SIMILAR PATTERNS OF AMINO ACIDS FOR 2IT4_A_PPFA500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 HIS A  88
HIS A 274
HIS A 118
VAL A 108
HIS A 244
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
C2O  A 500 ( 3.2A)
 1.45A 2it4A-1bt2A:
undetectable		 2it4A-1bt2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR RECEPTOR 1

(Homo sapiens) 		PF07679
(I-set) 		5 HIS C 292
VAL C 308
LEU C 342
THR C 340
HIS C 351
 None
 1.28A 2it4A-1fq9C:
undetectable		 2it4A-1fq9C:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibx CHIMERA OF IGG
BINDING PROTEIN G
AND DNA
FRAGMENTATION FACTOR
45

(Homo sapiens;
Streptococcus
sp.) 		PF02017
(CIDE-N) 		4 ALA B  89
VAL B  59
LEU B  50
HIS B  32
 None
 0.79A 2it4A-1ibxB:
undetectable		 2it4A-1ibxB:
24.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
 0.26A 2it4A-1jd0A:
35.6		 2it4A-1jd0A:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
VAL A 121
LEU A 198
THR A 199
 ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
 0.82A 2it4A-1jd0A:
35.6		 2it4A-1jd0A:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 HIS A  92
HIS A  94
HIS A 111
VAL A 123
LEU A 176
THR A 177
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
 0.31A 2it4A-1kopA:
29.5		 2it4A-1kopA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
VAL A 113
LEU A 176
THR A 177
 ZN  A 301 ( 3.3A)
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
 0.89A 2it4A-1kopA:
29.5		 2it4A-1kopA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk3 APOPTOSIS REGULATOR
BCL-W

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 ALA A  97
VAL A 100
LEU A  63
THR A  59
 None
 0.87A 2it4A-1mk3A:
undetectable		 2it4A-1mk3A:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 3.2A)
None
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
 0.34A 2it4A-1rj6A:
36.1		 2it4A-1rj6A:
35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
VAL A 121
LEU A 198
THR A 199
 ZN  A 601 (-3.3A)
AZM  A 400 (-4.8A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
 0.84A 2it4A-1rj6A:
36.1		 2it4A-1rj6A:
35.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		4 ALA A  91
VAL A 113
LEU A 234
HIS A 235
 None
 0.84A 2it4A-1tqhA:
undetectable		 2it4A-1tqhA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 HIS A 146
HIS A   9
ALA A 354
LEU A  63
THR A  60
 None
 1.49A 2it4A-1ufaA:
undetectable		 2it4A-1ufaA:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
 0.37A 2it4A-1urtA:
36.6		 2it4A-1urtA:
47.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965

(Mycobacterium
tuberculosis) 		PF01068
(DNA_ligase_A_M)
PF04679
(DNA_ligase_A_C) 		5 HIS A 523
ALA A 491
VAL A 525
LEU A 590
THR A 588
 None
 1.39A 2it4A-1vs0A:
undetectable		 2it4A-1vs0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkc HB8 TT1367 PROTEIN

(Thermus
thermophilus) 		PF01812
(5-FTHF_cyc-lig) 		4 HIS A 162
ALA A 164
VAL A 169
LEU A  34
 None
 0.83A 2it4A-1wkcA:
undetectable		 2it4A-1wkcA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		6 HIS A 115
HIS A 117
HIS A 135
VAL A 153
LEU A 216
THR A 217
 ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ZN  A 283 ( 3.1A)
None
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
 0.27A 2it4A-1y7wA:
25.0		 2it4A-1y7wA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		4 HIS A 117
VAL A 137
LEU A 216
THR A 217
 ZN  A 283 (-3.2A)
ACY  A 279 ( 4.7A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
 0.81A 2it4A-1y7wA:
25.0		 2it4A-1y7wA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 HIS A 394
ALA A 510
VAL A 541
THR A 495
 None
 0.80A 2it4A-2a3lA:
undetectable		 2it4A-2a3lA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 HIS X 146
HIS X  10
ALA X 350
LEU X  61
THR X  58
 None
 1.28A 2it4A-2b5dX:
undetectable		 2it4A-2b5dX:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		4 ALA C 661
VAL A  72
LEU A 131
THR A 132
 None
 0.90A 2it4A-2e1mC:
undetectable		 2it4A-2e1mC:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gex SNOL

