SIMILAR PATTERNS OF AMINO ACIDS FOR 2HXF_B_TA1B601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		5 VAL A 192
LEU A 241
LEU A 245
ARG A  54
GLY A  69
 None
 1.01A 2hxfB-1cs1A:
2.6		 2hxfB-1cs1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		5 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.20A 2hxfB-1kzhA:
2.4		 2hxfB-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW

(Thermotoga
maritima) 		PF01795
(Methyltransf_5) 		5 VAL A 252
ASP A 249
GLU A 248
LEU A  20
GLY A 286
 None
 1.19A 2hxfB-1m6yA:
1.5		 2hxfB-1m6yA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
None
 1.23A 2hxfB-1n5xA:
undetectable		 2hxfB-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL B 122
LEU B 235
LEU B 233
THR B 234
GLY B  48
 None
 1.06A 2hxfB-1n60B:
undetectable		 2hxfB-1n60B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.16A 2hxfB-1nowA:
undetectable		 2hxfB-1nowA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ASP A 183
HIS A 219
LEU A 277
THR A 273
GLY A  28
 None
 0.99A 2hxfB-1qgdA:
undetectable		 2hxfB-1qgdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvi HYPOTHETICAL UPF0054
PROTEIN TM1509

(Thermotoga
maritima) 		PF02130
(UPF0054) 		5 VAL A  60
ASP A  59
LEU A  21
LEU A  14
PRO A  78
 None
 1.16A 2hxfB-1tviA:
undetectable		 2hxfB-1tviA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1typ TRYPANOTHIONE
REDUCTASE

(Crithidia
fasciculata) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 2hxfB-1typA:
undetectable		 2hxfB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjm BETA-SPECTRIN III

(Homo sapiens) 		PF15410
(PH_9) 		5 GLU A   8
LEU A  89
LEU A  87
ARG A  69
GLY A   1
 None
 1.01A 2hxfB-1wjmA:
undetectable		 2hxfB-1wjmA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 1.04A 2hxfB-1xa6A:
undetectable		 2hxfB-1xa6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 LEU A 120
SER A  43
LEU A 129
THR A 148
GLY A 133
 None
 1.18A 2hxfB-2abqA:
6.2		 2hxfB-2abqA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 LEU A  75
PHE A  39
LEU A  72
THR A  71
GLY A  58
 None
 1.19A 2hxfB-2b3oA:
undetectable		 2hxfB-2b3oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4z CYTOCHROME C

(Bos taurus) 		PF00034
(Cytochrom_C) 		5 GLU A  21
LEU A  68
HIS A  18
LEU A  94
GLY A  34
 None
HEM  A 500 (-4.2A)
HEM  A 500 (-3.3A)
None
None
 1.21A 2hxfB-2b4zA:
undetectable		 2hxfB-2b4zA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521

(Archaeoglobus
fulgidus) 		PF01661
(Macro) 		5 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.18A 2hxfB-2bfrA:
undetectable		 2hxfB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.16A 2hxfB-2bi0A:
undetectable		 2hxfB-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		5 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 1.03A 2hxfB-2cbzA:
undetectable		 2hxfB-2cbzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6l LECTIN, GALACTOSE
BINDING, SOLUBLE 9

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		5 VAL X 111
LEU X 141
LEU X 139
THR X  36
PRO X  91
 None
 1.23A 2hxfB-2d6lX:
undetectable		 2hxfB-2d6lX:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.07A 2hxfB-2gjxA:
undetectable		 2hxfB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 5 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.11A 2hxfB-2gk1I:
undetectable		 2hxfB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		5 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
 VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
 0.97A 2hxfB-2jf4A:
undetectable		 2hxfB-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mab ACINIFORM SPIDROIN

