SIMILAR PATTERNS OF AMINO ACIDS FOR 2HRE_D_CHDD702

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		3 ARG A 154
GLY A 122
PRO A 123
 None
 0.66A 2hreD-1ee8A:
0.0		 2hreD-1ee8A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ARG A 639
GLY A 630
PRO A 631
 None
 0.73A 2hreD-1h17A:
0.0		 2hreD-1h17A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im9 KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DL1

(Homo sapiens) 		PF00047
(ig) 		3 ARG D 148
GLY D 167
PRO D 168
 None
 0.72A 2hreD-1im9D:
0.0		 2hreD-1im9D:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqp RFCS

(Pyrococcus
furiosus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 ARG A 165
GLY A  53
PRO A  54
 None
 0.58A 2hreD-1iqpA:
0.0		 2hreD-1iqpA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		3 ARG A 102
GLY A 188
PRO A 189
 None
 0.68A 2hreD-1itkA:
0.0		 2hreD-1itkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 ARG A 381
GLY A 399
PRO A 400
 None
 0.69A 2hreD-1n5xA:
0.0		 2hreD-1n5xA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE

(Mycobacterium
tuberculosis) 		PF02548
(Pantoate_transf) 		3 ARG A 137
GLY A 110
PRO A 111
 None
 0.77A 2hreD-1oy0A:
0.0		 2hreD-1oy0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r45 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
phage c-st) 		PF03496
(ADPrib_exo_Tox) 		3 ARG A 167
GLY A 136
PRO A 137
 SO4  A1003 (-4.0A)
None
None
 0.75A 2hreD-1r45A:
0.0		 2hreD-1r45A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 ARG A1010
GLY A1250
PRO A1249
 NAP  A1453 (-2.9A)
NAP  A1453 (-3.6A)
NAP  A1453 (-4.2A)
 0.70A 2hreD-1tllA:
0.9		 2hreD-1tllA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ARG A 366
GLY A 280
PRO A 281
 None
 0.68A 2hreD-1uliA:
undetectable		 2hreD-1uliA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		3 ARG A 316
GLY A 243
PRO A 244
 ARG  A 316 ( 0.6A)
GLY  A 243 ( 0.0A)
PRO  A 244 ( 1.1A)
 0.70A 2hreD-1vhoA:
2.4		 2hreD-1vhoA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		3 ARG A 206
GLY A 225
PRO A 226
 None
 0.60A 2hreD-1y3tA:
undetectable		 2hreD-1y3tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		3 ARG A 325
GLY A 355
PRO A 356
 None
 0.74A 2hreD-2b8nA:
undetectable		 2hreD-2b8nA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		3 ARG A 213
GLY A 190
PRO A 191
 NAP  A1367 (-3.9A)
NAP  A1367 ( 4.3A)
NAP  A1367 (-3.6A)
 0.73A 2hreD-2cdaA:
undetectable		 2hreD-2cdaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chq REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 ARG A 157
GLY A  45
PRO A  46
 None
 0.76A 2hreD-2chqA:
undetectable		 2hreD-2chqA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crb NUCLEAR RECEPTOR
BINDING FACTOR 2

(Mus musculus) 		PF17169
(NRBF2_MIT) 		3 ARG A  87
GLY A  93
PRO A  94
 None
 0.58A 2hreD-2crbA:
undetectable		 2hreD-2crbA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		3 ARG A 266
GLY A 241
PRO A 240
 None
 0.77A 2hreD-2ctzA:
undetectable		 2hreD-2ctzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuh TENASCIN-X

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A  80
GLY A  10
PRO A  11
 None
 0.74A 2hreD-2cuhA:
undetectable		 2hreD-2cuhA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		3 ARG A 246
GLY A 249
PRO A 250
 None
 0.73A 2hreD-2fefA:
undetectable		 2hreD-2fefA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		3 ARG A 108
GLY A 348
PRO A 349
 None
 0.76A 2hreD-2hufA:
undetectable		 2hreD-2hufA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF07313
(DUF1460) 		3 ARG A 145
GLY A 100
PRO A 101
 None
 0.55A 2hreD-2im9A:
undetectable		 2hreD-2im9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF07995
(GSDH) 		3 ARG A 139
GLY A 271
PRO A 270
 None
 0.74A 2hreD-2ismA:
undetectable		 2hreD-2ismA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jd4 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		3 ARG A2869
GLY A2693
PRO A2692
 None
 0.70A 2hreD-2jd4A:
undetectable		 2hreD-2jd4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		3 ARG A 229
GLY A 148
PRO A 149
 None
 0.49A 2hreD-2p35A:
undetectable		 2hreD-2p35A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		3 ARG A 334
GLY A 324
PRO A 325
 None
 0.64A 2hreD-2q6tA:
undetectable		 2hreD-2q6tA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd3 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Methanothermobacter
thermautotrophicus) 		PF01634
(HisG)
PF08029
(HisG_C) 		3 ARG A 172
GLY A 106
PRO A 107
 None
 0.51A 2hreD-2vd3A:
undetectable		 2hreD-2vd3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 3 ARG A 206
GLY A  15
PRO A  16
 PO4  A1244 (-3.6A)
None
None
 0.71A 2hreD-2wjfA:
undetectable		 2hreD-2wjfA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		3 ARG A 340
GLY A 372
PRO A 373
 None
 0.72A 2hreD-2wzgA:
undetectable		 2hreD-2wzgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		3 ARG A 323
GLY A  94
PRO A  95
 None
 0.59A 2hreD-2xijA:
2.4		 2hreD-2xijA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		3 ARG A 112
GLY A 194
PRO A 195
 None
 0.60A 2hreD-2xwgA:
undetectable		 2hreD-2xwgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE

(Aspergillus
fumigatus) 		PF13088
(BNR_2) 		3 ARG A 262
GLY A 206
PRO A 207
 None
 0.77A 2hreD-2xziA:
undetectable		 2hreD-2xziA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zg3 SIALIC ACID-BINDING
IG-LIKE LECTIN 5

(Homo sapiens) 		PF07686
(V-set) 		3 ARG A  96
GLY A 178
PRO A 179
 None
 0.65A 2hreD-2zg3A:
undetectable		 2hreD-2zg3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		3 ARG A 318
GLY A 454
PRO A 455
 None
 0.75A 2hreD-3b2zA:
2.3		 2hreD-3b2zA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw8 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Hathewaya
limosa) 		PF03496
(ADPrib_exo_Tox) 		3 ARG A 127
GLY A  96
PRO A  97
 None
 0.64A 2hreD-3bw8A:
undetectable		 2hreD-3bw8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzj UV ENDONUCLEASE

(Thermus
thermophilus) 		PF03851
(UvdE) 		3 ARG A 227
GLY A 262
PRO A 261
 None
 0.70A 2hreD-3bzjA:
undetectable		 2hreD-3bzjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ARG A 471
GLY A 151
PRO A 152
 None
 0.58A 2hreD-3cghA:
undetectable		 2hreD-3cghA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		3 ARG A 151
GLY A 153
PRO A 154
 None
 0.60A 2hreD-3cm5A:
undetectable		 2hreD-3cm5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A 329
GLY A 352
PRO A 353
 None
 0.77A 2hreD-3dhvA:
2.1		 2hreD-3dhvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		3 ARG A 110
GLY A 119
PRO A 120
 None
 0.55A 2hreD-3e4eA:
undetectable		 2hreD-3e4eA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ARG A 364
GLY A 278
PRO A 279
 None
 0.69A 2hreD-3eqqA:
undetectable		 2hreD-3eqqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2

(Homo sapiens) 		PF01852
(START) 		3 ARG A 523
GLY A 553
PRO A 552
 None
None
GOL  A 595 ( 4.8A)
 0.63A 2hreD-3fo5A:
undetectable		 2hreD-3fo5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		3 ARG A 470
GLY A 168
PRO A 169
 None
None
ACT  A  13 (-4.0A)
 0.67A 2hreD-3gzsA:
undetectable		 2hreD-3gzsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ARG A 374
GLY A 289
PRO A 290
 None
 0.52A 2hreD-3gzyA:
undetectable		 2hreD-3gzyA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ARG A1055
GLY A 644
PRO A 645
 None
 0.33A 2hreD-3h0gA:
undetectable		 2hreD-3h0gA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		3 ARG A 414
GLY A 397
PRO A 398
 None
 0.65A 2hreD-3iibA:
undetectable		 2hreD-3iibA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		3 ARG A 373
GLY A 481
PRO A 482
 SO4  A 592 (-3.0A)
None
None
 0.77A 2hreD-3l5hA:
undetectable		 2hreD-3l5hA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3w PROTEIN KINASE C AND
CASEIN KINASE II
SUBSTRATE PROTEIN 3

(Mus musculus) 		PF00611
(FCH) 		3 ARG A  99
GLY A 104
PRO A 105
 None
 0.73A 2hreD-3m3wA:
undetectable		 2hreD-3m3wA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1

