SIMILAR PATTERNS OF AMINO ACIDS FOR 2HW2_A_RFPA1200_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1br2 | MYOSIN (Gallus gallus) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | PHE A 332ALA A 233GLY A 235THR A 335LEU A 624 | None | 1.02A | 2hw2A-1br2A:0.0 | 2hw2A-1br2A:10.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz6 | ESTRADIOL 17BETA-DEHYDROGENASE 4 (Rattusnorvegicus) |
PF00106(adh_short) | 5 | GLY A 101SER A 75GLY A 170LEU A 171LEU A 174 | NAI A1306 (-3.6A)NAI A1306 (-3.2A)NoneNoneNone | 0.92A | 2hw2A-1gz6A:0.0 | 2hw2A-1gz6A:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i1q | ANTHRANILATESYNTHASE COMPONENT I (Salmonellaenterica) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | ALA A 452GLY A 450THR A 464SER A 311GLY A 157 | None | 1.02A | 2hw2A-1i1qA:0.0 | 2hw2A-1i1qA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i8q | HYALURONATE LYASE (Streptococcusagalactiae) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 5 | ALA A 645GLY A 643MET A 895GLY A 840LEU A 830 | None | 0.94A | 2hw2A-1i8qA:0.4 | 2hw2A-1i8qA:11.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jx2 | MYOSIN-2 HEAVYCHAIN,DYNAMIN-A (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | PHE A 335ALA A 235GLY A 237THR A 338LEU A 622 | None | 0.99A | 2hw2A-1jx2A:0.0 | 2hw2A-1jx2A:9.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kph | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 1 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72THR A 32SER A 34LEU A 68LEU A 62 | SAH A1900 (-3.1A)SAH A1900 (-4.1A)SAH A1900 ( 3.6A)NoneNone | 0.97A | 2hw2A-1kphA:0.0 | 2hw2A-1kphA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1e | MYCOLIC ACIDSYNTHASE (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72THR A 32SER A 34LEU A 68LEU A 62 | SAH A 900 (-3.1A)SAH A 900 (-4.1A)SAH A 900 ( 2.7A)NoneNone | 0.99A | 2hw2A-1l1eA:0.0 | 2hw2A-1l1eA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pm2 | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1BETA CHAIN (Escherichiacoli) |
PF00268(Ribonuc_red_sm) | 5 | GLY A 20THR A 164MET A 261LEU A 252LEU A 249 | None | 0.94A | 2hw2A-1pm2A:undetectable | 2hw2A-1pm2A:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1po0 | IRON(III) DICITRATETRANSPORT PROTEINFECA PRECURSOR (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ALA A 608GLY A 639GLY A 595LEU A 594LEU A 597 | None | 1.08A | 2hw2A-1po0A:0.0 | 2hw2A-1po0A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tf1 | NEGATIVE REGULATOROF ALLANTOIN ANDGLYOXYLATEUTILIZATION OPERONS (Escherichiacoli) |
PF01614(IclR) | 5 | ALA A 74GLY A 70GLY A 61LEU A 44LEU A 60 | None | 1.08A | 2hw2A-1tf1A:undetectable | 2hw2A-1tf1A:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7w | COENZYME ABIOSYNTHESISBIFUNCTIONAL PROTEINCOABC (Escherichiacoli) |
PF04127(DFP) | 6 | ALA A 328GLY A 326MET A 216GLY A 389LEU A 392LEU A 391 | CTP A 500 ( 4.0A)CTP A 500 (-3.6A)NoneNoneNoneNone | 1.33A | 2hw2A-1u7wA:undetectable | 2hw2A-1u7wA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usc | PUTATIVE STYRENEMONOOXYGENASE SMALLCOMPONENT (Thermusthermophilus) |
