SIMILAR PATTERNS OF AMINO ACIDS FOR 2HYY_D_STID600_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 267
LYS A 290
VAL A 318
MET A 337
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
None
 0.58A 2hyyD-1opkA:
34.8		 2hyyD-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
LYS X  39
VAL X  67
MET X  85
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
None
 0.62A 2hyyD-2dq7X:
32.2		 2hyyD-2dq7X:
46.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 323
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.87A 2hyyD-2hckA:
30.2		 2hyyD-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
LYS A 273
VAL A 301
MET A 319
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
None
 0.80A 2hyyD-2hk5A:
27.5		 2hyyD-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 724
LYS A 751
VAL A 781
MET A 799
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
None
 1.03A 2hyyD-2r4bA:
29.7		 2hyyD-2r4bA:
38.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
VAL A 113
MET A 132
 STU  A   1 (-3.8A)
STU  A   1 ( 4.2A)
None
None
 0.61A 2hyyD-3fmeA:
17.5		 2hyyD-3fmeA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1005
LYS A1033
VAL A1063
MET A1082
 None
CCX  A   1 ( 3.7A)
CCX  A   1 (-4.1A)
None
 0.84A 2hyyD-3lw0A:
32.5		 2hyyD-3lw0A:
44.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 544
LYS A 572
VAL A 601
MET A 620
 0F4  A 902 ( 4.2A)
0F4  A 902 (-4.0A)
None
None
 0.82A 2hyyD-3v5qA:
29.0		 2hyyD-3v5qA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
VAL A 113
MET A 132
 None
ANK  A 401 (-2.4A)
None
None
 1.18A 2hyyD-3vn9A:
22.1		 2hyyD-3vn9A:
26.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 560
LYS A 588
VAL A 617
MET A 636
 LTI  A1839 ( 4.2A)
None
None
None
 0.78A 2hyyD-4at3A:
28.0		 2hyyD-4at3A:
36.77