SIMILAR PATTERNS OF AMINO ACIDS FOR 2IGT_C_SAMC1003_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0f GLUTATHIONE
S-TRANSFERASE

(Escherichia
coli) 		PF00043
(GST_C)
PF13409
(GST_N_2) 		5 HIS A 106
TYR A 157
SER A  14
ALA A  13
ALA A  74
 GTS  A 203 (-3.9A)
None
None
None
None
 1.19A 2igtC-1a0fA:
undetectable		 2igtC-1a0fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlm CATECHOL
1,2-DIOXYGENASE

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 228
ALA A 254
PRO A 108
GLY A  77
TYR A 110
 None
 1.20A 2igtC-1dlmA:
undetectable		 2igtC-1dlmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		5 ALA A  58
SER A  57
ALA A  53
ALA A  47
GLY A  49
 None
 1.31A 2igtC-1esoA:
undetectable		 2igtC-1esoA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		5 PHE A 174
PHE A 146
TYR A 143
ALA A  47
TYR A 140
 None
None
None
NEA  A 500 (-3.1A)
None
 1.31A 2igtC-1g38A:
10.0		 2igtC-1g38A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 ALA A 681
ALA A 655
ALA A 647
PRO A 703
GLY A 685
 None
 1.23A 2igtC-1h54A:
undetectable		 2igtC-1h54A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		5 HIS A  59
ALA A 104
ALA A  31
GLY A 197
TRP A  41
 None
 1.18A 2igtC-1hylA:
undetectable		 2igtC-1hylA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 HIS A 515
SER A 276
ALA A 279
ALA A 478
GLY A 476
 None
 1.12A 2igtC-1i1qA:
undetectable		 2igtC-1i1qA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbu MURAMOYL-PENTAPEPTID
E CARBOXYPEPTIDASE

(Streptomyces
albus) 		PF01471
(PG_binding_1)
PF08291
(Peptidase_M15_3) 		5 ALA A 171
ALA A 176
PRO A 187
GLY A 168
TYR A 189
 None
 1.27A 2igtC-1lbuA:
undetectable		 2igtC-1lbuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 TYR A 128
ALA A 125
ALA A 298
PRO A 135
GLY A 266
 None
 1.20A 2igtC-1lrkA:
6.8		 2igtC-1lrkA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7h ADENYLYLSULFATE
KINASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase) 		5 PHE A 133
ALA A  91
ALA A  95
ALA A 116
TYR A 199
 None
 1.26A 2igtC-1m7hA:
undetectable		 2igtC-1m7hA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A  15
ALA A  70
PRO A 184
GLY A  73
TYR A 185
 None
 0.94A 2igtC-1n8pA:
3.7		 2igtC-1n8pA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT

(Methylophilus
methylotrophus) 		PF01012
(ETF) 		5 HIS D  86
PHE D  75
ALA D 176
ALA D  81
GLY D  65
 None
 1.31A 2igtC-1o94D:
2.3		 2igtC-1o94D:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Sus scrofa) 		PF01144
(CoA_trans) 		5 PHE A 184
ALA A 188
SER A 187
ALA A 173
GLY A  29
 None
 1.30A 2igtC-1opeA:
2.9		 2igtC-1opeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 HIS A 222
PHE A  97
PHE A 157
ALA A  65
GLY A 161
 None
 1.09A 2igtC-1r3nA:
undetectable		 2igtC-1r3nA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 HIS A  21
PHE A  82
PHE A 294
ALA A 334
PRO A  28
 None
 1.29A 2igtC-1rqgA:
undetectable		 2igtC-1rqgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ALA A 532
SER A 533
ALA A 489
PRO A 515
GLY A 596
 None
 1.09A 2igtC-1sb3A:
undetectable		 2igtC-1sb3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 TYR A 158
ALA A  35
SER A  38
ALA A  49
PRO A  27
 None
 1.25A 2igtC-1urjA:
undetectable		 2igtC-1urjA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		5 PHE A 217
SER A 240
ALA A 243
ALA A 266
PRO A 288
 None
 0.45A 2igtC-1wxxA:
21.0		 2igtC-1wxxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1
PECTINESTERASE
INHIBITOR

