SIMILAR PATTERNS OF AMINO ACIDS FOR 2IJ7_C_TPFC2471

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 VAL B 375
ASN B 381
PHE A  52
ALA A  34
 None
 1.10A 2ij7C-1as4B:
undetectable		 2ij7C-1as4B:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		4 THR A  24
ASN A  68
PHE A  21
ALA A 157
 None
 1.03A 2ij7C-1cf5A:
0.0		 2ij7C-1cf5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Bacillus
subtilis) 		PF00215
(OMPdecase) 		4 THR A 179
VAL A 159
VAL A 144
ALA A 172
 None
 0.89A 2ij7C-1dbtA:
undetectable		 2ij7C-1dbtA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		4 THR B 414
ASN B 284
PHE B 533
ALA B 507
 None
 1.08A 2ij7C-1e3dB:
0.0		 2ij7C-1e3dB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL A 316
ASN A 314
ALA A 283
GLN A 324
 None
 1.11A 2ij7C-1e5mA:
undetectable		 2ij7C-1e5mA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv0 MALATE DEHYDROGENASE

(Chlorobaculum
tepidum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 THR A   4
VAL A  29
ALA A  65
ARG A 104
 None
 1.17A 2ij7C-1gv0A:
0.0		 2ij7C-1gv0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpw TRANSCRIPTIONAL
REGULATOR QACR

(Staphylococcus
aureus) 		PF00440
(TetR_N)
PF08360
(TetR_C_5) 		4 THR A 161
VAL A 160
ASN A  83
ALA A 153
 None
 1.15A 2ij7C-1rpwA:
0.0		 2ij7C-1rpwA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		4 THR A 248
VAL A 247
VAL A 225
ALA A 144
 None
 0.85A 2ij7C-1td2A:
0.0		 2ij7C-1td2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6a L-LACTATE
DEHYDROGENASE A
CHAIN

(Cyprinus carpio) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 THR A  95
VAL A 136
ASN A 164
ALA A 257
 None
 0.96A 2ij7C-1v6aA:
0.0		 2ij7C-1v6aA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wh7 ZF-HD HOMEOBOX
FAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 THR A  58
PHE A  35
ALA A  50
ARG A  38
 None
 1.02A 2ij7C-1wh7A:
undetectable		 2ij7C-1wh7A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		4 THR A 102
VAL A 103
VAL A  82
ALA A  23
 None
 0.92A 2ij7C-1x0uA:
undetectable		 2ij7C-1x0uA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI

(Homo sapiens) 		PF00106
(adh_short) 		4 THR A 195
VAL A 163
ASN A 114
ALA A 187
 None
 0.91A 2ij7C-1yb1A:
undetectable		 2ij7C-1yb1A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 VAL A 170
ASN A 172
ALA A 177
GLN A 260
 None
 0.99A 2ij7C-1yb4A:
undetectable		 2ij7C-1yb4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 THR A 274
VAL A 243
ALA A 211
ARG A 130
 None
None
None
SRM  A 569 (-4.2A)
 1.16A 2ij7C-1zj9A:
undetectable		 2ij7C-1zj9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C) 		4 THR A 170
ASN A 330
ALA A  30
GLN A  42
 None
 1.01A 2ij7C-1zvuA:
undetectable		 2ij7C-1zvuA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 VAL A 774
ASN A 772
ALA A 703
ARG A 513
 None
 0.93A 2ij7C-2a3lA:
undetectable		 2ij7C-2a3lA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 VAL B 252
ASN B 250
ALA B 262
GLN B 373
 None
 1.15A 2ij7C-2amcB:
undetectable		 2ij7C-2amcB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		4 VAL C 633
VAL B 427
ALA C 619
ARG A  97
 None
None
None
FAD  A 801 (-3.7A)
 1.10A 2ij7C-2e1mC:
undetectable		 2ij7C-2e1mC:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		4 VAL A 110
PHE A 124
ALA A  97
GLN A 121
 None
 1.15A 2ij7C-2g0tA:
undetectable		 2ij7C-2g0tA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS28

(Saccharomyces
cerevisiae) 		PF03997
(VPS28) 		4 THR A 192
VAL A 191
ASN A 159
PHE A 196
 None
 1.17A 2ij7C-2g3kA:
undetectable		 2ij7C-2g3kA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0s AROMATIC AMINE
DEHYDROGENASE

