SIMILAR PATTERNS OF AMINO ACIDS FOR 2ITY_A_IREA2020

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 GLY A 202
VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
ASP A 332
 None
 0.81A 2ityA-1k9aA:
32.4		 2ityA-1k9aA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.94A 2ityA-1opkA:
30.3		 2ityA-1opkA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 GLY A 212
VAL A 219
ALA A 230
LYS A 232
GLU A 245
LEU A 278
GLY A 286
LEU A 340
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.77A 2ityA-1py5A:
26.7		 2ityA-1py5A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 VAL A 219
ALA A 230
LYS A 232
GLU A 245
LEU A 278
GLY A 286
LEU A 340
ASP A 351
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.71A 2ityA-1py5A:
26.7		 2ityA-1py5A:
25.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LYS A 623
THR A 670
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.83A 2ityA-1t46A:
26.6		 2ityA-1t46A:
31.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  82
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
HYM  A 400 (-4.5A)
 0.81A 2ityA-1zltA:
22.2		 2ityA-1zltA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  82
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.78A 2ityA-1zltA:
22.2		 2ityA-1zltA:
25.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU X  17
GLY X  18
VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
THR X  82
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.84A 2ityA-2dq7X:
32.0		 2ityA-2dq7X:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
THR X  82
GLY X  88
LEU X 137
ASP X 148
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.81A 2ityA-2dq7X:
32.0		 2ityA-2dq7X:
33.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  59
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.82A 2ityA-2f9gA:
17.3		 2ityA-2f9gA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
THR A 338
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.79A 2ityA-2h8hA:
29.6		 2ityA-2h8hA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
GLY A 252
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
ASP A 382
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.72A 2ityA-2hk5A:
26.4		 2ityA-2hk5A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
GLY A 252
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.64A 2ityA-2hk5A:
26.4		 2ityA-2hk5A:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  55
GLY A  56
VAL A  63
ALA A  76
LYS A  78
LEU A 122
GLY A 130
LEU A 177
 None
 0.74A 2ityA-2hw6A:
20.8		 2ityA-2hw6A:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
GLY A 249
VAL A 256
ALA A 269
LYS A 271
GLU A 286
MET A 290
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 1.05A 2ityA-2hz0A:
30.7		 2ityA-2hz0A:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
GLY A 252
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
 None
None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
 0.69A 2ityA-2og8A:
29.9		 2ityA-2og8A:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		9 GLY B  48
VAL B  55
ALA B  67
LYS B  69
GLU B  85
LEU B 112
GLY B 120
LEU B 171
ASP B 182
 None
 1.12A 2ityA-2qkwB:
25.2		 2ityA-2qkwB:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 204
ALA A 215
LYS A 217
LEU A 263
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.67A 2ityA-2qluA:
25.9		 2ityA-2qluA:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 GLY A 682
VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
GLY A 759
LEU A 807
 None
 0.77A 2ityA-2r2pA:
34.2		 2ityA-2r2pA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 724
GLY A 725
VAL A 732
ALA A 749
LEU A 794
THR A 796
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.88A 2ityA-2r4bA:
35.8		 2ityA-2r4bA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 724
VAL A 732
ALA A 749
LYS A 751
LEU A 794
THR A 796
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.91A 2ityA-2r4bA:
35.8		 2ityA-2r4bA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 GLY A 628
VAL A 635
ALA A 651
LYS A 653
MET A 674
THR A 699
GLY A 705
LEU A 753
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.55A 2ityA-2xyuA:
28.9		 2ityA-2xyuA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1002
GLY A1003
VAL A1010
ALA A1028
GLU A1047
MET A1051
GLY A1082
ASP A1150
 S91  A   1 ( 4.1A)
S91  A   1 ( 3.9A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
None
S91  A   1 (-3.3A)
None
 0.76A 2ityA-2z8cA:
23.5		 2ityA-2z8cA:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 253
GLY A 254
VAL A 261
ALA A 273
LYS A 275
THR A 319
GLY A 325
LEU A 374
 None
 0.58A 2ityA-2zv7A:
32.9		 2ityA-2zv7A:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 253
VAL A 261
ALA A 273
LYS A 275
MET A 294
THR A 319
GLY A 325
LEU A 374
 None
 0.63A 2ityA-2zv7A:
32.9		 2ityA-2zv7A:
33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  91
ASP A 161
 4RB  A 401 ( 3.9A)
4RB  A 401 (-3.6A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
GOL  A 503 (-2.8A)
