SIMILAR PATTERNS OF AMINO ACIDS FOR 2HZQ_A_STRA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbp BILIN BINDING
PROTEIN

(Pieris
brassicae) 		PF00061
(Lipocalin) 		4 ALA A  46
TYR A  48
TRP A 133
LEU A 135
 BLV  A 500 (-3.4A)
None
BLV  A 500 (-3.6A)
None
 0.57A 2hzqA-1bbpA:
20.4		 2hzqA-1bbpA:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 TYR A 268
ASN A 248
TRP A 246
LEU A 194
 None
 1.10A 2hzqA-1dlcA:
0.0		 2hzqA-1dlcA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		4 THR A 315
ALA A 243
PHE A 269
LEU A 392
 None
 0.95A 2hzqA-1ehkA:
undetectable		 2hzqA-1ehkA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		4 THR A  33
ALA A  53
PHE A 109
LEU A  38
 None
 1.11A 2hzqA-1fmlA:
undetectable		 2hzqA-1fmlA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		4 THR P 227
ALA P 301
PHE P 294
LEU P 121
 None
 0.99A 2hzqA-1hynP:
0.0		 2hzqA-1hynP:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7p NADH-CYTOCHROME B5
REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 THR A  56
TYR A 236
ASN A 209
LEU A 221
 None
 1.20A 2hzqA-1i7pA:
0.2		 2hzqA-1i7pA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 ALA A 271
ASN A 274
PHE A 276
LEU A 246
 None
 0.98A 2hzqA-1idjA:
undetectable		 2hzqA-1idjA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE

(Neurospora
crassa) 		PF10282
(Lactonase) 		4 THR A  46
TYR A 139
ASN A 112
LEU A 159
 None
 1.07A 2hzqA-1jofA:
0.2		 2hzqA-1jofA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m41 FMNH2-DEPENDENT
ALKANESULFONATE
MONOOXYGENASE

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		4 THR A  82
ALA A  92
PHE A 104
LEU A 161
 None
 1.15A 2hzqA-1m41A:
undetectable		 2hzqA-1m41A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Thermotoga
maritima) 		PF00171
(Aldedh) 		4 THR A 131
ALA A 150
ASN A 154
PHE A 177
 None
 1.19A 2hzqA-1o20A:
undetectable		 2hzqA-1o20A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 THR A 176
ALA A 194
TYR A 213
LEU A 233
 None
 0.87A 2hzqA-1ps9A:
undetectable		 2hzqA-1ps9A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psq PROBABLE THIOL
PEROXIDASE

(Streptococcus
pneumoniae) 		PF08534
(Redoxin) 		4 THR A  75
ALA A  22
TYR A 115
LEU A  37
 None
 1.14A 2hzqA-1psqA:
undetectable		 2hzqA-1psqA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 ALA A 271
ASN A 274
PHE A 276
LEU A 246
 None
 0.89A 2hzqA-1qcxA:
undetectable		 2hzqA-1qcxA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
subtilis) 		PF01238
(PMI_typeI) 		4 THR A   2
ALA A  52
ASN A  53
LEU A   8
 None
 1.20A 2hzqA-1qwrA:
undetectable		 2hzqA-1qwrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		4 ALA A 495
PHE A 464
TRP A 440
LEU A 376
 None
 1.14A 2hzqA-1rh1A:
undetectable		 2hzqA-1rh1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thm THERMITASE

(Thermoactinomyces
vulgaris) 		PF00082
(Peptidase_S8) 		4 THR A   2
ALA A 273
TRP A  24
LEU A 237
 None
 1.17A 2hzqA-1thmA:
undetectable		 2hzqA-1thmA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 THR B 350
TYR B 176
PHE B  52
LEU B 232
 None
 1.05A 2hzqA-1tnuB:
undetectable		 2hzqA-1tnuB:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ALA A  65
ASN A   7
TRP A  61
LEU A  62
 None
SO4  A 965 (-3.9A)
None
None
 1.15A 2hzqA-1uagA:
undetectable		 2hzqA-1uagA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 THR A 199
ALA A 170
TYR A 290
LEU A 168
 None
 1.11A 2hzqA-1uwyA:
undetectable		 2hzqA-1uwyA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uy4 ENDO-1,4-BETA-XYLANA
SE A

