SIMILAR PATTERNS OF AMINO ACIDS FOR 2IVU_A_ZD6A3015_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)


(Rattus
norvegicus)
PF00151
(Lipase)
PF01477
(PLAT)
3 ALA A 155
GLY A 216
SER A 266
None
0.52A 2ivuA-1bu8A:
0.0
2ivuA-1bu8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)


(Lactobacillus
sp. 30A)
PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C)
3 ALA A 318
GLY A 197
SER A 225
PLP  A 955 (-3.4A)
PLP  A 955 (-3.4A)
PLP  A 955 ( 3.9A)
0.59A 2ivuA-1c4kA:
0.0
2ivuA-1c4kA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpc C-PHYCOCYANIN (ALPHA
SUBUNIT)
C-PHYCOCYANIN (BETA
SUBUNIT)


(Microchaete
diplosiphon;
Microchaete
diplosiphon)
PF00502
(Phycobilisome)
PF00502
(Phycobilisome)
3 ALA A  41
GLY B  21
SER B  28
None
0.59A 2ivuA-1cpcA:
undetectable
2ivuA-1cpcA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)


(Paracoccus
denitrificans)
PF00766
(ETF_alpha)
PF01012
(ETF)
3 ALA A 193
GLY A 224
SER A 185
None
0.46A 2ivuA-1efpA:
0.0
2ivuA-1efpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE


(Lactobacillus
pentosus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
3 ALA A 136
GLY A 252
SER A 259
NAD  A1352 (-4.2A)
None
None
0.56A 2ivuA-1ez4A:
0.0
2ivuA-1ez4A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)


(Allochromatium
vinosum)
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
3 ALA A 315
GLY A  13
SER A 296
None
FAD  A 699 (-3.4A)
None
0.59A 2ivuA-1fcdA:
undetectable
2ivuA-1fcdA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ft5 CYTOCHROME C554

(Nitrosomonas
europaea)
PF13435
(Cytochrome_C554)
3 ALA A  30
GLY A  62
SER A  90
HEM  A 216 (-3.9A)
None
HEM  A 216 (-3.9A)
0.53A 2ivuA-1ft5A:
undetectable
2ivuA-1ft5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ


(Phaseolus
vulgaris)
PF00139
(Lectin_legB)
3 ALA A  91
GLY A 107
SER A  97
None
0.59A 2ivuA-1g8wA:
0.0
2ivuA-1g8wA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE


(Saccharomyces
cerevisiae)
PF03051
(Peptidase_C1_2)
3 ALA A 261
GLY A 156
SER A 251
None
0.58A 2ivuA-1gcbA:
0.0
2ivuA-1gcbA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpl RP2 LIPASE

(Cavia porcellus)
PF00151
(Lipase)
PF01477
(PLAT)
3 ALA A 155
GLY A 216
SER A 266
None
0.45A 2ivuA-1gplA:
0.3
2ivuA-1gplA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE


(Escherichia
coli)
PF00982
(Glyco_transf_20)
3 ALA A 275
GLY A 268
SER A 259
None
0.59A 2ivuA-1gz5A:
0.0
2ivuA-1gz5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE


(Bacillus
subtilis)
PF00180
(Iso_dh)
3 ALA A  44
GLY A 415
SER A 385
None
0.57A 2ivuA-1hqsA:
undetectable
2ivuA-1hqsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
3 ALA A 416
GLY A 233
SER A 396
None
SO4  A 501 ( 3.7A)
None
0.59A 2ivuA-1ig8A:
undetectable
2ivuA-1ig8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens)
PF00151
(Lipase)
PF01477
(PLAT)
3 ALA B 155
GLY B 216
SER B 266
None
0.44A 2ivuA-1lpbB:
undetectable
2ivuA-1lpbB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina)
PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2)
3 ALA A 165
GLY A 533
SER A 140
FAD  A3000 (-3.3A)
FAD  A3000 (-3.4A)
None
0.55A 2ivuA-1m64A:
undetectable
2ivuA-1m64A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE


(Bos taurus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
3 ALA A 590
GLY A 795
SER A 111
None
None
FES  A3001 ( 4.9A)
0.59A 2ivuA-1n5xA:
undetectable
2ivuA-1n5xA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1na6 RESTRICTION
ENDONUCLEASE ECORII


(Escherichia
coli)
PF09019
(EcoRII-C)
PF09217
(EcoRII-N)
3 ALA A  80
GLY A  39
SER A 106
None
0.58A 2ivuA-1na6A:
undetectable
2ivuA-1na6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE


(Desulfovibrio
vulgaris)
PF03063
(Prismane)
3 ALA A  97
GLY A  45
SER A  57
None
0.59A 2ivuA-1oa1A:
undetectable
2ivuA-1oa1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0z SENSOR KINASE CITA

(Klebsiella
pneumoniae)
PF17203
(sCache_3_2)
3 ALA A  87
GLY A 108
SER A  24
None
None
NA  A1633 (-2.4A)
0.60A 2ivuA-1p0zA:
undetectable
2ivuA-1p0zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE


(Saccharomyces
cerevisiae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
3 ALA A 392
GLY A 413
SER A 446
None
None
TPP  A 557 ( 2.4A)
0.38A 2ivuA-1pvdA:
undetectable
2ivuA-1pvdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum)
PF00733
(Asn_synthase)
PF09147
(DUF1933)
3 ALA A 428
GLY A 248
SER A 347
None
0.56A 2ivuA-1q15A:
undetectable
2ivuA-1q15A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE


(Pseudomonas
putida)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
3 ALA A 181
GLY A 158
SER A 194
None
0.59A 2ivuA-1q1rA:
undetectable
2ivuA-1q1rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)


(Burkholderia
glumae)
no annotation 3 ALA E 226
GLY E 264
SER E 259
None
0.57A 2ivuA-1qgeE:
undetectable
2ivuA-1qgeE:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1


(Canis lupus)
PF00151
(Lipase)
PF01477
(PLAT)
3 ALA A 155
GLY A 216
SER A 266
None
0.60A 2ivuA-1rp1A:
undetectable
2ivuA-1rp1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450


(Streptomyces
coelicolor)
PF00067
(p450)
3 ALA A 245
GLY A 356
SER A 363
PIM  A 431 (-3.6A)
None
None
0.56A 2ivuA-1s1fA:
undetectable
2ivuA-1s1fA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT


(Thauera
aromatica)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
3 ALA A 509
GLY A 519
SER A 485
None
0.53A 2ivuA-1sb3A:
undetectable
2ivuA-1sb3A:
17.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ALA A 389
GLY A 441
SER A 499
None
0.46A 2ivuA-1snxA:
22.5
2ivuA-1snxA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE


(Shewanella
massilia)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
3 ALA A 745
GLY A  79
SER A 788
None
0.58A 2ivuA-1tmoA:
undetectable
2ivuA-1tmoA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2


(Streptomyces
coelicolor)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
3 ALA B  45
GLY B 224
SER B 202
None
0.59A 2ivuA-1tqyB:
undetectable
2ivuA-1tqyB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI


(Escherichia
coli)
PF00141
(peroxidase)
3 ALA A 505
GLY A 620
SER A 463
None
0.59A 2ivuA-1u2lA:
undetectable
2ivuA-1u2lA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzj FIBRILLIN-1

(Homo sapiens)
PF00683
(TB)
PF07645
(EGF_CA)
3 ALA A1560
GLY A1591
SER A1499
None
0.53A 2ivuA-1uzjA:
undetectable
2ivuA-1uzjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III


(Schizosaccharomyces
pombe)
PF00291
(PALP)
3 ALA A  24
GLY A 160
SER A  66
None
0.60A 2ivuA-1v71A:
undetectable
2ivuA-1v71A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III


(Schizosaccharomyces
pombe)
PF00291
(PALP)
3 ALA A 234
GLY A 183
SER A 308
None
PLP  A 350 (-3.3A)
PLP  A 350 (-2.8A)
0.60A 2ivuA-1v71A:
undetectable
2ivuA-1v71A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1


