SIMILAR PATTERNS OF AMINO ACIDS FOR 2HKK_A_ALEA300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae)
PF00450
(Peptidase_S10)
4 ASN A 212
HIS A 448
ASN A 379
ILE A 395
None
1.23A 2hkkA-1ac5A:
undetectable
2hkkA-1ac5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0b INTERNALIN B

(Listeria
monocytogenes)
PF12354
(Internalin_N)
PF12799
(LRR_4)
4 ASN A  99
ASN A  76
ILE A  38
GLN A  72
None
1.24A 2hkkA-1d0bA:
undetectable
2hkkA-1d0bA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
4 ASN A 368
ILE A 375
GLN A 371
THR A  37
None
1.27A 2hkkA-1j3uA:
undetectable
2hkkA-1j3uA:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII


(Homo sapiens)
PF00194
(Carb_anhydrase)
4 ASN A  62
HIS A  64
GLN A  92
THR A 200
None
None
AZM  A1400 (-3.2A)
AZM  A1400 (-3.3A)
0.69A 2hkkA-1jd0A:
36.3
2hkkA-1jd0A:
36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
4 HIS A2753
ASN A2747
ILE A2539
GLN A2577
None
1.23A 2hkkA-1js8A:
undetectable
2hkkA-1js8A:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae)
PF00194
(Carb_anhydrase)
4 ASN A  64
HIS A  66
GLN A  90
THR A 178
BME  A 303 (-4.7A)
BME  A 303 (-3.6A)
None
AZI  A 305 ( 4.2A)
0.36A 2hkkA-1kopA:
29.5
2hkkA-1kopA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens)
PF00023
(Ank)
PF12796
(Ank_2)
4 ASN E 180
HIS E 184
ASN E 145
ILE E 120
None
1.14A 2hkkA-1nfiE:
undetectable
2hkkA-1nfiE:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii)
PF00331
(Glyco_hydro_10)
4 ASN A 170
HIS A  80
GLN A 232
THR A  41
None
1.22A 2hkkA-1nq6A:
undetectable
2hkkA-1nq6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p99 HYPOTHETICAL PROTEIN
PG110


(Staphylococcus
aureus)
PF03180
(Lipoprotein_9)
4 ASN A  90
ILE A 239
GLN A  93
THR A 108
None
1.14A 2hkkA-1p99A:
undetectable
2hkkA-1p99A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE


(Sus scrofa)
PF02971
(FTCD)
PF07837
(FTCD_N)
4 HIS A  82
ASN A 186
GLN A 268
THR A  44
GOL  A 480 ( 4.1A)
FON  A 330 (-4.0A)
FON  A 330 (-3.0A)
FON  A 330 (-3.1A)
1.21A 2hkkA-1qd1A:
undetectable
2hkkA-1qd1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
4 ASN A 337
ASN A 342
ILE A 435
GLN A 345
None
1.20A 2hkkA-1qhoA:
undetectable
2hkkA-1qhoA:
17.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV


(Mus musculus)
PF00194
(Carb_anhydrase)
4 ASN A  62
HIS A  64
GLN A  92
THR A 200
None
None
AZM  A 400 (-4.3A)
AZM  A 400 (-3.6A)
0.81A 2hkkA-1rj6A:
37.1
2hkkA-1rj6A:
37.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5r LUKS-PV

(Staphylococcus
phage PVL)
PF07968
(Leukocidin)
4 ASN A 262
ASN A 233
ILE A 158
GLN A  77
None
0.71A 2hkkA-1t5rA:
undetectable
2hkkA-1t5rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF01039
(Carboxyl_trans)
4 ASN A1587
ASN A1624
ILE A1755
THR A1726
None
1.13A 2hkkA-1uyvA:
undetectable
2hkkA-1uyvA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE


(Serratia
marcescens)
PF00561
(Abhydrolase_1)
4 ASN A  86
HIS A 234
ILE A  43
GLN A  71
None
1.25A 2hkkA-1x2bA:
undetectable
2hkkA-1x2bA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
4 ASN A 101
ASN A  97
GLN A 494
THR A 487
None
1.27A 2hkkA-1ygpA:
undetectable
2hkkA-1ygpA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 ASN A 541
HIS A 505
ASN A 474
GLN A 476
None
1.12A 2hkkA-2ag1A:
undetectable
2hkkA-2ag1A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Bacillus
subtilis)
PF01182
(Glucosamine_iso)
4 ASN A 158
ASN A 136
ILE A 133
THR A 146
None
1.23A 2hkkA-2bkxA:
undetectable
2hkkA-2bkxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT


(Hyphomicrobium
denitrificans)
PF01011
(PQQ)
PF13360
(PQQ_2)
4 ASN A  24
ASN A  20
ILE A   5
THR A  28
None
1.26A 2hkkA-2d0vA:
undetectable
2hkkA-2d0vA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei9 NON-LTR
RETROTRANSPOSON
R1BMKS ORF2 PROTEIN


(Bombyx mori)
PF14529
(Exo_endo_phos_2)
4 ASN A 172
ILE A  16
GLN A  15
THR A 131
None
1.06A 2hkkA-2ei9A:
undetectable
2hkkA-2ei9A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evv HYPOTHETICAL PROTEIN
HP0218


(Helicobacter
pylori)
PF01161
(PBP)
4 ASN A  98
ILE A  93
GLN A  95
THR A  36
None
1.15A 2hkkA-2evvA:
undetectable
2hkkA-2evvA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG)
PF05199
(GMC_oxred_C)
4 ASN A 585
HIS A 553
ILE A 603
THR A 319
None
1.26A 2hkkA-2f5vA:
undetectable
2hkkA-2f5vA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae)
PF05860
(Haemagg_act)
4 ASN A 380
ASN A 404
ILE A 411
GLN A 406
None
0.93A 2hkkA-2odlA:
undetectable
2hkkA-2odlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum)
PF13714
(PEP_mutase)
4 ASN A 110
ASN A 149
ILE A 173
THR A 209
SO4  A 255 (-3.8A)
None
None
GOL  A 264 ( 3.9A)
1.13A 2hkkA-2qiwA:
undetectable
2hkkA-2qiwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII


(Homo sapiens)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2)
4 ASN B2019
HIS B2082
ILE B1940
GLN B1874
NAG  B2431 ( 4.8A)
None
None
None
1.20A 2hkkA-2r7eB:
undetectable
2hkkA-2r7eB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII


(Homo sapiens)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2)
4 ASN B2019
HIS B2082
ILE B1940
GLN B1938
NAG  B2431 ( 4.8A)
None
None
NAG  B2431 (-3.4A)
1.19A 2hkkA-2r7eB:
undetectable
2hkkA-2r7eB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E


(Fusarium
graminearum)
PF02458
(Transferase)
4 ASN A 356
HIS A 355
ILE A 212
THR A   9
None
1.24A 2hkkA-2rkvA:
undetectable
2hkkA-2rkvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y


(Ruminiclostridium
thermocellum)
PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9)
4 ASN A 394
HIS A 276
GLN A 457
THR A 231
None
XYP  A1001 (-3.9A)
None
None
1.20A 2hkkA-2w5fA:
undetectable
2hkkA-2w5fA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqw INTERNALIN B

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
4 ASN A  99
ASN A  76
ILE A  38
GLN A  72
PEG  A1322 (-3.6A)
None
None
None
1.27A 2hkkA-2wqwA:
undetectable
2hkkA-2wqwA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E


(Bacteroides
thetaiotaomicron)
PF07971
(Glyco_hydro_92)
4 ASN A 194
ASN A  96
GLN A  90
THR A 100
None
GOL  A 803 (-4.6A)
None
None
1.27A 2hkkA-2ww2A:
undetectable
2hkkA-2ww2A:
16.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV


(Mus musculus)
PF00194
(Carb_anhydrase)
4 ASN A  62
HIS A  64
GLN A  92
THR A 200
None
0.35A 2hkkA-2zncA:
31.8
2hkkA-2zncA:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1


(Arabidopsis
thaliana)
PF07859
(Abhydrolase_3)
4 ASN A 327
HIS A 329
ASN A 326
THR A 318
None
1.17A 2hkkA-2zsiA:
undetectable
2hkkA-2zsiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii)
PF00677
(Lum_binding)
4 ASN A  82
ASN A  45
ILE A  12
THR A 171
None
1.20A 2hkkA-3a3gA:
undetectable
2hkkA-3a3gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii)
PF00677
(Lum_binding)
4 ASN A 141
ASN A  45
ILE A  26
THR A 171
None
1.14A 2hkkA-3a3gA:
undetectable
2hkkA-3a3gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
4 ASN A 110
HIS A 112
GLN A 161
THR A 261
None
0.33A 2hkkA-3b1bA:
25.4
2hkkA-3b1bA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE


(Trypanosoma
vivax)
PF01156
(IU_nuc_hydro)
4 ASN A  59
HIS A  58
ASN A 101
ILE A  95
None
1.16A 2hkkA-3b9gA:
undetectable
2hkkA-3b9gA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvm ENTEROTOXIN TYPE C-3

(Staphylococcus
aureus)
PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C)
4 ASN A 220
ILE A 161
GLN A 157
THR A  66
None
1.23A 2hkkA-3bvmA:
undetectable
2hkkA-3bvmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B


(Sulfolobus
solfataricus)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
4 ASN B 911
HIS B 913
ASN B 733
ILE B 892
None
1.16A 2hkkA-3hkzB:
undetectable
2hkkA-3hkzB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn3 PUTATIVE PERIPLASMIC
PROTEIN


(Wolinella
succinogenes)
PF12849
(PBP_like_2)
4 ASN A 198
ASN A  81
ILE A 174
THR A 123
None
None
None
GOL  A 262 (-4.0A)
1.21A 2hkkA-3kn3A:
undetectable
2hkkA-3kn3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kng SNOAB

(Streptomyces
nogalater)
PF03992
(ABM)
4 ASN A  63
HIS A  49
ASN A  18
THR A  36
None
1.21A 2hkkA-3kngA:
undetectable
2hkkA-3kngA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxx GTPASE IMAP FAMILY
MEMBER 4


(Homo sapiens)
PF04548
(AIG1)
4 HIS A  57
ASN A  48
ILE A  50
THR A  66
None
None
None
MG  A 402 (-2.9A)
1.17A 2hkkA-3lxxA:
undetectable
2hkkA-3lxxA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens)
PF00194
(Carb_anhydrase)
4 ASN A  62
HIS A  64
GLN A  92
THR A 200
None
None
AZM  A 264 (-4.1A)
AZM  A 264 (-3.5A)
0.44A 2hkkA-3ml5A:
43.1
2hkkA-3ml5A:
55.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1


(Arabidopsis
thaliana)
no annotation 4 ASN B 426
ASN B 392
ILE B 390
THR B 451
None
0.98A 2hkkA-3ogkB:
undetectable
2hkkA-3ogkB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1


(Mus musculus)
PF00784
(MyTH4)
4 HIS A1015
ILE A1045
GLN A1178
THR A1013
None
1.13A 2hkkA-3pvlA:
undetectable
2hkkA-3pvlA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 ASN A 433
ILE A 361
GLN A 365
THR A 142
None
1.24A 2hkkA-3qtpA:
undetectable
2hkkA-3qtpA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6y ASPARTASE

(Bacillus sp.
YM55-1)
PF00206
(Lyase_1)
4 ASN A 368
ILE A 375
GLN A 371
THR A  37
ASN  A 368 ( 0.6A)
ILE  A 375 ( 0.7A)
GLN  A 371 ( 0.6A)
THR  A  37 ( 0.8A)
1.26A 2hkkA-3r6yA:
undetectable
2hkkA-3r6yA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II


(Mycolicibacterium
smegmatis)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
4 ASN A 132
ASN A 111
ILE A  84
THR A 140
None
1.17A 2hkkA-3rd8A:
undetectable
2hkkA-3rd8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrp PROBABLE FUMARATE
HYDRATASE FUM


(Mycobacteroides
abscessus)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
4 ASN A 133
ASN A 110
ILE A  83
THR A 141
None
1.20A 2hkkA-3rrpA:
undetectable
2hkkA-3rrpA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI


(Bacillus
pumilus)
PF02384
(N6_Mtase)
PF15516
(BpuSI_N)
4 ASN A   7
ASN A  39
ILE A 163
GLN A 160
None
1.25A 2hkkA-3s1sA:
undetectable
2hkkA-3s1sA:
15.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens)
PF00194
(Carb_anhydrase)
4 ASN A  62
HIS A  64
GLN A  92
THR A 199
None
0.56A 2hkkA-3uyqA:
40.8
2hkkA-3uyqA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 ASN A1318
HIS A1315
ILE A1557
GLN A1638
None
1.27A 2hkkA-3va7A:
undetectable
2hkkA-3va7A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare)
PF02922
(CBM_48)
PF11852
(DUF3372)
4 ASN A 598
ASN A 540
ILE A 547
THR A 619
None
1.19A 2hkkA-4aioA:
undetectable
2hkkA-4aioA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II


