SIMILAR PATTERNS OF AMINO ACIDS FOR 2I2Z_A_SALA1100_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a75 | PARVALBUMIN (Merlangiusmerlangus) |
PF13499(EF-hand_7) | 4 | LEU A 105LEU A 63ILE A 58ILE A 50 | None | 0.75A | 2i2zA-1a75A:undetectable | 2i2zA-1a75A:11.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cbk | PROTEIN(7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE) (Haemophilusinfluenzae) |
PF01288(HPPK) | 5 | LEU A 94LEU A 23ILE A 26ILE A 6ALA A 7 | None | 1.15A | 2i2zA-1cbkA:undetectable | 2i2zA-1cbkA:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g5z | OUTER SURFACEPROTEIN C (Borreliellaburgdorferi) |
PF01441(Lipoprotein_6) | 4 | LEU A 137ILE A 69ILE A 103ALA A 102 | None | 0.70A | 2i2zA-1g5zA:undetectable | 2i2zA-1g5zA:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ggq | OUTER SURFACEPROTEIN C (Borreliellaburgdorferi) |
PF01441(Lipoprotein_6) | 4 | LEU A 138ILE A 69ILE A 104ALA A 103 | None | 0.71A | 2i2zA-1ggqA:undetectable | 2i2zA-1ggqA:14.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gk2 | HISTIDINEAMMONIA-LYASE (Pseudomonasputida) |
PF00221(Lyase_aromatic) | 4 | LEU A 293LEU A 501ILE A 219ALA A 254 | None | 0.68A | 2i2zA-1gk2A:undetectable | 2i2zA-1gk2A:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyj | HYPOTHETICAL PROTEINYDCE (Escherichiacoli) |
PF01361(Tautomerase) | 4 | LEU A 20ILE A 24ILE A 41ALA A 42 | None | 0.74A | 2i2zA-1gyjA:undetectable | 2i2zA-1gyjA:9.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5s | URONATE ISOMERASE (Thermotogamaritima) |
PF02614(UxaC) | 4 | LEU A 339ILE A 291ILE A 320ALA A 321 | None | 0.68A | 2i2zA-1j5sA:undetectable | 2i2zA-1j5sA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oyp | RIBONUCLEASE PH (Bacillussubtilis) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 4 | LEU A 237ILE A 155ILE A 141ALA A 140 | None | 0.59A | 2i2zA-1oypA:undetectable | 2i2zA-1oypA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1so8 | 3-HYDROXYACYL-COADEHYDROGENASE TYPEII (Homo sapiens) |
PF00106(adh_short) | 4 | LEU A 30ILE A 151ILE A 240ALA A 239 | None | 0.69A | 2i2zA-1so8A:0.6 | 2i2zA-1so8A:18.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tf0 | SERUM ALBUMIN (Homo sapiens) |
PF00273(Serum_albumin) | 5 | LEU A 219LEU A 260ILE A 264ILE A 290ALA A 291 | NoneNoneNoneDKA A1003 ( 4.5A)CIT A2001 ( 3.9A) | 0.39A | 2i2zA-1tf0A:38.1 | 2i2zA-1tf0A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbg | PYRUVATE,ORTHOPHOSPHATE DIKINASE (Zea mays) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 4 | LEU A 622ILE A 708ILE A 690ALA A 689 | None | 0.61A | 2i2zA-1vbgA:0.5 | 2i2zA-1vbgA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vct | HYPOTHETICAL PROTEINPH0236 (Pyrococcushorikoshii) |
PF01895(PhoU)PF02080(TrkA_C) | 4 | LEU A 142ILE A 200ILE A 192ALA A 193 | None | 0.75A | 2i2zA-1vctA:undetectable | 2i2zA-1vctA:15.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vgj | HYPOTHETICAL PROTEINPH0099 (Pyrococcushorikoshii) |
PF02834(LigT_PEase) | 4 | LEU A 46LEU A 61ILE A 107ALA A 6 | None | 0.76A | 2i2zA-1vgjA:undetectable | 2i2zA-1vgjA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w55 | ISPD/ISPFBIFUNCTIONAL ENZYME (Campylobacterjejuni) |
PF01128(IspD)PF02542(YgbB) | 5 | LEU A 286LEU A 300ILE A 303ILE A 336ALA A 326 | None | 0.88A | 2i2zA-1w55A:undetectable | 2i2zA-1w55A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xrs | D-LYSINE5,6-AMINOMUTASEALPHA SUBUNIT (Acetoanaerobiumsticklandii) |
