SIMILAR PATTERNS OF AMINO ACIDS FOR 2I30_A_SALA1100

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ava BARLEY
ALPHA-AMYLASE/SUBTIL
ISIN INHIBITOR

(Hordeum vulgare) 		PF00197
(Kunitz_legume) 		4 HIS C 108
PHE C 163
GLY C 159
LYS C 158
 None
 0.95A 2i30A-1avaC:
undetectable		 2i30A-1avaC:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		4 HIS A  41
TYR A 233
ARG A  69
GLY A  70
 None
 1.43A 2i30A-1azwA:
0.0		 2i30A-1azwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1

(Escherichia
coli) 		PF05785
(CNF1) 		4 PHE A 729
TYR A 755
ARG A 981
GLY A 853
 None
 1.23A 2i30A-1hq0A:
0.0		 2i30A-1hq0A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		4 HIS A 167
ARG A 142
GLY A 146
LYS A 145
 None
 1.47A 2i30A-1o0sA:
0.0		 2i30A-1o0sA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		4 HIS 2  99
PHE 2 251
ARG 2 257
GLY 2  93
 None
 1.34A 2i30A-1rhi2:
undetectable		 2i30A-1rhi2:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		4 PHE A 230
ARG A 356
GLY A 359
LYS A 360
 None
None
FAD  A 634 ( 4.6A)
None
 1.04A 2i30A-1rq1A:
1.0		 2i30A-1rq1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1s 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Escherichia
coli) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 HIS A 208
TYR A 314
ARG A 190
GLY A 184
 SO4  A1001 (-3.8A)
None
None
SO4  A1001 (-3.2A)
 1.40A 2i30A-1t1sA:
0.0		 2i30A-1t1sA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 HIS A 132
PHE A 191
ARG A 186
GLY A 188
 None
 1.39A 2i30A-1uzgA:
undetectable		 2i30A-1uzgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		4 PHE A 182
TYR A  68
GLY A  46
LYS A  45
 None
 1.26A 2i30A-1wl8A:
0.0		 2i30A-1wl8A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		4 HIS A  44
TYR A 235
ARG A  72
GLY A  73
 None
 1.28A 2i30A-1x2bA:
0.0		 2i30A-1x2bA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 124
TYR A 353
ARG A 350
GLY A  63
 None
 1.42A 2i30A-1y9aA:
0.0		 2i30A-1y9aA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 HIS A 631
PHE A 634
TYR A 665
ARG A 624
 None
HEM  A 901 ( 4.7A)
PGR  A 804 (-4.5A)
PGR  A 805 (-4.2A)
 1.09A 2i30A-1yiqA:
2.2		 2i30A-1yiqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		4 HIS A 144
PHE A 161
ARG A 146
GLY A 147
 None
 1.40A 2i30A-1ypxA:
undetectable		 2i30A-1ypxA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aoq DNA MISMATCH REPAIR
PROTEIN MUTH

(Haemophilus
influenzae) 		PF02976
(MutH) 		4 HIS A  73
PHE A  71
GLY A  60
LYS A   9
 None
 1.14A 2i30A-2aoqA:
undetectable		 2i30A-2aoqA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d37 HYPOTHETICAL
NADH-DEPENDENT FMN
OXIDOREDUCTASE

(Sulfurisphaera
tokodaii) 		PF01613
(Flavin_Reduct) 		4 HIS A 123
TYR A  59
GLY A  54
LYS A  53
 NAD  A 300 (-3.8A)
None
None
NAD  A 300 ( 2.7A)
 1.27A 2i30A-2d37A:
undetectable		 2i30A-2d37A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 PHE A 153
TYR A 323
ARG A 135
GLY A 137
 None
 1.35A 2i30A-2elcA:
undetectable		 2i30A-2elcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgn PHOSPHOLIPASE C

(Bacillus cereus) 		PF00882
(Zn_dep_PLPC) 		4 TYR A 145
ARG A 223
GLY A 221
LYS A 222
 None
 0.97A 2i30A-2fgnA:
undetectable		 2i30A-2fgnA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 PHE X  91
ARG X  82
GLY X  26
LYS X  27
 None
 0.88A 2i30A-2jfeX:
undetectable		 2i30A-2jfeX:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8v THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 12

