SIMILAR PATTERNS OF AMINO ACIDS FOR 2HC4_A_VDXA525_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		4 LEU A 690
LEU A 691
ARG A 733
SER A 725
 None
 0.98A 2hc4A-1d2nA:
0.0		 2hc4A-1d2nA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9f LAMINA-ASSOCIATED
POLYPEPTIDE 2,
ISOFORM ALPHA

(Homo sapiens) 		PF03020
(LEM) 		4 LEU A  47
LEU A  44
ILE A  32
ARG A  37
 None
 0.96A 2hc4A-1h9fA:
undetectable		 2hc4A-1h9fA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 LEU A 410
ILE A 240
ARG A 405
TYR A 416
 None
 1.18A 2hc4A-1hg4A:
19.2		 2hc4A-1hg4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 LEU A 671
LEU A 672
ARG A 353
TYR A 639
 None
 1.23A 2hc4A-1kehA:
undetectable		 2hc4A-1kehA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 4 LEU A 100
LEU A  99
ARG A 299
SER A  91
 None
 1.05A 2hc4A-1nluA:
undetectable		 2hc4A-1nluA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6u SEC14-LIKE PROTEIN 2

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 LEU A  30
ILE A  71
ARG A 126
SER A  73
 None
 0.90A 2hc4A-1o6uA:
0.1		 2hc4A-1o6uA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)

(Bacillus
circulans) 		PF01374
(Glyco_hydro_46) 		4 LEU A  12
LEU A  15
ILE A 167
SER A 152
 None
 0.96A 2hc4A-1qgiA:
undetectable		 2hc4A-1qgiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 LEU A 410
LEU A 411
ILE A 431
SER A 488
 None
 0.95A 2hc4A-1qxpA:
0.0		 2hc4A-1qxpA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		4 LEU A 265
LEU A 231
ILE A 248
ARG A 216
 None
 1.09A 2hc4A-1ua4A:
0.0		 2hc4A-1ua4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A  29
LEU A 180
ILE A 166
SER A 145
 None
 0.97A 2hc4A-1wpqA:
undetectable		 2hc4A-1wpqA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 612
LEU A 602
ILE A 408
SER A 591
 None
 0.91A 2hc4A-1ybwA:
undetectable		 2hc4A-1ybwA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		4 LEU A 704
ILE A 929
ARG A 851
TYR A 921
 None
 1.15A 2hc4A-2aqxA:
undetectable		 2hc4A-2aqxA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU X  70
LEU X  65
SER X  56
TYR X  15
 None
 1.11A 2hc4A-2b5dX:
undetectable		 2hc4A-2b5dX:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 LEU A 256
ILE A 206
ARG A 248
SER A 249
 None
 1.14A 2hc4A-2bihA:
undetectable		 2hc4A-2bihA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 4 LEU A  54
ILE A 248
ARG A  75
SER A  76
 None
 1.06A 2hc4A-2cl2A:
undetectable		 2hc4A-2cl2A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkn 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Pseudomonas sp.
B-0831) 		PF13561
(adh_short_C2) 		4 LEU A  94
LEU A  93
ILE A  29
ARG A  58
 None
 1.21A 2hc4A-2dknA:
undetectable		 2hc4A-2dknA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN

(Lepidium
virginicum) 		PF00197
(Kunitz_legume) 		4 LEU A 160
ILE A  81
SER A  65
TYR A 139
 None
 1.01A 2hc4A-2dreA:
undetectable		 2hc4A-2dreA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		4 LEU A 298
LEU A 228
SER A 175
TYR A 301
 None
 1.25A 2hc4A-2e3zA:
undetectable		 2hc4A-2e3zA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eap LYMPHOCYTE CYTOSOLIC
PROTEIN 2

