SIMILAR PATTERNS OF AMINO ACIDS FOR 2HS1_B_017B203

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ash HEMOGLOBIN (OXY)

(Ascaris suum) 		PF00042
(Globin) 		4 PRO A  59
LYS A  63
ARG A  23
GLY A  26
 None
 1.28A 2hs1B-1ashA:
undetectable		 2hs1B-1ashA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN

(Escherichia
coli) 		PF12804
(NTP_transf_3) 		4 GLU A 129
PRO A 133
ARG A 130
GLY A 128
 None
 1.30A 2hs1B-1fr9A:
undetectable		 2hs1B-1fr9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5y HISF

(Pyrobaculum
aerophilum) 		PF00977
(His_biosynth) 		4 GLU A 164
TRP A 159
PRO A 113
GLY A 167
 None
 1.08A 2hs1B-1h5yA:
undetectable		 2hs1B-1h5yA:
14.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
MET A  46
ARG A  57
 None
 0.79A 2hs1B-1hvcA:
14.0		 2hs1B-1hvcA:
46.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
MET A  46
GLY A  78
 None
 0.64A 2hs1B-1hvcA:
14.0		 2hs1B-1hvcA:
46.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 TRP A  42
PRO A  44
MET A  46
LYS A  55
ARG A  57
 None
 1.15A 2hs1B-1hvcA:
14.0		 2hs1B-1hvcA:
46.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 TRP A  42
PRO A  44
MET A  46
LYS A  55
GLY A  78
 None
 0.62A 2hs1B-1hvcA:
14.0		 2hs1B-1hvcA:
46.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1g SF1-BO ISOFORM

(Homo sapiens) 		PF00013
(KH_1) 		4 GLU A 149
PRO A 197
MET A 195
GLY A 186
 A  B 507 ( 4.7A)
None
A  B 510 ( 4.3A)
None
 1.06A 2hs1B-1k1gA:
undetectable		 2hs1B-1k1gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 TRP A  11
PRO A 356
MET A 362
ARG A 353
GLY A 365
 CL  A 801 (-4.4A)
None
None
None
None
 1.46A 2hs1B-1kwgA:
undetectable		 2hs1B-1kwgA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 GLU A 343
TRP A 336
ARG A  12
GLY A  14
 None
 1.29A 2hs1B-1lwhA:
undetectable		 2hs1B-1lwhA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLU A  36
PRO A 204
ARG A 203
GLY A  37
 None
 1.26A 2hs1B-1ofuA:
undetectable		 2hs1B-1ofuA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q9p HIV-1 PROTEASE

(Homo sapiens) 		PF00077
(RVP) 		4 PRO A  44
MET A  46
ARG A  57
GLY A  78
 None
 0.91A 2hs1B-1q9pA:
10.1		 2hs1B-1q9pA:
98.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv SEROTRANSFERRIN,
C-LOBE
TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF00405
(Transferrin)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 GLU A 759
PRO E 505
ARG E 508
GLY E 499
 None
 1.28A 2hs1B-1suvA:
undetectable		 2hs1B-1suvA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		4 GLU A   8
TRP A  65
MET A 263
GLY A  26
 None
 1.26A 2hs1B-1t8hA:
undetectable		 2hs1B-1t8hA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		4 GLU A 713
TRP A 706
MET A 747
GLY A 714
 None
 1.28A 2hs1B-1taqA:
undetectable		 2hs1B-1taqA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tiq PROTEASE SYNTHASE
AND SPORULATION
NEGATIVE REGULATORY
PROTEIN PAI 1

