SIMILAR PATTERNS OF AMINO ACIDS FOR 2HRC_A_CHDA703

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adr P22 C2 REPRESSOR

(Salmonella
virus P22) 		PF01381
(HTH_3) 		4 LEU A  50
PRO A  45
LEU A  53
ARG A  13
 None
 1.43A 2hrcA-1adrA:
undetectable		 2hrcA-1adrA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aut ACTIVATED PROTEIN C

(Homo sapiens) 		PF00008
(EGF)
PF14670
(FXa_inhibition) 		4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
 None
 1.40A 2hrcA-1autL:
undetectable		 2hrcA-1autL:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo6 ESTROGEN
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		4 LEU A 143
PRO A 152
LEU A 144
ARG A 257
 None
None
None
A3P  A 301 (-4.0A)
 1.09A 2hrcA-1bo6A:
0.0		 2hrcA-1bo6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 LEU A 810
PRO A 753
LEU A 807
ARG A 805
 None
 1.41A 2hrcA-1c7tA:
0.3		 2hrcA-1c7tA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		4 LEU B 146
PRO B 145
LEU B  91
ARG B  80
 None
 1.32A 2hrcA-1ccwB:
0.3		 2hrcA-1ccwB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		4 LEU A  93
PRO A 127
LEU A 157
ARG A 164
 None
 1.40A 2hrcA-1d2rA:
0.4		 2hrcA-1d2rA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 LEU A 255
PRO A 257
LEU A 144
ARG A 534
 None
None
None
GLC  A 996 (-4.1A)
 1.39A 2hrcA-1e4oA:
2.0		 2hrcA-1e4oA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase) 		4 LEU A 129
PRO A 130
LEU A  99
ARG A  95
 None
None
None
ALS  A  91 (-4.6A)
 1.39A 2hrcA-1fsuA:
0.0		 2hrcA-1fsuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.16A 2hrcA-1hl2A:
0.2		 2hrcA-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8n ANTI-PLATELET
PROTEIN

(Haementeria
officinalis) 		no annotation 4 LEU A  55
PRO A  56
LEU A  60
ARG A  98
 None
 1.42A 2hrcA-1i8nA:
undetectable		 2hrcA-1i8nA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9s MRNA CAPPING ENZYME

(Mus musculus) 		PF00782
(DSPc) 		4 LEU A  25
PRO A  26
LEU A  27
ARG A  15
 None
None
None
IPA  A 600 (-4.1A)
 1.31A 2hrcA-1i9sA:
undetectable		 2hrcA-1i9sA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jh3 TYROSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF01479
(S4) 		4 LEU A  37
PRO A  33
LEU A  34
ARG A  88
 None
 1.27A 2hrcA-1jh3A:
undetectable		 2hrcA-1jh3A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		4 LEU A 240
PRO A 235
LEU A 239
ARG A 246
 None
 1.41A 2hrcA-1mtpA:
undetectable		 2hrcA-1mtpA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A1300
PRO A1301
LEU A1302
ARG A1311
 None
 1.13A 2hrcA-1p0cA:
undetectable		 2hrcA-1p0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		4 LEU A  75
PRO A  77
LEU A  76
ARG A   6
 None
 1.36A 2hrcA-1ps6A:
undetectable		 2hrcA-1ps6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgo ANAEROBIC COBALAMIN
BIOSYNTHETIC COBALT
CHELATASE

(Salmonella
enterica) 		PF06180
(CbiK) 		4 LEU A  63
PRO A  62
LEU A  66
ARG A 101
 None
 1.00A 2hrcA-1qgoA:
15.3		 2hrcA-1qgoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6m RIBONUCLEASE PH

(Pseudomonas
aeruginosa) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 108
PRO A 155
LEU A 151
ARG A 148
 None
 1.33A 2hrcA-1r6mA:
undetectable		 2hrcA-1r6mA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfs HYPOTHETICAL PROTEIN

