SIMILAR PATTERNS OF AMINO ACIDS FOR 2IVU_A_ZD6A3015

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 212
VAL A 219
LYS A 232
GLU A 245
TYR A 282
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.58A 2ivuA-1py5A:
28.4		 2ivuA-1py5A:
26.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 595
GLY A 596
VAL A 603
LYS A 623
GLU A 640
LEU A 644
TYR A 672
LEU A 799
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
 0.60A 2ivuA-1t46A:
33.2		 2ivuA-1t46A:
45.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
ASP A 169
 None
 0.83A 2ivuA-1u5qA:
27.3		 2ivuA-1u5qA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
TYR A 107
 None
 0.60A 2ivuA-1u5qA:
27.3		 2ivuA-1u5qA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
LYS A  38
LEU A  82
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.64A 2ivuA-1zltA:
25.0		 2ivuA-1zltA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
GLY A  20
VAL A  27
LYS A  42
LEU A  68
LEU A  91
 None
 0.53A 2ivuA-1zwsA:
25.7		 2ivuA-1zwsA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
ASP A 161
 None
 0.90A 2ivuA-2a2aA:
26.3		 2ivuA-2a2aA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
 None
 0.68A 2ivuA-2a2aA:
26.3		 2ivuA-2a2aA:
27.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
GLY X  18
VAL X  25
LYS X  39
GLU X  54
TYR X  84
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
 0.61A 2ivuA-2dq7X:
35.9		 2ivuA-2dq7X:
34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  59
LEU A  63
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
ADP  A 500 (-4.3A)
 0.47A 2ivuA-2f9gA:
11.7		 2ivuA-2f9gA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
TYR A 107
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 ( 4.5A)
None
None
None
STU  A 400 (-4.5A)
 0.75A 2ivuA-2gcdA:
28.2		 2ivuA-2gcdA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
GLY A 274
VAL A 281
LYS A 295
TYR A 340
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
 0.52A 2ivuA-2h8hA:
30.8		 2ivuA-2h8hA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  55
GLY A  56
VAL A  63
LYS A  78
LEU A  98
LEU A 122
 None
 0.54A 2ivuA-2hw6A:
20.9		 2ivuA-2hw6A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  38
GLY A  39
VAL A  46
GLU A  83
LEU A  87
LEU A 114
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
None
None
None
 0.50A 2ivuA-2iwiA:
25.3		 2ivuA-2iwiA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
GLY A  26
VAL A  33
LEU A  77
LEU A 101
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
None
None
ATP  A 381 ( 4.8A)
 0.46A 2ivuA-2phkA:
26.1		 2ivuA-2phkA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
GLY A  26
VAL A  33
LYS A  48
LEU A  77
LEU A 101
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
 0.47A 2ivuA-2phkA:
26.1		 2ivuA-2phkA:
27.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 488
GLU A 534
VAL A 564
TYR A 566
LEU A 633
ASP A 644
 None
 0.84A 2ivuA-2psqA:
37.8		 2ivuA-2psqA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
ASP A 644
 None
 0.64A 2ivuA-2psqA:
37.8		 2ivuA-2psqA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
 0.66A 2ivuA-2w4kA:
26.1		 2ivuA-2w4kA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  31
VAL A  38
LYS A  53
LEU A  81
LEU A 105
LEU A 160
ASP A 171
 B49  A1294 (-4.0A)
None
None
None
None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.60A 2ivuA-2y7jA:
26.7		 2ivuA-2y7jA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
None
None
 0.70A 2ivuA-2yabA:
26.5		 2ivuA-2yabA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
GLY A  98
VAL A 105
GLU A 143
LEU A 147
LEU A 170
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
None
None
STU  A 400 (-4.7A)
 0.66A 2ivuA-3a62A:
23.2		 2ivuA-3a62A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
GLY A  98
VAL A 105
LYS A 123
GLU A 143
LEU A 147
LEU A 170
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
None
 0.72A 2ivuA-3a62A:
23.2		 2ivuA-3a62A:
27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 488
LYS A 517
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.72A 2ivuA-3b2tA:
29.3		 2ivuA-3b2tA:
50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
GLY A 488
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.55A 2ivuA-3b2tA:
29.3		 2ivuA-3b2tA:
50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
ASP A 644
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.45A 2ivuA-3b2tA:
29.3		 2ivuA-3b2tA:
50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
VAL A 561
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.80A 2ivuA-3c4fA:
33.9		 2ivuA-3c4fA:
51.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
GLY A  16
VAL A  23
LYS A  38
GLU A  50
TYR A 119
 DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
None
None
DRK  A 384 (-4.4A)
 0.49A 2ivuA-3eb0A:
23.3		 2ivuA-3eb0A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  44
GLY A  45
VAL A  52
LYS A  67
GLU A  89
LEU A  93
LEU A 118
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
None
985  A   1 ( 4.0A)
 0.78A 2ivuA-3f2aA:
20.1		 2ivuA-3f2aA:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
GLY A 834
VAL A 841
LYS A 861
GLU A 878
LEU A 882
