SIMILAR PATTERNS OF AMINO ACIDS FOR 2HRC_B_CHDB1605_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 LEU A 330
LEU A 322
ILE A  25
LEU A 308
VAL A 318
 None
 1.00A 2hrcB-1c3rA:
undetectable		 2hrcB-1c3rA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fta FRUCTOSE-1,6-BISPHOS
PHATASE

(Homo sapiens) 		PF00316
(FBPase) 		5 LEU A 173
PHE A 193
LEU A 175
ILE A  44
LEU A  30
 None
None
None
None
AMP  A 338 ( 4.2A)
 1.21A 2hrcB-1ftaA:
undetectable		 2hrcB-1ftaA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 ILE A 313
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 1.14A 2hrcB-1lbqA:
48.5		 2hrcB-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		9 LEU A  62
PHE A  63
ILE A  91
HIS A 235
LEU A 237
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 0.40A 2hrcB-1lbqA:
48.5		 2hrcB-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 MET A  46
HIS A 235
LEU A 237
PRO A 238
VAL A 241
TRP A 282
 None
 0.97A 2hrcB-1lbqA:
48.5		 2hrcB-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		7 PHE A  63
LEU A  68
ILE A  91
HIS A 235
LEU A 237
VAL A 277
TRP A 282
 None
 1.14A 2hrcB-1lbqA:
48.5		 2hrcB-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 328
LEU A 331
LEU A 277
PRO A 210
VAL A 238
 None
 1.15A 2hrcB-1ozhA:
undetectable		 2hrcB-1ozhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 LEU A  30
LEU A 136
ILE A  44
LEU A 167
VAL A 163
 None
 1.09A 2hrcB-1pujA:
4.3		 2hrcB-1pujA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A  64
PHE A  55
ILE A 169
VAL A  27
VAL A 177
 None
 1.20A 2hrcB-1qi7A:
undetectable		 2hrcB-1qi7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rni ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.15A 2hrcB-1rniA:
undetectable		 2hrcB-1rniA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 MET A 205
LEU A 201
PHE A 197
LEU A  34
ILE A 106
 None
 1.24A 2hrcB-1vqzA:
undetectable		 2hrcB-1vqzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 LEU A 433
LEU A 404
MET A 405
LEU A 309
VAL A 411
 None
 1.17A 2hrcB-1xa6A:
undetectable		 2hrcB-1xa6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		5 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.20A 2hrcB-1yirA:
undetectable		 2hrcB-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A  39
PHE A  67
LEU A  52
LEU A  29
VAL A  34
 None
 1.25A 2hrcB-1yrgA:
undetectable		 2hrcB-1yrgA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2

(Archaeoglobus
fulgidus) 		PF02552
(CO_dh) 		5 LEU A 171
LEU A 174
LEU A 111
PRO A  38
VAL A  64
 None
 1.12A 2hrcB-1ytlA:
3.6		 2hrcB-1ytlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 PHE A 209
LEU A 155
ILE A 241
LEU A 188
PRO A 189
 None
 1.18A 2hrcB-2acvA:
3.7		 2hrcB-2acvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2x 2-DEOXY-SCYLLO-INOSO
SE SYNTHASE

(Bacillus
circulans) 		PF01761
(DHQ_synthase) 		5 LEU A 368
LEU A 301
ILE A 364
LEU A 189
VAL A 185
 None
 1.15A 2hrcB-2d2xA:
2.5		 2hrcB-2d2xA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dos ATAXIN-3

(Homo sapiens) 		PF02099
(Josephin) 		5 LEU A  33
PHE A  28
LEU A  91
VAL A 165
VAL A  86
 None
 1.18A 2hrcB-2dosA:
undetectable		 2hrcB-2dosA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 MET A 752
LEU A 748
LEU A 370
ILE A 728
LEU A 161
 None
 1.17A 2hrcB-2eaeA:
undetectable		 2hrcB-2eaeA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es6 VTS1P

