SIMILAR PATTERNS OF AMINO ACIDS FOR 2HYY_C_STIC600_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		4 LEU A 136
VAL A 112
MET A  11
ILE A  93
 None
 1.16A 2hyyC-1c9eA:
undetectable		 2hyyC-1c9eA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 LEU C 211
VAL C 359
MET C 343
ILE C 380
 None
 1.10A 2hyyC-1d7wC:
undetectable		 2hyyC-1d7wC:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gom ENDO-1,4-BETA-XYLANA
SE

(Thermoascus
aurantiacus) 		PF00331
(Glyco_hydro_10) 		4 LEU A 139
VAL A 107
MET A 108
ILE A 148
 None
 1.13A 2hyyC-1gomA:
undetectable		 2hyyC-1gomA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 248
LYS A 251
VAL A  58
MET A  95
 None
 0.93A 2hyyC-1iovA:
undetectable		 2hyyC-1iovA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LEU A 245
VAL A 323
ILE A 300
MET A  82
 None
 1.14A 2hyyC-1jr1A:
undetectable		 2hyyC-1jr1A:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 239
MET A 240
ILE A 264
 None
 0.45A 2hyyC-1k9aA:
31.3		 2hyyC-1k9aA:
30.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 239
MET A 240
ILE A 264
MET A 269
 None
 0.58A 2hyyC-1k9aA:
31.3		 2hyyC-1k9aA:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		4 LEU A  28
VAL A 137
ILE A  93
MET A  74
 None
 1.17A 2hyyC-1o60A:
undetectable		 2hyyC-1o60A:
18.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
LYS A 290
VAL A 308
MET A 309
ILE A 332
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
 0.53A 2hyyC-1opkA:
35.2		 2hyyC-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
VAL A 308
MET A 309
ILE A 332
MET A 337
 P16  A   2 ( 4.2A)
None
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
None
 0.44A 2hyyC-1opkA:
35.2		 2hyyC-1opkA:
99.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		4 LEU A 189
VAL A 266
ILE A 272
MET A 217
 None
 1.01A 2hyyC-1un9A:
undetectable		 2hyyC-1un9A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		4 LEU A  91
VAL A 378
MET A 379
ILE A 139
 None
 1.10A 2hyyC-1xr4A:
undetectable		 2hyyC-1xr4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.06A 2hyyC-1ycnA:
undetectable		 2hyyC-1ycnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 177
VAL A 290
ILE A 201
MET A 224
 None
 1.12A 2hyyC-1zklA:
undetectable		 2hyyC-1zklA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8j FERROCHELATASE 1

(Bacillus
anthracis) 		PF00762
(Ferrochelatase) 		4 LEU A 135
VAL A 111
MET A  10
ILE A  92
 None
 1.13A 2hyyC-2c8jA:
undetectable		 2hyyC-2c8jA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwe HYPOTHETICAL
TRANSCRIPTION
REGULATOR PROTEIN,
PH1932

(Pyrococcus
horikoshii) 		PF01022
(HTH_5) 		4 LYS A   6
VAL A  16
MET A  17
ILE A   8
 None
 1.01A 2hyyC-2cweA:
undetectable		 2hyyC-2cweA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
LYS X  39
MET X  58
ILE X  80
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
None
 0.53A 2hyyC-2dq7X:
32.5		 2hyyC-2dq7X:
46.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
MET X  58
ILE X  80
MET X  85
 STU  X 902 (-3.8A)
None
None
None
 0.50A 2hyyC-2dq7X:
32.5		 2hyyC-2dq7X:
46.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
LYS A 186
VAL A 204
ILE A 234
 None
 0.78A 2hyyC-2eu9A:
22.0		 2hyyC-2eu9A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.91A 2hyyC-2hckA:
30.4		 2hyyC-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
LYS A 273
VAL A 291
MET A 292
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
 0.61A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 291
MET A 292
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
None
 0.65A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
LYS A 271
VAL A 289
MET A 290
ILE A 313
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
 0.80A 2hyyC-2hz0A:
35.5		 2hyyC-2hz0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 289
MET A 290
ILE A 313
MET A 318
 GIN  A 600 ( 4.6A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
None
 0.38A 2hyyC-2hz0A:
35.5		 2hyyC-2hz0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A 744
VAL A 798
MET A 797
ILE A 751
 None
 1.13A 2hyyC-2i1yA:
undetectable		 2hyyC-2i1yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipp CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU B 181
VAL B 246
ILE B 201
MET B 195
 None
 1.15A 2hyyC-2ippB:
undetectable		 2hyyC-2ippB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		4 LEU G  78
MET G 112
ILE G  66
MET G 302
 None
 1.16A 2hyyC-2nzuG:
undetectable		 2hyyC-2nzuG:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN

(Archaeoglobus
fulgidus) 		PF00437
(T2SSE) 		4 LEU 1 253
VAL 1 373
MET 1 372
ILE 1 264
 None
 0.90A 2hyyC-2oap1:
undetectable		 2hyyC-2oap1:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
LYS A 273
MET A 292
ILE A 314
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
 0.99A 2hyyC-2og8A:
32.6		 2hyyC-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
MET A 292
ILE A 314
MET A 319
 None
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
 0.71A 2hyyC-2og8A:
32.6		 2hyyC-2og8A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 LEU A 276
VAL A 165
MET A 168
ILE A 210
 None
 1.17A 2hyyC-2qagA:
undetectable		 2hyyC-2qagA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 190
VAL A 217
MET A 218
ILE A 197
 None
 1.13A 2hyyC-2vawA:
undetectable		 2hyyC-2vawA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A  15
VAL A 303
MET A 302
ILE A 389
 None
 1.17A 2hyyC-2vqdA:
undetectable		 2hyyC-2vqdA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 653
MET A 674
ILE A 697
MET A 702
 Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
None
 0.50A 2hyyC-2xyuA:
32.7		 2hyyC-2xyuA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1002
VAL A1050
MET A1051
MET A1079
 S91  A   1 ( 4.1A)
None
None
None
 0.68A 2hyyC-2z8cA:
29.6		 2hyyC-2z8cA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 253
LYS A 275
MET A 294
ILE A 317
 None
 0.95A 2hyyC-2zv7A:
26.3		 2hyyC-2zv7A:
46.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 239
MET A 240
ILE A 264
 None
 0.45A 2hyyC-3d7uA:
27.3		 2hyyC-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 239
MET A 240
ILE A 264
MET A 269
 None
 0.58A 2hyyC-3d7uA:
27.3		 2hyyC-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LYS A 665
MET A 686
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.5A)
None
None
 0.72A 2hyyC-3dkoA:
31.5		 2hyyC-3dkoA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
ILE A 127
MET A 132
 STU  A   1 (-3.8A)
STU  A   1 ( 4.2A)
None
None
 0.50A 2hyyC-3fmeA:
17.3		 2hyyC-3fmeA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 4 LEU K 738
MET K 775
ILE K 756
MET K 718
 None
 1.07A 2hyyC-3jblK:
undetectable		 2hyyC-3jblK:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9m CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU A 181
VAL A 246
ILE A 201
MET A 195
 None
 1.10A 2hyyC-3k9mA:
undetectable		 2hyyC-3k9mA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		4 LEU A 130
VAL A 182
MET A 181
ILE A 166
 None
 1.16A 2hyyC-3krvA:
undetectable		 2hyyC-3krvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		4 LEU A 158
VAL A 182
MET A 181
ILE A 166
 None
 1.09A 2hyyC-3krvA:
undetectable		 2hyyC-3krvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 LEU A 375
LYS A 368
ILE A 245
MET A 254
 None
 1.07A 2hyyC-3maxA:
undetectable		 2hyyC-3maxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacteroides
thetaiotaomicron) 		PF08543
(Phos_pyr_kin) 		4 LEU A  40
VAL A 129
MET A 128
ILE A  91
 None
 1.01A 2hyyC-3mbhA:
undetectable		 2hyyC-3mbhA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN

(Paraburkholderia
xenovorans) 		PF13458
(Peripla_BP_6) 		4 VAL A 197
MET A 168
ILE A 221
MET A 267
 None
 0.95A 2hyyC-3n0wA:
undetectable		 2hyyC-3n0wA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  88
LYS A 111
VAL A 133
MET A 134
 JOZ  A 361 (-4.1A)
SO4  A   5 (-2.8A)
None
None
 0.87A 2hyyC-3nuuA:
23.3		 2hyyC-3nuuA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 VAL A  33
MET A  34
ILE A  94
MET A 299
 None
 1.02A 2hyyC-3nwrA:
undetectable		 2hyyC-3nwrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 LEU A  79
MET A 113
ILE A  67
MET A 303
 None
 1.09A 2hyyC-3oqnA:
undetectable		 2hyyC-3oqnA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 LEU A 298
VAL A 407
ILE A 358
MET A 319
 None
 1.05A 2hyyC-3oqqA:
undetectable		 2hyyC-3oqqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 LEU A 175
VAL A  70
MET A  71
ILE A 188
 None
 0.98A 2hyyC-3r75A:
undetectable		 2hyyC-3r75A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 LEU A 390
VAL A  70
MET A  71
ILE A 188
 None
 1.06A 2hyyC-3r75A:
undetectable		 2hyyC-3r75A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE

(Cytophaga
hutchinsonii) 		PF00480
(ROK) 		4 LEU A 114
VAL A 239
MET A 240
ILE A 129
 None
 1.11A 2hyyC-3r8eA:
undetectable		 2hyyC-3r8eA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 345
LYS A 368
VAL A 387
MET A 388
 STU  A   1 (-3.8A)
STU  A   1 (-3.1A)
None
None
 0.88A 2hyyC-3s95A:
24.5		 2hyyC-3s95A:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8k UNCHARACTERIZED
PROTEIN

(Leptotrichia
buccalis) 		no annotation 4 LEU A 132
LYS A  95
MET A  56
ILE A  96
 None
 1.03A 2hyyC-3t8kA:
undetectable		 2hyyC-3t8kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
ILE A 127
MET A 132
 None
ANK  A 401 (-2.4A)
None
None
 0.82A 2hyyC-3vn9A:
22.2		 2hyyC-3vn9A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		4 LEU A 497
VAL A 974
MET A 975
ILE A 410
 None
 1.08A 2hyyC-3w9iA:
undetectable		 2hyyC-3w9iA:
12.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
LYS A 655
MET A 676
MET A 704
 None
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
None
 0.95A 2hyyC-4ckrA:
32.2		 2hyyC-4ckrA:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF06187
(DUF993) 		4 LEU A 200
VAL A 242
MET A 243
ILE A 232
 None
 1.04A 2hyyC-4dnhA:
undetectable		 2hyyC-4dnhA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 LEU A 268
VAL A  23
ILE A  11
MET A 414
 None
 1.14A 2hyyC-4dshA:
undetectable		 2hyyC-4dshA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 187
VAL A 214
MET A 215
ILE A 194
 None
 1.14A 2hyyC-4e6eA:
undetectable		 2hyyC-4e6eA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		4 LEU A  36
VAL A  99
ILE A  74
MET A   1
 None
 1.17A 2hyyC-4eysA:
undetectable		 2hyyC-4eysA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 377
LYS A 402
VAL A 423
MET A 424
 0SB  A 701 ( 3.9A)
0SB  A 701 ( 4.8A)
None
None
 0.76A 2hyyC-4f4pA:
30.7		 2hyyC-4f4pA:
40.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		4 LEU A 131
VAL A 218
MET A 219
ILE A  87
 None
 1.15A 2hyyC-4jzxA:
undetectable		 2hyyC-4jzxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  33
LYS A  56
MET A  74
ILE A  97
 GOL  A 404 ( 3.6A)
GOL  A 403 ( 4.6A)
None
None
 1.00A 2hyyC-4lg4A:
17.8		 2hyyC-4lg4A:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
LYS A 295
VAL A 313
MET A 314
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
 0.84A 2hyyC-4lggA:
30.2		 2hyyC-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 313
MET A 314
ILE A 336
MET A 341
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
None
 0.85A 2hyyC-4lggA:
30.2		 2hyyC-4lggA:
47.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 LEU A  53
LYS A  76
MET A  98
MET A 133
 046  A 401 ( 3.9A)
046  A 401 ( 4.7A)
046  A 401 (-3.5A)
None
 0.91A 2hyyC-4o2zA:
22.1		 2hyyC-4o2zA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 LEU A 281
VAL A 237
ILE A 244
MET A 106
 None
 1.04A 2hyyC-4uoeA:
undetectable		 2hyyC-4uoeA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
LYS A  74
MET A  94
ILE A 124
 KSA  A 405 ( 4.0A)
None
None
None
 0.67A 2hyyC-4wsqA:
23.0		 2hyyC-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 LYS A 294
VAL A 288
ILE A 292
MET A 179
 None
 0.97A 2hyyC-4x8rA:
undetectable		 2hyyC-4x8rA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 473
LYS A 503
VAL A 523
MET A 524
 40M  A1002 ( 4.6A)
40M  A1002 (-4.0A)
None
40M  A1002 (-3.8A)
 0.80A 2hyyC-4xcuA:
31.4		 2hyyC-4xcuA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 LEU B 267
LYS B 290
VAL B 308
MET B 309
ILE B 332
 1N1  B 601 (-3.7A)
1N1  B 601 (-4.6A)
None
1N1  B 601 (-3.7A)
1N1  B 601 (-4.1A)
 0.88A 2hyyC-4xeyB:
36.1		 2hyyC-4xeyB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 LEU B 267
VAL B 308
MET B 309
ILE B 332
MET B 337
 1N1  B 601 (-3.7A)
None
1N1  B 601 (-3.7A)
1N1  B 601 (-4.1A)
None
 0.61A 2hyyC-4xeyB:
36.1		 2hyyC-4xeyB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 4 LEU E 293
VAL E 335
ILE E 331
MET E 259
 None
 1.16A 2hyyC-4xmmE:
undetectable		 2hyyC-4xmmE:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		4 LEU B 136
VAL B 223
MET B 224
ILE B  92
 None
 1.12A 2hyyC-5ahuB:
undetectable		 2hyyC-5ahuB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A 127
VAL A 200
MET A 201
ILE A  80
 None
 0.99A 2hyyC-5e8kA:
undetectable		 2hyyC-5e8kA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 LEU A  62
VAL A 464
MET A 463
ILE A 491
 None
 1.05A 2hyyC-5ev7A:
undetectable		 2hyyC-5ev7A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		4 VAL A 482
MET A 483
ILE A 536
MET A 522
 None
 1.15A 2hyyC-5fgnA:
undetectable		 2hyyC-5fgnA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
LYS A 627
MET A 648
ILE A 672
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
 0.81A 2hyyC-5grnA:
29.6		 2hyyC-5grnA:
36.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 LEU A  97
MET A 495
ILE A 708
MET A  93
 None
 1.06A 2hyyC-5h53A:
undetectable		 2hyyC-5h53A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  57
LYS A  79
MET A  99
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 ( 4.8A)
None
None
 0.48A 2hyyC-5i3oA:
22.6		 2hyyC-5i3oA:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 718
LYS A 745
VAL A 765
MET A 766
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.1A)
 0.55A 2hyyC-5j9zA:
30.4		 2hyyC-5j9zA:
36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 718
VAL A 765
MET A 766
MET A 793
 6HJ  A1101 ( 4.6A)
None
6HJ  A1101 ( 4.1A)
None
 0.94A 2hyyC-5j9zA:
30.4		 2hyyC-5j9zA:
36.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Rhinovirus C) 		PF00073
(Rhv) 		4 LEU B  25
VAL A 121
ILE A 130
MET A 204
 None
 1.15A 2hyyC-5k0uB:
undetectable		 2hyyC-5k0uB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 LEU A 511
VAL A  57
MET A  58
ILE A  36
 None
 1.04A 2hyyC-5kgnA:
undetectable		 2hyyC-5kgnA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 665
MET A 686
ILE A 709
MET A 714
 None
6P6  A1001 ( 4.2A)
6P6  A1001 ( 4.5A)
None
 0.69A 2hyyC-5l6oA:
33.3		 2hyyC-5l6oA:
38.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 LEU A 377
VAL A 525
MET A 509
ILE A 546
 None
 1.17A 2hyyC-5mfaA:
undetectable		 2hyyC-5mfaA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 LEU A 114
VAL A 369
ILE A  36
MET A 153
 None
 1.09A 2hyyC-5x2qA:
undetectable		 2hyyC-5x2qA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zm4 DIOXYGENASE ANDA