([Clostridium]
stercorarium) 		PF03422
(CBM_6) 		4 THR A  36
ALA A  26
TYR A  60
PHE A 130
 None
 1.18A 2hzqA-1uy4A:
undetectable		 2hzqA-1uy4A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans) 		PF01960
(ArgJ) 		4 THR A  68
ALA A  88
ASN B 237
LEU A 130
 None
 1.04A 2hzqA-1vraA:
undetectable		 2hzqA-1vraA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Pyrococcus
furiosus) 		PF00290
(Trp_syntA) 		4 THR A 156
ALA A 214
ASN A 215
PHE A   2
 None
 1.07A 2hzqA-1wdwA:
undetectable		 2hzqA-1wdwA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 THR A  15
TYR A 104
ASN A  45
PHE A 143
 None
None
ACT  A 600 ( 4.1A)
ACT  A 600 (-4.4A)
 1.11A 2hzqA-1wr8A:
undetectable		 2hzqA-1wr8A:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z24 INSECTICYANIN A FORM

(Manduca sexta) 		PF00061
(Lipocalin) 		4 ALA A  46
ASN A  59
TRP A 133
LEU A 135
 BLV  A 195 ( 3.9A)
BLV  A 195 (-3.7A)
BLV  A 195 (-3.7A)
None
 1.14A 2hzqA-1z24A:
19.5		 2hzqA-1z24A:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z24 INSECTICYANIN A FORM

(Manduca sexta) 		PF00061
(Lipocalin) 		4 ALA A  46
TYR A  48
TRP A 133
LEU A 135
 BLV  A 195 ( 3.9A)
None
BLV  A 195 (-3.7A)
None
 0.45A 2hzqA-1z24A:
19.5		 2hzqA-1z24A:
30.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE

(Alcaligenaceae
bacterium FB188) 		PF00850
(Hist_deacetyl) 		4 THR A 158
ALA A 296
PHE A 306
LEU A 253
 None
 1.09A 2hzqA-1zz3A:
undetectable		 2hzqA-1zz3A:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aco OUTER MEMBRANE
LIPOPROTEIN BLC

(Escherichia
coli) 		PF08212
(Lipocalin_2) 		5 ALA A  62
TYR A  64
ASN A  76
TRP A 139
LEU A 141
 None
 1.08A 2hzqA-2acoA:
20.0		 2hzqA-2acoA:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aky ADENYLATE KINASE

(Saccharomyces
cerevisiae) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 THR A  35
ALA A 115
TYR A 191
LEU A 112
 AP5  A 301 (-3.0A)
None
None
None
 1.12A 2hzqA-2akyA:
undetectable		 2hzqA-2akyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 THR A 399
ALA A 298
TYR A 300
PHE A 311
 None
 1.16A 2hzqA-2cvtA:
undetectable		 2hzqA-2cvtA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 THR A  72
TYR A 377
PHE A 763
LEU A 159
 None
 1.20A 2hzqA-2eaeA:
undetectable		 2hzqA-2eaeA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 THR A 634
ALA A 151
TYR A 269
PHE A 318
 None
PGE  A 777 ( 3.7A)
None
None
 1.12A 2hzqA-2f3oA:
undetectable		 2hzqA-2f3oA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggj N-ACYLAMINO ACID
RACEMASE

(Deinococcus
radiodurans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 152
ALA A 196
TYR A 200
LEU A 211
 None
 1.08A 2hzqA-2ggjA:
undetectable		 2hzqA-2ggjA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt2 GDP-MANNOSE MANNOSYL
HYDROLASE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 THR A 101
ALA A 143
ASN A 144
PHE A  47
 None
 0.95A 2hzqA-2gt2A:
undetectable		 2hzqA-2gt2A:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzr APOLIPOPROTEIN D

(Homo sapiens) 		PF08212
(Lipocalin_2) 		5 THR A  34
ALA A  44
ASN A  58
TRP A 127
LEU A 129
 None
 0.96A 2hzqA-2hzrA:
30.6		 2hzqA-2hzrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzr APOLIPOPROTEIN D

