SIMILAR PATTERNS OF AMINO ACIDS FOR 2IVU_A_ZD6A3015_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bu8 | PROTEIN (PANCREATICLIPASE RELATEDPROTEIN 2) (Rattusnorvegicus) |
PF00151(Lipase)PF01477(PLAT) | 3 | ALA A 155GLY A 216SER A 266 | None | 0.52A | 2ivuA-1bu8A:0.0 | 2ivuA-1bu8A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4k | PROTEIN (ORNITHINEDECARBOXYLASE) (Lactobacillussp. 30A) |
PF01276(OKR_DC_1)PF03709(OKR_DC_1_N)PF03711(OKR_DC_1_C) | 3 | ALA A 318GLY A 197SER A 225 | PLP A 955 (-3.4A)PLP A 955 (-3.4A)PLP A 955 ( 3.9A) | 0.59A | 2ivuA-1c4kA:0.0 | 2ivuA-1c4kA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpc | C-PHYCOCYANIN (ALPHASUBUNIT)C-PHYCOCYANIN (BETA SUBUNIT) (Microchaetediplosiphon;Microchaetediplosiphon) |
PF00502(Phycobilisome)PF00502(Phycobilisome) | 3 | ALA A 41GLY B 21SER B 28 | None | 0.59A | 2ivuA-1cpcA:undetectable | 2ivuA-1cpcA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efp | PROTEIN (ELECTRONTRANSFERFLAVOPROTEIN) (Paracoccusdenitrificans) |
PF00766(ETF_alpha)PF01012(ETF) | 3 | ALA A 193GLY A 224SER A 185 | None | 0.46A | 2ivuA-1efpA:0.0 | 2ivuA-1efpA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ez4 | LACTATEDEHYDROGENASE (Lactobacilluspentosus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | ALA A 136GLY A 252SER A 259 | NAD A1352 (-4.2A)NoneNone | 0.56A | 2ivuA-1ez4A:0.0 | 2ivuA-1ez4A:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fcd | FLAVOCYTOCHROME CSULFIDEDEHYDROGENASE(FLAVIN-BINDINGSUBUNIT) (Allochromatiumvinosum) |
PF07992(Pyr_redox_2)PF09242(FCSD-flav_bind) | 3 | ALA A 315GLY A 13SER A 296 | NoneFAD A 699 (-3.4A)None | 0.59A | 2ivuA-1fcdA:undetectable | 2ivuA-1fcdA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ft5 | CYTOCHROME C554 (Nitrosomonaseuropaea) |
PF13435(Cytochrome_C554) | 3 | ALA A 30GLY A 62SER A 90 | HEM A 216 (-3.9A)NoneHEM A 216 (-3.9A) | 0.53A | 2ivuA-1ft5A:undetectable | 2ivuA-1ft5A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8w | LEUCOAGGLUTINATINGPHYTOHEMAGGLUTININ (Phaseolusvulgaris) |
PF00139(Lectin_legB) | 3 | ALA A 91GLY A 107SER A 97 | None | 0.59A | 2ivuA-1g8wA:0.0 | 2ivuA-1g8wA:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gcb | GAL6 HG (EMTS)DERIVATIVE (Saccharomycescerevisiae) |
PF03051(Peptidase_C1_2) | 3 | ALA A 261GLY A 156SER A 251 | None | 0.58A | 2ivuA-1gcbA:0.0 | 2ivuA-1gcbA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpl | RP2 LIPASE (Cavia porcellus) |
PF00151(Lipase)PF01477(PLAT) | 3 | ALA A 155GLY A 216SER A 266 | None | 0.45A | 2ivuA-1gplA:0.3 | 2ivuA-1gplA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz5 | ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF00982(Glyco_transf_20) | 3 | ALA A 275GLY A 268SER A 259 | None | 0.59A | 2ivuA-1gz5A:0.0 | 2ivuA-1gz5A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hqs | ISOCITRATEDEHYDROGENASE (Bacillussubtilis) |
PF00180(Iso_dh) | 3 | ALA A 44GLY A 415SER A 385 | None | 0.57A | 2ivuA-1hqsA:undetectable | 2ivuA-1hqsA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ig8 | HEXOKINASE PII (Saccharomycescerevisiae) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 3 | ALA A 416GLY A 233SER A 396 | NoneSO4 A 501 ( 3.7A)None | 0.59A | 2ivuA-1ig8A:undetectable | 2ivuA-1ig8A:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lpb | LIPASE (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 3 | ALA B 155GLY B 216SER B 