None
GOL  A 503 ( 3.1A)
 0.75A 2ityA-3bqrA:
22.4		 2ityA-3bqrA:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 GLY A 202
VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
ASP A 332
 None
 0.80A 2ityA-3d7uA:
27.1		 2ityA-3d7uA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 GLY A 640
VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
GLY A 717
LEU A 765
 None
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.80A 2ityA-3dkoA:
31.7		 2ityA-3dkoA:
31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 217
ALA A 228
LYS A 230
GLU A 243
LEU A 277
GLY A 285
LEU A 340
ASP A 351
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.79A 2ityA-3g2fA:
26.1		 2ityA-3g2fA:
25.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 696
GLY A 697
VAL A 704
LYS A 723
LEU A 766
THR A 768
GLY A 774
LEU A 822
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.7A)
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.8A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
 0.71A 2ityA-3kexA:
31.8		 2ityA-3kexA:
55.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.87A 2ityA-3kulA:
34.1		 2ityA-3kulA:
32.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.73A 2ityA-3nyoA:
19.9		 2ityA-3nyoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.80A 2ityA-3nyoA:
19.9		 2ityA-3nyoA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
LEU A 796
THR A 798
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.75A 2ityA-3pp0A:
37.0		 2ityA-3pp0A:
78.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 GLY A 558
VAL A 565
ALA A 576
LYS A 578
MET A 600
THR A 625
GLY A 631
ASP A 694
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-3.5A)
 0.83A 2ityA-3ppzA:
29.7		 2ityA-3ppzA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
GLY A  64
VAL A  71
ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
 0.71A 2ityA-3q5iA:
23.0		 2ityA-3q5iA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 423
GLY A 424
VAL A 431
ALA A 443
MET A 464
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.73A 2ityA-3sxsA:
30.7		 2ityA-3sxsA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1951
GLY A1952
VAL A1959
ALA A1978
LYS A1980
GLU A1997
MET A2001
GLY A2032
ASP A2102
 VGH  A3000 ( 4.4A)
None
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-3.5A)
None
 0.81A 2ityA-3zbfA:
28.6		 2ityA-3zbfA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1951
GLY A1952
VAL A1959
ALA A1978
LYS A1980
MET A2001
GLY A2032
LEU A2086
ASP A2102
 VGH  A3000 ( 4.4A)
None
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
 0.69A 2ityA-3zbfA:
28.6		 2ityA-3zbfA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 GLY A 626
VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
GLY A 703
LEU A 751
ASP A 762
 None
 0.74A 2ityA-3zfxA:
34.5		 2ityA-3zfxA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A 626
VAL A 633
ALA A 649
MET A 672
THR A 697
GLY A 703
LEU A 751
ASP A 762
 None
 0.58A 2ityA-3zfxA:
34.5		 2ityA-3zfxA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 GLY A  98
VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.82A 2ityA-4aw5A:
29.2		 2ityA-4aw5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 GLY A  98
VAL A 105
ALA A 121
LYS A 123
MET A 144
THR A 169
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.67A 2ityA-4aw5A:
29.2		 2ityA-4aw5A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		9 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
THR A 283
GLY A 289
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.79A 2ityA-4c02A:
20.8		 2ityA-4c02A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		9 LEU A 246
GLY A 247
VAL A 254
ALA A 267
LYS A 269
GLU A 288
GLY A 324
LEU A 371
ASP A 382
 None
 0.95A 2ityA-4c0tA:
23.1		 2ityA-4c0tA:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
GLY A 617
VAL A 624
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
 None
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
 0.66A 2ityA-4ckrA:
29.3		 2ityA-4ckrA:
33.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
LEU A 446
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.72A 2ityA-4f4pA:
32.9		 2ityA-4f4pA:
39.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		8 GLY A 328
VAL A 335
ALA A 348
LYS A 350
GLU A 366
MET A 370
GLY A 401
LEU A 447
 ANP  A1001 (-4.4A)
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 (-3.6A)
None
None
ANP  A1001 (-4.7A)
 0.82A 2ityA-4fieA:
23.6		 2ityA-4fieA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
LEU A 446
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.69A 2ityA-4fl3A:
30.0		 2ityA-4fl3A:
25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1122
GLY A1123
VAL A1130
ALA A1148
LYS A1150
GLU A1167
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 ( 4.3A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.97A 2ityA-4fodA:
31.2		 2ityA-4fodA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 855
GLY A 856
VAL A 863
ALA A 880
LYS A 882
GLU A 898
