SIMILAR PATTERNS OF AMINO ACIDS FOR 2IVU_A_ZD6A3015_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 212
VAL A 219
LYS A 232
GLU A 245
TYR A 282
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.58A 2ivuA-1py5A:
28.4		 2ivuA-1py5A:
26.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 595
GLY A 596
VAL A 603
LYS A 623
GLU A 640
LEU A 644
TYR A 672
LEU A 799
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
 0.60A 2ivuA-1t46A:
33.2		 2ivuA-1t46A:
45.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
ASP A 169
 None
 0.83A 2ivuA-1u5qA:
27.3		 2ivuA-1u5qA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
TYR A 107
 None
 0.60A 2ivuA-1u5qA:
27.3		 2ivuA-1u5qA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
LYS A  38
LEU A  82
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.64A 2ivuA-1zltA:
25.0		 2ivuA-1zltA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
GLY A  20
VAL A  27
LYS A  42
LEU A  68
LEU A  91
 None
 0.53A 2ivuA-1zwsA:
25.7		 2ivuA-1zwsA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
ASP A 161
 None
 0.90A 2ivuA-2a2aA:
26.3		 2ivuA-2a2aA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
 None
 0.68A 2ivuA-2a2aA:
26.3		 2ivuA-2a2aA:
27.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
GLY X  18
VAL X  25
LYS X  39
GLU X  54
TYR X  84
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
 0.61A 2ivuA-2dq7X:
35.9		 2ivuA-2dq7X:
34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  59
LEU A  63
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
ADP  A 500 (-4.3A)
 0.47A 2ivuA-2f9gA:
11.7		 2ivuA-2f9gA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
TYR A 107
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 ( 4.5A)
None
None
None
STU  A 400 (-4.5A)
 0.75A 2ivuA-2gcdA:
28.2		 2ivuA-2gcdA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
GLY A 274
VAL A 281
LYS A 295
TYR A 340
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
 0.52A 2ivuA-2h8hA:
30.8		 2ivuA-2h8hA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  55
GLY A  56
VAL A  63
LYS A  78
LEU A  98
LEU A 122
 None
 0.54A 2ivuA-2hw6A:
20.9		 2ivuA-2hw6A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  38
GLY A  39
VAL A  46
GLU A  83
LEU A  87
LEU A 114
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
None
None
None
 0.50A 2ivuA-2iwiA:
25.3		 2ivuA-2iwiA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
GLY A  26
VAL A  33
LEU A  77
LEU A 101
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
None
None
ATP  A 381 ( 4.8A)
 0.46A 2ivuA-2phkA:
26.1		 2ivuA-2phkA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
GLY A  26
VAL A  33
LYS A  48
LEU A  77
LEU A 101
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
 0.47A 2ivuA-2phkA:
26.1		 2ivuA-2phkA:
27.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 488
GLU A 534
VAL A 564
TYR A 566
LEU A 633
ASP A 644
 None
 0.84A 2ivuA-2psqA:
37.8		 2ivuA-2psqA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
ASP A 644
 None
 0.64A 2ivuA-2psqA:
37.8		 2ivuA-2psqA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
 0.66A 2ivuA-2w4kA:
26.1		 2ivuA-2w4kA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  31
VAL A  38
LYS A  53
LEU A  81
LEU A 105
LEU A 160
ASP A 171
 B49  A1294 (-4.0A)
None
None
None
None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.60A 2ivuA-2y7jA:
26.7		 2ivuA-2y7jA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
None
None
 0.70A 2ivuA-2yabA:
26.5		 2ivuA-2yabA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
GLY A  98
VAL A 105
GLU A 143
LEU A 147
LEU A 170
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
None
None
STU  A 400 (-4.7A)
 0.66A 2ivuA-3a62A:
23.2		 2ivuA-3a62A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
GLY A  98
VAL A 105
LYS A 123
GLU A 143
LEU A 147
LEU A 170
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
None
 0.72A 2ivuA-3a62A:
23.2		 2ivuA-3a62A:
27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 488
LYS A 517
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.72A 2ivuA-3b2tA:
29.3		 2ivuA-3b2tA:
50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
GLY A 488
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.55A 2ivuA-3b2tA:
29.3		 2ivuA-3b2tA:
50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
ASP A 644
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.45A 2ivuA-3b2tA:
29.3		 2ivuA-3b2tA:
50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
VAL A 561
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.80A 2ivuA-3c4fA:
33.9		 2ivuA-3c4fA:
51.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
GLY A  16
VAL A  23
LYS A  38
GLU A  50
TYR A 119
 DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
None
None
DRK  A 384 (-4.4A)
 0.49A 2ivuA-3eb0A:
23.3		 2ivuA-3eb0A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  44
GLY A  45
VAL A  52
LYS A  67
GLU A  89
LEU A  93
LEU A 118
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
None
985  A   1 ( 4.0A)
 0.78A 2ivuA-3f2aA:
20.1		 2ivuA-3f2aA:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
GLY A 834
VAL A 841
LYS A 861
GLU A 878
LEU A 882
VAL A 909
TYR A 911
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
 0.36A 2ivuA-3hngA:
32.4		 2ivuA-3hngA:
42.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  39
GLY A  40
VAL A  47
LEU A  84
LEU A 108
TYR A 112
ALA A 113
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
QUE  A   1 (-2.9A)
 0.56A 2ivuA-3lm5A:
25.8		 2ivuA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  39
GLY A  40
VAL A  47
LEU A 108
TYR A 112
ALA A 113
LEU A 165
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
QUE  A   1 (-2.9A)
 0.67A 2ivuA-3lm5A:
25.8		 2ivuA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
GLY A  50
VAL A  57
LYS A  72
GLU A  91
LEU A  95
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
None
None
None
None
 0.78A 2ivuA-3mvjA:
26.0		 2ivuA-3mvjA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
GLY A  50
VAL A  57
LYS A  72
GLU A  91
LEU A  95
TYR A 122
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
None
None
None
None
 0.62A 2ivuA-3mvjA:
26.0		 2ivuA-3mvjA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
GLY A  89
VAL A  96
LYS A 111
TYR A 161
ALA A 162
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
SO4  A   5 (-2.8A)
None
JOZ  A 361 (-3.8A)
None
 0.69A 2ivuA-3nuuA:
26.9		 2ivuA-3nuuA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
GLY A 193
LYS A 215
GLU A 234
LEU A 238
LEU A 261
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.49A 2ivuA-3nyoA:
25.8		 2ivuA-3nyoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
GLY A 193
VAL A 200
LYS A 215
LEU A 238
LEU A 261
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.45A 2ivuA-3nyoA:
25.8		 2ivuA-3nyoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		7 LEU A 348
GLY A 349
VAL A 356
LYS A 371
GLU A 390
LEU A 394
TYR A 422
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.3A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.3A)
None
None
ANP  A 800 (-4.2A)
 0.68A 2ivuA-3pfqA:
22.6		 2ivuA-3pfqA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
GLY A 727
VAL A 734
LYS A 753
LEU A 796
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.4A)
 0.50A 2ivuA-3pp0A:
34.3		 2ivuA-3pp0A:
32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
LYS A 105
GLU A 124
LEU A 128
TYR A 155
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 (-4.4A)
EDO  A 417 (-3.7A)
 0.76A 2ivuA-3qfvA:
23.8		 2ivuA-3qfvA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
LYS A 105
GLU A 124
LEU A 151
TYR A 155
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 (-4.4A)
EDO  A 417 (-3.7A)
 0.78A 2ivuA-3qfvA:
23.8		 2ivuA-3qfvA:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
GLU A 531
VAL A 561
TYR A 563
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
 0.60A 2ivuA-3tt0A:
33.5		 2ivuA-3tt0A:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
LYS A 514
GLU A 531
VAL A 561
TYR A 563
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
 0.52A 2ivuA-3tt0A:
33.5		 2ivuA-3tt0A:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
LYS A 514
VAL A 561
TYR A 563
ALA A 564