(Nephila
antipodiana) 		PF11260
(Spidroin_MaSp) 		5 VAL A  38
SER A  99
LEU A  73
THR A  74
GLY A  46
 None
 1.21A 2hxfB-2mabA:
undetectable		 2hxfB-2mabA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Pseudomonas
aeruginosa) 		PF01242
(PTPS) 		5 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.06A 2hxfB-2obaA:
undetectable		 2hxfB-2obaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		5 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.10A 2hxfB-2osaA:
undetectable		 2hxfB-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 VAL A 301
ASP A 303
LEU A  20
HIS A 321
PHE A  31
LEU A  16
 None
 1.41A 2hxfB-2ovlA:
undetectable		 2hxfB-2ovlA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 LEU A 407
PHE A 196
LEU A 401
ARG A 170
GLY A 373
 None
None
None
None
ATP  A 500 (-3.6A)
 1.16A 2hxfB-2paaA:
2.6		 2hxfB-2paaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		5 ASP A 463
LEU A 419
LEU A 452
THR A 455
GLY A 388
 None
None
None
None
EDO  A 604 ( 4.2A)
 1.21A 2hxfB-2qa1A:
2.6		 2hxfB-2qa1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.11A 2hxfB-2wl1A:
undetectable		 2hxfB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
 None
 1.23A 2hxfB-2wtbA:
undetectable		 2hxfB-2wtbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
SUBUNIT 4 ISOFORM 1
CYTOCHROME C OXIDASE
SUBUNIT 5A

(Bos taurus) 		PF02284
(COX5A)
PF02936
(COX4) 		5 GLU E 103
LEU D  40
PHE E  61
LEU D  59
GLY E 105
 None
 1.09A 2hxfB-2y69E:
undetectable		 2hxfB-2y69E:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		5 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.98A 2hxfB-2yysA:
undetectable		 2hxfB-2yysA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 VAL A 488
LEU A 622
PHE A 614
LEU A 618
GLY A 495
 None
 1.23A 2hxfB-3ak5A:
undetectable		 2hxfB-3ak5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		5 VAL A 484
LEU A 555
SER A 523
LEU A 539
GLY A 514
 None
 1.15A 2hxfB-3azqA:
undetectable		 2hxfB-3azqA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5m UNCHARACTERIZED
PROTEIN

(Rhodopirellula
baltica) 		PF04289
(DUF447) 		5 VAL A   7
LEU A  26
LEU A  38
ARG A 121
GLY A  55
 None
 1.22A 2hxfB-3b5mA:
undetectable		 2hxfB-3b5mA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		6 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.6A)
None
None
None
None
 1.17A 2hxfB-3b9jB:
undetectable		 2hxfB-3b9jB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 LEU A  62
PHE A 211
LEU A 212
ARG A 104
PRO A 188
 None
 1.17A 2hxfB-3cklA:
undetectable		 2hxfB-3cklA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.12A 2hxfB-3e9yA:
undetectable		 2hxfB-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 360
HIS A 459
PHE A 406
LEU A 189
GLY A 391
 None
 1.23A 2hxfB-3fw8A:
undetectable		 2hxfB-3fw8A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzr UNCHARACTERIZED
PROTEIN WITH A
NTF2-LIKE FOLD

(Caulobacter
vibrioides) 		PF14534
(DUF4440) 		5 LEU A 139
HIS A  83
LEU A 137
THR A 138
GLY A  70
 None
 1.15A 2hxfB-3gzrA:
undetectable		 2hxfB-3gzrA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 VAL A 237
GLU A 233
LEU A 294
LEU A 289
THR A 290
 None
 0.95A 2hxfB-3hwwA:
undetectable		 2hxfB-3hwwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lke ENOYL-COA HYDRATASE