(Aspergillus
stellatus) 		no annotation 4 VAL A  54
MET A  55
ILE A 225
MET A  73
 None
None
None
9FU  A 303 ( 4.5A)
 1.17A 2hyyC-5zm4A:
undetectable		 2hyyC-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 LEU A 377
VAL A 525
MET A 509
ILE A 546
 None
 1.13A 2hyyC-6azpA:
undetectable		 2hyyC-6azpA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 4 LEU A 150
VAL A  83
ILE A 116
MET A 245
 None
 1.16A 2hyyC-6b5fA:
undetectable		 2hyyC-6b5fA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 4 LEU E1519
VAL E1550
ILE E1535
MET E1524
 None
 1.17A 2hyyC-6c3pE:
undetectable		 2hyyC-6c3pE:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE

(Proteus
mirabilis) 		no annotation 4 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 1.03A 2hyyC-6cn0A:
undetectable		 2hyyC-6cn0A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 4 LEU A 197
LYS A 219
ILE A 262
MET A 267
 FKY  A9001 (-4.1A)
None
None
None
 1.03A 2hyyC-6cz4A:
22.2		 2hyyC-6cz4A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 LEU A1084
LYS A 787
VAL A 925
ILE A 800
 None
 1.00A 2hyyC-6en4A:
undetectable		 2hyyC-6en4A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 LEU A 169
LYS A 193
VAL A 211
ILE A 241
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.0A)
None
None
 0.65A 2hyyC-6fylA:
22.2		 2hyyC-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.66A 2hyyC-6fyoA:
21.9		 2hyyC-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.71A 2hyyC-6fyvA:
22.1		 2hyyC-6fyvA:
undetectable