VAL A 909
TYR A 911
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
 0.36A 2ivuA-3hngA:
32.4		 2ivuA-3hngA:
42.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  39
GLY A  40
VAL A  47
LEU A  84
LEU A 108
TYR A 112
ALA A 113
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
QUE  A   1 (-2.9A)
 0.56A 2ivuA-3lm5A:
25.8		 2ivuA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  39
GLY A  40
VAL A  47
LEU A 108
TYR A 112
ALA A 113
LEU A 165
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
QUE  A   1 (-2.9A)
 0.67A 2ivuA-3lm5A:
25.8		 2ivuA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
GLY A  50
VAL A  57
LYS A  72
GLU A  91
LEU A  95
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
None
None
None
None
 0.78A 2ivuA-3mvjA:
26.0		 2ivuA-3mvjA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
GLY A  50
VAL A  57
LYS A  72
GLU A  91
LEU A  95
TYR A 122
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
None
None
None
None
 0.62A 2ivuA-3mvjA:
26.0		 2ivuA-3mvjA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
GLY A  89
VAL A  96
LYS A 111
TYR A 161
ALA A 162
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
SO4  A   5 (-2.8A)
None
JOZ  A 361 (-3.8A)
None
 0.69A 2ivuA-3nuuA:
26.9		 2ivuA-3nuuA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
GLY A 193
LYS A 215
GLU A 234
LEU A 238
LEU A 261
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.49A 2ivuA-3nyoA:
25.8		 2ivuA-3nyoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
GLY A 193
VAL A 200
LYS A 215
LEU A 238
LEU A 261
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.45A 2ivuA-3nyoA:
25.8		 2ivuA-3nyoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		7 LEU A 348
GLY A 349
VAL A 356
LYS A 371
GLU A 390
LEU A 394
TYR A 422
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.3A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.3A)
None
None
ANP  A 800 (-4.2A)
 0.68A 2ivuA-3pfqA:
22.6		 2ivuA-3pfqA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
GLY A 727
VAL A 734
LYS A 753
LEU A 796
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.4A)
 0.50A 2ivuA-3pp0A:
34.3		 2ivuA-3pp0A:
32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
LYS A 105
GLU A 124
LEU A 128
TYR A 155
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 (-4.4A)
EDO  A 417 (-3.7A)
 0.76A 2ivuA-3qfvA:
23.8		 2ivuA-3qfvA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
LYS A 105
GLU A 124
LEU A 151
TYR A 155
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 (-4.4A)
EDO  A 417 (-3.7A)
 0.78A 2ivuA-3qfvA:
23.8		 2ivuA-3qfvA:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
GLU A 531
VAL A 561
TYR A 563
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
 0.60A 2ivuA-3tt0A:
33.5		 2ivuA-3tt0A:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
LYS A 514
GLU A 531
VAL A 561
TYR A 563
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
 0.52A 2ivuA-3tt0A:
33.5		 2ivuA-3tt0A:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
LYS A 514
VAL A 561
TYR A 563
ALA A 564
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
 0.62A 2ivuA-3tt0A:
33.5		 2ivuA-3tt0A:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.59A 2ivuA-3tt0A:
33.5		 2ivuA-3tt0A:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
VAL A 561
TYR A 563
ALA A 564
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
 0.60A 2ivuA-3tt0A:
33.5		 2ivuA-3tt0A:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
VAL A 848
LYS A 868
GLU A 885
LEU A 889
VAL A 916
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
None
None
None
None
 0.42A 2ivuA-3vidA:
31.9		 2ivuA-3vidA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 139
GLY A 140
VAL A 147
LEU A 208
TYR A 212
ALA A 213
LEU A 263
 N13  A 501 (-3.7A)
None
N13  A 501 ( 4.7A)
N13  A 501 (-4.9A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-4.5A)
 0.60A 2ivuA-3w18A:
22.8		 2ivuA-3w18A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 139
VAL A 147
LYS A 162
LEU A 208
TYR A 212
ALA A 213
LEU A 263
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 (-2.9A)
N13  A 501 (-4.9A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-4.5A)
 0.65A 2ivuA-3w18A:
22.8		 2ivuA-3w18A:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
GLU A 885
LEU A 889
VAL A 916
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
 0.50A 2ivuA-3wzdA:
26.5		 2ivuA-3wzdA:
44.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
VAL A  18
LYS A  33
GLU A  50
LEU A  54
LEU A  77
LEU A 132
 38R  A 350 ( 3.9A)
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
38R  A 350 (-4.3A)
 0.62A 2ivuA-3zduA:
25.0		 2ivuA-3zduA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
GLY A  84
VAL A  91
LEU A 152
TYR A 156
ALA A 157
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
None
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-4.6A)
 0.64A 2ivuA-4af3A:
20.3		 2ivuA-4af3A:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
GLY A 841
VAL A 848
GLU A 885
LEU A 889
VAL A 916
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
None
None
B49  A2000 (-4.8A)
 0.39A 2ivuA-4agdA:
32.0		 2ivuA-4agdA:
43.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  11
VAL A  18
LYS A  33
GLU A  51
LEU A  55
LEU A  78
TYR A  82
LEU A 133
 D15  A 500 (-3.8A)
D15  A 500 (-4.6A)
D15  A 500 ( 4.1A)
None
None
None
D15  A 500 (-4.8A)
D15  A 500 (-4.5A)
 0.63A 2ivuA-4aguA:
26.1		 2ivuA-4aguA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A  84
VAL A  91
LYS A 106
GLU A 125
LEU A 129
TYR A 156
ASP A 219
 None
None
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
None
 0.75A 2ivuA-4aw2A:
23.9		 2ivuA-4aw2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A  84
VAL A  91
LYS A 106
GLU A 125
LEU A 152
TYR A 156
ASP A 219
 None
None
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
None
 0.82A 2ivuA-4aw2A:
23.9		 2ivuA-4aw2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
GLY A 247
VAL A 254
GLU A 288
LEU A 292
TYR A 320
ALA A 321
ASP A 382
 None
 0.71A 2ivuA-4c0tA:
24.7		 2ivuA-4c0tA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
GLY A 247
VAL A 254
LYS A 269
LEU A 292
TYR A 320
ALA A 321
 None
 0.51A 2ivuA-4c0tA:
24.7		 2ivuA-4c0tA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
GLY A 247
VAL A 254
TYR A 320
ALA A 321
LEU A 371
ASP A 382
 None
 0.63A 2ivuA-4c0tA:
24.7		 2ivuA-4c0tA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
LYS A  38
GLU A  55
LEU A  59
LEU A  84
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
None
 0.66A 2ivuA-4euuA:
18.3		 2ivuA-4euuA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 377
GLY A 378
VAL A 385
LYS A 402
ALA A 451
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.78A 2ivuA-4fl3A:
30.2		 2ivuA-4fl3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 377
GLY A 378
VAL A 385
LYS A 402
LEU A 446
ALA A 451
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
 0.36A 2ivuA-4fl3A:
30.2		 2ivuA-4fl3A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
GLY A 856
VAL A 863
LYS A 882
LEU A 902
TYR A 931
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 ( 4.7A)
 0.77A 2ivuA-4gl9A:
34.1		 2ivuA-4gl9A:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 156
GLY A 157
VAL A 164
LYS A 179
GLU A 198
LEU A 202
TYR A 229
ALA A 230
ASP A 292
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
None
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
0XZ  A 501 ( 3.4A)
 0.54A 2ivuA-4gv1A:
25.6		 2ivuA-4gv1A:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 132
GLY A 133
VAL A 140
LYS A 158
ALA A 208
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.8A)
1G0  A 401 (-4.6A)
 0.45A 2ivuA-4id7A:
20.1		 2ivuA-4id7A:
33.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
VAL A 281
LYS A 295
TYR A 340
LEU A 393
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.76A 2ivuA-4k11A:
30.6		 2ivuA-4k11A:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
GLY A 479
VAL A 486
LYS A 508
GLU A 525
VAL A 555
TYR A 557
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
None
ACP  A 801 (-4.4A)
 0.56A 2ivuA-4k33A:
30.8		 2ivuA-4k33A:
51.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
VAL A 486
LYS A 508
GLU A 525
VAL A 555
TYR A 557
ALA A 558
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
None
ACP  A 801 (-3.7A)
ACP  A 801 (-4.4A)
 0.54A 2ivuA-4k33A:
30.8		 2ivuA-4k33A:
51.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 386
GLY A 387
LYS A 409
GLU A 428
LEU A 432
TYR A 460
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
None
None
None
None
PZW  A 801 (-3.2A)
 0.70A 2ivuA-4q9zA:
24.5		 2ivuA-4q9zA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 386
GLY A 387
VAL A 394
LYS A 409
LEU A 432
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.61A 2ivuA-4q9zA:
24.5		 2ivuA-4q9zA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 793
GLY A 794
VAL A 801
LYS A 821
GLU A 830
LEU A 864
 ADP  A1501 ( 3.7A)
ADP  A1501 (-3.3A)
ADP  A1501 (-3.8A)
ADP  A1501 (-2.7A)
ADP  A1501 ( 4.8A)
None
 0.31A 2ivuA-4qpmA:
21.6		 2ivuA-4qpmA:
24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
LYS A 644
GLU A 661
LEU A 689
TYR A 693
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
 0.46A 2ivuA-4rt7A:
26.2		 2ivuA-4rt7A:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
LYS A 644
LEU A 689
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.45A 2ivuA-4rt7A:
26.2		 2ivuA-4rt7A:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
GLY A  15
VAL A  22
LYS A  37
GLU A  52
TYR A  83
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.56A 2ivuA-4ueuA:
34.0		 2ivuA-4ueuA:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 151
VAL A 158
LYS A 171
LEU A 218
ALA A 223
LEU A 275
ASP A 294
 None
 0.87A 2ivuA-4uy9A:
26.2		 2ivuA-4uy9A:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
GLY A 194
LYS A 216
LEU A 239
LEU A 262
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
None
None
ANW  A 601 (-4.9A)
 0.52A 2ivuA-4wboA:
25.9		 2ivuA-4wboA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
GLY A 194
VAL A 201
LYS A 216
LEU A 239
LEU A 262
 ANW  A 601 ( 4.0A)
None
None
None
None
None
 0.36A 2ivuA-4wboA:
25.9		 2ivuA-4wboA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 473
GLY A 474
VAL A 481
LYS A 503
GLU A 520
VAL A 550