(Alcaligenes
faecalis) 		PF06433
(Me-amine-dh_H) 		4 THR A 249
VAL A 228
PHE A 300
ALA A 286
 None
 1.14A 2ij7C-2i0sA:
undetectable		 2ij7C-2i0sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 VAL A 227
ASN A 220
PHE A 249
ALA A 300
 None
 1.18A 2ij7C-2oajA:
undetectable		 2ij7C-2oajA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4q UPF0366 PROTEIN
C11ORF67

(Homo sapiens) 		PF04430
(DUF498) 		4 THR A  64
VAL A 114
ASN A 105
ALA A 100
 None
 1.18A 2ij7C-2q4qA:
undetectable		 2ij7C-2q4qA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v65 L-LACTATE
DEHYDROGENASE A
CHAIN

(Champsocephalus
gunnari) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 THR A  97
VAL A 138
ASN A 166
ALA A 255
 None
 0.94A 2ij7C-2v65A:
undetectable		 2ij7C-2v65A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v91 STRICTOSIDINE
SYNTHASE

(Rauvolfia
serpentina) 		PF03088
(Str_synth) 		4 THR A 154
ASN A 259
ALA A 216
ARG A 158
 None
 1.10A 2ij7C-2v91A:
undetectable		 2ij7C-2v91A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		4 THR A  53
VAL A 108
ASN A 216
ALA A 236
 None
 1.13A 2ij7C-2xfbA:
undetectable		 2ij7C-2xfbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		4 THR B 479
VAL B 482
ASN B 483
ALA B 440
 None
 0.97A 2ij7C-2xwuB:
undetectable		 2ij7C-2xwuB:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5k INTERLEUKIN-5

(Mus musculus) 		PF02025
(IL5) 		4 THR A  64
VAL A  65
VAL A  60
ALA A  23
 None
 1.08A 2ij7C-3b5kA:
undetectable		 2ij7C-3b5kA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 VAL A 253
ASN A 268
PHE A 310
ALA A 312
 None
 1.08A 2ij7C-3bgaA:
undetectable		 2ij7C-3bgaA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 THR A 235
VAL A 181
ASN A 218
ALA A 223
 None
 0.78A 2ij7C-3blwA:
undetectable		 2ij7C-3blwA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 VAL A  58
ASN A  60
ALA A  84
GLN A  69
 None
 1.09A 2ij7C-3breA:
undetectable		 2ij7C-3breA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF01715
(IPPT) 		4 THR A 103
VAL A 100
PHE A  79
ALA A  83
 None
 1.11A 2ij7C-3crrA:
undetectable		 2ij7C-3crrA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hui FERREDOXIN

(Rhodopseudomonas
palustris) 		PF00111
(Fer2) 		4 THR A 100
VAL A  50
PHE A   5
ALA A  26
 None
 1.18A 2ij7C-3huiA:
undetectable		 2ij7C-3huiA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		4 THR A 355
VAL A 354
VAL A 300
ALA A  63
 None
 0.93A 2ij7C-3hutA:
undetectable		 2ij7C-3hutA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		4 THR A 239
VAL A 248
VAL A 257
ARG A 329
 None
None
None
GOA  A 370 ( 3.1A)
 1.17A 2ij7C-3if9A:
undetectable		 2ij7C-3if9A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0b PREDICTED
N6-ADENINE-SPECIFIC
DNA METHYLASE

(Listeria
monocytogenes) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 THR A 186
VAL A 337
ASN A 303
PHE A 194
 None
 1.09A 2ij7C-3k0bA:
undetectable		 2ij7C-3k0bA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9i BH0479 PROTEIN

(Bacillus
halodurans) 		PF12688
(TPR_5) 		4 VAL A 101
ASN A  99
GLN A 126
ARG A 123
 None
 1.10A 2ij7C-3k9iA:
undetectable		 2ij7C-3k9iA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 THR A 334
VAL A 364
PHE A 308
ALA A 372
 None
 1.16A 2ij7C-3kbhA:
undetectable		 2ij7C-3kbhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lda DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 THR A 355
VAL A 323
ALA A 320
GLN A 311
 None
 1.16A 2ij7C-3ldaA:
undetectable		 2ij7C-3ldaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 THR A 200
VAL A 220
ASN A 218
PHE A 313
 None
 1.10A 2ij7C-3p1vA:
undetectable		 2ij7C-3p1vA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)