PF09043(Lys-AminoMut_A) | 4 | LEU A 262ILE A 468ILE A 22ALA A 23 | None | 0.66A | 2i2zA-1xrsA:undetectable | 2i2zA-1xrsA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkr | SENTRIN-SPECIFICPROTEASE 8 (Homo sapiens) |
PF02902(Peptidase_C48) | 4 | LEU A 136ILE A 62ILE A 71ALA A 72 | None | 0.59A | 2i2zA-2bkrA:undetectable | 2i2zA-2bkrA:15.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2btu | PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE (Bacillusanthracis) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | LEU A 68ILE A 119ILE A 106ALA A 107 | None | 0.72A | 2i2zA-2btuA:undetectable | 2i2zA-2btuA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fk6 | RIBONUCLEASE Z (Bacillussubtilis) |
PF12706(Lactamase_B_2) | 4 | LEU A 111ILE A 100ILE A 117ALA A 116 | None | 0.67A | 2i2zA-2fk6A:undetectable | 2i2zA-2fk6A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g40 | CONSERVEDHYPOTHETICAL PROTEIN (Deinococcusradiodurans) |
PF02589(LUD_dom) | 4 | LEU A 117LEU A 67ILE A 209ALA A 72 | None | 0.60A | 2i2zA-2g40A:undetectable | 2i2zA-2g40A:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2grv | LPQW (Mycolicibacteriumsmegmatis) |
PF00496(SBP_bac_5) | 4 | LEU A 285LEU A 413ILE A 305ALA A 300 | None | 0.71A | 2i2zA-2grvA:undetectable | 2i2zA-2grvA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hiv | THERMOSTABLE DNALIGASE (Sulfolobussolfataricus) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 4 | LEU A 170ILE A 44ILE A 6ALA A 7 | None | 0.76A | 2i2zA-2hivA:undetectable | 2i2zA-2hivA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ik8 | GUANINENUCLEOTIDE-BINDINGPROTEIN G(I),ALPHA-1 SUBUNIT (Homo sapiens) |
PF00503(G-alpha) | 4 | LEU A 107LEU A 156ILE A 84ALA A 83 | None | 0.71A | 2i2zA-2ik8A:undetectable | 2i2zA-2ik8A:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po4 | VIRION RNAPOLYMERASE (Escherichiavirus N4) |
no annotation | 4 | LEU A 999ILE A1007ILE A1025ALA A1026 | None | 0.74A | 2i2zA-2po4A:1.7 | 2i2zA-2po4A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qg7 | ETHANOLAMINE KINASEPV091845 (Plasmodiumvivax) |
PF01633(Choline_kinase) | 4 | LEU A 297ILE A 302ILE A 202ALA A 203 | None | 0.77A | 2i2zA-2qg7A:undetectable | 2i2zA-2qg7A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6f | EXCINUCLEASE ABCSUBUNIT A (Geobacillusstearothermophilus) |
PF00005(ABC_tran) | 4 | LEU A 678LEU A 651ILE A 672ALA A 656 | None | 0.73A | 2i2zA-2r6fA:1.9 | 2i2zA-2r6fA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wdu | GLUTATHIONETRANSFERASE SIGMACLASS (Fasciolahepatica) |
PF14497(GST_C_3) | 4 | LEU A 158ILE A 20ILE A 74ALA A 73 | None | 0.73A | 2i2zA-2wduA:2.8 | 2i2zA-2wduA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y4l | MANNOSYLGLYCERATESYNTHASE (Rhodothermusmarinus) |
no annotation | 4 | LEU A 325LEU A 230ILE A 142ALA A 235 | None | 0.69A | 2i2zA-2y4lA:undetectable | 2i2zA-2y4lA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aka | PUTATIVE CALCIUMBINDING PROTEIN (Streptomycescoelicolor) |
PF13499(EF-hand_7)PF13833(EF-hand_8) | 4 | LEU A 89LEU A 60ILE A 99ALA A 65 | None | 0.73A | 2i2zA-3akaA:2.2 | 2i2zA-3akaA:12.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ay5 | CYCLIN-D1-BINDINGPROTEIN 1 (Homo sapiens) |