LEU A 927
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.89A 2ityA-4gl9A:
31.0		 2ityA-4gl9A:
34.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 828
GLY A 829
VAL A 836
ALA A 853
LYS A 855
GLU A 871
LEU A 900
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 1.01A 2ityA-4hviA:
31.8		 2ityA-4hviA:
34.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
GLY A 211
LEU A 259
ASP A 270
 None
 0.71A 2ityA-4hzsA:
29.4		 2ityA-4hzsA:
36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
 None
 0.73A 2ityA-4hzsA:
29.4		 2ityA-4hzsA:
36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.76A 2ityA-4id7A:
32.6		 2ityA-4id7A:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		9 LEU A 258
GLY A 259
VAL A 266
ALA A 279
LYS A 281
GLU A 300
LEU A 354
LEU A 416
ASP A 427
 ANP  A 601 ( 4.6A)
ANP  A 601 (-3.4A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
None
None
ANP  A 601 ( 4.9A)
MG  A 603 ( 2.0A)
 1.02A 2ityA-4jrnA:
21.0		 2ityA-4jrnA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
GLY A 344
LEU A 393
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.78A 2ityA-4k11A:
29.3		 2ityA-4k11A:
26.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
GLY A 479
VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
ASP A 635
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
MG  A 802 ( 3.0A)
 0.80A 2ityA-4k33A:
28.6		 2ityA-4k33A:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 478
VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
GLY A 561
LEU A 624
ASP A 635
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
MG  A 802 ( 3.0A)
 0.78A 2ityA-4k33A:
28.6		 2ityA-4k33A:
32.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A 414
VAL A 421
ALA A 434
LYS A 436
MET A 456
GLY A 487
LEU A 533
ASP A 544
 B49  A 701 ( 4.3A)
None
B49  A 701 (-3.2A)
None
None
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.74A 2ityA-4ks8A:
25.1		 2ityA-4ks8A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  33
GLY A  34
VAL A  41
ALA A  54
LYS A  56
GLU A  70
MET A  74
GLY A 105
LEU A 153
ASP A 164
 GOL  A 404 ( 3.6A)
None
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 (-2.4A)
 0.84A 2ityA-4lg4A:
19.9		 2ityA-4lg4A:
29.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
GLY A 344
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.7A)
 0.92A 2ityA-4lggA:
29.7		 2ityA-4lggA:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.65A 2ityA-4lggA:
29.7		 2ityA-4lggA:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		8 GLY A  29
VAL A  36
ALA A  49
LYS A  51
LEU A  93
THR A  95
GLY A 101
LEU A 150
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
 0.68A 2ityA-4m69A:
24.2		 2ityA-4m69A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 LEU A  78
GLY A  79
VAL A  86
ALA A  99
LYS A 101
GLU A 117
MET A 121
LEU A 144
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
None
STU  A 601 (-4.3A)
 0.85A 2ityA-4mvfA:
20.8		 2ityA-4mvfA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
LEU A 121
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.87A 2ityA-4o38A:
20.7		 2ityA-4o38A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
LEU A 121
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.5A)
None
 0.85A 2ityA-4o38A:
20.7		 2ityA-4o38A:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 GLY A 620
VAL A 627
ALA A 644
GLU A 663
MET A 667
THR A 692
GLY A 698
LEU A 746
ASP A 757
 None
 0.97A 2ityA-4p2kA:
34.4		 2ityA-4p2kA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 386
GLY A 387
VAL A 394
ALA A 407
LYS A 409
GLU A 428
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.67A 2ityA-4q9zA:
22.2		 2ityA-4q9zA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.83A 2ityA-4rt7A:
26.2		 2ityA-4rt7A:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
SGV  A 601 (-3.0A)
 0.83A 2ityA-4tnbA:
17.9		 2ityA-4tnbA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
GLY A  15
ALA A  35
LYS A  37
MET A  56
THR A  81
GLY A  87
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
 0.69A 2ityA-4ueuA:
32.4		 2ityA-4ueuA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 LEU A  14
GLY A  15
VAL A  22
ALA A  35
LYS A  37
MET A  56
THR A  81
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.59A 2ityA-4ueuA:
32.4		 2ityA-4ueuA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
GLY A  15
VAL A  22
LYS A  37
GLU A  52
MET A  56
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
None
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.71A 2ityA-4ueuA:
32.4		 2ityA-4ueuA:
35.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
GLU A 235
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.76A 2ityA-4wboA:
23.6		 2ityA-4wboA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 262
ASP A 332
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
None
None
 0.76A 2ityA-4wboA:
23.6		 2ityA-4wboA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		8 GLY A 328
VAL A 335
ALA A 348
LYS A 350
MET A 370