PF01613(Flavin_Reduct) | 5 | PHE A 70GLY A 51GLY A 62LEU A 64LEU A 63 | None | 1.06A | 2hw2A-1uscA:undetectable | 2hw2A-1uscA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbg | PYRUVATE,ORTHOPHOSPHATE DIKINASE (Zea mays) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 5 | ALA A 867MET A 528GLY A 525LEU A 524LEU A 520 | None | 1.05A | 2hw2A-1vbgA:undetectable | 2hw2A-1vbgA:10.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkj | EXTENDED-SPECTRUMBETA-LACTAMASE (Klebsiellaaerogenes) |
PF00144(Beta-lactamase) | 5 | ALA A 222GLY A 224MET A 175LEU A 180LEU A 183 | None | 0.85A | 2hw2A-1zkjA:undetectable | 2hw2A-1zkjA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bs4 | QUINOL-FUMARATEREDUCTASE DIHEMECYTOCHROME B SUBUNITC (Wolinellasuccinogenes) |
PF01127(Sdh_cyt) | 5 | PHE C 85GLY C 43GLY C 186LEU C 187LEU C 190 | NoneNoneHEM C1255 (-3.4A)HEM C1255 (-4.8A)HEM C1255 (-4.2A) | 1.07A | 2hw2A-2bs4C:undetectable | 2hw2A-2bs4C:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d07 | G/TMISMATCH-SPECIFICTHYMINE DNAGLYCOSYLASE (Homo sapiens) |
PF03167(UDG) | 5 | ALA A 146GLY A 149THR A 196GLY A 188LEU A 128 | None | 1.01A | 2hw2A-2d07A:undetectable | 2hw2A-2d07A:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ew2 | 2-DEHYDROPANTOATE2-REDUCTASE,PUTATIVE (Enterococcusfaecalis) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | ALA A 10GLY A 12MET A 18GLY A 172LEU A 173 | None | 1.03A | 2hw2A-2ew2A:undetectable | 2hw2A-2ew2A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f8m | RIBOSE 5-PHOSPHATEISOMERASE (Plasmodiumfalciparum) |
PF06026(Rib_5-P_isom_A) | 5 | ALA A 102GLY A 100THR A 55SER A 56GLY A 120 | None | 1.07A | 2hw2A-2f8mA:undetectable | 2hw2A-2f8mA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fff | PENICILLIN-BINDINGPROTEIN 1B (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 5 | ALA B 467THR B 524MET B 616GLY B 618LEU B 620 | None | 1.08A | 2hw2A-2fffB:undetectable | 2hw2A-2fffB:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g2x | HYPOTHETICAL PROTEINPP5205 (Pseudomonasputida) |
PF01878(EVE) | 5 | THR A 74SER A 80GLY A 22LEU A 21LEU A 18 | None | 1.05A | 2hw2A-2g2xA:undetectable | 2hw2A-2g2xA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijz | PROBABLE M18-FAMILYAMINOPEPTIDASE 2 (Pseudomonasaeruginosa) |
PF02127(Peptidase_M18) | 5 | ALA A 233GLY A 408GLY A 244LEU A 245LEU A 248 | None | 0.64A | 2hw2A-2ijzA:undetectable | 2hw2A-2ijzA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjf | L-LYSINE EPSILONAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF00202(Aminotran_3) | 5 | ALA A 390GLY A 384THR A 420GLY A 204LEU A 205 | None | 1.02A | 2hw2A-2jjfA:undetectable | 2hw2A-2jjfA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p8u | HYDROXYMETHYLGLUTARYL-COA SYNTHASE,CYTOPLASMIC (Homo sapiens) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 5 | GLY A 371SER A 334MET A 278LEU A 229LEU A 226 | None | 1.09A | 2hw2A-2p8uA:undetectable | 2hw2A-2p8uA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q49 | PROBABLEN-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Arabidopsisthaliana) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | PHE A 42GLY A 345GLY A 334LEU A 337LEU A 35 | None | 1.06A | 2hw2A-2q49A:undetectable | 2hw2A-2q49A:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q7t | PROTEIN TRAI (Escherichiacoli) |