PF13324(GCIP) | 4 | LEU A 245ILE A 241ILE A 295ALA A 292 | None | 0.77A | 2i2zA-3ay5A:undetectable | 2i2zA-3ay5A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3brq | HTH-TYPETRANSCRIPTIONALREGULATOR ASCG (Escherichiacoli) |
PF13377(Peripla_BP_3) | 4 | LEU A 86ILE A 94ILE A 68ALA A 67 | None | 0.68A | 2i2zA-3brqA:undetectable | 2i2zA-3brqA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c5i | CHOLINE KINASE (Plasmodiumknowlesi) |
PF01633(Choline_kinase) | 4 | LEU A 219ILE A 224ILE A 135ALA A 136 | None | 0.76A | 2i2zA-3c5iA:undetectable | 2i2zA-3c5iA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddn | D-3-PHOSPHOGLYCERATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00389(2-Hacid_dh)PF01842(ACT)PF02826(2-Hacid_dh_C) | 4 | LEU A 523LEU A 475ILE A 471ALA A 513 | None | 0.73A | 2i2zA-3ddnA:undetectable | 2i2zA-3ddnA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epj | TRNAISOPENTENYLTRANSFERASE (Saccharomycescerevisiae) |
PF01715(IPPT) | 4 | LEU A 34LEU A 315ILE A 334ALA A 333 | None | 0.67A | 2i2zA-3epjA:undetectable | 2i2zA-3epjA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g77 | CYTOSINE DEAMINASE (Escherichiacoli) |
PF07969(Amidohydro_3) | 5 | LEU A 13LEU A 376ILE A 22ILE A 29ALA A 369 | None | 1.33A | 2i2zA-3g77A:undetectable | 2i2zA-3g77A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7q | VALINE-PYRUVATEAMINOTRANSFERASE (Salmonellaenterica) |
PF00155(Aminotran_1_2) | 4 | LEU A 341ILE A 398ILE A 320ALA A 319 | None | 0.66A | 2i2zA-3g7qA:undetectable | 2i2zA-3g7qA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8r | PROBABLE SPORE COATPOLYSACCHARIDEBIOSYNTHESIS PROTEINE (Chromobacteriumviolaceum) |
PF03102(NeuB)PF08666(SAF) | 4 | LEU A 164ILE A 117ILE A 131ALA A 132 | None | 0.78A | 2i2zA-3g8rA:undetectable | 2i2zA-3g8rA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gio | PUTATIVEUNCHARACTERIZEDPROTEIN (Helicobacterpylori) |
PF16753(Tipalpha) | 4 | LEU A 152LEU A 90ILE A 86ILE A 176 | None | 0.69A | 2i2zA-3gioA:undetectable | 2i2zA-3gioA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hhh | TRANSCRIPTIONALREGULATOR, PADRFAMILY (Enterococcusfaecalis) |
PF03551(PadR) | 4 | LEU A 53ILE A 29ILE A 18ALA A 17 | None | 0.57A | 2i2zA-3hhhA:undetectable | 2i2zA-3hhhA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3w | PHOSPHOGLUCOSAMINEMUTASE (Francisellatularensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | LEU A 264ILE A 263ILE A 348ALA A 347 | None | 0.76A | 2i2zA-3i3wA:undetectable | 2i2zA-3i3wA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ico | 6-PHOSPHOGLUCONOLACTONASE (Mycobacteriumtuberculosis) |
PF01182(Glucosamine_iso) | 4 | LEU A 67LEU A 22ILE A 26ILE A 60 | None | 0.71A | 2i2zA-3icoA:undetectable | 2i2zA-3icoA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j81 | US19 (Kluyveromyceslactis) |
PF00203(Ribosomal_S19) | 4 | LEU P 60LEU P 116ILE P 85ILE P 107 | None | 0.75A | 2i2zA-3j81P:undetectable | 2i2zA-3j81P:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kum | DIPEPTIDE EPIMERASE (Enterococcusfaecalis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | LEU A 206ILE A 160ILE A 176ALA A 175 | None | 0.68A | 2i2zA-3kumA:undetectable | 2i2zA-3kumA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7w | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.1704 (Streptococcusmutans) |
