SIMILAR PATTERNS OF AMINO ACIDS FOR 2I2Z_A_SALA1100

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a75 PARVALBUMIN

(Merlangius
merlangus)
PF13499
(EF-hand_7)
4 LEU A 105
LEU A  63
ILE A  58
ILE A  50
None
0.75A 2i2zA-1a75A:
undetectable
2i2zA-1a75A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)


(Haemophilus
influenzae)
PF01288
(HPPK)
5 LEU A  94
LEU A  23
ILE A  26
ILE A   6
ALA A   7
None
1.15A 2i2zA-1cbkA:
undetectable
2i2zA-1cbkA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5z OUTER SURFACE
PROTEIN C


(Borreliella
burgdorferi)
PF01441
(Lipoprotein_6)
4 LEU A 137
ILE A  69
ILE A 103
ALA A 102
None
0.70A 2i2zA-1g5zA:
undetectable
2i2zA-1g5zA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggq OUTER SURFACE
PROTEIN C


(Borreliella
burgdorferi)
PF01441
(Lipoprotein_6)
4 LEU A 138
ILE A  69
ILE A 104
ALA A 103
None
0.71A 2i2zA-1ggqA:
undetectable
2i2zA-1ggqA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE


(Pseudomonas
putida)
PF00221
(Lyase_aromatic)
4 LEU A 293
LEU A 501
ILE A 219
ALA A 254
None
0.68A 2i2zA-1gk2A:
undetectable
2i2zA-1gk2A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyj HYPOTHETICAL PROTEIN
YDCE


(Escherichia
coli)
PF01361
(Tautomerase)
4 LEU A  20
ILE A  24
ILE A  41
ALA A  42
None
0.74A 2i2zA-1gyjA:
undetectable
2i2zA-1gyjA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima)
PF02614
(UxaC)
4 LEU A 339
ILE A 291
ILE A 320
ALA A 321
None
0.68A 2i2zA-1j5sA:
undetectable
2i2zA-1j5sA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
4 LEU A 237
ILE A 155
ILE A 141
ALA A 140
None
0.59A 2i2zA-1oypA:
undetectable
2i2zA-1oypA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II


(Homo sapiens)
PF00106
(adh_short)
4 LEU A  30
ILE A 151
ILE A 240
ALA A 239
None
0.69A 2i2zA-1so8A:
0.6
2i2zA-1so8A:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
5 LEU A 219
LEU A 260
ILE A 264
ILE A 290
ALA A 291
None
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
0.39A 2i2zA-1tf0A:
38.1
2i2zA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE


(Zea mays)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
4 LEU A 622
ILE A 708
ILE A 690
ALA A 689
None
0.61A 2i2zA-1vbgA:
0.5
2i2zA-1vbgA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vct HYPOTHETICAL PROTEIN
PH0236


(Pyrococcus
horikoshii)
PF01895
(PhoU)
PF02080
(TrkA_C)
4 LEU A 142
ILE A 200
ILE A 192
ALA A 193
None
0.75A 2i2zA-1vctA:
undetectable
2i2zA-1vctA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgj HYPOTHETICAL PROTEIN
PH0099


(Pyrococcus
horikoshii)
PF02834
(LigT_PEase)
4 LEU A  46
LEU A  61
ILE A 107
ALA A   6
None
0.76A 2i2zA-1vgjA:
undetectable
2i2zA-1vgjA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME


(Campylobacter
jejuni)
PF01128
(IspD)
PF02542
(YgbB)
5 LEU A 286
LEU A 300
ILE A 303
ILE A 336
ALA A 326
None
0.88A 2i2zA-1w55A:
undetectable
2i2zA-1w55A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT


(Acetoanaerobium
sticklandii)
PF09043
(Lys-AminoMut_A)
4 LEU A 262
ILE A 468
ILE A  22
ALA A  23
None
0.66A 2i2zA-1xrsA:
undetectable
2i2zA-1xrsA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkr SENTRIN-SPECIFIC
PROTEASE 8


(Homo sapiens)
PF02902
(Peptidase_C48)
4 LEU A 136
ILE A  62
ILE A  71
ALA A  72
None
0.59A 2i2zA-2bkrA:
undetectable
2i2zA-2bkrA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE


(Bacillus
anthracis)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 LEU A  68
ILE A 119
ILE A 106
ALA A 107
None
0.72A 2i2zA-2btuA:
undetectable
2i2zA-2btuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis)
PF12706
(Lactamase_B_2)
4 LEU A 111
ILE A 100
ILE A 117
ALA A 116
None
0.67A 2i2zA-2fk6A:
undetectable
2i2zA-2fk6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g40 CONSERVED
HYPOTHETICAL PROTEIN


(Deinococcus
radiodurans)
PF02589
(LUD_dom)
4 LEU A 117
LEU A  67
ILE A 209
ALA A  72
None
0.60A 2i2zA-2g40A:
undetectable
2i2zA-2g40A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis)
PF00496
(SBP_bac_5)
4 LEU A 285
LEU A 413
ILE A 305
ALA A 300
None
0.71A 2i2zA-2grvA:
undetectable
2i2zA-2grvA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE


(Sulfolobus
solfataricus)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
4 LEU A 170
ILE A  44
ILE A   6
ALA A   7
None
0.76A 2i2zA-2hivA:
undetectable
2i2zA-2hivA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT


(Homo sapiens)
PF00503
(G-alpha)
4 LEU A 107
LEU A 156
ILE A  84
ALA A  83
None
0.71A 2i2zA-2ik8A:
undetectable
2i2zA-2ik8A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE


(Escherichia
virus N4)
no annotation 4 LEU A 999
ILE A1007
ILE A1025
ALA A1026
None
0.74A 2i2zA-2po4A:
1.7
2i2zA-2po4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg7 ETHANOLAMINE KINASE
PV091845


(Plasmodium
vivax)
PF01633
(Choline_kinase)
4 LEU A 297
ILE A 302
ILE A 202
ALA A 203
None
0.77A 2i2zA-2qg7A:
undetectable
2i2zA-2qg7A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A


(Geobacillus
stearothermophilus)
PF00005
(ABC_tran)
4 LEU A 678
LEU A 651
ILE A 672
ALA A 656
None
0.73A 2i2zA-2r6fA:
1.9
2i2zA-2r6fA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS


(Fasciola
hepatica)
PF14497
(GST_C_3)
4 LEU A 158
ILE A  20
ILE A  74
ALA A  73
None
0.73A 2i2zA-2wduA:
2.8
2i2zA-2wduA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE


(Rhodothermus
marinus)
no annotation 4 LEU A 325
LEU A 230
ILE A 142
ALA A 235
None
0.69A 2i2zA-2y4lA:
undetectable
2i2zA-2y4lA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aka PUTATIVE CALCIUM
BINDING PROTEIN


(Streptomyces
coelicolor)
PF13499
(EF-hand_7)
PF13833
(EF-hand_8)
4 LEU A  89
LEU A  60
ILE A  99
ALA A  65
None
0.73A 2i2zA-3akaA:
2.2
2i2zA-3akaA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay5 CYCLIN-D1-BINDING
PROTEIN 1


(Homo sapiens)
PF13324
(GCIP)
4 LEU A 245
ILE A 241
ILE A 295
ALA A 292
None
0.77A 2i2zA-3ay5A:
undetectable
2i2zA-3ay5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG


(Escherichia
coli)
PF13377
(Peripla_BP_3)
4 LEU A  86
ILE A  94
ILE A  68
ALA A  67
None
0.68A 2i2zA-3brqA:
undetectable
2i2zA-3brqA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5i CHOLINE KINASE

(Plasmodium
knowlesi)
PF01633
(Choline_kinase)
4 LEU A 219
ILE A 224
ILE A 135
ALA A 136
None
0.76A 2i2zA-3c5iA:
undetectable
2i2zA-3c5iA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C)
4 LEU A 523
LEU A 475
ILE A 471
ALA A 513
None
0.73A 2i2zA-3ddnA:
undetectable
2i2zA-3ddnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE


(Saccharomyces
cerevisiae)
PF01715
(IPPT)
4 LEU A  34
LEU A 315
ILE A 334
ALA A 333
None
0.67A 2i2zA-3epjA:
undetectable
2i2zA-3epjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli)
PF07969
(Amidohydro_3)
5 LEU A  13
LEU A 376
ILE A  22
ILE A  29
ALA A 369
None
1.33A 2i2zA-3g77A:
undetectable
2i2zA-3g77A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7q VALINE-PYRUVATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00155
(Aminotran_1_2)
4 LEU A 341
ILE A 398
ILE A 320
ALA A 319
None
0.66A 2i2zA-3g7qA:
undetectable
2i2zA-3g7qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8r PROBABLE SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
E


(Chromobacterium
violaceum)
PF03102
(NeuB)
PF08666
(SAF)
4 LEU A 164
ILE A 117
ILE A 131
ALA A 132
None
0.78A 2i2zA-3g8rA:
undetectable
2i2zA-3g8rA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gio PUTATIVE
UNCHARACTERIZED
PROTEIN


(Helicobacter
pylori)
PF16753
(Tipalpha)
4 LEU A 152
LEU A  90
ILE A  86
ILE A 176
None
0.69A 2i2zA-3gioA:
undetectable
2i2zA-3gioA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhh TRANSCRIPTIONAL
REGULATOR, PADR
FAMILY


(Enterococcus
faecalis)
PF03551
(PadR)
4 LEU A  53
ILE A  29
ILE A  18
ALA A  17
None
0.57A 2i2zA-3hhhA:
undetectable
2i2zA-3hhhA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE


(Francisella
tularensis)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 LEU A 264
ILE A 263
ILE A 348
ALA A 347
None
0.76A 2i2zA-3i3wA:
undetectable
2i2zA-3i3wA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ico 6-PHOSPHOGLUCONOLACT
ONASE


(Mycobacterium
tuberculosis)
PF01182
(Glucosamine_iso)
4 LEU A  67
LEU A  22
ILE A  26
ILE A  60
None
0.71A 2i2zA-3icoA:
undetectable
2i2zA-3icoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j81 US19

(Kluyveromyces
lactis)
PF00203
(Ribosomal_S19)
4 LEU P  60
LEU P 116
ILE P  85
ILE P 107
None
0.75A 2i2zA-3j81P:
undetectable
2i2zA-3j81P:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 206
ILE A 160
ILE A 176
ALA A 175
None
0.68A 2i2zA-3kumA:
undetectable
2i2zA-3kumA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7w PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1704


(Streptococcus
mutans)
PF03551
(PadR)
4 LEU A  56
ILE A  28
ILE A  17
ALA A  16
None
0.56A 2i2zA-3l7wA:
undetectable
2i2zA-3l7wA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE


(Burkholderia
mallei)
PF00551
(Formyl_trans_N)
4 LEU A 282
ILE A 240
ILE A 196
ALA A 195
None
0.62A 2i2zA-3louA:
undetectable
2i2zA-3louA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1


(Homo sapiens)
PF01369
(Sec7)
4 LEU A 743
ILE A 717
ILE A 733
ALA A 734
None
0.77A 2i2zA-3ltlA:
2.9
2i2zA-3ltlA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H


(Human
alphaherpesvirus
2)
PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
4 LEU A 781
LEU A 688
ILE A 713
ALA A 778
None
0.74A 2i2zA-3m1cA:
2.5
2i2zA-3m1cA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3num SERINE PROTEASE
HTRA1


(Homo sapiens)
PF13365
(Trypsin_2)
4 LEU A 364
ILE A 360
ILE A 251
ALA A 252
None
0.72A 2i2zA-3numA:
undetectable
2i2zA-3numA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli)
PF01048
(PNP_UDP_1)
4 LEU A  63
ILE A   6
ILE A 178
ALA A 179
None
0.72A 2i2zA-3o4vA:
undetectable
2i2zA-3o4vA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc0 SUGAR ISOMERASE

(Sinorhizobium
meliloti)
PF01261
(AP_endonuc_2)
4 LEU A   6
ILE A   8
ILE A 263
ALA A 264
None
0.76A 2i2zA-3qc0A:
undetectable
2i2zA-3qc0A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 LEU A 123
ILE A  65
ILE A  57
ALA A  58
None
0.75A 2i2zA-3ramA:
undetectable
2i2zA-3ramA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacterium
avium)
PF00378
(ECH_1)
4 LEU A 118
LEU A  34
ILE A   8
ALA A  39
None
0.67A 2i2zA-3rrvA:
undetectable
2i2zA-3rrvA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE


(Saccharopolyspora
spinosa)
PF06722
(DUF1205)
4 LEU A 267
LEU A 237
ILE A 222
ALA A 242
None
0.74A 2i2zA-3uykA:
undetectable
2i2zA-3uykA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE


(Oleispira
antarctica)
PF01557
(FAA_hydrolase)
4 LEU A 216
ILE A  95
ILE A 146
ALA A 145
None
0.74A 2i2zA-3v77A:
undetectable
2i2zA-3v77A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6j SCPB

(Geobacillus
stearothermophilus)
PF04079
(SMC_ScpB)
4 LEU B 137
ILE B 122
ILE B 110
ALA B 109
None
0.77A 2i2zA-3w6jB:
undetectable
2i2zA-3w6jB:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B


(Escherichia
coli)
PF00873
(ACR_tran)
4 LEU A 289
LEU A 310
ILE A 306
ALA A 165
None
0.66A 2i2zA-3w9hA:
undetectable
2i2zA-3w9hA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B


(Escherichia
coli)
PF00873
(ACR_tran)
4 LEU A 449
ILE A 445
ILE A 943
ALA A 942
None
0.77A 2i2zA-3w9hA:
undetectable
2i2zA-3w9hA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpw POMB

(Vibrio
alginolyticus)
PF00691
(OmpA)
4 LEU A 160
ILE A 188
ILE A 214
ALA A 215
None
0.70A 2i2zA-3wpwA:
undetectable
2i2zA-3wpwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR4

(Archaeoglobus
fulgidus)
PF03787
(RAMPs)
4 LEU C  54
LEU C  13
ILE C 330
ILE C  45
None
0.76A 2i2zA-3x1lC:
undetectable
2i2zA-3x1lC:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
4 LEU A 354
LEU A 392
ILE A 289
ALA A 290
None
0.78A 2i2zA-3zkbA:
undetectable
2i2zA-3zkbA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1


(Mus musculus)
PF00459
(Inositol_P)
4 LEU A 258
ILE A 262
ILE A 251
ALA A 252
None
0.74A 2i2zA-4as5A:
2.1
2i2zA-4as5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli)
PF00350
(Dynamin_N)
4 LEU A 100
ILE A 106
ILE A  70
ALA A  71
None
0.77A 2i2zA-4aurA:
2.8
2i2zA-4aurA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmf AMINOTRANSFERASE

([Nectria]
haematococca)
PF01063
(Aminotran_4)
4 LEU A 284
LEU A 210
ILE A 260
ALA A 163
None
0.67A 2i2zA-4cmfA:
undetectable
2i2zA-4cmfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 LEU A  46
LEU A 125
ILE A 132
ALA A  39
None
0.78A 2i2zA-4d4gA:
undetectable
2i2zA-4d4gA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4z DEOXYHYPUSINE
HYDROXYLASE


(Homo sapiens)
PF13646
(HEAT_2)
4 LEU A 107
ILE A  71
ILE A  98
ALA A  97
None
0.70A 2i2zA-4d4zA:
2.0
2i2zA-4d4zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
4 LEU A 496
LEU A 510
ILE A 518
ILE A 505
None
0.70A 2i2zA-4gvlA:
undetectable
2i2zA-4gvlA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC


(Homo sapiens)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
4 LEU A 365
ILE A 385
ILE A 634
ALA A 635
None
0.58A 2i2zA-4hwtA:
undetectable
2i2zA-4hwtA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg5 PUTATIVE CELL
ADHESION PROTEIN


(Parabacteroides
distasonis)
PF06321
(P_gingi_FimA)
4 LEU A 356
LEU A 191
ILE A 194
ILE A 210
None
0.75A 2i2zA-4jg5A:
undetectable
2i2zA-4jg5A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae)
PF00873
(ACR_tran)
4 LEU A 391
LEU A 561
ILE A 667
ALA A 461
None
0.77A 2i2zA-4mt1A:
undetectable
2i2zA-4mt1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51