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
 0.52A 2ivuA-4xcuA:
33.3		 2ivuA-4xcuA:
52.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
GLY A 617
VAL A 624
LEU A 689
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.36A 2ivuA-4xufA:
31.5		 2ivuA-4xufA:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
LYS A 644
GLU A 661
LEU A 689
TYR A 693
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
 0.66A 2ivuA-4xufA:
31.5		 2ivuA-4xufA:
46.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
VAL A 201
LYS A 216
LEU A 239
LEU A 262
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
 0.62A 2ivuA-4yhjA:
23.4		 2ivuA-4yhjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  34
GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
None
None
None
 0.54A 2ivuA-4ysjA:
26.8		 2ivuA-4ysjA:
20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
GLY A 485
VAL A 492
GLU A 531
VAL A 561
TYR A 563
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.62A 2ivuA-5a46A:
33.2		 2ivuA-5a46A:
44.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
GLY A 485
VAL A 492
LYS A 514
GLU A 531
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.59A 2ivuA-5a46A:
33.2		 2ivuA-5a46A:
44.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY A  23
VAL A  30
LYS A  46
GLU A  63
LEU A  67
LEU A  90
TYR A  94
LEU A 145
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
GOL  A 404 ( 3.1A)
None
None
None
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.66A 2ivuA-5ci7A:
28.6		 2ivuA-5ci7A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  63
VAL A  70
LYS A  85
LEU A 130
TYR A 134
ALA A 135
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
 0.46A 2ivuA-5es1A:
24.6		 2ivuA-5es1A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
GLY A 100
VAL A 107
LYS A 122
LEU A 168
ALA A 173
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.9A)
5U5  A 401 (-4.7A)
 0.48A 2ivuA-5eykA:
26.0		 2ivuA-5eykA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
VAL A 911
LYS A 930
GLU A 947
LEU A 951
TYR A 980
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
None
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
 0.62A 2ivuA-5f1zA:
33.2		 2ivuA-5f1zA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 730
GLY A 731
VAL A 738
LYS A 758
GLU A 775
LEU A 779
LEU A 802
VAL A 804
TYR A 806
ALA A 807
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
None
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 (-4.6A)
 0.51A 2ivuA-5fm2A:
40.3		 2ivuA-5fm2A:
87.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
GLY A 600
VAL A 607
LYS A 627
GLU A 644
TYR A 676
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.0A)
 0.55A 2ivuA-5grnA:
26.4		 2ivuA-5grnA:
43.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
GLY A 600
VAL A 607
LYS A 627
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.47A 2ivuA-5grnA:
26.4		 2ivuA-5grnA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  28
VAL A  35
GLU A  66
LEU A  95
TYR A  99
ALA A 100
LEU A 158
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
FMT  A 404 ( 4.2A)
None
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
 0.70A 2ivuA-5idnA:
11.4		 2ivuA-5idnA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  35
GLU A  66
LEU A  70
LEU A  95
TYR A  99
ALA A 100
LEU A 158
 6A7  A 401 ( 4.5A)
FMT  A 404 ( 4.2A)
None
None
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
 0.74A 2ivuA-5idnA:
11.4		 2ivuA-5idnA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  45
GLY A  46
VAL A  53
LYS A  68
LEU A  85
LEU A 111
ASP A 175
 HC4  A 401 ( 4.8A)
None
None
HC4  A 401 (-2.7A)
None
None
HC4  A 401 (-4.0A)
 0.80A 2ivuA-5movA:
24.2		 2ivuA-5movA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  45
VAL A  53
LYS A  68
GLU A  81
LEU A  85
LEU A 111
ASP A 175
 HC4  A 401 ( 4.8A)
None
HC4  A 401 (-2.7A)
None
None
None
HC4  A 401 (-4.0A)
 0.92A 2ivuA-5movA:
24.2		 2ivuA-5movA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 7 LEU A  44
GLY A  45
VAL A  52
LYS A  67
GLU A  89
LEU A  93
LEU A 118
 None
None
7LK  A 401 (-4.9A)
None
None
None
None
 0.57A 2ivuA-5turA:
25.3		 2ivuA-5turA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 LEU A  17
GLY A  18
VAL A  25
LYS A  40
GLU A  59
TYR A  94
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
None
 0.53A 2ivuA-5u94A:
19.2		 2ivuA-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 8 GLY A 734
VAL A 741
LYS A 756
GLU A 774
LEU A 778
LEU A 811
TYR A 815
ASP A 877
 CJM  A1102 (-3.4A)
None
None
None
None
None
CJM  A1102 (-4.1A)
MG  A1101 (-2.5A)
 0.87A 2ivuA-6b3eA:
25.7		 2ivuA-6b3eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
GLY A 882
VAL A 889
LYS A 908
GLU A 925
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.5A)
 0.55A 2ivuA-6c7yA:
33.9		 2ivuA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 10 LEU A 730
GLY A 731
VAL A 738
GLU A 775
LEU A 779
LEU A 802
VAL A 804
TYR A 806
ALA A 807
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
None
None
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-4.3A)
 0.32A 2ivuA-6fekA:
45.5		 2ivuA-6fekA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)

