SIMILAR PATTERNS OF AMINO ACIDS FOR 2HYY_C_STIC600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
LEU A 133
ALA A 143
 None
 0.76A 2hyyC-1h4lA:
23.8		 2hyyC-1h4lA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
GLU A 236
VAL A 249
THR A 266
GLY A 272
LEU A 321
 None
 0.66A 2hyyC-1k9aA:
31.3		 2hyyC-1k9aA:
30.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 588
ALA A 606
VAL A 638
GLY A 660
LEU A 731
ALA A 741
ASP A 742
 None
 0.76A 2hyyC-1lufA:
30.2		 2hyyC-1lufA:
37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		11 TYR A 272
VAL A 275
ALA A 288
GLU A 305
ILE A 312
VAL A 318
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.84A 2hyyC-1opkA:
35.2		 2hyyC-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
GLY A 676
LEU A 799
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.55A 2hyyC-1t46A:
29.4		 2hyyC-1t46A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 352
ALA A 367
GLU A 386
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.45A 2hyyC-1u59A:
31.0		 2hyyC-1u59A:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.84A 2hyyC-2bujA:
23.2		 2hyyC-2bujA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL X  25
ALA X  37
GLU X  54
VAL X  67
THR X  82
GLY X  88
LEU X 137
ALA X 147
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.65A 2hyyC-2dq7X:
32.6		 2hyyC-2dq7X:
46.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 170
ALA A 184
GLU A 201
ILE A 208
VAL A 220
LEU A 290
ALA A 319
 None
 0.73A 2hyyC-2eu9A:
22.0		 2hyyC-2eu9A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 170
ALA A 184
GLU A 201
VAL A 220
GLY A 240
LEU A 290
ALA A 319
 None
 1.04A 2hyyC-2eu9A:
22.0		 2hyyC-2eu9A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.81A 2hyyC-2h8hA:
31.0		 2hyyC-2h8hA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 293
VAL A 323
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.63A 2hyyC-2hckA:
30.4		 2hyyC-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
VAL A 323
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.83A 2hyyC-2hckA:
30.4		 2hyyC-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 259
ALA A 271
GLU A 288
VAL A 301
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.89A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 259
ALA A 271
VAL A 301
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.72A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 259
ALA A 271
VAL A 301
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.80A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 269
GLU A 286
ILE A 293
VAL A 299
THR A 315
PHE A 317
GLY A 321
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.74A 2hyyC-2hz0A:
35.5		 2hyyC-2hz0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 256
ALA A 269
GLU A 286
ILE A 293
VAL A 299
THR A 315
PHE A 317
GLY A 321
LEU A 370
ALA A 380
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.55A 2hyyC-2hz0A:
35.5		 2hyyC-2hz0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
LEU A 134
ALA A 144
 None
 0.65A 2hyyC-2jgzA:
23.4		 2hyyC-2jgzA:
27.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
GLU A 288
VAL A 301
THR A 316
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.54A 2hyyC-2og8A:
32.6		 2hyyC-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 596
ALA A 614
GLU A 633
VAL A 647
THR A 663
GLY A 669
LEU A 785
ASP A 796
 None
 0.80A 2hyyC-2ogvA:
32.5		 2hyyC-2ogvA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 838
ALA A 853
GLY A 908
LEU A 971
ALA A 981
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 ( 3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.45A 2hyyC-2p4iA:
23.9		 2hyyC-2p4iA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
ALA A 515
GLU A 534
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.65A 2hyyC-2psqA:
32.4		 2hyyC-2psqA:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 1.19A 2hyyC-2qluA:
24.9		 2hyyC-2qluA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.63A 2hyyC-2qluA:
24.9		 2hyyC-2qluA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 103
ILE A 127
VAL A 137
GLY A 158
LEU A 205
ALA A 215
ASP A 216
 ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 1.27A 2hyyC-2v55A:
17.8		 2hyyC-2v55A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 103
ILE A 127
VAL A 137
GLY A 159
LEU A 205
ALA A 215
ASP A 216
 ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 1.19A 2hyyC-2v55A:
17.8		 2hyyC-2v55A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  90
ALA A 103
ILE A 127
VAL A 137
GLY A 159
LEU A 205
ALA A 215
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 1.21A 2hyyC-2v55A:
17.8		 2hyyC-2v55A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  85
GLU B 118
VAL B 131
THR B 147
PHE B 149
GLY B 153
LEU B 202
 ANP  B 432 (-4.6A)
None
None
ANP  B 432 (-4.3A)
ANP  B 432 ( 4.9A)
ANP  B 432 ( 4.2A)
ANP  B 432 ( 4.7A)
 0.80A 2hyyC-2wtkB:
22.5		 2hyyC-2wtkB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  76
ALA A  92
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.43A 2hyyC-2z7rA:
21.9		 2hyyC-2z7rA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
GLU A 290
VAL A 303
THR A 319
PHE A 321
ASP A 385
 None
 0.93A 2hyyC-2zv7A:
26.3		 2hyyC-2zv7A:
46.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
VAL A 303
THR A 319
PHE A 321
ALA A 384
ASP A 385
 None
 0.75A 2hyyC-2zv7A:
26.3		 2hyyC-2zv7A:
46.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 261
ALA A 273
VAL A 303
THR A 319
PHE A 321
GLY A 325
LEU A 374
ALA A 384
 None
 0.83A 2hyyC-2zv7A:
26.3		 2hyyC-2zv7A:
46.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.63A 2hyyC-3c4fA:
31.7		 2hyyC-3c4fA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
GLU A 236
VAL A 249
THR A 266
GLY A 272
LEU A 321
 None
 0.66A 2hyyC-3d7uA:
27.3		 2hyyC-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
ALA A 663
VAL A 695
PHE A 713
GLY A 717
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.74A 2hyyC-3dkoA:
31.5		 2hyyC-3dkoA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
None
 0.87A 2hyyC-3hngA:
33.4		 2hyyC-3hngA:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
VAL A 113
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 0.85A 2hyyC-3iecA:
22.7		 2hyyC-3iecA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 VAL A 566
ALA A 579
GLU A 596
ILE A 603
VAL A 614
GLY A 634
LEU A 684
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
None
 1.05A 2hyyC-3lltA:
21.4		 2hyyC-3lltA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  33
ALA A  46
GLU A  66
VAL A  79
PHE A 105
LEU A 156
ALA A 166
 None
 0.65A 2hyyC-3mi9A:
16.2		 2hyyC-3mi9A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 216
ALA A 227
ILE A 245
THR A 277
GLY A 283
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 ( 3.8A)
None
 1.37A 2hyyC-3my0A:
25.2		 2hyyC-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 216
ALA A 227
THR A 277
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.85A 2hyyC-3my0A:
25.2		 2hyyC-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  37
ALA A  49
GLU A  69
VAL A  82
PHE A 100
LEU A 151
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.6A)
None
 0.77A 2hyyC-3nizA:
23.2		 2hyyC-3nizA:
26.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
GLU A 596
VAL A 609
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.51A 2hyyC-3ppzA:
29.2		 2hyyC-3ppzA:
33.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.61A 2hyyC-3q4tA:
24.4		 2hyyC-3q4tA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.70A 2hyyC-3q5iA:
20.3		 2hyyC-3q5iA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
None
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.61A 2hyyC-3tt0A:
30.9		 2hyyC-3tt0A:
40.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 382
GLU A 403
PHE A 435
GLY A 439
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 1.19A 2hyyC-3txoA:
18.2		 2hyyC-3txoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 382
ILE A 406
PHE A 435
GLY A 439
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
None
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 1.11A 2hyyC-3txoA:
18.2		 2hyyC-3txoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 369
ALA A 382
GLU A 403
PHE A 435
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.82A 2hyyC-3txoA:
18.2		 2hyyC-3txoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 369