(Homo sapiens) 		PF13899
(Thioredoxin_7) 		4 PHE A  74
TYR A 126
GLY A 135
LYS A 137
 None
 1.47A 2i30A-2k8vA:
undetectable		 2i30A-2k8vA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lem APOLIPOPROTEIN A-I

(Mus musculus) 		PF01442
(Apolipoprotein) 		4 HIS A 165
ARG A  26
GLY A  25
LYS A  22
 None
 1.24A 2i30A-2lemA:
2.8		 2i30A-2lemA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mox SORBIN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00018
(SH3_1)
PF07653
(SH3_2) 		4 PHE A 842
TYR A 823
GLY A 840
LYS A 810
 None
 1.38A 2i30A-2moxA:
undetectable		 2i30A-2moxA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 PHE A 323
ARG A 298
GLY A 297
LYS A 296
 PHE  A 323 ( 1.3A)
ARG  A 298 ( 0.6A)
GLY  A 297 ( 0.0A)
LYS  A 296 ( 0.0A)
 1.14A 2i30A-2nvvA:
undetectable		 2i30A-2nvvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		4 HIS A 142
PHE A 254
ARG A 245
GLY A 269
 None
 1.45A 2i30A-2psfA:
undetectable		 2i30A-2psfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF11934
(DUF3452) 		4 PHE A 299
TYR A 321
GLY A 203
LYS A 202
 None
 1.50A 2i30A-2qdjA:
1.5		 2i30A-2qdjA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgz PUTATIVE PRIMOSOME
COMPONENT

(Streptococcus
pyogenes) 		PF01695
(IstB_IS21) 		4 PHE A 143
ARG A 290
GLY A 154
LYS A 153
 None
 1.42A 2i30A-2qgzA:
undetectable		 2i30A-2qgzA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		4 HIS A 341
PHE A 195
TYR A 128
LYS A 340
 None
 1.30A 2i30A-2qp2A:
undetectable		 2i30A-2qp2A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE

(Rhodospirillum
rubrum) 		PF03747
(ADP_ribosyl_GH) 		4 HIS A 176
TYR A 224
ARG A 187
GLY A 182
 None
 1.50A 2i30A-2wocA:
1.4		 2i30A-2wocA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 PHE A 251
TYR A 500
ARG A 524
GLY A 255
 None
 1.36A 2i30A-2yfnA:
undetectable		 2i30A-2yfnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		4 PHE D 300
TYR D 354
ARG D 381
LYS D 362
 None
 1.18A 2i30A-2ynmD:
undetectable		 2i30A-2ynmD:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 PHE A 419
TYR A 397
ARG A 411
GLY A 415
 None
 1.37A 2i30A-2yw2A:
undetectable		 2i30A-2yw2A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z37 CHITINASE

(Brassica juncea) 		PF00182
(Glyco_hydro_19) 		4 HIS A 211
PHE A 364
TYR A 231
GLY A 216
 None
 1.09A 2i30A-2z37A:
undetectable		 2i30A-2z37A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 HIS A 371
PHE A 385
ARG A 419
GLY A 436
 None
 1.34A 2i30A-2zuyA:
undetectable		 2i30A-2zuyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7j UNCHARACTERIZED
PROTEIN SCO6650

(Streptomyces
coelicolor) 		PF01242
(PTPS) 		4 HIS A 100
ARG A  98
GLY A 102
LYS A 101
 None
 1.17A 2i30A-3d7jA:
undetectable		 2i30A-3d7jA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 HIS A 144
PHE A 242
GLY A 246
LYS A 245
 None
 1.47A 2i30A-3ezyA:
undetectable		 2i30A-3ezyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnb ACYLAMINOACYL
PEPTIDASE SMU_737

(Streptococcus
mutans) 		PF12146
(Hydrolase_4) 		4 PHE A 110
ARG A 169
GLY A 196
LYS A 197
 None
 1.50A 2i30A-3fnbA:
2.3		 2i30A-3fnbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 219
TYR A 241
ARG A 264
GLY A 245
 None
 1.29A 2i30A-3gdcA:
undetectable		 2i30A-3gdcA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y MS30