(Rattus
norvegicus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ALA A 155
GLY A 216
SER A 266
 None
 0.52A 2ivuA-1bu8A:
0.0		 2ivuA-1bu8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		3 ALA A 318
GLY A 197
SER A 225
 PLP  A 955 (-3.4A)
PLP  A 955 (-3.4A)
PLP  A 955 ( 3.9A)
 0.59A 2ivuA-1c4kA:
0.0		 2ivuA-1c4kA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpc C-PHYCOCYANIN (ALPHA
SUBUNIT)
C-PHYCOCYANIN (BETA
SUBUNIT)

(Microchaete
diplosiphon;
Microchaete
diplosiphon) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		3 ALA A  41
GLY B  21
SER B  28
 None
 0.59A 2ivuA-1cpcA:
undetectable		 2ivuA-1cpcA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		3 ALA A 193
GLY A 224
SER A 185
 None
 0.46A 2ivuA-1efpA:
0.0		 2ivuA-1efpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE

(Lactobacillus
pentosus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ALA A 136
GLY A 252
SER A 259
 NAD  A1352 (-4.2A)
None
None
 0.56A 2ivuA-1ez4A:
0.0		 2ivuA-1ez4A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		3 ALA A 315
GLY A  13
SER A 296
 None
FAD  A 699 (-3.4A)
None
 0.59A 2ivuA-1fcdA:
undetectable		 2ivuA-1fcdA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ft5 CYTOCHROME C554

(Nitrosomonas
europaea) 		PF13435
(Cytochrome_C554) 		3 ALA A  30
GLY A  62
SER A  90
 HEM  A 216 (-3.9A)
None
HEM  A 216 (-3.9A)
 0.53A 2ivuA-1ft5A:
undetectable		 2ivuA-1ft5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		3 ALA A  91
GLY A 107
SER A  97
 None
 0.59A 2ivuA-1g8wA:
0.0		 2ivuA-1g8wA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE

(Saccharomyces
cerevisiae) 		PF03051
(Peptidase_C1_2) 		3 ALA A 261
GLY A 156
SER A 251
 None
 0.58A 2ivuA-1gcbA:
0.0		 2ivuA-1gcbA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpl RP2 LIPASE

(Cavia porcellus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ALA A 155
GLY A 216
SER A 266
 None
 0.45A 2ivuA-1gplA:
0.3		 2ivuA-1gplA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		3 ALA A 275
GLY A 268
SER A 259
 None
 0.59A 2ivuA-1gz5A:
0.0		 2ivuA-1gz5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		3 ALA A  44
GLY A 415
SER A 385
 None
 0.57A 2ivuA-1hqsA:
undetectable		 2ivuA-1hqsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ALA A 416
GLY A 233
SER A 396
 None
SO4  A 501 ( 3.7A)
None
 0.59A 2ivuA-1ig8A:
undetectable		 2ivuA-1ig8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ALA B 155
GLY B 216
SER B 266
 None
 0.44A 2ivuA-1lpbB:
undetectable		 2ivuA-1lpbB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 ALA A 165
GLY A 533
SER A 140
 FAD  A3000 (-3.3A)
FAD  A3000 (-3.4A)
None
 0.55A 2ivuA-1m64A:
undetectable		 2ivuA-1m64A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 ALA A 590
GLY A 795
SER A 111
 None
None
FES  A3001 ( 4.9A)
 0.59A 2ivuA-1n5xA:
undetectable		 2ivuA-1n5xA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1na6 RESTRICTION
ENDONUCLEASE ECORII

(Escherichia
coli) 		PF09019
(EcoRII-C)
PF09217
(EcoRII-N) 		3 ALA A  80
GLY A  39
SER A 106
 None
 0.58A 2ivuA-1na6A:
undetectable		 2ivuA-1na6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		3 ALA A  97
GLY A  45
SER A  57
 None
 0.59A 2ivuA-1oa1A:
undetectable		 2ivuA-1oa1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0z SENSOR KINASE CITA