(Homo sapiens) 		PF08212
(Lipocalin_2) 		6 THR A  34
ALA A  44
TYR A  46
PHE A  89
TRP A 127
LEU A 129
 None
 0.46A 2hzqA-2hzrA:
30.6		 2hzqA-2hzrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 THR A 157
ALA A 317
ASN A 322
LEU A 216
 None
 1.18A 2hzqA-2nqnA:
undetectable		 2hzqA-2nqnA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		4 THR A 248
ALA A 154
PHE A 234
LEU A 152
 None
 1.11A 2hzqA-2vrcA:
undetectable		 2hzqA-2vrcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 THR A 283
ALA A 467
TYR A 469
PHE A 504
 None
 1.19A 2hzqA-2w8qA:
undetectable		 2hzqA-2w8qA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 THR A 233
ALA A 177
ASN A 178
LEU A 226
 None
 1.11A 2hzqA-2wyaA:
undetectable		 2hzqA-2wyaA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 145
ALA A 189
TYR A 193
LEU A 204
 None
 0.98A 2hzqA-2zc8A:
undetectable		 2hzqA-2zc8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 THR A 380
ALA A 410
TYR A 475
LEU A 393
 None
 1.00A 2hzqA-2zwsA:
undetectable		 2hzqA-2zwsA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2b SERINE
PALMITOYLTRANSFERASE

(Sphingobacterium
multivorum) 		PF00155
(Aminotran_1_2) 		4 THR A 225
TYR A 155
ASN A 158
PHE A 184
 None
 0.88A 2hzqA-3a2bA:
undetectable		 2hzqA-3a2bA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		4 ALA A 176
ASN A 180
PHE A 184
LEU A 405
 None
 0.98A 2hzqA-3b3jA:
undetectable		 2hzqA-3b3jA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		4 ALA A 288
ASN A 286
PHE A 208
LEU A  49
 None
 1.01A 2hzqA-3bh1A:
undetectable		 2hzqA-3bh1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 THR A 765
ALA A 945
TYR A 860
PHE A 937
 None
 1.05A 2hzqA-3dy5A:
1.8		 2hzqA-3dy5A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		4 THR A 233
ALA A 414
TYR A 416
PHE A 451
 None
 1.14A 2hzqA-3ek1A:
undetectable		 2hzqA-3ek1A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 THR A 765
ALA A 945
TYR A 860
PHE A 937
 None
 0.99A 2hzqA-3fg4A:
undetectable		 2hzqA-3fg4A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		4 THR A  27
ALA A  54
ASN A  55
LEU A  82
 None
None
RIB  A 305 (-3.2A)
None
 1.03A 2hzqA-3go7A:
undetectable		 2hzqA-3go7A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ALA A  32
TYR A  53
ASN A  33
LEU A 435
 None
 1.18A 2hzqA-3hn7A:
undetectable		 2hzqA-3hn7A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN
ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ BETA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		4 THR A  68
ALA A  87
ASN B 240
LEU A 134
 None
 1.07A 2hzqA-3it4A:
undetectable		 2hzqA-3it4A:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mbt OUTER MEMBRANE
LIPOPROTEIN BLC

(Escherichia
coli) 		PF08212
(Lipocalin_2) 		5 ALA A  44
TYR A  46
ASN A  58
TRP A 121
LEU A 123
 None
 1.12A 2hzqA-3mbtA:
21.1		 2hzqA-3mbtA:
31.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mbt OUTER MEMBRANE
LIPOPROTEIN BLC

(Escherichia
coli) 		PF08212
(Lipocalin_2) 		4 ALA A  44
TYR A  46
PHE A  90
LEU A 123
 None
 0.79A 2hzqA-3mbtA:
21.1		 2hzqA-3mbtA:
31.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o38 SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 THR A  35
ALA A 135
ASN A 103
LEU A  87
 None
 1.06A 2hzqA-3o38A:
undetectable		 2hzqA-3o38A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 THR A 129
ALA A  31
TYR A  66
ASN A  32
 None
 1.17A 2hzqA-3q6dA:
undetectable		 2hzqA-3q6dA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		4 THR A 261
ALA A 252
TYR A 423
PHE A 255
 None
 1.01A 2hzqA-3qa8A:
undetectable		 2hzqA-3qa8A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpm PEROXIREDOXIN

(Larimichthys
crocea) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 THR A 132
ALA A  74
TYR A 177
LEU A  92
 None
 1.10A 2hzqA-3qpmA:
undetectable		 2hzqA-3qpmA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkr PEROXIREDOXIN-4

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 THR A 106
ALA A  48
TYR A 151
LEU A  66
 None
 1.06A 2hzqA-3tkrA:
undetectable		 2hzqA-3tkrA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		4 THR A 847
ALA A 306
ASN A 767
LEU A 302
 None
None
CA  A1004 (-3.7A)
None
 1.18A 2hzqA-3tlmA:
undetectable		 2hzqA-3tlmA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus sp.
(in: Bacteria)) 		PF00180
(Iso_dh) 		4 THR A 180
ALA A 265
TYR A 275
LEU A 267
 None
 0.94A 2hzqA-3u1hA:
undetectable		 2hzqA-3u1hA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 THR A 571
ALA A 545
ASN A 402
PHE A 575
 None
 0.99A 2hzqA-3uszA:
undetectable		 2hzqA-3uszA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwv PEROXIREDOXIN-4

