SIMILAR PATTERNS OF AMINO ACIDS FOR 2ITZ_A_IREA2021_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 12as | ASPARAGINESYNTHETASE (Escherichiacoli) |
PF03590(AsnA) | 3 | LEU A 330LEU A 307MET A 302 | None | 0.87A | 2itzA-12asA:undetectable | 2itzA-12asA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1by4 | PROTEIN (RETINOICACID RECEPTORRXR-ALPHA) (Homo sapiens) |
PF00105(zf-C4) | 3 | LEU A1167LEU A1196MET A1200 | None | 0.75A | 2itzA-1by4A:undetectable | 2itzA-1by4A:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7t | BETA-N-ACETYLHEXOSAMINIDASE (Serratiamarcescens) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b)PF03173(CHB_HEX)PF03174(CHB_HEX_C) | 3 | LEU A 96LEU A 45MET A 44 | None | 0.76A | 2itzA-1c7tA:undetectable | 2itzA-1c7tA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d4b | HUMAN CELLDEATH-INDUCINGEFFECTOR B (Homo sapiens) |
PF02017(CIDE-N) | 3 | LEU A 92LEU A 99MET A 100 | None | 0.87A | 2itzA-1d4bA:undetectable | 2itzA-1d4bA:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1flc | HAEMAGGLUTININ-ESTERASE-FUSIONGLYCOPROTEIN (Influenza Cvirus) |
PF02710(Hema_HEFG)PF03996(Hema_esterase) | 3 | LEU A 295LEU A 278MET A 277 | None | 0.77A | 2itzA-1flcA:undetectable | 2itzA-1flcA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fn4 | MONOCLONAL ANTIBODYAGAINSTACETYLCHOLINERECEPTOR (Rattusnorvegicus) |
PF07654(C1-set)PF07686(V-set) | 3 | LEU A 157LEU A 132MET A 133 | None | 0.87A | 2itzA-1fn4A:undetectable | 2itzA-1fn4A:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jeq | KU70 (Homo sapiens) |
PF02037(SAP)PF02735(Ku)PF03730(Ku_C)PF03731(Ku_N) | 3 | LEU A 259LEU A 347MET A 348 | None | 0.71A | 2itzA-1jeqA:2.5 | 2itzA-1jeqA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pvd | PYRUVATEDECARBOXYLASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 3 | LEU A 447LEU A 540MET A 539 | None | 0.84A | 2itzA-1pvdA:undetectable | 2itzA-1pvdA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3b | ENDONUCLEASE VIII (Escherichiacoli) |
PF01149(Fapy_DNA_glyco)PF06827(zf-FPG_IleRS)PF06831(H2TH) | 3 | LEU A 54LEU A 111MET A 110 | None | 0.83A | 2itzA-1q3bA:undetectable | 2itzA-1q3bA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3x | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 3 | LEU A 505LEU A 585MET A 586 | None | 0.86A | 2itzA-1q3xA:undetectable | 2itzA-1q3xA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ry9 | SURFACE PRESENTATIONOF ANTIGENS PROTEINSPAK (Shigellaflexneri) |
PF03519(Invas_SpaK) | 3 | LEU A 88LEU A 54MET A 53 | None | 0.55A | 2itzA-1ry9A:undetectable | 2itzA-1ry9A:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tht | THIOESTERASE (Vibrio harveyi) |
PF02273(Acyl_transf_2) | 3 | LEU A 141LEU A 193MET A 222 | None | 0.65A | 2itzA-1thtA:undetectable | 2itzA-1thtA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tj6 | SPRED1 (Xenopustropicalis) |
PF00568(WH1) | 3 | LEU A 62LEU A 31MET A 19 | None | 0.72A | 2itzA-1tj6A:undetectable | 2itzA-1tj6A:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wa4 | PCZA361.16 (Amycolatopsisorientalis) |
PF00908(dTDP_sugar_isom) | 3 | LEU A 156LEU A 103MET A 104 | None | 0.70A | 2itzA-1wa4A:undetectable | 2itzA-1wa4A:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xn8 | HYPOTHETICAL PROTEINYQBG (Bacillussubtilis) |