(Saccharomyces
cerevisiae) 		PF07647
(SAM_2) 		5 LEU A 447
LEU A 463
ILE A 518
LEU A 488
VAL A 493
 None
 1.14A 2hrcB-2es6A:
undetectable		 2hrcB-2es6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z CHEMOTAXIS PROTEIN
CHEC

(Thermotoga
maritima) 		PF04509
(CheC) 		5 PHE A 198
LEU A 129
MET A 201
ILE A 165
VAL A  41
 None
 1.17A 2hrcB-2f9zA:
undetectable		 2hrcB-2f9zA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 LEU A 103
PHE A 124
ILE A 158
LEU A  78
PRO A  81
 None
 1.14A 2hrcB-2fi1A:
2.9		 2hrcB-2fi1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 LEU A  23
LEU A  60
ILE A 180
LEU A  80
VAL A  86
 None
 1.21A 2hrcB-2fmtA:
2.4		 2hrcB-2fmtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.22A 2hrcB-2hmiD:
undetectable		 2hrcB-2hmiD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoq PUTATIVE
HAD-HYDROLASE PH1655

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 LEU A 103
LEU A 106
ILE A 128
LEU A 171
VAL A   2
 None
 1.21A 2hrcB-2hoqA:
2.3		 2hrcB-2hoqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		5 LEU A  90
LEU A  94
ILE A 271
HIS A  73
VAL A 160
 GUN  A 503 (-4.9A)
GUN  A 503 (-4.4A)
None
FE  A 501 (-3.4A)
None
 1.00A 2hrcB-2i9uA:
undetectable		 2hrcB-2i9uA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF08712
(Nfu_N) 		5 LEU A  63
LEU A 105
ILE A  58
LEU A  30
VAL A  74
 None
 1.23A 2hrcB-2ltlA:
undetectable		 2hrcB-2ltlA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onk MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Archaeoglobus
fulgidus) 		PF00005
(ABC_tran) 		5 LEU A 147
LEU A   3
MET A  22
VAL A  18
VAL A 183
 None
 1.13A 2hrcB-2onkA:
undetectable		 2hrcB-2onkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		5 LEU A 426
LEU A 397
MET A 398
LEU A 302
VAL A 404
 None
 1.14A 2hrcB-2osaA:
undetectable		 2hrcB-2osaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmb GENERAL SECRETION
PATHWAY PROTEIN F

(Vibrio cholerae) 		PF00482
(T2SSF) 		5 LEU A 146
LEU A 150
LEU A 105
VAL A  92
VAL A 112
 None
 1.20A 2hrcB-2vmbA:
undetectable		 2hrcB-2vmbA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		5 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 1.11A 2hrcB-2w3wA:
undetectable		 2hrcB-2w3wA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 154
LEU A 151
ILE A 139
LEU A 369
VAL A  67
 None
None
DIF  A1374 (-4.7A)
None
None
 0.97A 2hrcB-2wekA:
2.3		 2hrcB-2wekA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv7 CG10997-PA

(Drosophila
melanogaster) 		no annotation 5 LEU A 132
LEU A 147
ILE A 227
LEU A 201
PRO A 198
 None
 1.20A 2hrcB-2yv7A:
undetectable		 2hrcB-2yv7A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 MET A 243
LEU A 277
LEU A 280
LEU A 231
VAL A 255
 None
 1.07A 2hrcB-2z63A:
undetectable		 2hrcB-2z63A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.96A 2hrcB-3a8kA:
undetectable		 2hrcB-3a8kA:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		12 MET A  76
LEU A  92
PHE A  93
LEU A  98
MET A  99
ILE A 119
HIS A 263
LEU A 265
PRO A 266
VAL A 269
VAL A 305
TRP A 310
 CHD  A   1 ( 3.8A)
CHD  A   1 (-4.8A)
CHD  A   1 ( 4.7A)
CHD  A   1 (-4.3A)
CHD  A   2 (-4.0A)
None
CHD  A   1 (-4.3A)
None
CHD  A   2 ( 4.5A)
None
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 0.42A 2hrcB-3aqiA:
60.7		 2hrcB-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		5 LEU A 125
LEU A 262
LEU A 317
PRO A 318
VAL A 321
 None
 1.21A 2hrcB-3caxA:
undetectable		 2hrcB-3caxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxl N-CHIMERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 LEU A 426
LEU A 397
MET A 398
LEU A 302
VAL A 404
 None
 1.10A 2hrcB-3cxlA:
undetectable		 2hrcB-3cxlA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.92A 2hrcB-3fxiA:
undetectable		 2hrcB-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 MET A 243
LEU A 277
LEU A 280
LEU A 231
VAL A 255
 None
 1.06A 2hrcB-3fxiA:
undetectable		 2hrcB-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 285
ILE A 273
LEU A 113
PRO A 153
VAL A 156
 None
 1.22A 2hrcB-3gp0A:
undetectable		 2hrcB-3gp0A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE

(Clostridium
acetobutylicum) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		5 LEU A 229
PHE A 230
LEU A  98
VAL A 102
VAL A 244
 None
 1.18A 2hrcB-3i0wA:
undetectable		 2hrcB-3i0wA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 LEU A 496
ILE A 510
LEU A 121
VAL A 668
VAL A 519
 None
 1.18A 2hrcB-3jb9A:
undetectable		 2hrcB-3jb9A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		5 LEU A1300
PHE A1380
LEU A1388
ILE A1285
LEU A1362
 None
 1.23A 2hrcB-3jroA:
undetectable		 2hrcB-3jroA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.12A 2hrcB-3m1mA:
undetectable		 2hrcB-3m1mA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxq SENSOR PROTEIN

(Vibrio cholerae) 		PF08448
(PAS_4) 		5 LEU A  86
PHE A  55
LEU A  62
VAL A 121
VAL A  31
 None
 1.17A 2hrcB-3mxqA:
undetectable		 2hrcB-3mxqA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n91 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735) 		5 LEU A 133
PHE A 137
LEU A 152
PRO A 151
VAL A  86
 None
 1.08A 2hrcB-3n91A:
undetectable		 2hrcB-3n91A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 MET A 281
LEU A 265
LEU A 241
LEU A 252
VAL A 249
 None
 1.22A 2hrcB-3o6nA:
undetectable		 2hrcB-3o6nA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 LEU B 104
LEU B 115
ILE B 207
LEU B 168
VAL B  17
 None
 1.17A 2hrcB-3ufxB:
5.5		 2hrcB-3ufxB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
ILE A 550
VAL A 380
VAL A 458
 None
 1.15A 2hrcB-3v4oA:
2.2		 2hrcB-3v4oA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 MET A 307
LEU A 260
LEU A 283
VAL A 274
VAL A  17
 None
 1.02A 2hrcB-3vcyA:
undetectable		 2hrcB-3vcyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vk9 GLUTATHIONE
S-TRANSFERASE DELTA

(Bombyx mori) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		5 LEU A  24
LEU A  84
ILE A   3
LEU A  99
VAL A  95
 None
 1.21A 2hrcB-3vk9A:
undetectable		 2hrcB-3vk9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 224
LEU A 221
ILE A 231
LEU A 195
VAL A 189
 None
 1.14A 2hrcB-3wpeA:
undetectable		 2hrcB-3wpeA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		5 LEU A 379
LEU A 276
PRO A 277
VAL A 280
TRP A 139
 None
 1.01A 2hrcB-3zdpA:
undetectable		 2hrcB-3zdpA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.15A 2hrcB-3zyiA:
undetectable		 2hrcB-3zyiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 LEU A 182
LEU A  72
ILE A 322
LEU A 130
VAL A  58
 None
 1.24A 2hrcB-4h59A:
undetectable		 2hrcB-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
 None
 1.21A 2hrcB-4hq1A:
undetectable		 2hrcB-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
ILE A 550
VAL A 380
VAL A 458
 None
 1.18A 2hrcB-4i1pA:
2.1		 2hrcB-4i1pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k82 LV-RANASPUMIN
(LV-RSN-1)