PF08751(TrwC) | 5 | GLY A 170THR A 136GLY A 58LEU A 60LEU A 55 | None | 1.00A | 2hw2A-2q7tA:undetectable | 2hw2A-2q7tA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjj | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Novosphingobiumaromaticivorans) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 371MET A 91GLY A 291LEU A 292LEU A 295 | None | 1.07A | 2hw2A-2qjjA:undetectable | 2hw2A-2qjjA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qz6 | BETA-LACTAMASE (Pseudomonasfluorescens) |
PF00144(Beta-lactamase) | 5 | ALA A 221GLY A 223MET A 174LEU A 179LEU A 182 | None | 0.94A | 2hw2A-2qz6A:undetectable | 2hw2A-2qz6A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x05 | EXO-BETA-D-GLUCOSAMINIDASE (Amycolatopsisorientalis) |
PF00703(Glyco_hydro_2)PF02837(Glyco_hydro_2_N) | 5 | PHE A 656ALA A 377ASN A 385GLY A 361LEU A 644 | None | 1.09A | 2hw2A-2x05A:undetectable | 2hw2A-2x05A:8.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xd3 | MALTOSE/MALTODEXTRIN-BINDING PROTEIN (Streptococcuspneumoniae) |
PF13416(SBP_bac_8) | 5 | ALA A 144GLY A 305GLY A 80LEU A 81LEU A 84 | None | 1.05A | 2hw2A-2xd3A:undetectable | 2hw2A-2xd3A:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xfs | ORF12 (Streptomycesclavuligerus) |
PF13354(Beta-lactamase2) | 6 | PHE A 385PHE A 276ALA A 173SER A 234GLY A 316LEU A 315 | J01 A 600 (-4.7A)NoneJ01 A 600 ( 4.0A)J01 A 600 (-3.4A)NoneNone | 1.16A | 2hw2A-2xfsA:undetectable | 2hw2A-2xfsA:15.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z37 | CHITINASE (Brassica juncea) |
PF00182(Glyco_hydro_19) | 5 | PHE A 205GLY A 259GLY A 275LEU A 282LEU A 280 | None | 1.05A | 2hw2A-2z37A:undetectable | 2hw2A-2z37A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bhq | TRANSCRIPTIONALREGULATOR (Mesorhizobiumjaponicum) |
PF00440(TetR_N)PF14246(TetR_C_7) | 5 | PHE A 201MET A 87GLY A 90LEU A 91LEU A 94 | None | 1.02A | 2hw2A-3bhqA:undetectable | 2hw2A-3bhqA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3daq | DIHYDRODIPICOLINATESYNTHASE (Staphylococcusaureus) |
PF00701(DHDPS) | 5 | GLY A 189ASN A 211GLY A 238LEU A 241LEU A 240 | GOL A 295 (-3.8A)NoneNoneNoneNone | 1.07A | 2hw2A-3daqA:undetectable | 2hw2A-3daqA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dme | CONSERVED EXPORTEDPROTEIN (Bordetellapertussis) |
PF01266(DAO) | 5 | PHE A 292GLY A 232SER A 48GLY A 255LEU A 256 | NoneFAD A 500 ( 4.6A)FAD A 500 ( 2.9A)NoneNone | 1.00A | 2hw2A-3dmeA:undetectable | 2hw2A-3dmeA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fvv | UNCHARACTERIZEDPROTEIN (Bordetellapertussis) |
PF12710(HAD) | 5 | ALA A 136THR A 115GLY A 67LEU A 69LEU A 68 | NoneSO4 A 233 (-3.8A)NoneNoneNone | 1.07A | 2hw2A-3fvvA:undetectable | 2hw2A-3fvvA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gpr | RHODOCETIN SUBUNITDELTARHODOCETIN SUBUNITGAMMA (Calloselasmarhodostoma) |
