SIMILAR PATTERNS OF AMINO ACIDS FOR 2IGT_A_SAMA1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a80 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE A

(Corynebacterium
sp.) 		PF00248
(Aldo_ket_red) 		3 ASP A 252
ASP A 259
ASP A 249
 None
 0.73A 2igtA-1a80A:
undetectable		 2igtA-1a80A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		3 ASP A  42
ASP A  46
ASP A  68
 NAI  A 302 (-2.6A)
None
NAI  A 302 (-3.6A)
 0.69A 2igtA-1ahiA:
8.4		 2igtA-1ahiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dix EXTRACELLULAR
RIBONUCLEASE LE

(Solanum
lycopersicum) 		PF00445
(Ribonuclease_T2) 		3 ASP A   5
ASP A 179
ASP A   3
 None
 0.76A 2igtA-1dixA:
undetectable		 2igtA-1dixA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		3 ASP A 164
ASP A 168
ASP A 222
 None
 0.69A 2igtA-1gnxA:
undetectable		 2igtA-1gnxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASP A 204
ASP A 169
ASP A 409
 SWA  A1103 ( 3.0A)
None
None
 0.70A 2igtA-1hwwA:
undetectable		 2igtA-1hwwA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		3 ASP A 363
ASP A 341
ASP A 401
 None
 0.72A 2igtA-1jmzA:
undetectable		 2igtA-1jmzA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		3 ASP A 271
ASP A  46
ASP A  65
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.3A)
 0.70A 2igtA-1nw5A:
2.9		 2igtA-1nw5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9k NUCLEAR FACTOR OF
ACTIVATED T-CELLS,
CYTOPLASMIC 2
PROTO-ONCOGENE
PROTEIN C-FOS

(Homo sapiens;
Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer)
PF00170
(bZIP_1) 		3 ASP D 170
ASP D 163
ASP C 464
 None
 0.76A 2igtA-1s9kD:
undetectable		 2igtA-1s9kD:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		3 ASP A 195
ASP A 248
ASP A  56
 None
 0.59A 2igtA-1sdeA:
undetectable		 2igtA-1sdeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		3 ASP A 224
ASP A 262
ASP A 217
 None
 0.72A 2igtA-1up2A:
undetectable		 2igtA-1up2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3o ACYL CARRIER PROTEIN

(Thermus
thermophilus) 		PF00550
(PP-binding) 		3 ASP A  16
ASP A  51
ASP A  41
 None
 0.70A 2igtA-1x3oA:
undetectable		 2igtA-1x3oA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwm PHOSPHATE UPTAKE
REGULATOR

(Geobacillus
stearothermophilus) 		PF01895
(PhoU) 		3 ASP A 150
ASP A 156
ASP A 214
 None
 0.65A 2igtA-1xwmA:
undetectable		 2igtA-1xwmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo1 TRANSLATION
INITIATION FACTOR 2

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		3 ASP I 711
ASP I 706
ASP I 669
 A  F  76 ( 3.8A)
None
None
 0.70A 2igtA-1zo1I:
undetectable		 2igtA-1zo1I:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ASP A 273
ASP A 268
ASP A 239
 None
 0.65A 2igtA-2bvgA:
undetectable		 2igtA-2bvgA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		3 ASP A  62
ASP A 177
ASP A 194
 SAM  A 300 (-2.8A)
SAM  A 300 (-4.1A)
SAM  A 300 (-3.7A)
 0.27A 2igtA-2dpmA:
10.1		 2igtA-2dpmA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7d 5'(3')-DEOXYRIBONUCL
EOTIDASE, CYTOSOLIC
TYPE

(Homo sapiens) 		PF06941
(NT5C) 		3 ASP A 144
ASP A 147
ASP A  12
 ALF  A 400 ( 4.2A)
None
DUR  A 300 (-3.7A)
 0.55A 2igtA-2i7dA:
2.3		 2igtA-2i7dA:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		3 ASP A 161
ASP A 190
ASP A 211
 SAM  A1001 (-2.9A)
SAM  A1001 (-3.7A)
SAM  A1001 (-2.8A)
 0.04A 2igtA-2igtA:
55.4		 2igtA-2igtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is3 RIBONUCLEASE T

(Escherichia
coli) 		PF00929
(RNase_T) 		3 ASP A 125
ASP A 150
ASP A 186
 None
 0.72A 2igtA-2is3A:
undetectable		 2igtA-2is3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jar 5'(3')-DEOXYRIBONUCL
EOTIDASE

