND-LIKE
PROTEIN 1

(Homo sapiens) 		no annotation 3 CYH A  61
CYH A  66
HIS A  70
 ZN  A 102 (-2.3A)
ZN  A 102 (-2.3A)
ZN  A 102 (-3.3A)
 0.82A 2iwkB-3d2nA:
undetectable		 2iwkB-3d2nA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY

(Bacillus
anthracis) 		PF02567
(PhzC-PhzF) 		3 CYH A 175
CYH A 201
HIS A 212
 None
 0.77A 2iwkB-3ednA:
undetectable		 2iwkB-3ednA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF00480
(ROK) 		3 CYH A 581
CYH A 586
HIS A 569
 ZN  A 801 (-2.3A)
ZN  A 801 (-2.2A)
ZN  A 801 (-3.1A)
 0.74A 2iwkB-3eo3A:
undetectable		 2iwkB-3eo3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esr D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF13242
(Hydrolase_like) 		3 CYH A 112
CYH A 127
HIS A 114
 ZN  A 212 (-2.2A)
ZN  A 212 (-2.4A)
ZN  A 212 (-3.4A)
 0.86A 2iwkB-3esrA:
undetectable		 2iwkB-3esrA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdi UNCHARACTERIZED
PROTEIN

(Eubacterium
ventriosum) 		PF13189
(Cytidylate_kin2) 		3 CYH A 161
CYH A 104
HIS A 157
 None
 0.72A 2iwkB-3fdiA:
undetectable		 2iwkB-3fdiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF13242
(Hydrolase_like) 		3 CYH A  92
CYH A 107
HIS A  94
 ZN  A 801 (-2.2A)
ZN  A 801 (-2.3A)
ZN  A 801 (-3.2A)
 0.87A 2iwkB-3l8eA:
undetectable		 2iwkB-3l8eA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om3 CYTOCHROME C OXIDASE
SUBUNIT 2

(Rhodobacter
sphaeroides) 		PF00116
(COX2)
PF02790
(COX2_TM) 		3 CYH B 252
CYH B 256
HIS B 260
 CU1  B 288 ( 2.2A)
CU1  B 287 ( 2.3A)
CU1  B 287 (-3.0A)
 0.24A 2iwkB-3om3B:
9.5		 2iwkB-3om3B:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsv MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4

(Mus musculus) 		PF03165
(MH1) 		3 CYH A  71
CYH A 115
HIS A 132
 ZN  A   1 (-2.2A)
ZN  A   1 (-2.1A)
ZN  A   1 (-3.3A)
 0.79A 2iwkB-3qsvA:
undetectable		 2iwkB-3qsvA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s38 CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00116
(COX2)
PF09125
(COX2-transmemb) 		3 CYH B 149
CYH B 153
HIS B 157
 CUA  B 802 (-1.9A)
CUA  B 802 (-2.0A)
CUA  B 802 (-2.7A)
 0.41A 2iwkB-3s38B:
13.9		 2iwkB-3s38B:
14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 3 CYH A 618
CYH A 622
HIS A 626
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.3A)
CUA  A 701 (-3.0A)
 0.12A 2iwkB-3sbqA:
64.2		 2iwkB-3sbqA:
56.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp2 PRE-MRNA-SPLICING
FACTOR CWC2

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1)
PF16131
(Torus) 		3 CYH A  81
CYH A  87
HIS A  91
 ZN  A 229 (-2.2A)
ZN  A 229 (-2.3A)
ZN  A 229 (-3.3A)
 0.84A 2iwkB-3tp2A:
undetectable		 2iwkB-3tp2A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Rattus
norvegicus) 		no annotation 3 CYH A  82
CYH A  73
HIS A  86
 ZN  A 226 (-2.3A)
ZN  A 226 (-2.3A)
ZN  A 226 (-3.1A)
 0.86A 2iwkB-3u9gA:
undetectable		 2iwkB-3u9gA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Rattus
norvegicus) 		no annotation 3 CYH A  96
CYH A 106
HIS A 110
 ZN  A 227 (-2.3A)
ZN  A 227 (-2.4A)
ZN  A 227 (-3.1A)
 0.76A 2iwkB-3u9gA:
undetectable		 2iwkB-3u9gA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Rattus
norvegicus) 		no annotation 3 CYH A 182
CYH A 187
HIS A 191
 ZN  A 229 (-2.3A)
ZN  A 229 (-2.3A)
ZN  A 229 (-3.3A)
 0.88A 2iwkB-3u9gA:
undetectable		 2iwkB-3u9gA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		3 CYH A 169
CYH A 174
HIS A 157
 ZN  A 322 (-2.2A)
ZN  A 322 (-2.2A)
ZN  A 322 ( 3.2A)
 0.76A 2iwkB-3vglA:
undetectable		 2iwkB-3vglA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		3 CYH A 171
CYH A 176
HIS A 159
 ZN  A 401 (-2.3A)
ZN  A 401 (-2.3A)
ZN  A 401 (-3.1A)
 0.79A 2iwkB-3vovA:
undetectable		 2iwkB-3vovA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpb ALPHA-AMINOADIPATE
CARRIER PROTEIN LYSW