PF11436(DUF3199) | 3 | LEU A 39LEU A 2MET A 1 | None | 0.83A | 2itzA-1xn8A:undetectable | 2itzA-1xn8A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xvs | PROTEIN APAG (Vibrio cholerae) |
PF04379(DUF525) | 3 | LEU A 5LEU A 46MET A 47 | None | 0.84A | 2itzA-1xvsA:undetectable | 2itzA-1xvsA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ygp | YEAST GLYCOGENPHOSPHORYLASE (Saccharomycescerevisiae) |
PF00343(Phosphorylase) | 3 | LEU A 159LEU A 90MET A 91 | None | 0.80A | 2itzA-1ygpA:undetectable | 2itzA-1ygpA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yw6 | SUCCINYLGLUTAMATEDESUCCINYLASE (Escherichiacoli) |
PF04952(AstE_AspA) | 3 | LEU A 273LEU A 318MET A 317 | None | 0.73A | 2itzA-1yw6A:undetectable | 2itzA-1yw6A:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjk | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 3 | LEU A 505LEU A 585MET A 586 | None | 0.86A | 2itzA-1zjkA:undetectable | 2itzA-1zjkA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zly | PHOSPHORIBOSYLGLYCINAMIDEFORMYLTRANSFERASE (Homo sapiens) |
PF00551(Formyl_trans_N) | 3 | LEU A 14LEU A 105MET A 104 | None | 0.82A | 2itzA-1zlyA:undetectable | 2itzA-1zlyA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b1p | MITOGEN-ACTIVATEDPROTEIN KINASE 10 (Homo sapiens) |
PF00069(Pkinase) | 3 | LEU A 144LEU A 148MET A 149 | AIZ A 501 (-4.2A)AIZ A 501 ( 4.7A)None | 0.42A | 2itzA-2b1pA:19.5 | 2itzA-2b1pA:24.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c4m | GLYCOGENPHOSPHORYLASE (Corynebacteriumcallunae) |
PF00343(Phosphorylase) | 3 | LEU A 138LEU A 69MET A 70 | None | 0.79A | 2itzA-2c4mA:undetectable | 2itzA-2c4mA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2col | BIFUNCTIONALHEMOLYSIN-ADENYLATECYCLASE (Bordetellapertussis) |
PF03497(Anthrax_toxA) | 3 | LEU A 38LEU A 325MET A 324 | None | 0.74A | 2itzA-2colA:undetectable | 2itzA-2colA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f4p | HYPOTHETICAL PROTEINTM1010 (Thermotogamaritima) |
PF07883(Cupin_2) | 3 | LEU A 60LEU A 26MET A 25 | None | 0.79A | 2itzA-2f4pA:undetectable | 2itzA-2f4pA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hma | PROBABLE TRNA(5-METHYLAMINOMETHYL-2-THIOURIDYLATE)-METHYLTRANSFERASE (Streptococcuspneumoniae) |
PF03054(tRNA_Me_trans) | 3 | LEU A 171LEU A 143MET A 142 | None | 0.63A | 2itzA-2hmaA:undetectable | 2itzA-2hmaA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j1o | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Sinapis alba) |
PF00348(polyprenyl_synt) | 3 | LEU A 133LEU A 125MET A 87 | None | 0.71A | 2itzA-2j1oA:undetectable | 2itzA-2j1oA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph5 | HOMOSPERMIDINESYNTHASE (Legionellapneumophila) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 3 | LEU A 236LEU A 290MET A 275 | None | 0.79A | 2itzA-2ph5A:undetectable | 2itzA-2ph5A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2phk | PHOSPHORYLASE KINASE (Oryctolaguscuniculus) |
PF00069(Pkinase) | 3 | LEU A 101LEU A 105MET A 106 | None | 0.63A | 2itzA-2phkA:23.3 | 2itzA-2phkA:26.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pod | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME (Burkholderiapseudomallei) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | LEU A 328LEU A 292MET A 291 | NoneNone NA A 409 ( 4.6A) | 0.86A | 2itzA-2podA:undetectable | 2itzA-2podA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qh9 | UPF0215 PROTEINAF_1433 (Archaeoglobusfulgidus) |