PF00059(Lectin_C) | 6 | ALA D4048GLY D4051ASN C3095GLY D4066LEU D4065LEU D4067 | None | 1.12A | 2hw2A-3gprD:undetectable | 2hw2A-3gprD:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1l | MITOCHONDRIALUBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEXCORE PROTEIN I (Gallus gallus) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 5 | PHE A 216ALA A 199GLY A 38GLY A 22LEU A 23 | None | 1.07A | 2hw2A-3h1lA:undetectable | 2hw2A-3h1lA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hxw | ALANYL-TRNASYNTHETASE (Escherichiacoli) |
PF01411(tRNA-synt_2c) | 5 | ALA A 316GLY A 320GLY A 373LEU A 374LEU A 377 | None | 0.97A | 2hw2A-3hxwA:undetectable | 2hw2A-3hxwA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4j | AMINOTRANSFERASE,CLASS III (Deinococcusradiodurans) |
PF00202(Aminotran_3) | 5 | PHE A 22GLY A 404GLY A 332LEU A 333LEU A 336 | None | 1.02A | 2hw2A-3i4jA:undetectable | 2hw2A-3i4jA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ij3 | CYTOSOLAMINOPEPTIDASE (Coxiellaburnetii) |
PF00883(Peptidase_M17) | 5 | ALA A 157GLY A 161ASN A 281GLY A 225LEU A 315 | None | 0.96A | 2hw2A-3ij3A:undetectable | 2hw2A-3ij3A:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kds | CELL DIVISIONPROTEIN FTSH (Thermotogamaritima) |
PF00004(AAA)PF01434(Peptidase_M41) | 5 | ALA E 207GLY E 201GLY E 266LEU E 312LEU E 316 | None | 1.04A | 2hw2A-3kdsE:undetectable | 2hw2A-3kdsE:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzw | CYTOSOLAMINOPEPTIDASE (Staphylococcusaureus) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 5 | PHE A 3ALA A 126MET A 110LEU A 155LEU A 5 | None | 0.94A | 2hw2A-3kzwA:undetectable | 2hw2A-3kzwA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nda | SERPIN-2 (Ixodes ricinus) |
PF00079(Serpin) | 5 | ALA A 40GLY A 42THR A 334SER A 36GLY A 291 | None | 1.09A | 2hw2A-3ndaA:undetectable | 2hw2A-3ndaA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oks | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 5 | ALA A 291GLY A 268GLY A 63LEU A 423LEU A 411 | LLP A 292 ( 2.7A)NoneNoneNoneNone | 0.96A | 2hw2A-3oksA:undetectable | 2hw2A-3oksA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3phf | ENVELOPEGLYCOPROTEIN H (Humangammaherpesvirus4) |
no annotation | 6 | PHE A 322GLY A 302THR A 308GLY A 347LEU A 348LEU A 351 | None | 1.40A | 2hw2A-3phfA:undetectable | 2hw2A-3phfA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pp0 | RECEPTORTYROSINE-PROTEINKINASE ERBB-2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | GLY A 865THR A 759GLY A 787LEU A 785LEU A 712 | NoneNoneNone03Q A 1 (-3.1A)None | 1.07A | 2hw2A-3pp0A:undetectable | 2hw2A-3pp0A:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q8n | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 5 | ALA A 292GLY A 269GLY A 70LEU A 424LEU A 412 | None | 0.98A | 2hw2A-3q8nA:undetectable | 2hw2A-3q8nA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qeq | DMF4 ALPHA CHAIN (Homo sapiens) |
PF07686(V-set)PF09291(DUF1968) | 5 | ALA D 77GLY D 15ASN D 74GLY D 84LEU D 104 | None | 1.03A | 2hw2A-3qeqD:undetectable | 2hw2A-3qeqD:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qp9 | TYPE I POLYKETIDESYNTHASE PIKAII (Streptomycesvenezuelae) |