(Leptodactylus
vastus) 		no annotation 5 LEU A 198
PHE A 191
LEU A 201
LEU A 138
VAL A 145
 None
 1.01A 2hrcB-4k82A:
undetectable		 2hrcB-4k82A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		5 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.22A 2hrcB-4lctA:
undetectable		 2hrcB-4lctA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU A1305
PHE A1342
LEU A1353
LEU A1260
VAL A1331
 None
 1.17A 2hrcB-4ll6A:
undetectable		 2hrcB-4ll6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.24A 2hrcB-4mn8A:
undetectable		 2hrcB-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.23A 2hrcB-4mnaA:
undetectable		 2hrcB-4mnaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A1167
ILE A1096
LEU A 946
VAL A 949
VAL A1000
 None
 1.20A 2hrcB-4n78A:
undetectable		 2hrcB-4n78A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh0 BETA-LACTAMASE
OXA-58

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		5 MET A 127
ILE A 176
LEU A 217
VAL A 209
VAL A 185
 KCX  A  86 ( 3.6A)
None
None
None
None
 1.20A 2hrcB-4oh0A:
undetectable		 2hrcB-4oh0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 LEU A 183
LEU A 179
ILE A 143
LEU A 195
VAL A 164
 None
 1.21A 2hrcB-4tx8A:
undetectable		 2hrcB-4tx8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A 371
LEU A 392
MET A 389
VAL A 381
TRP A 410
 None
 1.15A 2hrcB-4u7lA:
undetectable		 2hrcB-4u7lA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uip REPEBODY (RAC1)

(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU B  71
LEU B  93
ILE B  23
LEU B 109
VAL B  66
 None
 1.23A 2hrcB-4uipB:
undetectable		 2hrcB-4uipB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 LEU A 323
LEU A 335
LEU A 127
VAL A 122
TRP A 124
 None
 1.23A 2hrcB-4wd1A:
4.3		 2hrcB-4wd1A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.22A 2hrcB-4z0cA:
undetectable		 2hrcB-4z0cA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		5 LEU A 144
LEU A 183
PRO A 276
VAL A 277
VAL A  38
 None
 1.18A 2hrcB-4zrqA:
undetectable		 2hrcB-4zrqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4p REPEBODY

(synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A  70
LEU A  92
ILE A  22
LEU A 107
VAL A  65
 None
 1.06A 2hrcB-5b4pA:
undetectable		 2hrcB-5b4pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 276
LEU A 111
LEU A  77
PRO A  78
VAL A  81
 None
 0.98A 2hrcB-5bz4A:
undetectable		 2hrcB-5bz4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.10A 2hrcB-5cniA:
4.7		 2hrcB-5cniA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 LEU A 527
LEU A 547
ILE A 532
LEU A 562
VAL A 321
 None
 1.21A 2hrcB-5cslA:
2.6		 2hrcB-5cslA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d17 TRANSPOSON TN7
TRANSPOSITION
PROTEIN TNSE

(Escherichia
coli) 		no annotation 5 LEU A 399
LEU A 514
PRO A 511
VAL A 519
VAL A 508
 None
 1.11A 2hrcB-5d17A:
undetectable		 2hrcB-5d17A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddv 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		5 LEU A 169
PHE A 164
LEU A  91
PRO A   8
VAL A  52
 None
 1.16A 2hrcB-5ddvA:
undetectable		 2hrcB-5ddvA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3