PF01949(DUF99) | 3 | LEU A 72LEU A 111MET A 108 | None | 0.81A | 2itzA-2qh9A:undetectable | 2itzA-2qh9A:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqm | NEUROPILIN-1 (Homo sapiens) |
PF00431(CUB)PF00754(F5_F8_type_C) | 3 | LEU A 441LEU A 464MET A 578 | None | 0.86A | 2itzA-2qqmA:undetectable | 2itzA-2qqmA:21.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r4b | RECEPTORTYROSINE-PROTEINKINASE ERBB-4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | LEU A 794LEU A 798MET A 799 | GW7 A 1 (-4.1A)GW7 A 1 (-4.5A)None | 0.48A | 2itzA-2r4bA:32.5 | 2itzA-2r4bA:78.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vri | NON-STRUCTURALPROTEIN 3 (HumancoronavirusNL63) |
PF01661(Macro) | 3 | LEU A 49LEU A 76MET A 75 | None | 0.56A | 2itzA-2vriA:undetectable | 2itzA-2vriA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wnt | RIBOSOMAL PROTEIN S6KINASE (Homo sapiens) |
PF00069(Pkinase) | 3 | LEU A 487LEU A 491MET A 492 | None | 0.32A | 2itzA-2wntA:20.4 | 2itzA-2wntA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn1 | ALPHA-GALACTOSIDASE (Lactobacillusacidophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 3 | LEU A 515LEU A 452MET A 420 | None | 0.49A | 2itzA-2xn1A:undetectable | 2itzA-2xn1A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y4l | MANNOSYLGLYCERATESYNTHASE (Rhodothermusmarinus) |
no annotation | 3 | LEU A 33LEU A 168MET A 169 | None | 0.70A | 2itzA-2y4lA:undetectable | 2itzA-2y4lA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6g | XYLANASE (Rhodothermusmarinus) |
PF02018(CBM_4_9) | 3 | LEU A 167LEU A 2MET A 1 | None | 0.62A | 2itzA-2y6gA:undetectable | 2itzA-2y6gA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7j | PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM (Homo sapiens) |
PF00069(Pkinase) | 3 | LEU A 105LEU A 109MET A 110 | NoneB49 A1294 ( 4.7A)None | 0.35A | 2itzA-2y7jA:24.4 | 2itzA-2y7jA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3biw | NEUROLIGIN-1 (Rattusnorvegicus) |
PF00135(COesterase) | 3 | LEU A 604LEU A 405MET A 404 | None | 0.81A | 2itzA-3biwA:undetectable | 2itzA-3biwA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjc | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I) | 3 | LEU A 651LEU A 690MET A 691 | None | 0.86A | 2itzA-3bjcA:undetectable | 2itzA-3bjcA:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bre | PROBABLETWO-COMPONENTRESPONSE REGULATOR (Pseudomonasaeruginosa) |
PF00072(Response_reg)PF00990(GGDEF) | 3 | LEU A 303LEU A 206MET A 207 | None | 0.86A | 2itzA-3breA:undetectable | 2itzA-3breA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8k | PROTEIN PHOSPHATASE2C (Toxoplasmagondii) |
