SIMILAR PATTERNS OF AMINO ACIDS FOR 2ITZ_A_IREA2021_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		3 LEU A 330
LEU A 307
MET A 302
 None
 0.87A 2itzA-12asA:
undetectable		 2itzA-12asA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by4 PROTEIN (RETINOIC
ACID RECEPTOR
RXR-ALPHA)

(Homo sapiens) 		PF00105
(zf-C4) 		3 LEU A1167
LEU A1196
MET A1200
 None
 0.75A 2itzA-1by4A:
undetectable		 2itzA-1by4A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 LEU A  96
LEU A  45
MET A  44
 None
 0.76A 2itzA-1c7tA:
undetectable		 2itzA-1c7tA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4b HUMAN CELL
DEATH-INDUCING
EFFECTOR B

(Homo sapiens) 		PF02017
(CIDE-N) 		3 LEU A  92
LEU A  99
MET A 100
 None
 0.87A 2itzA-1d4bA:
undetectable		 2itzA-1d4bA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		3 LEU A 295
LEU A 278
MET A 277
 None
 0.77A 2itzA-1flcA:
undetectable		 2itzA-1flcA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LEU A 157
LEU A 132
MET A 133
 None
 0.87A 2itzA-1fn4A:
undetectable		 2itzA-1fn4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		3 LEU A 259
LEU A 347
MET A 348
 None
 0.71A 2itzA-1jeqA:
2.5		 2itzA-1jeqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 LEU A 447
LEU A 540
MET A 539
 None
 0.84A 2itzA-1pvdA:
undetectable		 2itzA-1pvdA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		3 LEU A  54
LEU A 111
MET A 110
 None
 0.83A 2itzA-1q3bA:
undetectable		 2itzA-1q3bA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		3 LEU A 505
LEU A 585
MET A 586
 None
 0.86A 2itzA-1q3xA:
undetectable		 2itzA-1q3xA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry9 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK

(Shigella
flexneri) 		PF03519
(Invas_SpaK) 		3 LEU A  88
LEU A  54
MET A  53
 None
 0.55A 2itzA-1ry9A:
undetectable		 2itzA-1ry9A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tht THIOESTERASE

(Vibrio harveyi) 		PF02273
(Acyl_transf_2) 		3 LEU A 141
LEU A 193
MET A 222
 None
 0.65A 2itzA-1thtA:
undetectable		 2itzA-1thtA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj6 SPRED1

(Xenopus
tropicalis) 		PF00568
(WH1) 		3 LEU A  62
LEU A  31
MET A  19
 None
 0.72A 2itzA-1tj6A:
undetectable		 2itzA-1tj6A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa4 PCZA361.16

(Amycolatopsis
orientalis) 		PF00908
(dTDP_sugar_isom) 		3 LEU A 156
LEU A 103
MET A 104
 None
 0.70A 2itzA-1wa4A:
undetectable		 2itzA-1wa4A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xn8 HYPOTHETICAL PROTEIN
YQBG

(Bacillus
subtilis) 		PF11436
(DUF3199) 		3 LEU A  39
LEU A   2
MET A   1
 None
 0.83A 2itzA-1xn8A:
undetectable		 2itzA-1xn8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvs PROTEIN APAG