(Streptomyces
nogalater) 		PF07366
(SnoaL) 		4 HIS A  86
ALA A  84
VAL A 100
LEU A 145
 None
 0.88A 2it4A-2gexA:
undetectable		 2it4A-2gexA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		4 HIS A 346
ALA A 344
LEU A  62
THR A  63
 None
 0.83A 2it4A-2o78A:
undetectable		 2it4A-2o78A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		4 HIS A  73
HIS A  99
VAL A  97
THR A  62
 None
FE  A 278 (-3.1A)
None
None
 0.80A 2it4A-2p17A:
undetectable		 2it4A-2p17A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		4 HIS A 237
HIS A 235
HIS A 255
LEU A 202
 MET  A 600 (-3.9A)
MET  A 600 (-4.4A)
MET  A 600 ( 4.3A)
MET  A 600 (-3.7A)
 0.85A 2it4A-2qs8A:
undetectable		 2it4A-2qs8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsf DNA REPAIR PROTEIN
RAD4

(Saccharomyces
cerevisiae) 		PF03835
(Rad4)
PF10403
(BHD_1)
PF10405
(BHD_3) 		4 ALA A 280
VAL A 319
LEU A 183
HIS A 184
 None
 0.91A 2it4A-2qsfA:
undetectable		 2it4A-2qsfA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 118
HIS A 141
LEU A 222
THR A 223
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
 0.29A 2it4A-2w2jA:
35.1		 2it4A-2w2jA:
39.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 HIS A 108
HIS A 154
ALA A 193
HIS A  38
 FE  A 502 (-3.5A)
FE  A 502 (-3.4A)
None
ZN  A 501 (-3.2A)
 0.90A 2it4A-2z4gA:
undetectable		 2it4A-2z4gA:
23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
None
ZN  A   1 ( 4.7A)
 0.30A 2it4A-2zncA:
30.1		 2it4A-2zncA:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 163
HIS A 165
HIS A 182
VAL A 201
LEU A 259
THR A 260
 ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 (-3.1A)
None
None
ZN  A 378 ( 4.5A)
 0.29A 2it4A-3b1bA:
24.7		 2it4A-3b1bA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 HIS A 165
VAL A 184
LEU A 259
THR A 260
 ZN  A 378 (-3.3A)
None
None
ZN  A 378 ( 4.5A)
 0.79A 2it4A-3b1bA:
24.7		 2it4A-3b1bA:
24.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  95
HIS A  97
HIS A 120
VAL A 144
LEU A 199
THR A 200
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
 0.47A 2it4A-3da2A:
42.5		 2it4A-3da2A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  97
VAL A 122
LEU A 199
THR A 200
 ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
 0.74A 2it4A-3da2A:
42.5		 2it4A-3da2A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 111
HIS A 113
HIS A 138
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
 0.85A 2it4A-3fe4A:
30.3		 2it4A-3fe4A:
34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		4 HIS A 141
VAL A  40
LEU A 227
THR A 288
 None
 0.86A 2it4A-3k25A:
undetectable		 2it4A-3k25A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		5 HIS A4260
ALA A4255
VAL A4262
LEU A4314
HIS A4312
 None
 1.44A 2it4A-3kciA:
undetectable		 2it4A-3kciA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
 0.28A 2it4A-3ml5A:
40.5		 2it4A-3ml5A:
51.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
VAL A 121
LEU A 198
THR A 199
 ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
 0.86A 2it4A-3ml5A:
40.5		 2it4A-3ml5A:
51.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv) 		4 HIS B 219
ALA B 215
VAL B 154
LEU B 165
 None
 0.83A 2it4A-3napB:
undetectable		 2it4A-3napB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 HIS A 285
ALA A 334
LEU A 296
HIS A 257
 None
 0.92A 2it4A-3ogrA:
undetectable		 2it4A-3ogrA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 HIS A 117
HIS A  93
ALA A  95
LEU A 211
 None
 0.91A 2it4A-3pkjA:
undetectable		 2it4A-3pkjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		6 HIS A 123
HIS A 125
HIS A 142
VAL A 154
LEU A 214
THR A 215
 ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 3.2A)
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
 0.36A 2it4A-3q31A:
23.5		 2it4A-3q31A:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		5 HIS A 125
HIS A 142
VAL A 144
LEU A 214
THR A 215
 ZN  A   1 (-3.3A)
ZN  A   1 ( 3.2A)
None
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
 1.11A 2it4A-3q31A:
23.5		 2it4A-3q31A:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE

(Alteromonas
macleodii) 		PF00557
(Peptidase_M24) 		4 HIS A 299
HIS A 303
HIS A 366
ALA A 362
 None
 0.82A 2it4A-3rvaA:
undetectable		 2it4A-3rvaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un1 PROBABLE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 HIS A 125
VAL A  77
LEU A 212
HIS A 216
 None
 0.91A 2it4A-3un1A:
undetectable		 2it4A-3un1A:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A  96
HIS A 119
VAL A 142
THR A 198
 ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
ZN  A 261 ( 4.4A)
 0.28A 2it4A-3uyqA:
41.0		 2it4A-3uyqA:
55.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx EXOU

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		4 HIS B 242
ALA B 246
VAL B 245
LEU B 272
 None
 0.86A 2it4A-4akxB:
undetectable		 2it4A-4akxB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amg SNOGD

(Streptomyces
nogalater) 		PF06722
(DUF1205) 		4 ALA A  15
VAL A  43
LEU A  32
THR A  29
 None
 0.82A 2it4A-4amgA:
undetectable		 2it4A-4amgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A  42
HIS A  69
ALA A  56
LEU A 344
HIS A 183
 CUO  A9001 (-3.4A)
CUO  A9001 (-3.1A)
None
None
CUO  A9001 (-3.4A)
 1.23A 2it4A-4bedA:
undetectable		 2it4A-4bedA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		4 ALA A  99
VAL A 100
THR A 238
HIS A  85
 None
 0.91A 2it4A-4bhdA:
undetectable		 2it4A-4bhdA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE

(Pantoea
ananatis) 		PF01593
(Amino_oxidase) 		5 HIS A 322
HIS A 353
HIS A 323
VAL A 213
THR A  55
 None
EDO  A 602 (-3.8A)
None
None
None
 1.27A 2it4A-4dgkA:
undetectable		 2it4A-4dgkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Yersinia pestis) 		PF00005
(ABC_tran) 		4 ALA C 153
LEU C 189
THR C 186
HIS C 185
 None
 0.81A 2it4A-4g1uC:
undetectable		 2it4A-4g1uC:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
HIS A  91
HIS A 108
VAL A 120
LEU A 173
THR A 174
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
 0.35A 2it4A-4g7aA:
28.6		 2it4A-4g7aA:
31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Escherichia
coli) 		PF02401
(LYTB) 		4 HIS A 124
VAL A 127
LEU A 169
THR A 168
 10D  A 402 (-4.0A)
None
None
10D  A 402 (-3.5A)
 0.89A 2it4A-4h4cA:
undetectable		 2it4A-4h4cA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Anaerococcus
prevotii) 		PF01128
(IspD) 		4 HIS A 106
ALA A   9
LEU A  41
THR A  40
 None
 0.85A 2it4A-4kt7A:
undetectable		 2it4A-4kt7A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3w LIPASE

(Rhizopus
microsporus) 		PF01764
(Lipase_3) 		4 ALA A  36
VAL A 259
LEU A  44
THR A  45
 None
 0.89A 2it4A-4l3wA:
undetectable		 2it4A-4l3wA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		4 HIS A 217
ALA A 258
LEU A 238
THR A 239
 None
 0.80A 2it4A-4lg8A:
undetectable		 2it4A-4lg8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7b LYTB

(Plasmodium
falciparum) 		PF02401
(LYTB) 		4 HIS A 126
VAL A 129
LEU A 168
THR A 167
 SO4  A 402 (-4.1A)
None
None
SO4  A 402 (-3.4A)
 0.84A 2it4A-4n7bA:
undetectable		 2it4A-4n7bA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE

(Mesorhizobium
japonicum) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		4 HIS A 234
VAL A 236
LEU A 205
THR A 204
 None
 0.89A 2it4A-4p7wA:
undetectable		 2it4A-4p7wA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG

(Homo sapiens) 		PF08514
(STAG)
no annotation 		4 HIS A 421
ALA A 425
VAL A 424
LEU B 351
 None
 0.73A 2it4A-4pjuA:
undetectable		 2it4A-4pjuA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		4 HIS A 247
ALA A 218
LEU A 191
THR A 192
 None
 0.90A 2it4A-4pucA:
undetectable		 2it4A-4pucA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
 0.21A 2it4A-4qk3A:
39.5		 2it4A-4qk3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
 1.02A 2it4A-4qk3A:
39.5		 2it4A-4qk3A:
59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvg SIBL

(Streptosporangium
sibiricum) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 HIS A 238
ALA A 265
LEU A 200
HIS A 225
 None
 0.87A 2it4A-4qvgA:
undetectable		 2it4A-4qvgA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 HIS A 112
HIS A 114
HIS A 131
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.42A 2it4A-4uovA:
30.2		 2it4A-4uovA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		4 HIS B 942
HIS B 937
HIS B 744
THR B 732
 ZN  B1101 (-3.2A)
ZN  B1101 (-3.2A)
None
None
 0.76A 2it4A-4wwxB:
undetectable		 2it4A-4wwxB:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
HIS A  91
HIS A 108
VAL A 120
LEU A 173
THR A 174
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 0.37A 2it4A-4x5sA:
28.8		 2it4A-4x5sA:
39.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xea PEPTIDASE M16 DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 HIS A 341
ALA A 311
VAL A 324
LEU A 416
 ACT  A 504 (-4.7A)
None
None
None
 0.89A 2it4A-4xeaA:
undetectable		 2it4A-4xeaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		4 HIS A 245
HIS A 148
VAL A 107
LEU A 133
 None
 0.87A 2it4A-4xf5A:
undetectable		 2it4A-4xf5A:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		6 HIS A 110
HIS A 112
HIS A 129
VAL A 141
LEU A 190
THR A 191
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 ( 3.1A)
None
None
ZN  A 301 (-4.3A)
 0.40A 2it4A-4xfwA:
25.7		 2it4A-4xfwA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		5 HIS A 112
HIS A 129
VAL A 131
LEU A 190
THR A 191
 ZN  A 301 (-3.4A)
ZN  A 301 ( 3.1A)
None
None
ZN  A 301 (-4.3A)
 1.15A 2it4A-4xfwA:
25.7		 2it4A-4xfwA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 160
HIS A 162
HIS A 179
VAL A 192
LEU A 253
THR A 254
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
 0.23A 2it4A-4xixA:
26.2		 2it4A-4xixA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 HIS A 162
HIS A 179
VAL A 181
LEU A 253
THR A 254
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
 0.99A 2it4A-4xixA:
26.2		 2it4A-4xixA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 HIS A 165
HIS A 167
HIS A 184
VAL A 196
LEU A 251
THR A 252
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.1A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
 0.26A 2it4A-4xz5A:
28.9		 2it4A-4xz5A:
34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		4 HIS A 167
VAL A 186
LEU A 251
THR A 252
 ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
 0.89A 2it4A-4xz5A:
28.9		 2it4A-4xz5A:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 116
HIS A 153
HIS A 121
ALA A 306
 ZN  A 401 ( 3.5A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.4A)
None
 0.90A 2it4A-4ymkA:
undetectable		 2it4A-4ymkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Sphaerobacter
thermophilus) 		PF13458
(Peripla_BP_6) 		4 ALA A 151
VAL A  85
LEU A 108
THR A 105
 None
 0.77A 2it4A-4zpjA:
undetectable		 2it4A-4zpjA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		4 HIS A 188
HIS A 260
ALA A 264
VAL A 349
 LLP  A 187 ( 4.8A)
None
None
None
 0.84A 2it4A-4zwvA:
undetectable		 2it4A-4zwvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a) 		4 ALA C 431
VAL C 353
LEU C 378
HIS C 375
 None
 0.91A 2it4A-5a6fC:
undetectable		 2it4A-5a6fC:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE

(Serratia
marcescens) 		PF00753
(Lactamase_B) 		4 ALA A 213
VAL A 218
LEU A 176
THR A 177
 None
HIW  A 321 (-4.6A)
None
HIW  A 321 ( 2.8A)
 0.80A 2it4A-5b1uA:
undetectable		 2it4A-5b1uA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE

(Serratia
marcescens) 		PF00753
(Lactamase_B) 		5 HIS A  72
HIS A 150
HIS A  74
ALA A  78
HIS A 215
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 302 ( 3.3A)
 1.37A 2it4A-5b1uA:
undetectable		 2it4A-5b1uA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
 0.27A 2it4A-5cjfA:
35.7		 2it4A-5cjfA:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
VAL A 121
LEU A 198
THR A 199
 ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
 0.81A 2it4A-5cjfA:
35.7		 2it4A-5cjfA:
35.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuo PHOSPHATE
PROPANOYLTRANSFERASE

(Rhodopseudomonas
palustris) 		PF06130
(PTAC) 		4 HIS A 157
HIS A 159
HIS A 204
ALA A 154
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.4A)
ZN  A 502 ( 3.1A)
None
 0.91A 2it4A-5cuoA:
undetectable		 2it4A-5cuoA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 HIS X  93
HIS X  95
HIS X 118
VAL X 141
LEU X 196
THR X 197
 ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
ZN  X 301 (-3.1A)
None
None
ZN  X 301 ( 4.4A)
 0.22A 2it4A-5eztX:
41.6		 2it4A-5eztX:
58.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		4 HIS X  95
VAL X 120
LEU X 196
THR X 197
 ZN  X 301 (-3.2A)
None
None
ZN  X 301 ( 4.4A)
 0.79A 2it4A-5eztX:
41.6		 2it4A-5eztX:
58.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffo INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta) 		4 ALA B 312
VAL B 252
LEU B 138
THR B 134
 None
 0.91A 2it4A-5ffoB:
undetectable		 2it4A-5ffoB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 444
HIS A 398
HIS A 137
VAL A 142
HIS A  97
 CU  A1463 (-3.0A)
CU  A1463 (-2.9A)
CU  A1463 (-3.3A)
None
CU  A1465 (-3.1A)
 1.12A 2it4A-5g3fA:
undetectable		 2it4A-5g3fA:
20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		6 HIS A  96
HIS A  98
HIS A 115
VAL A 127
LEU A 181
THR A 182
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
 0.33A 2it4A-5hpjA:
28.3		 2it4A-5hpjA:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		5 HIS A  98
HIS A 115
VAL A 117
LEU A 181
THR A 182
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
 1.12A 2it4A-5hpjA:
28.3		 2it4A-5hpjA:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
 0.39A 2it4A-5jn9A:
30.9		 2it4A-5jn9A:
31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Homo sapiens) 		no annotation 4 HIS B 260
ALA B 297
LEU B 277
THR B 278
 None
 0.84A 2it4A-5nnzB:
undetectable		 2it4A-5nnzB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		4 HIS A  44
ALA A  49
LEU A  87
THR A  86
 None
 0.77A 2it4A-5v1sA:
undetectable		 2it4A-5v1sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		4 ALA A 423
VAL A 422
LEU A 504
THR A 500
 None
 0.85A 2it4A-5w0sA:
undetectable		 2it4A-5w0sA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3s -

(-) 		no annotation 4 HIS A 822
ALA A 824
LEU A 849
THR A 850
 None
 0.88A 2it4A-5y3sA:
undetectable		 2it4A-5y3sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 4 HIS A 942
HIS A 937
HIS A 744
THR A 732
 ZN  A1101 (-3.3A)
ZN  A1101 (-3.4A)
None
None
 0.75A 2it4A-6cg0A:
undetectable		 2it4A-6cg0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 6 HIS A 117
HIS A 119
HIS A 136
VAL A 148
LEU A 201
THR A 202
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 (-4.4A)
 0.30A 2it4A-6ekiA:
29.8		 2it4A-6ekiA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 4 HIS A 119
VAL A 138
LEU A 201
THR A 202
 ZN  A 301 (-3.3A)
None
None
ZN  A 301 (-4.4A)
 0.82A 2it4A-6ekiA:
29.8		 2it4A-6ekiA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 4 HIS F 355
ALA F 352
LEU F  76
THR F  75
 None
 0.75A 2it4A-6f0kF:
undetectable		 2it4A-6f0kF:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
 0.42A 2it4A-6fe1A:
32.5		 2it4A-6fe1A:
15.89