PF00481(PP2C) | 3 | LEU A 218LEU A 222MET A 223 | None | 0.71A | 2itzA-3d8kA:undetectable | 2itzA-3d8kA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddm | PUTATIVE MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Bordetellabronchiseptica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | LEU A 195LEU A 227MET A 203 | None | 0.78A | 2itzA-3ddmA:undetectable | 2itzA-3ddmA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dip | ENOLASE (unidentified) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | LEU A 332LEU A 292MET A 291 | None | 0.84A | 2itzA-3dipA:undetectable | 2itzA-3dipA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7o | MITOGEN-ACTIVATEDPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 3 | LEU A 106LEU A 110MET A 111 | None35F A 1 (-4.5A)None | 0.52A | 2itzA-3e7oA:20.7 | 2itzA-3e7oA:25.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f1k | UNCHARACTERIZEDOXIDOREDUCTASE YCIK (Escherichiacoli) |
PF00106(adh_short) | 3 | LEU A 97LEU A 179MET A 176 | None | 0.81A | 2itzA-3f1kA:undetectable | 2itzA-3f1kA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f95 | BETA-GLUCOSIDASE (Pseudoalteromonassp. BB1) |
no annotation | 3 | LEU A 718LEU A 642MET A 646 | None | 0.83A | 2itzA-3f95A:undetectable | 2itzA-3f95A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3t | UBIQUITINCARBOXYL-TERMINALHYDROLASE 21 (Homo sapiens) |
PF00443(UCH) | 3 | LEU A 553LEU A 557MET A 558 | None | 0.80A | 2itzA-3i3tA:undetectable | 2itzA-3i3tA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5b | WSPR RESPONSEREGULATOR (Pseudomonasaeruginosa) |
PF00990(GGDEF) | 3 | LEU A 303LEU A 206MET A 207 | None | 0.84A | 2itzA-3i5bA:undetectable | 2itzA-3i5bA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iah | SHORT CHAINDEHYDROGENASE YCIK (Salmonellaenterica) |
PF00106(adh_short) | 3 | LEU A 97LEU A 179MET A 176 | None | 0.85A | 2itzA-3iahA:undetectable | 2itzA-3iahA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ixl | ARYLMALONATEDECARBOXYLASE (Bordetellabronchiseptica) |
no annotation | 3 | LEU A 99LEU A 72MET A 73 | None | 0.76A | 2itzA-3ixlA:undetectable | 2itzA-3ixlA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j4p | CAPSID PROTEIN VP1 (Adeno-associatedvirus) |
PF00740(Parvo_coat) | 3 | LEU A 649LEU A 405MET A 404 | None | 0.76A | 2itzA-3j4pA:undetectable | 2itzA-3j4pA:19.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | LEU A 764LEU A 768MET A 769 | ITI A 1 ( 4.2A)ITI A 1 (-4.8A)ITI A 1 (-4.8A) | 0.62A | 2itzA-3lzbA:34.3 | 2itzA-3lzbA:87.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4p | ASPARAGINYL-TRNASYNTHETASE, PUTATIVE (Entamoebahistolytica) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 3 | LEU A 237LEU A 223MET A 222 | 4AD A 500 (-4.4A)NoneNone | 0.87A | 2itzA-3m4pA:undetectable | 2itzA-3m4pA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3moi | PROBABLEDEHYDROGENASE (Bordetellabronchiseptica) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | LEU A 304LEU A 218MET A 217 | None | 0.74A | 2itzA-3moiA:undetectable | 2itzA-3moiA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ngw | MOLYBDOPTERIN-GUANINE DINUCLEOTIDEBIOSYNTHESIS PROTEINA (MOBA) (Archaeoglobusfulgidus) |
PF12804(NTP_transf_3) | 3 | LEU A 33LEU A 23MET A 22 | None | 0.86A | 2itzA-3ngwA:undetectable | 2itzA-3ngwA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyo | G PROTEIN-COUPLEDRECEPTOR KINASE 6 (Homo sapiens) |
PF00069(Pkinase)PF00615(RGS) | 3 | LEU A 261LEU A 265MET A 266 | NoneAMP A 577 ( 4.9A)None | 0.44A | 2itzA-3nyoA:19.9 | 2itzA-3nyoA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3of6 | PRE T-CELL ANTIGENRECEPTOR ALPHA (Homo sapiens) |