PF08659(KR) | 5 | PHE A 475ALA A 383GLY A 388LEU A 488LEU A 491 | None | 0.98A | 2hw2A-3qp9A:undetectable | 2hw2A-3qp9A:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4t | 4-AMINOBUTYRATEAMINOTRANSFERASEGABT (Mycobacteriummarinum) |
PF00202(Aminotran_3) | 5 | ALA A 290GLY A 267GLY A 62LEU A 422LEU A 410 | LLP A 291 ( 2.7A)NoneNoneNoneNone | 0.93A | 2hw2A-3r4tA:undetectable | 2hw2A-3r4tA:15.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txy | ISOCHORISMATASEFAMILY PROTEINFAMILY (Burkholderiathailandensis) |
PF00857(Isochorismatase) | 5 | ALA A 131GLY A 135THR A 159GLY A 177LEU A 176 | EDO A 196 ( 3.9A)NoneNoneNoneNone | 1.04A | 2hw2A-3txyA:undetectable | 2hw2A-3txyA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3woz | CLIP-ASSOCIATINGPROTEIN 2 (Mus musculus) |
no annotation | 5 | PHE A 848ALA A 813THR A 773GLY A 862LEU A 866 | None | 1.07A | 2hw2A-3wozA:undetectable | 2hw2A-3wozA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wsb | FARNESYLTRANSFERASE,PUTATIVE (Trypanosomacruzi) |
PF00494(SQS_PSY) | 5 | PHE A 282SER A 42GLY A 174LEU A 175LEU A 178 | NoneFPS A 501 (-2.6A)NoneFPS A 501 (-4.3A)None | 1.08A | 2hw2A-3wsbA:undetectable | 2hw2A-3wsbA:15.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4akr | F-ACTIN-CAPPINGPROTEIN SUBUNITALPHAF-ACTIN-CAPPINGPROTEIN SUBUNIT BETA (Dictyosteliumdiscoideum) |
PF01115(F_actin_cap_B)PF01267(F-actin_cap_A) | 5 | PHE A 48ASN A 13THR A 47LEU B 31LEU B 28 | None | 1.04A | 2hw2A-4akrA:undetectable | 2hw2A-4akrA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atq | 4-AMINOBUTYRATETRANSAMINASE (Paenarthrobacteraurescens) |
PF00202(Aminotran_3) | 5 | ALA A 294GLY A 271GLY A 70LEU A 431LEU A 419 | PLP A1456 ( 4.6A)NoneNoneNoneNone | 1.06A | 2hw2A-4atqA:undetectable | 2hw2A-4atqA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ays | AMYLOSUCRASE (Deinococcusradiodurans) |
PF00128(Alpha-amylase) | 5 | GLY A 490MET A 543GLY A 546LEU A 547LEU A 550 | None | 0.97A | 2hw2A-4aysA:undetectable | 2hw2A-4aysA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e1l | ACETOACETYL-COATHIOLASE 2 (Clostridioidesdifficile) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 186MET A 224GLY A 228LEU A 229LEU A 232 | NoneIOD A 410 ( 4.1A)IOD A 410 ( 4.2A)IOD A 410 ( 4.8A)None | 1.09A | 2hw2A-4e1lA:undetectable | 2hw2A-4e1lA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ffc | 4-AMINOBUTYRATEAMINOTRANSFERASE(GABT) (Mycobacteroidesabscessus) |
PF00202(Aminotran_3) | 5 | ALA A 289GLY A 266GLY A 66LEU A 421LEU A 409 | LLP A 290 ( 2.7A)NoneNoneNoneNone | 1.04A | 2hw2A-4ffcA:undetectable | 2hw2A-4ffcA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4grv | NEUROTENSIN RECEPTORTYPE 1, LYSOZYMECHIMERA (Escherichiavirus T4;Rattusnorvegicus) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 5 | ALA A1160GLY A1162ASN A1002THR A1152GLY A1012 | None | 0.88A | 2hw2A-4grvA:undetectable | 2hw2A-4grvA:13.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h18 | CMT1 (Corynebacteriumglutamicum) |
PF00756(Esterase) | 5 | PHE A 198GLY A 108THR A 194GLY A 156LEU A 155 | None | 1.03A | 2hw2A-4h18A:undetectable | 2hw2A-4h18A:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ij4 | CHITINASE A (Gemmabryumcoronatum) |