(Necator
americanus) 		PF00188
(CAP) 		3 ARG A 351
GLY A 339
PRO A 340
 None
 0.68A 2hreD-3nt8A:
undetectable		 2hreD-3nt8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2k BREVIANAMIDE F
PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		3 ARG A 134
GLY A  74
PRO A  75
 None
 0.56A 2hreD-3o2kA:
undetectable		 2hreD-3o2kA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		3 ARG A  19
GLY A 192
PRO A 191
 None
 0.77A 2hreD-3oepA:
undetectable		 2hreD-3oepA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		3 ARG A 414
GLY A 427
PRO A 428
 GOL  A 502 (-3.5A)
None
None
 0.59A 2hreD-3oepA:
undetectable		 2hreD-3oepA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olm E3 UBIQUITIN-PROTEIN
LIGASE RSP5

(Saccharomyces
cerevisiae) 		PF00397
(WW)
PF00632
(HECT) 		3 ARG A 483
GLY A 756
PRO A 757
 None
 0.70A 2hreD-3olmA:
undetectable		 2hreD-3olmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis) 		PF12741
(SusD-like) 		3 ARG A 473
GLY A 145
PRO A 146
 None
 0.42A 2hreD-3p1uA:
undetectable		 2hreD-3p1uA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl4 GLUTAMINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF04558
(tRNA_synt_1c_R1) 		3 ARG X 136
GLY X 147
PRO X 146
 None
 0.71A 2hreD-3tl4X:
undetectable		 2hreD-3tl4X:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		3 ARG A 101
GLY A 187
PRO A 188
 None
 0.40A 2hreD-3wxoA:
undetectable		 2hreD-3wxoA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		3 ARG A 274
GLY A 240
PRO A 239
 None
 0.71A 2hreD-4ccdA:
undetectable		 2hreD-4ccdA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		3 ARG A1019
GLY A 552
PRO A 553
 None
 0.69A 2hreD-4czwA:
undetectable		 2hreD-4czwA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		3 ARG A  57
GLY A  99
PRO A 100
 None
 0.72A 2hreD-4eiuA:
undetectable		 2hreD-4eiuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		3 ARG A 383
GLY A  53
PRO A  54
 None
 0.77A 2hreD-4fwgA:
undetectable		 2hreD-4fwgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		3 ARG A 396
GLY A 464
PRO A 465
 None
 0.65A 2hreD-4g3fA:
undetectable		 2hreD-4g3fA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hec -

(-) 		PF16473
(DUF5051) 		3 ARG A  67
GLY A 105
PRO A 106
 None
 0.74A 2hreD-4hecA:
undetectable		 2hreD-4hecA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hri HETEROCYST
DIFFERENTIATION
CONTROL PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 3 ARG B  10
GLY B  12
PRO B  13
 None
 0.69A 2hreD-4hriB:
undetectable		 2hreD-4hriB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i67 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		no annotation 3 ARG A 487
GLY A 442
PRO A 443
 None
 0.68A 2hreD-4i67A:
undetectable		 2hreD-4i67A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		3 ARG A 394
GLY A 462
PRO A 463
 None
 0.71A 2hreD-4idtA:
undetectable		 2hreD-4idtA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iov CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		3 ARG A 569
GLY A 526
PRO A 527
 None
 0.64A 2hreD-4iovA:
undetectable		 2hreD-4iovA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js7 CELLULOSE BINDING
PROTEIN

(Clavibacter
michiganensis) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		3 ARG A  62
GLY A 107
PRO A 108
 None
 0.75A 2hreD-4js7A:
undetectable		 2hreD-4js7A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1o CATENIN ALPHA-2

(Mus musculus) 		PF01044
(Vinculin) 		3 ARG A 730
GLY A 733
PRO A 734
 None
 0.68A 2hreD-4k1oA:
undetectable		 2hreD-4k1oA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica) 		PF02917
(Pertussis_S1) 		3 ARG G  85
GLY G 201
PRO G 202
 None
 0.42A 2hreD-4k6lG:
undetectable		 2hreD-4k6lG:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ARG A6149
GLY A6134
PRO A6133
 None
 0.73A 2hreD-4opfA:
undetectable		 2hreD-4opfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		3 ARG A 462
GLY A 153
PRO A 154
 None
 0.64A 2hreD-4pucA:
undetectable		 2hreD-4pucA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 ARG A 337
GLY A  73
PRO A  72
 None
 0.70A 2hreD-4qb9A:
undetectable		 2hreD-4qb9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		3 ARG A 168
GLY A  98
PRO A  99
 None
 0.59A 2hreD-4qkfA:
undetectable		 2hreD-4qkfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		3 ARG A 303
GLY A  74
PRO A  75
 None
 0.67A 2hreD-4r3uA:
undetectable		 2hreD-4r3uA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1