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
 0.62A 2ivuA-3tt0A:
33.5		 2ivuA-3tt0A:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.59A 2ivuA-3tt0A:
33.5		 2ivuA-3tt0A:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
VAL A 561
TYR A 563
ALA A 564
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
 0.60A 2ivuA-3tt0A:
33.5		 2ivuA-3tt0A:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
VAL A 848
LYS A 868
GLU A 885
LEU A 889
VAL A 916
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
None
None
None
None
 0.42A 2ivuA-3vidA:
31.9		 2ivuA-3vidA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 139
GLY A 140
VAL A 147
LEU A 208
TYR A 212
ALA A 213
LEU A 263
 N13  A 501 (-3.7A)
None
N13  A 501 ( 4.7A)
N13  A 501 (-4.9A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-4.5A)
 0.60A 2ivuA-3w18A:
22.8		 2ivuA-3w18A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 139
VAL A 147
LYS A 162
LEU A 208
TYR A 212
ALA A 213
LEU A 263
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 (-2.9A)
N13  A 501 (-4.9A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-4.5A)
 0.65A 2ivuA-3w18A:
22.8		 2ivuA-3w18A:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
GLU A 885
LEU A 889
VAL A 916
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
 0.50A 2ivuA-3wzdA:
26.5		 2ivuA-3wzdA:
44.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
VAL A  18
LYS A  33
GLU A  50
LEU A  54
LEU A  77
LEU A 132
 38R  A 350 ( 3.9A)
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
38R  A 350 (-4.3A)
 0.62A 2ivuA-3zduA:
25.0		 2ivuA-3zduA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
GLY A  84
VAL A  91
LEU A 152
TYR A 156
ALA A 157
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
None
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-4.6A)
 0.64A 2ivuA-4af3A:
20.3		 2ivuA-4af3A:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
GLY A 841
VAL A 848
GLU A 885
LEU A 889
VAL A 916
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
None
None
B49  A2000 (-4.8A)
 0.39A 2ivuA-4agdA:
32.0		 2ivuA-4agdA:
43.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  11
VAL A  18
LYS A  33
GLU A  51
LEU A  55
LEU A  78
TYR A  82
LEU A 133
 D15  A 500 (-3.8A)
D15  A 500 (-4.6A)
D15  A 500 ( 4.1A)
None
None
None
D15  A 500 (-4.8A)
D15  A 500 (-4.5A)
 0.63A 2ivuA-4aguA:
26.1		 2ivuA-4aguA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A  84
VAL A  91
LYS A 106
GLU A 125
LEU A 129
TYR A 156
ASP A 219
 None
None
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
None
 0.75A 2ivuA-4aw2A:
23.9		 2ivuA-4aw2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A  84
VAL A  91
LYS A 106
GLU A 125
LEU A 152
TYR A 156
ASP A 219
 None
None
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
None
 0.82A 2ivuA-4aw2A:
23.9		 2ivuA-4aw2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
GLY A 247
VAL A 254
GLU A 288
LEU A 292
TYR A 320
ALA A 321
ASP A 382
 None
 0.71A 2ivuA-4c0tA:
24.7		 2ivuA-4c0tA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
GLY A 247
VAL A 254
LYS A 269
LEU A 292
TYR A 320
ALA A 321
 None
 0.51A 2ivuA-4c0tA:
24.7		 2ivuA-4c0tA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
GLY A 247
VAL A 254
TYR A 320
ALA A 321
LEU A 371
ASP A 382
 None
 0.63A 2ivuA-4c0tA:
24.7		 2ivuA-4c0tA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
LYS A  38
GLU A  55
LEU A  59
LEU A  84
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
None
 0.66A 2ivuA-4euuA:
18.3		 2ivuA-4euuA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 377
GLY A 378
VAL A 385
LYS A 402
ALA A 451
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.78A 2ivuA-4fl3A:
30.2		 2ivuA-4fl3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 377
GLY A 378
VAL A 385
LYS A 402
LEU A 446
ALA A 451
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
 0.36A 2ivuA-4fl3A:
30.2		 2ivuA-4fl3A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
GLY A 856
VAL A 863
LYS A 882
LEU A 902
TYR A 931
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 ( 4.7A)
 0.77A 2ivuA-4gl9A:
34.1		 2ivuA-4gl9A:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 156