(Klebsiella
pneumoniae) 		PF17203
(sCache_3_2) 		3 ALA A  87
GLY A 108
SER A  24
 None
None
NA  A1633 (-2.4A)
 0.60A 2ivuA-1p0zA:
undetectable		 2ivuA-1p0zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ALA A 392
GLY A 413
SER A 446
 None
None
TPP  A 557 ( 2.4A)
 0.38A 2ivuA-1pvdA:
undetectable		 2ivuA-1pvdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		3 ALA A 428
GLY A 248
SER A 347
 None
 0.56A 2ivuA-1q15A:
undetectable		 2ivuA-1q15A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		3 ALA A 181
GLY A 158
SER A 194
 None
 0.59A 2ivuA-1q1rA:
undetectable		 2ivuA-1q1rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		no annotation 3 ALA E 226
GLY E 264
SER E 259
 None
 0.57A 2ivuA-1qgeE:
undetectable		 2ivuA-1qgeE:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ALA A 155
GLY A 216
SER A 266
 None
 0.60A 2ivuA-1rp1A:
undetectable		 2ivuA-1rp1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 ALA A 245
GLY A 356
SER A 363
 PIM  A 431 (-3.6A)
None
None
 0.56A 2ivuA-1s1fA:
undetectable		 2ivuA-1s1fA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ALA A 509
GLY A 519
SER A 485
 None
 0.53A 2ivuA-1sb3A:
undetectable		 2ivuA-1sb3A:
17.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ALA A 389
GLY A 441
SER A 499
 None
 0.46A 2ivuA-1snxA:
22.5		 2ivuA-1snxA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ALA A 745
GLY A  79
SER A 788
 None
 0.58A 2ivuA-1tmoA:
undetectable		 2ivuA-1tmoA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ALA B  45
GLY B 224
SER B 202
 None
 0.59A 2ivuA-1tqyB:
undetectable		 2ivuA-1tqyB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		3 ALA A 505
GLY A 620
SER A 463
 None
 0.59A 2ivuA-1u2lA:
undetectable		 2ivuA-1u2lA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzj FIBRILLIN-1

(Homo sapiens) 		PF00683
(TB)
PF07645
(EGF_CA) 		3 ALA A1560
GLY A1591
SER A1499
 None
 0.53A 2ivuA-1uzjA:
undetectable		 2ivuA-1uzjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		3 ALA A  24
GLY A 160
SER A  66
 None
 0.60A 2ivuA-1v71A:
undetectable		 2ivuA-1v71A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		3 ALA A 234
GLY A 183
SER A 308
 None
PLP  A 350 (-3.3A)
PLP  A 350 (-2.8A)
 0.60A 2ivuA-1v71A:
undetectable		 2ivuA-1v71A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		3 ALA B 296
GLY B 227
SER B 371
 None
PLP  B 400 (-3.5A)
PLP  B 400 (-2.6A)
 0.51A 2ivuA-1wdwB:
undetectable		 2ivuA-1wdwB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		3 ALA A 176
GLY A  16
SER A  47
 SO4  A 501 (-3.7A)
None
None
 0.57A 2ivuA-1xviA:
undetectable		 2ivuA-1xviA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		3 ALA A  44
GLY A  35
SER A  65
 None
 0.60A 2ivuA-1ydwA:
undetectable		 2ivuA-1ydwA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN B1A CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		3 ALA C 114
GLY C 139
SER C 145
 None
 0.58A 2ivuA-1yhuC:
undetectable		 2ivuA-1yhuC:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjg SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		3 ALA A 104
GLY A  97
SER A  67
 None
 0.50A 2ivuA-1yjgA:
3.5		 2ivuA-1yjgA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym0 FIBRINOTIC ENZYME
COMPONENT B
FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida;
Eisenia fetida) 		PF00089
(Trypsin)
no annotation 		3 ALA B   9
GLY B   2
SER A 200
 None
 0.54A 2ivuA-1ym0B:
undetectable		 2ivuA-1ym0B:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii) 		PF00258
(Flavodoxin_1) 		3 ALA A 109
GLY A  53
SER A  73
 None
 0.52A 2ivuA-1yobA:
undetectable		 2ivuA-1yobA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		3 ALA A 245
GLY A 140
SER A 215
 PLP  A 434 (-3.6A)
PLP  A 434 ( 3.9A)
MES  A 435 (-3.2A)
 0.56A 2ivuA-1z3zA:
undetectable		 2ivuA-1z3zA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcm F1845 FIMBRIAL
PROTEIN

(Escherichia
coli) 		no annotation 3 ALA B  56
GLY B 109
SER B  91
 None
 0.50A 2ivuA-2bcmB:
undetectable		 2ivuA-2bcmB:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		3 ALA A 276
GLY A 269
SER A 255
 None
 0.58A 2ivuA-2eijA:
undetectable		 2ivuA-2eijA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		3 ALA A  39
GLY A 131
SER A 140
 None
 0.42A 2ivuA-2favA:
undetectable		 2ivuA-2favA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		3 ALA A1591
GLY A1766
SER A1773
 None
 0.39A 2ivuA-2fr1A:
undetectable		 2ivuA-2fr1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF02153
(PDH) 		3 ALA A 150
GLY A 195
SER A  48
 None
 0.53A 2ivuA-2g5cA:
undetectable		 2ivuA-2g5cA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga0 SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		3 ALA A 104
GLY A  97
SER A  67
 None
 0.49A 2ivuA-2ga0A:
3.4		 2ivuA-2ga0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		3 ALA A 103
GLY A 151
SER A 178
 FMN  A1904 (-3.1A)
NIS  A 500 (-2.8A)
FMN  A1904 (-3.2A)
 0.38A 2ivuA-2gjnA:
undetectable		 2ivuA-2gjnA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		3 ALA A 297
GLY A 435
SER A 171
 None
 0.59A 2ivuA-2h21A:
undetectable		 2ivuA-2h21A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 ALA A 659
GLY A 713
SER A 771
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.8A)
 0.41A 2ivuA-2henA:
24.1		 2ivuA-2henA:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iks DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		3 ALA A 217
GLY A 252
SER A 246
 None
 0.50A 2ivuA-2iksA:
undetectable		 2ivuA-2iksA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1