(Mycobacterium
tuberculosis) 		PF03602
(Cons_hypoth95) 		4 VAL A 149
VAL A 147
PHE A  33
ALA A  61
 None
 1.06A 2ij7C-3p9nA:
undetectable		 2ij7C-3p9nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		4 THR A  34
VAL A  94
PHE A  65
ALA A 102
 None
 0.93A 2ij7C-3pjaA:
undetectable		 2ij7C-3pjaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 THR A 330
VAL A 333
VAL A  32
ASN A 391
 None
 1.17A 2ij7C-3w9hA:
undetectable		 2ij7C-3w9hA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		4 THR A 299
VAL A 282
ASN A 295
ALA A 534
 None
 1.05A 2ij7C-3x3yA:
undetectable		 2ij7C-3x3yA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 THR A 618
VAL A 621
VAL A 623
ASN A 628
 None
 1.15A 2ij7C-3zzwA:
undetectable		 2ij7C-3zzwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 THR D 185
VAL D 218
VAL D  98
ARG D 295
 None
 0.74A 2ij7C-4b2qD:
undetectable		 2ij7C-4b2qD:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 THR A 363
VAL A 350
VAL A 344
ALA A 401
 None
 0.97A 2ij7C-4bp8A:
undetectable		 2ij7C-4bp8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00043
(GST_C) 		4 THR A  32
VAL A   5
VAL A   9
ALA A 185
 None
 1.18A 2ij7C-4bvxA:
undetectable		 2ij7C-4bvxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 THR P 647
VAL P 611
PHE P 581
ALA P 583
 None
 1.17A 2ij7C-4crnP:
undetectable		 2ij7C-4crnP:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 VAL A  55
ASN A  54
PHE A  79
ALA A  37
 None
 0.88A 2ij7C-4ewtA:
undetectable		 2ij7C-4ewtA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio cholerae) 		PF00496
(SBP_bac_5) 		4 THR A 407
VAL A 404
ASN A 251
ALA A 396
 None
 1.16A 2ij7C-4gf8A:
undetectable		 2ij7C-4gf8A:
23.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		8 THR A  77
VAL A  78
VAL A  83
ASN A  85
PHE A 168
ALA A 233
GLN A 385
ARG A 386
 None
None
1ED  A 406 (-3.6A)
1ED  A 406 (-3.7A)
1ED  A 406 (-4.1A)
HEM  A 405 ( 3.8A)
1ED  A 406 ( 4.8A)
1ED  A 406 ( 4.6A)
 0.49A 2ij7C-4ictA:
66.5		 2ij7C-4ictA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io6 AVGLUR1 LIGAND
BINDING DOMAIN

(Adineta vaga) 		PF00497
(SBP_bac_3) 		4 VAL A  18
VAL A 187
ASN A 190
GLN A 163
 None
 1.14A 2ij7C-4io6A:
undetectable		 2ij7C-4io6A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix8 TYROSINE
AMINOTRANSFERASE

(Leishmania
infantum) 		PF00155
(Aminotran_1_2) 		4 THR A 424
VAL A 431
ASN A 433
ALA A 353
 None
 0.97A 2ij7C-4ix8A:
undetectable		 2ij7C-4ix8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 THR A 438
VAL A 456
VAL A 452
ARG A 463
 None
 0.87A 2ij7C-4jklA:
undetectable		 2ij7C-4jklA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		4 THR A 298
VAL A 187
ALA A 155
GLN A 194
 None
 1.17A 2ij7C-4kpoA:
undetectable		 2ij7C-4kpoA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Conexibacter
woesei) 		PF13407
(Peripla_BP_4) 		4 THR A 265
VAL A 284
ALA A 161
GLN A 189
 None
 1.06A 2ij7C-4kq9A:
undetectable		 2ij7C-4kq9A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL A 379
ASN A 300
ALA A 355
GLN A 386
 None
K  A 501 (-3.8A)
None
None
 0.94A 2ij7C-4ls5A:
undetectable		 2ij7C-4ls5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL A 379
VAL A 330
ALA A 355
GLN A 386
 None
 0.98A 2ij7C-4ls5A:
undetectable		 2ij7C-4ls5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		PF00793
(DAHP_synth_1) 		4 THR A  51
VAL A  50
ASN A 262
ALA A 244
 None
 1.09A 2ij7C-4lu0A:
undetectable		 2ij7C-4lu0A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		4 THR A 718
VAL A 730
PHE A 672
ALA A 684
 None
 1.13A 2ij7C-4pjuA:
undetectable		 2ij7C-4pjuA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q60 PROLINE RACEMASE