PF03551(PadR) | 4 | LEU A 56ILE A 28ILE A 17ALA A 16 | None | 0.56A | 2i2zA-3l7wA:undetectable | 2i2zA-3l7wA:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lou | FORMYLTETRAHYDROFOLATE DEFORMYLASE (Burkholderiamallei) |
PF00551(Formyl_trans_N) | 4 | LEU A 282ILE A 240ILE A 196ALA A 195 | None | 0.62A | 2i2zA-3louA:undetectable | 2i2zA-3louA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ltl | BREFELDINA-INHIBITED GUANINENUCLEOTIDE-EXCHANGEPROTEIN 1 (Homo sapiens) |
PF01369(Sec7) | 4 | LEU A 743ILE A 717ILE A 733ALA A 734 | None | 0.77A | 2i2zA-3ltlA:2.9 | 2i2zA-3ltlA:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1c | ENVELOPEGLYCOPROTEIN H (Humanalphaherpesvirus2) |
PF02489(Herpes_glycop_H)PF17488(Herpes_glycoH_C) | 4 | LEU A 781LEU A 688ILE A 713ALA A 778 | None | 0.74A | 2i2zA-3m1cA:2.5 | 2i2zA-3m1cA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3num | SERINE PROTEASEHTRA1 (Homo sapiens) |
PF13365(Trypsin_2) | 4 | LEU A 364ILE A 360ILE A 251ALA A 252 | None | 0.72A | 2i2zA-3numA:undetectable | 2i2zA-3numA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4v | MTA/SAH NUCLEOSIDASE (Escherichiacoli) |
PF01048(PNP_UDP_1) | 4 | LEU A 63ILE A 6ILE A 178ALA A 179 | None | 0.72A | 2i2zA-3o4vA:undetectable | 2i2zA-3o4vA:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qc0 | SUGAR ISOMERASE (Sinorhizobiummeliloti) |
PF01261(AP_endonuc_2) | 4 | LEU A 6ILE A 8ILE A 263ALA A 264 | None | 0.76A | 2i2zA-3qc0A:undetectable | 2i2zA-3qc0A:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ram | HMRA PROTEIN (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | LEU A 123ILE A 65ILE A 57ALA A 58 | None | 0.75A | 2i2zA-3ramA:undetectable | 2i2zA-3ramA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rrv | ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteriumavium) |
PF00378(ECH_1) | 4 | LEU A 118LEU A 34ILE A 8ALA A 39 | None | 0.67A | 2i2zA-3rrvA:undetectable | 2i2zA-3rrvA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uyk | NDP-RHAMNOSYLTRANSFERASE (Saccharopolysporaspinosa) |
PF06722(DUF1205) | 4 | LEU A 267LEU A 237ILE A 222ALA A 242 | None | 0.74A | 2i2zA-3uykA:undetectable | 2i2zA-3uykA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v77 | PUTATIVEFUMARYLACETOACETATEISOMERASE/HYDROLASE (Oleispiraantarctica) |
PF01557(FAA_hydrolase) | 4 | LEU A 216ILE A 95ILE A 146ALA A 145 | None | 0.74A | 2i2zA-3v77A:undetectable | 2i2zA-3v77A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w6j | SCPB (Geobacillusstearothermophilus) |
PF04079(SMC_ScpB) | 4 | LEU B 137ILE B 122ILE B 110ALA B 109 | None | 0.77A | 2i2zA-3w6jB:undetectable | 2i2zA-3w6jB:16.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9h | ACRIFLAVINERESISTANCE PROTEIN B (Escherichiacoli) |
PF00873(ACR_tran) | 4 | LEU A 289LEU A 310ILE A 306ALA A 165 | None | 0.66A | 2i2zA-3w9hA:undetectable | 2i2zA-3w9hA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9h | ACRIFLAVINERESISTANCE PROTEIN B (Escherichiacoli) |
PF00873(ACR_tran) | 4 | LEU A 449ILE A 445ILE A 943ALA A 942 | None | 0.77A | 2i2zA-3w9hA:undetectable | 2i2zA-3w9hA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wpw | POMB (Vibrioalginolyticus) |
PF00691(OmpA) | 4 | LEU A 160ILE A 188ILE A 214ALA A 215 | None | 0.70A | 2i2zA-3wpwA:undetectable | 2i2zA-3wpwA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x1l | CMR4 (Archaeoglobusfulgidus) |