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		4 GLU A 160
PRO A  34
MET A  37
GLY A 158
 None
None
DTT  A1201 (-4.3A)
DTT  A1201 (-3.7A)
 1.16A 2hs1B-1tiqA:
undetectable		 2hs1B-1tiqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		4 GLU A  87
PRO A  35
ARG A  37
GLY A 224
 None
 1.24A 2hs1B-1wmwA:
undetectable		 2hs1B-1wmwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		4 GLU A 130
PRO A 194
MET A 197
GLY A 132
 None
 1.23A 2hs1B-2cu2A:
undetectable		 2hs1B-2cu2A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		4 GLU A 229
PRO A 140
LYS A 146
GLY A 156
 SO4  A 503 ( 2.7A)
None
None
None
 1.15A 2hs1B-2eg3A:
undetectable		 2hs1B-2eg3A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 GLU A 198
PRO A 173
LYS A 189
GLY A 199
 None
 1.13A 2hs1B-2i80A:
undetectable		 2hs1B-2i80A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00977
(His_biosynth) 		4 GLU A 140
TRP A 135
PRO A  89
GLY A 143
 None
 1.22A 2hs1B-2lleA:
undetectable		 2hs1B-2lleA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLU A 126
PRO A 111
LYS A 903
GLY A 101
 None
 1.20A 2hs1B-2qo3A:
undetectable		 2hs1B-2qo3A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLU A  86
PRO A  60
ARG A  61
GLY A  84
 None
 0.82A 2hs1B-2r0lA:
undetectable		 2hs1B-2r0lA:
12.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
LYS A  55
GLY A  78
 None
 0.40A 2hs1B-2rkfA:
20.6		 2hs1B-2rkfA:
83.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x06 L-SULFOLACTATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF02615
(Ldh_2) 		4 GLU A 215
PRO A 206
LYS A 150
GLY A 216
 None
 1.30A 2hs1B-2x06A:
undetectable		 2hs1B-2x06A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3

(Homo sapiens) 		PF01026
(TatD_DNase) 		4 GLU A 225
TRP A 233
PRO A 232
GLY A 223
 None
 1.30A 2hs1B-2y1hA:
undetectable		 2hs1B-2y1hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yf0 MYOTUBULARIN-RELATED
PROTEIN 6

(Homo sapiens) 		PF06602
(Myotub-related) 		4 GLU A 381
PRO A 395
ARG A 382
GLY A 384
 None
 1.13A 2hs1B-2yf0A:
undetectable		 2hs1B-2yf0A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzy PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1012

(Thermus
thermophilus) 		no annotation 4 GLU A 161
PRO A 140
MET A 143
ARG A 173
 MPD  A 502 (-3.5A)
None
None
None
 1.19A 2hs1B-2yzyA:
undetectable		 2hs1B-2yzyA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLU B 212
TRP B 214
PRO A 239
GLY B 218
 None
 0.91A 2hs1B-3ayxB:
undetectable		 2hs1B-3ayxB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 GLU A 726
PRO A 536
ARG A 707
GLY A 708
 None
 1.12A 2hs1B-3bdlA:
undetectable		 2hs1B-3bdlA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		4 GLU A 330
TRP A 122
PRO A 121
GLY A 331
 None
 1.30A 2hs1B-3bxhA:
undetectable		 2hs1B-3bxhA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		4 GLU A 424
PRO A 318
ARG A 443
GLY A 446
 None
 1.31A 2hs1B-3d3aA:
undetectable		 2hs1B-3d3aA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3j ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N)
PF09532
(FDF) 		4 GLU A 469
PRO A 445
LYS A 453
GLY A 472
 None
 1.24A 2hs1B-3d3jA:
undetectable		 2hs1B-3d3jA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 GLU A  49
PRO A 393
ARG A 395
GLY A  51
 None
 1.31A 2hs1B-3g77A:
undetectable		 2hs1B-3g77A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 GLU A 164
PRO A 190
ARG A 165
GLY A 168
 NAG  A 624 ( 4.1A)
None
None
None
 1.22A 2hs1B-3h55A:
undetectable		 2hs1B-3h55A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		4 GLU A 335
PRO A  81
ARG A  80
GLY A 333
 None
 1.21A 2hs1B-3hutA:
undetectable		 2hs1B-3hutA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 GLU A1313
PRO A1733
ARG A1306
GLY A1311
 None
 1.26A 2hs1B-3ig3A:
undetectable		 2hs1B-3ig3A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 GLU B 218
PRO B 255
ARG B 219
GLY B 220
 None
 1.26A 2hs1B-3igzB:
undetectable		 2hs1B-3igzB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 GLU B 681
MET B 620
ARG B 682
GLY B 680
 None
 1.27A 2hs1B-3k70B:
undetectable		 2hs1B-3k70B:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		4 GLU A  73
PRO A 227
ARG A 229
GLY A  72
 None
 1.21A 2hs1B-3muqA:
undetectable		 2hs1B-3muqA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 TRP A  42
PRO A  44
MET A  46
ARG A  57
GLY A  78
 None
 0.34A 2hs1B-3mwsA:
20.0		 2hs1B-3mwsA:
78.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzi ACTIVATOR OF
PHOTOPIGMENT AND PUC
EXPRESSION

