SIMILAR PATTERNS OF AMINO ACIDS FOR 2IJ7_B_TPFB2470_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 VAL A1251
MET A1273
PHE A1209
THR A1232
ALA A1189
 None
 1.50A 2ij7B-2b39A:
0.0		 2ij7B-2b39A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		5 THR A 135
ASN A  18
MET A  17
THR A 123
ALA A 126
 THR  A 135 ( 0.8A)
ASN  A  18 ( 0.6A)
MET  A  17 ( 0.0A)
THR  A 123 ( 0.8A)
ALA  A 126 ( 0.0A)
 1.29A 2ij7B-2ogsA:
0.0		 2ij7B-2ogsA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		5 THR A 349
VAL A 350
THR A 337
ALA A 343
GLN A 233
 None
 1.35A 2ij7B-2pnwA:
0.0		 2ij7B-2pnwA:
24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		9 THR A  77
VAL A  78
ASN A  85
MET A  86
PHE A 168
THR A 229
ALA A 233
GLN A 385
ARG A 386
 None
None
1ED  A 406 (-3.7A)
HEM  A 405 (-4.5A)
1ED  A 406 (-4.1A)
1ED  A 406 (-4.3A)
HEM  A 405 ( 3.8A)
1ED  A 406 ( 4.8A)
1ED  A 406 ( 4.6A)
 0.51A 2ij7B-4ictA:
65.7		 2ij7B-4ictA:
100.00