SIMILAR PATTERNS OF AMINO ACIDS FOR 2HH9_A_VIBA702

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
LIGHT CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR L 141
VAL L 197
SER L 178
SER L 163
ASN L 162
 None
 1.35A 2hh9A-4hbcL:
0.0
2hh9B-4hbcL:
0.0		 2hh9A-4hbcL:
20.70
2hh9B-4hbcL:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR L 139
VAL L 195
SER L 176
SER L 161
ASN L 160
 None
 1.41A 2hh9A-4jo2L:
0.2
2hh9B-4jo2L:
0.2		 2hh9A-4jo2L:
22.12
2hh9B-4jo2L:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 ASP A 311
VAL A 397
SER A 446
SER A 401
ASN A 402
 None
 1.38A 2hh9A-4oj5A:
0.0
2hh9B-4oj5A:
0.0		 2hh9A-4oj5A:
18.60
2hh9B-4oj5A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztp LIGHT CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR L 139
VAL L 195
SER L 176
SER L 161
ASN L 160
 None
 1.31A 2hh9A-4ztpL:
0.0
2hh9B-4ztpL:
0.0		 2hh9A-4ztpL:
20.00
2hh9B-4ztpL:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsc FAB HOU24.B LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR B 139
VAL B 195
SER B 176
SER B 161
ASN B 160
 None
 1.31A 2hh9A-5dscB:
0.0
2hh9B-5dscB:
0.0		 2hh9A-5dscB:
19.17
2hh9B-5dscB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m63 L CHAIN OF FAB
NVS-1-19-5

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR L 166
VAL L 222
SER L 203
SER L 188
ASN L 187
 None
 1.31A 2hh9A-5m63L:
0.0
2hh9B-5m63L:
0.0		 2hh9A-5m63L:
21.39
2hh9B-5m63L:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xc4 ENDO-BETA-1,4-GLUCAN
ASE

(Ampullaria
crossean) 		no annotation 5 ASP A   7
VAL A  86
TYR A 132
SER A 129
ASN A 128
 None
 1.31A 2hh9A-5xc4A:
0.0
2hh9B-5xc4A:
0.0		 2hh9A-5xc4A:
12.87
2hh9B-5xc4A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjk -

(-) 		no annotation 5 TYR A 139
VAL A 195
SER A 176
SER A 161
ASN A 160
 None
 1.32A 2hh9A-6cjkA:
0.0
2hh9B-6cjkA:
0.0		 2hh9A-6cjkA:
undetectable
2hh9B-6cjkA:
undetectable