SIMILAR PATTERNS OF AMINO ACIDS FOR 2HRC_A_CHDA702

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 LEU A 291
PRO A   6
VAL A 298
MET A 267
 None
 1.26A 2hrcA-1gveA:
0.1		 2hrcA-1gveA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		4 ARG A 114
LEU A 140
VAL A 198
MET A  12
 None
 1.27A 2hrcA-1h1yA:
undetectable		 2hrcA-1h1yA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 ARG A 365
LEU A 366
PRO A 193
MET A 218
 None
 1.32A 2hrcA-1hc7A:
undetectable		 2hrcA-1hc7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2m 17-KDA
PKC-POTENTIATED
INHIBITORY PROTEIN
OF PP1

(Sus scrofa) 		PF05361
(PP1_inhibitor) 		4 ARG A  27
LEU A  94
PRO A  51
VAL A  54
 None
 1.30A 2hrcA-1j2mA:
undetectable		 2hrcA-1j2mA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 LEU A 107
PRO A 130
VAL A  29
MET A 127
 None
 1.32A 2hrcA-1lcyA:
undetectable		 2hrcA-1lcyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		4 ARG A 397
LEU A 354
PRO A  28
VAL A  25
 None
 1.20A 2hrcA-1lxyA:
undetectable		 2hrcA-1lxyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 MET A 214
ARG A  80
PRO A 277
VAL A  84
 None
 1.38A 2hrcA-1m7sA:
undetectable		 2hrcA-1m7sA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1njk HYPOTHETICAL PROTEIN
YBAW

(Escherichia
coli) 		PF13279
(4HBT_2) 		4 MET A  44
ARG A 124
LEU A  79
VAL A 131
 None
 1.27A 2hrcA-1njkA:
undetectable		 2hrcA-1njkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 MET A  76
LEU A 191
PRO A 126
TRP A 215
 None
 1.26A 2hrcA-1ofeA:
1.4		 2hrcA-1ofeA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1

(Mus musculus) 		PF03036
(Perilipin) 		4 LEU A 208
PRO A 417
VAL A 422
MET A 419
 None
 1.36A 2hrcA-1sziA:
undetectable		 2hrcA-1sziA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uap PROCOLLAGEN
C-PROTEINASE
ENHANCER PROTEIN

(Homo sapiens) 		PF01759
(NTR) 		4 LEU A 141
PRO A 102
VAL A 131
MET A 104
 None
 1.01A 2hrcA-1uapA:
undetectable		 2hrcA-1uapA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF06026
(Rib_5-P_isom_A) 		4 ARG A  44
LEU A  50
PRO A  57
VAL A  26
 None
 1.36A 2hrcA-1uj4A:
undetectable		 2hrcA-1uj4A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		4 ARG A 272
LEU A 273
PRO A 287
VAL A 216
 None
 1.24A 2hrcA-1wxxA:
undetectable		 2hrcA-1wxxA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 MET A1115
ARG A1077
PRO A1106
TRP A1100
 None
 1.34A 2hrcA-1yguA:
undetectable		 2hrcA-1yguA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 MET A 157
ARG A  14
LEU A 361
VAL A 165
 None
 1.37A 2hrcA-1ysjA:
3.1		 2hrcA-1ysjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		4 LEU A  14
PRO A 274
VAL A 414
MET A 130
 None
 1.25A 2hrcA-1z3vA:
undetectable		 2hrcA-1z3vA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9s TOPOISOMERASE I-LIKE
PROTEIN

(Leishmania
donovani) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N) 		4 ARG A 116
LEU A 113
PRO A 184
VAL A  83
 None
 1.31A 2hrcA-2b9sA:
undetectable		 2hrcA-2b9sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL UPF0116
PROTEIN YHEM
HYPOTHETICAL PROTEIN
YHEL

(Escherichia
coli;
Escherichia
coli) 		PF02635
(DrsE)
PF04077
(DsrH) 		4 MET C   1
ARG C  19
LEU B 106
VAL B   7
 None
 1.11A 2hrcA-2d1pC:
undetectable		 2hrcA-2d1pC:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkx SAM POINTED
DOMAIN-CONTAINING
ETS TRANSCRIPTION
FACTOR