(Burkholderia
multivorans) 		PF05544
(Pro_racemase) 		4 VAL A 225
ASN A 163
ALA A 243
GLN A 262
 None
 1.18A 2ij7C-4q60A:
undetectable		 2ij7C-4q60A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 VAL A 589
ASN A 591
ALA A 739
ARG A 673
 None
 1.00A 2ij7C-4xhjA:
undetectable		 2ij7C-4xhjA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y89 CARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 7

(Homo sapiens) 		PF07686
(V-set) 		4 THR A  89
VAL A  22
ASN A   4
ALA A   1
 None
 1.07A 2ij7C-4y89A:
undetectable		 2ij7C-4y89A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yte H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ0715

(Methanocaldococcus
jannaschii) 		no annotation 4 THR A 192
VAL A 191
ASN A 176
ALA A 170
 None
 1.16A 2ij7C-4yteA:
undetectable		 2ij7C-4yteA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg5 5'-NUCLEOTIDASE SURE

(Brucella
abortus) 		no annotation 4 VAL D 175
PHE D 167
ALA D 145
GLN D 125
 None
 0.99A 2ij7C-4zg5D:
undetectable		 2ij7C-4zg5D:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		4 VAL A  33
VAL A 112
ALA A 128
GLN A  95
 None
 1.03A 2ij7C-4zi5A:
undetectable		 2ij7C-4zi5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4g SILB, SILVER EFFLUX
PROTEIN, MFP
COMPONENT OF THE
THREE COMPONENTS
PROTON ANTIPORTER
METAL EFFLUX SYSTEM

(Cupriavidus
metallidurans) 		no annotation 4 VAL A 149
VAL A  79
ALA A  19
GLN A 146
 None
 1.13A 2ij7C-5a4gA:
undetectable		 2ij7C-5a4gA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		4 VAL A 373
VAL A 390
ASN A 392
ALA A 363
 None
 0.95A 2ij7C-5axhA:
undetectable		 2ij7C-5axhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		4 VAL B 115
VAL B 191
PHE B 101
ALA B 156
 None
 1.13A 2ij7C-5b47B:
undetectable		 2ij7C-5b47B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		4 THR B  35
VAL B  38
VAL B  40
ALA B  27
 None
 1.08A 2ij7C-5b48B:
undetectable		 2ij7C-5b48B:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		4 THR A 146
ASN A 142
PHE A 265
ALA A 221
 None
 0.97A 2ij7C-5csuA:
undetectable		 2ij7C-5csuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 VAL A 445
VAL A 457
PHE A 407
ALA A 380
 VAL  A 445 ( 0.6A)
VAL  A 457 ( 0.6A)
PHE  A 407 ( 1.3A)
ALA  A 380 ( 0.0A)
 1.16A 2ij7C-5d7wA:
undetectable		 2ij7C-5d7wA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		4 THR B 515
VAL B 522
ALA B 593
ARG B 573
 None
 0.92A 2ij7C-5d9aB:
undetectable		 2ij7C-5d9aB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF03358
(FMN_red) 		4 VAL A   3
PHE A 110
ALA A  18
GLN A 184
 None
 1.12A 2ij7C-5f12A:
undetectable		 2ij7C-5f12A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASN A 481
PHE A 546
ALA A 509
GLN A 514
 None
 1.13A 2ij7C-5f7cA:
undetectable		 2ij7C-5f7cA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus) 		PF08241
(Methyltransf_11) 		4 THR A 235
VAL A 238
VAL A  55
ARG A  64
 TEX  A 302 ( 4.6A)
None
None
None
 0.89A 2ij7C-5gm2A:
undetectable		 2ij7C-5gm2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqq HEME-BINDING PROTEIN
2

(Homo sapiens) 		PF04832
(SOUL) 		4 THR A  86
VAL A 183
ASN A 180
ALA A 177
 None
 1.16A 2ij7C-5gqqA:
undetectable		 2ij7C-5gqqA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1d RHO GDP-DISSOCIATION
INHIBITOR 2