ALA A 382
ILE A 406
PHE A 435
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 1.08A 2hyyC-3txoA:
18.2		 2hyyC-3txoA:
24.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.72A 2hyyC-3vidA:
30.8		 2hyyC-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.64A 2hyyC-3wzdA:
31.9		 2hyyC-3wzdA:
38.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
GLU A  50
VAL A  63
PHE A  81
LEU A 132
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.54A 2hyyC-3zduA:
22.6		 2hyyC-3zduA:
26.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.80A 2hyyC-4agdA:
33.0		 2hyyC-4agdA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 105
ALA A 121
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.51A 2hyyC-4aw5A:
27.1		 2hyyC-4aw5A:
39.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 TYR A  15
VAL A  18
ALA A  31
VAL A  64
PHE A  82
LEU A 133
 TC0  A 500 (-4.0A)
None
TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-4.2A)
TC0  A 500 (-4.3A)
 0.53A 2hyyC-4bbmA:
22.2		 2hyyC-4bbmA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  50
ALA A  63
GLU A  81
VAL A  94
PHE A 112
GLY A 116
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.61A 2hyyC-4bc6A:
22.1		 2hyyC-4bc6A:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
ILE A  84
PHE A 112
GLY A 116
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
None
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 1.01A 2hyyC-4bc6A:
22.1		 2hyyC-4bc6A:
29.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 653
GLU A 672
THR A 701
GLY A 707
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.57A 2hyyC-4ckrA:
32.2		 2hyyC-4ckrA:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.61A 2hyyC-4crsA:
21.0		 2hyyC-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 671
ALA A 684
ILE A 708
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 1.01A 2hyyC-4crsA:
21.0		 2hyyC-4crsA:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		7 VAL A1040
ALA A1053
GLU A1078
VAL A1091
PHE A1107
GLY A1111
ALA A1176
 None
 0.83A 2hyyC-4f0gA:
26.8		 2hyyC-4f0gA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		7 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.80A 2hyyC-4fieA:
22.3		 2hyyC-4fieA:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 836
ALA A 853
GLU A 871
VAL A 884
GLY A 908
LEU A 956
ALA A 966
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.55A 2hyyC-4hviA:
30.3		 2hyyC-4hviA:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 486
ALA A 506
GLU A 525
ILE A 532
GLY A 561
LEU A 624
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
None
 0.81A 2hyyC-4k33A:
26.4		 2hyyC-4k33A:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
GLU A  70
VAL A  83
GLY A 105
LEU A 153
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 403 (-4.1A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 1.09A 2hyyC-4lg4A:
17.7		 2hyyC-4lg4A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
GLU B  70
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.89A 2hyyC-4o27B:
18.4		 2hyyC-4o27B:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.95A 2hyyC-4o38A:
19.7		 2hyyC-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.63A 2hyyC-4o38A:
19.7		 2hyyC-4o38A:
24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.63A 2hyyC-4rt7A:
29.0		 2hyyC-4rt7A:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
ILE A  55
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 1.23A 2hyyC-4ueuA:
33.2		 2hyyC-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
ILE A  55
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.18A 2hyyC-4ueuA:
33.2		 2hyyC-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
VAL A  65
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.58A 2hyyC-4ueuA:
33.2		 2hyyC-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
VAL A  65
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.76A 2hyyC-4ueuA:
33.2		 2hyyC-4ueuA:
66.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  48
ALA A  61
VAL A  92
PHE A 110
GLY A 114
LEU A 162
ALA A 172
ASP A 173
 None
6UI  A 700 (-3.3A)
None
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
 0.97A 2hyyC-4usfA:
25.0		 2hyyC-4usfA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  72
GLU A  90
VAL A 104
PHE A 128
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.96A 2hyyC-4wsqA:
23.0		 2hyyC-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  60
ALA A  72
GLU A  90
VAL A 104
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.62A 2hyyC-4wsqA:
23.0		 2hyyC-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ATP  A 601 (-4.4A)
ATP  A 601 ( 3.7A)
ATP  A 601 ( 3.7A)
None
ATP  A 601 (-4.6A)
None
None
 0.81A 2hyyC-4xbrA:
16.6		 2hyyC-4xbrA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 481
ALA A 501
GLU A 520
ILE A 527
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.74A 2hyyC-4xcuA:
31.4		 2hyyC-4xcuA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 VAL B 275
ALA B 288
ILE B 312
VAL B 318
THR B 334
PHE B 336
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.69A 2hyyC-4xeyB:
36.1		 2hyyC-4xeyB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.51A 2hyyC-4xufA:
33.9		 2hyyC-4xufA:
38.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 477
ALA A 488
GLU A 509
THR A 539
GLY A 545
LEU A 595
ALA A 605
 None
4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.65A 2hyyC-4yffA:
25.5		 2hyyC-4yffA:
29.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.72A 2hyyC-5a46A:
30.6		 2hyyC-5a46A:
40.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  44
VAL A  76
GLY A  98
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
 0.50A 2hyyC-5ci7A:
23.2		 2hyyC-5ci7A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 258
ALA A 275
GLU A 290
THR A 325
PHE A 327
GLY A 331
LEU A 386
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.72A 2hyyC-5e8yA:
19.0		 2hyyC-5e8yA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
GLU A 103
VAL A 116
GLY A 138
LEU A 185
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.3A)
None
5RC  A4000 ( 3.9A)
 0.94A 2hyyC-5es1A:
11.0		 2hyyC-5es1A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 VAL A 107
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.81A 2hyyC-5eykA:
17.7		 2hyyC-5eykA:
25.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 607
ALA A 625
GLU A 644
VAL A 658
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.61A 2hyyC-5grnA:
29.6		 2hyyC-5grnA:
36.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A  94
ALA A 105
VAL A 134
THR A 148
GLY A 154
LEU A 215
 None
 0.34A 2hyyC-5gz8A:
19.4		 2hyyC-5gz8A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 VAL A  28
ALA A  41
GLU A  61
VAL A  74
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.60A 2hyyC-5hu3A:
23.4		 2hyyC-5hu3A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
GLU A  61
VAL A  74
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.59A 2hyyC-5j5tA:
21.9		 2hyyC-5j5tA:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 VAL A 897
ALA A 909
GLU A 927
VAL A 940
PHE A 958
GLY A 962
LEU A1016
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
 0.63A 2hyyC-5lpyA:
23.2		 2hyyC-5lpyA:
30.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 VAL A 897
ALA A 909
GLU A 927
VAL A 940
PHE A 958
GLY A 962
LEU A1016
 ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
None
None
ADP  A1200 (-4.1A)
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
 0.69A 2hyyC-5lpzA:
23.2		 2hyyC-5lpzA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 119
ILE A 143
VAL A 153
GLY A 174
LEU A 221
ALA A 231
ASP A 232
 None
 1.20A 2hyyC-5u7qA:
18.6		 2hyyC-5u7qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 119
ILE A 143
VAL A 153
GLY A 175
LEU A 221
ALA A 231
ASP A 232
 None
 1.09A 2hyyC-5u7qA:
18.6		 2hyyC-5u7qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 106
ALA A 119
GLU A 140
VAL A 153
GLY A 175
LEU A 221
ALA A 231
 None
 0.93A 2hyyC-5u7qA:
18.6		 2hyyC-5u7qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 106
ALA A 119
ILE A 143
VAL A 153
GLY A 175
LEU A 221
ALA A 231
 None
 1.00A 2hyyC-5u7qA:
18.6		 2hyyC-5u7qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 7 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
None
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
 0.77A 2hyyC-5vefA:
22.8		 2hyyC-5vefA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 VAL A 694
ALA A 707
GLU A 725
VAL A 738
GLY A 760
LEU A 810
 9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.53A 2hyyC-5vilA:
19.3		 2hyyC-5vilA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		4 LEU A 136
VAL A 112
MET A  11
ILE A  93
 None
 1.16A 2hyyC-1c9eA:
undetectable		 2hyyC-1c9eA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 LEU C 211
VAL C 359
MET C 343
ILE C 380
 None
 1.10A 2hyyC-1d7wC:
undetectable		 2hyyC-1d7wC:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gom ENDO-1,4-BETA-XYLANA
SE

(Thermoascus
aurantiacus) 		PF00331
(Glyco_hydro_10) 		4 LEU A 139
VAL A 107
MET A 108
ILE A 148
 None
 1.13A 2hyyC-1gomA:
undetectable		 2hyyC-1gomA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 248
LYS A 251
VAL A  58
MET A  95
 None
 0.93A 2hyyC-1iovA:
undetectable		 2hyyC-1iovA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LEU A 245
VAL A 323
ILE A 300
MET A  82
 None
 1.14A 2hyyC-1jr1A:
undetectable		 2hyyC-1jr1A:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 239
MET A 240
ILE A 264
 None
 0.45A 2hyyC-1k9aA:
31.3		 2hyyC-1k9aA:
30.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 239
MET A 240
ILE A 264
MET A 269
 None
 0.58A 2hyyC-1k9aA:
31.3		 2hyyC-1k9aA:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		4 LEU A  28
VAL A 137
ILE A  93
MET A  74
 None
 1.17A 2hyyC-1o60A:
undetectable		 2hyyC-1o60A:
18.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
LYS A 290
VAL A 308
MET A 309
ILE A 332
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
 0.53A 2hyyC-1opkA:
35.2		 2hyyC-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
VAL A 308
MET A 309
ILE A 332
MET A 337
 P16  A   2 ( 4.2A)
None
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
None
 0.44A 2hyyC-1opkA:
35.2		 2hyyC-1opkA:
99.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		4 LEU A 189
VAL A 266
ILE A 272
MET A 217
 None
 1.01A 2hyyC-1un9A:
undetectable		 2hyyC-1un9A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		4 LEU A  91
VAL A 378
MET A 379
ILE A 139
 None
 1.10A 2hyyC-1xr4A:
undetectable		 2hyyC-1xr4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.06A 2hyyC-1ycnA:
undetectable		 2hyyC-1ycnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 177
VAL A 290
ILE A 201
MET A 224
 None
 1.12A 2hyyC-1zklA:
undetectable		 2hyyC-1zklA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8j FERROCHELATASE 1

(Bacillus
anthracis) 		PF00762
(Ferrochelatase) 		4 LEU A 135
VAL A 111
MET A  10
ILE A  92
 None
 1.13A 2hyyC-2c8jA:
undetectable		 2hyyC-2c8jA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwe HYPOTHETICAL
TRANSCRIPTION
REGULATOR PROTEIN,
PH1932

(Pyrococcus
horikoshii) 		PF01022
(HTH_5) 		4 LYS A   6
VAL A  16
MET A  17
ILE A   8
 None
 1.01A 2hyyC-2cweA:
undetectable		 2hyyC-2cweA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
LYS X  39
MET X  58
ILE X  80
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
None
 0.53A 2hyyC-2dq7X:
32.5		 2hyyC-2dq7X:
46.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
MET X  58
ILE X  80
MET X  85
 STU  X 902 (-3.8A)
None
None
None
 0.50A 2hyyC-2dq7X:
32.5		 2hyyC-2dq7X:
46.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
LYS A 186
VAL A 204
ILE A 234
 None
 0.78A 2hyyC-2eu9A:
22.0		 2hyyC-2eu9A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.91A 2hyyC-2hckA:
30.4		 2hyyC-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
LYS A 273
VAL A 291
MET A 292
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
 0.61A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 291
MET A 292
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
None
 0.65A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
LYS A 271
VAL A 289
MET A 290
ILE A 313
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
 0.80A 2hyyC-2hz0A:
35.5		 2hyyC-2hz0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 289
MET A 290
ILE A 313
MET A 318
 GIN  A 600 ( 4.6A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
None
 0.38A 2hyyC-2hz0A:
35.5		 2hyyC-2hz0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A 744