PF00182(Glyco_hydro_19) | 5 | PHE A 54GLY A 95GLY A 111LEU A 118LEU A 116 | None | 1.04A | 2hw2A-4ij4A:undetectable | 2hw2A-4ij4A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kl0 | PUTATIVEUNCHARACTERIZEDPROTEIN (Xanthomonasoryzae) |
PF01156(IU_nuc_hydro) | 6 | PHE A 319ALA A 324GLY A 327GLY A 163LEU A 201LEU A 160 | None | 1.38A | 2hw2A-4kl0A:undetectable | 2hw2A-4kl0A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mn8 | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 5 | ALA A 282GLY A 285GLY A 318LEU A 317LEU A 341 | None | 0.99A | 2hw2A-4mn8A:undetectable | 2hw2A-4mn8A:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mna | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 5 | ALA A 282GLY A 285GLY A 318LEU A 317LEU A 341 | None | 1.05A | 2hw2A-4mnaA:undetectable | 2hw2A-4mnaA:12.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mst | CLASS I CHITINASE (Heveabrasiliensis) |
PF00182(Glyco_hydro_19) | 5 | PHE A 110GLY A 163GLY A 179LEU A 186LEU A 184 | None | 1.09A | 2hw2A-4mstA:undetectable | 2hw2A-4mstA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oya | ADENYLATE CYCLASETYPE 10 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | PHE A 348GLY A 434THR A 293SER A 388GLY A 464 | None | 0.92A | 2hw2A-4oyaA:undetectable | 2hw2A-4oyaA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmj | PUTATIVEOXIDOREDUCTASE (Sinorhizobiummeliloti) |
PF00248(Aldo_ket_red) | 5 | PHE A 146ALA A 88GLY A 118THR A 93LEU A 154 | None | 1.08A | 2hw2A-4pmjA:undetectable | 2hw2A-4pmjA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qg5 | PUTATIVEPHOSPHOGLUCOMUTASE (Leishmaniamajor) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | PHE A 39ASN A 133THR A 38GLY A 87LEU A 89 | None | 1.06A | 2hw2A-4qg5A:undetectable | 2hw2A-4qg5A:13.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3k | SPORE GERMINATIONPROTEIN YAAH (Bacillusmegaterium) |
PF00704(Glyco_hydro_18)PF01476(LysM) | 5 | PHE A 277ALA A 405GLY A 157LEU A 156LEU A 153 | None | 1.09A | 2hw2A-4s3kA:undetectable | 2hw2A-4s3kA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uhh | ESTERASE (Thermoguttaterrifontis) |
PF00561(Abhydrolase_1) | 5 | PHE A 168GLY A 219THR A 167GLY A 34LEU A 100 | None | 0.99A | 2hw2A-4uhhA:undetectable | 2hw2A-4uhhA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xe7 | UNCHARACTERIZEDPROTEIN (Bacillusthuringiensis) |
no annotation | 6 | GLY A 238ASN A 235THR A 260GLY A 380LEU A 381LEU A 384 | None | 1.31A | 2hw2A-4xe7A:undetectable | 2hw2A-4xe7A:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zk3 | SERPIN B3 (Homo sapiens) |
PF00079(Serpin) | 6 | ALA A 37GLY A 39THR A 347SER A 33MET A 304GLY A 303 | None | 1.09A | 2hw2A-4zk3A:undetectable | 2hw2A-4zk3A:16.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zn2 | PSLG (Pseudomonasaeruginosa) |
PF00150(Cellulase) | 5 | ALA A 207GLY A 205GLY A 223LEU A 222LEU A 225 | None | 1.07A | 2hw2A-4zn2A:undetectable | 2hw2A-4zn2A:15.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5djq | CBB3-TYPE CYTOCHROMEC OXIDASE SUBUNITCCOP1 (Pseudomonasstutzeri) |
