SIMILAR PATTERNS OF AMINO ACIDS FOR 2I30_A_SALA1200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		4 LEU A  61
ILE A 109
ILE A  91
ALA A  87
 None
 0.79A 2i30A-1bgpA:
0.5		 2i30A-1bgpA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee1 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
subtilis) 		PF02540
(NAD_synthase) 		4 LEU A  79
ILE A 146
ILE A  75
ALA A  76
 ATP  A5000 (-4.0A)
None
None
None
 0.81A 2i30A-1ee1A:
0.0		 2i30A-1ee1A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE

(Lactobacillus
pentosus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  91
ILE A 159
ILE A 293
ALA A 261
 None
 0.73A 2i30A-1ez4A:
0.1		 2i30A-1ez4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fb5 ORNITHINE
TRANSCARBAMOYLASE

(Ovis aries) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 179
ILE A 261
ILE A 204
ALA A 208
 None
 0.89A 2i30A-1fb5A:
0.0		 2i30A-1fb5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5z OUTER SURFACE
PROTEIN C

(Borreliella
burgdorferi) 		PF01441
(Lipoprotein_6) 		4 LEU A 137
ILE A  69
ILE A 103
ALA A 102
 None
 0.62A 2i30A-1g5zA:
undetectable		 2i30A-1g5zA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggq OUTER SURFACE
PROTEIN C

(Borreliella
burgdorferi) 		PF01441
(Lipoprotein_6) 		4 LEU A 138
ILE A  69
ILE A 104
ALA A 103
 None
 0.65A 2i30A-1ggqA:
2.2		 2i30A-1ggqA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 4 LEU A 295
ILE A 287
ILE A 303
ALA A 275
 None
 0.79A 2i30A-1juhA:
undetectable		 2i30A-1juhA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 LEU A  57
ILE A 134
ILE A  97
ALA A  98
 None
 0.78A 2i30A-1kczA:
0.9		 2i30A-1kczA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ku9 HYPOTHETICAL PROTEIN
MJ223

(Methanocaldococcus
jannaschii) 		PF01022
(HTH_5) 		4 LEU A  65
ILE A  47
ILE A  34
ALA A  33
 None
 0.78A 2i30A-1ku9A:
0.0		 2i30A-1ku9A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  91
ILE A 159
ILE A 293
ALA A 261
 None
 0.78A 2i30A-1ldnA:
0.0		 2i30A-1ldnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN

(Schizosaccharomyces
pombe) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 LEU A 166
ILE A 215
ILE A 188
ALA A 187
 None
 0.76A 2i30A-1ni3A:
2.1		 2i30A-1ni3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 237
ILE A 155
ILE A 141
ALA A 140
 None
 0.72A 2i30A-1oypA:
undetectable		 2i30A-1oypA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		4 LEU A 505
ILE A 351
ILE A 493
ALA A 492
 None
 0.85A 2i30A-1rh1A:
2.0		 2i30A-1rh1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sei RIBOSOMAL PROTEIN S8

(Geobacillus
stearothermophilus) 		PF00410
(Ribosomal_S8) 		4 LEU A  10
ILE A 103
ILE A  38
ALA A  36
 None
 0.84A 2i30A-1seiA:
undetectable		 2i30A-1seiA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II

(Homo sapiens) 		PF00106
(adh_short) 		4 LEU A  30
ILE A 151
ILE A 240
ALA A 239
 None
 0.70A 2i30A-1so8A:
undetectable		 2i30A-1so8A:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 LEU A 219
ILE A 264
ILE A 290
ALA A 291
 None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
 0.31A 2i30A-1tf0A:
38.3		 2i30A-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
mansoni) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 158
ILE A  20
ILE A  74
ALA A  73
 None
 0.87A 2i30A-1u3iA:
1.6		 2i30A-1u3iA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpd TARTRONATE
SEMIALDEHYDE
REDUCTASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 LEU A  92
ILE A   8
ILE A  55
ALA A  56
 None
 0.89A 2i30A-1vpdA:
undetectable		 2i30A-1vpdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wox HEME OXYGENASE 2

(Synechocystis
sp. PCC 6803) 		PF01126
(Heme_oxygenase) 		4 LEU A  52
ILE A  68
ILE A 120
ALA A 121
 None
 0.83A 2i30A-1woxA:
undetectable		 2i30A-1woxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 LEU A 262
ILE A 468
ILE A  22
ALA A  23
 None
 0.80A 2i30A-1xrsA:
undetectable		 2i30A-1xrsA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0v PUTATIVE PROTEASE LA
HOMOLOG TYPE