(Rattus
norvegicus) 		PF01161
(PBP) 		3 ALA A 171
GLY A 108
SER A 176
 None
 0.38A 2ivuA-2iqxA:
undetectable		 2ivuA-2iqxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		3 ALA A1733
GLY A1943
SER A1863
 None
 0.59A 2ivuA-2ix8A:
undetectable		 2ivuA-2ix8A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 ALA A 300
GLY A 151
SER A 193
 None
PLP  A1494 (-3.5A)
PLP  A1494 ( 4.1A)
 0.59A 2ivuA-2jisA:
undetectable		 2ivuA-2jisA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o34 HYPOTHETICAL PROTEIN

(Desulfovibrio
vulgaris) 		no annotation 3 ALA A 199
GLY A 129
SER A 165
 NA  A 501 ( 4.8A)
NA  A 503 ( 4.2A)
None
 0.58A 2ivuA-2o34A:
undetectable		 2ivuA-2o34A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ALA A 174
GLY A 234
SER A 284
 None
NA  A 480 (-4.3A)
None
 0.55A 2ivuA-2pplA:
undetectable		 2ivuA-2pplA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ALA A 155
GLY A 216
SER A 266
 None
 0.53A 2ivuA-2pvsA:
undetectable		 2ivuA-2pvsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA

(Mus musculus;
Paraburkholderia
xenovorans) 		PF01007
(IRK) 		3 ALA A 259
GLY A 163
SER A 168
 None
 0.56A 2ivuA-2qksA:
undetectable		 2ivuA-2qksA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ALA A 651
GLY A 705
SER A 763
 PTR  A 701 ( 4.7A)
None
None
 0.28A 2ivuA-2qobA:
33.4		 2ivuA-2qobA:
29.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 ALA A 705
GLY A 759
SER A 817
 None
 0.27A 2ivuA-2r2pA:
35.3		 2ivuA-2r2pA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		3 ALA A  87
GLY A 131
SER A  41
 None
 0.48A 2ivuA-2rmpA:
undetectable		 2ivuA-2rmpA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 ALA A 513
GLY A 410
SER A 469
 None
 0.57A 2ivuA-2uvfA:
undetectable		 2ivuA-2uvfA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		3 ALA A  54
GLY A  34
SER A  69
 None
KDG  A1313 ( 3.3A)
None
 0.46A 2ivuA-2varA:
undetectable		 2ivuA-2varA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ALA A 392
GLY A 413
SER A 446
 None
TPP  A 600 (-4.9A)
TPP  A 600 (-2.7A)
 0.34A 2ivuA-2vk4A:
undetectable		 2ivuA-2vk4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		3 ALA A  84
GLY A  22
SER A  55
 None
 0.55A 2ivuA-2vn7A:
undetectable		 2ivuA-2vn7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 ALA A 363
GLY A  76
SER A 200
 ADP  A1490 (-3.5A)
ADP  A1490 (-3.1A)
None
 0.55A 2ivuA-2vosA:
undetectable		 2ivuA-2vosA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vri NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
NL63) 		PF01661
(Macro) 		3 ALA A  31
GLY A 121
SER A 130
 None
 0.38A 2ivuA-2vriA:
undetectable		 2ivuA-2vriA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		3 ALA A 134
GLY A 103
SER A  53
 NDP  A1169 ( 3.8A)
NDP  A1169 ( 3.8A)
NDP  A1169 ( 3.9A)
 0.53A 2ivuA-2w3wA:
undetectable		 2ivuA-2w3wA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5o ALPHA-L-ARABINOFURAN
OSIDASE

(Fusarium
graminearum) 		no annotation 3 ALA A 287
GLY A 246
SER A 253
 None
 0.55A 2ivuA-2w5oA:
2.5		 2ivuA-2w5oA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		3 ALA A 110
GLY A  54
SER A  74
 None
 0.59A 2ivuA-2wc1A:
undetectable		 2ivuA-2wc1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE

(Lactococcus
lactis) 		PF13419
(HAD_2) 		3 ALA A 113
GLY A 174
SER A 181
 None
 0.49A 2ivuA-2wf7A:
undetectable		 2ivuA-2wf7A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwv N,N'-DIACETYLCHITOBI
OSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT

(Escherichia
coli) 		PF02255
(PTS_IIA) 		3 ALA A  87
GLY A  16
SER A  44
 None
 0.59A 2ivuA-2wwvA:
undetectable		 2ivuA-2wwvA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqr INVERTASE INHIBITOR