(Homo sapiens) 		PF07647
(SAM_2) 		4 LEU A  54
LEU A  56
ILE A  71
TYR A  30
 None
 1.25A 2hc4A-2eapA:
undetectable		 2hc4A-2eapA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 456
LEU A 453
ILE A 192
ARG A 203
 None
 0.66A 2hc4A-2h88A:
undetectable		 2hc4A-2h88A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqo PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00072
(Response_reg) 		4 LEU A   5
LEU A   4
ILE A  62
ARG A  61
 None
 1.15A 2hc4A-2hqoA:
undetectable		 2hc4A-2hqoA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 LEU A 289
LEU A 288
ARG A 302
TYR A 172
 None
 1.17A 2hc4A-2jjmA:
undetectable		 2hc4A-2jjmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llz UNCHARACTERIZED
PROTEIN YJDK

(Escherichia
coli) 		PF11080
(GhoS) 		4 LEU A  52
ILE A  72
ARG A  73
TYR A  34
 None
 1.24A 2hc4A-2llzA:
undetectable		 2hc4A-2llzA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		7 LEU A 223
LEU A 226
ILE A 267
ARG A 270
SER A 271
TRP A 282
TYR A 397
 None
VD4  A 500 ( 4.5A)
VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.0A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 3.7A)
None
 0.24A 2hc4A-2o4jA:
39.3		 2hc4A-2o4jA:
63.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnd V-SET AND
IMMUNOGLOBULIN
DOMAIN CONTAINING 4

(Mus musculus) 		PF07686
(V-set) 		4 LEU A  84
ILE A  58
ARG A  64
TYR A  92
 None
 1.22A 2hc4A-2pndA:
undetectable		 2hc4A-2pndA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU A  81
LEU A  78
SER A  38
TYR A 116
 None
 1.08A 2hc4A-2qriA:
undetectable		 2hc4A-2qriA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Mycobacterium
tuberculosis) 		PF00692
(dUTPase) 		4 LEU A   2
LEU A   3
ILE A  12
SER A  14
 None
 0.97A 2hc4A-2qxxA:
undetectable		 2hc4A-2qxxA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		4 LEU A 297
ILE A 153
SER A 155
TYR A 286
 None
None
HEM  A 600 (-3.6A)
None
 0.77A 2hc4A-2rchA:
1.5		 2hc4A-2rchA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 LEU A  61
LEU A  64
ARG A 306
SER A  70
 None
 1.11A 2hc4A-2y4oA:
undetectable		 2hc4A-2y4oA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 LEU A 335
LEU A 336
SER A 365
TYR A 443
 None
 1.05A 2hc4A-2yxlA:
2.3		 2hc4A-2yxlA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 519
LEU A 495
ILE A 466
SER A 441
 None
 1.19A 2hc4A-2z66A:
undetectable		 2hc4A-2z66A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		4 LEU A 104
LEU A 103
ILE A 314
TYR A 195
 None
 1.15A 2hc4A-2zm5A:
undetectable		 2hc4A-2zm5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 LEU A 682
LEU A 685
ILE A 693
TYR A 721
 None
 1.07A 2hc4A-3bdlA:
undetectable		 2hc4A-3bdlA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A 258
ILE A 337
SER A 387
TYR A 251
 None
None
None
TAD  A 500 (-4.1A)
 1.14A 2hc4A-3buzA:
undetectable		 2hc4A-3buzA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch4 PHOSPHOMEVALONATE
KINASE

(Homo sapiens) 		PF04275
(P-mevalo_kinase) 		4 LEU B  13
LEU B  12
SER B 190
TYR B 122
 None
 1.25A 2hc4A-3ch4B:
undetectable		 2hc4A-3ch4B:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 519
LEU A 495
ILE A 466
SER A 441
 None
 1.22A 2hc4A-3fxiA:
undetectable		 2hc4A-3fxiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LEU A 579
LEU A 576
ILE A 625
TYR A 603
 None
 1.17A 2hc4A-3jb9A:
undetectable		 2hc4A-3jb9A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo sapiens) 		PF02373
(JmjC) 		4 ILE A 233
ARG A 181
SER A 128
TYR A 240
 None
 1.18A 2hc4A-3ld8A:
undetectable		 2hc4A-3ld8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 LEU A 172
LEU A 169
ILE A 203
ARG A 162
 None
 1.19A 2hc4A-3nowA:
undetectable		 2hc4A-3nowA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p30 1281 FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  67
ILE H  51
SER H  35
TRP H  47
 None
 1.12A 2hc4A-3p30H:
undetectable		 2hc4A-3p30H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p77 MHC RFP-Y CLASS I
ALPHA CHAIN