PF03787(RAMPs) | 4 | LEU C 54LEU C 13ILE C 330ILE C 45 | None | 0.76A | 2i2zA-3x1lC:undetectable | 2i2zA-3x1lC:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zkb | DNA GYRASE SUBUNIT B (Mycobacteriumtuberculosis) |
PF00204(DNA_gyraseB)PF02518(HATPase_c) | 4 | LEU A 354LEU A 392ILE A 289ALA A 290 | None | 0.78A | 2i2zA-3zkbA:undetectable | 2i2zA-3zkbA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4as5 | INOSITOLMONOPHOSPHATASE 1 (Mus musculus) |
PF00459(Inositol_P) | 4 | LEU A 258ILE A 262ILE A 251ALA A 252 | None | 0.74A | 2i2zA-4as5A:2.1 | 2i2zA-4as5A:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aur | LEOA (Escherichiacoli) |
PF00350(Dynamin_N) | 4 | LEU A 100ILE A 106ILE A 70ALA A 71 | None | 0.77A | 2i2zA-4aurA:2.8 | 2i2zA-4aurA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cmf | AMINOTRANSFERASE ([Nectria]haematococca) |
PF01063(Aminotran_4) | 4 | LEU A 284LEU A 210ILE A 260ALA A 163 | None | 0.67A | 2i2zA-4cmfA:undetectable | 2i2zA-4cmfA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d4g | APNAA1 (Planktothrixagardhii) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | LEU A 46LEU A 125ILE A 132ALA A 39 | None | 0.78A | 2i2zA-4d4gA:undetectable | 2i2zA-4d4gA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d4z | DEOXYHYPUSINEHYDROXYLASE (Homo sapiens) |
PF13646(HEAT_2) | 4 | LEU A 107ILE A 71ILE A 98ALA A 97 | None | 0.70A | 2i2zA-4d4zA:2.0 | 2i2zA-4d4zA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvl | TRKA DOMAIN PROTEIN (Geobactersulfurreducens) |
PF02080(TrkA_C)PF02254(TrkA_N) | 4 | LEU A 496LEU A 510ILE A 518ILE A 505 | None | 0.70A | 2i2zA-4gvlA:undetectable | 2i2zA-4gvlA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwt | THREONINE--TRNALIGASE, CYTOPLASMIC (Homo sapiens) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 4 | LEU A 365ILE A 385ILE A 634ALA A 635 | None | 0.58A | 2i2zA-4hwtA:undetectable | 2i2zA-4hwtA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jg5 | PUTATIVE CELLADHESION PROTEIN (Parabacteroidesdistasonis) |
PF06321(P_gingi_FimA) | 4 | LEU A 356LEU A 191ILE A 194ILE A 210 | None | 0.75A | 2i2zA-4jg5A:undetectable | 2i2zA-4jg5A:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mt1 | DRUG EFFLUX PROTEIN (Neisseriagonorrhoeae) |
PF00873(ACR_tran) | 4 | LEU A 391LEU A 561ILE A 667ALA A 461 | None | 0.77A | 2i2zA-4mt1A:undetectable | 2i2zA-4mt1A:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oah | MITOCHONDRIALDYNAMIC PROTEINMID51 (Mus musculus) |
PF03281(Mab-21) | 4 | LEU A 168LEU A 298ILE A 287ALA A 161 | None | 0.70A | 2i2zA-4oahA:undetectable | 2i2zA-4oahA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oya | ADENYLATE CYCLASETYPE 10 (Homo sapiens) |
PF00211(Guanylate_cyc) | 4 | LEU A 325ILE A 321ILE A 369ALA A 366 | GOL A 502 (-4.3A)NoneNoneNone | 0.73A | 2i2zA-4oyaA:undetectable | 2i2zA-4oyaA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p72 | PHENYLALANINE--TRNALIGASE BETA SUBUNIT (Pseudomonasaeruginosa) |
PF01588(tRNA_bind)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 4 | LEU A 735LEU A 782ILE A 778ALA A 726 | None | 0.72A | 2i2zA-4p72A:undetectable | 2i2zA-4p72A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpp | PROTEIN ARGININEN-METHYLTRANSFERASE6 (Homo sapiens) |