VAL A 798
MET A 797
ILE A 751
 None
 1.13A 2hyyC-2i1yA:
undetectable		 2hyyC-2i1yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipp CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU B 181
VAL B 246
ILE B 201
MET B 195
 None
 1.15A 2hyyC-2ippB:
undetectable		 2hyyC-2ippB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		4 LEU G  78
MET G 112
ILE G  66
MET G 302
 None
 1.16A 2hyyC-2nzuG:
undetectable		 2hyyC-2nzuG:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN

(Archaeoglobus
fulgidus) 		PF00437
(T2SSE) 		4 LEU 1 253
VAL 1 373
MET 1 372
ILE 1 264
 None
 0.90A 2hyyC-2oap1:
undetectable		 2hyyC-2oap1:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
LYS A 273
MET A 292
ILE A 314
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
 0.99A 2hyyC-2og8A:
32.6		 2hyyC-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
MET A 292
ILE A 314
MET A 319
 None
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
 0.71A 2hyyC-2og8A:
32.6		 2hyyC-2og8A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 LEU A 276
VAL A 165
MET A 168
ILE A 210
 None
 1.17A 2hyyC-2qagA:
undetectable		 2hyyC-2qagA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 190
VAL A 217
MET A 218
ILE A 197
 None
 1.13A 2hyyC-2vawA:
undetectable		 2hyyC-2vawA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A  15
VAL A 303
MET A 302
ILE A 389
 None
 1.17A 2hyyC-2vqdA:
undetectable		 2hyyC-2vqdA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 653
MET A 674
ILE A 697
MET A 702
 Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
None
 0.50A 2hyyC-2xyuA:
32.7		 2hyyC-2xyuA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1002
VAL A1050
MET A1051
MET A1079
 S91  A   1 ( 4.1A)
None
None
None
 0.68A 2hyyC-2z8cA:
29.6		 2hyyC-2z8cA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 253
LYS A 275
MET A 294
ILE A 317
 None
 0.95A 2hyyC-2zv7A:
26.3		 2hyyC-2zv7A:
46.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 239
MET A 240
ILE A 264
 None
 0.45A 2hyyC-3d7uA:
27.3		 2hyyC-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 239
MET A 240
ILE A 264
MET A 269
 None
 0.58A 2hyyC-3d7uA:
27.3		 2hyyC-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LYS A 665
MET A 686
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.5A)
None
None
 0.72A 2hyyC-3dkoA:
31.5		 2hyyC-3dkoA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
ILE A 127
MET A 132
 STU  A   1 (-3.8A)
STU  A   1 ( 4.2A)
None
None
 0.50A 2hyyC-3fmeA:
17.3		 2hyyC-3fmeA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 4 LEU K 738
MET K 775
ILE K 756
MET K 718
 None
 1.07A 2hyyC-3jblK:
undetectable		 2hyyC-3jblK:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9m CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU A 181
VAL A 246
ILE A 201
MET A 195
 None
 1.10A 2hyyC-3k9mA:
undetectable		 2hyyC-3k9mA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		4 LEU A 130
VAL A 182
MET A 181
ILE A 166
 None
 1.16A 2hyyC-3krvA:
undetectable		 2hyyC-3krvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		4 LEU A 158
VAL A 182
MET A 181
ILE A 166
 None
 1.09A 2hyyC-3krvA:
undetectable		 2hyyC-3krvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 LEU A 375
LYS A 368
ILE A 245
MET A 254
 None
 1.07A 2hyyC-3maxA:
undetectable		 2hyyC-3maxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacteroides
thetaiotaomicron) 		PF08543
(Phos_pyr_kin) 		4 LEU A  40
VAL A 129
MET A 128
ILE A  91
 None
 1.01A 2hyyC-3mbhA:
undetectable		 2hyyC-3mbhA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN

(Paraburkholderia
xenovorans) 		PF13458
(Peripla_BP_6) 		4 VAL A 197
MET A 168
ILE A 221
MET A 267
 None
 0.95A 2hyyC-3n0wA:
undetectable		 2hyyC-3n0wA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  88
LYS A 111
VAL A 133
MET A 134
 JOZ  A 361 (-4.1A)
SO4  A   5 (-2.8A)
None
None
 0.87A 2hyyC-3nuuA:
23.3		 2hyyC-3nuuA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 VAL A  33
MET A  34
ILE A  94
MET A 299
 None
 1.02A 2hyyC-3nwrA:
undetectable		 2hyyC-3nwrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 LEU A  79
MET A 113
ILE A  67
MET A 303
 None
 1.09A 2hyyC-3oqnA:
undetectable		 2hyyC-3oqnA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 LEU A 298
VAL A 407
ILE A 358
MET A 319
 None
 1.05A 2hyyC-3oqqA:
undetectable		 2hyyC-3oqqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 LEU A 175
VAL A  70
MET A  71
ILE A 188
 None
 0.98A 2hyyC-3r75A:
undetectable		 2hyyC-3r75A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 LEU A 390
VAL A  70
MET A  71
ILE A 188
 None
 1.06A 2hyyC-3r75A:
undetectable		 2hyyC-3r75A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE

(Cytophaga
hutchinsonii) 		PF00480
(ROK) 		4 LEU A 114
VAL A 239
MET A 240
ILE A 129
 None
 1.11A 2hyyC-3r8eA:
undetectable		 2hyyC-3r8eA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 345
LYS A 368
VAL A 387
MET A 388
 STU  A   1 (-3.8A)
STU  A   1 (-3.1A)
None
None
 0.88A 2hyyC-3s95A:
24.5		 2hyyC-3s95A:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8k UNCHARACTERIZED
PROTEIN

(Leptotrichia
buccalis) 		no annotation 4 LEU A 132
LYS A  95
MET A  56
ILE A  96
 None
 1.03A 2hyyC-3t8kA:
undetectable		 2hyyC-3t8kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
ILE A 127
MET A 132
 None
ANK  A 401 (-2.4A)
None
None
 0.82A 2hyyC-3vn9A:
22.2		 2hyyC-3vn9A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		4 LEU A 497
VAL A 974
MET A 975
ILE A 410
 None
 1.08A 2hyyC-3w9iA:
undetectable		 2hyyC-3w9iA:
12.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
LYS A 655
MET A 676
MET A 704
 None
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
None
 0.95A 2hyyC-4ckrA:
32.2		 2hyyC-4ckrA:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF06187
(DUF993) 		4 LEU A 200
VAL A 242
MET A 243
ILE A 232
 None
 1.04A 2hyyC-4dnhA:
undetectable		 2hyyC-4dnhA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 LEU A 268
VAL A  23
ILE A  11
MET A 414
 None
 1.14A 2hyyC-4dshA:
undetectable		 2hyyC-4dshA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 187
VAL A 214
MET A 215
ILE A 194
 None
 1.14A 2hyyC-4e6eA:
undetectable		 2hyyC-4e6eA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		4 LEU A  36
VAL A  99
ILE A  74
MET A   1
 None
 1.17A 2hyyC-4eysA:
undetectable		 2hyyC-4eysA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 377
LYS A 402
VAL A 423
MET A 424
 0SB  A 701 ( 3.9A)
0SB  A 701 ( 4.8A)
None
None
 0.76A 2hyyC-4f4pA:
30.7		 2hyyC-4f4pA:
40.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		4 LEU A 131
VAL A 218
MET A 219
ILE A  87
 None
 1.15A 2hyyC-4jzxA:
undetectable		 2hyyC-4jzxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  33
LYS A  56
MET A  74
ILE A  97
 GOL  A 404 ( 3.6A)
GOL  A 403 ( 4.6A)
None
None
 1.00A 2hyyC-4lg4A:
17.8		 2hyyC-4lg4A:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
LYS A 295
VAL A 313
MET A 314
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
 0.84A 2hyyC-4lggA:
30.2		 2hyyC-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 313
MET A 314
ILE A 336
MET A 341
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
None
 0.85A 2hyyC-4lggA:
30.2		 2hyyC-4lggA:
47.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 LEU A  53
LYS A  76
MET A  98
MET A 133
 046  A 401 ( 3.9A)
046  A 401 ( 4.7A)
046  A 401 (-3.5A)
None
 0.91A 2hyyC-4o2zA:
22.1		 2hyyC-4o2zA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 LEU A 281
VAL A 237
ILE A 244
MET A 106
 None
 1.04A 2hyyC-4uoeA:
undetectable		 2hyyC-4uoeA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
LYS A  74
MET A  94
ILE A 124
 KSA  A 405 ( 4.0A)
None
None
None
 0.67A 2hyyC-4wsqA:
23.0		 2hyyC-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 LYS A 294
VAL A 288
ILE A 292
MET A 179
 None
 0.97A 2hyyC-4x8rA:
undetectable		 2hyyC-4x8rA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 473
LYS A 503
VAL A 523
MET A 524
 40M  A1002 ( 4.6A)
40M  A1002 (-4.0A)
None
40M  A1002 (-3.8A)
 0.80A 2hyyC-4xcuA:
31.4		 2hyyC-4xcuA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 LEU B 267
LYS B 290
VAL B 308
MET B 309
ILE B 332
 1N1  B 601 (-3.7A)
1N1  B 601 (-4.6A)
None
1N1  B 601 (-3.7A)
1N1  B 601 (-4.1A)
 0.88A 2hyyC-4xeyB:
36.1		 2hyyC-4xeyB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 LEU B 267
VAL B 308