PF15028(PTCRA) | 3 | LEU D 76LEU D 19MET D 18 | None | 0.83A | 2itzA-3of6D:undetectable | 2itzA-3of6D:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oht | P38A (Salmo salar) |
PF00069(Pkinase) | 3 | LEU A 105LEU A 109MET A 110 | 1N1 A1000 (-4.2A)1N1 A1000 (-4.7A)None | 0.43A | 2itzA-3ohtA:16.6 | 2itzA-3ohtA:26.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oqb | OXIDOREDUCTASE (Bradyrhizobiumdiazoefficiens) |
PF01408(GFO_IDH_MocA) | 3 | LEU A 146LEU A 323MET A 294 | None | 0.60A | 2itzA-3oqbA:undetectable | 2itzA-3oqbA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oqb | OXIDOREDUCTASE (Bradyrhizobiumdiazoefficiens) |
PF01408(GFO_IDH_MocA) | 3 | LEU A 290LEU A 323MET A 294 | None | 0.83A | 2itzA-3oqbA:undetectable | 2itzA-3oqbA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pg1 | MITOGEN-ACTIVATEDPROTEIN KINASE,PUTATIVE (MAPKINASE-LIKE PROTEIN) (Leishmaniamajor) |
PF00069(Pkinase) | 3 | LEU A 110LEU A 114MET A 115 | None | 0.82A | 2itzA-3pg1A:20.4 | 2itzA-3pg1A:24.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pp0 | RECEPTORTYROSINE-PROTEINKINASE ERBB-2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | LEU A 796LEU A 800MET A 801 | 03Q A 1 (-4.3A)03Q A 1 (-4.6A)None | 0.41A | 2itzA-3pp0A:36.9 | 2itzA-3pp0A:78.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s29 | SUCROSE SYNTHASE 1 (Arabidopsisthaliana) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 3 | LEU A 581LEU A 296MET A 649 | NoneUDP A 901 (-3.7A)None | 0.77A | 2itzA-3s29A:undetectable | 2itzA-3s29A:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3syx | SPROUTY-RELATED,EVH1DOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00568(WH1) | 3 | LEU A 65LEU A 34MET A 22 | None | 0.77A | 2itzA-3syxA:undetectable | 2itzA-3syxA:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t3a | KILLER CELLLECTIN-LIKE RECEPTORSUBFAMILY B MEMBER1A (Mus musculus) |
PF00059(Lectin_C) | 3 | LEU A 214LEU A 131MET A 130 | None | 0.80A | 2itzA-3t3aA:undetectable | 2itzA-3t3aA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tlz | MCCF (Escherichiacoli) |
PF02016(Peptidase_S66) | 3 | LEU A 273LEU A 316MET A 315 | EDO A 347 ( 4.3A)NoneNone | 0.81A | 2itzA-3tlzA:undetectable | 2itzA-3tlzA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tuo | DNA-BINDING PROTEINSATB1 (Homo sapiens) |
PF16534(ULD) | 3 | LEU A 106LEU A 74MET A 73 | None | 0.81A | 2itzA-3tuoA:undetectable | 2itzA-3tuoA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u50 | TELOMERASE-ASSOCIATED PROTEIN 82 (Tetrahymenathermophila) |
PF08646(Rep_fac-A_C) | 3 | LEU C 673LEU C 587MET C 586 | None | 0.87A | 2itzA-3u50C:undetectable | 2itzA-3u50C:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ul3 | THIOREDOXIN (Plasmodiumfalciparum) |
no annotation | 3 | LEU B 106LEU B 137MET B 136 | None | 0.83A | 2itzA-3ul3B:undetectable | 2itzA-3ul3B:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w21 | PUTATIVEUNCHARACTERIZEDPROTEIN (Burkholderiaambifaria) |
no annotation | 3 | LEU A 245LEU A 230MET A 229 | None | 0.85A | 2itzA-3w21A:undetectable | 2itzA-3w21A:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bjj | TRANSCRIPTION FACTORTAU SUBUNIT SFC1TRANSCRIPTION FACTORTAU SUBUNIT SFC7 (Schizosaccharomycespombe) |
PF09734(Tau95)PF10419(TFIIIC_sub6) | 3 | LEU A 77LEU B 90MET B 89 | None | 0.85A | 2itzA-4bjjA:undetectable | 2itzA-4bjjA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7o | SIGNAL RECOGNITIONPARTICLE PROTEIN (Escherichiacoli) |