GLY A 401
LEU A 447
ASP A 458
 ATP  A 601 ( 4.1A)
ATP  A 601 (-4.4A)
ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
None
None
None
ATP  A 601 ( 2.5A)
 0.56A 2ityA-4xbrA:
19.9		 2ityA-4xbrA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
VAL B 275
ALA B 288
LYS B 290
MET B 309
THR B 334
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.69A 2ityA-4xeyB:
26.7		 2ityA-4xeyB:
28.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.87A 2ityA-4xufA:
23.6		 2ityA-4xufA:
33.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 262
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
 0.80A 2ityA-4yhjA:
22.4		 2ityA-4yhjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.81A 2ityA-4ysjA:
24.4		 2ityA-4ysjA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
GLY A 485
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.83A 2ityA-5a46A:
30.8		 2ityA-5a46A:
31.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 GLY A 251
VAL A 258
ALA A 275
LYS A 277
GLU A 290
LEU A 323
THR A 325
GLY A 331
LEU A 386
 STU  A 601 (-2.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
None
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.70A 2ityA-5e8yA:
25.7		 2ityA-5e8yA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 258
ALA A 275
LYS A 277
GLU A 290
LEU A 323
THR A 325
GLY A 331
ASP A 397
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
None
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.0A)
 0.71A 2ityA-5e8yA:
25.7		 2ityA-5e8yA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		8 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 168
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.76A 2ityA-5eykA:
19.3		 2ityA-5eykA:
24.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
 0.77A 2ityA-5grnA:
24.6		 2ityA-5grnA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.85A 2ityA-5grnA:
24.6		 2ityA-5grnA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 718
GLY A 719
VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
LEU A 788
GLY A 796
LEU A 844
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.62A 2ityA-5j9zA:
44.4		 2ityA-5j9zA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A 397
VAL A 404
ALA A 417
LYS A 419
GLU A 436
LEU A 463
GLY A 471
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.71A 2ityA-5jznA:
24.1		 2ityA-5jznA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		9 GLY A 890
VAL A 897
ALA A 909
LYS A 911
GLU A 927
LEU A 954
GLY A 962
LEU A1016
ASP A1027
 ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
 0.73A 2ityA-5lpyA:
24.6		 2ityA-5lpyA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		9 GLY A 890
VAL A 897
ALA A 909
LYS A 911
GLU A 927
LEU A 954
GLY A 962
LEU A1016
ASP A1027
 ADP  A1200 ( 4.0A)
ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 (-3.4A)
 0.73A 2ityA-5lpzA:
24.7		 2ityA-5lpzA:
26.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 593
GLY A 594
VAL A 601
ALA A 617
LYS A 619
MET A 641
GLY A 677
ASP A 741
 7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.2A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.1A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
 0.83A 2ityA-5td2A:
24.2		 2ityA-5td2A:
34.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 8 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A 118
ASP A 186
 None
None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
None
 0.74A 2ityA-5turA:
23.1		 2ityA-5turA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY A  99
VAL A 106
ALA A 119
LYS A 121
GLU A 140
MET A 144
GLY A 175
LEU A 221
ASP A 232
 None
 0.84A 2ityA-5u7qA:
21.1		 2ityA-5u7qA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.81A 2ityA-5wnoA:
31.4		 2ityA-5wnoA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 9 GLY A 219
VAL A 226
ALA A 237
LYS A 239
GLU A 259
LEU A 286
GLY A 294
LEU A 347
ASP A 358
 DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
None
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 1.00A 2ityA-6bfnA:
25.0		 2ityA-6bfnA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 9 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A 954
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.84A 2ityA-6c7yA:
30.9		 2ityA-6c7yA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 8 GLY A 135
VAL A 142
ALA A 155
LYS A 157
LEU A 228
GLY A 236
LEU A 282
ASP A 293
 H1N  A 501 ( 3.8A)
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-2.8A)
None
H1N  A 501 (-3.6A)
H1N  A 501 (-4.8A)
H1N  A 501 (-3.5A)
 0.72A 2ityA-6ccfA:
23.2		 2ityA-6ccfA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 8 LEU U  20
GLY U  21
VAL U  28
ALA U  42
LYS U  44
LEU U  89
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.68A 2ityA-6fdyU:
22.6		 2ityA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 8 LEU U  20
GLY U  21
VAL U  28
ALA U  42
LYS U  44
LEU U  89
LEU U 144
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.83A 2ityA-6fdyU:
22.6		 2ityA-6fdyU:
undetectable