(Solanum
lycopersicum;
Actinidia
chinensis) 		PF01095
(Pectinesterase)
PF04043
(PMEI) 		5 PHE B  91
TYR B 103
ALA A 159
SER A 138
ALA B 106
 None
 1.15A 2igtC-1xg2B:
undetectable		 2igtC-1xg2B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv2 HYPOTHETICAL
PROTEIN, SIMILAR TO
ALPHA-ACETOLACTATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF03306
(AAL_decarboxy) 		5 HIS A 208
TYR A   6
ALA A  53
GLY A  67
TYR A  73
 None
 1.14A 2igtC-1xv2A:
undetectable		 2igtC-1xv2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		5 PHE A  59
TYR A  59
ALA A  55
ALA A 104
GLY A 196
 None
 1.21A 2igtC-1zlrA:
undetectable		 2igtC-1zlrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1l PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
BETA ISOFORM

(Rattus
norvegicus) 		PF02121
(IP_trans) 		5 PHE A 229
ALA A 144
PRO A  12
GLY A 174
TYR A  18
 None
 1.25A 2igtC-2a1lA:
undetectable		 2igtC-2a1lA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		6 PHE A 201
PHE A 225
TYR A 227
ALA A 252
ALA A 276
PRO A 298
 None
 1.01A 2igtC-2as0A:
22.2		 2igtC-2as0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		5 PHE A 225
SER A 249
ALA A 252
ALA A 276
PRO A 298
 None
 0.63A 2igtC-2as0A:
22.2		 2igtC-2as0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azq CATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 224
ALA A 250
PRO A 107
GLY A  76
TYR A 109
 None
 1.12A 2igtC-2azqA:
undetectable		 2igtC-2azqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 PHE A1092
ALA A1256
ALA A1176
ALA A1263
PRO A1259
 None
 1.31A 2igtC-2bruA:
5.8		 2igtC-2bruA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		5 TYR A 452
ALA A 445
ALA A 442
ALA A 475
GLY A 446
 None
 1.15A 2igtC-2dh3A:
undetectable		 2igtC-2dh3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		5 PHE A 148
ALA A  80
ALA A 108
GLY A  77
TYR A 146
 None
 1.29A 2igtC-2fefA:
undetectable		 2igtC-2fefA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 283
SER A 281
ALA A 318
ALA A 405
TYR A 300
 None
 1.19A 2igtC-2gqdA:
undetectable		 2igtC-2gqdA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		6 HIS A 109
PHE A 140
TYR A 142
ALA A 162
ALA A 191
GLY A 218
 FMT  A1013 (-4.1A)
SAM  A1001 (-4.4A)
FMT  A1013 ( 4.7A)
SAM  A1001 (-3.5A)
SAM  A1001 (-3.6A)
SAM  A1001 (-3.7A)
 1.39A 2igtC-2igtA:
51.6		 2igtC-2igtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		11 PHE A 113
PHE A 140
TYR A 142
ALA A 162
SER A 163
ALA A 166
ALA A 191
PRO A 213
GLY A 218
TRP A 224
TYR A 253
 FMT  A1013 ( 3.5A)
SAM  A1001 (-4.4A)
FMT  A1013 ( 4.7A)
SAM  A1001 (-3.5A)
ACY  A1008 ( 2.6A)
SAM  A1001 ( 3.9A)
SAM  A1001 (-3.6A)
SAM  A1001 (-3.2A)
SAM  A1001 (-3.7A)
None
SAM  A1001 (-4.7A)
 0.08A 2igtC-2igtA:
51.6		 2igtC-2igtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 PHE A 733
TYR A 308
SER A 301
ALA A 304
ALA A 200
 None
 1.25A 2igtC-2pi5A:
undetectable		 2igtC-2pi5A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q74 INOSITOL-1-MONOPHOSP
HATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		5 ALA A 147
SER A 146
ALA A 135
PRO A   8
GLY A 152
 None
 1.29A 2igtC-2q74A:
undetectable		 2igtC-2q74A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		5 ALA A 108
ALA A 310
PRO A 240
GLY A 198
TYR A 238
 None
HEM  A 410 ( 3.7A)
HEM  A 410 ( 4.2A)
HEM  A 410 (-3.1A)
None
 0.95A 2igtC-2rfbA:
undetectable		 2igtC-2rfbA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 TYR A 260
SER A 165
ALA A 401
ALA A 344
GLY A 340
 None
 1.16A 2igtC-2rjtA:
undetectable		 2igtC-2rjtA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 ALA A 693
SER A 694
ALA A 502
PRO A 751
GLY A 692
 None
 1.19A 2igtC-2wdaA:
undetectable		 2igtC-2wdaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqk 5'-NUCLEOTIDASE SURE