(Nicotiana
tabacum) 		PF04043
(PMEI) 		3 ALA B  88
GLY B 139
SER B 107
 None
 0.58A 2ivuA-2xqrB:
2.3		 2ivuA-2xqrB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		3 ALA A 156
GLY A 183
SER A 199
 None
 0.59A 2ivuA-2xwgA:
undetectable		 2ivuA-2xwgA:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 ALA A 651
GLY A 705
SER A 763
 Q9G  A1898 (-3.2A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-3.2A)
 0.16A 2ivuA-2xyuA:
27.4		 2ivuA-2xyuA:
34.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		3 ALA D 133
GLY D 173
SER D  22
 None
 0.56A 2ivuA-2ynmD:
undetectable		 2ivuA-2ynmD:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		3 ALA A 223
GLY A  86
SER A 135
 PLP  A 501 (-3.4A)
PLP  A 501 ( 4.8A)
PLP  A 501 ( 3.7A)
 0.58A 2ivuA-3a9xA:
undetectable		 2ivuA-3a9xA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		3 ALA A  95
GLY A  46
SER A  61
 None
 0.56A 2ivuA-3abzA:
undetectable		 2ivuA-3abzA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		3 ALA A 165
GLY A 255
SER A 299
 None
 0.51A 2ivuA-3agrA:
undetectable		 2ivuA-3agrA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		3 ALA A 165
GLY A 304
SER A 299
 None
 0.60A 2ivuA-3agrA:
undetectable		 2ivuA-3agrA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		3 ALA A 554
GLY A 267
SER A 692
 None
 0.50A 2ivuA-3aqpA:
2.0		 2ivuA-3aqpA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ALA A 487
GLY A 443
SER A 458
 None
SF4  A 602 ( 4.3A)
None
 0.60A 2ivuA-3b0hA:
undetectable		 2ivuA-3b0hA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0p TRNA-DIHYDROURIDINE
SYNTHASE

(Thermus
thermophilus) 		PF01207
(Dus) 		3 ALA A  65
GLY A 101
SER A  95
 None
 0.54A 2ivuA-3b0pA:
3.9		 2ivuA-3b0pA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bew MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B21

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ALA A 201
GLY A 266
SER A 261
 None
 0.60A 2ivuA-3bewA:
undetectable		 2ivuA-3bewA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF13085
(Fer2_3)
PF13183
(Fer4_8) 		3 ALA B 115
GLY B 169
SER B 197
 None
 0.54A 2ivuA-3cirB:
undetectable		 2ivuA-3cirB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		3 ALA A 271
GLY A  64
SER A  87
 None
 0.59A 2ivuA-3egjA:
undetectable		 2ivuA-3egjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejf NON-STRUCTURAL
PROTEIN 3

(Avian
coronavirus) 		PF01661
(Macro) 		3 ALA A  38
GLY A 130
SER A 139
 None
 0.45A 2ivuA-3ejfA:
undetectable		 2ivuA-3ejfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		3 ALA A  34
GLY A 124
SER A 133
 None
 0.57A 2ivuA-3ejgA:
undetectable		 2ivuA-3ejgA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		3 ALA P 174
GLY P 151
SER P 187
 None
 0.57A 2ivuA-3fg2P:
undetectable		 2ivuA-3fg2P:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		3 ALA A 178
GLY A  35
SER A  67
 None
FAD  A1000 (-3.3A)
FAD  A1000 (-2.9A)
 0.57A 2ivuA-3gyxA:
undetectable		 2ivuA-3gyxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		3 ALA A 228
GLY A 193
SER A 196
 None
 0.59A 2ivuA-3h5tA:
undetectable		 2ivuA-3h5tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		3 ALA A1587
GLY A1028
SER A1218
 None
 0.50A 2ivuA-3hmjA:
undetectable		 2ivuA-3hmjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqf RESTRICTION
ENDONUCLEASE

(Escherichia
coli) 		PF09217
(EcoRII-N) 		3 ALA A  80
GLY A  39
SER A 106
 None
 0.60A 2ivuA-3hqfA:
undetectable		 2ivuA-3hqfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri;
Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF02738
(Ald_Xan_dh_C2) 		3 ALA A 308
GLY B 247
SER A  44
 None
 0.56A 2ivuA-3hrdA:
undetectable		 2ivuA-3hrdA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		3 ALA A 183
GLY A 190
SER A 150
 NAD  A 401 (-3.3A)
None
None
 0.55A 2ivuA-3i0pA:
undetectable		 2ivuA-3i0pA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		3 ALA 1 406
GLY 1 362
SER 1 398
 None
None
SF4  1 439 ( 4.5A)
 0.58A 2ivuA-3i9v1:
undetectable		 2ivuA-3i9v1:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		3 ALA A 268
GLY A 217
SER A 344
 None
LLP  A  91 ( 3.4A)
LLP  A  91 ( 2.7A)
 0.54A 2ivuA-3iauA:
undetectable		 2ivuA-3iauA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ALA A 191
GLY A 197
SER A 204
 None
 0.59A 2ivuA-3iwaA:
undetectable		 2ivuA-3iwaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		3 ALA B 501
GLY B 620
SER B 627
 None
 0.59A 2ivuA-3jb9B:
undetectable		 2ivuA-3jb9B:
16.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 ALA A 665
GLY A 719
SER A 777
 None
GOL  A 403 (-3.4A)
None
 0.53A 2ivuA-3kulA:
35.6		 2ivuA-3kulA:
31.36