PF13649(Methyltransf_25) | 4 | LEU A 353LEU A 191ILE A 290ILE A 341 | 36S A1001 ( 4.5A)NoneNoneNone | 0.57A | 2i2zA-4qppA:undetectable | 2i2zA-4qppA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r10 | PROTEIN HUMPBACK-2 (Caenorhabditiselegans) |
PF00514(Arm) | 4 | LEU A 232LEU A 165ILE A 169ALA A 203 | None | 0.50A | 2i2zA-4r10A:undetectable | 2i2zA-4r10A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rmx | PHI92_GP150 (Enterobacteriaphage phi92) |
no annotation | 4 | LEU A 460ILE A 404ILE A 389ALA A 388 | None | 0.74A | 2i2zA-4rmxA:undetectable | 2i2zA-4rmxA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v0p | MELANOMA-ASSOCIATEDANTIGEN 3 (Homo sapiens) |
PF01454(MAGE) | 5 | LEU A 256LEU A 225ILE A 221ILE A 208ALA A 207 | None | 0.93A | 2i2zA-4v0pA:undetectable | 2i2zA-4v0pA:16.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4woy | MITOCHONDRIALDYNAMICS PROTEINMID49 (Mus musculus) |
PF03281(Mab-21) | 4 | LEU A 288ILE A 279ILE A 156ALA A 157 | None | 0.67A | 2i2zA-4woyA:2.6 | 2i2zA-4woyA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az4 | FLAGELLAR HOOKSUBUNIT PROTEIN (Campylobacterjejuni) |
PF07196(Flagellin_IN)PF07559(FlaE) | 4 | LEU A 296ILE A 346ILE A 317ALA A 318 | None | 0.77A | 2i2zA-5az4A:undetectable | 2i2zA-5az4A:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d9n | B-1,4-ENDOGLUCANASE (Prevotellabryantii) |
PF00150(Cellulase) | 4 | LEU A 148ILE A 71ILE A 96ALA A 95 | None | 0.77A | 2i2zA-5d9nA:undetectable | 2i2zA-5d9nA:18.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dqf | SERUM ALBUMIN (Equus caballus) |
PF00273(Serum_albumin) | 5 | LEU A 218LEU A 259ILE A 263ILE A 289ALA A 290 | NonePG4 A 602 ( 4.5A)NonePG4 A 602 ( 4.4A)PG4 A 602 (-3.4A) | 0.35A | 2i2zA-5dqfA:42.1 | 2i2zA-5dqfA:76.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f3y | UNCONVENTIONALMYOSIN-VIIB (Mus musculus) |
PF00784(MyTH4) | 4 | LEU A1436LEU A1408ILE A1410ALA A1466 | None | 0.76A | 2i2zA-5f3yA:undetectable | 2i2zA-5f3yA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjj | BETA-GLUCOSIDASE (Aspergillusoryzae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | LEU A 410LEU A 501ILE A 548ILE A 583ALA A 584 | None | 0.95A | 2i2zA-5fjjA:undetectable | 2i2zA-5fjjA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5u | BETA-HEXOSAMINIDASE (Pseudomonasaeruginosa) |
PF00933(Glyco_hydro_3) | 4 | LEU A 59LEU A 14ILE A 53ALA A 52 | None | 0.70A | 2i2zA-5g5uA:undetectable | 2i2zA-5g5uA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8y | SULFITE REDUCTASE[FERREDOXIN],CHLOROPLASTIC (Zea mays) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 4 | LEU A 221ILE A 296ILE A 351ALA A 350 | None | 0.65A | 2i2zA-5h8yA:undetectable | 2i2zA-5h8yA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdt | SISTER CHROMATIDCOHESION PROTEINPDS5 HOMOLOG B (Homo sapiens) |
no annotation | 4 | LEU A 262LEU A 196ILE A 229ALA A 218 | None | 0.71A | 2i2zA-5hdtA:3.9 | 2i2zA-5hdtA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijb | TOLL-LIKE RECEPTOR4, VARIABLELYMPHOCYTE RECEPTORB CHIMERA (Eptatretusburgeri;Mus musculus) |
PF00560(LRR_1)PF11921(DUF3439)PF13855(LRR_8) | 4 | LEU A 106LEU A 68ILE A 92ILE A 113 | None | 0.75A | 2i2zA-5ijbA:undetectable | 2i2zA-5ijbA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j07 | SUPEROXIDE DISMUTASE[CU-ZN],SUPEROXIDEDISMUTASE[CU-ZN],SUPEROXIDEDISMUTASE[CU-ZN],SUPEROXIDEDISMUTASE [CU-ZN] (Homo sapiens) |