(Archaeoglobus
fulgidus) 		PF05362
(Lon_C) 		4 LEU A 596
ILE A 481
ILE A 522
ALA A 521
 None
 0.87A 2i30A-1z0vA:
undetectable		 2i30A-1z0vA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE

(Bacillus
anthracis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  68
ILE A 119
ILE A 106
ALA A 107
 None
 0.79A 2i30A-2btuA:
undetectable		 2i30A-2btuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cai GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
haematobium) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 158
ILE A  20
ILE A  74
ALA A  73
 None
 0.87A 2i30A-2caiA:
undetectable		 2i30A-2caiA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esb DUAL SPECIFICITY
PROTEIN PHOSPHATASE
18

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A  27
ILE A  50
ILE A  86
ALA A  87
 None
 0.84A 2i30A-2esbA:
undetectable		 2i30A-2esbA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		4 LEU A 111
ILE A 100
ILE A 117
ALA A 116
 None
 0.72A 2i30A-2fk6A:
undetectable		 2i30A-2fk6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 170
ILE A  44
ILE A   6
ALA A   7
 None
 0.77A 2i30A-2hivA:
undetectable		 2i30A-2hivA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 LEU A 300
ILE A 334
ILE A 320
ALA A 321
 None
 0.88A 2i30A-2iu3A:
undetectable		 2i30A-2iu3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD

(Aquifex
aeolicus) 		PF00005
(ABC_tran) 		4 LEU A 130
ILE A 182
ILE A 151
ALA A 150
 None
EDO  A 235 ( 4.9A)
None
None
 0.85A 2i30A-2pclA:
undetectable		 2i30A-2pclA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
anthracis) 		PF02540
(NAD_synthase) 		4 LEU A  80
ILE A 147
ILE A  76
ALA A  77
 APC  A3001 (-4.1A)
None
None
None
 0.85A 2i30A-2pz8A:
undetectable		 2i30A-2pz8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 LEU A 133
ILE A 146
ILE A  94
ALA A 114
 None
 0.87A 2i30A-2v1uA:
undetectable		 2i30A-2v1uA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS

(Fasciola
hepatica) 		PF14497
(GST_C_3) 		4 LEU A 158
ILE A  20
ILE A  74
ALA A  73
 None
 0.80A 2i30A-2wduA:
3.5		 2i30A-2wduA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  68
ILE A 119
ILE A 106
ALA A 107
 None
 0.87A 2i30A-2z01A:
undetectable		 2i30A-2z01A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE

(Gluconobacter
frateurii) 		PF13561
(adh_short_C2) 		4 LEU A  51
ILE A  12
ILE A  23
ALA A  22
 None
 0.79A 2i30A-3ai2A:
undetectable		 2i30A-3ai2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5e MLL8374 PROTEIN

(Mesorhizobium
japonicum) 		no annotation 4 LEU A  48
ILE A 163
ILE A 207
ALA A 206
 None
 0.69A 2i30A-3b5eA:
undetectable		 2i30A-3b5eA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b81 TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY

(Clostridium
acetobutylicum) 		PF00440
(TetR_N) 		4 LEU A 157
ILE A  90
ILE A 134
ALA A 132
 None
EDO  A 205 (-4.5A)
None
None
 0.89A 2i30A-3b81A:
3.7		 2i30A-3b81A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		4 LEU A 153
ILE A 334
ILE A 136
ALA A 303
 None
 0.88A 2i30A-3bjeA:
undetectable		 2i30A-3bjeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT

(Methanosarcina
barkeri) 		PF02552
(CO_dh) 		4 LEU G 166
ILE G 112
ILE G  63
ALA G  61
 None
 0.84A 2i30A-3cf4G:
undetectable		 2i30A-3cf4G:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyq CHEMOTAXIS PROTEIN
MOTB

(Helicobacter
pylori) 		no annotation 4 LEU B 201
ILE B 229
ILE B 144
ALA B 145
 None
 0.77A 2i30A-3cyqB:
undetectable		 2i30A-3cyqB:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE

(Burkholderia
pseudomallei) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A  37
ILE A  45
ILE A  33
ALA A  34
 None
 0.84A 2i30A-3enkA:
undetectable		 2i30A-3enkA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Rickettsia
prowazekii) 		PF13561
(adh_short_C2) 		4 LEU A  46
ILE A  11
ILE A  22
ALA A  21
 None
 0.89A 2i30A-3f9iA:
undetectable		 2i30A-3f9iA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpn GEOBACILLUS
STEAROTHERMOPHILUS
UVRA INTERACTION
DOMAIN

(Geobacillus
stearothermophilus) 		no annotation 4 LEU A 221
ILE A 207
ILE A 213
ALA A 214
 None
 0.84A 2i30A-3fpnA:
2.1		 2i30A-3fpnA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxq LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 LEU A 111
ILE A 291
ILE A 102
ALA A 103
 None
 0.82A 2i30A-3fxqA:
undetectable		 2i30A-3fxqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7q VALINE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		4 LEU A 341
ILE A 398
ILE A 320
ALA A 319
 None
 0.83A 2i30A-3g7qA:
undetectable		 2i30A-3g7qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8r PROBABLE SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
E

(Chromobacterium
violaceum) 		PF03102
(NeuB)
PF08666
(SAF) 		4 LEU A 164
ILE A 117
ILE A 131
ALA A 132
 None
 0.85A 2i30A-3g8rA:
undetectable		 2i30A-3g8rA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 LEU A 124
ILE A 323
ILE A 257
ALA A 256
 None
 0.88A 2i30A-3h5qA:
undetectable		 2i30A-3h5qA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhh TRANSCRIPTIONAL
REGULATOR, PADR
FAMILY

(Enterococcus
faecalis) 		PF03551
(PadR) 		4 LEU A  53
ILE A  29
ILE A  18
ALA A  17
 None
 0.70A 2i30A-3hhhA:
undetectable		 2i30A-3hhhA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 LEU W 831
ILE W 819
ILE W 896
ALA W 895
 None
 0.82A 2i30A-3iylW:
undetectable		 2i30A-3iylW:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		4 LEU A 121
ILE A 195
ILE A  90
ALA A  86
 None
 0.82A 2i30A-3k1tA:
undetectable		 2i30A-3k1tA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 LEU A 279
ILE A 346
ILE A 310
ALA A 311
 None
 0.80A 2i30A-3k9dA:
undetectable		 2i30A-3k9dA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 LEU A  34
ILE A   7
ILE A 278
ALA A 320
 None
 0.79A 2i30A-3kd8A:
undetectable		 2i30A-3kd8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 206
ILE A 160
ILE A 176
ALA A 175
 None
 0.80A 2i30A-3kumA:
undetectable		 2i30A-3kumA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7w PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1704

(Streptococcus
mutans) 		PF03551
(PadR) 		4 LEU A  50
ILE A  28
ILE A  17
ALA A  16
 None
 0.78A 2i30A-3l7wA:
undetectable		 2i30A-3l7wA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7w PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1704

(Streptococcus
mutans) 		PF03551
(PadR) 		4 LEU A  56
ILE A  28
ILE A  17
ALA A  16
 None
 0.68A 2i30A-3l7wA:
undetectable		 2i30A-3l7wA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Burkholderia
mallei) 		PF00551
(Formyl_trans_N) 		4 LEU A 282
ILE A 240
ILE A 196
ALA A 195
 None
 0.76A 2i30A-3louA:
undetectable		 2i30A-3louA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mue PANTOTHENATE
SYNTHETASE

(Salmonella
enterica) 		PF02569
(Pantoate_ligase) 		4 LEU A 282
ILE A 245
ILE A 211
ALA A 212
 None
EOH  A 296 (-4.9A)
None
None
 0.79A 2i30A-3mueA:
undetectable		 2i30A-3mueA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6u LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF03466
(LysR_substrate) 		4 LEU A 111
ILE A 291
ILE A 102
ALA A 103
 None
 0.78A 2i30A-3n6uA:
undetectable		 2i30A-3n6uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		4 LEU A  57
ILE A  10
ILE A  42
ALA A  43
 None
 0.79A 2i30A-3o31A:
undetectable		 2i30A-3o31A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		4 LEU A 160
ILE A 173
ILE A  93
ALA A  89
 None
 0.82A 2i30A-3o82A:
undetectable		 2i30A-3o82A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		4 LEU A 117
ILE A   9
ILE A  82
ALA A 109
 None
 0.88A 2i30A-3ot5A:
undetectable		 2i30A-3ot5A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s06 MOTILITY PROTEIN B