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU A  79
LEU A  76
SER A  38
TYR A 112
 PGE  A 278 (-4.5A)
None
None
PGE  A 278 ( 4.3A)
 1.23A 2hc4A-3p77A:
undetectable		 2hc4A-3p77A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 LEU A 320
LEU A 322
ILE A 344
ARG A 374
 None
 1.24A 2hc4A-3qcwA:
undetectable		 2hc4A-3qcwA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU B1015
LEU B1012
ILE B1005
ARG B1063
 None
 1.14A 2hc4A-3qd2B:
undetectable		 2hc4A-3qd2B:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbg PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF12134
(PRP8_domainIV) 		4 LEU A2012
LEU A2011
ILE A2034
SER A2042
 None
 1.13A 2hc4A-3sbgA:
undetectable		 2hc4A-3sbgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sol TYPE II SECRETION
PATHWAY RELATED
PROTEIN

(Escherichia
coli) 		PF09691
(T2SS_PulS_OutS) 		4 LEU A 105
LEU A 104
ARG A  30
SER A  27
 None
 1.22A 2hc4A-3solA:
undetectable		 2hc4A-3solA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 LEU A 200
LEU A 201
ILE A 254
TRP A 237
 None
 1.22A 2hc4A-3t5bA:
undetectable		 2hc4A-3t5bA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 329
LEU A 325
ILE A 308
SER A 310
 None
 1.06A 2hc4A-3vwaA:
undetectable		 2hc4A-3vwaA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 227
LEU A 230
ILE A 271
ARG A 274
SER A 275
TRP A 286
TYR A 401
 None
ED9  A 501 ( 4.6A)
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-3.5A)
None
 0.39A 2hc4A-3wgpA:
37.7		 2hc4A-3wgpA:
64.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 414
ILE A 271
ARG A 274
SER A 275
 None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
 1.22A 2hc4A-3wgpA:
37.7		 2hc4A-3wgpA:
64.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A

(Methanosarcina
mazei) 		no annotation 4 LEU A 334
LEU A 333
ARG A 249
TYR A 263
 None
 1.20A 2hc4A-3wnbA:
undetectable		 2hc4A-3wnbA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		4 LEU A 222
ARG A 248
SER A 251
TYR A  97
 PLP  A 401 (-4.8A)
None
None
None
 1.17A 2hc4A-3x43A:
undetectable		 2hc4A-3x43A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		4 LEU A 272
LEU A 271
ILE A 241
TYR A 254
 None
 1.19A 2hc4A-3zgqA:
undetectable		 2hc4A-3zgqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		4 LEU A 578
LEU A 577
ARG A 359
SER A 358
 None
 1.11A 2hc4A-4aysA:
undetectable		 2hc4A-4aysA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A 207
LEU A 204
ILE A 197
ARG A 256
 None
 1.22A 2hc4A-4cfhA:
undetectable		 2hc4A-4cfhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		4 LEU A 292
LEU A 291
ILE A 187
SER A  96
 None
 1.22A 2hc4A-4doeA:
undetectable		 2hc4A-4doeA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Salmonella
enterica) 		PF12710
(HAD) 		4 LEU A 141
ILE A 119
ARG A 136
SER A 133
 None
 1.12A 2hc4A-4ezeA:
undetectable		 2hc4A-4ezeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 LEU A 599
ILE A 462
ARG A 594
SER A 591
 None
 0.77A 2hc4A-4fixA:
undetectable		 2hc4A-4fixA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A1016
LEU A1013
ILE A1006
ARG A1064
 None
 1.23A 2hc4A-4g34A:
undetectable		 2hc4A-4g34A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		4 LEU A 230
LEU A 227
ILE A 220
ARG A 279
 None
 1.15A 2hc4A-4j7bA:
undetectable		 2hc4A-4j7bA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jge RED FLUORESCENT
PROTEIN BLFP-R5