266 | None | 0.44A | 2ivuA-1lpbB:undetectable | 2ivuA-1lpbB:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m64 | FLAVOCYTOCHROME C3 (Shewanellafrigidimarina) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 3 | ALA A 165GLY A 533SER A 140 | FAD A3000 (-3.3A)FAD A3000 (-3.4A)None | 0.55A | 2ivuA-1m64A:undetectable | 2ivuA-1m64A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n5x | XANTHINEDEHYDROGENASE (Bos taurus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 3 | ALA A 590GLY A 795SER A 111 | NoneNoneFES A3001 ( 4.9A) | 0.59A | 2ivuA-1n5xA:undetectable | 2ivuA-1n5xA:12.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1na6 | RESTRICTIONENDONUCLEASE ECORII (Escherichiacoli) |
PF09019(EcoRII-C)PF09217(EcoRII-N) | 3 | ALA A 80GLY A 39SER A 106 | None | 0.58A | 2ivuA-1na6A:undetectable | 2ivuA-1na6A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oa1 | HYDROXYLAMINEREDUCTASE (Desulfovibriovulgaris) |
PF03063(Prismane) | 3 | ALA A 97GLY A 45SER A 57 | None | 0.59A | 2ivuA-1oa1A:undetectable | 2ivuA-1oa1A:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p0z | SENSOR KINASE CITA (Klebsiellapneumoniae) |
PF17203(sCache_3_2) | 3 | ALA A 87GLY A 108SER A 24 | NoneNone NA A1633 (-2.4A) | 0.60A | 2ivuA-1p0zA:undetectable | 2ivuA-1p0zA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pvd | PYRUVATEDECARBOXYLASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 3 | ALA A 392GLY A 413SER A 446 | NoneNoneTPP A 557 ( 2.4A) | 0.38A | 2ivuA-1pvdA:undetectable | 2ivuA-1pvdA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q15 | CARA (Pectobacteriumcarotovorum) |
PF00733(Asn_synthase)PF09147(DUF1933) | 3 | ALA A 428GLY A 248SER A 347 | None | 0.56A | 2ivuA-1q15A:undetectable | 2ivuA-1q15A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1r | PUTIDAREDOXINREDUCTASE (Pseudomonasputida) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 3 | ALA A 181GLY A 158SER A 194 | None | 0.59A | 2ivuA-1q1rA:undetectable | 2ivuA-1q1rA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qge | PROTEIN(TRIACYLGLYCEROLHYDROLASE) (Burkholderiaglumae) |
no annotation | 3 | ALA E 226GLY E 264SER E 259 | None | 0.57A | 2ivuA-1qgeE:undetectable | 2ivuA-1qgeE:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rp1 | PANCREATIC LIPASERELATED PROTEIN 1 (Canis lupus) |
PF00151(Lipase)PF01477(PLAT) | 3 | ALA A 155GLY A 216SER A 266 | None | 0.60A | 2ivuA-1rp1A:undetectable | 2ivuA-1rp1A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s1f | PUTATIVE CYTOCHROMEP450 (Streptomycescoelicolor) |
PF00067(p450) | 3 | ALA A 245GLY A 356SER A 363 | PIM A 431 (-3.6A)NoneNone | 0.56A | 2ivuA-1s1fA:undetectable | 2ivuA-1s1fA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb3 | 4-HYDROXYBENZOYL-COAREDUCTASE ALPHASUBUNIT (Thaueraaromatica) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | ALA A 509GLY A 519SER A 485 | None | 0.53A | 2ivuA-1sb3A:undetectable | 2ivuA-1sb3A:17.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1snx | TYROSINE-PROTEINKINASE ITK/TSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ALA A 389GLY A 441SER A 499 | None | 0.46A | 2ivuA-1snxA:22.5 | 2ivuA-1snxA:33.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tmo | TRIMETHYLAMINEN-OXIDE REDUCTASE (Shewanellamassilia) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | ALA A 745GLY A 79SER A 788 | None | 0.58A | 2ivuA-1tmoA:undetectable | 2ivuA-1tmoA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 2 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 3 | ALA B 45GLY B 224SER B 202 | None | 0.59A | 2ivuA-1tqyB:undetectable | 2ivuA-1tqyB:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2l | PEROXIDASE/CATALASEHPI (Escherichiacoli) |