(Homo sapiens) 		PF02115
(Rho_GDI) 		4 VAL A 109
ASN A 174
PHE A 141
ALA A 139
 None
 1.09A 2ij7C-5h1dA:
undetectable		 2ij7C-5h1dA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 4 THR A  10
VAL A  42
ALA A  81
ARG A 212
 None
 0.97A 2ij7C-5h6oA:
undetectable		 2ij7C-5h6oA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA

(Escherichia
coli) 		PF09481
(CRISPR_Cse1) 		4 VAL A 415
PHE A 462
ALA A 482
ARG A 483
 None
 1.13A 2ij7C-5h9fA:
undetectable		 2ij7C-5h9fA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04390
(LptE)
PF04453
(OstA_C) 		4 THR A 610
PHE B 127
ALA B  96
GLN A 507
 None
 1.07A 2ij7C-5iv9A:
undetectable		 2ij7C-5iv9A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 VAL A 731
ASN A 693
PHE A 408
ALA A 708
 None
 1.08A 2ij7C-5jouA:
undetectable		 2ij7C-5jouA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqw 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		4 VAL A 306
ASN A 135
ALA A 222
GLN A 127
 None
 1.09A 2ij7C-5kqwA:
undetectable		 2ij7C-5kqwA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kr6 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		4 VAL A 306
ASN A 135
ALA A 222
GLN A 127
 None
 1.10A 2ij7C-5kr6A:
undetectable		 2ij7C-5kr6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kua PILIN

(Neisseria
meningitidis) 		PF00114
(Pilin)
PF07963
(N_methyl) 		4 THR A  48
VAL A  47
VAL A  86
ALA A  40
 None
 0.98A 2ij7C-5kuaA:
undetectable		 2ij7C-5kuaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyo CYP101J2

(Sphingobium
yanoikuyae) 		PF00067
(p450) 		4 THR A 262
VAL A 256
PHE A 291
ALA A 365
 None
None
HEM  A 501 (-4.8A)
HEM  A 501 (-3.5A)
 1.18A 2ij7C-5kyoA:
35.2		 2ij7C-5kyoA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		4 THR A 150
VAL A 282
ASN A 281
ALA A 275
 None
 1.08A 2ij7C-5mswA:
undetectable		 2ij7C-5mswA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		4 THR A 139
VAL A 181
PHE A  46
ALA A 130
 None
 1.15A 2ij7C-5ntfA:
undetectable		 2ij7C-5ntfA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obw CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 4 THR A 267
VAL A 274
VAL A 276
ALA A 224
 None
 1.13A 2ij7C-5obwA:
undetectable		 2ij7C-5obwA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0z LIPOPROTEIN,
PUTATIVE

(Geobacter
metallireducens) 		no annotation 4 THR A  59
VAL A  58
PHE A 131
ALA A 129
 None
 0.68A 2ij7C-5t0zA:
undetectable		 2ij7C-5t0zA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		4 THR A  88
VAL A 107
ASN A 109
ALA A 113
 None
 1.18A 2ij7C-5tzbA:
undetectable		 2ij7C-5tzbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 4 THR D  86
VAL D  87
VAL D 118
ALA D 122
 None
 1.04A 2ij7C-5ui3D:
undetectable		 2ij7C-5ui3D:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 4 THR A 112
VAL A 111
VAL A  50
ALA A  57
 None
 1.12A 2ij7C-5v54A:
undetectable		 2ij7C-5v54A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3

(Vicugna pacos) 		no annotation 4 THR B  78
VAL B  79
ASN B  35
ALA B  32
 None
 1.17A 2ij7C-5vxjB:
undetectable		 2ij7C-5vxjB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 THR A 494
VAL A 591
ALA A 599
GLN A 594
 None
 1.16A 2ij7C-5xb7A:
undetectable		 2ij7C-5xb7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio harveyi) 		no annotation 4 THR A 408
VAL A 405
ASN A 252
ALA A 397
 None
 1.16A 2ij7C-5yqwA:
undetectable		 2ij7C-5yqwA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 THR A 516
VAL A 515
VAL A 466
ALA A 508
 None
 1.13A 2ij7C-6c66A:
undetectable		 2ij7C-6c66A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 4 VAL A 538
ASN A 540
PHE A 455
ALA A 375
 None
 0.87A 2ij7C-6cthA:
undetectable		 2ij7C-6cthA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 4 THR A  55
VAL A  82
VAL A 126
ALA A  97
 None
 1.05A 2ij7C-6eo5A:
undetectable		 2ij7C-6eo5A:
13.39