GLY A 157
VAL A 164
LYS A 179
GLU A 198
LEU A 202
TYR A 229
ALA A 230
ASP A 292
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
None
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
0XZ  A 501 ( 3.4A)
 0.54A 2ivuA-4gv1A:
25.6		 2ivuA-4gv1A:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 132
GLY A 133
VAL A 140
LYS A 158
ALA A 208
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.8A)
1G0  A 401 (-4.6A)
 0.45A 2ivuA-4id7A:
20.1		 2ivuA-4id7A:
33.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
VAL A 281
LYS A 295
TYR A 340
LEU A 393
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.76A 2ivuA-4k11A:
30.6		 2ivuA-4k11A:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
GLY A 479
VAL A 486
LYS A 508
GLU A 525
VAL A 555
TYR A 557
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
None
ACP  A 801 (-4.4A)
 0.56A 2ivuA-4k33A:
30.8		 2ivuA-4k33A:
51.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
VAL A 486
LYS A 508
GLU A 525
VAL A 555
TYR A 557
ALA A 558
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
None
ACP  A 801 (-3.7A)
ACP  A 801 (-4.4A)
 0.54A 2ivuA-4k33A:
30.8		 2ivuA-4k33A:
51.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 386
GLY A 387
LYS A 409
GLU A 428
LEU A 432
TYR A 460
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
None
None
None
None
PZW  A 801 (-3.2A)
 0.70A 2ivuA-4q9zA:
24.5		 2ivuA-4q9zA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 386
GLY A 387
VAL A 394
LYS A 409
LEU A 432
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.61A 2ivuA-4q9zA:
24.5		 2ivuA-4q9zA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 793
GLY A 794
VAL A 801
LYS A 821
GLU A 830
LEU A 864
 ADP  A1501 ( 3.7A)
ADP  A1501 (-3.3A)
ADP  A1501 (-3.8A)
ADP  A1501 (-2.7A)
ADP  A1501 ( 4.8A)
None
 0.31A 2ivuA-4qpmA:
21.6		 2ivuA-4qpmA:
24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
LYS A 644
GLU A 661
LEU A 689
TYR A 693
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
 0.46A 2ivuA-4rt7A:
26.2		 2ivuA-4rt7A:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
LYS A 644
LEU A 689
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.45A 2ivuA-4rt7A:
26.2		 2ivuA-4rt7A:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
GLY A  15
VAL A  22
LYS A  37
GLU A  52
TYR A  83
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.56A 2ivuA-4ueuA:
34.0		 2ivuA-4ueuA:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 151
VAL A 158
LYS A 171
LEU A 218
ALA A 223
LEU A 275
ASP A 294
 None
 0.87A 2ivuA-4uy9A:
26.2		 2ivuA-4uy9A:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
GLY A 194
LYS A 216
LEU A 239
LEU A 262
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
None
None
ANW  A 601 (-4.9A)
 0.52A 2ivuA-4wboA:
25.9		 2ivuA-4wboA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
GLY A 194
VAL A 201
LYS A 216
LEU A 239
LEU A 262
 ANW  A 601 ( 4.0A)
None
None
None
None
None
 0.36A 2ivuA-4wboA:
25.9		 2ivuA-4wboA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 473
GLY A 474
VAL A 481
LYS A 503
GLU A 520
VAL A 550
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
 0.52A 2ivuA-4xcuA:
33.3		 2ivuA-4xcuA:
52.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
GLY A 617
VAL A 624
LEU A 689
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.36A 2ivuA-4xufA:
31.5		 2ivuA-4xufA:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
LYS A 644
GLU A 661
LEU A 689
TYR A 693
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
 0.66A 2ivuA-4xufA:
31.5		 2ivuA-4xufA:
46.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
VAL A 201
LYS A 216
LEU A 239
LEU A 262
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
 0.62A 2ivuA-4yhjA:
23.4		 2ivuA-4yhjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  34
GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
None
None
None
 0.54A 2ivuA-4ysjA:
26.8		 2ivuA-4ysjA:
20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
GLY A 485
VAL A 492
GLU A 531
VAL A 561
TYR A 563
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.62A 2ivuA-5a46A:
33.2		 2ivuA-5a46A:
