SIMILAR PATTERNS OF AMINO ACIDS FOR 2HRC_A_CHDA701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n U2A'

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A  87
LEU A  66
ILE A  79
LEU A  26
VAL A  71
 None
 1.16A 2hrcA-1a9nA:
undetectable		 2hrcA-1a9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 LEU A 330
LEU A 322
ILE A  25
LEU A 308
VAL A 318
 None
 1.06A 2hrcA-1c3rA:
undetectable		 2hrcA-1c3rA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		5 SER A 121
HIS A 183
LEU A 185
PRO A 186
TRP A 230
 MP1  A 800 (-3.4A)
MP1  A 800 (-3.6A)
MP1  A 800 (-4.8A)
MP1  A 800 (-4.6A)
None
 1.00A 2hrcA-1c9eA:
34.1		 2hrcA-1c9eA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fta FRUCTOSE-1,6-BISPHOS
PHATASE

(Homo sapiens) 		PF00316
(FBPase) 		5 LEU A 173
PHE A 193
LEU A 175
ILE A  44
LEU A  30
 None
None
None
None
AMP  A 338 ( 4.2A)
 1.21A 2hrcA-1ftaA:
undetectable		 2hrcA-1ftaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 LEU A 164
LEU A  85
LEU A 151
PRO A 150
VAL A 121
 None
 1.22A 2hrcA-1gz0A:
1.3		 2hrcA-1gz0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A  97
PHE A 101
SER A 239
PRO A 289
VAL A 269
 None
 1.10A 2hrcA-1k86A:
2.1		 2hrcA-1k86A:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 ILE A 313
SER A 167
PRO A 238
VAL A 241
TRP A 282
 None
 0.99A 2hrcA-1lbqA:
48.4		 2hrcA-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 ILE A 313
SER A 169
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 1.38A 2hrcA-1lbqA:
48.4		 2hrcA-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		10 LEU A  62
PHE A  63
ILE A  91
SER A 169
HIS A 235
LEU A 237
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 0.38A 2hrcA-1lbqA:
48.4		 2hrcA-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		7 MET A  46
SER A 167
HIS A 235
LEU A 237
PRO A 238
VAL A 241
TRP A 282
 None
 1.46A 2hrcA-1lbqA:
48.4		 2hrcA-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		7 MET A  46
SER A 169
HIS A 235
LEU A 237
PRO A 238
VAL A 241
TRP A 282
 None
 0.95A 2hrcA-1lbqA:
48.4		 2hrcA-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		7 PHE A  63
LEU A  68
SER A 169
HIS A 235
LEU A 237
VAL A 277
TRP A 282
 None
 1.10A 2hrcA-1lbqA:
48.4		 2hrcA-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pff METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  98
LEU A 104
ILE A 240
SER A 106
LEU A 110
 None
 1.20A 2hrcA-1pffA:
0.7		 2hrcA-1pffA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 LEU A  30
LEU A 136
ILE A  44
LEU A 167
VAL A 163
 None
 1.07A 2hrcA-1pujA:
undetectable		 2hrcA-1pujA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A  64
PHE A  55
ILE A 169
VAL A  27
VAL A 177
 None
 1.20A 2hrcA-1qi7A:
undetectable		 2hrcA-1qi7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 291
PHE A 287
LEU A 292
ILE A 255
LEU A  60
 None
 1.18A 2hrcA-1vmaA:
undetectable		 2hrcA-1vmaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 MET A 205
LEU A 201
PHE A 197
LEU A  34
ILE A 106
 None
 1.21A 2hrcA-1vqzA:
undetectable		 2hrcA-1vqzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		5 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.12A 2hrcA-1yirA:
undetectable		 2hrcA-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A  39
PHE A  67
LEU A  52
LEU A  29
VAL A  34
 None
 1.22A 2hrcA-1yrgA:
undetectable		 2hrcA-1yrgA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4w HYPOTHETICAL
PROTEIN, CONSERVED

