SIMILAR PATTERNS OF AMINO ACIDS FOR 2HJH_B_NCAB901_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqm KINDLING FLUORESCENT
PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		4 ILE A  76
PRO A 190
PHE A  80
VAL A 147
 None
 1.40A 2hjhB-1xqmA:
undetectable		 2hjhB-1xqmA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzw GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN

(Heteractis
crispa) 		PF01353
(GFP) 		4 ILE A  77
PRO A 190
PHE A  81
VAL A 148
 None
 1.39A 2hjhB-1yzwA:
undetectable		 2hjhB-1yzwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9i GREEN FLUORESCENT
PROTEIN ASFP499

(Anemonia
sulcata) 		PF01353
(GFP) 		4 ILE A  76
PRO A 187
PHE A  80
VAL A 147
 None
 1.47A 2hjhB-2c9iA:
undetectable		 2hjhB-2c9iA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A  45
PRO A  42
PHE A  40
VAL A  33
 None
 1.23A 2hjhB-2cfmA:
undetectable		 2hjhB-2cfmA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9k PROTEIN MICAL-2

(Homo sapiens) 		PF00307
(CH) 		4 ILE A  82
PRO A  83
PHE A  73
VAL A  85
 None
 1.47A 2hjhB-2e9kA:
undetectable		 2hjhB-2e9kA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		4 ILE A 272
PRO A  67
PHE A 407
VAL A 246
 None
None
None
PMP  A 501 ( 4.5A)
 1.23A 2hjhB-2epjA:
0.3		 2hjhB-2epjA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		4 ILE A 181
PRO A 182
PHE A 263
VAL A 218
 None
None
None
NDP  A 501 ( 4.7A)
 1.16A 2hjhB-2gv8A:
1.3		 2hjhB-2gv8A:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 ILE A 271
PRO A 272
PHE A 274
VAL A 315
 NCA  A 900 (-4.6A)
NCA  A 900 (-4.1A)
NCA  A 900 ( 3.9A)
NCA  A 900 ( 4.5A)
 0.22A 2hjhB-2hjhA:
49.6		 2hjhB-2hjhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ILE A 413
PRO A 414
PHE A 464
VAL A 410
 None
 1.49A 2hjhB-2ongA:
undetectable		 2hjhB-2ongA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A1228
PRO A1231
PHE A1687
VAL A1220
 None
 1.50A 2hjhB-2pffA:
4.1		 2hjhB-2pffA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ILE A 462
PRO A 487
PHE A 450
VAL A 479
 None
 1.30A 2hjhB-2wtbA:
4.9		 2hjhB-2wtbA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 ILE A  82
PRO A  83
PHE A  62
VAL A 161
 None
 1.29A 2hjhB-2yn0A:
undetectable		 2hjhB-2yn0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn2 UNCHARACTERIZED
PROTEIN YNL108C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 ILE A  82
PRO A  83
PHE A  62
VAL A 160
 None
 1.45A 2hjhB-2yn2A:
undetectable		 2hjhB-2yn2A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 174
PRO A 175
PHE A 225
VAL A 206
 None
 1.22A 2hjhB-3abgA:
undetectable		 2hjhB-3abgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN

(Methanosarcina
acetivorans) 		PF00528
(BPD_transp_1) 		4 ILE C 101
PRO C 153
PHE C 149
VAL C 103
 None
 1.28A 2hjhB-3d31C:
undetectable		 2hjhB-3d31C:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvv UNCHARACTERIZED
PROTEIN

(Bordetella
pertussis) 		PF12710
(HAD) 		4 ILE A 125
PRO A 124
PHE A  84
VAL A 121
 None
 1.49A 2hjhB-3fvvA:
5.0		 2hjhB-3fvvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 495
PRO A 492
PHE A 503
VAL A 488
 None
 1.37A 2hjhB-3n6rA:
undetectable		 2hjhB-3n6rA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF08005
(PHR) 		4 ILE A 518
PRO A 519
PHE A 501
VAL A 521
 None
 1.31A 2hjhB-3no8A:
undetectable		 2hjhB-3no8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00171
(Aldedh) 		4 ILE A 181
PRO A 183
PHE A 223
VAL A 212
 ILE  A 181 ( 0.7A)
PRO  A 183 ( 1.1A)
PHE  A 223 ( 1.3A)
VAL  A 212 ( 0.6A)
 1.39A 2hjhB-3r64A:
undetectable		 2hjhB-3r64A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0m OXALATE
DECARBOXYLASE OXDC