PF00141(peroxidase) | 3 | ALA A 505GLY A 620SER A 463 | None | 0.59A | 2ivuA-1u2lA:undetectable | 2ivuA-1u2lA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uzj | FIBRILLIN-1 (Homo sapiens) |
PF00683(TB)PF07645(EGF_CA) | 3 | ALA A1560GLY A1591SER A1499 | None | 0.53A | 2ivuA-1uzjA:undetectable | 2ivuA-1uzjA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v71 | HYPOTHETICAL PROTEINC320.14 INCHROMOSOME III (Schizosaccharomycespombe) |
PF00291(PALP) | 3 | ALA A 24GLY A 160SER A 66 | None | 0.60A | 2ivuA-1v71A:undetectable | 2ivuA-1v71A:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v71 | HYPOTHETICAL PROTEINC320.14 INCHROMOSOME III (Schizosaccharomycespombe) |
PF00291(PALP) | 3 | ALA A 234GLY A 183SER A 308 | NonePLP A 350 (-3.3A)PLP A 350 (-2.8A) | 0.60A | 2ivuA-1v71A:undetectable | 2ivuA-1v71A:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdw | TRYPTOPHAN SYNTHASEBETA CHAIN 1 (Pyrococcusfuriosus) |
PF00291(PALP) | 3 | ALA B 296GLY B 227SER B 371 | NonePLP B 400 (-3.5A)PLP B 400 (-2.6A) | 0.51A | 2ivuA-1wdwB:undetectable | 2ivuA-1wdwB:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xvi | PUTATIVEMANNOSYL-3-PHOSPHOGLYCERATE PHOSPHATASE (Escherichiacoli) |
PF08282(Hydrolase_3) | 3 | ALA A 176GLY A 16SER A 47 | SO4 A 501 (-3.7A)NoneNone | 0.57A | 2ivuA-1xviA:undetectable | 2ivuA-1xviA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ydw | AX110P-LIKE PROTEIN (Arabidopsisthaliana) |
PF01408(GFO_IDH_MocA) | 3 | ALA A 44GLY A 35SER A 65 | None | 0.60A | 2ivuA-1ydwA:undetectable | 2ivuA-1ydwA:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yhu | HEMOGLOBIN B1A CHAIN (Riftiapachyptila) |
PF00042(Globin) | 3 | ALA C 114GLY C 139SER C 145 | None | 0.58A | 2ivuA-1yhuC:undetectable | 2ivuA-1yhuC:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yjg | SURFACE PROTEIN VSPA (Borreliaturicatae) |
PF01441(Lipoprotein_6) | 3 | ALA A 104GLY A 97SER A 67 | None | 0.50A | 2ivuA-1yjgA:3.5 | 2ivuA-1yjgA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ym0 | FIBRINOTIC ENZYMECOMPONENT BFIBRINOTIC ENZYMECOMPONENT B (Eisenia fetida;Eisenia fetida) |
PF00089(Trypsin)no annotation | 3 | ALA B 9GLY B 2SER A 200 | None | 0.54A | 2ivuA-1ym0B:undetectable | 2ivuA-1ym0B:6.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yob | FLAVODOXIN 2 (Azotobactervinelandii) |
PF00258(Flavodoxin_1) | 3 | ALA A 109GLY A 53SER A 73 | None | 0.52A | 2ivuA-1yobA:undetectable | 2ivuA-1yobA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3z | DIALKYLGLYCINEDECARBOXYLASE (Burkholderiacepacia) |
PF00202(Aminotran_3) | 3 | ALA A 245GLY A 140SER A 215 | PLP A 434 (-3.6A)PLP A 434 ( 3.9A)MES A 435 (-3.2A) | 0.56A | 2ivuA-1z3zA:undetectable | 2ivuA-1z3zA:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bcm | F1845 FIMBRIALPROTEIN (Escherichiacoli) |
no annotation | 3 | ALA B 56GLY B 109SER B 91 | None | 0.50A | 2ivuA-2bcmB:undetectable | 2ivuA-2bcmB:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eij | CYTOCHROME C OXIDASESUBUNIT 1 (Bos taurus) |