(Leishmania
major) 		PF08950
(DUF1861) 		5 PHE A 309
ILE A  89
LEU A  81
PRO A  84
VAL A  60
 None
 1.21A 2hrcA-2b4wA:
undetectable		 2hrcA-2b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2x 2-DEOXY-SCYLLO-INOSO
SE SYNTHASE

(Bacillus
circulans) 		PF01761
(DHQ_synthase) 		5 LEU A 368
LEU A 301
ILE A 364
LEU A 189
VAL A 185
 None
 1.16A 2hrcA-2d2xA:
undetectable		 2hrcA-2d2xA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 MET A 752
LEU A 748
LEU A 370
ILE A 728
LEU A 161
 None
 1.14A 2hrcA-2eaeA:
undetectable		 2hrcA-2eaeA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 LEU A 103
PHE A 124
ILE A 158
LEU A  78
PRO A  81
 None
 1.16A 2hrcA-2fi1A:
1.6		 2hrcA-2fi1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 LEU A  23
LEU A  60
ILE A 180
LEU A  80
VAL A  86
 None
 1.22A 2hrcA-2fmtA:
undetectable		 2hrcA-2fmtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		5 ILE A  55
SER A  70
LEU A 201
PRO A 192
VAL A 222
 None
None
None
None
SAH  A 301 (-4.5A)
 1.19A 2hrcA-2pbfA:
undetectable		 2hrcA-2pbfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		5 LEU B 263
LEU B 256
ILE B 457
LEU B 145
VAL B 149
 None
 1.11A 2hrcA-2pffB:
undetectable		 2hrcA-2pffB:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjg PUTATIVE ALDOLASE
MJ0400

(Methanocaldococcus
jannaschii) 		PF01791
(DeoC) 		5 MET A 146
LEU A  86
SER A 117
LEU A  63
VAL A  69
 None
 1.11A 2hrcA-2qjgA:
undetectable		 2hrcA-2qjgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		6 LEU G1960
LEU G1904
ILE G1967
SER G1850
PRO G1975
VAL G1842
 None
 1.44A 2hrcA-2uv8G:
undetectable		 2hrcA-2uv8G:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		5 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 1.00A 2hrcA-2w3wA:
undetectable		 2hrcA-2w3wA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 154
LEU A 151
ILE A 139
LEU A 369
VAL A  67
 None
None
DIF  A1374 (-4.7A)
None
None
 0.95A 2hrcA-2wekA:
undetectable		 2hrcA-2wekA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv7 CG10997-PA

(Drosophila
melanogaster) 		no annotation 5 LEU A 132
LEU A 147
ILE A 227
LEU A 201
PRO A 198
 None
 1.15A 2hrcA-2yv7A:
undetectable		 2hrcA-2yv7A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.94A 2hrcA-2z63A:
undetectable		 2hrcA-2z63A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 MET A 243
LEU A 277
LEU A 280
LEU A 231
VAL A 255
 None
 1.02A 2hrcA-2z63A:
undetectable		 2hrcA-2z63A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.91A 2hrcA-3a8kA:
undetectable		 2hrcA-3a8kA:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 ILE A 342
SER A 195
PRO A 266
VAL A 269
TRP A 310
 None
None
CHD  A   2 ( 4.5A)
None
CHD  A   2 (-4.7A)
 1.02A 2hrcA-3aqiA:
60.0		 2hrcA-3aqiA:
99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		12 MET A  76
LEU A  92
PHE A  93
LEU A  98
ILE A 119
SER A 197
HIS A 263
LEU A 265
PRO A 266
VAL A 269
VAL A 305
TRP A 310
 CHD  A   1 ( 3.8A)
CHD  A   1 (-4.8A)
CHD  A   1 ( 4.7A)
CHD  A   1 (-4.3A)
None
CHD  A   1 (-3.0A)
CHD  A   1 (-4.3A)
None
CHD  A   2 ( 4.5A)
None
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 0.56A 2hrcA-3aqiA:
60.0		 2hrcA-3aqiA:
99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		6 SER A 195
HIS A 263
LEU A 265
PRO A 266
VAL A 269
TRP A 310
 None
CHD  A   1 (-4.3A)
None
CHD  A   2 ( 4.5A)
None
CHD  A   2 (-4.7A)
 1.14A 2hrcA-3aqiA:
60.0		 2hrcA-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		5 LEU A 340
LEU A 279
LEU A 247
VAL A 250
VAL A 386
 HEM  A 450 (-4.9A)
None
None
None
None
 1.22A 2hrcA-3bdzA:
undetectable		 2hrcA-3bdzA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvc UNCHARACTERIZED
PROTEIN ISM_01780