(Synechocystis
sp. PCC 6803) 		PF04940
(BLUF) 		4 GLU A  55
PRO A  33
MET A  93
GLY A  54
 None
None
FMN  A 154 ( 4.7A)
None
 1.10A 2hs1B-3mziA:
undetectable		 2hs1B-3mziA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 GLU A  94
PRO A 142
ARG A 108
GLY A 105
 None
 1.30A 2hs1B-3n05A:
undetectable		 2hs1B-3n05A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 GLU A 217
PRO A 254
ARG A 218
GLY A 219
 None
 1.24A 2hs1B-3nvlA:
undetectable		 2hs1B-3nvlA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF06050
(HGD-D) 		4 GLU A  95
PRO A 107
MET A 104
GLY A  97
 None
 1.29A 2hs1B-3o3oA:
undetectable		 2hs1B-3o3oA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 GLU A 370
PRO A 374
ARG A 373
GLY A 339
 None
GOL  A 500 ( 4.7A)
None
None
 0.98A 2hs1B-3oepA:
undetectable		 2hs1B-3oepA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK)
no annotation 		4 GLU B 930
TRP I 328
PRO I 297
ARG I 301
 None
 1.13A 2hs1B-3opyB:
undetectable		 2hs1B-3opyB:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 GLU A 454
PRO A 499
ARG A 500
GLY A 452
 None
 0.91A 2hs1B-3pihA:
undetectable		 2hs1B-3pihA:
8.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 PRO A  44
MET A  46
ARG A  57
GLY A  78
 None
 0.79A 2hs1B-3t3cA:
18.4		 2hs1B-3t3cA:
73.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
ARG A  57
GLY A  78
 None
 0.49A 2hs1B-3t3cA:
18.4		 2hs1B-3t3cA:
73.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		4 GLU B 864
PRO B 856
ARG B 854
GLY B 863
 None
 1.16A 2hs1B-3thwB:
undetectable		 2hs1B-3thwB:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 GLU A 128
PRO A  82
LYS A 188
GLY A 125
 None
 1.29A 2hs1B-3ti8A:
undetectable		 2hs1B-3ti8A:
14.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 PRO A  44
MET A  46
LYS A  55
ARG A  57
 None
 1.03A 2hs1B-3ttpA:
19.5		 2hs1B-3ttpA:
77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 TRP A  42
PRO A  44
MET A  46
LYS A  55
GLY A  78
 None
 0.55A 2hs1B-3ttpA:
19.5		 2hs1B-3ttpA:
77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uhl PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
ARG A  57
GLY A  78
 None
 0.46A 2hs1B-3uhlA:
16.1		 2hs1B-3uhlA:
81.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn3 ANTIFREEZE PROTEIN

(Typhula
ishikariensis) 		PF11999
(DUF3494) 		4 GLU A 186
TRP A 142
LYS A 167
GLY A 187
 None
 1.21A 2hs1B-3vn3A:
undetectable		 2hs1B-3vn3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		4 GLU A  60
PRO A 760
LYS A 762
GLY A 121
 None
 1.22A 2hs1B-4anjA:
undetectable		 2hs1B-4anjA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 GLU A 212
PRO A 161
ARG A 215
GLY A 210
 None
 1.28A 2hs1B-4apbA:
undetectable		 2hs1B-4apbA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdb LISTERIOLYSIN O

(Listeria
monocytogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 GLU A 443
PRO A  87
LYS A  90
GLY A 444
 None
 1.31A 2hs1B-4cdbA:
undetectable		 2hs1B-4cdbA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		4 GLU A 128
PRO A  57
ARG A 125
GLY A 126
 None
 1.02A 2hs1B-4dmgA:
undetectable		 2hs1B-4dmgA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 GLU A 360
TRP A 134
PRO A 118
ARG A 340
 None
 1.30A 2hs1B-4eyoA:
undetectable		 2hs1B-4eyoA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gj4 SOLUBLE GUANYLYL
CYCLASE ALPHA-1
SUBUNIT