(Homo sapiens) 		PF02198
(SAM_PNT) 		4 MET A  63
PRO A  24
VAL A  32
TRP A  27
 None
 1.37A 2hrcA-2dkxA:
undetectable		 2hrcA-2dkxA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 MET B 756
PRO B 779
MET B 787
TRP B 788
 None
 1.05A 2hrcA-2fjaB:
undetectable		 2hrcA-2fjaB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnx HYPOTHETICAL PROTEIN

(Mus musculus) 		PF09404
(DUF2003) 		4 ARG A 371
LEU A 375
PRO A 357
VAL A 405
 None
 1.19A 2hrcA-2gnxA:
undetectable		 2hrcA-2gnxA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 MET A  93
ARG A 137
LEU A 134
VAL A 184
 None
 1.28A 2hrcA-2guhA:
undetectable		 2hrcA-2guhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PRO X 331
VAL X 309
MET X 297
TRP X 295
 None
None
UNX  X 804 (-3.8A)
None
 1.06A 2hrcA-2iv2X:
undetectable		 2hrcA-2iv2X:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 MET A 350
ARG A 437
PRO A 363
MET A 361
 None
 1.17A 2hrcA-2ovjA:
undetectable		 2hrcA-2ovjA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rr8 IQGAP1 PROTEIN

(Homo sapiens) 		PF00307
(CH) 		4 MET A 145
LEU A 108
PRO A 134
VAL A 116
 None
 1.19A 2hrcA-2rr8A:
undetectable		 2hrcA-2rr8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2

(Bacillus
subtilis) 		PF00884
(Sulfatase) 		4 MET A 227
LEU A 602
PRO A 528
VAL A 524
 None
 1.25A 2hrcA-2w8dA:
undetectable		 2hrcA-2w8dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		4 MET A 230
ARG A 245
LEU A 246
VAL A 184
 None
 1.37A 2hrcA-2xfsA:
undetectable		 2hrcA-2xfsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		4 LEU A 132
PRO A 382
VAL A 208
MET A 379
 None
 1.36A 2hrcA-2xkaA:
undetectable		 2hrcA-2xkaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0b PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
5

(Homo sapiens) 		PF00686
(CBM_20) 		4 LEU A  79
PRO A  47
VAL A  24
TRP A  57
 None
 1.33A 2hrcA-2z0bA:
undetectable		 2hrcA-2z0bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		4 ARG A 271
LEU A 268
PRO A 155
VAL A 149
 None
 1.35A 2hrcA-2z3tA:
undetectable		 2hrcA-2z3tA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		7 MET A  99
ARG A 114
LEU A 115
PRO A 266
VAL A 305
MET A 308
TRP A 310
 CHD  A   2 (-4.0A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.8A)
CHD  A   2 ( 4.5A)
CHD  A   1 ( 4.9A)
None
CHD  A   2 (-4.7A)
 0.26A 2hrcA-3aqiA:
60.0		 2hrcA-3aqiA:
99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 MET A  99
LEU A  89
PRO A 266
TRP A 310
 CHD  A   2 (-4.0A)
None
CHD  A   2 ( 4.5A)
CHD  A   2 (-4.7A)
 1.22A 2hrcA-3aqiA:
60.0		 2hrcA-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm7 PROTEIN OF UNKNOWN
FUNCTION WITH
FERREDOXIN-LIKE FOLD

(Caulobacter
vibrioides) 		PF03992
(ABM) 		4 MET A  83
ARG A  43
LEU A  41
VAL A  21
 None
 1.35A 2hrcA-3bm7A:
undetectable		 2hrcA-3bm7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		4 ARG A 103
LEU A 206
PRO A 180
VAL A 194
 None
 1.28A 2hrcA-3c0kA:
undetectable		 2hrcA-3c0kA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 ARG A 294
LEU A 299
PRO A 312
VAL A 309
 None
UDP  A 600 ( 4.3A)
None
None
 1.30A 2hrcA-3c4qA:
2.9		 2hrcA-3c4qA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 LEU A 483
PRO A 255
VAL A 507
TRP A 510
 None
 1.38A 2hrcA-3cwgA:
undetectable		 2hrcA-3cwgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4d ESTERASE D

(Agrobacterium
fabrum) 		PF00756
(Esterase) 		4 ARG A 140
LEU A 276
PRO A  79
VAL A  76
 None
 1.18A 2hrcA-3e4dA:
2.4		 2hrcA-3e4dA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcx S-FORMYLGLUTATHIONE
HYDROLASE