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		4 LEU A   9
LEU A  22
ILE A  15
SER A  47
 None
 1.23A 2hc4A-4jgeA:
undetectable		 2hc4A-4jgeA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kps HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 106
LEU A 109
ARG A 114
TYR A 258
 None
 0.92A 2hc4A-4kpsA:
undetectable		 2hc4A-4kpsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 116
LEU A 119
ARG A  48
TRP A  47
 None
 1.21A 2hc4A-4ktoA:
undetectable		 2hc4A-4ktoA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU C 193
LEU C 190
SER C 151
TYR C 225
 None
 1.11A 2hc4A-4lccC:
undetectable		 2hc4A-4lccC:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 LEU A 364
ILE A  95
ARG A  99
TRP A 352
 None
 1.02A 2hc4A-4o2zA:
undetectable		 2hc4A-4o2zA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 256
LEU A 253
ILE A 246
ARG A 303
 None
 1.20A 2hc4A-4o38A:
undetectable		 2hc4A-4o38A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		4 LEU A  37
ILE A  51
ARG A  54
SER A  55
 None
 0.94A 2hc4A-4ql6A:
undetectable		 2hc4A-4ql6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 LEU A 112
LEU A 111
ILE A 101
TYR A 145
 None
 1.13A 2hc4A-4rapA:
undetectable		 2hc4A-4rapA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 209
LEU A 206
ILE A 199
ARG A 258
 None
 1.18A 2hc4A-4redA:
undetectable		 2hc4A-4redA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A 209
LEU A 206
ILE A 199
ARG A 258
 None
 1.11A 2hc4A-4rewA:
undetectable		 2hc4A-4rewA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		4 LEU A 298
LEU A 301
ILE A 337
SER A 321
 None
 0.87A 2hc4A-4wzzA:
undetectable		 2hc4A-4wzzA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0a SHIKIMATE KINASE

(Acinetobacter
baumannii) 		PF01202
(SKI) 		4 LEU A 146
LEU A 149
ILE A  99
ARG A 105
 None
 1.24A 2hc4A-4y0aA:
undetectable		 2hc4A-4y0aA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycz NUP85

(Thermothelomyces
thermophila) 		PF07575
(Nucleopor_Nup85) 		4 LEU B 716
LEU B 413
ILE B 420
TRP B 443
 None
 1.16A 2hc4A-4yczB:
undetectable		 2hc4A-4yczB:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 LEU G 259
LEU G 453
ILE G 272
SER G 274
 None
 1.24A 2hc4A-4ydiG:
undetectable		 2hc4A-4ydiG:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF00955
(HCO3_cotransp) 		4 LEU A 527
ILE A 803
SER A 799
TYR A 519
 None
 1.15A 2hc4A-4yzfA:
undetectable		 2hc4A-4yzfA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a) 		4 LEU C 809
ILE C 891
SER C 889
TYR C 493
 None
 1.14A 2hc4A-5a6fC:
undetectable		 2hc4A-5a6fC:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 278
LEU A 279
ILE A 217
SER A 244
 None
None
None
FAD  A 701 (-2.5A)
 1.08A 2hc4A-5ahkA:
undetectable		 2hc4A-5ahkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab) 		4 LEU B 241
LEU B  40
ILE B  22
ARG B  56
 None
 1.18A 2hc4A-5bn4B:
undetectable		 2hc4A-5bn4B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU C   6
ILE C 131
ARG C 102
SER C 100
 None
 1.19A 2hc4A-5bntC:
undetectable		 2hc4A-5bntC:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		4 LEU A 538
LEU A 534
ILE A 495
ARG A 491
 None
 1.24A 2hc4A-5e26A:
undetectable		 2hc4A-5e26A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)

