SIMILAR PATTERNS OF AMINO ACIDS FOR 2HYY_A_STIA600_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		4 LEU A 345
VAL A 136
VAL A 128
ILE A 215
 None
 0.94A 2hyyA-1aj8A:
undetectable		 2hyyA-1aj8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 LEU A  94
VAL A 108
ILE A  83
ARG A   7
 None
 0.98A 2hyyA-1g8xA:
undetectable		 2hyyA-1g8xA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 LEU A 135
VAL A  34
VAL A 104
ARG A 122
 None
 1.03A 2hyyA-1hplA:
undetectable		 2hyyA-1hplA:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 408
LYS A 430
VAL A 458
ILE A 472
 None
 0.88A 2hyyA-1k2pA:
29.4		 2hyyA-1k2pA:
45.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LYS A 222
VAL A 239
VAL A 249
ILE A 264
ARG A 313
 None
 1.03A 2hyyA-1k9aA:
30.9		 2hyyA-1k9aA:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 LEU A 327
VAL A 347
VAL A 284
ILE A 317
 None
 0.98A 2hyyA-1ko0A:
undetectable		 2hyyA-1ko0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 VAL A 479
VAL A 358
ILE A 353
ARG A 459
 None
 0.98A 2hyyA-1lw3A:
undetectable		 2hyyA-1lw3A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  70
LYS A  93
VAL A 118
ILE A 136
ARG A 185
 STU  A 401 (-3.9A)
STU  A 401 ( 4.5A)
None
None
None
 0.90A 2hyyA-1nxkA:
19.1		 2hyyA-1nxkA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
LYS A 290
VAL A 308
VAL A 318
ILE A 332
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
 0.59A 2hyyA-1opkA:
34.9		 2hyyA-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LYS A 290
VAL A 308
VAL A 318
ILE A 332
ARG A 381
 P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
 1.01A 2hyyA-1opkA:
34.9		 2hyyA-1opkA:
99.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		4 LEU A 108
VAL A 500
VAL A  85
ILE A 505
 None
 0.96A 2hyyA-1q3sA:
undetectable		 2hyyA-1q3sA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
LYS A 623
VAL A 643
ARG A 791
 STI  A   3 ( 3.8A)
STI  A   3 (-3.7A)
None
None
 1.01A 2hyyA-1t46A:
34.4		 2hyyA-1t46A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
VAL A 643
VAL A 654
ARG A 791
 STI  A   3 ( 3.8A)
None
STI  A   3 (-4.3A)
None
 0.61A 2hyyA-1t46A:
34.4		 2hyyA-1t46A:
37.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vaj HYPOTHETICAL PROTEIN
PH0010

(Pyrococcus
horikoshii) 		PF01871
(AMMECR1) 		4 LYS A 203
VAL A  14
ILE A 190
ARG A  53
 None
 0.88A 2hyyA-1vajA:
undetectable		 2hyyA-1vajA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 LEU A 725
VAL A 738
VAL A 794
ILE A 771
 None
 0.89A 2hyyA-1vrqA:
undetectable		 2hyyA-1vrqA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 605
LYS A 628
VAL A 656
ILE A 786
 None
None
GOL  A 998 (-4.9A)
None
 0.82A 2hyyA-1zy4A:
20.3		 2hyyA-1zy4A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		4 LEU A  19
VAL A  40
VAL A   8
ILE A 125
 None
 0.98A 2hyyA-2akoA:
undetectable		 2hyyA-2akoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d89 EHBP1 PROTEIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU A  54
VAL A 101
ILE A 108
ARG A  38
 None
 0.99A 2hyyA-2d89A:
undetectable		 2hyyA-2d89A:
16.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
LYS X  39
VAL X  67
ILE X  80
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
None
 0.63A 2hyyA-2dq7X:
32.2		 2hyyA-2dq7X:
46.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
VAL X  67
ILE X  80
ARG X 129
 STU  X 902 (-3.8A)
None
None
PTR  X 160 ( 3.4A)
 0.83A 2hyyA-2dq7X:
32.2		 2hyyA-2dq7X:
46.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A  56
VAL A 199
VAL A 231
ILE A 183
ARG A 214
 None
 1.49A 2hyyA-2dsjA:
undetectable		 2hyyA-2dsjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
LYS A 186
VAL A 204
ILE A 234
 None
 0.79A 2hyyA-2eu9A:
22.1		 2hyyA-2eu9A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
VAL A 204
VAL A 220
ILE A 234
 None
 0.60A 2hyyA-2eu9A:
22.1		 2hyyA-2eu9A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		4 LEU A 726
VAL A 739
VAL A 795
ILE A 772
 None
 0.91A 2hyyA-2gahA:
undetectable		 2hyyA-2gahA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR

(Streptococcus
pneumoniae) 		PF04198
(Sugar-bind) 		4 LEU A  77
VAL A 239
VAL A 311
ILE A 210
 None
 0.91A 2hyyA-2gnpA:
undetectable		 2hyyA-2gnpA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.93A 2hyyA-2h8hA:
30.9		 2hyyA-2h8hA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 QUE  A   1 (-3.9A)
None
None
None
 0.90A 2hyyA-2hckA:
30.1		 2hyyA-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.80A 2hyyA-2hk5A:
27.6		 2hyyA-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
LYS A 271
VAL A 289
ILE A 313
ARG A 362
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.8A)
None
 1.33A 2hyyA-2hz0A:
35.1		 2hyyA-2hz0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 289
VAL A 299
ILE A 313
ARG A 362
 GIN  A 600 ( 4.6A)
None
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
 0.97A 2hyyA-2hz0A:
35.1		 2hyyA-2hz0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 348
LYS A 371
VAL A 393
ARG A 465
 PDS  A 901 (-3.9A)
PDS  A 901 ( 4.5A)
None
TPO  A 500 ( 2.9A)
 0.84A 2hyyA-2i0eA:
13.2		 2hyyA-2i0eA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A  73
VAL A 121
VAL A 114
ILE A 105
 None
 1.02A 2hyyA-2i80A:
undetectable		 2hyyA-2i80A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 LYS A 454
VAL A 484
ILE A 497
ARG A 545
 4ST  A1687 (-3.4A)
None
None
None
 0.55A 2hyyA-2j0jA:
32.4		 2hyyA-2j0jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 VAL A 252
VAL A 152
ILE A 230
ARG A 164
 None
 0.94A 2hyyA-2j1qA:
undetectable		 2hyyA-2j1qA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 LEU A 412
VAL A 372
VAL A 376
ILE A 207
 None
 0.96A 2hyyA-2mbgA:
undetectable		 2hyyA-2mbgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n76 DE NOVO DESIGNED
PROTEIN LFR1

(synthetic
construct) 		no annotation 4 LEU A  82
VAL A  59
VAL A   8
ILE A  26
 None
 0.91A 2hyyA-2n76A:
undetectable		 2hyyA-2n76A:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 301
ILE A 314
ARG A 363
 None
None
1N8  A 501 ( 4.6A)
None
 0.68A 2hyyA-2og8A:
32.5		 2hyyA-2og8A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU X  70
LYS X  93
VAL X 118
ILE X 136
ARG X 185
 F10  X 401 (-3.9A)
F10  X 401 (-4.3A)
None
None
None
 0.98A 2hyyA-2p3gX:
17.5		 2hyyA-2p3gX:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 650
VAL A 636
VAL A 741
ILE A 642
 None
 0.96A 2hyyA-2vwkA:
undetectable		 2hyyA-2vwkA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe SYNTAXIN1
UNC18

(Monosiga
brevicollis) 		PF00804
(Syntaxin)
PF00995
(Sec1)
PF05739
(SNARE) 		4 VAL A  54
VAL B 129
ILE B 135
ARG B 249
 None
 1.02A 2hyyA-2xheA:
undetectable		 2hyyA-2xheA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am6 RHODOPSIN-2

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		4 LEU A 209
VAL A 196
VAL A 184
ILE A 201
 None
 0.97A 2hyyA-3am6A:
undetectable		 2hyyA-3am6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 303
VAL A 246
ILE A 224
ARG A 316
 None
 0.97A 2hyyA-3aoeA:
undetectable		 2hyyA-3aoeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN-TYPE

