SIMILAR PATTERNS OF AMINO ACIDS FOR 2HYY_B_STIB600_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 248
LYS A 251
VAL A  58
MET A  95
 None
 0.98A 2hyyB-1iovA:
undetectable		 2hyyB-1iovA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsd HAEMAGGLUTININ (HA1
CHAIN)

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 144
VAL A 226
VAL A 194
ILE A 116
 None
 1.03A 2hyyB-1jsdA:
undetectable		 2hyyB-1jsdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Haemophilus
influenzae) 		PF08282
(Hydrolase_3) 		4 LEU A 156
VAL A  15
VAL A  54
ILE A 105
 None
 1.17A 2hyyB-1k1eA:
undetectable		 2hyyB-1k1eA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 LEU A 370
VAL A 466
ILE A 269
MET A 396
 None
 1.24A 2hyyB-1k6mA:
undetectable		 2hyyB-1k6mA:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.63A 2hyyB-1k9aA:
31.0		 2hyyB-1k9aA:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no5 HYPOTHETICAL PROTEIN
HI0073

(Haemophilus
influenzae) 		PF01909
(NTP_transf_2) 		4 LEU A  24
VAL A  37
VAL A  78
ILE A 101
 None
 1.23A 2hyyB-1no5A:
undetectable		 2hyyB-1no5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  70
LYS A  93
VAL A 118
ILE A 136
 STU  A 401 (-3.9A)
STU  A 401 ( 4.5A)
None
None
 0.50A 2hyyB-1nxkA:
19.3		 2hyyB-1nxkA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
LYS A 290
VAL A 308
VAL A 318
ILE A 332
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
 0.54A 2hyyB-1opkA:
34.7		 2hyyB-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 267
VAL A 308
ILE A 332
MET A 337
 P16  A   2 ( 4.2A)
None
P16  A   2 (-4.1A)
None
 0.44A 2hyyB-1opkA:
34.7		 2hyyB-1opkA:
99.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryo SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 LEU A 134
VAL A  67
VAL A 246
ILE A 323
 None
 1.14A 2hyyB-1ryoA:
undetectable		 2hyyB-1ryoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni) 		PF13580
(SIS_2) 		4 LEU A  64
VAL A 160
VAL A  31
ILE A 176
 None
 1.25A 2hyyB-1tk9A:
undetectable		 2hyyB-1tk9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.02A 2hyyB-1ycnA:
undetectable		 2hyyB-1ycnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		4 LEU A  19
VAL A  40
VAL A   8
ILE A 125
 None
 0.94A 2hyyB-2akoA:
undetectable		 2hyyB-2akoA:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
LYS X  39
VAL X  67
ILE X  80
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
None
 0.61A 2hyyB-2dq7X:
32.5		 2hyyB-2dq7X:
46.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
LYS A 186
VAL A 204
ILE A 234
 None
 0.63A 2hyyB-2eu9A:
22.0		 2hyyB-2eu9A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
VAL A 204
VAL A 220
ILE A 234
 None
 0.51A 2hyyB-2eu9A:
22.0		 2hyyB-2eu9A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
None
 0.92A 2hyyB-2hckA:
30.3		 2hyyB-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.64A 2hyyB-2hk5A:
27.5		 2hyyB-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.9A)
None
 0.74A 2hyyB-2hk5A:
27.5		 2hyyB-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 248
LYS A 271
VAL A 289
ILE A 313
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.8A)
 0.74A 2hyyB-2hz0A:
35.3		 2hyyB-2hz0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 289
VAL A 299
ILE A 313
MET A 318
 GIN  A 600 ( 4.6A)
None
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
 0.38A 2hyyB-2hz0A:
35.3		 2hyyB-2hz0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A  73
VAL A 121
VAL A 114
ILE A 105
 None
 1.02A 2hyyB-2i80A:
undetectable		 2hyyB-2i80A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipp CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU B 181
VAL B 246
ILE B 201
MET B 195
 None
 1.19A 2hyyB-2ippB:
undetectable		 2hyyB-2ippB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.14A 2hyyB-2iyoA:
undetectable		 2hyyB-2iyoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnl C-X-C CHEMOKINE
RECEPTOR TYPE 1