PF00448(SRP54)PF02881(SRP54_N) | 3 | LEU A 133LEU A 104MET A 105 | None | 0.83A | 2itzA-4c7oA:undetectable | 2itzA-4c7oA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e1l | ACETOACETYL-COATHIOLASE 2 (Clostridioidesdifficile) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 3 | LEU A 97LEU A 257MET A 256 | None | 0.75A | 2itzA-4e1lA:undetectable | 2itzA-4e1lA:24.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4feq | TYROSINE-PROTEINKINASE RECEPTORTYRO3 (Mus musculus) |
PF07714(Pkinase_Tyr) | 3 | LEU A 606LEU A 653MET A 652 | NoneNone0T8 A 901 (-3.9A) | 0.75A | 2itzA-4feqA:25.4 | 2itzA-4feqA:34.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gu7 | PUTATIVEUNCHARACTERIZEDPROTEIN SCO7193 (Streptomycescoelicolor) |
PF04261(Dyp_perox) | 3 | LEU A 239LEU A 228MET A 277 | NoneNoneHEM A 401 ( 3.8A) | 0.83A | 2itzA-4gu7A:undetectable | 2itzA-4gu7A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1t | RNA-DIRECTED RNAPOLYMERASE L (Calimammarenavirus) |
PF17296(ArenaCapSnatch) | 3 | LEU A 100LEU A 125MET A 123 | None | 0.75A | 2itzA-4i1tA:undetectable | 2itzA-4i1tA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4n | INTRACELLULARPROTEASE/AMIDASE (Vibrio cholerae) |
no annotation | 3 | LEU A 54LEU A 260MET A 259 | None | 0.47A | 2itzA-4i4nA:undetectable | 2itzA-4i4nA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igd | MANNAN-BINDINGLECTIN SERINEPROTEASE 1 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 3 | LEU A 524LEU A 601MET A 602 | None | 0.83A | 2itzA-4igdA:undetectable | 2itzA-4igdA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igl | YENC2 (Yersiniaentomophaga) |
no annotation | 3 | LEU B 371LEU B 421MET B 422 | None | 0.87A | 2itzA-4iglB:undetectable | 2itzA-4iglB:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ku4 | RAS-3 FROMCRYPHONECTRIAPARASITICA (Cryphonectriaparasitica) |
PF00071(Ras) | 3 | LEU A 136LEU A 17MET A 16 | None | 0.76A | 2itzA-4ku4A:undetectable | 2itzA-4ku4A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lob | POLYPRENYLSYNTHETASE (Acinetobacterbaumannii) |
PF00348(polyprenyl_synt) | 3 | LEU A 127LEU A 23MET A 20 | None | 0.73A | 2itzA-4lobA:undetectable | 2itzA-4lobA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mnd | CTPL-MYO-INOSITOL-1-PHOSPHATECYTIDYLYLTRANSFERASE/CDP-L-MYO-INOSITOLMYO-INOSITOLPHOSPHOTRANSFERASE (Archaeoglobusfulgidus) |
PF01066(CDP-OH_P_transf)PF12804(NTP_transf_3) | 3 | LEU A 108LEU A 72MET A 73 | None | 0.84A | 2itzA-4mndA:undetectable | 2itzA-4mndA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okq | HUT OPERON POSITIVEREGULATORY PROTEIN (Geobacillusthermodenitrificans) |
PF09021(HutP) | 3 | LEU A 137LEU A 94MET A 46 | None | 0.83A | 2itzA-4okqA:undetectable | 2itzA-4okqA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p22 | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME 1 (Homo sapiens) |
PF00899(ThiF)PF16190(E1_FCCH)PF16191(E1_4HB) | 3 | LEU A 70LEU A 62MET A 410 | None | 0.79A | 2itzA-4p22A:undetectable | 2itzA-4p22A:23.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4pwn | SERINE/THREONINE-PROTEIN KINASE WNK1 (Homo sapiens) |
