SIMILAR PATTERNS OF AMINO ACIDS FOR 2IGT_B_SAMB1002_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp2 NITROGENASE IRON
PROTEIN

(Clostridium
pasteurianum) 		PF00142
(Fer4_NifH) 		5 TYR A 121
ALA A 133
ALA A 141
GLY A  96
GLY A 130
 None
 1.11A 2igtB-1cp2A:
undetectable		 2igtB-1cp2A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 ALA A 293
SER A 269
ALA A 211
GLY A 314
GLY A 292
 None
 1.08A 2igtB-1dabA:
undetectable		 2igtB-1dabA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlj UDP-GLUCOSE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ALA A 216
PRO A 262
GLY A 257
GLY A 255
TYR A  85
 None
None
UGA  A 404 (-3.2A)
None
None
 1.09A 2igtB-1dljA:
4.9		 2igtB-1dljA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A  93
ALA A 273
ALA A 298
GLY A 208
GLY A 203
 None
NAI  A 377 ( 3.9A)
None
None
NAI  A 377 (-3.4A)
 1.15A 2igtB-1e3eA:
7.3		 2igtB-1e3eA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		5 PHE A 452
ALA A 420
ALA A 417
GLY A 351
GLY A 349
 None
 1.05A 2igtB-1hcuA:
undetectable		 2igtB-1hcuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqa TAS PROTEIN

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		5 PHE A 141
ALA A  85
SER A  86
ALA A  50
GLY A 177
 NDP  A1400 ( 4.8A)
None
None
None
None
 1.07A 2igtB-1lqaA:
undetectable		 2igtB-1lqaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A  15
ALA A  70
PRO A 184
GLY A  73
TYR A 185
 None
 0.98A 2igtB-1n8pA:
3.5		 2igtB-1n8pA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		5 TYR A 339
ALA A 333
SER A 334
ALA A 338
GLY A 302
 None
None
None
None
ACT  A 505 (-3.0A)
 1.08A 2igtB-1pjqA:
5.9		 2igtB-1pjqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn9 GLUTATHIONE
S-TRANSFERASE 1-6

(Anopheles
gambiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 PHE A 117
ALA A 164
ALA A 169
ALA A 161
GLY A 199
 None
 0.99A 2igtB-1pn9A:
undetectable		 2igtB-1pn9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ALA A 532
SER A 533
ALA A 489
PRO A 515
GLY A 596
 None
 1.10A 2igtB-1sb3A:
undetectable		 2igtB-1sb3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		5 PHE A  23
ALA A  10
SER A  11
ALA A  49
GLY A 245
 None
 1.08A 2igtB-1tdhA:
undetectable		 2igtB-1tdhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		5 ALA A 158
ALA A 142
ALA A 156
GLY A 193
GLY A 189
 None
 0.90A 2igtB-1uc4A:
undetectable		 2igtB-1uc4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT
2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		6 PHE A 228
PHE A 189
ALA A 197
GLY B  65
GLY B  69
TYR A 184
 None
 1.40A 2igtB-1umbA:
3.2		 2igtB-1umbA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		5 PHE A 217
SER A 240
ALA A 243
ALA A 266
PRO A 288
 None
 0.43A 2igtB-1wxxA:
21.2		 2igtB-1wxxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1
PECTINESTERASE
INHIBITOR

(Solanum
lycopersicum;
Actinidia
chinensis) 		PF01095
(Pectinesterase)
PF04043
(PMEI) 		5 PHE B  91
TYR B 103
ALA A 159
SER A 138
ALA B 106
 None
 1.15A 2igtB-1xg2B:
undetectable		 2igtB-1xg2B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 HYPOTHETICAL PROTEIN
PH1363