(Pyrococcus
furiosus)
PF00291
(PALP)
3 ALA B 296
GLY B 227
SER B 371
None
PLP  B 400 (-3.5A)
PLP  B 400 (-2.6A)
0.51A 2ivuA-1wdwB:
undetectable
2ivuA-1wdwB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE


(Escherichia
coli)
PF08282
(Hydrolase_3)
3 ALA A 176
GLY A  16
SER A  47
SO4  A 501 (-3.7A)
None
None
0.57A 2ivuA-1xviA:
undetectable
2ivuA-1xviA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana)
PF01408
(GFO_IDH_MocA)
3 ALA A  44
GLY A  35
SER A  65
None
0.60A 2ivuA-1ydwA:
undetectable
2ivuA-1ydwA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN B1A CHAIN

(Riftia
pachyptila)
PF00042
(Globin)
3 ALA C 114
GLY C 139
SER C 145
None
0.58A 2ivuA-1yhuC:
undetectable
2ivuA-1yhuC:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjg SURFACE PROTEIN VSPA

(Borrelia
turicatae)
PF01441
(Lipoprotein_6)
3 ALA A 104
GLY A  97
SER A  67
None
0.50A 2ivuA-1yjgA:
3.5
2ivuA-1yjgA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym0 FIBRINOTIC ENZYME
COMPONENT B
FIBRINOTIC ENZYME
COMPONENT B


(Eisenia fetida;
Eisenia fetida)
PF00089
(Trypsin)
no annotation
3 ALA B   9
GLY B   2
SER A 200
None
0.54A 2ivuA-1ym0B:
undetectable
2ivuA-1ym0B:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii)
PF00258
(Flavodoxin_1)
3 ALA A 109
GLY A  53
SER A  73
None
0.52A 2ivuA-1yobA:
undetectable
2ivuA-1yobA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE


(Burkholderia
cepacia)
PF00202
(Aminotran_3)
3 ALA A 245
GLY A 140
SER A 215
PLP  A 434 (-3.6A)
PLP  A 434 ( 3.9A)
MES  A 435 (-3.2A)
0.56A 2ivuA-1z3zA:
undetectable
2ivuA-1z3zA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcm F1845 FIMBRIAL
PROTEIN


(Escherichia
coli)
no annotation 3 ALA B  56
GLY B 109
SER B  91
None
0.50A 2ivuA-2bcmB:
undetectable
2ivuA-2bcmB:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1


(Bos taurus)
PF00115
(COX1)
3 ALA A 276
GLY A 269
SER A 255
None
0.58A 2ivuA-2eijA:
undetectable
2ivuA-2eijA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)


(Severe acute
respiratory
syndrome-related
coronavirus)
PF01661
(Macro)
3 ALA A  39
GLY A 131
SER A 140
None
0.42A 2ivuA-2favA:
undetectable
2ivuA-2favA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI


(Saccharopolyspora
erythraea)
PF08659
(KR)
3 ALA A1591
GLY A1766
SER A1773
None
0.39A 2ivuA-2fr1A:
undetectable
2ivuA-2fr1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE


(Aquifex
aeolicus)
PF02153
(PDH)
3 ALA A 150
GLY A 195
SER A  48
None
0.53A 2ivuA-2g5cA:
undetectable
2ivuA-2g5cA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga0 SURFACE PROTEIN VSPA

(Borrelia
turicatae)
PF01441
(Lipoprotein_6)
3 ALA A 104
GLY A  97
SER A  67
None
0.49A 2ivuA-2ga0A:
3.4
2ivuA-2ga0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024


(Pseudomonas
aeruginosa)
PF03060
(NMO)
3 ALA A 103
GLY A 151
SER A 178
FMN  A1904 (-3.1A)
NIS  A 500 (-2.8A)
FMN  A1904 (-3.2A)
0.38A 2ivuA-2gjnA:
undetectable
2ivuA-2gjnA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E