44.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
GLY A 485
VAL A 492
LYS A 514
GLU A 531
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.59A 2ivuA-5a46A:
33.2		 2ivuA-5a46A:
44.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY A  23
VAL A  30
LYS A  46
GLU A  63
LEU A  67
LEU A  90
TYR A  94
LEU A 145
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
GOL  A 404 ( 3.1A)
None
None
None
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.66A 2ivuA-5ci7A:
28.6		 2ivuA-5ci7A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  63
VAL A  70
LYS A  85
LEU A 130
TYR A 134
ALA A 135
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
 0.46A 2ivuA-5es1A:
24.6		 2ivuA-5es1A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
GLY A 100
VAL A 107
LYS A 122
LEU A 168
ALA A 173
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.9A)
5U5  A 401 (-4.7A)
 0.48A 2ivuA-5eykA:
26.0		 2ivuA-5eykA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
VAL A 911
LYS A 930
GLU A 947
LEU A 951
TYR A 980
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
None
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
 0.62A 2ivuA-5f1zA:
33.2		 2ivuA-5f1zA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 730
GLY A 731
VAL A 738
LYS A 758
GLU A 775
LEU A 779
LEU A 802
VAL A 804
TYR A 806
ALA A 807
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
None
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 (-4.6A)
 0.51A 2ivuA-5fm2A:
40.3		 2ivuA-5fm2A:
87.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
GLY A 600
VAL A 607
LYS A 627
GLU A 644
TYR A 676
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.0A)
 0.55A 2ivuA-5grnA:
26.4		 2ivuA-5grnA:
43.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
GLY A 600
VAL A 607
LYS A 627
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.47A 2ivuA-5grnA:
26.4		 2ivuA-5grnA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  28
VAL A  35
GLU A  66
LEU A  95
TYR A  99
ALA A 100
LEU A 158
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
FMT  A 404 ( 4.2A)
None
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
 0.70A 2ivuA-5idnA:
11.4		 2ivuA-5idnA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  35
GLU A  66
LEU A  70
LEU A  95
TYR A  99
ALA A 100
LEU A 158
 6A7  A 401 ( 4.5A)
FMT  A 404 ( 4.2A)
None
None
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
 0.74A 2ivuA-5idnA:
11.4		 2ivuA-5idnA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  45
GLY A  46
VAL A  53
LYS A  68
LEU A  85
LEU A 111
ASP A 175
 HC4  A 401 ( 4.8A)
None
None
HC4  A 401 (-2.7A)
None
None
HC4  A 401 (-4.0A)
 0.80A 2ivuA-5movA:
24.2		 2ivuA-5movA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  45
VAL A  53
LYS A  68
GLU A  81
LEU A  85
LEU A 111
ASP A 175
 HC4  A 401 ( 4.8A)
None
HC4  A 401 (-2.7A)
None
None
None
HC4  A 401 (-4.0A)
 0.92A 2ivuA-5movA:
24.2		 2ivuA-5movA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 7 LEU A  44
GLY A  45
VAL A  52
LYS A  67
GLU A  89
LEU A  93
LEU A 118
 None
None
7LK  A 401 (-4.9A)
None
None
None
None
 0.57A 2ivuA-5turA:
25.3		 2ivuA-5turA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 LEU A  17
GLY A  18
VAL A  25
LYS A  40
GLU A  59
TYR A  94
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
None
 0.53A 2ivuA-5u94A:
19.2		 2ivuA-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 8 GLY A 734
VAL A 741
LYS A 756
GLU A 774
LEU A 778
LEU A 811
TYR A 815
ASP A 877
 CJM  A1102 (-3.4A)
None
None
None
None
None
CJM  A1102 (-4.1A)
MG  A1101 (-2.5A)
 0.87A 2ivuA-6b3eA:
25.7		 2ivuA-6b3eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
GLY A 882
VAL A 889
LYS A 908
GLU A 925
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.5A)
 0.55A 2ivuA-6c7yA:
33.9		 2ivuA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 10 LEU A 730
GLY A 731
VAL A 738
GLU A 775
LEU A 779
LEU A 802
VAL A 804
TYR A 806
ALA A 807
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
None
None
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-4.3A)
 0.32A 2ivuA-6fekA:
45.5		 2ivuA-6fekA:
undetectable