(Manduca sexta) 		PF07701
(HNOBA) 		4 PRO A 348
MET A 350
LYS A 368
GLY A 384
 None
 0.80A 2hs1B-4gj4A:
undetectable		 2hs1B-4gj4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		4 GLU A 253
TRP A 252
LYS A 291
GLY A 243
 None
 1.09A 2hs1B-4gm6A:
undetectable		 2hs1B-4gm6A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLU A 113
PRO A  51
LYS A  97
GLY A 109
 None
 1.18A 2hs1B-4hjlA:
undetectable		 2hs1B-4hjlA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		4 GLU A 402
PRO A  88
ARG A  89
GLY A 405
 None
 1.27A 2hs1B-4iv9A:
undetectable		 2hs1B-4iv9A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		4 GLU A  65
TRP A  60
PRO A  14
GLY A  68
 None
 1.28A 2hs1B-4j9jA:
undetectable		 2hs1B-4j9jA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		4 GLU A 186
TRP A 181
PRO A 135
GLY A 189
 None
 1.19A 2hs1B-4j9jA:
undetectable		 2hs1B-4j9jA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 GLU A  55
PRO A 157
MET A  16
GLY A  56
 PQQ  A 602 (-2.5A)
None
None
None
 1.21A 2hs1B-4maeA:
undetectable		 2hs1B-4maeA:
10.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
MET A  46
GLY A  78
 None
 0.59A 2hs1B-4njvA:
20.3		 2hs1B-4njvA:
83.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu3 ICE-BINDING PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		4 GLU A 218
TRP A 174
LYS A 199
GLY A 219
 None
 1.29A 2hs1B-4nu3A:
undetectable		 2hs1B-4nu3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		4 GLU A 292
PRO A 284
ARG A 287
GLY A 290
 None
 1.24A 2hs1B-4nwzA:
undetectable		 2hs1B-4nwzA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 4 GLU B  83
PRO B 190
MET B  44
GLY B  84
 PQQ  B 702 (-2.9A)
None
None
None
 1.26A 2hs1B-4tqoB:
undetectable		 2hs1B-4tqoB:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyz UNCHARACTERIZED
PROTEIN

(Leishmania
infantum) 		PF02893
(GRAM) 		4 GLU A 623
PRO A 631
ARG A 627
GLY A 624
 None
 1.31A 2hs1B-4tyzA:
undetectable		 2hs1B-4tyzA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b18 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
LYS A  55
GLY A  78
 None
 0.70A 2hs1B-5b18A:
17.9		 2hs1B-5b18A:
74.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5h ANTIFREEZE PROTEIN

(Typhula
ishikariensis) 		PF11999
(DUF3494) 		4 GLU A 186
TRP A 142
LYS A 167
GLY A 187
 None
 1.29A 2hs1B-5b5hA:
undetectable		 2hs1B-5b5hA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLU A 440
PRO A 464
MET A 462
GLY A 509
 None
 1.21A 2hs1B-5dotA:
undetectable		 2hs1B-5dotA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 PRO A 347
MET A 345
ARG A 349
GLY A 342
 None
 1.19A 2hs1B-5h7kA:
undetectable		 2hs1B-5h7kA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		4 GLU A  51
TRP A  58
ARG A  49
GLY A 193
 None
 1.21A 2hs1B-5i0pA:
undetectable		 2hs1B-5i0pA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		4 GLU A 405
PRO A 489
MET A 485
GLY A 509
 None
 1.00A 2hs1B-5i35A:
undetectable		 2hs1B-5i35A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLU B1132
MET B1152
ARG B1135
GLY A 342
 None
 0.91A 2hs1B-5ip9B:
undetectable		 2hs1B-5ip9B:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 GLU A  74
TRP A  41
PRO A  43
GLY A  84
 None
 1.14A 2hs1B-5jodA:
7.1		 2hs1B-5jodA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 GLU A 365
PRO A 237
ARG A 239
GLY A 242
 None
 1.12A 2hs1B-5kufA:
undetectable		 2hs1B-5kufA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkn NEURAL CELL ADHESION
MOLECULE 1