(Pisum sativum)
PF00856
(SET)
PF09273
(Rubis-subs-bind)
3 ALA A 297
GLY A 435
SER A 171
None
0.59A 2ivuA-2h21A:
undetectable
2ivuA-2h21A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
3 ALA A 659
GLY A 713
SER A 771
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.8A)
0.41A 2ivuA-2henA:
24.1
2ivuA-2henA:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iks DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR


(Escherichia
coli)
PF00532
(Peripla_BP_1)
3 ALA A 217
GLY A 252
SER A 246
None
0.50A 2ivuA-2iksA:
undetectable
2ivuA-2iksA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1


(Rattus
norvegicus)
PF01161
(PBP)
3 ALA A 171
GLY A 108
SER A 176
None
0.38A 2ivuA-2iqxA:
undetectable
2ivuA-2iqxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae)
PF00005
(ABC_tran)
3 ALA A1733
GLY A1943
SER A1863
None
0.59A 2ivuA-2ix8A:
undetectable
2ivuA-2ix8A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE


(Homo sapiens)
PF00282
(Pyridoxal_deC)
3 ALA A 300
GLY A 151
SER A 193
None
PLP  A1494 (-3.5A)
PLP  A1494 ( 4.1A)
0.59A 2ivuA-2jisA:
undetectable
2ivuA-2jisA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o34 HYPOTHETICAL PROTEIN

(Desulfovibrio
vulgaris)
no annotation 3 ALA A 199
GLY A 129
SER A 165
NA  A 501 ( 4.8A)
NA  A 503 ( 4.2A)
None
0.58A 2ivuA-2o34A:
undetectable
2ivuA-2o34A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1


(Homo sapiens)
PF00151
(Lipase)
PF01477
(PLAT)
3 ALA A 174
GLY A 234
SER A 284
None
NA  A 480 (-4.3A)
None
0.55A 2ivuA-2pplA:
undetectable
2ivuA-2pplA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2


(Homo sapiens)
PF00151
(Lipase)
PF01477
(PLAT)
3 ALA A 155
GLY A 216
SER A 266
None
0.53A 2ivuA-2pvsA:
undetectable
2ivuA-2pvsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA


(Mus musculus;
Paraburkholderia
xenovorans)
PF01007
(IRK)
3 ALA A 259
GLY A 163
SER A 168
None
0.56A 2ivuA-2qksA:
undetectable
2ivuA-2qksA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ALA A 651
GLY A 705
SER A 763
PTR  A 701 ( 4.7A)
None
None
0.28A 2ivuA-2qobA:
33.4
2ivuA-2qobA:
29.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
3 ALA A 705
GLY A 759
SER A 817
None
0.27A 2ivuA-2r2pA:
35.3
2ivuA-2r2pA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei)
PF00026
(Asp)
3 ALA A  87
GLY A 131
SER A  41
None
0.48A 2ivuA-2rmpA:
undetectable
2ivuA-2rmpA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica)
PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3)
3 ALA A 513
GLY A 410
SER A 469
None
0.57A 2ivuA-2uvfA:
undetectable
2ivuA-2uvfA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus)
PF00294
(PfkB)
3 ALA A  54
GLY A  34
SER A  69
None
KDG  A1313 ( 3.3A)
None
0.46A 2ivuA-2varA:
undetectable
2ivuA-2varA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE


(Kluyveromyces
lactis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
3 ALA A 392
GLY A 413
SER A 446
None
TPP  A 600 (-4.9A)
TPP  A 600 (-2.7A)
0.34A 2ivuA-2vk4A:
undetectable
2ivuA-2vk4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei)
PF00686
(CBM_20)
PF00723
(Glyco_hydro_15)
3 ALA A  84
GLY A  22
SER A  55
None
0.55A 2ivuA-2vn7A:
undetectable
2ivuA-2vn7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC


(Mycobacterium
tuberculosis)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
3 ALA A 363
GLY A  76
SER A 200
ADP  A1490 (-3.5A)
ADP  A1490 (-3.1A)
None
0.55A 2ivuA-2vosA:
undetectable
2ivuA-2vosA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vri NON-STRUCTURAL
PROTEIN 3