(Populus tremula
x Populus
tremuloides) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ARG A  18
GLY A 111
PRO A 112
 None
 0.75A 2hreD-4ri6A:
undetectable		 2hreD-4ri6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		3 ARG A 324
GLY A 434
PRO A 433
 None
 0.72A 2hreD-4wyiA:
5.1		 2hreD-4wyiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 ARG A 924
GLY A 965
PRO A 966
 None
 0.49A 2hreD-4zmhA:
undetectable		 2hreD-4zmhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq8 ISOPRENOID SYNTHASE

(Streptomyces
lydicus) 		no annotation 3 ARG A 323
GLY A  87
PRO A  86
 None
 0.58A 2hreD-4zq8A:
undetectable		 2hreD-4zq8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 ARG A1779
GLY A1813
PRO A1814
 None
 0.60A 2hreD-5a22A:
undetectable		 2hreD-5a22A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Paraburkholderia
xenovorans) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ARG A 376
GLY A 289
PRO A 290
 None
 0.50A 2hreD-5aewA:
undetectable		 2hreD-5aewA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN

(Parabacteroides
distasonis) 		PF17128
(DUF5107) 		3 ARG A 440
GLY A 195
PRO A 194
 None
 0.75A 2hreD-5cd6A:
undetectable		 2hreD-5cd6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		3 ARG A  43
GLY A 242
PRO A 243
 None
 0.49A 2hreD-5d4kA:
undetectable		 2hreD-5d4kA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ARG A  24
GLY A  72
PRO A  73
 None
 0.76A 2hreD-5k1sA:
undetectable		 2hreD-5k1sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		3 ARG A 170
GLY A 231
PRO A 230
 None
 0.59A 2hreD-5lm7A:
undetectable		 2hreD-5lm7A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 ARG A 110
GLY A 115
PRO A 116
 None
 0.71A 2hreD-5medA:
undetectable		 2hreD-5medA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 3 ARG A 105
GLY A 382
PRO A 383
 None
 0.69A 2hreD-5oc1A:
undetectable		 2hreD-5oc1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		3 ARG A 227
GLY A 370
PRO A 371
 None
 0.64A 2hreD-5udyA:
undetectable		 2hreD-5udyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus) 		no annotation 3 ARG A 197
GLY A 311
PRO A 312
 None
 0.73A 2hreD-5ux4A:
undetectable		 2hreD-5ux4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfz GP33

(Mycobacterium
virus Brujita) 		no annotation 3 ARG A 138
GLY A 205
PRO A 206
 None
 0.63A 2hreD-5vfzA:
undetectable		 2hreD-5vfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		3 ARG A 270
GLY A 118
PRO A 119
 None
 0.63A 2hreD-5vn6A:
undetectable		 2hreD-5vn6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y16 DUAL SPECIFICITY
PHOSPHATASE 28

(Homo sapiens) 		no annotation 3 ARG A  67
GLY A  57
PRO A  58
 None
 0.75A 2hreD-5y16A:
undetectable		 2hreD-5y16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN

(Mus musculus) 		no annotation 3 ARG A 204
GLY A 238
PRO A 239
 None
 0.71A 2hreD-5z1wA:
undetectable		 2hreD-5z1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a70 -

(-) 		no annotation 3 ARG B3970
GLY B3745
PRO B3746
 None
 0.61A 2hreD-6a70B:
undetectable		 2hreD-6a70B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btg FUCULOSE PHOSPHATE
ALDOLASE

(Bacillus
thuringiensis) 		no annotation 3 ARG A 150
GLY A 122
PRO A 123
 None
 0.75A 2hreD-6btgA:
undetectable		 2hreD-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 3 ARG 1 238
GLY 1 368
PRO 1 369
 None
 0.40A 2hreD-6c261:
undetectable		 2hreD-6c261:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 3 ARG A 414
GLY A 499
PRO A 500
 None
 0.66A 2hreD-6c66A:
undetectable		 2hreD-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuk CYTOCHROME C

(Rhodothermus
marinus) 		no annotation 3 ARG A  85
GLY A  18
PRO A  19
 None
 0.70A 2hreD-6cukA:
undetectable		 2hreD-6cukA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 3 ARG D 581
GLY D 552
PRO D 553
 None
 0.75A 2hreD-6eq8D:
undetectable		 2hreD-6eq8D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN

(Azotobacter
vinelandii) 		no annotation 3 ARG A 441
GLY A 428
PRO A 429
 None
 0.75A 2hreD-6feaA:
undetectable		 2hreD-6feaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 3 ARG A 115
GLY A 102
PRO A 103
 None
 0.76A 2hreD-6gnfA:
2.9		 2hreD-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h7x -

(-) 		no annotation 3 ARG A  64
GLY A  95
PRO A  96
 None
 0.71A 2hreD-6h7xA:
undetectable		 2hreD-6h7xA:
undetectable