PF00069(Pkinase) | 3 | LEU A 299LEU A 303MET A 304 | None | 0.41A | 2itzA-4pwnA:16.7 | 2itzA-4pwnA:30.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2j | DNA-BINDING PROTEINSATB1 (Mus musculus) |
PF16534(ULD)PF16557(CUTL) | 3 | LEU A 106LEU A 74MET A 73 | None | 0.76A | 2itzA-4q2jA:undetectable | 2itzA-4q2jA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s13 | FERULIC ACIDDECARBOXYLASE 1 (Saccharomycescerevisiae) |
PF01977(UbiD) | 3 | LEU A 341LEU A 333MET A 228 | NoneNone4VP A 601 ( 3.7A) | 0.62A | 2itzA-4s13A:undetectable | 2itzA-4s13A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tyh | MITOGEN-ACTIVATEDPROTEIN KINASE 14 (Mus musculus) |
PF00069(Pkinase) | 3 | LEU B 104LEU B 108MET B 109 | 39G B 401 ( 4.7A)39G B 401 ( 4.9A)39G B 401 (-4.8A) | 0.51A | 2itzA-4tyhB:21.7 | 2itzA-4tyhB:25.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ure | CYCLOHEXANOLDEHYDROGENASE (Aromatoleumaromaticum) |
PF13561(adh_short_C2) | 3 | LEU A 23LEU A 2MET A 1 | None | 0.70A | 2itzA-4ureA:undetectable | 2itzA-4ureA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhp | PARM HYBRID FUSIONPROTEIN (Bacillusthuringiensis) |
no annotation | 3 | LEU A 454LEU A 449MET A 448 | None | 0.87A | 2itzA-4xhpA:undetectable | 2itzA-4xhpA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0m | ENOYL-COA HYDRATASE (Mycobacteriumtuberculosis) |
PF00378(ECH_1) | 3 | LEU A 113LEU A 92MET A 91 | None | 0.77A | 2itzA-4z0mA:undetectable | 2itzA-4z0mA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0m | ENOYL-COA HYDRATASE (Mycobacteriumtuberculosis) |
PF00378(ECH_1) | 3 | LEU A 117LEU A 92MET A 91 | None | 0.84A | 2itzA-4z0mA:undetectable | 2itzA-4z0mA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a01 | O-GLYCOSYLTRANSFERASE (Drosophilamelanogaster) |
PF13374(TPR_10)PF13414(TPR_11)PF13844(Glyco_transf_41) | 3 | LEU A 971LEU A 946MET A 872 | None | 0.80A | 2itzA-5a01A:undetectable | 2itzA-5a01A:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a53 | RIBOSOME BIOGENESISPROTEIN RPF2 (Saccharomycescerevisiae) |
PF04427(Brix) | 3 | LEU C 86LEU C 89MET C 90 | None | 0.86A | 2itzA-5a53C:undetectable | 2itzA-5a53C:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awm | STRESS-ACTIVATEDPROTEIN KINASE JNK (Drosophilamelanogaster) |
PF00069(Pkinase) | 3 | LEU A 104LEU A 108MET A 109 | NoneANP A 401 ( 4.8A)None | 0.41A | 2itzA-5awmA:20.1 | 2itzA-5awmA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8l | HETERODIMERICGERANYLGERANYLPYROPHOSPHATESYNTHASE LARGESUBUNIT 1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00348(polyprenyl_synt) | 3 | LEU A 132LEU A 124MET A 86 | None | 0.54A | 2itzA-5e8lA:undetectable | 2itzA-5e8lA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5goo | ALKALINE INVERTASE (Nostoc sp. PCC7120) |
PF12899(Glyco_hydro_100) | 3 | LEU A 164LEU A 97MET A 98 | None | 0.75A | 2itzA-5gooA:undetectable | 2itzA-5gooA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hp5 | PROTEIN-ARGININEDEIMINASE TYPE-1 (Homo sapiens) |
PF03068(PAD)PF08526(PAD_N)PF08527(PAD_M) | 3 | LEU A 166LEU A 171MET A 172 | None | 0.83A | 2itzA-5hp5A:undetectable | 2itzA-5hp5A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikp | GLYCOGENPHOSPHORYLASE, BRAINFORM (Homo sapiens) |
PF00343(Phosphorylase) | 3 | LEU A 243LEU A 198MET A 197 | None | 0.86A | 2itzA-5ikpA:undetectable | 2itzA-5ikpA:16.96 |