(Mus musculus) 		PF06941
(NT5C) 		3 ASP A 146
ASP A 149
ASP A  14
 UMP  A1200 ( 4.1A)
None
UMP  A1200 ( 3.6A)
 0.66A 2igtA-2jarA:
2.4		 2igtA-2jarA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2q SURFACTIN SYNTHETASE
THIOESTERASE SUBUNIT

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		3 ASP B 213
ASP B 190
ASP B 196
 None
 0.59A 2igtA-2k2qB:
undetectable		 2igtA-2k2qB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		3 ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.70A 2igtA-2nyuA:
12.4		 2igtA-2nyuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7f YRRB PROTEIN

(Bacillus
subtilis) 		PF07719
(TPR_2)
PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13414
(TPR_11) 		3 ASP A 190
ASP A 159
ASP A 195
 None
 0.72A 2igtA-2q7fA:
undetectable		 2igtA-2q7fA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		3 ASP A 218
ASP A 144
ASP A 138
 None
 0.67A 2igtA-2vp1A:
undetectable		 2igtA-2vp1A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		3 ASP A  99
ASP A 114
ASP A 130
 SAH  A1293 (-2.7A)
SAH  A1293 (-3.7A)
SAH  A1293 (-3.7A)
 0.74A 2igtA-2xyqA:
8.7		 2igtA-2xyqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		3 ASP B 207
ASP B 199
ASP B 246
 None
 0.75A 2igtA-2y9yB:
undetectable		 2igtA-2y9yB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 ASP A 108
ASP A 140
ASP A 158
 MTA  A 315 (-3.3A)
MTA  A 315 (-3.9A)
MTA  A 315 (-4.9A)
 0.71A 2igtA-3anxA:
8.3		 2igtA-3anxA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b49 LIN2189 PROTEIN

(Listeria
innocua) 		PF06445
(GyrI-like) 		3 ASP A  97
ASP A  42
ASP A  92
 None
 0.72A 2igtA-3b49A:
undetectable		 2igtA-3b49A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3p METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF01596
(Methyltransf_3) 		3 ASP A  87
ASP A 115
ASP A 132
 EDO  A 215 (-3.0A)
None
None
 0.50A 2igtA-3c3pA:
15.0		 2igtA-3c3pA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		3 ASP A 102
ASP A 130
ASP A 154
 SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
CA  A 238 ( 2.2A)
 0.45A 2igtA-3c3yA:
15.1		 2igtA-3c3yA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		3 ASP A 238
ASP A 232
ASP A 254
 None
 0.74A 2igtA-3dhuA:
undetectable		 2igtA-3dhuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di4 UNCHARACTERIZED
PROTEIN DUF1989

(Ruegeria
pomeroyi) 		PF09347
(DUF1989) 		3 ASP A 192
ASP A 144
ASP A 151
 None
 0.76A 2igtA-3di4A:
undetectable		 2igtA-3di4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efy CIF (CELL CYCLE
INHIBITING FACTOR)

(Escherichia
coli) 		PF16374
(CIF) 		3 ASP A 187
ASP A 160
ASP A 237
 None
 0.74A 2igtA-3efyA:
undetectable		 2igtA-3efyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f00 SYNAPTOTAGMIN-1

(Homo sapiens) 		PF00168
(C2) 		3 ASP A 238
ASP A 178
ASP A 172
 None
 0.76A 2igtA-3f00A:
undetectable		 2igtA-3f00A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi8 CHOLINE KINASE