(Toxoplasma
gondii) 		PF00160
(Pro_isomerase) 		4 LEU A  64
VAL A 145
ILE A  57
ARG A  10
 SO4  A 205 (-4.3A)
None
None
None
 0.87A 2hyyA-3bo7A:
undetectable		 2hyyA-3bo7A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		4 LEU A  60
VAL A  47
VAL A  72
ILE A  16
 None
 0.94A 2hyyA-3d0cA:
undetectable		 2hyyA-3d0cA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 222
VAL A 239
VAL A 249
ILE A 264
ARG A 313
 None
 1.03A 2hyyA-3d7uA:
31.9		 2hyyA-3d7uA:
44.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5

(Schizosaccharomyces
pombe) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 VAL F  53
VAL G 145
ILE G 111
ARG F  13
 None
 1.03A 2hyyA-3dwlF:
undetectable		 2hyyA-3dwlF:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4

(Rattus
norvegicus) 		PF13848
(Thioredoxin_6) 		4 VAL A 413
VAL A 472
ILE A 450
ARG A 497
 None
 1.00A 2hyyA-3ec3A:
undetectable		 2hyyA-3ec3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eea GAF DOMAIN/HD DOMAIN
PROTEIN

(Geobacter
sulfurreducens) 		PF13492
(GAF_3) 		4 LEU A  67
VAL A  29
VAL A 109
ILE A  34
 PG6  A 163 ( 4.9A)
None
None
None
 1.00A 2hyyA-3eeaA:
undetectable		 2hyyA-3eeaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
VAL A 113
ILE A 127
 STU  A   1 (-3.8A)
STU  A   1 ( 4.2A)
None
None
 0.46A 2hyyA-3fmeA:
17.7		 2hyyA-3fmeA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 431
VAL A 487
ILE A 500
ARG A 548
 AGS  A 999 ( 4.4A)
None
None
None
 0.96A 2hyyA-3fzpA:
31.8		 2hyyA-3fzpA:
41.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g40 NA-K-CL
COTRANSPORTER

(Methanosarcina
acetivorans) 		no annotation 4 LEU A 760
VAL A 704
VAL A 700
ILE A 635
 None
 0.96A 2hyyA-3g40A:
undetectable		 2hyyA-3g40A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg9 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
OXIDOREDUCTASE
PROTEIN

(Ralstonia
solanacearum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 167
VAL A 257
ILE A 174
ARG A 249
 None
 1.00A 2hyyA-3gg9A:
undetectable		 2hyyA-3gg9A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h04 UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		4 LEU A  16
VAL A  73
ILE A  79
ARG A 180
 None
 1.01A 2hyyA-3h04A:
undetectable		 2hyyA-3h04A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN

(Desulfovibrio
vulgaris) 		PF00857
(Isochorismatase) 		4 LEU A  22
VAL A 131
ILE A  39
ARG A 141
 None
 0.92A 2hyyA-3hu5A:
undetectable		 2hyyA-3hu5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 LEU B1079
VAL B 989
VAL B1146
ILE B 994
 None
 0.99A 2hyyA-3k70B:
undetectable		 2hyyA-3k70B:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		4 LEU A 168
VAL A 111
VAL A 147
ILE A 191
 None
None
None
GP7  A 435 (-4.6A)
 0.97A 2hyyA-3k7tA:
undetectable		 2hyyA-3k7tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 LEU A 246
VAL A 182
ILE A 252
ARG A  58
 None
 1.02A 2hyyA-3l6cA:
undetectable		 2hyyA-3l6cA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		4 LEU A 246
VAL A 182
ILE A 252
ARG A  58
 None
 1.03A 2hyyA-3l6rA:
undetectable		 2hyyA-3l6rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		4 LEU A  24
VAL A 119
VAL A  71
ILE A   4
 None
 1.02A 2hyyA-3m2tA:
undetectable		 2hyyA-3m2tA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  49
LYS A  72
VAL A 104
ARG A 165
 XFE  A 351 (-4.2A)
None
None
TPO  A 197 ( 3.1A)
 1.01A 2hyyA-3mvjA:
20.8		 2hyyA-3mvjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		4 LEU A 266
VAL A 164
VAL A  24
ILE A  55
 None
 1.00A 2hyyA-3nfbA:
undetectable		 2hyyA-3nfbA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
PROTEIN AIR2