PF13442(Cytochrome_CBB3)PF14715(FixP_N) | 5 | ALA C 106GLY C 111GLY C 135LEU C 293LEU C 294 | NoneNoneNoneNoneHEC C 402 ( 4.1A) | 1.04A | 2hw2A-5djqC:undetectable | 2hw2A-5djqC:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e2h | BETA-LACTAMASE (Mycolicibacteriumsmegmatis) |
PF00144(Beta-lactamase) | 5 | ALA A 215GLY A 217MET A 168LEU A 173LEU A 176 | None | 0.90A | 2hw2A-5e2hA:undetectable | 2hw2A-5e2hA:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e38 | URACILPHOSPHORIBOSYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF14681(UPRTase) | 5 | ALA A 133GLY A 164GLY A 143LEU A 142LEU A 145 | None | 1.00A | 2hw2A-5e38A:undetectable | 2hw2A-5e38A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epa | SNOK (Streptomycesnogalater) |
PF05721(PhyH) | 5 | GLY A 126ASN A 130THR A 135LEU A 244LEU A 247 | None | 1.04A | 2hw2A-5epaA:undetectable | 2hw2A-5epaA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evl | BETA-LACTAMASE (Chromobacteriumviolaceum) |
PF00144(Beta-lactamase) | 5 | ALA A 222GLY A 224MET A 175LEU A 180LEU A 183 | None | 0.96A | 2hw2A-5evlA:undetectable | 2hw2A-5evlA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fn4 | NICASTRIN (Homo sapiens) |
PF05450(Nicastrin) | 5 | ALA A 572GLY A 576GLY A 495LEU A 312LEU A 498 | None | 1.01A | 2hw2A-5fn4A:undetectable | 2hw2A-5fn4A:11.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gp4 | GLUTAMATEDECARBOXYLASE (Lactobacillusbrevis) |
no annotation | 5 | ALA C 248GLY C 251SER C 126LEU C 223LEU C 226 | PLP C 501 (-3.1A)NonePLP C 501 (-4.2A)NoneNone | 1.09A | 2hw2A-5gp4C:undetectable | 2hw2A-5gp4C:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gr8 | LEUCINE-RICH REPEATRECEPTOR-LIKEPROTEIN KINASE PEPR1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | GLY A 251ASN A 321GLY A 282LEU A 303LEU A 327 | NAG A 803 ( 3.9A)NoneSO4 A 807 (-3.9A)NoneNone | 1.08A | 2hw2A-5gr8A:undetectable | 2hw2A-5gr8A:12.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3h | ABHYDROLASEDOMAIN-CONTAININGPROTEIN (Exiguobacteriumantarcticum) |
PF00561(Abhydrolase_1)PF08386(Abhydrolase_4) | 5 | ALA A 64GLY A 188ASN A 33MET A 74LEU A 27 | None | 0.99A | 2hw2A-5h3hA:undetectable | 2hw2A-5h3hA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hz1 | PROBABLE LRRRECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASEAT4G26540 (Arabidopsisthaliana) |
PF13855(LRR_8) | 5 | GLY B 228THR B 224SER B 248GLY B 211LEU B 237 | None | 1.00A | 2hw2A-5hz1B:undetectable | 2hw2A-5hz1B:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5inw | PUTATIVEANGIOTENSINOGEN (Lampetrafluviatilis) |
PF00079(Serpin) | 5 | ALA A 115GLY A 117THR A 411MET A 368GLY A 367 | None | 0.88A | 2hw2A-5inwA:undetectable | 2hw2A-5inwA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j7z | PUTATIVE SECRETEDENDOGLYCOSYLCERAMIDASE (Rhodococcushoagii) |
PF00150(Cellulase) | 5 | ALA A 118GLY A 114ASN A 58GLY A 208LEU A 128 | None | 0.97A | 2hw2A-5j7zA:undetectable | 2hw2A-5j7zA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrw | POTASSIUM-TRANSPORTING ATPASEATP-BINDING SUBUNITPOTASSIUM-TRANSPORTING ATPASEPOTASSIUM-BINDINGSUBUNIT (Escherichiacoli) |