(Pyrococcus
horikoshii) 		PF07992
(Pyr_redox_2)
PF13510
(Fer2_4) 		5 TYR A 369
ALA A 121
ALA A 368
GLY A 348
GLY A 118
 None
None
None
ATP  A 801 (-3.1A)
None
 1.03A 2igtB-1y56A:
2.9		 2igtB-1y56A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 SER A 633
ALA A 484
ALA A 636
GLY A 572
GLY A 631
 None
 1.14A 2igtB-1zjkA:
undetectable		 2igtB-1zjkA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		5 TYR A 631
ALA A 637
ALA A 325
PRO A 617
GLY A 305
 None
 1.16A 2igtB-2a3lA:
undetectable		 2igtB-2a3lA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		6 PHE A 201
PHE A 225
TYR A 227
ALA A 252
ALA A 276
PRO A 298
 None
 0.99A 2igtB-2as0A:
22.4		 2igtB-2as0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		5 PHE A 225
SER A 249
ALA A 252
ALA A 276
PRO A 298
 None
 0.60A 2igtB-2as0A:
22.4		 2igtB-2as0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 PHE A 430
ALA A 284
ALA A 405
GLY A 450
GLY A 452
 None
 1.14A 2igtB-2aw5A:
4.5		 2igtB-2aw5A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azq CATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 224
ALA A 250
PRO A 107
GLY A  76
TYR A 109
 None
 1.15A 2igtB-2azqA:
undetectable		 2igtB-2azqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azq CATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 224
PRO A 107
GLY A  71
GLY A  76
TYR A 109
 None
 1.16A 2igtB-2azqA:
undetectable		 2igtB-2azqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		6 TYR A 452
ALA A 445
ALA A 442
ALA A 475
GLY A 448
GLY A 446
 None
 1.25A 2igtB-2dh3A:
undetectable		 2igtB-2dh3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 PHE A 335
ALA A 244
SER A 243
ALA A 204
GLY A 248
 None
 1.08A 2igtB-2e0pA:
undetectable		 2igtB-2e0pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 PHE A 113
ALA A 275
SER A 116
GLY A 269
GLY A 265
 None
None
PMP  A1001 (-3.7A)
None
None
 1.15A 2igtB-2e7uA:
3.0		 2igtB-2e7uA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ALA A 460
ALA A 209
GLY A  34
GLY A 456
TYR A 171
 None
 1.07A 2igtB-2fjaA:
undetectable		 2igtB-2fjaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 PHE A 230
ALA A 325
ALA A 279
GLY A 404
GLY A 407
 None
 1.00A 2igtB-2gp6A:
undetectable		 2igtB-2gp6A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ALA A 106
ALA A  33
GLY A 396
GLY A  28
TYR A 374
 None
None
FAD  A1001 (-3.6A)
FAD  A1001 (-4.1A)
None
 1.06A 2igtB-2h88A:
2.7		 2igtB-2h88A:
18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		12 PHE A 113
PHE A 140
TYR A 142
ALA A 162
SER A 163
ALA A 166
ALA A 191
PRO A 213
GLY A 216
GLY A 218
TRP A 224
TYR A 253
 FMT  A1013 ( 3.5A)
SAM  A1001 (-4.4A)
FMT  A1013 ( 4.7A)
SAM  A1001 (-3.5A)
ACY  A1008 ( 2.6A)
SAM  A1001 ( 3.9A)
SAM  A1001 (-3.6A)
SAM  A1001 (-3.2A)
SAM  A1001 (-3.5A)
SAM  A1001 (-3.7A)
None
SAM  A1001 (-4.7A)
 0.13A 2igtB-2igtA:
52.2		 2igtB-2igtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 ALA G 280
ALA G 299
ALA G 158
GLY G 161
GLY G 272
 None
 1.08A 2igtB-2uv8G:
undetectable		 2igtB-2uv8G:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzp CAMELID VHH5

(Lama glama) 		PF07686
(V-set) 		5 ALA D  98
ALA D  50
ALA D  24
GLY D 114
GLY D 112
 None
 1.06A 2igtB-2wzpD:
undetectable		 2igtB-2wzpD:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsr CATECHOL 1,2
DIOXYGENASE