(Homo sapiens) 		PF00829
(Ribosomal_L21p) 		4 HIS s 154
PHE s 176
GLY s 364
LYS s 365
 None
 1.33A 2i30A-3j7ys:
undetectable		 2i30A-3j7ys:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 HIS A 349
PHE A 360
ARG A 352
GLY A 358
 None
 1.37A 2i30A-3k28A:
undetectable		 2i30A-3k28A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9i BH0479 PROTEIN

(Bacillus
halodurans) 		PF12688
(TPR_5) 		4 HIS A 107
PHE A 104
GLY A  70
LYS A  71
 None
 1.07A 2i30A-3k9iA:
2.0		 2i30A-3k9iA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 4 PHE A 193
TYR A 299
ARG A 212
GLY A 214
 MLA  A1004 (-4.1A)
None
None
MLA  A1004 (-3.2A)
 1.32A 2i30A-3pf7A:
1.2		 2i30A-3pf7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		4 PHE A  32
TYR A  73
GLY A  16
LYS A  17
 None
 1.18A 2i30A-3qt3A:
undetectable		 2i30A-3qt3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi) 		PF00224
(PK)
PF02887
(PK_C) 		4 HIS A  58
PHE A  53
GLY A 201
LYS A 199
 None
 1.40A 2i30A-3qv9A:
undetectable		 2i30A-3qv9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Sphaerobacter
thermophilus) 		PF12697
(Abhydrolase_6) 		4 PHE A 114
TYR A 234
ARG A 219
GLY A 211
 None
 1.16A 2i30A-3r0vA:
undetectable		 2i30A-3r0vA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 PHE A 682
TYR A 643
GLY A 640
LYS A 639
 None
 1.13A 2i30A-3ve2A:
undetectable		 2i30A-3ve2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		4 HIS A 379
PHE A 376
ARG A 325
GLY A 354
 None
 1.24A 2i30A-3wh7A:
undetectable		 2i30A-3wh7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE

(Methanocaldococcus
jannaschii) 		PF05889
(SepSecS) 		4 PHE A  89
ARG A 215
GLY A 214
LYS A 235
 None
LLP  A 234 ( 3.9A)
None
LLP  A 234 ( 3.6A)
 1.44A 2i30A-3wksA:
undetectable		 2i30A-3wksA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akd MANNOSE-SPECIFIC
LECTIN KM+

(Artocarpus
integer) 		PF01419
(Jacalin) 		4 HIS A  57
PHE A  41
TYR A  24
LYS A 134
 None
 1.42A 2i30A-4akdA:
undetectable		 2i30A-4akdA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 HIS A 351
TYR A 396
GLY A 391
LYS A 392
 None
 1.22A 2i30A-4ci8A:
undetectable		 2i30A-4ci8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 PHE A 251
TYR A 508
ARG A 532
GLY A 255
 None
 1.32A 2i30A-4fnqA:
undetectable		 2i30A-4fnqA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gjh TNF
RECEPTOR-ASSOCIATED
FACTOR 5

(Mus musculus) 		no annotation 4 HIS A 476
TYR A 410
GLY A 402
LYS A 403
 None
 1.12A 2i30A-4gjhA:
undetectable		 2i30A-4gjhA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
NON-STRUCTURAL
PROTEIN V

(Mammalian
rubulavirus 5;
Sus scrofa) 		PF00271
(Helicase_C)
PF13008
(zf-Paramyx-P) 		4 HIS A 708
PHE A 709
ARG B 172
GLY A 718
 None
 1.23A 2i30A-4i1sA:
2.7		 2i30A-4i1sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iil MEMBRANE LIPOPROTEIN
TPN38(B)

(Treponema
pallidum) 		PF02608
(Bmp) 		4 PHE A 203
TYR A 231
ARG A 141
GLY A 229
 None
 1.48A 2i30A-4iilA:
undetectable		 2i30A-4iilA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 4 PHE A  71
ARG A  63
GLY A  64
LYS A  62
 None
 1.22A 2i30A-4jw1A:
undetectable		 2i30A-4jw1A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6q VOSA