(Helicobacter
pylori) 		PF00691
(OmpA) 		4 LEU A 201
ILE A 229
ILE A 144
ALA A 145
 None
 0.78A 2i30A-3s06A:
undetectable		 2i30A-3s06A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00619
(CARD)
PF00653
(BIR)
PF13920
(zf-C3HC4_3) 		4 LEU A 539
ILE A 510
ILE A 513
ALA A 521
 None
 0.78A 2i30A-3t6pA:
2.7		 2i30A-3t6pA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Francisella
tularensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 LEU A 138
ILE A 251
ILE A 259
ALA A 260
 None
 0.85A 2i30A-3tqvA:
undetectable		 2i30A-3tqvA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		4 LEU A 215
ILE A 181
ILE A 184
ALA A 189
 None
 0.83A 2i30A-3twkA:
undetectable		 2i30A-3twkA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A2434
ILE A2569
ILE A2501
ALA A2500
 None
 0.84A 2i30A-3vkgA:
undetectable		 2i30A-3vkgA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6j SCPB

(Geobacillus
stearothermophilus) 		PF04079
(SMC_ScpB) 		4 LEU B 137
ILE B 122
ILE B 110
ALA B 109
 None
 0.75A 2i30A-3w6jB:
undetectable		 2i30A-3w6jB:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wic GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		4 LEU A 158
ILE A 330
ILE A 151
ALA A 152
 None
 0.89A 2i30A-3wicA:
undetectable		 2i30A-3wicA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		4 LEU A 100
ILE A 106
ILE A  70
ALA A  71
 None
 0.72A 2i30A-4aurA:
undetectable		 2i30A-4aurA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		4 LEU A  63
ILE A  55
ILE A  92
ALA A  93
 None
 0.89A 2i30A-4b0tA:
undetectable		 2i30A-4b0tA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4z DEOXYHYPUSINE
HYDROXYLASE

(Homo sapiens) 		PF13646
(HEAT_2) 		4 LEU A 107
ILE A  71
ILE A  98
ALA A  97
 None
 0.81A 2i30A-4d4zA:
undetectable		 2i30A-4d4zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 LEU A1413
ILE A1362
ILE A1391
ALA A1390
 None
ACY  A1502 ( 4.7A)
None
None
 0.78A 2i30A-4ll6A:
undetectable		 2i30A-4ll6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 LEU A  63
ILE A  24
ILE A  35
ALA A  34
 None
 0.76A 2i30A-4nbrA:
undetectable		 2i30A-4nbrA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3

(Homo sapiens) 		PF10189
(Ints3) 		4 LEU A 433
ILE A 375
ILE A 350
ALA A 391
 None
 0.85A 2i30A-4owtA:
3.0		 2i30A-4owtA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN

(Vibrio cholerae) 		PF00501
(AMP-binding) 		4 LEU A  49
ILE A 253
ILE A  94
ALA A  90
 None
 0.86A 2i30A-4oxiA:
undetectable		 2i30A-4oxiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE

(Pyrococcus
horikoshii) 		PF01916
(DS) 		4 LEU A 294
ILE A 258
ILE A 268
ALA A 267
 None
 0.76A 2i30A-4p63A:
undetectable		 2i30A-4p63A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1n 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Clostridium
butyricum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 260
ILE A 192
ILE A 241
ALA A 240
 None
 0.70A 2i30A-4r1nA:
undetectable		 2i30A-4r1nA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF17170
(DUF5128) 		4 LEU A 110
ILE A  97
ILE A 122
ALA A 123
 None
 0.83A 2i30A-4raaA:
undetectable		 2i30A-4raaA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmx PHI92_GP150

(Enterobacteria
phage phi92) 		no annotation 4 LEU A 460
ILE A 404
ILE A 389
ALA A 388
 None
 0.85A 2i30A-4rmxA:
undetectable		 2i30A-4rmxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0p MELANOMA-ASSOCIATED
ANTIGEN 3

(Homo sapiens) 		PF01454
(MAGE) 		4 LEU A 256
ILE A 221
ILE A 208
ALA A 207
 None
 0.80A 2i30A-4v0pA:
undetectable		 2i30A-4v0pA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 LEU A1033
ILE A1058
ILE A1050
ALA A1049
 None
 0.84A 2i30A-4zwjA:
2.1		 2i30A-4zwjA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3v BILIVERDIN REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 4 LEU B 114
ILE B  77
ILE B  87
ALA B  86
 None
 0.89A 2i30A-5b3vB:
undetectable		 2i30A-5b3vB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6f BACTERIAL NON-HEME
FERRITIN