(Plasmodium
falciparum) 		PF01633
(Choline_kinase) 		3 ASP A 195
ASP A 328
ASP A 189
 None
 0.76A 2igtA-3fi8A:
undetectable		 2igtA-3fi8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		3 ASP A  60
ASP A  64
ASP A  83
 None
 0.64A 2igtA-3gvcA:
6.7		 2igtA-3gvcA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		3 ASP A  55
ASP A  52
ASP A  31
 None
 0.75A 2igtA-3hh8A:
undetectable		 2igtA-3hh8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		3 ASP A 132
ASP A 139
ASP A 135
 None
 0.58A 2igtA-3hl1A:
undetectable		 2igtA-3hl1A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hps 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF08502
(LeuA_dimer) 		3 ASP A 395
ASP A 400
ASP A 388
 None
 0.74A 2igtA-3hpsA:
3.0		 2igtA-3hpsA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 3 ASP B 193
ASP B 225
ASP B 215
 None
None
MG  B 800 ( 4.0A)
 0.76A 2igtA-3kx2B:
4.8		 2igtA-3kx2B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		3 ASP A 242
ASP A 271
ASP A 292
 SAH  A 401 (-2.8A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.5A)
 0.58A 2igtA-3ldfA:
23.3		 2igtA-3ldfA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 ASP A 274
ASP A 254
ASP A 413
 None
 0.72A 2igtA-3lq1A:
3.3		 2igtA-3lq1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n90 THYLAKOID LUMENAL 15
KDA PROTEIN 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00805
(Pentapeptide) 		3 ASP A 188
ASP A 147
ASP A 191
 None
 0.45A 2igtA-3n90A:
undetectable		 2igtA-3n90A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		3 ASP A 817
ASP A 812
ASP A 885
 None
 0.73A 2igtA-3nafA:
6.0		 2igtA-3nafA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe8 ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		3 ASP A  51
ASP A  47
ASP A  13
 None
 0.68A 2igtA-3pe8A:
undetectable		 2igtA-3pe8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		3 ASP A 296
ASP A 331
ASP A 431
 None
 0.64A 2igtA-3qanA:
4.4		 2igtA-3qanA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r24 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		3 ASP A  99
ASP A 114
ASP A 130
 SAM  A 302 (-2.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
 0.72A 2igtA-3r24A:
8.5		 2igtA-3r24A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 EPITOPE SCAFFOLD
2BODX43

(Thermobifida
fusca;
Human
immunodeficiency
virus;
synthetic
construct) 		PF01341
(Glyco_hydro_6) 		3 ASP X 144
ASP X 206
ASP X  72
 GOL  X 283 (-3.3A)
None
None
 0.57A 2igtA-3ru8X:
undetectable		 2igtA-3ru8X:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 3 ASP A 234
ASP A 252
ASP A 275
 SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.53A 2igtA-3ssmA:
11.0		 2igtA-3ssmA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		3 ASP A  72
ASP A  33
ASP A  29
 None
 0.70A 2igtA-3t8lA:
undetectable		 2igtA-3t8lA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		3 ASP A 107
ASP A 166
ASP A 189
 SAH  A 258 (-2.7A)
SAH  A 258 (-3.4A)
SAH  A 258 ( 3.6A)
 0.64A 2igtA-3tosA:
10.8		 2igtA-3tosA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		3 ASP A 568
ASP A 597
ASP A 615
 SAM  A 802 (-2.9A)
SAM  A 802 (-3.5A)
None
 0.58A 2igtA-3v8vA:
22.5		 2igtA-3v8vA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		3 ASP A 243
ASP A 272
ASP A 293
 SAH  A 401 (-2.7A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.2A)
 0.52A 2igtA-3vseA:
25.0		 2igtA-3vseA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		3 ASP A 564
ASP A 597
ASP A 536
 None
SO4  A1970 (-3.3A)
None
 0.72A 2igtA-3zgbA:
undetectable		 2igtA-3zgbA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ate BETA-PORPHYRANASE A

(Zobellia
galactanivorans) 		no annotation 3 ASP A 265
ASP A  37
ASP A  73
 CA  A1275 (-3.4A)
None
None
 0.47A 2igtA-4ateA:
undetectable		 2igtA-4ateA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 ASP A 377
ASP A 144
ASP A 188
 CA  A 400 (-3.2A)
None
None
 0.53A 2igtA-4bpzA:
undetectable		 2igtA-4bpzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2
ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF00400
(WD40) 		3 ASP A  31
ASP C  35
ASP C 346
 None
 0.66A 2igtA-4bujA:
5.8		 2igtA-4bujA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 ASP A 231
ASP A 267
ASP A 255
 None
 0.75A 2igtA-4c2tA:
2.2		 2igtA-4c2tA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 ASP A 231
ASP A 267
ASP A 255
 None
 0.74A 2igtA-4c30A:
4.5		 2igtA-4c30A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqx PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		3 ASP A  58
ASP A  62
ASP A  81
 None
 0.68A 2igtA-4dqxA:
8.0		 2igtA-4dqxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		3 ASP A 218
ASP A 269
ASP A 259
 None
 0.62A 2igtA-4eysA:
undetectable		 2igtA-4eysA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8c CYCLE INHIBITING
FACTOR