(Aquifex
aeolicus) 		PF01975
(SurE) 		5 PHE A 135
ALA A  23
ALA A 127
PRO A  15
GLY A  92
 None
 1.30A 2igtC-2wqkA:
3.0		 2igtC-2wqkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 PHE A 239
ALA A 452
SER A 448
ALA A 456
GLY A 451
 None
None
BGC  A1526 ( 4.9A)
None
None
 1.23A 2igtC-2wzfA:
undetectable		 2igtC-2wzfA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 PHE A 239
ALA A 452
SER A 448
ALA A 456
GLY A 451
 None
None
UPG  A1525 ( 4.9A)
None
None
 1.23A 2igtC-2wzgA:
undetectable		 2igtC-2wzgA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsr CATECHOL 1,2
DIOXYGENASE

(Acinetobacter
radioresistens) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 223
ALA A 249
PRO A 104
GLY A  73
TYR A 106
 None
 1.13A 2igtC-2xsrA:
undetectable		 2igtC-2xsrA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 PHE A 159
PHE A 150
ALA A 124
ALA A 128
PRO A 370
 None
 1.19A 2igtC-3a05A:
2.3		 2igtC-3a05A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 PHE A  64
ALA A  65
SER A  61
ALA A  14
GLY A  66
 None
 1.27A 2igtC-3a2qA:
undetectable		 2igtC-3a2qA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A  63
SER A  64
ALA A 165
ALA A  94
TYR A  50
 None
 1.08A 2igtC-3a9vA:
undetectable		 2igtC-3a9vA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		5 PHE A 216
TYR A 217
ALA A  89
SER A  87
ALA A 229
 None
PLP  A 500 ( 4.7A)
None
PLP  A 500 (-2.5A)
None
 1.21A 2igtC-3bb8A:
3.0		 2igtC-3bb8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		5 ALA A  19
SER A  20
ALA A  10
PRO A 138
GLY A  14
 None
 1.13A 2igtC-3bczA:
2.3		 2igtC-3bczA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goh ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Shewanella
oneidensis) 		PF08240
(ADH_N) 		5 PHE A  97
ALA A 152
ALA A 122
PRO A  42
GLY A 151
 None
 1.27A 2igtC-3gohA:
6.6		 2igtC-3gohA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		5 TYR A 128
ALA A 112
SER A  87
PRO A 124
GLY A  90
 EVS  A1000 (-3.7A)
None
EVS  A1000 (-1.4A)
None
None
 1.26A 2igtC-3gzjA:
2.4		 2igtC-3gzjA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		5 PHE A  43
PHE A  85
ALA A  50
ALA A 128
GLY A  64
 None
 1.08A 2igtC-3h9pA:
undetectable		 2igtC-3h9pA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 PHE 3 740
ALA 3 762
SER 3 761
ALA 3 714
ALA 3 766
 None
 1.18A 2igtC-3i9v3:
2.4		 2igtC-3i9v3:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		5 ALA A 319
ALA A 301
ALA A 321
PRO A 243
GLY A 318
 None
None
None
None
LLP  A  91 ( 4.4A)
 1.23A 2igtC-3iauA:
3.2		 2igtC-3iauA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvd TRANSCRIPTIONAL
REGULATORS