(Aspergillus
nidulans) 		PF11754
(Velvet) 		4 PHE A 116
TYR A  65
ARG A  53
GLY A 114
 None
 1.46A 2i30A-4n6qA:
undetectable		 2i30A-4n6qA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf0 PROBABLE
C4-DICARBOXYLATE-BIN
DING PROTEIN

(Pseudomonas
aeruginosa) 		PF03480
(DctP) 		4 HIS A  35
PHE A  33
GLY A  46
LYS A  45
 None
 1.12A 2i30A-4nf0A:
undetectable		 2i30A-4nf0A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 PHE A 529
TYR A 503
ARG A 298
GLY A 500
 None
None
GOL  A 603 (-4.1A)
GOL  A 603 ( 4.3A)
 1.49A 2i30A-4o4xA:
undetectable		 2i30A-4o4xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 HIS A 934
TYR A 972
ARG A 929
GLY A 932
 None
 1.29A 2i30A-4pj6A:
undetectable		 2i30A-4pj6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 HIS A 438
PHE A 424
ARG A 441
GLY A 344
 None
 1.45A 2i30A-4qiwA:
2.9		 2i30A-4qiwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri1 UDP-4-AMINO-4,6-DIDE
OXY-N-ACETYL-BETA-L-
ALTROSAMINE
N-ACETYLTRANSFERASE

(Helicobacter
pylori) 		PF13420
(Acetyltransf_4) 		4 PHE A 115
TYR A 166
GLY A 171
LYS A 170
 None
 1.34A 2i30A-4ri1A:
undetectable		 2i30A-4ri1A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryk LMO0325 PROTEIN

(Listeria
monocytogenes) 		PF01381
(HTH_3) 		4 PHE A  61
TYR A  23
ARG A   9
GLY A   5
 None
 1.14A 2i30A-4rykA:
3.2		 2i30A-4rykA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udj UHGB_MP

(uncultured
organism) 		PF04041
(Glyco_hydro_130) 		4 PHE A 145
TYR A 182
ARG A 162
GLY A 192
 None
 1.42A 2i30A-4udjA:
undetectable		 2i30A-4udjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN

(Clostridioides
difficile) 		PF02661
(Fic) 		4 HIS A 156
PHE A 159
ARG A 200
GLY A 170
 None
None
ATP  A 302 (-3.5A)
ATP  A 302 (-3.2A)
 1.47A 2i30A-4x2dA:
undetectable		 2i30A-4x2dA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 HIS A 145
TYR A 113
ARG A 158
GLY A 157
 None
 1.50A 2i30A-4yweA:
undetectable		 2i30A-4yweA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a) 		4 HIS C 593
PHE C 559
ARG C 578
GLY C 576
 None
 1.05A 2i30A-5a6fC:
undetectable		 2i30A-5a6fC:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 HIS B 683
PHE B 725
GLY B 747
LYS B 748
 None
 1.44A 2i30A-5cxcB:
undetectable		 2i30A-5cxcB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9q NIH45-46 SINGLE
CHAIN FV

(Homo sapiens) 		PF07686
(V-set) 		4 HIS D 106
TYR D 234
GLY D  95
LYS D  96
 None
 1.45A 2i30A-5d9qD:
undetectable		 2i30A-5d9qD:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 HIS A 389
PHE A 107
GLY A 126
LYS A 127
 None
None
None
EDO  A1877 (-2.7A)
 1.48A 2i30A-5fjiA:
undetectable		 2i30A-5fjiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkx TBPB

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C) 		4 PHE A 605
TYR A 580
GLY A 577
LYS A 576
 None
 1.22A 2i30A-5kkxA:
undetectable		 2i30A-5kkxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00291
(PALP) 		4 HIS B 314
TYR B 323
ARG B 320
GLY B 319
 None
 1.48A 2i30A-5kzmB:
undetectable		 2i30A-5kzmB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 PHE A 618
TYR A 578
ARG A 932
GLY A  88
 None
 1.34A 2i30A-5ldnA:
undetectable		 2i30A-5ldnA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT

(Ovis aries) 		PF00420
(Oxidored_q2) 		4 TYR k 171
ARG k 126
GLY k  34
LYS k  35
 None
 1.49A 2i30A-5lnkk:
undetectable		 2i30A-5lnkk:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 PHE A 102
TYR A 453
ARG A 389
GLY A 385
 None
 1.14A 2i30A-5nbsA:
undetectable		 2i30A-5nbsA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 HIS A 233
PHE A 237
ARG A 451
GLY A 435
 None
None
PLM  A 702 (-4.1A)
None
 1.49A 2i30A-5nccA:
undetectable		 2i30A-5nccA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
wolfeii) 		PF01493
(GXGXG) 		4 HIS C 249
PHE C 222
GLY C 256
LYS C 255
 None
 1.36A 2i30A-5t5iC:
undetectable		 2i30A-5t5iC:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te6 HEAVY CHAIN OF N6

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 HIS H  32
ARG H   1
GLY H  26
LYS H   1
 None
 1.49A 2i30A-5te6H:
undetectable		 2i30A-5te6H:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 HIS A 593
PHE A 559
ARG A 578
GLY A 576
 None
 1.34A 2i30A-5u70A:
2.7		 2i30A-5u70A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 PHE A 936
TYR A 888
GLY A 942
LYS A 943
 None
 1.35A 2i30A-5ue8A:
2.6		 2i30A-5ue8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 PHE A 245
TYR A 356
GLY A 119
LYS A 118
 None
 1.08A 2i30A-5welA:
3.0		 2i30A-5welA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd2 NUDIX FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		4 TYR A 315
ARG A 296
GLY A 298
LYS A 297
 GOL  A 403 (-4.8A)
None
None
ATP  A 402 (-2.8A)
 1.23A 2i30A-5xd2A:
undetectable		 2i30A-5xd2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 4 PHE A 652
TYR A 435
ARG A 514
GLY A 465
 None
None
ANP  A1001 (-3.6A)
None
 1.32A 2i30A-5xipA:
undetectable		 2i30A-5xipA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica) 		no annotation 4 HIS A  41
TYR A 235
ARG A  69
GLY A  70
 None
 1.38A 2i30A-5yhpA:
undetectable		 2i30A-5yhpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S4
RIBOSOMAL PROTEIN S5

(Leishmania
donovani) 		no annotation 4 HIS F 164
TYR F 209
ARG D  56
GLY F 189
 None
A  1   2 ( 3.3A)
G  1   1 ( 4.5A)
None
 1.19A 2i30A-6az1F:
undetectable		 2i30A-6az1F:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 4 HIS A  78
PHE A 102
ARG A  16
GLY A  14
 None
 1.48A 2i30A-6cc2A:
undetectable		 2i30A-6cc2A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Mus musculus) 		no annotation 4 HIS A 182
PHE A 185
ARG A 159
GLY A 161
 None
 1.48A 2i30A-6cv9A:
undetectable		 2i30A-6cv9A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2v TERB OXIDOREDUCTASE

(Streptomyces) 		no annotation 4 HIS A  76
PHE A 111
TYR A  64
GLY A  99
 None
 1.32A 2i30A-6d2vA:
undetectable		 2i30A-6d2vA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dhi -

(-) 		no annotation 4 HIS A 165
TYR A 350
GLY A  56
LYS A  55
 SNN  A 164 ( 3.8A)
None
None
None
 1.45A 2i30A-6dhiA:
undetectable		 2i30A-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Sus scrofa) 		no annotation 4 PHE B 956
TYR C 186
ARG B1035
GLY B1034
 None
 1.47A 2i30A-6exvB:
undetectable		 2i30A-6exvB:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkx ACETYL XYLAN
ESTERASE

(metagenome) 		no annotation 4 HIS C  91
TYR C 139
ARG C 119
GLY C 120
 None
 1.15A 2i30A-6fkxC:
undetectable		 2i30A-6fkxC:
9.35