SIMILAR PATTERNS OF AMINO ACIDS FOR 2HH9_B_VIBB701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
LIGHT CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL L 197
SER L 178
SER L 163
ASN L 162
TYR L 141
 None
 1.35A 2hh9A-4hbcL:
0.0
2hh9B-4hbcL:
0.0		 2hh9A-4hbcL:
20.70
2hh9B-4hbcL:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL L 195
SER L 176
SER L 161
ASN L 160
TYR L 139
 None
 1.41A 2hh9A-4jo2L:
0.2
2hh9B-4jo2L:
0.2		 2hh9A-4jo2L:
22.12
2hh9B-4jo2L:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 VAL A 397
SER A 446
SER A 401
ASN A 402
ASP A 311
 None
 1.39A 2hh9A-4oj5A:
0.0
2hh9B-4oj5A:
0.0		 2hh9A-4oj5A:
18.60
2hh9B-4oj5A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztp LIGHT CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL L 195
SER L 176
SER L 161
ASN L 160
TYR L 139
 None
 1.31A 2hh9A-4ztpL:
0.0
2hh9B-4ztpL:
0.0		 2hh9A-4ztpL:
20.00
2hh9B-4ztpL:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsc FAB HOU24.B LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 195
SER B 176
SER B 161
ASN B 160
TYR B 139
 None
 1.30A 2hh9A-5dscB:
0.0
2hh9B-5dscB:
0.0		 2hh9A-5dscB:
19.17
2hh9B-5dscB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m63 L CHAIN OF FAB
NVS-1-19-5

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL L 222
SER L 203
SER L 188
ASN L 187
TYR L 166
 None
 1.30A 2hh9A-5m63L:
0.0
2hh9B-5m63L:
0.0		 2hh9A-5m63L:
21.39
2hh9B-5m63L:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xc4 ENDO-BETA-1,4-GLUCAN
ASE

(Ampullaria
crossean) 		no annotation 5 VAL A  86
TYR A 132
SER A 129
ASN A 128
ASP A   7
 None
 1.30A 2hh9A-5xc4A:
0.0
2hh9B-5xc4A:
0.0		 2hh9A-5xc4A:
12.87
2hh9B-5xc4A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjk -

(-) 		no annotation 5 VAL A 195
SER A 176
SER A 161
ASN A 160
TYR A 139
 None
 1.32A 2hh9A-6cjkA:
0.0
2hh9B-6cjkA:
0.0		 2hh9A-6cjkA:
undetectable
2hh9B-6cjkA:
undetectable