(Corynebacterium
glutamicum) 		PF13377
(Peripla_BP_3) 		5 HIS A 325
ALA A 205
ALA A 234
ALA A 199
GLY A 204
 None
 1.22A 2igtC-3jvdA:
4.4		 2igtC-3jvdA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		5 PHE B 455
ALA B  67
ALA B  69
PRO B  49
GLY B  66
 None
 1.31A 2igtC-3ml0B:
undetectable		 2igtC-3ml0B:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ALA A 225
SER A 226
ALA A 233
ALA B 187
PRO B 279
 SRM  B 570 ( 4.0A)
None
None
None
None
 1.20A 2igtC-3mm5A:
undetectable		 2igtC-3mm5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 233
SER A 335
ALA A 339
GLY A  50
TYR A 223
 None
 1.08A 2igtC-3oytA:
undetectable		 2igtC-3oytA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qef BETA-XYLOSIDASE/ALPH
A-L-ARABINFURANOSIDA
SE, GLY43N

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		5 PHE A 129
ALA A  98
ALA A 150
GLY A 100
TRP A 103
 None
None
None
None
EDO  A 336 (-3.5A)
 1.25A 2igtC-3qefA:
undetectable		 2igtC-3qefA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		5 PHE A 127
TYR A 126
ALA A   7
PRO A 128
GLY A  97
 None
None
NDP  A1001 ( 4.1A)
None
NDP  A1001 ( 3.8A)
 1.21A 2igtC-3tq9A:
undetectable		 2igtC-3tq9A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 HIS A 381
ALA A 353
SER A 231
GLY A 439
TYR A 519
 None
ACT  A 702 (-4.4A)
MG  A 701 ( 1.9A)
ACT  A 702 (-4.1A)
None
 1.13A 2igtC-3tw0A:
2.4		 2igtC-3tw0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 PHE A 523
PHE A 546
TYR A 548
SER A 570
PRO A 617
 None
SAM  A 802 (-4.5A)
SAM  A 802 (-4.7A)
None
SAM  A 802 ( 4.6A)
 0.73A 2igtC-3v8vA:
22.3		 2igtC-3v8vA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A 114
ALA A 140
ALA A 157
PRO A  63
GLY A 115
 None
 1.27A 2igtC-3zz1A:
3.7		 2igtC-3zz1A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 5 PHE A 462
ALA A 494
ALA A 614
ALA A 451
GLY A 495
 None
 1.03A 2igtC-4a7kA:
undetectable		 2igtC-4a7kA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 TYR A 282
ALA A 299
ALA A 303
ALA A 381
GLY A 295
 None
 1.29A 2igtC-4c2kA:
undetectable		 2igtC-4c2kA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c89 ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		5 PHE A 156
TYR A 158
ALA A  80
ALA A 183
GLY A 148
 None
 1.27A 2igtC-4c89A:
3.1		 2igtC-4c89A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		5 TYR A 300
ALA A 294
SER A 295
GLY A 290
TRP A 458
 None
 1.00A 2igtC-4f7aA:
undetectable		 2igtC-4f7aA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A  91
SER A  67
ALA A 115
ALA A  85
GLY A  90
 None
 1.20A 2igtC-4isbA:
3.2		 2igtC-4isbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 HIS A 920
ALA A 818
ALA A 875
GLY A 819
TYR A 865
 None
 1.30A 2igtC-4j3bA:
undetectable		 2igtC-4j3bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 TYR A 346
ALA A 235
SER A 201
ALA A 345
GLY A 237
 None
 1.23A 2igtC-4kg7A:
2.3		 2igtC-4kg7A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 PHE A 443
ALA A 437
SER A 438
ALA A 440
GLY A 436
 None
 1.26A 2igtC-4knaA:
3.4		 2igtC-4knaA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 PHE A 329
PHE A 324
SER A 116
ALA A 312
GLY A 319
 AG8  A 901 (-3.7A)
None
None
None
None
 1.30A 2igtC-4lixA:
undetectable		 2igtC-4lixA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsu HEAVY CHAIN OF
ANTIBODY VRC-PG20
LIGHT CHAIN OF
ANTIBODY VRC-PG20