(Helicobacter
pylori) 		PF00210
(Ferritin) 		4 LEU A  43
ILE A 137
ILE A 161
ALA A 162
 None
 0.89A 2i30A-5c6fA:
undetectable		 2i30A-5c6fA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		4 LEU A 148
ILE A  71
ILE A  96
ALA A  95
 None
 0.82A 2i30A-5d9nA:
undetectable		 2i30A-5d9nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5de3 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		4 LEU A 106
ILE A  91
ILE A 138
ALA A 139
 None
 0.81A 2i30A-5de3A:
undetectable		 2i30A-5de3A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 LEU A 220
ILE A 135
ILE A 208
ALA A 207
 None
 0.86A 2i30A-5dmhA:
undetectable		 2i30A-5dmhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dok TELOMERASE
ASSOCIATED PROTEIN
P45

(Tetrahymena
thermophila) 		no annotation 4 LEU A 275
ILE A 236
ILE A 262
ALA A 263
 None
 0.85A 2i30A-5dokA:
undetectable		 2i30A-5dokA:
14.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 LEU A 218
ILE A 263
ILE A 289
ALA A 290
 None
None
PG4  A 602 ( 4.4A)
PG4  A 602 (-3.4A)
 0.38A 2i30A-5dqfA:
42.5		 2i30A-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 410
ILE A 548
ILE A 583
ALA A 584
 None
 0.82A 2i30A-5fjjA:
undetectable		 2i30A-5fjjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LEU A 221
ILE A 296
ILE A 351
ALA A 350
 None
 0.83A 2i30A-5h8yA:
undetectable		 2i30A-5h8yA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		4 LEU A 301
ILE A 367
ILE A 331
ALA A 332
 None
 0.88A 2i30A-5j78A:
undetectable		 2i30A-5j78A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 LEU S 417
ILE S 386
ILE S 454
ALA S 455
 None
 0.88A 2i30A-5k0yS:
undetectable		 2i30A-5k0yS:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU B 655
ILE B 714
ILE B 640
ALA B 641
 None
 0.70A 2i30A-5ldrB:
undetectable		 2i30A-5ldrB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  20
ILE A  84
ILE A 249
ALA A 246
 None
 0.84A 2i30A-5mdhA:
undetectable		 2i30A-5mdhA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE

(Bacillus
subtilis) 		no annotation 4 LEU A  33
ILE A 134
ILE A  17
ALA A  18
 None
 0.89A 2i30A-5np9A:
undetectable		 2i30A-5np9A:
9.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 LEU A 218
ILE A 263
ILE A 289
ALA A 290
 None
 0.45A 2i30A-5oriA:
41.3		 2i30A-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		4 LEU A 239
ILE A 120
ILE A 243
ALA A 242
 None
NAP  A 407 ( 4.6A)
NAP  A 407 (-3.6A)
None
 0.86A 2i30A-5u63A:
undetectable		 2i30A-5u63A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 LEU A 509
ILE A 402
ILE A 460
ALA A 461
 None
 0.87A 2i30A-5vylA:
undetectable		 2i30A-5vylA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdd BCL-2-RELATED
OVARIAN KILLER
PROTEIN

(Gallus gallus) 		no annotation 4 LEU A  34
ILE A 175
ILE A  70
ALA A  69
 None
 0.76A 2i30A-5wddA:
2.8		 2i30A-5wddA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US13

(Toxoplasma
gondii) 		PF00416
(Ribosomal_S13) 		4 LEU S  18
ILE S  46
ILE S  72
ALA S  71
 None
 0.85A 2i30A-5xxuS:
undetectable		 2i30A-5xxuS:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yww NUCLEOTIDE BINDING
PROTEIN PINC

(Sulfolobus
islandicus) 		no annotation 4 LEU A 231
ILE A 376
ILE A 253
ALA A 265
 None
 0.84A 2i30A-5ywwA:
undetectable		 2i30A-5ywwA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4h NUCLEOPORIN GLE1

(Chaetomium
thermophilum) 		no annotation 4 LEU A 259
ILE A 274
ILE A 354
ALA A 353
 None
None
None
MES  A 604 (-2.7A)
 0.77A 2i30A-6b4hA:
2.1		 2i30A-6b4hA:
9.81