(Mus musculus) 		PF02338
(OTU) 		5 LEU A 275
LEU A 303
ILE A 210
LEU A 236
PRO A 235
 None
 1.20A 2hrcB-5dq6A:
undetectable		 2hrcB-5dq6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		5 LEU A  46
ILE A  95
LEU A 174
VAL A 171
VAL A 145
 None
 1.12A 2hrcB-5ebbA:
undetectable		 2hrcB-5ebbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		5 LEU A  43
ILE A  92
LEU A 171
VAL A 168
VAL A 142
 None
GOL  A 522 ( 4.4A)
None
None
None
 1.09A 2hrcB-5fcaA:
undetectable		 2hrcB-5fcaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 LEU A 298
MET A 315
ILE A 289
LEU A 513
VAL A 504
 None
 1.20A 2hrcB-5fmqA:
undetectable		 2hrcB-5fmqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		5 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.25A 2hrcB-5fqlA:
undetectable		 2hrcB-5fqlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 434
LEU A 410
ILE A 447
LEU A 381
VAL A 375
 None
 1.09A 2hrcB-5ixqA:
undetectable		 2hrcB-5ixqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.11A 2hrcB-5kznA:
4.5		 2hrcB-5kznA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC

(Spinacia
oleracea;
Spinacia
oleracea) 		PF00276
(Ribosomal_L23)
PF00831
(Ribosomal_L29) 		5 LEU Z  92
ILE V 147
LEU Z 152
PRO Z 149
VAL Z 146
 None
 1.12A 2hrcB-5mlcZ:
undetectable		 2hrcB-5mlcZ:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovu BETA-PROTEOBACTERIA
PROTEASOME HOMOLOGUE

(Cupriavidus
metallidurans) 		no annotation 5 LEU A  87
LEU A  60
MET A  57
VAL A  40
VAL A 121
 None
 1.13A 2hrcB-5ovuA:
undetectable		 2hrcB-5ovuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 MET A 307
LEU A 260
LEU A 283
VAL A 274
VAL A  16
 None
 1.05A 2hrcB-5u4hA:
undetectable		 2hrcB-5u4hA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.22A 2hrcB-5vl1A:
undetectable		 2hrcB-5vl1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 5 ILE A   5
LEU A 359
PRO A 360
VAL A  21
TRP A  20
 None
 1.14A 2hrcB-5vqdA:
3.4		 2hrcB-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 341
LEU A 331
ILE A 358
LEU A 260
VAL A 254
 None
 1.12A 2hrcB-5wjcA:
undetectable		 2hrcB-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 5 MET A 285
LEU A 252
LEU A 190
PRO A 167
VAL A 165
 None
 1.16A 2hrcB-5x7nA:
3.4		 2hrcB-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 5 LEU A 200
PHE A 191
LEU A 235
ILE A 162
LEU A 242
 None
 1.11A 2hrcB-5xnpA:
undetectable		 2hrcB-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 5 LEU B 167
PHE B 157
LEU B 188
MET B 185
ILE B 149
 None
 1.20A 2hrcB-5xwuB:
undetectable		 2hrcB-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 LEU A 225
LEU A 222
ILE A 232
LEU A 196
VAL A 190
 None
 1.09A 2hrcB-5y3jA:
undetectable		 2hrcB-5y3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 5 LEU A 134
PRO A 135
VAL A 138
VAL A  87
TRP A 214
 None
 1.23A 2hrcB-5y4gA:
undetectable		 2hrcB-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 LEU A 225
LEU A 222
ILE A 232
LEU A 196
VAL A 190
 None
 1.08A 2hrcB-5zlnA:
undetectable		 2hrcB-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 LEU A  29
ILE A 115
LEU A  51
PRO A  52
VAL A  55
 MMV  A 202 (-4.7A)
None
None
MMV  A 202 ( 4.6A)
MMV  A 202 (-4.8A)
 1.06A 2hrcB-6cxmA:
undetectable		 2hrcB-6cxmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 ILE A 382
LEU A 247
PRO A 248
VAL A 251
VAL A  79
 None
 1.24A 2hrcB-6dllA:
undetectable		 2hrcB-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6euv POLYMERASE BASIC
PROTEIN 2

(Influenza A
virus) 		no annotation 5 LEU A 298
MET A 315
ILE A 289
LEU A 513
VAL A 504
 None
 1.15A 2hrcB-6euvA:
undetectable		 2hrcB-6euvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 MET A 495
LEU A 518
LEU A 522
LEU A 437
VAL A 399
 None
 1.09A 2hrcB-6f5dA:
2.8		 2hrcB-6f5dA:
undetectable