(Plasmodium
falciparum) 		no annotation 4 LEU A  92
LEU A  89
ILE A  81
TYR A  46
 None
 1.13A 2hc4A-5ewpA:
undetectable		 2hc4A-5ewpA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 LEU G 259
LEU G 453
ILE G 272
SER G 274
 None
 1.21A 2hc4A-5f9oG:
undetectable		 2hc4A-5f9oG:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 855
LEU A 858
SER A 831
TRP A 805
 None
 0.92A 2hc4A-5j6sA:
undetectable		 2hc4A-5j6sA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens) 		PF02275
(CBAH) 		4 LEU A 197
ILE A 234
ARG A 257
SER A  18
 None
 1.23A 2hc4A-5j9rA:
undetectable		 2hc4A-5j9rA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbl PROHEAD CORE PROTEIN
PROTEASE

(Escherichia
virus T4) 		PF03420
(Peptidase_S77) 		4 ILE A   8
ARG A 142
SER A 141
TRP A  11
 None
 1.02A 2hc4A-5jblA:
undetectable		 2hc4A-5jblA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9o STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 LEU A 707
LEU A 710
ILE A 718
TYR A 746
 None
 1.08A 2hc4A-5m9oA:
undetectable		 2hc4A-5m9oA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mv9 UNCONVENTIONAL
MYOSIN-VIIA

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		4 LEU A1858
ARG A1832
SER A1829
TYR A1814
 None
 1.19A 2hc4A-5mv9A:
undetectable		 2hc4A-5mv9A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okz EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		4 LEU H 194
LEU H 169
ARG H 187
SER H 140
 None
 1.05A 2hc4A-5okzH:
undetectable		 2hc4A-5okzH:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pwy NUCLEAR AUTOANTIGEN
SP-100

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A 782
ILE A 743
ARG A 746
TYR A 787
 None
 1.22A 2hc4A-5pwyA:
undetectable		 2hc4A-5pwyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo sapiens) 		PF00856
(SET) 		4 LEU A 320
LEU A 332
ILE A 223
TYR A 336
 None
None
None
SAM  A 401 (-4.8A)
 1.16A 2hc4A-5tegA:
undetectable		 2hc4A-5tegA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 LEU A1528
LEU A1560
ILE A1626
SER A1597
 None
 0.95A 2hc4A-5u1sA:
undetectable		 2hc4A-5u1sA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uba RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		4 LEU A 275
LEU A 271
ILE A 264
ARG A 179
 None
CL  A 401 (-4.2A)
None
None
 1.23A 2hc4A-5ubaA:
undetectable		 2hc4A-5ubaA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		4 LEU 8  58
ILE 8 114
ARG 8 117
TYR 8  92
 None
 1.04A 2hc4A-5udb8:
undetectable		 2hc4A-5udb8:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 303
LEU A 300
ILE A 293
ARG A 354
 None
 1.09A 2hc4A-5vo1A:
undetectable		 2hc4A-5vo1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 LEU A2342
LEU A2317
ILE A2432
TRP A2430
 None
 0.96A 2hc4A-6b3rA:
undetectable		 2hc4A-6b3rA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 LEU A  44
ILE A  49
ARG A  50
SER A  51
 None
 1.15A 2hc4A-6c66A:
undetectable		 2hc4A-6c66A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 LEU A 711
LEU A 708
ARG A 702
TYR A 950
 None
 1.23A 2hc4A-6d6yA:
undetectable		 2hc4A-6d6yA:
17.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 6 LEU A 255
ILE A 299
ARG A 302
SER A 303
TRP A 314
TYR A 427
 None
DZW  A 501 (-4.7A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.5A)
DZW  A 501 (-4.9A)
 0.20A 2hc4A-6fobA:
41.3		 2hc4A-6fobA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 5 LEU A 255
LEU A 258
ARG A 302
SER A 303
TRP A 314
 None
DZW  A 501 (-3.8A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.5A)
 0.89A 2hc4A-6fobA:
41.3		 2hc4A-6fobA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Mus musculus) 		no annotation 4 LEU N 249
LEU N 248
ILE N 227
TYR N 298
 None
 1.07A 2hc4A-6g72N:
undetectable		 2hc4A-6g72N:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g8r NUCLEAR BODY PROTEIN
SP140

(Homo sapiens) 		no annotation 4 LEU B 766
ILE B 731
ARG B 734
TYR B 771
 None
 0.97A 2hc4A-6g8rB:
undetectable		 2hc4A-6g8rB:
10.77