SIMILAR PATTERNS OF AMINO ACIDS FOR 2HRE_B_CHDB701_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cov COXSACKIEVIRUS COAT
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		3 LYS 3 226
GLY 3  90
PRO 3  89
 None
 0.74A 2hreB-1cov3:
0.0		 2hreB-1cov3:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		3 LYS A 124
GLY A 198
PRO A 197
 None
 0.97A 2hreB-1f8rA:
0.0		 2hreB-1f8rA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		3 LYS A 151
GLY A 140
PRO A 141
 None
 0.93A 2hreB-1i6qA:
0.0		 2hreB-1i6qA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		3 LYS A 402
GLY A 174
PRO A 175
 None
 0.96A 2hreB-1ii0A:
0.4		 2hreB-1ii0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfl ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		3 LYS A 164
GLY A   9
PRO A  43
 None
 1.00A 2hreB-1jflA:
1.7		 2hreB-1jflA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhw MACROPHAGE CAPPING
PROTEIN

(Homo sapiens) 		PF00626
(Gelsolin) 		3 LYS A 252
GLY A 224
PRO A 225
 None
 0.59A 2hreB-1jhwA:
0.2		 2hreB-1jhwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		3 LYS A 524
GLY A 499
PRO A 500
 None
 0.93A 2hreB-1jnfA:
0.6		 2hreB-1jnfA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		3 LYS A  90
GLY A 278
PRO A 279
 None
 0.60A 2hreB-1lbqA:
46.7		 2hreB-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		3 LYS C 226
GLY C  90
PRO C  89
 None
 0.94A 2hreB-1mqtC:
0.0		 2hreB-1mqtC:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE III

(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		PF00116
(COX2)
PF02790
(COX2_TM)
PF00510
(COX3) 		3 LYS C 110
GLY B 197
PRO B 196
 PC1  C 301 (-4.5A)
None
None
 0.81A 2hreB-1qleC:
undetectable		 2hreB-1qleC:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 LYS B 224
GLY B 103
PRO B 104
 FAD  B1900 (-2.8A)
None
None
 1.01A 2hreB-1sb3B:
undetectable		 2hreB-1sb3B:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv SEROTRANSFERRIN,
C-LOBE

(Homo sapiens) 		PF00405
(Transferrin) 		3 LYS E 524
GLY E 499
PRO E 500
 None
 0.94A 2hreB-1suvE:
undetectable		 2hreB-1suvE:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		3 LYS A 124
GLY A 198
PRO A 197
 None
 1.01A 2hreB-1tdkA:
undetectable		 2hreB-1tdkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC

(Escherichia
coli) 		PF04127
(DFP) 		3 LYS A 385
GLY A 196
PRO A 197
 None
 0.75A 2hreB-1u7wA:
undetectable		 2hreB-1u7wA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upn ECHOVIRUS 11 COAT
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		3 LYS C 226
GLY C  90
PRO C  89
 None
 0.85A 2hreB-1upnC:
undetectable		 2hreB-1upnC:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v89 HYPOTHETICAL PROTEIN
KIAA0053

(Homo sapiens) 		PF00169
(PH) 		3 LYS A   1
GLY A 114
PRO A 115
 None
 0.88A 2hreB-1v89A:
undetectable		 2hreB-1v89A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		3 LYS A  24
GLY A 266
PRO A 267
 None
 0.94A 2hreB-1vbjA:
undetectable		 2hreB-1vbjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we9 PHD FINGER FAMILY
PROTEIN

(Arabidopsis
thaliana) 		PF00628
(PHD) 		3 LYS A  51
GLY A  60
PRO A  61
 None
 0.66A 2hreB-1we9A:
undetectable		 2hreB-1we9A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz6 HMG-BOX
TRANSCRIPTION FACTOR
BBX

(Mus musculus) 		PF00505
(HMG_box) 		3 LYS A   1
GLY A  74
PRO A  73
 None
 0.85A 2hreB-1wz6A:
undetectable		 2hreB-1wz6A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 LYS A 330
GLY A 511
PRO A 512
 None
None
MAN  A3008 (-4.3A)
 0.94A 2hreB-1xc6A:
undetectable		 2hreB-1xc6A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		3 LYS B 145
GLY B 259
PRO B 232
 None
 1.01A 2hreB-1y56B:
undetectable		 2hreB-1y56B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL

(Homo sapiens) 		PF02817
(E3_binding) 		3 LYS K 165
GLY K 153
PRO K 154
 None
 0.93A 2hreB-1zy8K:
undetectable		 2hreB-1zy8K:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7t DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1

(Rattus
norvegicus) 		PF00035
(dsrm) 		3 LYS A  64
GLY A  51
PRO A  52
 None
 0.92A 2hreB-2b7tA:
undetectable		 2hreB-2b7tA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bty ACETYLGLUTAMATE
KINASE

(Thermotoga
maritima) 		PF00696
(AA_kinase) 		3 LYS A  27
GLY A  63
PRO A  64
 NLG  A1284 (-3.4A)
NLG  A1284 ( 4.2A)
None
 0.84A 2hreB-2btyA:
undetectable		 2hreB-2btyA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cod CENTAURIN-DELTA 1

(Homo sapiens) 		PF00169
(PH) 		3 LYS A  99
GLY A 111
PRO A 112
 None
 0.89A 2hreB-2codA:
undetectable		 2hreB-2codA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crc UBIQUITIN
CONJUGATING ENZYME 7
INTERACTING PROTEIN
3

(Homo sapiens) 		PF00641
(zf-RanBP) 		3 LYS A  21
GLY A  48
PRO A  49
 None
 0.86A 2hreB-2crcA:
undetectable		 2hreB-2crcA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh9 HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN M

(Homo sapiens) 		PF00076
(RRM_1) 		3 LYS A 583
GLY A 617
PRO A 618
 None
 0.91A 2hreB-2dh9A:
undetectable		 2hreB-2dh9A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djr ZINC FINGER BED
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF02892
(zf-BED) 		3 LYS A  56
GLY A  72
PRO A  73
 None
 1.00A 2hreB-2djrA:
undetectable		 2hreB-2djrA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		3 LYS A 458
GLY A 538
PRO A 539
 None
 0.93A 2hreB-2du7A:
undetectable		 2hreB-2du7A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		3 LYS A 334
GLY A 297
PRO A 299
 None
 1.00A 2hreB-2ftwA:
undetectable		 2hreB-2ftwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 LYS A 340
GLY A 388
PRO A 389
 None
 0.91A 2hreB-2fuqA:
undetectable		 2hreB-2fuqA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		3 LYS A 150
GLY A 147
PRO A 146
 KCX  A 149 ( 3.4A)
None
None
 1.02A 2hreB-2gwnA:
undetectable		 2hreB-2gwnA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5k UNCHARACTERIZED
PROTEIN RHR2

(Rhodobacter
sphaeroides) 		PF07896
(DUF1674) 		3 LYS A  37
GLY A  44
PRO A  45
 None
 0.85A 2hreB-2k5kA:
undetectable		 2hreB-2k5kA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwl ACYL CARRIER PROTEIN

(Borreliella
burgdorferi) 		PF00550
(PP-binding) 		3 LYS A  80
GLY A   3
PRO A   2
 None
 0.95A 2hreB-2kwlA:
undetectable		 2hreB-2kwlA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE

(Bacteroides
thetaiotaomicron) 		PF00596
(Aldolase_II) 		3 LYS A  70
GLY A 135
PRO A 134
 None
 1.01A 2hreB-2opiA:
undetectable		 2hreB-2opiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		3 LYS A  33
GLY A 211
PRO A 210
 None
 0.43A 2hreB-2ozeA:
3.2		 2hreB-2ozeA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		3 LYS A 133
GLY A 458
PRO A 459
 HEM  A 600 (-2.9A)
None
None
 0.75A 2hreB-2rchA:
undetectable		 2hreB-2rchA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU

(Homo sapiens) 		PF00041
(fn3)
PF00047
(ig)
PF00629
(MAM) 		3 LYS A 232
GLY A 291
PRO A 292
 None
 0.99A 2hreB-2v5yA:
undetectable		 2hreB-2v5yA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6