(Bacillus
halodurans) 		PF00378
(ECH_1) 		5 ASP A 146
LEU A  54
LEU A  19
ARG A 126
GLY A 114
 None
 1.15A 2hxfB-3lkeA:
2.6		 2hxfB-3lkeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 VAL A 277
GLU A 273
LEU A 289
SER A 305
LEU A 258
 None
 1.04A 2hxfB-3lmdA:
undetectable		 2hxfB-3lmdA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmz PUTATIVE SUGAR
ISOMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		5 VAL A 127
LEU A  62
LEU A  58
THR A  61
GLY A 107
 None
 1.18A 2hxfB-3lmzA:
undetectable		 2hxfB-3lmzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.20A 2hxfB-3lscA:
2.7		 2hxfB-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwd 6-PHOSPHOGLUCONOLACT
ONASE

(Chromohalobacter
salexigens) 		PF01182
(Glucosamine_iso) 		5 LEU A 100
LEU A 173
THR A 172
ARG A  69
GLY A 131
 None
 0.80A 2hxfB-3lwdA:
undetectable		 2hxfB-3lwdA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		6 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
None
 1.19A 2hxfB-3ns1B:
undetectable		 2hxfB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		5 LEU A 104
LEU A 177
THR A 176
ARG A  73
GLY A 135
 None
 0.76A 2hxfB-3nwpA:
undetectable		 2hxfB-3nwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		5 VAL A 341
GLU A 382
LEU A 490
SER A 329
LEU A 493
 None
None
None
None
CL  A 565 ( 4.4A)
 1.14A 2hxfB-3ujhA:
undetectable		 2hxfB-3ujhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		5 VAL A 118
LEU A 209
LEU A 185
THR A 186
GLY A 105
 None
 1.19A 2hxfB-3w4rA:
2.6		 2hxfB-3w4rA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		5 VAL A 118
LEU A 209
LEU A 185
THR A 186
GLY A 105
 None
 1.19A 2hxfB-3wl1A:
undetectable		 2hxfB-3wl1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		5 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 0.97A 2hxfB-4c3zA:
undetectable		 2hxfB-4c3zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		5 VAL B 237
LEU B 157
LEU B 136
THR B 159
GLY B  40
 None
 1.08A 2hxfB-4ckeB:
undetectable		 2hxfB-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		5 VAL A  29
GLU A  27
LEU A  88
LEU A  92
GLY A  15
 None
 1.04A 2hxfB-4db3A:
undetectable		 2hxfB-4db3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		5 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.17A 2hxfB-4db4A:
undetectable		 2hxfB-4db4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emi TODA

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.10A 2hxfB-4emiA:
undetectable		 2hxfB-4emiA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoj REGF PROTEIN

(Neisseria
gonorrhoeae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 VAL A  93
LEU A 158
LEU A 175
ARG A 185
GLY A 144
 ACT  A 303 (-3.9A)
None
None
None
None
 0.98A 2hxfB-4hojA:
undetectable		 2hxfB-4hojA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Influenza A
virus;
Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		5 VAL A 104
LEU A  46
PHE A 274
LEU A 275
ARG A  52
 None
 1.14A 2hxfB-4iq4A:
4.0		 2hxfB-4iq4A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.91A 2hxfB-4j7qA:
undetectable		 2hxfB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc6 RIBOSOME-RECYCLING
FACTOR

(Mycobacterium
tuberculosis) 		PF01765
(RRF) 		5 LEU A 105
SER A  85
LEU A 113
THR A  29
GLY A  35
 None
 0.97A 2hxfB-4kc6A:
undetectable		 2hxfB-4kc6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		5 LEU A 211
LEU A 207
ARG A 216
PRO A  56
GLY A  58
 None
 1.17A 2hxfB-4m9dA:
undetectable		 2hxfB-4m9dA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 GLU E 775
LEU E 532
HIS E 519
LEU E 562
GLY E 571
 None
 1.10A 2hxfB-4mh0E:
undetectable		 2hxfB-4mh0E:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 VAL A 857
GLU A 856
LEU A 772
LEU A 776
GLY A 786
 None
 1.06A 2hxfB-4n1aA:
undetectable		 2hxfB-4n1aA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf1 ACETYLGLUTAMATE
KINASE