(Homo sapiens) 		PF00001
(7tm_1) 		4 LEU A  37
VAL A 261
VAL A 272
ILE A 283
 None
 0.74A 2hyyB-2lnlA:
undetectable		 2hyyB-2lnlA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 301
ILE A 314
MET A 319
 None
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
 0.67A 2hyyB-2og8A:
32.6		 2hyyB-2og8A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU X  70
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
F10  X 401 (-4.3A)
None
None
 0.72A 2hyyB-2p3gX:
17.6		 2hyyB-2p3gX:
24.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 253
LYS A 275
VAL A 303
ILE A 317
 None
 0.92A 2hyyB-2zv7A:
31.9		 2hyyB-2zv7A:
46.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		4 LEU A  60
VAL A  47
VAL A  72
ILE A  16
 None
 0.98A 2hyyB-3d0cA:
undetectable		 2hyyB-3d0cA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.63A 2hyyB-3d7uA:
31.8		 2hyyB-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.66A 2hyyB-3dkoA:
31.4		 2hyyB-3dkoA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A  94
VAL A  61
VAL A  76
ILE A  64
 None
 0.97A 2hyyB-3e82A:
undetectable		 2hyyB-3e82A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
ILE A 127
MET A 132
 STU  A   1 (-3.8A)
STU  A   1 ( 4.2A)
None
None
 0.52A 2hyyB-3fmeA:
17.6		 2hyyB-3fmeA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
VAL A 113
ILE A 127
 STU  A   1 (-3.8A)
STU  A   1 ( 4.2A)
None
None
 0.52A 2hyyB-3fmeA:
17.6		 2hyyB-3fmeA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g40 NA-K-CL
COTRANSPORTER

(Methanosarcina
acetivorans) 		no annotation 4 LEU A 760
VAL A 704
VAL A 700
ILE A 635
 None
 1.00A 2hyyB-3g40A:
undetectable		 2hyyB-3g40A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggg PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		no annotation 4 LEU D 139
LYS D 110
VAL D  36
ILE D  84
 None
 1.09A 2hyyB-3gggD:
undetectable		 2hyyB-3gggD:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9m CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU A 181
VAL A 246
ILE A 201
MET A 195
 None
 1.14A 2hyyB-3k9mA:
undetectable		 2hyyB-3k9mA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE

(Staphylococcus
saprophyticus) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LEU A 127
VAL A 163
VAL A 158
ILE A 137
 None
 1.11A 2hyyB-3l8mA:
undetectable		 2hyyB-3l8mA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 LEU A 375
LYS A 368
ILE A 245
MET A 254
 None
 1.05A 2hyyB-3maxA:
undetectable		 2hyyB-3maxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 246
VAL A 362
VAL A 268
ILE A 325
 None
 1.07A 2hyyB-3mruA:
undetectable		 2hyyB-3mruA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 LEU B 587
VAL B 594
VAL B 711
ILE B 591
 None
 1.11A 2hyyB-3o8oB:
undetectable		 2hyyB-3o8oB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtd PMBA PROTEIN

(Pseudomonas
aeruginosa) 		PF01523
(PmbA_TldD) 		4 LEU A 300
VAL A 424
VAL A 253
ILE A 428
 None
 1.00A 2hyyB-3qtdA:
undetectable		 2hyyB-3qtdA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  50
LYS A  73
VAL A  98
ILE A 116
 I85  A 350 (-3.7A)
I85  A 350 (-2.8A)
None
None
 0.72A 2hyyB-3sheA:
18.5		 2hyyB-3sheA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU C1186
VAL C1023
VAL C1090
ILE C1061
 None
 1.24A 2hyyB-3sr6C:
undetectable		 2hyyB-3sr6C:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4x OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Bacillus
anthracis) 		PF00106
(adh_short) 		4 LEU A   5
VAL A  44
VAL A  12
ILE A  51
 None
 1.15A 2hyyB-3t4xA:
undetectable		 2hyyB-3t4xA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		4 LEU A 111
VAL A 134
VAL A 126
ILE A 150
 None
 1.10A 2hyyB-3u02A:
undetectable		 2hyyB-3u02A:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 544
LYS A 572
VAL A 601
MET A 620
 0F4  A 902 ( 4.2A)
0F4  A 902 (-4.0A)
None
None
 0.84A 2hyyB-3v5qA:
29.2		 2hyyB-3v5qA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 LEU A 427
VAL A 467
ILE A 494
MET A  93
 None
 1.15A 2hyyB-3vssA:
undetectable		 2hyyB-3vssA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		4 LEU A 141
VAL A 187
ILE A  62
MET A 197
 None
 1.24A 2hyyB-3wazA:
undetectable		 2hyyB-3wazA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  75
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.67A 2hyyB-3wigA:
22.5		 2hyyB-3wigA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)

(Trypanosoma
brucei) 		PF00025
(Arf) 		4 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 0.90A 2hyyB-4basA:
undetectable		 2hyyB-4basA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 LEU A  88
VAL A 445
VAL A 405
ILE A 415
 None
 1.09A 2hyyB-4ckbA:
undetectable		 2hyyB-4ckbA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz2 RAS-RELATED PROTEIN
RAB-32