(Yersinia
pseudotuberculosis) 		PF16374
(CIF) 		3 ASP A 195
ASP A 168
ASP A 245
 None
 0.73A 2igtA-4f8cA:
undetectable		 2igtA-4f8cA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fur UREASE SUBUNIT GAMMA
2

(Brucella
abortus) 		PF00547
(Urease_gamma) 		3 ASP A  71
ASP A  75
ASP A  67
 None
 0.76A 2igtA-4furA:
undetectable		 2igtA-4furA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 204
ASP A 237
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.63A 2igtA-4fzvA:
11.9		 2igtA-4fzvA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 114
ASP A  90
ASP A 312
 GOL  A 500 (-3.6A)
None
None
 0.69A 2igtA-4j6fA:
7.7		 2igtA-4j6fA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jva CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-BETA REGULATORY
SUBUNIT

(Rattus
norvegicus) 		PF00027
(cNMP_binding) 		3 ASP A 309
ASP A 214
ASP A 306
 None
 0.75A 2igtA-4jvaA:
undetectable		 2igtA-4jvaA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		3 ASP A 228
ASP A 222
ASP A  65
 None
 0.62A 2igtA-4kmaA:
undetectable		 2igtA-4kmaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		3 ASP A 355
ASP A 130
ASP A 391
 None
 0.68A 2igtA-4maaA:
2.7		 2igtA-4maaA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnd CTP
L-MYO-INOSITOL-1-PHO
SPHATE
CYTIDYLYLTRANSFERASE
/CDP-L-MYO-INOSITOL
MYO-INOSITOLPHOSPHOT
RANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf)
PF12804
(NTP_transf_3) 		3 ASP A 278
ASP A 171
ASP A 198
 None
 0.49A 2igtA-4mndA:
undetectable		 2igtA-4mndA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0n REPLICASE
POLYPROTEIN 1AB

(Equine
arteritis virus) 		PF01443
(Viral_helicase1) 		3 ASP A  80
ASP A 136
ASP A  73
 None
MG  A 509 (-2.8A)
None
 0.49A 2igtA-4n0nA:
2.7		 2igtA-4n0nA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npc SORBITOL
DEHYDROGENASE

(Brucella suis) 		PF13561
(adh_short_C2) 		3 ASP A  47
ASP A  51
ASP A  70
 None
 0.69A 2igtA-4npcA:
7.4		 2igtA-4npcA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omb PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		3 ASP A 123
ASP A 253
ASP A 304
 None
 0.70A 2igtA-4ombA:
undetectable		 2igtA-4ombA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdy CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF07949
(YbbR) 		3 ASP A  51
ASP A 113
ASP A  96
 None
 0.76A 2igtA-4qdyA:
undetectable		 2igtA-4qdyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsk KETOL-ACID
REDUCTOISOMERASE

(Alicyclobacillus
acidocaldarius) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 ASP A 123
ASP A  74
ASP A 162
 None
 0.74A 2igtA-4tskA:
4.1		 2igtA-4tskA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 ASP A 613
ASP A 722
ASP A 559
 None
 0.69A 2igtA-4xwhA:
undetectable		 2igtA-4xwhA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo7 SUGAR ABC
TRANSPORTER
(SUGAR-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF13407
(Peripla_BP_4) 		3 ASP A 108
ASP A  83
ASP A 114
 None
 0.71A 2igtA-4yo7A:
4.8		 2igtA-4yo7A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7e LMO1422 PROTEIN

(Listeria
monocytogenes) 		PF04069
(OpuAC) 		3 ASP A 421
ASP A 472
ASP A 416
 1PE  A 604 (-3.2A)
None
None
 0.72A 2igtA-4z7eA:
undetectable		 2igtA-4z7eA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgz 4-OXALMESACONATE
HYDRATASE

(Pseudomonas
putida) 		PF02585
(PIG-L) 		3 ASP A  86
ASP A  89
ASP A  65
 GOL  A 308 (-3.3A)
None
None
 0.65A 2igtA-5cgzA:
3.4		 2igtA-5cgzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA1
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
delbrueckii;
Lactobacillus
delbrueckii) 		PF00005
(ABC_tran)
PF02361
(CbiQ) 		3 ASP D 217
ASP A  94
ASP A 168
 None
None
ANP  A 301 ( 4.4A)
 0.53A 2igtA-5d3mD:
undetectable		 2igtA-5d3mD:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		3 ASP A 567
ASP A 600
ASP A 539
 None
 0.71A 2igtA-5fdnA:
undetectable		 2igtA-5fdnA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 ASP A  46
ASP A  17
ASP A  82
 None
 0.73A 2igtA-5giuA:
undetectable		 2igtA-5giuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 3 ASP B 318
ASP B 306
ASP B 314
 None
 0.67A 2igtA-5hdfB:
2.2		 2igtA-5hdfB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		3 ASP A 544
ASP A 596
ASP A 683
 None
 0.76A 2igtA-5iq6A:
undetectable		 2igtA-5iq6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1