(Homo sapiens) 		PF00651
(BTB) 		3 LYS A  90
GLY A  15
PRO A  16
 None
 0.71A 2hreB-2vkpA:
undetectable		 2hreB-2vkpA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		3 LYS B 857
GLY B1518
PRO B1517
 None
 0.76A 2hreB-2xwbB:
undetectable		 2hreB-2xwbB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 LYS A  94
GLY A 324
PRO A 325
 None
 0.94A 2hreB-2yfqA:
4.4		 2hreB-2yfqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		3 LYS A 277
GLY A 313
PRO A 312
 CA  A1333 (-4.7A)
None
None
 0.88A 2hreB-2yikA:
undetectable		 2hreB-2yikA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Sulfolobus
solfataricus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		3 LYS A  12
GLY A 282
PRO A 281
 None
 1.00A 2hreB-2zucA:
undetectable		 2hreB-2zucA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		3 LYS A 557
GLY A 534
PRO A 535
 None
 0.76A 2hreB-3cwgA:
undetectable		 2hreB-3cwgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1l PUTATIVE NADP
OXIDOREDUCTASE
BF3122

(Bacteroides
fragilis) 		PF03807
(F420_oxidored)
PF10728
(DUF2520) 		3 LYS A 213
GLY A 225
PRO A 226
 None
 0.96A 2hreB-3d1lA:
undetectable		 2hreB-3d1lA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		3 LYS A  88
GLY A 413
PRO A 414
 HEM  A 600 (-3.1A)
None
None
 0.74A 2hreB-3danA:
undetectable		 2hreB-3danA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Vibrio cholerae) 		PF00793
(DAHP_synth_1) 		3 LYS A  60
GLY A 251
PRO A 252
 None
 0.99A 2hreB-3e9aA:
undetectable		 2hreB-3e9aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9x UNCHARACTERIZED
PROTEIN PSPTO_3016

(Pseudomonas
syringae group
genomosp. 3) 		PF04237
(YjbR) 		3 LYS A  57
GLY A  98
PRO A  99
 None
 1.01A 2hreB-3h9xA:
undetectable		 2hreB-3h9xA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1

(Vitis vinifera) 		PF05368
(NmrA) 		3 LYS A 279
GLY A 133
PRO A 132
 None
 0.87A 2hreB-3i5mA:
2.2		 2hreB-3i5mA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 LYS A 542
GLY A 561
PRO A 562
 None
 0.83A 2hreB-3ilvA:
undetectable		 2hreB-3ilvA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu OXYGEN-EVOLVING
ENHANCER PROTEIN 3,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF05757
(PsbQ) 		3 LYS Q   1
GLY Q   8
PRO Q   9
 None
 1.01A 2hreB-3jcuQ:
undetectable		 2hreB-3jcuQ:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 LYS A 104
GLY A 327
PRO A 328
 None
 0.94A 2hreB-3k92A:
3.9		 2hreB-3k92A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktd PREPHENATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF02153
(PDH) 		3 LYS A 111
GLY A 187
PRO A 188
 None
 0.94A 2hreB-3ktdA:
undetectable		 2hreB-3ktdA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		3 LYS A 440
GLY A 496
PRO A 495
 None
 0.88A 2hreB-3o98A:
undetectable		 2hreB-3o98A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oad RENIN

(Homo sapiens) 		PF00026
(Asp) 		3 LYS B 197
GLY B 310
PRO B 311
 None
 1.00A 2hreB-3oadB:
undetectable		 2hreB-3oadB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyo HEMOPEXIN FOLD
PROTEIN CP4

(Vigna
unguiculata) 		PF00045
(Hemopexin) 		3 LYS A 148
GLY A 100
PRO A 101
 None
 1.02A 2hreB-3oyoA:
undetectable		 2hreB-3oyoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		3 LYS A  55
GLY A 133
PRO A 134
 None
 0.97A 2hreB-3p8aA:
undetectable		 2hreB-3p8aA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prh TRYPTOPHANYL-TRNA
SYNTHETASE