(Vibrio cholerae) 		PF04379
(DUF525) 		3 LEU A   5
LEU A  46
MET A  47
 None
 0.84A 2itzA-1xvsA:
undetectable		 2itzA-1xvsA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		3 LEU A 159
LEU A  90
MET A  91
 None
 0.80A 2itzA-1ygpA:
undetectable		 2itzA-1ygpA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		3 LEU A 273
LEU A 318
MET A 317
 None
 0.73A 2itzA-1yw6A:
undetectable		 2itzA-1yw6A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		3 LEU A 505
LEU A 585
MET A 586
 None
 0.86A 2itzA-1zjkA:
undetectable		 2itzA-1zjkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Homo sapiens) 		PF00551
(Formyl_trans_N) 		3 LEU A  14
LEU A 105
MET A 104
 None
 0.82A 2itzA-1zlyA:
undetectable		 2itzA-1zlyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 144
LEU A 148
MET A 149
 AIZ  A 501 (-4.2A)
AIZ  A 501 ( 4.7A)
None
 0.42A 2itzA-2b1pA:
19.5		 2itzA-2b1pA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		3 LEU A 138
LEU A  69
MET A  70
 None
 0.79A 2itzA-2c4mA:
undetectable		 2itzA-2c4mA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2col BIFUNCTIONAL
HEMOLYSIN-ADENYLATE
CYCLASE

(Bordetella
pertussis) 		PF03497
(Anthrax_toxA) 		3 LEU A  38
LEU A 325
MET A 324
 None
 0.74A 2itzA-2colA:
undetectable		 2itzA-2colA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4p HYPOTHETICAL PROTEIN
TM1010

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		3 LEU A  60
LEU A  26
MET A  25
 None
 0.79A 2itzA-2f4pA:
undetectable		 2itzA-2f4pA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		3 LEU A 171
LEU A 143
MET A 142
 None
 0.63A 2itzA-2hmaA:
undetectable		 2itzA-2hmaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sinapis alba) 		PF00348
(polyprenyl_synt) 		3 LEU A 133
LEU A 125
MET A  87
 None
 0.71A 2itzA-2j1oA:
undetectable		 2itzA-2j1oA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 LEU A 236
LEU A 290
MET A 275
 None
 0.79A 2itzA-2ph5A:
undetectable		 2itzA-2ph5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		3 LEU A 101
LEU A 105
MET A 106
 None
 0.63A 2itzA-2phkA:
23.3		 2itzA-2phkA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME

(Burkholderia
pseudomallei) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 328
LEU A 292
MET A 291
 None
None
NA  A 409 ( 4.6A)
 0.86A 2itzA-2podA:
undetectable		 2itzA-2podA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh9 UPF0215 PROTEIN
AF_1433

(Archaeoglobus
fulgidus) 		PF01949
(DUF99) 		3 LEU A  72
LEU A 111
MET A 108
 None
 0.81A 2itzA-2qh9A:
undetectable		 2itzA-2qh9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		3 LEU A 441
LEU A 464
MET A 578
 None
 0.86A 2itzA-2qqmA:
undetectable		 2itzA-2qqmA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A 794
LEU A 798
MET A 799
 GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
None
 0.48A 2itzA-2r4bA:
32.5		 2itzA-2r4bA:
78.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vri NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
NL63) 		PF01661
(Macro) 		3 LEU A  49
LEU A  76
MET A  75
 None
 0.56A 2itzA-2vriA:
undetectable		 2itzA-2vriA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 487
LEU A 491
MET A 492
 None
 0.32A 2itzA-2wntA:
20.4		 2itzA-2wntA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 LEU A 515
LEU A 452
MET A 420
 None
 0.49A 2itzA-2xn1A:
undetectable		 2itzA-2xn1A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE

(Rhodothermus
marinus) 		no annotation 3 LEU A  33
LEU A 168
MET A 169
 None
 0.70A 2itzA-2y4lA:
undetectable		 2itzA-2y4lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6g XYLANASE