(Mycobacterium
tuberculosis)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
4 ASN A 134
ASN A 113
ILE A  86
THR A 142
None
1.17A 2hkkA-4apbA:
undetectable
2hkkA-4apbA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7q RALF,
PROLINE/BETAINE
TRANSPORTER


(Legionella
pneumophila;
Rickettsia
prowazekii)
PF01369
(Sec7)
4 ASN A 207
ASN A 206
ILE A 294
GLN A 204
None
1.23A 2hkkA-4d7qA:
undetectable
2hkkA-4d7qA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT BETA


(Azotobacter
vinelandii)
PF00696
(AA_kinase)
4 HIS B  70
ILE B 266
GLN B 244
THR B  39
None
PO4  B 303 ( 4.3A)
None
None
1.09A 2hkkA-4f6tB:
undetectable
2hkkA-4f6tB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster)
PF04389
(Peptidase_M28)
4 ASN A 141
HIS A  40
ASN A 315
ILE A 220
None
1.20A 2hkkA-4f9uA:
undetectable
2hkkA-4f9uA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE


(Sulfurihydrogenibium
sp. YO3AOP1)
PF00194
(Carb_anhydrase)
4 ASN A  62
HIS A  64
GLN A  87
THR A 175
None
None
AZM  A 302 (-4.4A)
AZM  A 302 (-3.4A)
0.41A 2hkkA-4g7aA:
29.8
2hkkA-4g7aA:
34.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3


(Homo sapiens)
PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like)
4 ASN B 305
ILE B 250
GLN B 254
THR B 842
None
1.24A 2hkkA-4gnkB:
undetectable
2hkkA-4gnkB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE


(Sulfolobus
solfataricus)
PF01941
(AdoMet_Synthase)
4 ASN A 311
HIS A  59
ASN A 314
ILE A 349
None
1.16A 2hkkA-4hpvA:
undetectable
2hkkA-4hpvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib2 PUTATIVE LIPOPROTEIN

([Ruminococcus]
gnavus)
PF03180
(Lipoprotein_9)
4 ASN A  89
ILE A 237
GLN A  92
THR A 106
None
1.07A 2hkkA-4ib2A:
undetectable
2hkkA-4ib2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikn AP-3 COMPLEX SUBUNIT
MU-1


(Rattus
norvegicus)
PF00928
(Adap_comp_sub)
4 HIS A 313
ASN A 374
ILE A 190
GLN A 415
HIS  A 313 ( 1.0A)
ASN  A 374 ( 0.6A)
ILE  A 190 ( 0.7A)
GLN  A 415 ( 0.6A)
1.16A 2hkkA-4iknA:
undetectable
2hkkA-4iknA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT


(Methanocaldococcus
jannaschii)
PF00330
(Aconitase)
4 HIS A 103
ASN A 387
ILE A 182
THR A 127
None
1.18A 2hkkA-4nqyA:
undetectable
2hkkA-4nqyA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli)
PF02395
(Peptidase_S6)
4 ASN A  73
ILE A 104
GLN A 105
THR A  54
None
1.26A 2hkkA-4om9A:
undetectable
2hkkA-4om9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2


(Mycobacterium
tuberculosis)
PF00557
(Peptidase_M24)
4 ASN A 144
ASN A 129
ILE A 127
THR A 167
None
1.22A 2hkkA-4ookA:
undetectable
2hkkA-4ookA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis)
PF00067
(p450)
4 ASN A  67
ASN A  96
ILE A 236
THR A 286
HEM  A 501 ( 4.8A)
None
2UO  A 502 (-4.1A)
2UO  A 502 ( 4.4A)
1.08A 2hkkA-4oqrA:
undetectable
2hkkA-4oqrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE


(Caldicellulosiruptor
bescii)
PF00331
(Glyco_hydro_10)
4 ASN A 182
HIS A  87
GLN A 244
THR A  48
None
BXP  A 401 (-3.9A)
None
None
1.18A 2hkkA-4pmdA:
undetectable
2hkkA-4pmdA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq8 DESIGNED PROTEIN
OR465