PF00115(COX1) | 3 | ALA A 276GLY A 269SER A 255 | None | 0.58A | 2ivuA-2eijA:undetectable | 2ivuA-2eijA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fav | REPLICASEPOLYPROTEIN 1AB(PP1AB) (ORF1AB) (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF01661(Macro) | 3 | ALA A 39GLY A 131SER A 140 | None | 0.42A | 2ivuA-2favA:undetectable | 2ivuA-2favA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fr1 | ERYTHROMYCINSYNTHASE, ERYAI (Saccharopolysporaerythraea) |
PF08659(KR) | 3 | ALA A1591GLY A1766SER A1773 | None | 0.39A | 2ivuA-2fr1A:undetectable | 2ivuA-2fr1A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5c | PREPHENATEDEHYDROGENASE (Aquifexaeolicus) |
PF02153(PDH) | 3 | ALA A 150GLY A 195SER A 48 | None | 0.53A | 2ivuA-2g5cA:undetectable | 2ivuA-2g5cA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ga0 | SURFACE PROTEIN VSPA (Borreliaturicatae) |
PF01441(Lipoprotein_6) | 3 | ALA A 104GLY A 97SER A 67 | None | 0.49A | 2ivuA-2ga0A:3.4 | 2ivuA-2ga0A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gjn | HYPOTHETICAL PROTEINPA1024 (Pseudomonasaeruginosa) |
PF03060(NMO) | 3 | ALA A 103GLY A 151SER A 178 | FMN A1904 (-3.1A)NIS A 500 (-2.8A)FMN A1904 (-3.2A) | 0.38A | 2ivuA-2gjnA:undetectable | 2ivuA-2gjnA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h21 | RIBULOSE-1,5BISPHOSPHATECARBOXYLASE/OXYGENASE (Pisum sativum) |
PF00856(SET)PF09273(Rubis-subs-bind) | 3 | ALA A 297GLY A 435SER A 171 | None | 0.59A | 2ivuA-2h21A:undetectable | 2ivuA-2h21A:22.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hen | EPHRIN TYPE-BRECEPTOR 2 (Mus musculus) |
PF07714(Pkinase_Tyr) | 3 | ALA A 659GLY A 713SER A 771 | ADP A 400 (-3.2A)ADP A 400 ( 4.2A)ADP A 400 ( 4.8A) | 0.41A | 2ivuA-2henA:24.1 | 2ivuA-2henA:33.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iks | DNA-BINDINGTRANSCRIPTIONAL DUALREGULATOR (Escherichiacoli) |
PF00532(Peripla_BP_1) | 3 | ALA A 217GLY A 252SER A 246 | None | 0.50A | 2ivuA-2iksA:undetectable | 2ivuA-2iksA:24.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iqx | PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN1 (Rattusnorvegicus) |
PF01161(PBP) | 3 | ALA A 171GLY A 108SER A 176 | None | 0.38A | 2ivuA-2iqxA:undetectable | 2ivuA-2iqxA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ix8 | ELONGATION FACTOR 3A (Saccharomycescerevisiae) |
PF00005(ABC_tran) | 3 | ALA A1733GLY A1943SER A1863 | None | 0.59A | 2ivuA-2ix8A:undetectable | 2ivuA-2ix8A:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jis | CYSTEINE SULFINICACID DECARBOXYLASE (Homo sapiens) |
PF00282(Pyridoxal_deC) | 3 | ALA A 300GLY A 151SER A 193 | NonePLP A1494 (-3.5A)PLP A1494 ( 4.1A) | 0.59A | 2ivuA-2jisA:undetectable | 2ivuA-2jisA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o34 | HYPOTHETICAL PROTEIN (Desulfovibriovulgaris) |
no annotation | 3 | ALA A 199GLY A 129SER A 165 | NA A 501 ( 4.8A) NA A 503 ( 4.2A)None | 0.58A | 2ivuA-2o34A:undetectable | 2ivuA-2o34A:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppl | PANCREATICLIPASE-RELATEDPROTEIN 1 (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 3 | ALA A 174GLY A 234SER A 284 | None NA A 480 (-4.3A)None | 0.55A | 2ivuA-2pplA:undetectable | 2ivuA-2pplA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pvs | PANCREATICLIPASE-RELATEDPROTEIN 2 (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 3 | ALA A 155GLY A 216SER A 266 | None | 0.53A | 2ivuA-2pvsA:undetectable | 2ivuA-2pvsA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qks | KIR3.1-PROKARYOTICKIR CHANNEL CHIMERA (Mus musculus;Paraburkholderiaxenovorans) |