(Homo sapiens) 		PF00756
(Esterase) 		4 ARG A 142
LEU A 280
PRO A  81
VAL A  78
 None
 1.18A 2hrcA-3fcxA:
2.0		 2hrcA-3fcxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7v O-SUCCINYLBENZOATE
SYNTHASE

(Thermosynechococcus
elongatus) 		PF13378
(MR_MLE_C) 		4 LEU A 162
PRO A 142
VAL A 137
MET A 140
 None
 1.34A 2hrcA-3h7vA:
undetectable		 2hrcA-3h7vA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis) 		PF00155
(Aminotran_1_2) 		4 LEU A 236
PRO A 155
VAL A 192
TRP A 157
 None
 1.04A 2hrcA-3jtxA:
undetectable		 2hrcA-3jtxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 LEU A 393
PRO A 170
VAL A 216
TRP A 217
 None
 1.38A 2hrcA-3mgaA:
undetectable		 2hrcA-3mgaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		4 MET A 224
LEU A 402
VAL A 293
MET A 278
 None
 1.25A 2hrcA-3mveA:
2.5		 2hrcA-3mveA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py6 BETA-LACTAMASE-LIKE

(Brucella
abortus) 		PF12706
(Lactamase_B_2) 		4 ARG A  41
LEU A  13
PRO A   4
VAL A  76
 None
 1.23A 2hrcA-3py6A:
undetectable		 2hrcA-3py6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ARG A 362
LEU A 766
VAL A 365
TRP A 332
 None
 1.30A 2hrcA-3sdqA:
undetectable		 2hrcA-3sdqA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ARG X 264
PRO X 277
VAL X 274
MET X 391
 None
PLP  X 502 ( 4.8A)
None
None
 1.21A 2hrcA-3ss7X:
undetectable		 2hrcA-3ss7X:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t61 GLUCONOKINASE

(Sinorhizobium
meliloti) 		PF01202
(SKI) 		4 ARG A 103
LEU A 102
PRO A  43
VAL A  89
 None
 1.31A 2hrcA-3t61A:
undetectable		 2hrcA-3t61A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ub1 ORF13-LIKE PROTEIN

(Clostridium
perfringens) 		PF12642
(TpcC) 		4 ARG A 178
PRO A 225
VAL A 175
MET A 227
 None
 1.22A 2hrcA-3ub1A:
undetectable		 2hrcA-3ub1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 MET A 342
LEU A 482
PRO A 310
VAL A 362
 None
 1.36A 2hrcA-3ufbA:
undetectable		 2hrcA-3ufbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 4 MET A   0
ARG A 446
LEU A 443
VAL A 605
 None
 1.30A 2hrcA-3uk8A:
undetectable		 2hrcA-3uk8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 ARG A  15
LEU A  11
PRO A  79
MET A 136
 None
 1.25A 2hrcA-3ummA:
undetectable		 2hrcA-3ummA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		4 MET A 137
ARG A 429
PRO A 169
VAL A 231
 None
 1.35A 2hrcA-3upyA:
4.2		 2hrcA-3upyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ARG A 385
LEU A 370
PRO A 395
VAL A 366
 None
 1.34A 2hrcA-3w1gA:
undetectable		 2hrcA-3w1gA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		4 MET A 221
ARG A 355
PRO A 287
TRP A 270
 None
PO4  A 702 (-3.9A)
None
None
 1.37A 2hrcA-3wstA:
undetectable		 2hrcA-3wstA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ARG A 457
LEU A 453
PRO A 325
VAL A 365
 None
 1.29A 2hrcA-3wy2A:
undetectable		 2hrcA-3wy2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 MET A 173
LEU A1309
PRO A1337
VAL A 979
 None
 1.20A 2hrcA-4a5wA:
undetectable		 2hrcA-4a5wA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 ARG A 765
LEU A 676
PRO A 883
VAL A 821
 None
 1.38A 2hrcA-4aioA:
undetectable		 2hrcA-4aioA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE

(Bacteroides
plebeius) 		PF04616
(Glyco_hydro_43) 		4 ARG A 383
LEU A  76
PRO A 166
VAL A 103
 None
 1.12A 2hrcA-4ak5A:
undetectable		 2hrcA-4ak5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF16415
(CNOT1_CAF1_bind) 		4 LEU A1151
PRO A1086
VAL A1125
TRP A1124
 None
 1.33A 2hrcA-4ct4A:
undetectable		 2hrcA-4ct4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		4 ARG A 439
LEU A 396
PRO A  72
VAL A  69
 None
 1.12A 2hrcA-4e4jA:
undetectable		 2hrcA-4e4jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ARG A 313
LEU A 347
PRO A 266
MET A 258
 None
 1.01A 2hrcA-4fffA:
undetectable		 2hrcA-4fffA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR

(Rhodobacter
sphaeroides) 		PF13188
(PAS_8)
PF13426
(PAS_9) 		4 MET A 115
ARG A  71
VAL A  61
TRP A  53
 None
 1.37A 2hrcA-4hh2A:
undetectable		 2hrcA-4hh2A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		4 MET A 314
ARG A 183
PRO A 279
MET A 299
 None
 1.35A 2hrcA-4i6fA:
undetectable		 2hrcA-4i6fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmq BACTERIOPHAGE T5
DISTAL TAIL PROTEIN

(Escherichia
virus T5) 		no annotation 4 ARG A 201
PRO A   4
VAL A  81
MET A   1
 None
 1.15A 2hrcA-4jmqA:
undetectable		 2hrcA-4jmqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Mycobacterium
avium) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 LEU A 162
PRO A 117
VAL A 140
MET A 115
 None
 1.19A 2hrcA-4lgvA:
2.1		 2hrcA-4lgvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 ARG A 771
LEU A 698
PRO A 675
VAL A 597
 None
 1.03A 2hrcA-4o5pA:
2.5		 2hrcA-4o5pA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc8 RESTRICTION
ENDONUCLEASE ASPBHI

(Azoarcus sp.
BH72) 		PF04471
(Mrr_cat) 		4 LEU A  37
PRO A 198
VAL A 185
TRP A 184
 None
 1.21A 2hrcA-4oc8A:
undetectable		 2hrcA-4oc8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 ARG A 730
LEU A 721
PRO A1039
VAL A1041
 None
 1.34A 2hrcA-4ogcA:
undetectable		 2hrcA-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ARG A 218
LEU A 332
PRO A 230
VAL A 383
 None
 1.30A 2hrcA-4p72A:
undetectable		 2hrcA-4p72A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ps0 CASPASE-3

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 219
PRO A 155
VAL A 115
MET A  44
 None
 1.27A 2hrcA-4ps0A:
2.0		 2hrcA-4ps0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII

(Mycobacterium
ulcerans) 		PF01648
(ACPS) 		4 LEU A  11
PRO A  81
VAL A 102
TRP A  83
 None
COA  A 301 (-3.9A)
None
None
 1.36A 2hrcA-4qjlA:
undetectable		 2hrcA-4qjlA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ARG A 570
LEU A  52
PRO A 404
TRP A 402
 None
 1.27A 2hrcA-4tweA:
1.1		 2hrcA-4tweA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u63 DNA PHOTOLYASE

(Agrobacterium
fabrum) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 335
PRO A 206
VAL A 373
TRP A  54
 None
SO4  A1015 (-4.3A)
None
None
 1.20A 2hrcA-4u63A:
undetectable		 2hrcA-4u63A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuo CYTOSOLIC MALATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ARG A  22
LEU A  19
VAL A 251
TRP A 254
 None
 1.36A 2hrcA-4uuoA:
1.9		 2hrcA-4uuoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 437
PRO A 318
MET A 316
TRP A 333
 None
 1.38A 2hrcA-4uy9A:
undetectable		 2hrcA-4uy9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 MET A 259
ARG A 250
LEU A 209
VAL A 229
 None
 1.34A 2hrcA-4xriA:
undetectable		 2hrcA-4xriA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		4 LEU A 281
PRO A 173
VAL A 208
TRP A 206
 None
 0.96A 2hrcA-4z23A:
undetectable		 2hrcA-4z23A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ARG A1015
LEU A1019
PRO A1161
VAL A1164
 None
 1.11A 2hrcA-4zdnA:
undetectable		 2hrcA-4zdnA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		4 ARG A 366
LEU A 389
PRO A 165
VAL A 121
 None
 1.19A 2hrcA-5b6tA:
undetectable		 2hrcA-5b6tA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		4 LEU A  49
PRO A 217
VAL A 250
TRP A  29
 None
 1.37A 2hrcA-5bp8A:
undetectable		 2hrcA-5bp8A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00071
(Ras)
PF00620
(RhoGAP) 		4 MET A 212
ARG A 299
PRO A 225
MET A 223
 None
 1.25A 2hrcA-5c2kA:
3.2		 2hrcA-5c2kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens) 		PF04189
(Gcd10p) 		4 ARG B 417
LEU B 414
VAL B 399
MET B 206
 None
 0.94A 2hrcA-5ccxB:
undetectable		 2hrcA-5ccxB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		4 MET A 518
LEU A  40
PRO A 565
VAL A 552
 None
 1.23A 2hrcA-5dztA:
undetectable		 2hrcA-5dztA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI

(Ruegeria
pomeroyi) 		PF00107
(ADH_zinc_N) 		4 LEU A 305
PRO A  29
VAL A  63
TRP A  98
 None
 1.37A 2hrcA-5gxfA:
undetectable		 2hrcA-5gxfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j60 THIOREDOXIN
REDUCTASE

(Gloeobacter
violaceus) 		PF07992
(Pyr_redox_2) 		4 MET A 254
LEU A  87
VAL A 273
MET A 266
 None
None
None
PG4  A 403 ( 3.8A)
 1.09A 2hrcA-5j60A:
undetectable		 2hrcA-5j60A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6o PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		4 MET A2132
PRO A2163
VAL A2000
TRP A2002
 None
 1.31A 2hrcA-5j6oA:
undetectable		 2hrcA-5j6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ARG A 705
LEU A 707
VAL A 742
MET A 793
 None
 1.36A 2hrcA-5j9zA:
undetectable		 2hrcA-5j9zA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 429
PRO A 590
VAL A 565
MET A 588
 None
 1.35A 2hrcA-5jp0A:
undetectable		 2hrcA-5jp0A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		4 ARG A 256
LEU A 279
PRO A 243
MET A 245
 None
 1.36A 2hrcA-5jp9A:
undetectable		 2hrcA-5jp9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ARG A 643
LEU A 646
VAL A 630
MET A 592
 EDO  A 708 (-3.4A)
None
None
None
 1.22A 2hrcA-5k8fA:
undetectable		 2hrcA-5k8fA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 MET B 299
ARG B 325
LEU B 320
MET B 147
 None
 1.07A 2hrcA-5l3rB:
undetectable		 2hrcA-5l3rB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 ARG A1248
LEU A1254
PRO A1385
VAL A1367
 None
 1.04A 2hrcA-5n8oA:
undetectable		 2hrcA-5n8oA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omt NUCB

(Bacillus
licheniformis) 		no annotation 4 ARG A  77
PRO A  43
VAL A 124
TRP A 123
 None
 1.33A 2hrcA-5omtA:
undetectable		 2hrcA-5omtA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta9 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF04616
(Glyco_hydro_43) 		4 ARG A 383
LEU A  76
PRO A 166
VAL A 103
 None
 0.97A 2hrcA-5ta9A:
undetectable		 2hrcA-5ta9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucv PROBABLE GTP-BINDING
PROTEIN ENGB

(Neisseria
gonorrhoeae) 		PF01926
(MMR_HSR1) 		4 LEU A  43
PRO A 136
VAL A 192
TRP A 195
 None
 1.36A 2hrcA-5ucvA:
undetectable		 2hrcA-5ucvA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 4 LEU A 192
PRO A 331
VAL A 343
TRP A 340
 None
MPD  A1201 ( 4.8A)
None
None
 1.33A 2hrcA-5vawA:
undetectable		 2hrcA-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)

(Sorghum bicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 141
PRO A  64
VAL A  66
MET A  62
 None
 1.26A 2hrcA-5vktA:
undetectable		 2hrcA-5vktA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whg PROTEIN VMS1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 284
LEU A 320
VAL A 327
TRP A 331
 None
 1.27A 2hrcA-5whgA:
undetectable		 2hrcA-5whgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 MET A  21
LEU A  41
VAL A 153
TRP A  15
 None
 1.30A 2hrcA-5ybbA:
undetectable		 2hrcA-5ybbA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 4 MET A 380
LEU A 437
PRO A 409
MET A 406
 None
 1.04A 2hrcA-6cz4A:
undetectable		 2hrcA-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd 26S PROTEASOME
SUBUNIT S5A

(Rattus
norvegicus) 		no annotation 4 ARG W 130
LEU W 127
VAL W 138
MET W   7
 None
 1.37A 2hrcA-6epdW:
3.1		 2hrcA-6epdW:
undetectable