(Roseovarius
nubinhibens) 		PF13759
(2OG-FeII_Oxy_5) 		5 LEU A 105
LEU A  80
ILE A  38
SER A  79
VAL A 132
 None
 1.13A 2hrcA-3bvcA:
undetectable		 2hrcA-3bvcA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnc FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		5 LEU A 188
LEU A 186
ILE A 197
SER A 239
VAL A 305
 None
 1.12A 2hrcA-3cncA:
undetectable		 2hrcA-3cncA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		6 MET A 243
LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 1.05A 2hrcA-3fxiA:
undetectable		 2hrcA-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 285
ILE A 273
LEU A 113
PRO A 153
VAL A 156
 None
 1.23A 2hrcA-3gp0A:
undetectable		 2hrcA-3gp0A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 LEU A 496
ILE A 510
LEU A 121
VAL A 668
VAL A 519
 None
 1.20A 2hrcA-3jb9A:
undetectable		 2hrcA-3jb9A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		5 LEU A1300
PHE A1380
LEU A1388
ILE A1285
LEU A1362
 None
 1.21A 2hrcA-3jroA:
undetectable		 2hrcA-3jroA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.19A 2hrcA-3l6aA:
undetectable		 2hrcA-3l6aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lly AGGLUTININ ALPHA
CHAIN

(Maclura
pomifera) 		PF01419
(Jacalin) 		5 LEU A  28
LEU A 124
ILE A  12
VAL A  72
VAL A  68
 None
 0.97A 2hrcA-3llyA:
undetectable		 2hrcA-3llyA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.16A 2hrcA-3m1mA:
undetectable		 2hrcA-3m1mA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 MET A  26
LEU A 284
PHE A 285
VAL A  10
VAL A 251
 None
 1.00A 2hrcA-3mc2A:
undetectable		 2hrcA-3mc2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n91 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735) 		5 LEU A 133
PHE A 137
LEU A 152
PRO A 151
VAL A  86
 None
 1.10A 2hrcA-3n91A:
undetectable		 2hrcA-3n91A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR

(Schistosoma
haematobium) 		PF00079
(Serpin) 		5 LEU A  53
LEU A 318
ILE A 137
SER A 324
VAL A 123
 None
 1.17A 2hrcA-3stoA:
undetectable		 2hrcA-3stoA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 LEU B 104
LEU B 115
ILE B 207
LEU B 168
VAL B  17
 None
 1.20A 2hrcA-3ufxB:
3.7		 2hrcA-3ufxB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
ILE A 550
VAL A 380
VAL A 458
 None
 1.17A 2hrcA-3v4oA:
undetectable		 2hrcA-3v4oA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 MET A 307
LEU A 260
LEU A 283
VAL A 274
VAL A  17
 None
 1.00A 2hrcA-3vcyA:
undetectable		 2hrcA-3vcyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 224
LEU A 221
ILE A 231
LEU A 195
VAL A 189
 None
 1.11A 2hrcA-3wpeA:
undetectable		 2hrcA-3wpeA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.13A 2hrcA-3zyiA:
undetectable		 2hrcA-3zyiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 LEU A 665
LEU A 669
ILE A 658
SER A 672
LEU A 740
 None
 1.13A 2hrcA-4a01A:
undetectable		 2hrcA-4a01A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		5 LEU A 280
LEU A  85
ILE A 252
LEU A 145
VAL A  68
 None
 1.22A 2hrcA-4a9aA:
3.5		 2hrcA-4a9aA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 LEU A 253
PHE A 225
ILE A 289
PRO A 236
VAL A 295
 None
 1.23A 2hrcA-4booA:
undetectable		 2hrcA-4booA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 263
LEU A 277
LEU A 269
ILE A 284
SER A 268
 None
 1.18A 2hrcA-4eutA:
undetectable		 2hrcA-4eutA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 263
LEU A 277
LEU A 269
ILE A 284
SER A 268
 None
 1.22A 2hrcA-4euuA:
undetectable		 2hrcA-4euuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 CULLIN-1
GLOMULIN