(synthetic
construct)
PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8)
4 ASN A  71
ASN A  48
ILE A  10
GLN A  44
None
1.26A 2hkkA-4pq8A:
undetectable
2hkkA-4pq8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct)
PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ASN A  71
ASN A  48
ILE A  10
GLN A  44
None
1.26A 2hkkA-4psjA:
undetectable
2hkkA-4psjA:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens)
PF00194
(Carb_anhydrase)
5 ASN A  62
ASN A  67
ILE A  91
GLN A  92
THR A 200
None
0.13A 2hkkA-4qk3A:
44.3
2hkkA-4qk3A:
95.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER


(Neisseria
gonorrhoeae)
PF03806
(ABG_transport)
4 ASN A 453
ASN A 410
ILE A 413
GLN A 419
None
1.21A 2hkkA-4r1iA:
undetectable
2hkkA-4r1iA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN


(synthetic
construct)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ASN A  63
ASN A  40
ILE A   2
GLN A  36
None
1.26A 2hkkA-4r5cA:
undetectable
2hkkA-4r5cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN


(synthetic
construct)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ASN A  63
ASN A  40
ILE A   2
GLN A  36
None
1.21A 2hkkA-4r5dA:
undetectable
2hkkA-4r5dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I


(synthetic
construct)
PF12354
(Internalin_N)
PF13855
(LRR_8)
4 ASN A  63
ASN A  40
ILE A   2
GLN A  36
None
1.20A 2hkkA-4r6fA:
undetectable
2hkkA-4r6fA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K


(synthetic
construct)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ASN A  63
ASN A  40
ILE A   2
GLN A  36
None
1.20A 2hkkA-4r6gA:
undetectable
2hkkA-4r6gA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium)
PF00150
(Cellulase)
4 ASN A 500
ASN A 447
ILE A 439
GLN A 443
XYS  A 618 (-3.1A)
XYS  A 618 (-3.4A)
None
XYS  A 618 ( 4.2A)
1.20A 2hkkA-4w8bA:
undetectable
2hkkA-4w8bA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8l ENDO-1,4-BETA-XYLANA
SE C


(Paenibacillus
barcinonensis)
PF00331
(Glyco_hydro_10)
4 ASN A 528
HIS A 420
GLN A 590
THR A 381
None
1.26A 2hkkA-4w8lA:
undetectable
2hkkA-4w8lA:
17.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)


(Sulfurihydrogenibium
azorense)
PF00194
(Carb_anhydrase)
4 ASN A  62
HIS A  64
GLN A  87
THR A 175
None
None
AZM  A 302 (-4.3A)
AZM  A 302 (-3.3A)
0.34A 2hkkA-4x5sA:
29.9
2hkkA-4x5sA:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY


(Hydrogenovibrio
crunogenus)
PF00194
(Carb_anhydrase)
4 ASN A 138
HIS A 140
GLN A 163
THR A 253
None
None
None
BCT  A 402 ( 4.4A)
0.38A 2hkkA-4xz5A:
29.4
2hkkA-4xz5A:
32.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE


(Geobacillus
stearothermophilus)
PF00232
(Glyco_hydro_1)
4 ASN A 299
ILE A 173
GLN A 170
THR A 121
None
None
BG6  A 501 (-3.0A)
None
1.21A 2hkkA-4zfmA:
undetectable
2hkkA-4zfmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3


(Acinetobacter
baumannii)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
4 HIS A 996
ILE A 928
GLN A 927
THR A1034
None
1.16A 2hkkA-4zxiA:
undetectable
2hkkA-4zxiA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA


(Methanothermobacter
marburgensis)
PF02241
(MCR_beta)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02783
(MCR_beta_N)
4 ASN A 479
HIS B 384
ASN A 458
ILE A 462
SMC  A 454 ( 3.6A)
SMC  A 454 ( 4.3A)
SMC  A 454 ( 3.9A)
None
1.11A 2hkkA-5a8rA:
undetectable
2hkkA-5a8rA:
18.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14


(Homo sapiens)
PF00194
(Carb_anhydrase)
4 ASN A  62
HIS A  64
GLN A  92
THR A 200
GOL  A 303 (-3.9A)
None
GOL  A 303 (-3.2A)
GOL  A 303 ( 3.5A)
0.36A 2hkkA-5cjfA:
36.6
2hkkA-5cjfA:
36.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
DNA POLYMERASE ALPHA
SUBUNIT B