(Rhodothermus
marinus) 		PF02018
(CBM_4_9) 		3 LEU A 167
LEU A   2
MET A   1
 None
 0.62A 2itzA-2y6gA:
undetectable		 2itzA-2y6gA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 105
LEU A 109
MET A 110
 None
B49  A1294 ( 4.7A)
None
 0.35A 2itzA-2y7jA:
24.4		 2itzA-2y7jA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		3 LEU A 604
LEU A 405
MET A 404
 None
 0.81A 2itzA-3biwA:
undetectable		 2itzA-3biwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		3 LEU A 651
LEU A 690
MET A 691
 None
 0.86A 2itzA-3bjcA:
undetectable		 2itzA-3bjcA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		3 LEU A 303
LEU A 206
MET A 207
 None
 0.86A 2itzA-3breA:
undetectable		 2itzA-3breA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8k PROTEIN PHOSPHATASE
2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		3 LEU A 218
LEU A 222
MET A 223
 None
 0.71A 2itzA-3d8kA:
undetectable		 2itzA-3d8kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 195
LEU A 227
MET A 203
 None
 0.78A 2itzA-3ddmA:
undetectable		 2itzA-3ddmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 332
LEU A 292
MET A 291
 None
 0.84A 2itzA-3dipA:
undetectable		 2itzA-3dipA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 106
LEU A 110
MET A 111
 None
35F  A   1 (-4.5A)
None
 0.52A 2itzA-3e7oA:
20.7		 2itzA-3e7oA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK

(Escherichia
coli) 		PF00106
(adh_short) 		3 LEU A  97
LEU A 179
MET A 176
 None
 0.81A 2itzA-3f1kA:
undetectable		 2itzA-3f1kA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 3 LEU A 718
LEU A 642
MET A 646
 None
 0.83A 2itzA-3f95A:
undetectable		 2itzA-3f95A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21

(Homo sapiens) 		PF00443
(UCH) 		3 LEU A 553
LEU A 557
MET A 558
 None
 0.80A 2itzA-3i3tA:
undetectable		 2itzA-3i3tA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5b WSPR RESPONSE
REGULATOR

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		3 LEU A 303
LEU A 206
MET A 207
 None
 0.84A 2itzA-3i5bA:
undetectable		 2itzA-3i5bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		3 LEU A  97
LEU A 179
MET A 176
 None
 0.85A 2itzA-3iahA:
undetectable		 2itzA-3iahA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 3 LEU A  99
LEU A  72
MET A  73
 None
 0.76A 2itzA-3ixlA:
undetectable		 2itzA-3ixlA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		3 LEU A 649
LEU A 405
MET A 404
 None
 0.76A 2itzA-3j4pA:
undetectable		 2itzA-3j4pA:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A 764
LEU A 768
MET A 769
 ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
 0.62A 2itzA-3lzbA:
34.3		 2itzA-3lzbA:
87.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LEU A 237
LEU A 223
MET A 222
 4AD  A 500 (-4.4A)
None
None
 0.87A 2itzA-3m4pA:
undetectable		 2itzA-3m4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 LEU A 304
LEU A 218
MET A 217
 None
 0.74A 2itzA-3moiA:
undetectable		 2itzA-3moiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)

(Archaeoglobus
fulgidus) 		PF12804
(NTP_transf_3) 		3 LEU A  33
LEU A  23
MET A  22
 None
 0.86A 2itzA-3ngwA:
undetectable		 2itzA-3ngwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LEU A 261
LEU A 265
MET A 266
 None
AMP  A 577 ( 4.9A)
None
 0.44A 2itzA-3nyoA:
19.9		 2itzA-3nyoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of6 PRE T-CELL ANTIGEN
RECEPTOR ALPHA

(Homo sapiens) 		PF15028
(PTCRA) 		3 LEU D  76
LEU D  19
MET D  18
 None
 0.83A 2itzA-3of6D:
undetectable		 2itzA-3of6D:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		3 LEU A 105
LEU A 109
MET A 110
 1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
None
 0.43A 2itzA-3ohtA:
16.6		 2itzA-3ohtA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		3 LEU A 146
LEU A 323
MET A 294
 None
 0.60A 2itzA-3oqbA:
undetectable		 2itzA-3oqbA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		3 LEU A 290
LEU A 323
MET A 294
 None
 0.83A 2itzA-3oqbA:
undetectable		 2itzA-3oqbA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		3 LEU A 110
LEU A 114
MET A 115
 None
 0.82A 2itzA-3pg1A:
20.4		 2itzA-3pg1A:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A 796
LEU A 800
MET A 801
 03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
 0.41A 2itzA-3pp0A:
36.9		 2itzA-3pp0A:
78.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 LEU A 581
LEU A 296
MET A 649
 None
UDP  A 901 (-3.7A)
None
 0.77A 2itzA-3s29A:
undetectable		 2itzA-3s29A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syx SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00568
(WH1) 		3 LEU A  65
LEU A  34
MET A  22
 None
 0.77A 2itzA-3syxA:
undetectable		 2itzA-3syxA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3a KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY B MEMBER
1A