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 PHE H 100
ALA L  26
SER L  27
ALA L  71
GLY L  25
 None
 1.16A 2igtC-4lsuH:
undetectable		 2igtC-4lsuH:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		5 SER A 485
ALA A 531
ALA A 604
GLY A 576
TYR A 523
 None
EDO  A 702 (-3.5A)
None
None
None
 1.18A 2igtC-4ni2A:
undetectable		 2igtC-4ni2A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7i 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		5 HIS A 258
PHE A 282
ALA A 235
ALA A 296
ALA A 168
 None
 1.24A 2igtC-4o7iA:
undetectable		 2igtC-4o7iA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1

(Sicarius
terrosus) 		no annotation 5 PHE A 166
PHE A 145
ALA A 107
ALA A 102
ALA A 110
 None
 1.23A 2igtC-4q6xA:
2.2		 2igtC-4q6xA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 HIS A 255
PHE A  53
TYR A 539
ALA A 544
PRO A 146
 None
 1.23A 2igtC-4r1dA:
undetectable		 2igtC-4r1dA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 PHE A1121
TYR A1120
SER A1141
ALA A1160
GLY A1145
 None
 1.27A 2igtC-4s0vA:
undetectable		 2igtC-4s0vA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 PHE L 489
TYR L 484
ALA L 480
GLY L 506
TRP L 450
 None
 1.23A 2igtC-4tkxL:
3.1		 2igtC-4tkxL:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		5 TYR A 188
ALA A 234
ALA A 340
GLY A 184
TYR A 221
 None
 1.13A 2igtC-4u9cA:
undetectable		 2igtC-4u9cA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		5 ALA A  45
SER A  43
ALA A 160
GLY A 307
TYR A 177
 FAD  A 401 ( 4.5A)
FAD  A 401 (-2.3A)
None
FAD  A 401 ( 4.1A)
None
 1.22A 2igtC-4yshA:
3.4		 2igtC-4yshA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 PHE A 475
TYR A 465
ALA A 461
ALA A 280
GLY A 370
 None
 1.21A 2igtC-4zi6A:
2.3		 2igtC-4zi6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5agt LEUCINE--TRNA LIGASE

(Mycobacterium
tuberculosis) 		PF13603
(tRNA-synt_1_2) 		5 PHE A 318
PHE A 426
ALA A 454
PRO A 424
GLY A 458
 None
None
None
GOL  A1515 ( 4.9A)
None
 1.21A 2igtC-5agtA:
undetectable		 2igtC-5agtA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		5 ALA B 165
ALA B 189
PRO B 224
GLY B 253
TRP B 222
 None
 1.08A 2igtC-5b47B:
4.1		 2igtC-5b47B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 PHE A 324
ALA A 267
ALA A 394
GLY A 271
TYR A 229
 None
 1.30A 2igtC-5b4wA:
undetectable		 2igtC-5b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5civ SIBLING BACTERIOCIN