(Xylella
fastidiosa) 		PF04768
(NAT) 		5 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.15A 2hxfB-4nf1A:
undetectable		 2hxfB-4nf1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 VAL A 857
GLU A 856
LEU A 772
LEU A 776
GLY A 786
 None
 1.01A 2hxfB-4nh0A:
undetectable		 2hxfB-4nh0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 ASP A 199
GLU A 209
LEU A 254
LEU A 257
GLY A 207
 None
 1.17A 2hxfB-4qb9A:
undetectable		 2hxfB-4qb9A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 GLU A 317
SER A 338
LEU A 298
THR A 292
GLY A 310
 None
 1.05A 2hxfB-4qnlA:
undetectable		 2hxfB-4qnlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		5 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.13A 2hxfB-4ur8A:
undetectable		 2hxfB-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		5 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
 None
 1.05A 2hxfB-4wisA:
undetectable		 2hxfB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		5 VAL A 152
LEU A 310
LEU A 314
PRO A 180
GLY A 155
 None
 1.10A 2hxfB-4x9tA:
undetectable		 2hxfB-4x9tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 VAL A 329
LEU A 403
LEU A 371
THR A 372
PRO A 409
GLY A 295
 None
FAD  A3004 (-4.7A)
None
None
None
None
 1.22A 2hxfB-4yswA:
undetectable		 2hxfB-4yswA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn2 PSLG

(Pseudomonas
aeruginosa) 		PF00150
(Cellulase) 		5 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.19A 2hxfB-4zn2A:
undetectable		 2hxfB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aid MEP2

(Candida
albicans) 		PF00909
(Ammonium_transp) 		5 LEU A 381
LEU A 355
THR A 353
PRO A 316
GLY A 345
 None
 1.12A 2hxfB-5aidA:
undetectable		 2hxfB-5aidA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		5 LEU A 376
SER A 300
PHE A 321
LEU A 374
THR A 375
 None
CDP  A 411 (-2.7A)
CDP  A 411 (-4.4A)
None
None
 1.23A 2hxfB-5bo6A:
undetectable		 2hxfB-5bo6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5s UNCONVENTIONAL
MYOSIN-IXB

(Homo sapiens) 		PF00620
(RhoGAP) 		5 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.17A 2hxfB-5c5sA:
undetectable		 2hxfB-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.02A 2hxfB-5cyrB:
undetectable		 2hxfB-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0q BETA-GLUCURONIDASE

(Acidobacterium
capsulatum) 		PF03662
(Glyco_hydro_79n) 		5 VAL A 453
GLU A 451
LEU A 370
LEU A 379
THR A 380
 None
 1.03A 2hxfB-5g0qA:
2.8		 2hxfB-5g0qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5y NON-LEE ENCODED
EFFECTOR PROTEIN
NLEB