(Homo sapiens)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N)
PF08996
(zf-DNA_Pol)
4 ASN C 549
HIS C 553
ILE C 728
THR D 309
None
1.04A 2hkkA-5exrC:
undetectable
2hkkA-5exrC:
12.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus)
PF00194
(Carb_anhydrase)
5 ASN X  61
HIS X  63
ASN X  66
GLN X  91
THR X 198
None
0.27A 2hkkA-5eztX:
44.2
2hkkA-5eztX:
80.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3v CAG8

(Helicobacter
pylori)
PF03524
(CagX)
4 HIS A  18
ILE A  24
GLN A  10
THR A  39
None
1.14A 2hkkA-5h3vA:
undetectable
2hkkA-5h3vA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkq CDII IMMUNITY
PROTEIN
CONTACT-DEPENDENT
INHIBITOR A


(Escherichia
coli)
PF14436
(EndoU_bacteria)
no annotation
4 ASN I   2
ASN I  28
ILE I  50
THR A 305
None
1.14A 2hkkA-5hkqI:
undetectable
2hkkA-5hkqI:
18.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum)
PF00194
(Carb_anhydrase)
4 ASN A  69
HIS A  71
GLN A  94
THR A 183
None
0.38A 2hkkA-5hpjA:
29.4
2hkkA-5hpjA:
35.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 ASN A1318
HIS A1315
ILE A1557
GLN A1638
None
1.21A 2hkkA-5i8iA:
undetectable
2hkkA-5i8iA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwd DNA POLYMERASE
PROCESSIVITY FACTOR


(Human
betaherpesvirus
5)
PF03325
(Herpes_PAP)
4 ASN A  89
ASN A  82
ILE A  80
THR A  94
None
0.94A 2hkkA-5iwdA:
undetectable
2hkkA-5iwdA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
4 ASN A 529
ILE A 502
GLN A 503
THR A 496
None
1.16A 2hkkA-5m5pA:
undetectable
2hkkA-5m5pA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT


(Homo sapiens)
no annotation 4 ASN A 638
ASN A 628
ILE A 667
THR A 633
None
1.08A 2hkkA-5nprA:
undetectable
2hkkA-5nprA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
no annotation 4 ASN C 476
HIS C 473
ASN C 449
ILE C 390
None
1.23A 2hkkA-5o4gC:
undetectable
2hkkA-5o4gC:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE


(Campylobacter
jejuni)
PF01041
(DegT_DnrJ_EryC1)
4 ASN A 185
HIS A 279
ASN A 248
ILE A 163
None
1.19A 2hkkA-5u24A:
undetectable
2hkkA-5u24A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER


(Camelina sativa)
PF01554
(MatE)
4 ASN A 405
ASN A 406
ILE A 262
THR A 386
None
1.01A 2hkkA-5xjjA:
undetectable
2hkkA-5xjjA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3x BETA-XYLANASE

(Caldicellulosiruptor
owensensis)
no annotation 4 ASN A 182
HIS A  86
GLN A 244
THR A  47
None
1.24A 2hkkA-5y3xA:
undetectable
2hkkA-5y3xA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens)
no annotation 4 HIS A 198
ASN A 201
ILE A  68
THR A 205
None
None
None
MG  A 728 (-3.6A)
1.07A 2hkkA-5yjhA:
undetectable
2hkkA-5yjhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze8 CYTOCHROME C552

(Thermochromatium
tepidum)
no annotation 4 ASN A 106
HIS A  38
ASN A 126
THR A 132
None
1.17A 2hkkA-5ze8A:
undetectable
2hkkA-5ze8A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina)
no annotation 4 ASN A  90
HIS A  92
GLN A 115
THR A 203
None
0.46A 2hkkA-6ekiA:
29.9
2hkkA-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens)
no annotation 4 ASN A  62
HIS A  64
GLN A  92
THR A 200
V14  A 302 (-3.4A)
None
V14  A 302 (-3.8A)
V14  A 302 (-3.5A)
0.40A 2hkkA-6fe1A:
33.6
2hkkA-6fe1A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-)
no annotation 4 ASN A 158
HIS A  95
ILE A 216
THR A 266
None
1.17A 2hkkA-6fhfA:
undetectable
2hkkA-6fhfA:
undetectable