(Human
coronavirus
NL63)
PF01661
(Macro)
3 ALA A  31
GLY A 121
SER A 130
None
0.38A 2ivuA-2vriA:
undetectable
2ivuA-2vriA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3w DIHYDROFOLATE
REDUCTASE


(Mycobacterium
avium)
PF00186
(DHFR_1)
3 ALA A 134
GLY A 103
SER A  53
NDP  A1169 ( 3.8A)
NDP  A1169 ( 3.8A)
NDP  A1169 ( 3.9A)
0.53A 2ivuA-2w3wA:
undetectable
2ivuA-2w3wA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5o ALPHA-L-ARABINOFURAN
OSIDASE


(Fusarium
graminearum)
no annotation 3 ALA A 287
GLY A 246
SER A 253
None
0.55A 2ivuA-2w5oA:
2.5
2ivuA-2w5oA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus)
PF00258
(Flavodoxin_1)
3 ALA A 110
GLY A  54
SER A  74
None
0.59A 2ivuA-2wc1A:
undetectable
2ivuA-2wc1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE


(Lactococcus
lactis)
PF13419
(HAD_2)
3 ALA A 113
GLY A 174
SER A 181
None
0.49A 2ivuA-2wf7A:
undetectable
2ivuA-2wf7A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwv N,N'-DIACETYLCHITOBI
OSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT


(Escherichia
coli)
PF02255
(PTS_IIA)
3 ALA A  87
GLY A  16
SER A  44
None
0.59A 2ivuA-2wwvA:
undetectable
2ivuA-2wwvA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqr INVERTASE INHIBITOR

(Nicotiana
tabacum)
PF04043
(PMEI)
3 ALA B  88
GLY B 139
SER B 107
None
0.58A 2ivuA-2xqrB:
2.3
2ivuA-2xqrB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris)
PF04203
(Sortase)
3 ALA A 156
GLY A 183
SER A 199
None
0.59A 2ivuA-2xwgA:
undetectable
2ivuA-2xwgA:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
3 ALA A 651
GLY A 705
SER A 763
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-3.2A)
0.16A 2ivuA-2xyuA:
27.4
2ivuA-2xyuA:
34.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B


(Prochlorococcus
marinus)
PF00148
(Oxidored_nitro)
PF08369
(PCP_red)
3 ALA D 133
GLY D 173
SER D  22
None
0.56A 2ivuA-2ynmD:
undetectable
2ivuA-2ynmD:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus)
PF00266
(Aminotran_5)
3 ALA A 223
GLY A  86
SER A 135
PLP  A 501 (-3.4A)
PLP  A 501 ( 4.8A)
PLP  A 501 ( 3.7A)
0.58A 2ivuA-3a9xA:
undetectable
2ivuA-3a9xA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like)
3 ALA A  95
GLY A  46
SER A  61
None
0.56A 2ivuA-3abzA:
undetectable
2ivuA-3abzA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE


(Neospora
caninum)
PF01150
(GDA1_CD39)
3 ALA A 165
GLY A 255
SER A 299
None
0.51A 2ivuA-3agrA:
undetectable
2ivuA-3agrA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE


(Neospora
caninum)
PF01150
(GDA1_CD39)
3 ALA A 165
GLY A 304
SER A 299
None
0.60A 2ivuA-3agrA:
undetectable
2ivuA-3agrA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
3 ALA A 554
GLY A 267
SER A 692
None
0.50A 2ivuA-3aqpA:
2.0
2ivuA-3aqpA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
3 ALA A 487
GLY A 443
SER A 458
None
SF4  A 602 ( 4.3A)
None
0.60A 2ivuA-3b0hA:
undetectable
2ivuA-3b0hA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0p TRNA-DIHYDROURIDINE
SYNTHASE


(Thermus
thermophilus)
PF01207
(Dus)
3 ALA A  65
GLY A 101
SER A  95
None
0.54A 2ivuA-3b0pA:
3.9
2ivuA-3b0pA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bew MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B21