(Geobacillus
stearothermophilus) 		PF08924
(DUF1906) 		4 LEU A  36
PRO A  63
LEU A  46
ARG A  48
 None
 1.38A 2hrcA-1sfsA:
undetectable		 2hrcA-1sfsA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU A 151
PRO A 196
LEU A 414
ARG A 411
 None
 1.37A 2hrcA-1ufaA:
undetectable		 2hrcA-1ufaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		4 LEU A 295
PRO A 296
LEU A 294
ARG A 338
 None
 1.19A 2hrcA-1ujnA:
undetectable		 2hrcA-1ujnA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		4 LEU A 218
PRO A 219
LEU A 285
ARG A 241
 None
 1.37A 2hrcA-1wzzA:
undetectable		 2hrcA-1wzzA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdn RNA EDITING LIGASE
MP52

(Trypanosoma
brucei) 		PF09414
(RNA_ligase) 		4 LEU A 266
PRO A 267
LEU A 269
ARG A 244
 None
 1.32A 2hrcA-1xdnA:
undetectable		 2hrcA-1xdnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 LEU A  87
PRO A 206
LEU A  49
ARG A  52
 None
 1.30A 2hrcA-1xt8A:
undetectable		 2hrcA-1xt8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE

(Bos taurus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A 115
PRO A 118
LEU A 120
ARG A 123
 None
 1.33A 2hrcA-1zyeA:
undetectable		 2hrcA-1zyeA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU A 305
PRO A 306
LEU A 349
ARG A 355
 None
 1.43A 2hrcA-2b9bA:
undetectable		 2hrcA-2b9bA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c46 MRNA CAPPING ENZYME

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A  25
PRO A  26
LEU A  27
ARG A  15
 None
 1.34A 2hrcA-2c46A:
undetectable		 2hrcA-2c46A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A1401 (-3.9A)
NAD  A1401 (-3.1A)
 1.40A 2hrcA-2dfvA:
undetectable		 2hrcA-2dfvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8g HYPOTHETICAL PROTEIN
PH0536

(Pyrococcus
horikoshii) 		PF01588
(tRNA_bind) 		4 LEU A 124
PRO A  59
LEU A  62
ARG A  53
 None
 1.25A 2hrcA-2e8gA:
undetectable		 2hrcA-2e8gA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idg HYPOTHETICAL PROTEIN
AF0160

(Archaeoglobus
fulgidus) 		PF02613
(Nitrate_red_del) 		4 LEU A 139
PRO A 140
LEU A  51
ARG A  52
 None
 1.42A 2hrcA-2idgA:
undetectable		 2hrcA-2idgA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		4 LEU A 500
PRO A 501
LEU A 522
ARG A 523
 None
 1.34A 2hrcA-2ktqA:
undetectable		 2hrcA-2ktqA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00581
(Rhodanese) 		4 LEU A 155
PRO A 152
LEU A 269
ARG A 178
 None
 1.29A 2hrcA-2oucA:
undetectable		 2hrcA-2oucA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq5 PROTEIN JUMONJI

(Mus musculus) 		PF01388
(ARID) 		4 LEU A 645
PRO A 644
LEU A 651
ARG A 683
 None
 1.39A 2hrcA-2rq5A:
undetectable		 2hrcA-2rq5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU B 291
PRO B 295
LEU B 307
ARG B 287
 None
 1.24A 2hrcA-2v9tB:
undetectable		 2hrcA-2v9tB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 LEU A 211
PRO A 212
LEU A 214
ARG A 173
 None
 1.41A 2hrcA-2vw8A:
undetectable		 2hrcA-2vw8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzz RV0802C

(Mycobacterium
tuberculosis) 		PF13302
(Acetyltransf_3) 		4 LEU A  80
PRO A  81
LEU A  82
ARG A  11
 None
 1.34A 2hrcA-2vzzA:
undetectable		 2hrcA-2vzzA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 LEU A 613
PRO A 423
LEU A 610
ARG A 609
 None
 1.26A 2hrcA-2wkpA:
3.1		 2hrcA-2wkpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xci 3-DEOXY-D-MANNO-2-OC
TULOSONIC ACID
TRANSFERASE

(Aquifex
aeolicus) 		PF04413
(Glycos_transf_N) 		4 LEU A 209
PRO A 211
LEU A 243
ARG A 225
 None
 1.35A 2hrcA-2xciA:
undetectable		 2hrcA-2xciA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 LEU A 375
PRO A 376
LEU A 379
ARG A 550
 None
 1.28A 2hrcA-2xydA:
undetectable		 2hrcA-2xydA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 LEU A 112
PRO A 111
LEU A 183
ARG A 157
 None
 1.37A 2hrcA-2ywbA:
undetectable		 2hrcA-2ywbA:
22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 LEU A 101
PRO A 102
LEU A 107
ARG A 114
 CHD  A   3 ( 4.9A)
CHD  A   3 ( 4.7A)
CHD  A   3 ( 4.6A)
CHD  A   2 (-3.6A)
 0.23A 2hrcA-3aqiA:
60.0		 2hrcA-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION

(Ruegeria sp.
TM1040) 		PF14563
(DUF4444)
PF16917
(BPL_LplA_LipB_2) 		4 LEU A 159
PRO A 156
LEU A  48
ARG A  49
 None
None
None
CA  A 235 ( 4.1A)
 1.33A 2hrcA-3bfmA:
undetectable		 2hrcA-3bfmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		4 LEU B  97
PRO B  98
LEU B 190
ARG B 128
 None
 0.82A 2hrcA-3bn3B:
undetectable		 2hrcA-3bn3B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cio TYROSINE-PROTEIN
KINASE ETK

(Escherichia
coli) 		PF13614
(AAA_31) 		4 LEU A 570
PRO A 618
LEU A 624
ARG A 629
 None
 1.23A 2hrcA-3cioA:
undetectable		 2hrcA-3cioA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 4 LEU A 184
PRO A 187
LEU A 381
ARG A 196
 None
 1.31A 2hrcA-3cv3A:
2.8		 2hrcA-3cv3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo sapiens) 		PF00008
(EGF)
PF14670
(FXa_inhibition) 		4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
 None
 1.35A 2hrcA-3f6uL:
undetectable		 2hrcA-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		4 LEU A 381
PRO A 432
LEU A 436
ARG A 438
 None
 1.40A 2hrcA-3fcrA:
undetectable		 2hrcA-3fcrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.40A 2hrcA-3fd2A:
undetectable		 2hrcA-3fd2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		4 LEU A 237
PRO A 238
LEU A 212
ARG A 272
 None
 1.20A 2hrcA-3gxoA:
undetectable		 2hrcA-3gxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 LEU A  42
PRO A  43
LEU A  47
ARG A  24
 None
 0.83A 2hrcA-3i2tA:
undetectable		 2hrcA-3i2tA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A  69
PRO A  88
LEU A  66
ARG A 301
 None
 1.27A 2hrcA-3ihvA:
undetectable		 2hrcA-3ihvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mip MSO-8G

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.39A 2hrcA-3mipA:
undetectable		 2hrcA-3mipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 LEU A 722
PRO A 721
LEU A 725
ARG A 699
 None
 1.25A 2hrcA-3nowA:
undetectable		 2hrcA-3nowA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.22A 2hrcA-3p2mA:
2.5		 2hrcA-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdx TYROSINE
AMINOTRANSFERASE

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 LEU A  87
PRO A  88
LEU A 283
ARG A 281
 None
None
LLP  A 280 ( 4.5A)
None
 1.30A 2hrcA-3pdxA:
undetectable		 2hrcA-3pdxA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		4 LEU A 136
PRO A 135
LEU A 139
ARG A 214
 None
 1.34A 2hrcA-3pmkA:
undetectable		 2hrcA-3pmkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 147
PRO A 176
LEU A  94
ARG A  96
 None
 1.35A 2hrcA-3ri6A:
undetectable		 2hrcA-3ri6A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 LEU A 277
PRO A 279
LEU A 303
ARG A 297
 None
 1.15A 2hrcA-3s2uA:
undetectable		 2hrcA-3s2uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00581
(Rhodanese) 		4 LEU B 155
PRO B 152
LEU B 269
ARG B 178
 None
 1.32A 2hrcA-3tg1B:
undetectable		 2hrcA-3tg1B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		4 LEU B 419
PRO B 420
LEU B 423
ARG B 402
 None
 1.41A 2hrcA-3thwB:
undetectable		 2hrcA-3thwB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		4 LEU A 403
PRO A 404
LEU A 389
ARG A 453
 None
 1.08A 2hrcA-3tp9A:
undetectable		 2hrcA-3tp9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 LEU A 254
PRO A 255
LEU A 301
ARG A 265
 None
 1.43A 2hrcA-3ttfA:
undetectable		 2hrcA-3ttfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vhl DEDICATOR OF
CYTOKINESIS PROTEIN
8