(Paenibacillus
dendritiformis) 		PF08020
(DUF1706) 		5 PHE A 170
TYR A  63
ALA A 105
SER A 102
ALA A 108
 None
 1.21A 2igtC-5civA:
undetectable		 2igtC-5civA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A  76
TYR A  99
ALA A 238
ALA A 236
GLY A 194
 None
 1.26A 2igtC-5e6kA:
undetectable		 2igtC-5e6kA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A  76
TYR A  99
ALA A 238
ALA A 236
GLY A 194
 None
 1.27A 2igtC-5enyA:
undetectable		 2igtC-5enyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		5 PHE A 415
TYR A 416
ALA A 411
ALA A 464
GLY A 558
 None
 1.19A 2igtC-5eodA:
undetectable		 2igtC-5eodA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm3 ENDOGLUCANASE-1

(Aspergillus
aculeatus) 		PF01670
(Glyco_hydro_12) 		5 ALA A 209
PRO A 203
GLY A 207
TRP A  53
TYR A  63
 None
 1.27A 2igtC-5gm3A:
undetectable		 2igtC-5gm3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ALA B 915
SER B 866
ALA B 884
ALA B 926
GLY B 924
 None
 1.15A 2igtC-5jpnB:
undetectable		 2igtC-5jpnB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ALA B 915
SER B 866
ALA B 884
ALA B 926
GLY B 924
 None
 1.13A 2igtC-5jtwB:
undetectable		 2igtC-5jtwB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ALA A 207
SER A 208
ALA A 350
ALA A 497
GLY A 222
 None
 1.22A 2igtC-5kxjA:
undetectable		 2igtC-5kxjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 PHE A 432
TYR A 386
ALA A 389
ALA A  86
GLY A  30
 None
 1.08A 2igtC-5kznA:
2.6		 2igtC-5kznA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 5 TYR C  55
ALA C 348
SER C 349
GLY C 212
TYR C  63
 None
None
13X  C 500 (-4.2A)
None
None
 1.27A 2igtC-5mg5C:
undetectable		 2igtC-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		5 ALA A 684
SER A 685
ALA A 687
ALA A 678
GLY A 683
 None
 1.26A 2igtC-5mswA:
5.4		 2igtC-5mswA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 5 PHE A 353
TYR A  79
ALA A 310
GLY A 165
TYR A  92
 None
 1.21A 2igtC-5ngjA:
undetectable		 2igtC-5ngjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td3 CATECHOL
1,2-DIOXYGENASE

(Burkholderia
vietnamiensis) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 239
ALA A 265
PRO A 119
GLY A  88
TYR A 121
 None
 1.13A 2igtC-5td3A:
undetectable		 2igtC-5td3A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umh CATECHOL
1,2-DIOXYGENASE

(Burkholderia
multivorans) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 228
ALA A 254
PRO A 108
GLY A  77
TYR A 110
 None
None
EDO  A 402 (-4.4A)
None
None
 1.12A 2igtC-5umhA:
undetectable		 2igtC-5umhA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE

(Streptomyces
ribosidificus) 		PF01041
(DegT_DnrJ_EryC1) 		5 PHE A  57
TYR A  53
SER A 259
ALA A 211
GLY A 209
 None
 1.12A 2igtC-5w70A:
2.9		 2igtC-5w70A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 5 PHE A 228
ALA A 204
SER A 203
ALA A  73
GLY A 209
 None
None
C6P  A 502 (-2.4A)
C6P  A 502 (-3.8A)
None
 1.14A 2igtC-5wt4A:
3.6		 2igtC-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 5 TYR A 146
ALA A 185
SER A 186
GLY A 182
TYR A 112
 GOL  A1006 ( 4.8A)
None
CL  A1008 ( 4.5A)
None
None
 1.24A 2igtC-5y0mA:
undetectable		 2igtC-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 ANTIBODY FAB HEAVY
CHAIN

(Mus musculus) 		no annotation 5 PHE A  70
ALA A  92
ALA A  90
GLY A  40
TYR A  60
 None
 1.01A 2igtC-6c08A:
undetectable		 2igtC-6c08A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 5 HIS A  81
PHE A  45
TYR A  14
ALA A  12
PRO A  43
 None
 1.20A 2igtC-6gnfA:
2.8		 2igtC-6gnfA:
undetectable