PF00080(Sod_Cu) | 4 | LEU A 65ILE A 72ILE A 97ALA A 98 | None | 0.69A | 2i2zA-5j07A:undetectable | 2i2zA-5j07A:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jdx | PUTATIVE PEPTIDYLCARRIER PROTEIN (Serratia sp.) |
no annotation | 4 | LEU A 28LEU A 6ILE A 10ALA A 11 | None | 0.76A | 2i2zA-5jdxA:undetectable | 2i2zA-5jdxA:9.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kd0 | AROMATICPRENYLTRANSFERASE (Aspergillusterreus) |
PF11991(Trp_DMAT) | 4 | LEU A 42LEU A 105ILE A 92ALA A 35 | None | 0.74A | 2i2zA-5kd0A:undetectable | 2i2zA-5kd0A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldr | BETA-D-GALACTOSIDASE (Paracoccus sp.32d) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 4 | LEU B 655ILE B 714ILE B 640ALA B 641 | None | 0.67A | 2i2zA-5ldrB:undetectable | 2i2zA-5ldrB:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m97 | MICROTUBULEINTEGRITY PROTEINMAL3 (Schizosaccharomycespombe) |
no annotation | 4 | LEU B 45ILE B 42ILE B 67ALA B 66 | None | 0.78A | 2i2zA-5m97B:undetectable | 2i2zA-5m97B:8.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msw | THIOESTER REDUCTASEDOMAIN-CONTAININGPROTEIN (Segniliparusrugosus) |
PF00501(AMP-binding)PF00550(PP-binding) | 4 | LEU A 248LEU A 103ILE A 142ALA A 143 | None | 0.57A | 2i2zA-5mswA:2.2 | 2i2zA-5mswA:19.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ori | ALBUMIN (Capra hircus) |
no annotation | 5 | LEU A 218LEU A 259ILE A 263ILE A 289ALA A 290 | None | 0.38A | 2i2zA-5oriA:40.7 | 2i2zA-5oriA:74.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t0z | LIPOPROTEIN,PUTATIVE (Geobactermetallireducens) |
no annotation | 4 | LEU A 39LEU A 167ILE A 171ALA A 61 | None | 0.63A | 2i2zA-5t0zA:undetectable | 2i2zA-5t0zA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdd | BCL-2-RELATEDOVARIAN KILLERPROTEIN (Gallus gallus) |
no annotation | 4 | LEU A 34ILE A 175ILE A 70ALA A 69 | None | 0.74A | 2i2zA-5wddA:1.5 | 2i2zA-5wddA:9.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5whm | ICLR FAMILYTRANSCRIPTIONALREGULATOR (Brucellaabortus) |
PF01614(IclR)PF09339(HTH_IclR) | 4 | LEU A 28LEU A 79ILE A 65ALA A 66 | None | 0.61A | 2i2zA-5whmA:undetectable | 2i2zA-5whmA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wug | BETA-GLUCOSIDASE (Paenibacillusbarengoltzii) |
no annotation | 4 | LEU A 819LEU A 776ILE A 743ALA A 812 | None | 0.78A | 2i2zA-5wugA:undetectable | 2i2zA-5wugA:7.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwb | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Colwelliapsychrerythraea) |
PF00275(EPSP_synthase) | 4 | LEU A 281LEU A 394ILE A 256ALA A 323 | None | 0.76A | 2i2zA-5xwbA:undetectable | 2i2zA-5xwbA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yxe | SERUM ALBUMIN (Felis catus) |
no annotation | 4 | LEU A 219LEU A 260ILE A 264ILE A 290 | None | 0.43A | 2i2zA-5yxeA:37.8 | 2i2zA-5yxeA:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4h | NUCLEOPORIN GLE1 (Chaetomiumthermophilum) |
no annotation | 4 | LEU A 259ILE A 274ILE A 354ALA A 353 | NoneNoneNoneMES A 604 (-2.7A) | 0.78A | 2i2zA-6b4hA:undetectable | 2i2zA-6b4hA:9.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cwp | RIBONUCLEOTIDEREDUCTASE (Flavobacteriumjohnsoniae) |
no annotation | 4 | LEU A 240ILE A 243ILE A 170ALA A 169 | None | 0.69A | 2i2zA-6cwpA:undetectable | 2i2zA-6cwpA:10.40 |