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A  67
VAL A  60
VAL A  28
ILE A  42
 None
 1.16A 2hyyB-4cz2A:
undetectable		 2hyyB-4cz2A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei0 UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF14725
(DUF4466) 		4 LEU A 190
VAL A 324
VAL A 328
ILE A 198
 None
 1.24A 2hyyB-4ei0A:
undetectable		 2hyyB-4ei0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.7A)
BX7  A 401 ( 4.0A)
None
None
 0.73A 2hyyB-4eutA:
11.4		 2hyyB-4eutA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.5A)
None
None
 0.70A 2hyyB-4euuA:
21.6		 2hyyB-4euuA:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 377
LYS A 402
VAL A 423
VAL A 433
 0SB  A 701 ( 3.9A)
0SB  A 701 ( 4.8A)
None
None
 0.82A 2hyyB-4f4pA:
30.7		 2hyyB-4f4pA:
40.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 650
VAL A 636
VAL A 741
ILE A 642
 LEU  A 650 ( 0.6A)
VAL  A 636 ( 0.5A)
VAL  A 741 ( 0.5A)
ILE  A 642 ( 0.6A)
 0.84A 2hyyB-4flxA:
undetectable		 2hyyB-4flxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 598
LYS A 621
VAL A 651
ILE A 885
 924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
 0.54A 2hyyB-4g34A:
20.6		 2hyyB-4g34A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 422
VAL A 366
VAL A 453
ILE A 416
 None
C  D   8 ( 3.9A)
None
G  D   9 ( 4.4A)
 1.15A 2hyyB-4gl2A:
undetectable		 2hyyB-4gl2A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon)
PF08646
(Rep_fac-A_C)
PF16900
(REPA_OB_2) 		4 LEU C 485
VAL C 473
VAL C 477
ILE C 600
 None
 0.89A 2hyyB-4gnxC:
undetectable		 2hyyB-4gnxC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		4 LEU A 169
VAL A 294
VAL A 238
ILE A 192
 None
 0.90A 2hyyB-4hjwA:
undetectable		 2hyyB-4hjwA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
 0.69A 2hyyB-4k11A:
30.6		 2hyyB-4k11A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 313
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
 0.77A 2hyyB-4lggA:
29.9		 2hyyB-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.65A 2hyyB-4lggA:
29.9		 2hyyB-4lggA:
47.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oky RESTRICTION
ENDONUCLEASE PVURTS1
I

(Proteus
vulgaris) 		no annotation 4 LEU C   8
LYS C  13
VAL C  28
ILE C  14
 None
 0.88A 2hyyB-4okyC:
undetectable		 2hyyB-4okyC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE

(Mycobacterium
tuberculosis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A  41
VAL A 118
VAL A 122
ILE A  70
 None
None
NAP  A 301 (-4.3A)
None
 1.09A 2hyyB-4ol9A:
undetectable		 2hyyB-4ol9A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 LEU A  70
VAL A 163
VAL A 188
ILE A 183
 None
 1.13A 2hyyB-4r5zA:
undetectable		 2hyyB-4r5zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1

(Homo sapiens) 		PF05609
(LAP1C) 		4 LEU A 536
VAL A 506
VAL A 478
ILE A 409
 None
 1.07A 2hyyB-4tvsA:
undetectable		 2hyyB-4tvsA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
LYS A  37
VAL A  65
ILE A  79
 ACP  A1264 ( 4.5A)
None
None
None
 0.80A 2hyyB-4ueuA:
33.0		 2hyyB-4ueuA:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
VAL A  65
ILE A  79
MET A  84
 ACP  A1264 ( 4.5A)
None
None
None
 0.68A 2hyyB-4ueuA:
33.0		 2hyyB-4ueuA:
66.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0k ARF-LIKE SMALL
GTPASE