(Sulfurisphaera
tokodaii) 		no annotation 3 CYH E   6
CYH E  29
HIS E  27
 ZN  E 100 (-2.2A)
ZN  E 100 (-2.3A)
ZN  E 100 (-3.2A)
 0.68A 2iwkB-3vpbE:
undetectable		 2iwkB-3vpbE:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj2 NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
NAB2

(Saccharomyces
cerevisiae) 		PF14608
(zf-CCCH_2) 		3 CYH A 351
CYH A 340
HIS A 355
 ZN  A 501 (-2.4A)
ZN  A 501 (-2.4A)
ZN  A 501 (-3.6A)
 0.83A 2iwkB-3zj2A:
undetectable		 2iwkB-3zj2A:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj2 NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
NAB2

(Saccharomyces
cerevisiae) 		PF14608
(zf-CCCH_2) 		3 CYH A 382
CYH A 371
HIS A 386
 ZN  A 502 (-2.4A)
ZN  A 502 (-2.4A)
ZN  A 502 (-3.6A)
 0.87A 2iwkB-3zj2A:
undetectable		 2iwkB-3zj2A:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3e MATRIX M2-1

(Human
orthopneumovirus) 		PF06436
(Pneumovirus_M2) 		3 CYH A  21
CYH A   7
HIS A  25
 ZN  A 201 (-2.3A)
ZN  A 201 (-2.3A)
ZN  A 201 (-3.2A)
 0.83A 2iwkB-4c3eA:
undetectable		 2iwkB-4c3eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs8 M2-1

(Human
metapneumovirus) 		PF00642
(zf-CCCH)
PF06436
(Pneumovirus_M2) 		3 CYH A  21
CYH A   7
HIS A  25
 ZN  A1171 (-2.2A)
ZN  A1171 (-2.3A)
ZN  A1171 (-3.2A)
 0.86A 2iwkB-4cs8A:
undetectable		 2iwkB-4cs8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		3 CYH A 179
CYH A 184
HIS A 157
 ZN  A 401 (-2.3A)
ZN  A 401 (-2.2A)
ZN  A 401 (-3.2A)
 0.81A 2iwkB-4db3A:
undetectable		 2iwkB-4db3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4w DNA MISMATCH REPAIR
PROTEIN MLH1
DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF16413
(Mlh1_C)
PF08676
(MutL_C) 		3 CYH B 817
CYH A 769
HIS B 850
 ZN  B 901 (-2.4A)
ZN  B 902 ( 2.2A)
ZN  B 902 (-3.1A)
 0.73A 2iwkB-4e4wB:
2.6		 2iwkB-4e4wB:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		3 CYH A  66
CYH A  49
HIS A  72
 ZN  A 301 (-2.2A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.76A 2iwkB-4ggjA:
undetectable		 2iwkB-4ggjA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		3 CYH A  68
CYH A  49
HIS A  72
 ZN  A 301 (-2.1A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.85A 2iwkB-4ggjA:
undetectable		 2iwkB-4ggjA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii1 ZINC FINGER
CCCH-TYPE WITH G
PATCH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00642
(zf-CCCH) 		3 CYH A 188
CYH A 194
HIS A 198
 ZN  A 901 (-2.4A)
ZN  A 901 (-2.2A)
ZN  A 901 (-3.2A)
 0.80A 2iwkB-4ii1A:
undetectable		 2iwkB-4ii1A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lj0 NAB2

(Chaetomium
thermophilum) 		PF14608
(zf-CCCH_2) 		3 CYH A 437
CYH A 426
HIS A 441
 ZN  A 502 (-2.2A)
A  E   2 (-2.1A)
ZN  A 502 (-3.2A)
 0.77A 2iwkB-4lj0A:
undetectable		 2iwkB-4lj0A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lj0 NAB2