(Mus musculus) 		PF06920
(DHR-2) 		4 LEU A1991
PRO A1990
LEU A2058
ARG A2055
 None
 1.27A 2hrcA-3vhlA:
undetectable		 2hrcA-3vhlA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		4 LEU A 191
PRO A 190
LEU A 179
ARG A  77
 None
 1.25A 2hrcA-4e4jA:
undetectable		 2hrcA-4e4jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frw POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 4

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 LEU A  50
PRO A  51
LEU A 141
ARG A 142
 None
 1.21A 2hrcA-4frwA:
undetectable		 2hrcA-4frwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfi MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 303
PRO A 300
LEU A 302
ARG A  25
 None
None
None
GLU  A 403 (-3.5A)
 1.14A 2hrcA-4gfiA:
undetectable		 2hrcA-4gfiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		4 LEU A  81
PRO A  82
LEU A  72
ARG A  71
 None
0J9  A 302 (-4.5A)
None
None
 1.17A 2hrcA-4gkhA:
undetectable		 2hrcA-4gkhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE
POLO-LIKE KINASE

(Danio rerio;
Danio rerio) 		PF00069
(Pkinase)
PF00659
(POLO_box) 		4 LEU A 300
PRO A 297
LEU B 496
ARG B 498
 None
 1.36A 2hrcA-4j7bA:
undetectable		 2hrcA-4j7bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mda MARINER MOS1
TRANSPOSASE

(Drosophila
mauritiana) 		PF01359
(Transposase_1) 		4 LEU A 329
PRO A 330
LEU A 149
ARG A 151
 None
 1.38A 2hrcA-4mdaA:
undetectable		 2hrcA-4mdaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		4 LEU A 288
PRO A 289
LEU A 290
ARG A 315
 None
 1.33A 2hrcA-4nxkA:
undetectable		 2hrcA-4nxkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 LEU A 797
PRO A  36
LEU A 800
ARG A 804
 None
 1.24A 2hrcA-4ogcA:
undetectable		 2hrcA-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oib INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		4 LEU A  97
PRO A  98
LEU A 190
ARG A 128
 None
 0.75A 2hrcA-4oibA:
undetectable		 2hrcA-4oibA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onr DECORIN-BINDING
PROTEIN DBPA

(Borreliella
burgdorferi) 		PF02352
(Decorin_bind) 		4 LEU A 126
PRO A 125
LEU A 129
ARG A  84
 None
 1.11A 2hrcA-4onrA:
undetectable		 2hrcA-4onrA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7b MARINER MOS1
TRANSPOSASE

(Drosophila
mauritiana) 		PF01359
(Transposase_1) 		4 LEU A 329
PRO A 330
LEU A 149
ARG A 151
 None
 1.36A 2hrcA-4u7bA:
undetectable		 2hrcA-4u7bA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uur PUTATIVE
HEMOGLOBIN-LIKE
OXYGEN-BINDING
PROTEIN

(Pseudoalteromonas
haloplanktis) 		PF01152
(Bac_globin) 		4 LEU A  54
PRO A  53
LEU A 105
ARG A 106
 HEM  A 700 (-4.7A)
None
HEM  A 700 ( 4.3A)
None
 1.30A 2hrcA-4uurA:
undetectable		 2hrcA-4uurA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 805
PRO A 814
LEU A 833
ARG A 832
 None
 1.42A 2hrcA-4wovA:
undetectable		 2hrcA-4wovA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.31A 2hrcA-4zasA:
undetectable		 2hrcA-4zasA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 199
PRO A 200
LEU A 204
ARG A 211
 None
 1.17A 2hrcA-4zwvA:
undetectable		 2hrcA-4zwvA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 292
PRO A 291
LEU A 293
ARG A 456
 None
 1.39A 2hrcA-5agaA:
undetectable		 2hrcA-5agaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b01 MOEN5

(Streptomyces
viridosporus) 		no annotation 4 LEU A  59
PRO A  39
LEU A  42
ARG A 171
 None
 1.21A 2hrcA-5b01A:
undetectable		 2hrcA-5b01A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0l MOEN5,DNA-BINDING
PROTEIN 7D