(Acinetobacter
radioresistens) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 223
ALA A 249
PRO A 104
GLY A  73
TYR A 106
 None
 1.16A 2igtB-2xsrA:
undetectable		 2igtB-2xsrA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 TYR A 413
ALA A 398
ALA A 309
GLY A 293
GLY A 395
 None
 1.02A 2igtB-2z0fA:
undetectable		 2igtB-2z0fA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		5 ALA A 230
ALA A 228
ALA A 232
GLY A 448
GLY A 445
 None
 1.05A 2igtB-2z5lA:
5.2		 2igtB-2z5lA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		5 ALA A  31
ALA A 197
ALA A  35
GLY A  39
GLY A  30
 None
 1.11A 2igtB-2z6iA:
undetectable		 2igtB-2z6iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A  63
SER A  64
ALA A 165
ALA A  94
TYR A  50
 None
 1.04A 2igtB-3a9vA:
undetectable		 2igtB-3a9vA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		5 TYR A 290
ALA A 238
PRO A 198
GLY A 188
GLY A 262
 FLC  A 356 (-4.6A)
None
None
None
None
 1.06A 2igtB-3aquA:
undetectable		 2igtB-3aquA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Chromohalobacter
salexigens) 		PF01370
(Epimerase) 		5 PHE A 192
PHE A 107
ALA A  97
GLY A  71
GLY A  89
 None
 1.03A 2igtB-3ay3A:
5.2		 2igtB-3ay3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 ALA A 267
SER A 266
ALA A 263
ALA A 372
GLY A 297
 None
 1.14A 2igtB-3b40A:
undetectable		 2igtB-3b40A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		5 ALA A  19
SER A  20
ALA A  10
PRO A 138
GLY A  14
 None
 1.13A 2igtB-3bczA:
2.2		 2igtB-3bczA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		5 ALA A 110
ALA A 112
GLY A  80
GLY A  76
TYR A 100
 None
 1.14A 2igtB-3bg2A:
undetectable		 2igtB-3bg2A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjz PHOSPHOHEPTOSE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13580
(SIS_2) 		5 ALA A 153
SER A 154
ALA A 143
GLY A 122
GLY A 149
 None
 1.08A 2igtB-3bjzA:
3.2		 2igtB-3bjzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		6 PHE A 111
PHE A 108
ALA A 103
ALA A 501
PRO A 107
GLY A 155
 None
None
ZN  A 800 ( 4.8A)
None
None
None
 1.35A 2igtB-3eh2A:
undetectable		 2igtB-3eh2A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 ALA A  12
ALA A  47
ALA A 348
GLY A 342
GLY A 335
 FAD  A 444 (-3.4A)
None
None
FAD  A 444 (-3.1A)
FAD  A 444 (-3.3A)
 1.14A 2igtB-3g5sA:
2.6		 2igtB-3g5sA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		5 PHE A  43
PHE A  85
ALA A  50
ALA A 128
GLY A  64
 None
 1.08A 2igtB-3h9pA:
undetectable		 2igtB-3h9pA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		5 PHE A  46
ALA A  61
PRO A  45
GLY A  42
GLY A  94
 None
 1.14A 2igtB-3htzA:
undetectable		 2igtB-3htzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00496
(SBP_bac_5) 		5 ALA A 421
ALA A 335
PRO A 326
GLY A 432
GLY A 422
 None
None
GOL  A 604 ( 4.6A)
GOL  A 604 (-3.2A)
None
 1.14A 2igtB-3lvuA:
undetectable		 2igtB-3lvuA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq9 BONE MARROW STROMAL
ANTIGEN 2 FUSED TO
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16716
(BST2) 		5 ALA A 269
ALA A  77
ALA A  52
GLY A  56
GLY A  54
 None
 1.09A 2igtB-3mq9A:
undetectable		 2igtB-3mq9A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		5 PHE B1552
ALA B1528
ALA B1031
GLY B1275
GLY B1277
 None
 1.11A 2igtB-3myrB:
undetectable		 2igtB-3myrB:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		5 ALA A  77
ALA A 370
ALA A  75
GLY A  82
GLY A  86
 None
 1.14A 2igtB-3ncyA:
undetectable		 2igtB-3ncyA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		5 ALA A 263
ALA A 488
PRO A 336
GLY A 483
TYR A 330
 None
 1.09A 2igtB-3nm1A:
2.4		 2igtB-3nm1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 233
SER A 335
ALA A 339
GLY A  50
TYR A 223
 None
 1.09A 2igtB-3oytA:
undetectable		 2igtB-3oytA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		5 ALA A 324
ALA A 305
PRO A 316
GLY A  67
GLY A 283
 None
ADP  A 354 (-2.7A)
None
None
None
 1.07A 2igtB-3uboA:
3.8		 2igtB-3uboA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uko ALCOHOL
DEHYDROGENASE
CLASS-3