(Escherichia
coli) 		PF00884
(Sulfatase) 		3 ASP A 384
ASP A 457
ASP A 233
 None
 0.67A 2igtA-5k4pA:
undetectable		 2igtA-5k4pA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		3 ASP A  49
ASP A  80
ASP A  42
 None
 0.60A 2igtA-5kvaA:
14.3		 2igtA-5kvaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5log PUTATIVE
O-METHYLTRANSFERASE

(Myxococcus
xanthus) 		PF01596
(Methyltransf_3) 		3 ASP A  91
ASP A 119
ASP A 142
 SAH  A1001 (-2.8A)
SAH  A1001 (-3.8A)
MG  A1002 (-2.5A)
 0.49A 2igtA-5logA:
15.5		 2igtA-5logA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 ASP A 196
ASP A 228
ASP A 218
 None
None
MG  A 802 ( 4.0A)
 0.75A 2igtA-5ltaA:
5.5		 2igtA-5ltaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		3 ASP B 118
ASP B  99
ASP B  94
 None
None
CU  B 702 (-2.1A)
 0.71A 2igtA-5lxzB:
undetectable		 2igtA-5lxzB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6p TYROCIDINE SYNTHASE
2

(Brevibacillus
parabrevis) 		no annotation 3 ASP A3247
ASP A3159
ASP A3206
 None
 0.70A 2igtA-5m6pA:
undetectable		 2igtA-5m6pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE

(metagenome) 		no annotation 3 ASP A  83
ASP A  89
ASP A  78
 None
PEG  A 402 (-3.8A)
None
 0.76A 2igtA-5nfqA:
2.1		 2igtA-5nfqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6u CATHEPSIN K

(Mus musculus) 		PF00112
(Peptidase_C1) 		3 ASP A 136
ASP A 158
ASP A 152
 None
 0.60A 2igtA-5t6uA:
undetectable		 2igtA-5t6uA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9x GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 3 ASP A 331
ASP A  73
ASP A 116
 NA  A 401 (-3.2A)
None
None
 0.37A 2igtA-5t9xA:
undetectable		 2igtA-5t9xA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 3 ASP A 189
ASP A 248
ASP A 196
 None
 0.75A 2igtA-5vhaA:
4.8		 2igtA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 ASP A 238
ASP A 270
ASP A 260
 None
None
MG  A 804 (-3.5A)
 0.74A 2igtA-5xdrA:
2.6		 2igtA-5xdrA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgd GLUCOSE/GALACTOSE-BI
NDING LIPOPROTEIN

(Treponema
pallidum) 		no annotation 3 ASP A 357
ASP A 354
ASP A 332
 None
EDO  A 403 (-2.4A)
None
 0.65A 2igtA-6bgdA:
undetectable		 2igtA-6bgdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME

(Trypanosoma
brucei) 		no annotation 3 ASP E 171
ASP E 173
ASP E 139
 None
 0.63A 2igtA-6bm7E:
undetectable		 2igtA-6bm7E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 3 ASP A 129
ASP A 160
ASP A 178
 TER  A 402 ( 4.4A)
None
TER  A 402 (-4.1A)
 0.75A 2igtA-6bq6A:
12.3		 2igtA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c33 5'-3' EXONUCLEASE

(Mycolicibacterium
smegmatis) 		no annotation 3 ASP A 126
ASP A   9
ASP A  62
 None
MN  A 401 ( 4.1A)
None
 0.70A 2igtA-6c33A:
undetectable		 2igtA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 ASP A 170
ASP A  82
ASP A 217
 None
 0.66A 2igtA-6eotA:
undetectable		 2igtA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 3 ASP B  41
ASP B  48
ASP B 384
 None
 0.71A 2igtA-6evjB:
undetectable		 2igtA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 3 ASP A 396
ASP A 428
ASP A 418
 None
None
MG  A1002 ( 4.2A)
 0.74A 2igtA-6fa5A:
3.8		 2igtA-6fa5A:
undetectable