PF01007(IRK) | 3 | ALA A 259GLY A 163SER A 168 | None | 0.56A | 2ivuA-2qksA:undetectable | 2ivuA-2qksA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qob | EPHRIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ALA A 651GLY A 705SER A 763 | PTR A 701 ( 4.7A)NoneNone | 0.28A | 2ivuA-2qobA:33.4 | 2ivuA-2qobA:29.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r2p | EPHRIN TYPE-ARECEPTOR 5 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 3 | ALA A 705GLY A 759SER A 817 | None | 0.27A | 2ivuA-2r2pA:35.3 | 2ivuA-2r2pA:32.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rmp | MUCOROPEPSIN (Rhizomucormiehei) |
PF00026(Asp) | 3 | ALA A 87GLY A 131SER A 41 | None | 0.48A | 2ivuA-2rmpA:undetectable | 2ivuA-2rmpA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uvf | EXOPOLYGALACTURONASE (Yersiniaenterocolitica) |
PF00295(Glyco_hydro_28)PF12708(Pectate_lyase_3) | 3 | ALA A 513GLY A 410SER A 469 | None | 0.57A | 2ivuA-2uvfA:undetectable | 2ivuA-2uvfA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2var | FRUCTOKINASE (Sulfolobussolfataricus) |
PF00294(PfkB) | 3 | ALA A 54GLY A 34SER A 69 | NoneKDG A1313 ( 3.3A)None | 0.46A | 2ivuA-2varA:undetectable | 2ivuA-2varA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vk4 | PYRUVATEDECARBOXYLASE (Kluyveromyceslactis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 3 | ALA A 392GLY A 413SER A 446 | NoneTPP A 600 (-4.9A)TPP A 600 (-2.7A) | 0.34A | 2ivuA-2vk4A:undetectable | 2ivuA-2vk4A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vn7 | GLUCOAMYLASE (Trichodermareesei) |
PF00686(CBM_20)PF00723(Glyco_hydro_15) | 3 | ALA A 84GLY A 22SER A 55 | None | 0.55A | 2ivuA-2vn7A:undetectable | 2ivuA-2vn7A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vos | FOLYLPOLYGLUTAMATESYNTHASE PROTEINFOLC (Mycobacteriumtuberculosis) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 3 | ALA A 363GLY A 76SER A 200 | ADP A1490 (-3.5A)ADP A1490 (-3.1A)None | 0.55A | 2ivuA-2vosA:undetectable | 2ivuA-2vosA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vri | NON-STRUCTURALPROTEIN 3 (HumancoronavirusNL63) |
PF01661(Macro) | 3 | ALA A 31GLY A 121SER A 130 | None | 0.38A | 2ivuA-2vriA:undetectable | 2ivuA-2vriA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3w | DIHYDROFOLATEREDUCTASE (Mycobacteriumavium) |
PF00186(DHFR_1) | 3 | ALA A 134GLY A 103SER A 53 | NDP A1169 ( 3.8A)NDP A1169 ( 3.8A)NDP A1169 ( 3.9A) | 0.53A | 2ivuA-2w3wA:undetectable | 2ivuA-2w3wA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5o | ALPHA-L-ARABINOFURANOSIDASE (Fusariumgraminearum) |
no annotation | 3 | ALA A 287GLY A 246SER A 253 | None | 0.55A | 2ivuA-2w5oA:2.5 | 2ivuA-2w5oA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wc1 | FLAVODOXIN (Rhodobactercapsulatus) |
PF00258(Flavodoxin_1) | 3 | ALA A 110GLY A 54SER A 74 | None | 0.59A | 2ivuA-2wc1A:undetectable | 2ivuA-2wc1A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wf7 | BETA-PHOSPHOGLUCOMUTASE (Lactococcuslactis) |
PF13419(HAD_2) | 3 | ALA A 113GLY A 174SER A 181 | None | 0.49A | 2ivuA-2wf7A:undetectable | 2ivuA-2wf7A:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wwv | N,N'-DIACETYLCHITOBIOSE-SPECIFICPHOSPHOTRANSFERASEENZYME IIA COMPONENT (Escherichiacoli) |