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 238
ALA A 209
ALA A 214
GLY A 204
TYR A 232
 None
None
None
NAD  A 402 (-3.3A)
None
 1.07A 2igtB-3ukoA:
6.6		 2igtB-3ukoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 PHE A 523
PHE A 546
TYR A 548
SER A 570
PRO A 617
 None
SAM  A 802 (-4.5A)
SAM  A 802 (-4.7A)
None
SAM  A 802 ( 4.6A)
 0.70A 2igtB-3v8vA:
22.4		 2igtB-3v8vA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 PHE A 258
PHE A 138
ALA A 133
GLY A 166
GLY A 171
 None
 1.01A 2igtB-3wmeA:
undetectable		 2igtB-3wmeA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 5 PHE A 462
ALA A 494
ALA A 614
ALA A 451
GLY A 495
 None
 1.03A 2igtB-4a7kA:
undetectable		 2igtB-4a7kA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 SER A 123
ALA A 129
GLY A 169
GLY A 120
TYR A 219
 None
 1.11A 2igtB-4bhdA:
4.6		 2igtB-4bhdA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi3 SSP1

(Serratia
marcescens) 		PF14113
(Tae4) 		5 PHE A 122
ALA A  51
ALA A  89
GLY A 131
GLY A  84
 None
None
None
SO4  A1164 (-3.3A)
None
 1.01A 2igtB-4bi3A:
undetectable		 2igtB-4bi3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		5 TYR A 298
SER A 533
ALA A 492
ALA A 575
GLY A 563
 None
 1.07A 2igtB-4ccdA:
undetectable		 2igtB-4ccdA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dt5 ANTIFREEZE PROTEIN

(Rhagium
inquisitor) 		no annotation 5 ALA A  25
ALA A  44
ALA A  13
GLY A  48
GLY A   8
 None
 1.07A 2igtB-4dt5A:
undetectable		 2igtB-4dt5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		5 TYR A 300
ALA A 294
SER A 295
GLY A 290
TRP A 458
 None
 0.98A 2igtB-4f7aA:
undetectable		 2igtB-4f7aA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		5 PHE A 326
ALA A 188
ALA A 282
GLY A  56
GLY A 187
 None
 1.11A 2igtB-4iheA:
undetectable		 2igtB-4iheA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 ALA A 619
ALA A 584
GLY A 634
GLY A 630
TYR A 648
 None
 1.11A 2igtB-4j1yA:
undetectable		 2igtB-4j1yA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Brachyspira
murdochii) 		PF13407
(Peripla_BP_4) 		5 PHE A  39
ALA A 138
ALA A 321
GLY A 177
GLY A 181
 None
None
NO3  A 504 (-3.7A)
None
None
 1.09A 2igtB-4kqcA:
undetectable		 2igtB-4kqcA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E