(Gallus gallus)
PF00129
(MHC_I)
PF07654
(C1-set)
3 ALA A 201
GLY A 266
SER A 261
None
0.60A 2ivuA-3bewA:
undetectable
2ivuA-3bewA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT


(Escherichia
coli)
PF13085
(Fer2_3)
PF13183
(Fer4_8)
3 ALA B 115
GLY B 169
SER B 197
None
0.54A 2ivuA-3cirB:
undetectable
2ivuA-3cirB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Vibrio cholerae)
PF01979
(Amidohydro_1)
3 ALA A 271
GLY A  64
SER A  87
None
0.59A 2ivuA-3egjA:
undetectable
2ivuA-3egjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejf NON-STRUCTURAL
PROTEIN 3


(Avian
coronavirus)
PF01661
(Macro)
3 ALA A  38
GLY A 130
SER A 139
None
0.45A 2ivuA-3ejfA:
undetectable
2ivuA-3ejfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3


(Human
coronavirus
229E)
PF01661
(Macro)
3 ALA A  34
GLY A 124
SER A 133
None
0.57A 2ivuA-3ejgA:
undetectable
2ivuA-3ejgA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE


(Rhodopseudomonas
palustris)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
3 ALA P 174
GLY P 151
SER P 187
None
0.57A 2ivuA-3fg2P:
undetectable
2ivuA-3fg2P:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE


(Desulfovibrio
gigas)
PF00890
(FAD_binding_2)
3 ALA A 178
GLY A  35
SER A  67
None
FAD  A1000 (-3.3A)
FAD  A1000 (-2.9A)
0.57A 2ivuA-3gyxA:
undetectable
2ivuA-3gyxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Corynebacterium
glutamicum)
PF00356
(LacI)
PF13377
(Peripla_BP_3)
3 ALA A 228
GLY A 193
SER A 196
None
0.59A 2ivuA-3h5tA:
undetectable
2ivuA-3h5tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
3 ALA A1587
GLY A1028
SER A1218
None
0.50A 2ivuA-3hmjA:
undetectable
2ivuA-3hmjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqf RESTRICTION
ENDONUCLEASE


(Escherichia
coli)
PF09217
(EcoRII-N)
3 ALA A  80
GLY A  39
SER A 106
None
0.60A 2ivuA-3hqfA:
undetectable
2ivuA-3hqfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT


(Eubacterium
barkeri;
Eubacterium
barkeri)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF02738
(Ald_Xan_dh_C2)
3 ALA A 308
GLY B 247
SER A  44
None
0.56A 2ivuA-3hrdA:
undetectable
2ivuA-3hrdA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica)
PF02615
(Ldh_2)
3 ALA A 183
GLY A 190
SER A 150
NAD  A 401 (-3.3A)
None
None
0.55A 2ivuA-3i0pA:
undetectable
2ivuA-3i0pA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1


(Thermus
thermophilus)
PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S)
3 ALA 1 406
GLY 1 362
SER 1 398
None
None
SF4  1 439 ( 4.5A)
0.58A 2ivuA-3i9v1:
undetectable
2ivuA-3i9v1:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum)
PF00291
(PALP)
3 ALA A 268
GLY A 217
SER A 344
None
LLP  A  91 ( 3.4A)
LLP  A  91 ( 2.7A)
0.54A 2ivuA-3iauA:
undetectable
2ivuA-3iauA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE


(Desulfovibrio
vulgaris)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 ALA A 191
GLY A 197
SER A 204
None
0.59A 2ivuA-3iwaA:
undetectable
2ivuA-3iwaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10


(Schizosaccharomyces
pombe)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2)
3 ALA B 501
GLY B 620
SER B 627
None
0.59A 2ivuA-3jb9B:
undetectable
2ivuA-3jb9B:
16.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
3 ALA A 665
GLY A 719
SER A 777
None
GOL  A 403 (-3.4A)
None
0.53A 2ivuA-3kulA:
35.6
2ivuA-3kulA:
31.36