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		4 LEU A 163
VAL A  20
VAL A  93
ILE A  34
 GDP  A 700 (-4.4A)
None
None
None
 0.85A 2hyyB-4v0kA:
undetectable		 2hyyB-4v0kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
LYS A  74
VAL A 104
ILE A 124
 KSA  A 405 ( 4.0A)
None
None
None
 0.58A 2hyyB-4wsqA:
23.0		 2hyyB-4wsqA:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LEU B 267
LYS B 290
VAL B 318
ILE B 332
 1N1  B 601 (-3.7A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
 0.91A 2hyyB-4xeyB:
35.8		 2hyyB-4xeyB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LEU B 267
VAL B 308
ILE B 332
MET B 337
 1N1  B 601 (-3.7A)
None
1N1  B 601 (-4.1A)
None
 0.68A 2hyyB-4xeyB:
35.8		 2hyyB-4xeyB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LEU B 267
VAL B 308
VAL B 318
ILE B 332
 1N1  B 601 (-3.7A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
 0.59A 2hyyB-4xeyB:
35.8		 2hyyB-4xeyB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 LEU A 242
VAL A 274
VAL A 284
ILE A 259
 None
 1.19A 2hyyB-4xyiA:
undetectable		 2hyyB-4xyiA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		4 LEU A  92
VAL A  12
VAL A 109
ILE A 128
 None
 1.22A 2hyyB-4zhtA:
undetectable		 2hyyB-4zhtA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 651
VAL A 637
VAL A 742
ILE A 643
 None
 0.98A 2hyyB-5h12A:
undetectable		 2hyyB-5h12A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		4 LEU A 104
VAL A 338
VAL A 193
ILE A  62
 None
 1.16A 2hyyB-5hgcA:
undetectable		 2hyyB-5hgcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  57
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 ( 4.8A)
None
None
 0.43A 2hyyB-5i3oA:
9.9		 2hyyB-5i3oA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lph CENTROSOMAL PROTEIN
OF 104 KDA

(Homo sapiens) 		no annotation 4 LEU A 598
VAL A 615
VAL A 572
ILE A 632
 None
 1.13A 2hyyB-5lphA:
undetectable		 2hyyB-5lphA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA

(Methanothermococcus
thermolithotrophicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 LEU B  93
VAL B  48
ILE B  85
MET B 131
 None
 1.07A 2hyyB-5n1qB:
undetectable		 2hyyB-5n1qB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA

(Methanothermococcus
thermolithotrophicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 VAL B  79
VAL B  48
ILE B 142
MET B 131
 None
 1.25A 2hyyB-5n1qB:
undetectable		 2hyyB-5n1qB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  17
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.72A 2hyyB-5u94A:
24.1		 2hyyB-5u94A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Clostridium
perfringens) 		PF00478
(IMPDH) 		4 LEU A 217
VAL A 295
ILE A 272
MET A  61
 None
 1.25A 2hyyB-5uzeA:
undetectable		 2hyyB-5uzeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Burkholderia
ambifaria) 		PF12697
(Abhydrolase_6) 		4 LEU A 227
VAL A 264
VAL A 252
ILE A 243
 None
 1.11A 2hyyB-5w15A:
undetectable		 2hyyB-5w15A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)

(Helicobacter
pylori) 		PF02154
(FliM) 		4 LEU E 132
VAL E 202
VAL E 161
ILE E 205
 None
 1.18A 2hyyB-5x0zE:
undetectable		 2hyyB-5x0zE:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
BETA-CATENIN-LIKE
PROTEIN HMP-2

(Caenorhabditis
elegans) 		PF01044
(Vinculin)
no annotation 		4 LEU A 193
VAL A 130
VAL B  49
ILE A 135
 None
 0.91A 2hyyB-5xa5A:
undetectable		 2hyyB-5xa5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		no annotation 4 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.11A 2hyyB-5zzkA:
undetectable		 2hyyB-5zzkA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 4 LEU A 150
VAL A  83
ILE A 116
MET A 245
 None
 1.25A 2hyyB-6b5fA:
undetectable		 2hyyB-6b5fA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT

(Pyrococcus
furiosus) 		no annotation 4 LEU M 315
VAL M 276
VAL M 248
MET M 152
 None
 1.19A 2hyyB-6cfwM:
undetectable		 2hyyB-6cfwM:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 869
VAL A 558
ILE A 883
MET A 921
 None
 1.21A 2hyyB-6eojA:
undetectable		 2hyyB-6eojA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 4 LEU A 644
VAL A 578
VAL A 662
ILE A 623
 None
 1.10A 2hyyB-6fq3A:
undetectable		 2hyyB-6fq3A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 LEU A 169
LYS A 193
VAL A 211
ILE A 241
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.0A)
None
None
 0.54A 2hyyB-6fylA:
22.1		 2hyyB-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 LEU A 169
VAL A 211
VAL A 227
ILE A 241
 3NG  A 501 (-3.9A)
None
None
None
 0.69A 2hyyB-6fylA:
22.1		 2hyyB-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.63A 2hyyB-6fyoA:
21.9		 2hyyB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
None
None
 0.75A 2hyyB-6fyoA:
21.9		 2hyyB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.64A 2hyyB-6fyvA:
22.0		 2hyyB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 3NG  A 501 (-3.9A)
None
None
None
 0.72A 2hyyB-6fyvA:
22.0		 2hyyB-6fyvA:
undetectable