(Mus musculus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 THR A 146
ALA A  88
TYR A 191
LEU A 106
 None
 1.09A 2hzqA-3vwvA:
undetectable		 2hzqA-3vwvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 4 THR A  79
ALA A  67
TYR A  63
LEU A 160
 None
 0.91A 2hzqA-3w36A:
undetectable		 2hzqA-3w36A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1s PARTNER OF
INSCUTEABLE
RE60102P

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12)
no annotation 		4 THR A 307
ALA C  20
ASN A 266
PHE A 270
 None
 1.14A 2hzqA-4a1sA:
undetectable		 2hzqA-4a1sA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 THR A  51
ALA A 322
ASN A 264
PHE A 260
 None
 1.01A 2hzqA-4ccdA:
undetectable		 2hzqA-4ccdA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		4 THR A 224
TYR A 174
PHE A 111
LEU A  86
 None
None
None
G1P  A 301 ( 4.9A)
 1.03A 2hzqA-4ho4A:
undetectable		 2hzqA-4ho4A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2) 		4 THR A  15
ALA A 170
ASN A 204
LEU A  89
 None
 1.04A 2hzqA-4hppA:
undetectable		 2hzqA-4hppA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 THR A  93
TYR A  69
PHE A 204
LEU A 130
 None
 1.17A 2hzqA-4j3qA:
undetectable		 2hzqA-4j3qA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 THR A 342
ALA A 270
TYR A 271
LEU A 227
 None
 1.09A 2hzqA-4k70A:
undetectable		 2hzqA-4k70A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw2 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 THR A  73
ALA A  59
PHE A 118
LEU A  46
 None
 1.14A 2hzqA-4kw2A:
undetectable		 2hzqA-4kw2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky9 BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		4 THR A 227
ALA A 301
PHE A 294
LEU A 121
 None
 0.97A 2hzqA-4ky9A:
undetectable		 2hzqA-4ky9A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 THR A  81
ALA A 245
ASN A 273
PHE A 157
 None
COA  A 401 (-3.3A)
COA  A 401 (-3.7A)
COA  A 401 (-4.6A)
 1.20A 2hzqA-4nhdA:
undetectable		 2hzqA-4nhdA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8x URICASE

(Bacillus
fastidiosus) 		PF01014
(Uricase) 		4 THR A 145
ASN A 266
TRP A 206
LEU A 262
 None
 1.07A 2hzqA-4r8xA:
undetectable		 2hzqA-4r8xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 4 THR B  87
ALA B  96
PHE B  35
LEU B 116
 None
 1.01A 2hzqA-4xsrB:
undetectable		 2hzqA-4xsrB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		4 THR A  85
ALA A 100
PHE A 213
LEU A  96
 None
EPE  A 403 (-3.6A)
EPE  A 403 (-4.8A)
None
 1.02A 2hzqA-4y0eA:
undetectable		 2hzqA-4y0eA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 4 THR A1598
ALA A1158
TYR A1150
PHE A1219
 None
 0.98A 2hzqA-5b2oA:
undetectable		 2hzqA-5b2oA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f22 NON-STRUCTURAL
PROTEIN

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF08717
(nsp8) 		4 THR B 142
ALA B 155
ASN B 110
LEU B 133
 None
 0.98A 2hzqA-5f22B:
undetectable		 2hzqA-5f22B:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 THR A 244
ASN A 268
PHE A 349
LEU A 177
 None
 1.05A 2hzqA-5f7uA:
undetectable		 2hzqA-5f7uA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftw CHEMOTAXIS PROTEIN
METHYLTRANSFERASE