(Saccharomyces
cerevisiae) 		PF00098
(zf-CCHC)
PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		5 LEU B 145
VAL A 351
VAL A 374
ILE A 361
ARG A 319
 None
 1.42A 2hyyA-3nybB:
undetectable		 2hyyA-3nybB:
14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 0.91A 2hyyA-3ppzA:
28.9		 2hyyA-3ppzA:
33.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE

(Escherichia
coli) 		PF03629
(SASA) 		4 LEU A 164
VAL A 175
ILE A 115
ARG A 120
 None
 1.01A 2hyyA-3pt5A:
undetectable		 2hyyA-3pt5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 494
VAL A  73
VAL A 311
ILE A 460
 MRD  A 581 ( 4.9A)
None
None
None
 0.90A 2hyyA-3q9tA:
undetectable		 2hyyA-3q9tA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtd PMBA PROTEIN

(Pseudomonas
aeruginosa) 		PF01523
(PmbA_TldD) 		4 LEU A 300
VAL A 424
VAL A 253
ILE A 428
 None
 0.99A 2hyyA-3qtdA:
undetectable		 2hyyA-3qtdA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 104
VAL A 305
VAL A 301
ILE A 331
 None
 0.88A 2hyyA-3ramA:
undetectable		 2hyyA-3ramA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  50
LYS A  73
VAL A  98
ILE A 116
ARG A 165
 I85  A 350 (-3.7A)
I85  A 350 (-2.8A)
None
None
None
 0.99A 2hyyA-3sheA:
18.4		 2hyyA-3sheA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2

(Burkholderia
pseudomallei) 		PF00793
(DAHP_synth_1) 		4 LEU A  26
VAL A 133
VAL A 103
ILE A  91
 None
 1.02A 2hyyA-3tmqA:
undetectable		 2hyyA-3tmqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
VAL A 113
ILE A 127
 None
ANK  A 401 (-2.4A)
None
None
 0.84A 2hyyA-3vn9A:
22.1		 2hyyA-3vn9A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
LYS A  98
VAL A 212
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 (-2.7A)
CHU  A 403 ( 4.0A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 1.19A 2hyyA-3wigA:
22.5		 2hyyA-3wigA:
25.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
LYS A 868
VAL A 899
ARG A1027
 LEV  A1201 ( 3.8A)
None
None
None
 0.62A 2hyyA-3wzdA:
25.6		 2hyyA-3wzdA:
38.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 LEU A 137
VAL A  38
ILE A 114
ARG A 268
 None
 0.95A 2hyyA-4a5oA:
undetectable		 2hyyA-4a5oA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apw ALP12

(Clostridium
tetani) 		no annotation 4 LEU A 117
VAL A 106
VAL A 321
ILE A 152
 None
 0.97A 2hyyA-4apwA:
undetectable		 2hyyA-4apwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 LEU A 131
VAL A 103
VAL A  25
ILE A 463
 None
 0.98A 2hyyA-4av6A:
undetectable		 2hyyA-4av6A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  68
VAL A 123
ILE A 137
ARG A 184
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-4.4A)
None
None
 0.85A 2hyyA-4b6lA:
23.0		 2hyyA-4b6lA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)

(Trypanosoma
brucei) 		PF00025
(Arf) 		4 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 1.00A 2hyyA-4basA:
undetectable		 2hyyA-4basA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  42
LYS A  65
VAL A  94
ILE A 108
 XZN  A1317 (-3.6A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
 0.86A 2hyyA-4bc6A:
21.8		 2hyyA-4bc6A:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuk D-LACTATE
DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 194
VAL A 290
VAL A 227
ILE A 230
 None
 1.00A 2hyyA-4cukA:
undetectable		 2hyyA-4cukA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  15
LYS A  38
VAL A  58
VAL A  68
ARG A 134
 BX7  A 401 (-3.7A)
BX7  A 401 ( 4.0A)
None
None
None
 1.06A 2hyyA-4eutA:
12.2		 2hyyA-4eutA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.5A)
None
None
 0.72A 2hyyA-4euuA:
15.8		 2hyyA-4euuA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0u ALLOPHYCOCYANIN
ALPHA CHAIN
ALLOPHYCOCYANIN,
BETA SUBUNIT