(Bacillus
subtilis) 		PF00579
(tRNA-synt_1b) 		3 LYS A 193
GLY A 145
PRO A 144
 None
 0.90A 2hreB-3prhA:
undetectable		 2hreB-3prhA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 LYS A 521
GLY A 427
PRO A 426
 None
 0.97A 2hreB-3ps5A:
undetectable		 2hreB-3ps5A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13416
(SBP_bac_8) 		3 LYS A 123
GLY A 263
PRO A 260
 LYS  A 123 ( 0.0A)
GLY  A 263 ( 0.0A)
PRO  A 260 ( 1.1A)
 0.95A 2hreB-3pu5A:
undetectable		 2hreB-3pu5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkd CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		3 LYS A 554
GLY A 591
PRO A 592
 None
 0.84A 2hreB-3rkdA:
undetectable		 2hreB-3rkdA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb SINGLE DOMAIN
ANTIBODY VHH
RNA-EDITING COMPLEX
PROTEIN MP42

(Lama glama;
Trypanosoma
brucei) 		PF07686
(V-set)
no annotation 		3 LYS A   4
GLY C 326
PRO C 325
 None
 0.86A 2hreB-3stbA:
undetectable		 2hreB-3stbA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sv0 CASEIN KINASE I-LIKE

(Oryza sativa) 		PF00069
(Pkinase) 		3 LYS A  38
GLY A  86
PRO A  87
 None
 0.95A 2hreB-3sv0A:
undetectable		 2hreB-3sv0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		3 LYS A 295
GLY A  33
PRO A  32
 MG  A 501 (-2.2A)
None
None
 0.96A 2hreB-3t5tA:
2.3		 2hreB-3t5tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 3 LYS A 582
GLY A 450
PRO A 449
 TRQ  A 581 ( 2.7A)
TRQ  A 581 ( 3.3A)
LYS  A 801 (-4.4A)
 1.02A 2hreB-3wevA:
undetectable		 2hreB-3wevA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zeh PC4 AND
SFRS1-INTERACTING
PROTEIN

(Homo sapiens) 		PF00855
(PWWP) 		3 LYS A  34
GLY A  54
PRO A  55
 None
 1.01A 2hreB-3zehA:
undetectable		 2hreB-3zehA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zet PUTATIVE M22
PEPTIDASE YEAZ

(Salmonella
enterica) 		PF00814
(Peptidase_M22) 		3 LYS A 201
GLY A  64
PRO A  65
 None
 0.96A 2hreB-3zetA:
undetectable		 2hreB-3zetA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LYS A 225
GLY A  23
PRO A  18
 None
 0.89A 2hreB-4aw2A:
undetectable		 2hreB-4aw2A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		3 LYS A 510
GLY A 365
PRO A 366
 None
 0.54A 2hreB-4b56A:
undetectable		 2hreB-4b56A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		3 LYS A 286
GLY A  44
PRO A  45
 None
 0.97A 2hreB-4bx9A:
undetectable		 2hreB-4bx9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		3 LYS A  91
GLY A 151
PRO A 154
 None
 0.98A 2hreB-4e4gA:
undetectable		 2hreB-4e4gA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		3 LYS A 315
GLY A  91
PRO A  92
 None
 0.83A 2hreB-4emyA:
2.0		 2hreB-4emyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 LYS A  36
GLY A 250
PRO A 251
 None
 0.92A 2hreB-4gybA:
undetectable		 2hreB-4gybA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS H 208
GLY H 113
PRO H 112
 None
 0.96A 2hreB-4ht1H:
undetectable		 2hreB-4ht1H:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwc CHAPERONE PROTEIN
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		3 LYS A 548
GLY A 468
PRO A 470
 None
 1.00A 2hreB-4jwcA:
undetectable		 2hreB-4jwcA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 LYS A 285
GLY A 218
PRO A 217
 None
 0.76A 2hreB-4mrqA:
undetectable		 2hreB-4mrqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		3 LYS A 897
GLY A 923
PRO A 924
 None
 0.78A 2hreB-4ogcA:
undetectable		 2hreB-4ogcA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio cholerae) 		PF04205
(FMN_bind) 		3 LYS C 112
GLY C 245
PRO C 246
 None
 0.93A 2hreB-4p6vC:
undetectable		 2hreB-4p6vC:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio cholerae) 		PF04205
(FMN_bind) 		3 LYS C 112
GLY C 245
PRO C 246
 None
 1.01A 2hreB-4u9sC:
undetectable		 2hreB-4u9sC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 LYS A 380
GLY A 434
PRO A 435
 ACT  A1007 ( 3.6A)
GOL  A1006 ( 2.9A)
None
 0.89A 2hreB-4zmhA:
undetectable		 2hreB-4zmhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ay6 FLAGELLAR HOOK
PROTEIN FLGE