PF02255(PTS_IIA) | 3 | ALA A 87GLY A 16SER A 44 | None | 0.59A | 2ivuA-2wwvA:undetectable | 2ivuA-2wwvA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xqr | INVERTASE INHIBITOR (Nicotianatabacum) |
PF04043(PMEI) | 3 | ALA B 88GLY B 139SER B 107 | None | 0.58A | 2ivuA-2xqrB:2.3 | 2ivuA-2xqrB:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xwg | SORTASE (Actinomycesoris) |
PF04203(Sortase) | 3 | ALA A 156GLY A 183SER A 199 | None | 0.59A | 2ivuA-2xwgA:undetectable | 2ivuA-2xwgA:19.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyu | EPHRIN TYPE-ARECEPTOR 4, (Mus musculus) |
PF07714(Pkinase_Tyr) | 3 | ALA A 651GLY A 705SER A 763 | Q9G A1898 (-3.2A)Q9G A1898 ( 3.8A)Q9G A1898 (-3.2A) | 0.16A | 2ivuA-2xyuA:27.4 | 2ivuA-2xyuA:34.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT B (Prochlorococcusmarinus) |
PF00148(Oxidored_nitro)PF08369(PCP_red) | 3 | ALA D 133GLY D 173SER D 22 | None | 0.56A | 2ivuA-2ynmD:undetectable | 2ivuA-2ynmD:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9x | SELENOCYSTEINE LYASE (Rattusnorvegicus) |
PF00266(Aminotran_5) | 3 | ALA A 223GLY A 86SER A 135 | PLP A 501 (-3.4A)PLP A 501 ( 4.8A)PLP A 501 ( 3.7A) | 0.58A | 2ivuA-3a9xA:undetectable | 2ivuA-3a9xA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abz | BETA-GLUCOSIDASE I (Kluyveromycesmarxianus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF07691(PA14)PF14310(Fn3-like) | 3 | ALA A 95GLY A 46SER A 61 | None | 0.56A | 2ivuA-3abzA:undetectable | 2ivuA-3abzA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3agr | NUCLEOSIDETRIPHOSPHATEHYDROLASE (Neosporacaninum) |
PF01150(GDA1_CD39) | 3 | ALA A 165GLY A 255SER A 299 | None | 0.51A | 2ivuA-3agrA:undetectable | 2ivuA-3agrA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3agr | NUCLEOSIDETRIPHOSPHATEHYDROLASE (Neosporacaninum) |
PF01150(GDA1_CD39) | 3 | ALA A 165GLY A 304SER A 299 | None | 0.60A | 2ivuA-3agrA:undetectable | 2ivuA-3agrA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqp | PROBABLE SECDFPROTEIN-EXPORTMEMBRANE PROTEIN (Thermusthermophilus) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 3 | ALA A 554GLY A 267SER A 692 | None | 0.50A | 2ivuA-3aqpA:2.0 | 2ivuA-3aqpA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b0h | NITRITE REDUCTASE (Nicotianatabacum) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 3 | ALA A 487GLY A 443SER A 458 | NoneSF4 A 602 ( 4.3A)None | 0.60A | 2ivuA-3b0hA:undetectable | 2ivuA-3b0hA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b0p | TRNA-DIHYDROURIDINESYNTHASE (Thermusthermophilus) |
PF01207(Dus) | 3 | ALA A 65GLY A 101SER A 95 | None | 0.54A | 2ivuA-3b0pA:3.9 | 2ivuA-3b0pA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bew | MAJORHISTOCOMPATIBILITYCOMPLEX CLASS IGLYCOPROTEINHAPLOTYPE B21 (Gallus gallus) |
PF00129(MHC_I)PF07654(C1-set) | 3 | ALA A 201GLY A 266SER A 261 | None | 0.60A | 2ivuA-3bewA:undetectable | 2ivuA-3bewA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cir | FUMARATE REDUCTASEIRON-SULFUR SUBUNIT (Escherichiacoli) |
PF13085(Fer2_3)PF13183(Fer4_8) | 3 | ALA B 115GLY B 169SER B 197 | None | 0.54A | 2ivuA-3cirB:undetectable | 2ivuA-3cirB:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egj | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Vibrio cholerae) |
PF01979(Amidohydro_1) | 3 | ALA A 271GLY A 64SER A 87 | None | 0.59A | 2ivuA-3egjA:undetectable | 2ivuA-3egjA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ejf | NON-STRUCTURALPROTEIN 3 (Aviancoronavirus) |