(Synechococcus
elongatus) 		PF00502
(Phycobilisome) 		4 LEU B  24
VAL A  52
ILE A  44
ARG A  86
 None
None
None
CYC  A 201 (-3.0A)
 0.92A 2hyyA-4f0uB:
undetectable		 2hyyA-4f0uB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 650
VAL A 636
VAL A 741
ILE A 642
 LEU  A 650 ( 0.6A)
VAL  A 636 ( 0.5A)
VAL  A 741 ( 0.5A)
ILE  A 642 ( 0.6A)
 0.90A 2hyyA-4flxA:
undetectable		 2hyyA-4flxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 598
LYS A 621
VAL A 651
ILE A 885
 924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
 0.42A 2hyyA-4g34A:
20.6		 2hyyA-4g34A:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 855
LYS A 882
VAL A 911
ARG A 975
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.7A)
None
None
 1.03A 2hyyA-4gl9A:
20.2		 2hyyA-4gl9A:
35.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon)
PF08646
(Rep_fac-A_C)
PF16900
(REPA_OB_2) 		4 LEU C 485
VAL C 473
VAL C 477
ILE C 600
 None
 0.89A 2hyyA-4gnxC:
undetectable		 2hyyA-4gnxC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN

(Synechococcus
elongatus) 		PF00502
(Phycobilisome) 		4 LEU A  24
VAL B  52
ILE B  44
ARG B  84
 CYC  B 202 ( 4.6A)
None
None
CYC  B 201 (-2.8A)
 1.02A 2hyyA-4h0mA:
undetectable		 2hyyA-4h0mA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h18 CMT1

(Corynebacterium
glutamicum) 		PF00756
(Esterase) 		4 LEU A 256
VAL A 269
ILE A 329
ARG A 183
 None
 0.99A 2hyyA-4h18A:
undetectable		 2hyyA-4h18A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		4 LEU A 169
VAL A 294
VAL A 238
ILE A 192
 None
 0.89A 2hyyA-4hjwA:
undetectable		 2hyyA-4hjwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 406
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-3.8A)
T28  A 701 ( 3.8A)
None
None
 0.90A 2hyyA-4idtA:
21.6		 2hyyA-4idtA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		4 VAL A  72
VAL A  68
ILE A  98
ARG A  57
 None
 1.01A 2hyyA-4irxA:
undetectable		 2hyyA-4irxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 LEU A 135
VAL A 111
VAL A 129
ILE A  88
ARG A  76
 None
 1.50A 2hyyA-4iwnA:
undetectable		 2hyyA-4iwnA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospora
viridis) 		PF00171
(Aldedh) 		4 LEU A 206
VAL A 179
VAL A 201
ARG A 143
 LEU  A 206 ( 0.6A)
VAL  A 179 ( 0.6A)
VAL  A 201 ( 0.6A)
ARG  A 143 ( 0.6A)
 0.84A 2hyyA-4jbeA:
undetectable		 2hyyA-4jbeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdu AEROTOLERANCE-RELATE
D MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF00092
(VWA) 		4 VAL A 225
VAL A 194
ILE A 271
ARG A 117
 None
 0.90A 2hyyA-4jduA:
undetectable		 2hyyA-4jduA:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
 0.84A 2hyyA-4k11A:
30.7		 2hyyA-4k11A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
LYS A 295
VAL A 313
ILE A 336
ARG A 385
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
None
 1.34A 2hyyA-4lggA:
30.0		 2hyyA-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 313
VAL A 323
ILE A 336
ARG A 385
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 1.08A 2hyyA-4lggA:
30.0		 2hyyA-4lggA:
47.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		4 LYS A 261
VAL A 242
VAL A 234
ILE A 260
 None
 0.99A 2hyyA-4mz1A:
undetectable		 2hyyA-4mz1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		4 LEU A  23
VAL A 166
VAL A 116
ILE A 360
 None
 0.91A 2hyyA-4nesA:
undetectable		 2hyyA-4nesA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oky RESTRICTION
ENDONUCLEASE PVURTS1
I

(Proteus
vulgaris) 		no annotation 4 LEU C   8
LYS C  13
VAL C  28
ILE C  14
 None
 0.84A 2hyyA-4okyC:
undetectable		 2hyyA-4okyC:
21.17