(Caulobacter
vibrioides) 		PF07559
(FlaE) 		3 LYS A 236
GLY A 356
PRO A 357
 None
 0.75A 2hreB-5ay6A:
undetectable		 2hreB-5ay6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 3 LYS A  11
GLY A 521
PRO A 522
 None
 1.00A 2hreB-5b7iA:
undetectable		 2hreB-5b7iA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		3 LYS A  89
GLY A 210
PRO A 211
 None
 0.99A 2hreB-5cadA:
undetectable		 2hreB-5cadA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 LYS A 239
GLY A   9
PRO A  10
 None
 0.99A 2hreB-5cjfA:
undetectable		 2hreB-5cjfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 LYS A 447
GLY A  57
PRO A  58
 None
 0.92A 2hreB-5favA:
undetectable		 2hreB-5favA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Escherichia
coli;
Mus musculus) 		PF00027
(cNMP_binding)
PF13416
(SBP_bac_8) 		3 LYS A 532
GLY A-313
PRO A-312
 None
 0.87A 2hreB-5jonA:
undetectable		 2hreB-5jonA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 LYS A 484
GLY A 517
PRO A 516
 None
 0.61A 2hreB-5jouA:
undetectable		 2hreB-5jouA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L14,
MITOCHONDRIAL

(Homo sapiens) 		PF00238
(Ribosomal_L14) 		3 LYS L  31
GLY L  93
PRO L  94
 A  A2469 ( 3.8A)
None
None
 0.94A 2hreB-5oolL:
undetectable		 2hreB-5oolL:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L41,
MITOCHONDRIAL

(Homo sapiens) 		PF09809
(MRP-L27) 		3 LYS 9  15
GLY 9  26
PRO 9  27
 None
G  A2339 ( 4.6A)
G  A2339 ( 3.8A)
 0.88A 2hreB-5ool9:
undetectable		 2hreB-5ool9:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDG

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF12838
(Fer4_7) 		3 LYS B 140
GLY G  37
PRO G  38
 None
 0.91A 2hreB-5t5iB:
undetectable		 2hreB-5t5iB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 LYS A 450
GLY A 480
PRO A 502
 None
 0.94A 2hreB-5t88A:
undetectable		 2hreB-5t88A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		3 LYS A 172
GLY A 198
PRO A 199
 NAP  A 301 (-2.6A)
NAP  A 301 (-4.6A)
None
 1.03A 2hreB-5tgdA:
3.0		 2hreB-5tgdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		3 LYS A 124
GLY A 198
PRO A 197
 None
 0.95A 2hreB-5ts5A:
undetectable		 2hreB-5ts5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upr TRIOSEPHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00121
(TIM) 		3 LYS A 233
GLY A 224
PRO A 223
 None
 0.95A 2hreB-5uprA:
undetectable		 2hreB-5uprA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8k P800 REACTION CENTER
CORE PROTEIN

(Heliobacterium
modesticaldum) 		PF00223
(PsaA_PsaB) 		3 LYS A 587
GLY A 434
PRO A 435
 None
SF4  A1029 (-3.6A)
None
 1.00A 2hreB-5v8kA:
undetectable		 2hreB-5v8kA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		3 LYS F 252
GLY F  58
PRO F  57
 None
 0.88A 2hreB-5x5yF:
undetectable		 2hreB-5x5yF:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		no annotation 3 LYS A  87
GLY A  -2
PRO A  -1
 None
 0.95A 2hreB-5yksA:
undetectable		 2hreB-5yksA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cer PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
ALPHA, SOMATIC FORM,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 LYS A 248
GLY A  20
PRO A  21
 None
 0.94A 2hreB-6cerA:
undetectable		 2hreB-6cerA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6du8 -

(-) 		no annotation 3 LYS A 204
GLY A 238
PRO A 239
 None
 0.90A 2hreB-6du8A:
undetectable		 2hreB-6du8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		3 LYS C 654
GLY A 673
PRO A 674
 None
 1.01A 2hreB-6f5oC:
undetectable		 2hreB-6f5oC:
undetectable