(Mus musculus)
PF03281
(Mab-21)
4 LEU A 168
LEU A 298
ILE A 287
ALA A 161
None
0.70A 2i2zA-4oahA:
undetectable
2i2zA-4oahA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10


(Homo sapiens)
PF00211
(Guanylate_cyc)
4 LEU A 325
ILE A 321
ILE A 369
ALA A 366
GOL  A 502 (-4.3A)
None
None
None
0.73A 2i2zA-4oyaA:
undetectable
2i2zA-4oyaA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT


(Pseudomonas
aeruginosa)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
4 LEU A 735
LEU A 782
ILE A 778
ALA A 726
None
0.72A 2i2zA-4p72A:
undetectable
2i2zA-4p72A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6


(Homo sapiens)
PF13649
(Methyltransf_25)
4 LEU A 353
LEU A 191
ILE A 290
ILE A 341
36S  A1001 ( 4.5A)
None
None
None
0.57A 2i2zA-4qppA:
undetectable
2i2zA-4qppA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans)
PF00514
(Arm)
4 LEU A 232
LEU A 165
ILE A 169
ALA A 203
None
0.50A 2i2zA-4r10A:
undetectable
2i2zA-4r10A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmx PHI92_GP150

(Enterobacteria
phage phi92)
no annotation 4 LEU A 460
ILE A 404
ILE A 389
ALA A 388
None
0.74A 2i2zA-4rmxA:
undetectable
2i2zA-4rmxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0p MELANOMA-ASSOCIATED
ANTIGEN 3


(Homo sapiens)
PF01454
(MAGE)
5 LEU A 256
LEU A 225
ILE A 221
ILE A 208
ALA A 207
None
0.93A 2i2zA-4v0pA:
undetectable
2i2zA-4v0pA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woy MITOCHONDRIAL
DYNAMICS PROTEIN
MID49


(Mus musculus)
PF03281
(Mab-21)
4 LEU A 288
ILE A 279
ILE A 156
ALA A 157
None
0.67A 2i2zA-4woyA:
2.6
2i2zA-4woyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN


(Campylobacter
jejuni)
PF07196
(Flagellin_IN)
PF07559
(FlaE)
4 LEU A 296
ILE A 346
ILE A 317
ALA A 318
None
0.77A 2i2zA-5az4A:
undetectable
2i2zA-5az4A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii)
PF00150
(Cellulase)
4 LEU A 148
ILE A  71
ILE A  96
ALA A  95
None
0.77A 2i2zA-5d9nA:
undetectable
2i2zA-5d9nA:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 LEU A 218
LEU A 259
ILE A 263
ILE A 289
ALA A 290
None
PG4  A 602 ( 4.5A)
None
PG4  A 602 ( 4.4A)
PG4  A 602 (-3.4A)
0.35A 2i2zA-5dqfA:
42.1
2i2zA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB


(Mus musculus)
PF00784
(MyTH4)
4 LEU A1436
LEU A1408
ILE A1410
ALA A1466
None
0.76A 2i2zA-5f3yA:
undetectable
2i2zA-5f3yA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 LEU A 410
LEU A 501
ILE A 548
ILE A 583
ALA A 584
None
0.95A 2i2zA-5fjjA:
undetectable
2i2zA-5fjjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5u BETA-HEXOSAMINIDASE

(Pseudomonas
aeruginosa)
PF00933
(Glyco_hydro_3)
4 LEU A  59
LEU A  14
ILE A  53
ALA A  52
None
0.70A 2i2zA-5g5uA:
undetectable
2i2zA-5g5uA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC


(Zea mays)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
4 LEU A 221
ILE A 296
ILE A 351
ALA A 350
None
0.65A 2i2zA-5h8yA:
undetectable
2i2zA-5h8yA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B


(Homo sapiens)
no annotation 4 LEU A 262
LEU A 196
ILE A 229
ALA A 218
None
0.71A 2i2zA-5hdtA:
3.9
2i2zA-5hdtA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA


(Eptatretus
burgeri;
Mus musculus)
PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8)
4 LEU A 106
LEU A  68
ILE A  92
ILE A 113
None
0.75A 2i2zA-5ijbA:
undetectable
2i2zA-5ijbA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j07 SUPEROXIDE DISMUTASE
[CU-ZN],SUPEROXIDE
DISMUTASE
[CU-ZN],SUPEROXIDE
DISMUTASE
[CU-ZN],SUPEROXIDE
DISMUTASE [CU-ZN]


(Homo sapiens)
PF00080
(Sod_Cu)
4 LEU A  65
ILE A  72
ILE A  97
ALA A  98
None
0.69A 2i2zA-5j07A:
undetectable
2i2zA-5j07A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdx PUTATIVE PEPTIDYL
CARRIER PROTEIN


(Serratia sp.)
no annotation 4 LEU A  28
LEU A   6
ILE A  10
ALA A  11
None
0.76A 2i2zA-5jdxA:
undetectable
2i2zA-5jdxA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd0 AROMATIC
PRENYLTRANSFERASE


(Aspergillus
terreus)
PF11991
(Trp_DMAT)
4 LEU A  42
LEU A 105
ILE A  92
ALA A  35
None
0.74A 2i2zA-5kd0A:
undetectable
2i2zA-5kd0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
4 LEU B 655
ILE B 714
ILE B 640
ALA B 641
None
0.67A 2i2zA-5ldrB:
undetectable
2i2zA-5ldrB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m97 MICROTUBULE
INTEGRITY PROTEIN
MAL3


(Schizosaccharomyces
pombe)
no annotation 4 LEU B  45
ILE B  42
ILE B  67
ALA B  66
None
0.78A 2i2zA-5m97B:
undetectable
2i2zA-5m97B:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN


(Segniliparus
rugosus)
PF00501
(AMP-binding)
PF00550
(PP-binding)
4 LEU A 248
LEU A 103
ILE A 142
ALA A 143
None
0.57A 2i2zA-5mswA:
2.2
2i2zA-5mswA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 5 LEU A 218
LEU A 259
ILE A 263
ILE A 289
ALA A 290
None
0.38A 2i2zA-5oriA:
40.7
2i2zA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0z LIPOPROTEIN,
PUTATIVE


(Geobacter
metallireducens)
no annotation 4 LEU A  39
LEU A 167
ILE A 171
ALA A  61
None
0.63A 2i2zA-5t0zA:
undetectable
2i2zA-5t0zA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdd BCL-2-RELATED
OVARIAN KILLER
PROTEIN


(Gallus gallus)
no annotation 4 LEU A  34
ILE A 175
ILE A  70
ALA A  69
None
0.74A 2i2zA-5wddA:
1.5
2i2zA-5wddA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whm ICLR FAMILY
TRANSCRIPTIONAL
REGULATOR


(Brucella
abortus)
PF01614
(IclR)
PF09339
(HTH_IclR)
4 LEU A  28
LEU A  79
ILE A  65
ALA A  66
None
0.61A 2i2zA-5whmA:
undetectable
2i2zA-5whmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii)
no annotation 4 LEU A 819
LEU A 776
ILE A 743
ALA A 812
None
0.78A 2i2zA-5wugA:
undetectable
2i2zA-5wugA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Colwellia
psychrerythraea)
PF00275
(EPSP_synthase)
4 LEU A 281
LEU A 394
ILE A 256
ALA A 323
None
0.76A 2i2zA-5xwbA:
undetectable
2i2zA-5xwbA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 4 LEU A 219
LEU A 260
ILE A 264
ILE A 290
None
0.43A 2i2zA-5yxeA:
37.8
2i2zA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4h NUCLEOPORIN GLE1

(Chaetomium
thermophilum)
no annotation 4 LEU A 259
ILE A 274
ILE A 354
ALA A 353
None
None
None
MES  A 604 (-2.7A)
0.78A 2i2zA-6b4hA:
undetectable
2i2zA-6b4hA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwp RIBONUCLEOTIDE
REDUCTASE


(Flavobacterium
johnsoniae)
no annotation 4 LEU A 240
ILE A 243
ILE A 170
ALA A 169
None
0.69A 2i2zA-6cwpA:
undetectable
2i2zA-6cwpA:
10.40