(Mus musculus) 		PF00059
(Lectin_C) 		3 LEU A 214
LEU A 131
MET A 130
 None
 0.80A 2itzA-3t3aA:
undetectable		 2itzA-3t3aA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli) 		PF02016
(Peptidase_S66) 		3 LEU A 273
LEU A 316
MET A 315
 EDO  A 347 ( 4.3A)
None
None
 0.81A 2itzA-3tlzA:
undetectable		 2itzA-3tlzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tuo DNA-BINDING PROTEIN
SATB1

(Homo sapiens) 		PF16534
(ULD) 		3 LEU A 106
LEU A  74
MET A  73
 None
 0.81A 2itzA-3tuoA:
undetectable		 2itzA-3tuoA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u50 TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		PF08646
(Rep_fac-A_C) 		3 LEU C 673
LEU C 587
MET C 586
 None
 0.87A 2itzA-3u50C:
undetectable		 2itzA-3u50C:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ul3 THIOREDOXIN

(Plasmodium
falciparum) 		no annotation 3 LEU B 106
LEU B 137
MET B 136
 None
 0.83A 2itzA-3ul3B:
undetectable		 2itzA-3ul3B:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Burkholderia
ambifaria) 		no annotation 3 LEU A 245
LEU A 230
MET A 229
 None
 0.85A 2itzA-3w21A:
undetectable		 2itzA-3w21A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjj TRANSCRIPTION FACTOR
TAU SUBUNIT SFC1
TRANSCRIPTION FACTOR
TAU SUBUNIT SFC7

(Schizosaccharomyces
pombe) 		PF09734
(Tau95)
PF10419
(TFIIIC_sub6) 		3 LEU A  77
LEU B  90
MET B  89
 None
 0.85A 2itzA-4bjjA:
undetectable		 2itzA-4bjjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 LEU A 133
LEU A 104
MET A 105
 None
 0.83A 2itzA-4c7oA:
undetectable		 2itzA-4c7oA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 LEU A  97
LEU A 257
MET A 256
 None
 0.75A 2itzA-4e1lA:
undetectable		 2itzA-4e1lA:
24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 LEU A 606
LEU A 653
MET A 652
 None
None
0T8  A 901 (-3.9A)
 0.75A 2itzA-4feqA:
25.4		 2itzA-4feqA:
34.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		3 LEU A 239
LEU A 228
MET A 277
 None
None
HEM  A 401 ( 3.8A)
 0.83A 2itzA-4gu7A:
undetectable		 2itzA-4gu7A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1t RNA-DIRECTED RNA
POLYMERASE L

(Cali
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		3 LEU A 100
LEU A 125
MET A 123
 None
 0.75A 2itzA-4i1tA:
undetectable		 2itzA-4i1tA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 3 LEU A  54
LEU A 260
MET A 259
 None
 0.47A 2itzA-4i4nA:
undetectable		 2itzA-4i4nA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		3 LEU A 524
LEU A 601
MET A 602
 None
 0.83A 2itzA-4igdA:
undetectable		 2itzA-4igdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 3 LEU B 371
LEU B 421
MET B 422
 None
 0.87A 2itzA-4iglB:
undetectable		 2itzA-4iglB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA

(Cryphonectria
parasitica) 		PF00071
(Ras) 		3 LEU A 136
LEU A  17
MET A  16
 None
 0.76A 2itzA-4ku4A:
undetectable		 2itzA-4ku4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		3 LEU A 127
LEU A  23
MET A  20
 None
 0.73A 2itzA-4lobA:
undetectable		 2itzA-4lobA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnd CTP
L-MYO-INOSITOL-1-PHO
SPHATE
CYTIDYLYLTRANSFERASE
/CDP-L-MYO-INOSITOL
MYO-INOSITOLPHOSPHOT
RANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf)
PF12804
(NTP_transf_3) 		3 LEU A 108
LEU A  72
MET A  73
 None
 0.84A 2itzA-4mndA:
undetectable		 2itzA-4mndA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okq HUT OPERON POSITIVE
REGULATORY PROTEIN

(Geobacillus
thermodenitrificans) 		PF09021
(HutP) 		3 LEU A 137
LEU A  94
MET A  46
 None
 0.83A 2itzA-4okqA:
undetectable		 2itzA-4okqA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 LEU A  70
LEU A  62
MET A 410
 None
 0.79A 2itzA-4p22A:
undetectable		 2itzA-4p22A:
23.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 299
LEU A 303
MET A 304
 None
 0.41A 2itzA-4pwnA:
16.7		 2itzA-4pwnA:
30.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2j DNA-BINDING PROTEIN
SATB1

(Mus musculus) 		PF16534
(ULD)
PF16557
(CUTL) 		3 LEU A 106
LEU A  74
MET A  73
 None
 0.76A 2itzA-4q2jA:
undetectable		 2itzA-4q2jA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		3 LEU A 341
LEU A 333
MET A 228
 None
None
4VP  A 601 ( 3.7A)
 0.62A 2itzA-4s13A:
undetectable		 2itzA-4s13A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		3 LEU B 104
LEU B 108
MET B 109
 39G  B 401 ( 4.7A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.51A 2itzA-4tyhB:
21.7		 2itzA-4tyhB:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ure CYCLOHEXANOL
DEHYDROGENASE

(Aromatoleum
aromaticum) 		PF13561
(adh_short_C2) 		3 LEU A  23
LEU A   2
MET A   1
 None
 0.70A 2itzA-4ureA:
undetectable		 2itzA-4ureA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 3 LEU A 454
LEU A 449
MET A 448
 None
 0.87A 2itzA-4xhpA:
undetectable		 2itzA-4xhpA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 LEU A 113
LEU A  92
MET A  91
 None
 0.77A 2itzA-4z0mA:
undetectable		 2itzA-4z0mA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 LEU A 117
LEU A  92
MET A  91
 None
 0.84A 2itzA-4z0mA:
undetectable		 2itzA-4z0mA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		3 LEU A 971
LEU A 946
MET A 872
 None
 0.80A 2itzA-5a01A:
undetectable		 2itzA-5a01A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		3 LEU C  86
LEU C  89
MET C  90
 None
 0.86A 2itzA-5a53C:
undetectable		 2itzA-5a53C:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		3 LEU A 104
LEU A 108
MET A 109
 None
ANP  A 401 ( 4.8A)
None
 0.41A 2itzA-5awmA:
20.1		 2itzA-5awmA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		3 LEU A 132
LEU A 124
MET A  86
 None
 0.54A 2itzA-5e8lA:
undetectable		 2itzA-5e8lA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		3 LEU A 164
LEU A  97
MET A  98
 None
 0.75A 2itzA-5gooA:
undetectable		 2itzA-5gooA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		3 LEU A 166
LEU A 171
MET A 172
 None
 0.83A 2itzA-5hp5A:
undetectable		 2itzA-5hp5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		3 LEU A 243
LEU A 198
MET A 197
 None
 0.86A 2itzA-5ikpA:
undetectable		 2itzA-5ikpA:
16.96