MET B 309
ILE B 332
MET B 337
 1N1  B 601 (-3.7A)
None
1N1  B 601 (-3.7A)
1N1  B 601 (-4.1A)
None
 0.61A 2hyyC-4xeyB:
36.1		 2hyyC-4xeyB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 4 LEU E 293
VAL E 335
ILE E 331
MET E 259
 None
 1.16A 2hyyC-4xmmE:
undetectable		 2hyyC-4xmmE:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		4 LEU B 136
VAL B 223
MET B 224
ILE B  92
 None
 1.12A 2hyyC-5ahuB:
undetectable		 2hyyC-5ahuB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A 127
VAL A 200
MET A 201
ILE A  80
 None
 0.99A 2hyyC-5e8kA:
undetectable		 2hyyC-5e8kA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 LEU A  62
VAL A 464
MET A 463
ILE A 491
 None
 1.05A 2hyyC-5ev7A:
undetectable		 2hyyC-5ev7A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		4 VAL A 482
MET A 483
ILE A 536
MET A 522
 None
 1.15A 2hyyC-5fgnA:
undetectable		 2hyyC-5fgnA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
LYS A 627
MET A 648
ILE A 672
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
 0.81A 2hyyC-5grnA:
29.6		 2hyyC-5grnA:
36.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 LEU A  97
MET A 495
ILE A 708
MET A  93
 None
 1.06A 2hyyC-5h53A:
undetectable		 2hyyC-5h53A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  57
LYS A  79
MET A  99
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 ( 4.8A)
None
None
 0.48A 2hyyC-5i3oA:
22.6		 2hyyC-5i3oA:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 718
LYS A 745
VAL A 765
MET A 766
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.1A)
 0.55A 2hyyC-5j9zA:
30.4		 2hyyC-5j9zA:
36.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 718
VAL A 765
MET A 766
MET A 793
 6HJ  A1101 ( 4.6A)
None
6HJ  A1101 ( 4.1A)
None
 0.94A 2hyyC-5j9zA:
30.4		 2hyyC-5j9zA:
36.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Rhinovirus C) 		PF00073
(Rhv) 		4 LEU B  25
VAL A 121
ILE A 130
MET A 204
 None
 1.15A 2hyyC-5k0uB:
undetectable		 2hyyC-5k0uB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 LEU A 511
VAL A  57
MET A  58
ILE A  36
 None
 1.04A 2hyyC-5kgnA:
undetectable		 2hyyC-5kgnA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 665
MET A 686
ILE A 709
MET A 714
 None
6P6  A1001 ( 4.2A)
6P6  A1001 ( 4.5A)
None
 0.69A 2hyyC-5l6oA:
33.3		 2hyyC-5l6oA:
38.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 LEU A 377
VAL A 525
MET A 509
ILE A 546
 None
 1.17A 2hyyC-5mfaA:
undetectable		 2hyyC-5mfaA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 LEU A 114
VAL A 369
ILE A  36
MET A 153
 None
 1.09A 2hyyC-5x2qA:
undetectable		 2hyyC-5x2qA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zm4 DIOXYGENASE ANDA

(Aspergillus
stellatus) 		no annotation 4 VAL A  54
MET A  55
ILE A 225
MET A  73
 None
None
None
9FU  A 303 ( 4.5A)
 1.17A 2hyyC-5zm4A:
undetectable		 2hyyC-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 LEU A 377
VAL A 525
MET A 509
ILE A 546
 None
 1.13A 2hyyC-6azpA:
undetectable		 2hyyC-6azpA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 4 LEU A 150
VAL A  83
ILE A 116
MET A 245
 None
 1.16A 2hyyC-6b5fA:
undetectable		 2hyyC-6b5fA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 4 LEU E1519
VAL E1550
ILE E1535
MET E1524
 None
 1.17A 2hyyC-6c3pE:
undetectable		 2hyyC-6c3pE:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE

(Proteus
mirabilis) 		no annotation 4 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 1.03A 2hyyC-6cn0A:
undetectable		 2hyyC-6cn0A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 4 LEU A 197
LYS A 219
ILE A 262
MET A 267
 FKY  A9001 (-4.1A)
None
None
None
 1.03A 2hyyC-6cz4A:
22.2		 2hyyC-6cz4A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 LEU A1084
LYS A 787
VAL A 925
ILE A 800
 None
 1.00A 2hyyC-6en4A:
undetectable		 2hyyC-6en4A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 LEU A 169
LYS A 193
VAL A 211
ILE A 241
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.0A)
None
None
 0.65A 2hyyC-6fylA:
22.2		 2hyyC-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.66A 2hyyC-6fyoA:
21.9		 2hyyC-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.71A 2hyyC-6fyvA:
22.1		 2hyyC-6fyvA:
undetectable