PF00122(E1-E2_ATPase)PF00702(Hydrolase)PF03814(KdpA) | 5 | PHE B 232PHE A 392ALA B 227GLY B 573LEU A 396 | None | 1.09A | 2hw2A-5mrwB:undetectable | 2hw2A-5mrwB:12.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4a | INTRAFLAGELLARTRANSPORT PROTEIN 80 (Chlamydomonasreinhardtii) |
no annotation | 5 | GLY A 204SER A 223GLY A 285LEU A 274LEU A 283 | None | 0.85A | 2hw2A-5n4aA:undetectable | 2hw2A-5n4aA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9m | COBYRIC ACIDSYNTHASE (Staphylococcusaureus) |
no annotation | 5 | GLY A 21ASN A 196GLY A 90LEU A 91LEU A 184 | None | 0.92A | 2hw2A-5n9mA:undetectable | 2hw2A-5n9mA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vc2 | SERINEHYDROXYMETHYLTRANSFERASE (Helicobacterpylori) |
PF00464(SHMT) | 5 | ALA A 335GLY A 333MET A 29GLY A 360LEU A 314 | None | 1.07A | 2hw2A-5vc2A:undetectable | 2hw2A-5vc2A:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xks | THERMOSTABLEMONOACYLGLYCEROLLIPASE (Geobacillus sp.12AMOR1) |
no annotation | 5 | ALA A 117GLY A 115SER A 241GLY A 80LEU A 84 | None | 0.97A | 2hw2A-5xksA:undetectable | 2hw2A-5xksA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5za2 | BETA-LACTAMASE (Escherichiacoli) |
no annotation | 5 | ALA A 221GLY A 223MET A 174LEU A 179LEU A 182 | None | 0.99A | 2hw2A-5za2A:undetectable | 2hw2A-5za2A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c01 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 3 (Homo sapiens) |
no annotation | 5 | ALA A 498GLY A 500MET A 353GLY A 355LEU A 356 | None | 1.00A | 2hw2A-6c01A:undetectable | 2hw2A-6c01A:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cxd | PEPTIDASE B (Yersinia pestis) |
no annotation | 5 | ALA A 119GLY A 123ASN A 251GLY A 195LEU A 285 | None | 0.99A | 2hw2A-6cxdA:undetectable | 2hw2A-6cxdA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dft | - (-) |
no annotation | 5 | ALA B 99GLY B 214THR B 97GLY B 134LEU B 136 | NAD B 500 (-3.2A)NAD B 500 (-3.6A)NoneNoneNone | 1.07A | 2hw2A-6dftB:undetectable | 2hw2A-6dftB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ekv | TOXIN COMPLEXCOMPONENT ORF-X2 (Clostridiumbotulinum) |
no annotation | 5 | PHE A 7GLY A 63GLY A 174LEU A 173LEU A 172 | None | 1.05A | 2hw2A-6ekvA:undetectable | 2hw2A-6ekvA:12.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f2t | - (-) |
no annotation | 5 | ALA A 498GLY A 500MET A 354GLY A 356LEU A 357 | None | 0.98A | 2hw2A-6f2tA:undetectable | 2hw2A-6f2tA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fm7 | BETA-LACTAMASE (Aeromonasenteropelogenes) |
no annotation | 5 | ALA A 219GLY A 221MET A 172LEU A 177LEU A 180 | None | 1.00A | 2hw2A-6fm7A:undetectable | 2hw2A-6fm7A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fxn | BELIMUMAB HEAVYCHAIN (Homo sapiens) |
no annotation | 5 | ALA D 72GLY D 77ASN D 32GLY D 114LEU D 4 | None | 1.09A | 2hw2A-6fxnD:undetectable | 2hw2A-6fxnD:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gct | NEUTRAL AMINO ACIDTRANSPORTER B(0) (Homo sapiens) |
no annotation | 5 | ALA A 429GLY A 434THR A 384MET A 267LEU A 107 | GLN A 601 (-4.5A)GLN A 601 ( 4.8A)NoneNoneNone | 1.08A | 2hw2A-6gctA:undetectable | 2hw2A-6gctA:21.68 |