(Escherichia
coli) 		no annotation 5 ASP A  37
LEU A 264
LEU A 190
PRO A  41
GLY A 211
 None
 0.98A 2hxfB-5h5yA:
undetectable		 2hxfB-5h5yA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 LEU A  77
PHE A  41
LEU A  74
THR A  73
GLY A  60
 None
 1.18A 2hxfB-5i6vA:
undetectable		 2hxfB-5i6vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 5 LEU A 182
SER A 103
LEU A 178
THR A 180
GLY A 144
 None
 1.23A 2hxfB-5j4rA:
undetectable		 2hxfB-5j4rA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC
SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ASP B 108
LEU A 325
SER A 120
LEU A 322
THR A 323
 None
None
None
None
GCP  A 401 ( 4.8A)
 1.12A 2hxfB-5l3rB:
undetectable		 2hxfB-5l3rB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		5 VAL A 339
GLU A 358
LEU A 255
LEU A 310
ARG A 316
 None
 1.07A 2hxfB-5ldtA:
undetectable		 2hxfB-5ldtA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A  26
GLU A  27
LEU A 215
HIS A 227
PRO A 357
 None
 1.08A 2hxfB-5mjsA:
54.4		 2hxfB-5mjsA:
59.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp4 PROTOPLAST SECRETED
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		5 LEU A 141
HIS A 184
SER A 177
LEU A 150
GLY A 117
 None
 1.19A 2hxfB-5mp4A:
3.0		 2hxfB-5mp4A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		5 VAL Q 278
ASP Q 277
LEU Q 342
LEU Q 338
THR Q 341
 None
 1.13A 2hxfB-5mpdQ:
undetectable		 2hxfB-5mpdQ:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 647
HIS A 612
LEU A 641
THR A 645
GLY A 600
 None
 1.17A 2hxfB-5myvA:
undetectable		 2hxfB-5myvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 5 ASP A 731
LEU A 159
LEU A 269
THR A 158
PRO A 720
 None
 1.17A 2hxfB-5mz9A:
undetectable		 2hxfB-5mz9A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
ASP B  26
GLU B  27
HIS B 229
SER B 236
THR B 276
 None
 1.17A 2hxfB-5n5nB:
54.6		 2hxfB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
ASP B  26
GLU B  27
LEU B 217
HIS B 229
THR B 276
 None
 1.08A 2hxfB-5n5nB:
54.6		 2hxfB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
GLU B  27
HIS B 229
SER B 236
PHE B 272
THR B 276
PRO B 360
GLY B 370
 None
 0.98A 2hxfB-5n5nB:
54.6		 2hxfB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
GLU B  27
LEU B 217
HIS B 229
PHE B 272
THR B 276
PRO B 360
GLY B 370
 None
 0.89A 2hxfB-5n5nB:
54.6		 2hxfB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
LEU B 217
HIS B 229
PHE B 272
LEU B 275
THR B 276
PRO B 360
GLY B 370
 None
 0.88A 2hxfB-5n5nB:
54.6		 2hxfB-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twt PEROXIDASE PVI9

(Panicum
virgatum) 		PF00141
(peroxidase) 		5 ASP A  57
LEU A  99
PHE A  75
LEU A  39
GLY A  61
 None
None
SO4  A 304 (-4.5A)
None
None
 1.22A 2hxfB-5twtA:
undetectable		 2hxfB-5twtA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
GLU B  27
LEU B 215
THR B 274
PRO B 358
GLY B 360
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 (-4.7A)
None
TA1  B 502 (-3.6A)
 0.78A 2hxfB-5w3jB:
38.9		 2hxfB-5w3jB:
75.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
GLU B  27
SER B 234
PRO B 358
GLY B 360
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.9A)
None
TA1  B 502 (-3.6A)
 0.93A 2hxfB-5w3jB:
38.9		 2hxfB-5w3jB:
75.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 5 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
 None
 1.07A 2hxfB-6brdA:
undetectable		 2hxfB-6brdA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 5 VAL A 150
LEU A 306
SER A 152
LEU A 304
THR A 289
 None
 1.22A 2hxfB-6f9mA:
undetectable		 2hxfB-6f9mA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 5 HIS B 384
SER B  62
THR B 150
ARG B 133
GLY A1187
 None
 1.06A 2hxfB-6f9nB:
undetectable		 2hxfB-6f9nB:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 5 VAL A  24
GLU A  28
LEU A1023
THR A1020
GLY A1007
 None
 1.11A 2hxfB-6fuyA:
undetectable		 2hxfB-6fuyA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 5 VAL A  55
ASP A  54
SER A 105
LEU A  37
GLY A  32
 None
 1.04A 2hxfB-6g21A:
undetectable		 2hxfB-6g21A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 5 VAL M 297
LEU M 321
SER M 240
LEU M  68
GLY M 456
 None
None
None
3PE  M 503 ( 4.2A)
None
 1.19A 2hxfB-6g2jM:
undetectable		 2hxfB-6g2jM:
11.26