(Homo sapiens;
Homo sapiens) 		PF00888
(Cullin)
PF08568
(Kinetochor_Ybp2) 		5 LEU A 531
ILE A 537
SER A 528
HIS A 524
LEU E 555
 None
 1.18A 2hrcA-4f52A:
undetectable		 2hrcA-4f52A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 LEU A 182
LEU A  72
ILE A 322
LEU A 130
VAL A  58
 None
 1.20A 2hrcA-4h59A:
undetectable		 2hrcA-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
 None
 1.17A 2hrcA-4hq1A:
undetectable		 2hrcA-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		6 LEU A 515
PHE A 511
LEU A 369
ILE A 550
VAL A 380
VAL A 458
 None
 1.35A 2hrcA-4i1pA:
undetectable		 2hrcA-4i1pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k82 LV-RANASPUMIN
(LV-RSN-1)

(Leptodactylus
vastus) 		no annotation 5 LEU A 198
PHE A 191
LEU A 201
LEU A 138
VAL A 145
 None
 1.03A 2hrcA-4k82A:
undetectable		 2hrcA-4k82A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		5 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.23A 2hrcA-4lctA:
undetectable		 2hrcA-4lctA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU A1305
PHE A1342
LEU A1353
LEU A1260
VAL A1331
 None
 1.21A 2hrcA-4ll6A:
undetectable		 2hrcA-4ll6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.18A 2hrcA-4mn8A:
undetectable		 2hrcA-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.19A 2hrcA-4mnaA:
undetectable		 2hrcA-4mnaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A1167
ILE A1096
LEU A 946
VAL A 949
VAL A1000
 None
 1.22A 2hrcA-4n78A:
undetectable		 2hrcA-4n78A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		5 LEU A 209
PHE A 173
LEU A 170
ILE A 218
SER A 164
 None
 1.21A 2hrcA-4pmzA:
undetectable		 2hrcA-4pmzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 LEU A 183
LEU A 179
ILE A 143
LEU A 195
VAL A 164
 None
 1.11A 2hrcA-4tx8A:
undetectable		 2hrcA-4tx8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.22A 2hrcA-4z0cA:
undetectable		 2hrcA-4z0cA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		5 LEU A 144
LEU A 183
PRO A 276
VAL A 277
VAL A  38
 None
 1.20A 2hrcA-4zrqA:
undetectable		 2hrcA-4zrqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4p REPEBODY

(synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A  70
LEU A  92
ILE A  22
LEU A 107
VAL A  65
 None
 1.14A 2hrcA-5b4pA:
undetectable		 2hrcA-5b4pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.15A 2hrcA-5cniA:
2.9		 2hrcA-5cniA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d17 TRANSPOSON TN7
TRANSPOSITION
PROTEIN TNSE

(Escherichia
coli) 		no annotation 5 LEU A 399
LEU A 514
PRO A 511
VAL A 519
VAL A 508
 None
 1.11A 2hrcA-5d17A:
undetectable		 2hrcA-5d17A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		5 LEU B  26
PHE B  28
LEU B 218
ILE B  64
SER B  44
 None
None
None
None
ANP  B 301 (-3.4A)
 1.20A 2hrcA-5d3mB:
undetectable		 2hrcA-5d3mB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddv 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		5 LEU A 169
PHE A 164
LEU A  91
PRO A   8
VAL A  52
 None
 1.16A 2hrcA-5ddvA:
undetectable		 2hrcA-5ddvA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3