(Bacillus
subtilis) 		PF00190
(Cupin_1) 		4 ILE A  75
PRO A 314
PHE A 303
VAL A  45
 None
 1.45A 2hjhB-3s0mA:
undetectable		 2hjhB-3s0mA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ILE A 232
PRO A 149
PHE A 485
VAL A 179
 None
 1.24A 2hjhB-3v4cA:
5.1		 2hjhB-3v4cA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eec STAL

(Streptomyces
toyocaensis) 		PF00685
(Sulfotransfer_1) 		4 ILE A 105
PRO A 106
PHE A 240
VAL A 110
 None
 1.09A 2hjhB-4eecA:
1.9		 2hjhB-4eecA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ILE A 585
PRO A 533
PHE A 490
VAL A 536
 None
 1.48A 2hjhB-4fysA:
undetectable		 2hjhB-4fysA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		4 ILE A 179
PRO A 176
PHE A 194
VAL A 172
 None
 1.09A 2hjhB-4g76A:
undetectable		 2hjhB-4g76A:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 ILE A 271
PRO A 272
PHE A 274
VAL A 315
 None
None
APR  A 602 (-3.5A)
None
 0.43A 2hjhB-4iaoA:
44.1		 2hjhB-4iaoA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 ILE A 231
PRO A 107
PHE A 110
VAL A 103
 None
 1.31A 2hjhB-4pbqA:
undetectable		 2hjhB-4pbqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Cellvibrio sp.
BR) 		PF13738
(Pyr_redox_3) 		4 ILE A 145
PRO A 146
PHE A 268
VAL A 178
 None
 1.20A 2hjhB-4usqA:
undetectable		 2hjhB-4usqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usr MONOOXYGENASE

(Pseudomonas
stutzeri) 		PF13738
(Pyr_redox_3) 		4 ILE A 137
PRO A 138
PHE A 257
VAL A 170
 None
GOL  A1356 ( 4.9A)
None
None
 1.29A 2hjhB-4usrA:
undetectable		 2hjhB-4usrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usr MONOOXYGENASE

(Pseudomonas
stutzeri) 		PF13738
(Pyr_redox_3) 		4 ILE A 137
PRO A 138
PHE A 260
VAL A 170
 None
GOL  A1356 ( 4.9A)
None
None
 1.27A 2hjhB-4usrA:
undetectable		 2hjhB-4usrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 446
PRO A 447
PHE A 450
VAL A 422
 None
 1.49A 2hjhB-5dgtA:
5.4		 2hjhB-5dgtA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2g DIAMINOPIMELATE
EPIMERASE

(Corynebacterium
glutamicum) 		PF01678
(DAP_epimerase) 		4 ILE A  20
PRO A  21
PHE A  90
VAL A  53
 None
 1.49A 2hjhB-5h2gA:
undetectable		 2hjhB-5h2gA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6u PROTEIN SIDEKICK-1

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ILE A 357
PRO A   6
PHE A   8
VAL A  72
 None
 1.48A 2hjhB-5k6uA:
undetectable		 2hjhB-5k6uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6z PROTEIN
SIDEKICK-2,PROTEIN
SIDEKICK-1 CHIMERA

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ILE A 179
PRO A 178
PHE A  95
VAL A 163
 None
 1.47A 2hjhB-5k6zA:
undetectable		 2hjhB-5k6zA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okz EXOSOME COMPLEX
COMPONENT MTR3

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		4 ILE F 173
PRO F 170
PHE F 116
VAL F 201
 None
 1.35A 2hjhB-5okzF:
undetectable		 2hjhB-5okzF:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 ILE A 841
PRO A 754
PHE A 668
VAL A 706
 None
 1.38A 2hjhB-5xgjA:
undetectable		 2hjhB-5xgjA:
undetectable