(Bacillus
subtilis) 		PF01739
(CheR)
PF03705
(CheR_N) 		4 THR A  65
TYR A 191
ASN A 185
LEU A 215
 SAH  A1257 (-3.6A)
None
SAH  A1257 (-3.8A)
None
 1.10A 2hzqA-5ftwA:
undetectable		 2hzqA-5ftwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 THR A 131
ALA A 368
TYR A 253
LEU A  89
 None
 1.14A 2hzqA-5gj8A:
undetectable		 2hzqA-5gj8A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 THR A1132
ALA A1250
PHE A1125
LEU A 201
 PC1  A1912 (-4.3A)
None
None
None
 1.13A 2hzqA-5gjvA:
undetectable		 2hzqA-5gjvA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF09427
(DUF2014) 		4 THR A 863
ALA A 837
TYR A 814
PHE A 791
 None
 1.04A 2hzqA-5gpdA:
undetectable		 2hzqA-5gpdA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 4 ALA A 333
ASN A 402
PHE A 404
LEU A 280
 None
 1.06A 2hzqA-5gt5A:
undetectable		 2hzqA-5gt5A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hoe HYDROLASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		4 THR A 190
ALA A  57
ASN A  96
PHE A 156
 None
PO4  A 301 (-4.0A)
PO4  A 301 (-3.0A)
None
 1.15A 2hzqA-5hoeA:
undetectable		 2hzqA-5hoeA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		4 THR B 325
ALA B 389
ASN B 392
LEU B 363
 None
 0.93A 2hzqA-5hz1B:
undetectable		 2hzqA-5hz1B:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		4 THR A 226
TYR A 176
PHE A 113
LEU A  88
 None
None
None
TRH  A 500 (-4.6A)
 1.00A 2hzqA-5ifyA:
undetectable		 2hzqA-5ifyA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		4 THR A 118
ALA A 183
TYR A 214
LEU A 187
 None
 1.05A 2hzqA-5j55A:
undetectable		 2hzqA-5j55A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo9 RIBITOL
2-DEHYDROGENASE

(Bradyrhizobium
japonicum) 		PF00106
(adh_short) 		4 THR A  13
TYR A 153
ASN A 112
LEU A 190
 None
SOR  A 302 (-3.9A)
None
PO4  A 301 (-4.4A)
 1.19A 2hzqA-5jo9A:
undetectable		 2hzqA-5jo9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mo9 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07679
(I-set) 		4 ALA X 376
TYR X 359
ASN X 356
LEU X 348
 None
 1.12A 2hzqA-5mo9X:
undetectable		 2hzqA-5mo9X:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 4 THR A 230
TYR A 141
ASN A 192
LEU A 110
 None
None
None
PLM  A 401 ( 4.4A)
 1.18A 2hzqA-5oceA:
undetectable		 2hzqA-5oceA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 ALA T3081
TYR T3085
ASN T3064
LEU T3107
 None
 0.91A 2hzqA-5ojsT:
undetectable		 2hzqA-5ojsT:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 4 THR A  93
TYR A  69
PHE A 204
LEU A 130
 None
 1.15A 2hzqA-5or4A:
undetectable		 2hzqA-5or4A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 THR A 205
ALA A 136
TYR A 147
PHE A 192
 None
None
NAP  A 301 (-4.4A)
None
 1.16A 2hzqA-5t2uA:
undetectable		 2hzqA-5t2uA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxb PROXP-ALA

(Caulobacter
vibrioides) 		PF04073
(tRNA_edit) 		4 THR A  65
ALA A 102
ASN A  46
LEU A 145
 None
 1.05A 2hzqA-5vxbA:
undetectable		 2hzqA-5vxbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 THR A 511
ALA A 483
PHE A 470
LEU A 485
 None
 1.17A 2hzqA-5xh9A:
undetectable		 2hzqA-5xh9A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 THR A 515
ALA A 399
TYR A 425
ASN A 437
 None
 1.13A 2hzqA-5yj6A:
undetectable		 2hzqA-5yj6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2v SORB

(Sorangium
cellulosum) 		no annotation 4 THR A 262
ALA A 101
TYR A  91
LEU A  43
 None
 1.05A 2hzqA-6b2vA:
undetectable		 2hzqA-6b2vA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 4 THR A 223
TYR A 173
PHE A 111
LEU A  86
 None
None
None
DAU  A 301 (-4.8A)
 1.12A 2hzqA-6b5eA:
undetectable		 2hzqA-6b5eA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 4 THR A1132
ALA A1250
PHE A1125
LEU A 201
 None
 1.13A 2hzqA-6byoA:
undetectable		 2hzqA-6byoA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1 -

(-) 		no annotation 4 THR D 209
ALA D 149
TYR D  72
ASN D 115
 None
 1.15A 2hzqA-6dw1D:
undetectable		 2hzqA-6dw1D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 8

(Mus musculus) 		no annotation 4 ALA X  66
TYR X  31
ASN X  63
LEU X  24
 None
 1.20A 2hzqA-6g72X:
undetectable		 2hzqA-6g72X:
16.95