(Butyrivibrio
proteoclasticus) 		PF04616
(Glyco_hydro_43) 		5 PHE A 292
ALA A 219
PRO A 259
GLY A 203
GLY A 201
 None
None
None
CA  A 401 ( 4.7A)
None
 1.09A 2igtB-4novA:
undetectable		 2igtB-4novA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		5 PHE A 167
ALA A 127
ALA A  32
GLY A 149
GLY A 123
 None
 1.08A 2igtB-4ohtA:
4.6		 2igtB-4ohtA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		5 ALA A 350
SER A 351
ALA A 407
ALA A 288
GLY A 327
 None
 1.12A 2igtB-4rqoA:
undetectable		 2igtB-4rqoA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1

(Homo sapiens) 		PF05609
(LAP1C) 		5 PHE A 492
PHE A 503
ALA A 507
GLY A 468
GLY A 472
 None
 1.09A 2igtB-4tvsA:
undetectable		 2igtB-4tvsA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A 394
ALA A 266
GLY A  92
GLY A  14
TRP A  68
 None
FAD  A 700 (-3.6A)
None
FAD  A 700 (-3.2A)
FAD  A 700 (-4.1A)
 1.08A 2igtB-4udrA:
2.8		 2igtB-4udrA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 ALA A 507
SER A 506
ALA A 487
GLY A 525
GLY A 522
 None
 1.14A 2igtB-4uozA:
2.2		 2igtB-4uozA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usr MONOOXYGENASE

(Pseudomonas
stutzeri) 		PF13738
(Pyr_redox_3) 		5 TYR A 321
SER A 133
ALA A 287
GLY A  41
TRP A  43
 None
FAD  A1355 ( 4.2A)
FAD  A1355 ( 4.6A)
FAD  A1355 (-3.4A)
FAD  A1355 (-4.0A)
 1.02A 2igtB-4usrA:
3.2		 2igtB-4usrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuk PUTATIVE HYDROLASE

(Acinetobacter
sp. NBRC 100985) 		PF00753
(Lactamase_B) 		5 TYR A  53
SER A 136
ALA A 140
GLY A  69
GLY A 132
 None
 1.14A 2igtB-4xukA:
undetectable		 2igtB-4xukA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		5 ALA A 111
ALA A 101
ALA A 115
PRO A 133
GLY A 162
 None
 1.11A 2igtB-4zm6A:
2.5		 2igtB-4zm6A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 ALA A  68
SER A  65
ALA A  70
GLY A  10
GLY A  12
 None
 0.93A 2igtB-5a3yA:
undetectable		 2igtB-5a3yA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqe MATRIX PROTEIN 1

(Influenza A
virus) 		PF00598
(Flu_M1) 		5 TYR A 132
ALA A 125
ALA A  96
GLY A  86
GLY A 122
 None
 1.05A 2igtB-5cqeA:
undetectable		 2igtB-5cqeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		5 ALA A  17
ALA A 184
GLY A 366
GLY A 353
TYR A 176
 FAD  A 601 (-3.6A)
None
FAD  A 601 ( 3.4A)
FAD  A 601 ( 3.8A)
None
 1.12A 2igtB-5hy5A:
2.7		 2igtB-5hy5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2

(Homo sapiens) 		PF05609
(LAP1C) 		5 PHE B 378
PHE B 389
ALA B 393
GLY B 354
GLY B 358
 None
 1.03A 2igtB-5j1sB:
undetectable		 2igtB-5j1sB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ALA B 915
SER B 866
ALA B 884
ALA B 926
GLY B 924
 None
 1.13A 2igtB-5jpnB:
undetectable		 2igtB-5jpnB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ALA B 915
SER B 866
ALA B 884
ALA B 926
GLY B 924
 None
 1.11A 2igtB-5jtwB:
undetectable		 2igtB-5jtwB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 PHE A 432
TYR A 386
ALA A 389
ALA A  86
GLY A  30
 None
 1.08A 2igtB-5kznA:
2.3		 2igtB-5kznA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 ALA A 463
ALA A 486
ALA A 446
GLY A 477
GLY A 464
 None
None
None
None
FAD  A1801 (-3.1A)
 1.15A 2igtB-5laeA:
4.1		 2igtB-5laeA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ALA A  97
ALA A  40
ALA A  95
GLY A 138
GLY A 134
 None
 0.87A 2igtB-5lhkA:
undetectable		 2igtB-5lhkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		5 ALA A  13
ALA A 180
GLY A 362
GLY A 349
TYR A 172
 None
 1.08A 2igtB-5lv9A:
3.7		 2igtB-5lv9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF

(Escherichia
coli;
Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1)
PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 PHE D 578
TYR D 568
ALA D 574
ALA F 201
GLY D 506
 None
 1.09A 2igtB-5mg3D:
undetectable		 2igtB-5mg3D:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A  95
ALA A 629
ALA A 341
GLY A 165
GLY A  91
 None
None
FAD  A 701 (-4.0A)
FAD  A 701 (-3.1A)
FAD  A 701 ( 4.9A)
 1.05A 2igtB-5nccA:
2.1		 2igtB-5nccA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td3 CATECHOL
1,2-DIOXYGENASE

(Burkholderia
vietnamiensis) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 239
ALA A 265
PRO A 119
GLY A  88
TYR A 121
 None
 1.16A 2igtB-5td3A:
undetectable		 2igtB-5td3A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umh CATECHOL
1,2-DIOXYGENASE

(Burkholderia
multivorans) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 228
ALA A 254
PRO A 108
GLY A  77
TYR A 110
 None
None
EDO  A 402 (-4.4A)
None
None
 1.15A 2igtB-5umhA:
undetectable		 2igtB-5umhA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE

(Streptomyces
ribosidificus) 		PF01041
(DegT_DnrJ_EryC1) 		5 PHE A  57
TYR A  53
SER A 259
ALA A 211
GLY A 209
 None
 1.11A 2igtB-5w70A:
2.6		 2igtB-5w70A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 5 PHE A 228
ALA A 204
SER A 203
ALA A  73
GLY A 209
 None
None
C6P  A 502 (-2.4A)
C6P  A 502 (-3.8A)
None
 1.12A 2igtB-5wt4A:
3.3		 2igtB-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E

(Staphylococcus
aureus) 		no annotation 5 PHE A 137
ALA A 170
ALA A 144
ALA A 223
GLY A 183
 None
 1.07A 2igtB-5xoeA:
undetectable		 2igtB-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		5 PHE A 337
ALA A 103
ALA A  51
GLY A  35
GLY A  43
 None
 0.96A 2igtB-5xoyA:
undetectable		 2igtB-5xoyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 ALA C 147
ALA C  80
ALA C 117
GLY C 120
GLY C 127
 None
 0.97A 2igtB-5xyiC:
undetectable		 2igtB-5xyiC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 5 ALA A 185
ALA A 150
GLY A  71
GLY A 182
TYR A 112
 None
 1.12A 2igtB-5y0mA:
undetectable		 2igtB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 5 PHE A 174
ALA A 116
ALA A 165
GLY A 108
GLY A 113
 None
 1.08A 2igtB-5y0mA:
undetectable		 2igtB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 5 PHE A 355
TYR A 356
ALA A 385
PRO A 460
TYR A 223
 None
 1.04A 2igtB-6bljA:
undetectable		 2igtB-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 ANTIBODY FAB HEAVY
CHAIN

(Mus musculus) 		no annotation 5 PHE A  70
ALA A  92
ALA A  90
GLY A  40
TYR A  60
 None
 1.03A 2igtB-6c08A:
undetectable		 2igtB-6c08A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbo C-6'
AMINOTRANSFERASE

(Micromonospora
echinospora) 		no annotation 5 PHE A 301
ALA A 311
ALA A 388
GLY A 344
GLY A 392
 None
 0.87A 2igtB-6cboA:
4.0		 2igtB-6cboA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 5 ALA A 341
ALA A 348
ALA A 337
PRO A 556
GLY A 494
 None
 0.91A 2igtB-6em0A:
3.6		 2igtB-6em0A:
undetectable