(Chaetomium
thermophilum) 		PF14608
(zf-CCCH_2) 		3 CYH A 456
CYH A 446
HIS A 460
 ZN  A 503 (-2.2A)
ZN  A 503 (-2.3A)
ZN  A 503 (-3.1A)
 0.79A 2iwkB-4lj0A:
undetectable		 2iwkB-4lj0A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 CYH A 171
CYH A 149
HIS A 144
 ZN  A2003 (-2.1A)
ZN  A2003 (-2.2A)
ZN  A2003 (-3.1A)
 0.72A 2iwkB-4r7yA:
undetectable		 2iwkB-4r7yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvo PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
thetaiotaomicron) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		3 CYH A 313
CYH A 251
HIS A 258
 ZN  A 501 (-2.4A)
ZN  A 501 (-2.3A)
ZN  A 501 (-3.2A)
 0.88A 2iwkB-4rvoA:
undetectable		 2iwkB-4rvoA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus musculus;
Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
PF12114
(Period_C) 		3 CYH A 432
CYH B1213
HIS A 491
 ZN  A2000 (-2.7A)
ZN  A2000 (-4.2A)
ZN  A2000 (-3.3A)
 0.75A 2iwkB-4u8hA:
undetectable		 2iwkB-4u8hA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9z CYTOCHROME C OXIDASE
SUBUNIT 2

(Bradyrhizobium
diazoefficiens) 		PF00116
(COX2) 		3 CYH A 229
CYH A 233
HIS A 237
 CU  A 302 ( 2.3A)
CU  A 302 ( 2.2A)
CU  A 302 (-3.1A)
 0.16A 2iwkB-4w9zA:
11.1		 2iwkB-4w9zA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh8 SPLICING FACTOR U2AF
23 KDA SUBUNIT

(Schizosaccharomyces
pombe) 		PF00076
(RRM_1)
PF00642
(zf-CCCH) 		3 CYH A 157
CYH A 163
HIS A 167
 ZN  A 302 (-2.3A)
ZN  A 302 (-2.3A)
ZN  A 302 (-3.3A)
 0.87A 2iwkB-4yh8A:
undetectable		 2iwkB-4yh8A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes) 		no annotation 3 CYH A 180
CYH A 149
HIS A 150
 ZN  A1293 (-2.0A)
ZN  A1293 (-2.3A)
None
 0.74A 2iwkB-5a3cA:
undetectable		 2iwkB-5a3cA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqk ICP27

(Human
alphaherpesvirus
1) 		PF05459
(Herpes_UL69) 		3 CYH A 400
CYH A 483
HIS A 479
 ZN  A 601 (-2.1A)
ZN  A 601 (-2.3A)
ZN  A 601 (-3.2A)
 0.80A 2iwkB-5bqkA:
undetectable		 2iwkB-5bqkA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		3 CYH A1273
CYH A1193
HIS A1380
 ZN  A2005 (-2.3A)
ZN  A2005 (-2.4A)
ZN  A2005 (-3.2A)
 0.83A 2iwkB-5deuA:
undetectable		 2iwkB-5deuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 CYH A 426
CYH A 471
HIS A 470
 None
 0.85A 2iwkB-5e7qA:
undetectable		 2iwkB-5e7qA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elh RING FINGER PROTEIN
UNKEMPT HOMOLOG

(Mus musculus) 		no annotation 3 CYH A  53
CYH A  61
HIS A  65
 ZN  A 201 (-2.3A)
ZN  A 201 (-2.3A)
ZN  A 201 (-3.2A)
 0.87A 2iwkB-5elhA:
undetectable		 2iwkB-5elhA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elk RING FINGER PROTEIN
UNKEMPT HOMOLOG

(Mus musculus) 		PF00642
(zf-CCCH) 		3 CYH A 234
CYH A 221
HIS A 238
 ZN  A 401 (-2.3A)
ZN  A 401 (-2.2A)
ZN  A 401 (-3.1A)
 0.86A 2iwkB-5elkA:
undetectable		 2iwkB-5elkA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elk RING FINGER PROTEIN
UNKEMPT HOMOLOG

(Mus musculus) 		PF00642
(zf-CCCH) 		3 CYH A 272
CYH A 278
HIS A 282
 ZN  A 402 (-2.4A)
ZN  A 402 (-2.2A)
ZN  A 402 (-3.2A)
 0.87A 2iwkB-5elkA:
undetectable		 2iwkB-5elkA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7r LMO0178 PROTEIN

(Listeria
monocytogenes) 		no annotation 3 CYH E 256
CYH E 261
HIS E 244
 ZN  E 503 (-2.2A)
ZN  E 503 (-2.3A)
ZN  E 503 ( 3.1A)
 0.84A 2iwkB-5f7rE:
undetectable		 2iwkB-5f7rE:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX

(Homo sapiens) 		no annotation 3 CYH D  95
CYH D 118
HIS D 113
 ZN  D 204 (-2.3A)
ZN  D 204 (-2.3A)
ZN  D 204 (-3.2A)
 0.82A 2iwkB-5h7sD:
undetectable		 2iwkB-5h7sD:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2l NAB2P