(Homo sapiens) 		PF00041
(fn3) 		4 GLU A 676
MET A 595
ARG A 632
GLY A 680
 None
 0.88A 2hs1B-5lknA:
undetectable		 2hs1B-5lknA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
ARG A  57
GLY A  78
 None
 0.29A 2hs1B-5t2zA:
20.2		 2hs1B-5t2zA:
79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 TRP A  42
PRO A  44
LYS A  55
ARG A  57
 None
 0.67A 2hs1B-5t2zA:
20.2		 2hs1B-5t2zA:
79.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 120
MET A 201
ARG A 133
GLY A 214
 None
 1.15A 2hs1B-5u2aA:
undetectable		 2hs1B-5u2aA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7i PALMITOYLTRANSFERASE
ZDHHC17

(Homo sapiens) 		PF12796
(Ank_2) 		4 GLU A 156
PRO A 193
MET A 186
GLY A 157
 None
 1.29A 2hs1B-5w7iA:
undetectable		 2hs1B-5w7iA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E

(Leishmania
major) 		no annotation 4 GLU A  77
PRO A  86
MET A  82
LYS A  80
 None
 1.23A 2hs1B-5wb5A:
undetectable		 2hs1B-5wb5A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 4 GLU A 421
TRP A 383
PRO A 388
GLY A 425
 None
 1.15A 2hs1B-5wzkA:
undetectable		 2hs1B-5wzkA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 4 GLU A 211
PRO A 219
ARG A 210
GLY A 212
 None
 1.20A 2hs1B-5x7uA:
undetectable		 2hs1B-5x7uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLU B1132
MET B1152
ARG B1135
GLY A 343
 None
 0.96A 2hs1B-5xogB:
undetectable		 2hs1B-5xogB:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yep TOXIN-ANTITOXIN
SYSTEM ANTIDOTE MNT
FAMILY
TOXIN-ANTITOXIN
SYSTEM TOXIN HEPN
FAMILY

(Shewanella
oneidensis) 		no annotation 4 GLU A 101
MET A 110
LYS A 106
ARG B  59
 None
 1.20A 2hs1B-5yepA:
undetectable		 2hs1B-5yepA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM

(Geobacillus
stearothermophilus) 		no annotation 4 GLU A 154
TRP A  87
MET A   1
GLY A 156
 None
 1.25A 2hs1B-5yhhA:
undetectable		 2hs1B-5yhhA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yid PLASMEPSIN II

(Plasmodium
falciparum) 		no annotation 4 GLU A  76
TRP A  43
PRO A  45
GLY A  86
 None
 1.12A 2hs1B-5yidA:
6.7		 2hs1B-5yidA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 4 GLU A  79
MET A 109
ARG A 118
GLY A  80
 None
 1.09A 2hs1B-5yvsA:
undetectable		 2hs1B-5yvsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywp JEV E PROTEIN

(Japanese
encephalitis
virus) 		no annotation 4 TRP A 225
PRO A 227
ARG A  57
GLY A 127
 None
 0.97A 2hs1B-5ywpA:
undetectable		 2hs1B-5ywpA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 4 GLU A1776
PRO A1914
ARG A1913
GLY A1805
 None
 1.14A 2hs1B-5yz0A:
undetectable		 2hs1B-5yz0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 GLU A  85
PRO A  38
ARG A  39
GLY A  67
 None
 1.26A 2hs1B-6aqhA:
undetectable		 2hs1B-6aqhA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4n PSEUDOPALINE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 4 GLU A 352
PRO A 411
ARG A 357
GLY A 354
 None
 1.28A 2hs1B-6c4nA:
undetectable		 2hs1B-6c4nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g43 PUTATIVE MAJOR
CAPSID PROTEIN

(Cafeteriavirus-dependent
mavirus) 		no annotation 4 GLU A 164
MET A 170
ARG A 160
GLY A 162
 None
 1.25A 2hs1B-6g43A:
undetectable		 2hs1B-6g43A:
17.71