(Mus musculus) 		PF02338
(OTU) 		5 LEU A 275
LEU A 303
ILE A 210
LEU A 236
PRO A 235
 None
 1.18A 2hrcA-5dq6A:
undetectable		 2hrcA-5dq6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		5 LEU A  43
ILE A  92
LEU A 171
VAL A 168
VAL A 142
 None
GOL  A 522 ( 4.4A)
None
None
None
 1.11A 2hrcA-5fcaA:
undetectable		 2hrcA-5fcaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1

(Homo sapiens) 		no annotation 5 LEU A  81
LEU A  85
HIS A  42
LEU A  10
VAL A  64
 MLY  A  78 ( 4.3A)
None
None
None
None
 1.20A 2hrcA-5forA:
undetectable		 2hrcA-5forA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		5 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.21A 2hrcA-5fqlA:
undetectable		 2hrcA-5fqlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		5 LEU A 117
PHE A 114
LEU A 121
LEU A  52
VAL A  89
 None
 1.23A 2hrcA-5hosA:
undetectable		 2hrcA-5hosA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum) 		no annotation 5 LEU A 236
PHE A 240
LEU A 290
ILE A 267
SER A 196
 None
 1.23A 2hrcA-5jkqA:
undetectable		 2hrcA-5jkqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.17A 2hrcA-5kznA:
4.0		 2hrcA-5kznA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 MET A 161
LEU A 187
LEU A 127
ILE A 220
VAL A 177
 None
 1.18A 2hrcA-5lcwA:
undetectable		 2hrcA-5lcwA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC

(Spinacia
oleracea;
Spinacia
oleracea) 		PF00276
(Ribosomal_L23)
PF00831
(Ribosomal_L29) 		5 LEU Z  92
ILE V 147
LEU Z 152
PRO Z 149
VAL Z 146
 None
 1.11A 2hrcA-5mlcZ:
undetectable		 2hrcA-5mlcZ:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 5 LEU A  95
PHE A 147
ILE A  89
SER A  43
VAL A  38
 None
 1.23A 2hrcA-5ol0A:
undetectable		 2hrcA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 MET A 307
LEU A 260
LEU A 283
VAL A 274
VAL A  16
 None
 1.04A 2hrcA-5u4hA:
undetectable		 2hrcA-5u4hA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.21A 2hrcA-5vl1A:
undetectable		 2hrcA-5vl1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 5 ILE A   5
LEU A 359
PRO A 360
VAL A  21
TRP A  20
 None
 1.15A 2hrcA-5vqdA:
undetectable		 2hrcA-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 341
LEU A 331
ILE A 358
LEU A 260
VAL A 254
 None
 1.03A 2hrcA-5wjcA:
undetectable		 2hrcA-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 5 MET A 285
LEU A 252
LEU A 190
PRO A 167
VAL A 165
 None
 1.22A 2hrcA-5x7nA:
undetectable		 2hrcA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 LEU A 225
LEU A 222
ILE A 232
LEU A 196
VAL A 190
 None
 1.04A 2hrcA-5y3jA:
undetectable		 2hrcA-5y3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 5 LEU A 134
PRO A 135
VAL A 138
VAL A  87
TRP A 214
 None
 1.23A 2hrcA-5y4gA:
undetectable		 2hrcA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 LEU A 225
LEU A 222
ILE A 232
LEU A 196
VAL A 190
 None
 1.03A 2hrcA-5zlnA:
undetectable		 2hrcA-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwe PUTATIVE FIMBRIAL
ASSOCIATED
SORTASE-LIKE PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 5 LEU A 172
LEU A 232
ILE A 114
LEU A 207
VAL A 156
 None
 1.15A 2hrcA-6bweA:
undetectable		 2hrcA-6bweA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 MET A 495
LEU A 518
LEU A 522
LEU A 437
VAL A 399
 None
 1.06A 2hrcA-6f5dA:
undetectable		 2hrcA-6f5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE

(Homo sapiens) 		no annotation 5 LEU A  70
PHE A  66
ILE A 229
VAL A 139
VAL A 265
 None
 1.17A 2hrcA-6fm9A:
undetectable		 2hrcA-6fm9A:
undetectable