PF01661(Macro) | 3 | ALA A 38GLY A 130SER A 139 | None | 0.45A | 2ivuA-3ejfA:undetectable | 2ivuA-3ejfA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ejg | NON-STRUCTURALPROTEIN 3 (Humancoronavirus229E) |
PF01661(Macro) | 3 | ALA A 34GLY A 124SER A 133 | None | 0.57A | 2ivuA-3ejgA:undetectable | 2ivuA-3ejgA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg2 | PUTATIVE RUBREDOXINREDUCTASE (Rhodopseudomonaspalustris) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 3 | ALA P 174GLY P 151SER P 187 | None | 0.57A | 2ivuA-3fg2P:undetectable | 2ivuA-3fg2P:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyx | ADENYLYLSULFATEREDUCTASE (Desulfovibriogigas) |
PF00890(FAD_binding_2) | 3 | ALA A 178GLY A 35SER A 67 | NoneFAD A1000 (-3.3A)FAD A1000 (-2.9A) | 0.57A | 2ivuA-3gyxA:undetectable | 2ivuA-3gyxA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5t | TRANSCRIPTIONALREGULATOR, LACIFAMILY (Corynebacteriumglutamicum) |
PF00356(LacI)PF13377(Peripla_BP_3) | 3 | ALA A 228GLY A 193SER A 196 | None | 0.59A | 2ivuA-3h5tA:undetectable | 2ivuA-3h5tA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmj | FATTY ACID SYNTHASESUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00109(ketoacyl-synt)PF01648(ACPS)PF02801(Ketoacyl-synt_C) | 3 | ALA A1587GLY A1028SER A1218 | None | 0.50A | 2ivuA-3hmjA:undetectable | 2ivuA-3hmjA:11.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hqf | RESTRICTIONENDONUCLEASE (Escherichiacoli) |
PF09217(EcoRII-N) | 3 | ALA A 80GLY A 39SER A 106 | None | 0.60A | 2ivuA-3hqfA:undetectable | 2ivuA-3hqfA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE LARGEMOLYBDOPTERINSUBUNITNICOTINATEDEHYDROGENASE MEDIUMMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri;Eubacteriumbarkeri) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2)PF02738(Ald_Xan_dh_C2) | 3 | ALA A 308GLY B 247SER A 44 | None | 0.56A | 2ivuA-3hrdA:undetectable | 2ivuA-3hrdA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i0p | MALATE DEHYDROGENASE (Entamoebahistolytica) |
PF02615(Ldh_2) | 3 | ALA A 183GLY A 190SER A 150 | NAD A 401 (-3.3A)NoneNone | 0.55A | 2ivuA-3i0pA:undetectable | 2ivuA-3i0pA:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 1 (Thermusthermophilus) |
PF01512(Complex1_51K)PF10531(SLBB)PF10589(NADH_4Fe-4S) | 3 | ALA 1 406GLY 1 362SER 1 398 | NoneNoneSF4 1 439 ( 4.5A) | 0.58A | 2ivuA-3i9v1:undetectable | 2ivuA-3i9v1:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iau | THREONINE DEAMINASE (Solanumlycopersicum) |
PF00291(PALP) | 3 | ALA A 268GLY A 217SER A 344 | NoneLLP A 91 ( 3.4A)LLP A 91 ( 2.7A) | 0.54A | 2ivuA-3iauA:undetectable | 2ivuA-3iauA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwa | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE (Desulfovibriovulgaris) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | ALA A 191GLY A 197SER A 204 | None | 0.59A | 2ivuA-3iwaA:undetectable | 2ivuA-3iwaA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF10 (Schizosaccharomycespombe) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF16004(EFTUD2) | 3 | ALA B 501GLY B 620SER B 627 | None | 0.59A | 2ivuA-3jb9B:undetectable | 2ivuA-3jb9B:16.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 3 | ALA A 665GLY A 719SER A 777 | NoneGOL A 403 (-3.4A)None | 0.53A | 2ivuA-3kulA:35.6 | 2ivuA-3kulA:31.36 |