(Saccharomyces
cerevisiae) 		PF14608
(zf-CCCH_2) 		3 CYH A 426
CYH A 415
HIS A 430
 ZN  A 501 (-2.3A)
ZN  A 501 (-2.3A)
ZN  A 501 (-3.3A)
 0.80A 2iwkB-5l2lA:
undetectable		 2iwkB-5l2lA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2l NAB2P

(Saccharomyces
cerevisiae) 		PF14608
(zf-CCCH_2) 		3 CYH A 448
CYH A 437
HIS A 452
 ZN  A 502 (-2.3A)
ZN  A 502 (-2.4A)
ZN  A 502 (-3.3A)
 0.79A 2iwkB-5l2lA:
undetectable		 2iwkB-5l2lA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2l NAB2P

(Saccharomyces
cerevisiae) 		PF14608
(zf-CCCH_2) 		3 CYH A 469
CYH A 458
HIS A 473
 ZN  A 503 (-2.3A)
ZN  A 503 (-2.3A)
ZN  A 503 (-3.3A)
 0.78A 2iwkB-5l2lA:
undetectable		 2iwkB-5l2lA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nm9 MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG

(Trichoplax
adhaerens) 		no annotation 3 CYH A  65
CYH A 109
HIS A 126
 ZN  A 201 (-2.1A)
ZN  A 201 (-2.3A)
ZN  A 201 (-3.2A)
 0.78A 2iwkB-5nm9A:
undetectable		 2iwkB-5nm9A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 CYH A 281
CYH A 297
HIS A 283
 ZN  A 603 (-2.2A)
ZN  A 603 (-2.2A)
None
 0.85A 2iwkB-5udhA:
undetectable		 2iwkB-5udhA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuq ANTI-SIGMA-W FACTOR
RSIW

(Bacillus
subtilis) 		PF13490
(zf-HC2) 		3 CYH C   3
CYH C  37
HIS C  30
 ZN  C 301 (-2.3A)
ZN  C 301 (-2.3A)
ZN  C 301 (-3.7A)
 0.65A 2iwkB-5wuqC:
undetectable		 2iwkB-5wuqC:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5

(Mus musculus) 		no annotation 3 CYH B  65
CYH B 110
HIS B 127
 ZN  B 201 (-3.0A)
ZN  B 201 (-2.1A)
ZN  B 201 (-3.0A)
 0.57A 2iwkB-5x6mB:
undetectable		 2iwkB-5x6mB:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 CYH C1135
CYH C1176
HIS C1175
 None
 0.80A 2iwkB-5y3rC:
undetectable		 2iwkB-5y3rC:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 3 CYH A 333
CYH A 427
HIS A 423
 ZN  A 500 (-2.3A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.3A)
 0.83A 2iwkB-5zb3A:
undetectable		 2iwkB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj MRNA
3'-END-PROCESSING
PROTEIN YTH1

(Saccharomyces
cerevisiae) 		no annotation 3 CYH B  46
CYH B  52
HIS B  56
 ZN  B 302 ( 2.3A)
ZN  B 302 ( 2.3A)
ZN  B 302 ( 3.2A)
 0.86A 2iwkB-6eojB:
undetectable		 2iwkB-6eojB:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj MRNA
3'-END-PROCESSING
PROTEIN YTH1

(Saccharomyces
cerevisiae) 		no annotation 3 CYH B  75
CYH B  81
HIS B  85
 ZN  B 301 ( 2.3A)
ZN  B 301 ( 2.3A)
ZN  B 301 ( 3.2A)
 0.85A 2iwkB-6eojB:
undetectable		 2iwkB-6eojB:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuw CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 4

(Homo sapiens) 		no annotation 3 CYH C  82
CYH C  68
HIS C  86
 ZN  C 202 (-2.2A)
ZN  C 202 (-2.3A)
ZN  C 202 (-3.3A)
 0.85A 2iwkB-6fuwC:
undetectable		 2iwkB-6fuwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuw CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 4

(Homo sapiens) 		no annotation 3 CYH C 110
CYH C  96
HIS C 114
 ZN  C 203 (-2.4A)
ZN  C 203 (-2.2A)
ZN  C 203 (-3.1A)
 0.86A 2iwkB-6fuwC:
undetectable		 2iwkB-6fuwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9atc ASPARTATE
TRANSCARBAMOYLASE

(Escherichia
coli) 		PF01948
(PyrI)
PF02748
(PyrI_C) 		3 CYH B 109
CYH B 114
HIS B 117
 ZN  B   1 (-2.3A)
ZN  B   1 (-2.2A)
None
 0.70A 2iwkB-9atcB:
undetectable		 2iwkB-9atcB:
12.91