(Sulfolobus
solfataricus;
Streptomyces
viridosporus) 		no annotation 4 LEU A  59
PRO A  39
LEU A  42
ARG A 171
 None
 1.24A 2hrcA-5b0lA:
undetectable		 2hrcA-5b0lA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		4 LEU A 202
PRO A 239
LEU A 237
ARG A 163
 None
 1.40A 2hrcA-5by6A:
undetectable		 2hrcA-5by6A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 LEU A 808
PRO A 807
LEU A 626
ARG A 624
 None
 1.20A 2hrcA-5ezrA:
undetectable		 2hrcA-5ezrA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		4 LEU A1236
PRO A1237
LEU A1262
ARG A1268
 None
 1.07A 2hrcA-5fv0A:
undetectable		 2hrcA-5fv0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 4 LEU G   7
PRO G   6
LEU G  20
ARG G  21
 None
 1.22A 2hrcA-5h0rG:
undetectable		 2hrcA-5h0rG:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE

(Bacillus
anthracis) 		PF04127
(DFP) 		4 LEU A 376
PRO A 377
LEU A 379
ARG A 386
 None
 0.81A 2hrcA-5intA:
3.2		 2hrcA-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf5 MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 LEU A 270
PRO A 269
LEU A 271
ARG A 281
 None
 1.23A 2hrcA-5lf5A:
undetectable		 2hrcA-5lf5A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 LEU A 270
PRO A 269
LEU A 271
ARG A 281
 None
 1.28A 2hrcA-5lfrA:
undetectable		 2hrcA-5lfrA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 LEU A1019
PRO A1018
LEU A 533
ARG A 535
 None
 1.39A 2hrcA-5lq3A:
undetectable		 2hrcA-5lq3A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 LEU A 553
PRO A 549
LEU A 627
ARG A 643
 None
 1.30A 2hrcA-5opqA:
undetectable		 2hrcA-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 LEU A 503
PRO A 540
LEU A 538
ARG A 463
 None
 1.33A 2hrcA-5t0lA:
undetectable		 2hrcA-5t0lA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3t FUSION PROTEIN OF
NUCLEOPROTEIN AND
MINOR NUCLEOPROTEIN
VP30

(Zaire
ebolavirus) 		PF05505
(Ebola_NP)
PF11507
(Transcript_VP30) 		4 LEU A 249
PRO A 250
LEU A 188
ARG A 195
 None
 1.02A 2hrcA-5t3tA:
undetectable		 2hrcA-5t3tA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 LEU A 251
PRO A 252
LEU A 140
ARG A  64
 None
 1.24A 2hrcA-5t65A:
undetectable		 2hrcA-5t65A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE

(Bacillus
licheniformis) 		no annotation 4 LEU A 345
PRO A 344
LEU A 348
ARG A 331
 LEU  A 345 ( 0.5A)
PRO  A 344 ( 1.1A)
LEU  A 348 ( 0.5A)
ARG  A 331 ( 0.6A)
 1.42A 2hrcA-5xluA:
undetectable		 2hrcA-5xluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 LEU B  56
PRO B  60
LEU B  72
ARG B  71
 None
 1.32A 2hrcA-5xwuB:
undetectable		 2hrcA-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y05 MSMEG_4306

(Mycolicibacterium
smegmatis) 		no annotation 4 LEU A 238
PRO A 198
LEU A 237
ARG A 229
 None
 1.01A 2hrcA-5y05A:
undetectable		 2hrcA-5y05A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii) 		PF01501
(Glyco_transf_8) 		4 LEU A1391
PRO A1392
LEU A1370
ARG A1369
 None
 1.36A 2hrcA-5y7fA:
undetectable		 2hrcA-5y7fA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 4 LEU A 440
PRO A 439
LEU A 443
ARG A 405
 None
 1.29A 2hrcA-6bo6A:
undetectable		 2hrcA-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 LEU B 497
PRO B 496
LEU B 500
ARG B 201
 None
 1.22A 2hrcA-6f0kB:
undetectable		 2hrcA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn0 -

(-) 		no annotation 4 LEU A  24
PRO A  21
LEU A  23
ARG A  73
 None
 1.32A 2hrcA-6fn0A:
undetectable		 2hrcA-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL

(endosymbiont of
Tevnia
jerichonana) 		no annotation 4 LEU A 247
PRO A 248
LEU A 250
ARG A 120
 None
 1.37A 2hrcA-6fvsA:
undetectable		 2hrcA-6fvsA:
undetectable