SIMILAR PATTERNS OF AMINO ACIDS FOR 2HA6_A_SCKA902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens)
PF00135
(COesterase)
7 GLU A  81
GLU A  84
MET A  85
ASN A  87
ASP A 131
GLU A 452
TYR A 465
None
0.70A 2ha6A-1b41A:
63.1
2ha6A-1b41A:
88.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens)
PF00135
(COesterase)
7 GLU A  81
MET A  85
ASN A  87
ASP A 131
THR A 436
GLU A 452
TYR A 465
None
0.48A 2ha6A-1b41A:
63.1
2ha6A-1b41A:
88.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus)
PF00135
(COesterase)
10 GLU A  81
GLU A  84
MET A  85
ASN A  87
ASP A 131
THR A 436
GLU A 452
LEU A 457
LEU A 463
TYR A 465
None
0.49A 2ha6A-1c2oA:
63.9
2ha6A-1c2oA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus)
PF00135
(COesterase)
6 GLU A  81
GLU A  84
MET A  85
ASN A  87
LEU A 463
TYR A 465
None
1.45A 2ha6A-1c2oA:
63.9
2ha6A-1c2oA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica)
PF00135
(COesterase)
8 GLU A  82
MET A  83
ASN A  85
ASP A 128
GLU A 445
LEU A 450
LEU A 456
TYR A 458
None
0.59A 2ha6A-1gqrA:
60.9
2ha6A-1gqrA:
58.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE


(Thermotoga
maritima)
PF00128
(Alpha-amylase)
PF09178
(DUF1945)
5 ASN A 276
GLU A 315
LEU A  35
LEU A  32
TYR A  31
None
1.35A 2ha6A-1lwhA:
undetectable
2ha6A-1lwhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV)
5 GLU C  39
MET C  62
ASN C  37
LEU C 119
LEU C 116
None
1.49A 2ha6A-1n8yC:
undetectable
2ha6A-1n8yC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf6 BACTERIOFERRITIN

(Desulfovibrio
desulfuricans)
PF00210
(Ferritin)
5 GLU A  99
ASP A  55
THR A 102
GLU A  23
TYR A 106
FE  A 200 (-2.4A)
None
None
None
None
1.43A 2ha6A-1nf6A:
undetectable
2ha6A-1nf6A:
15.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster)
PF00135
(COesterase)
6 GLU A  81
ASN A  84
ASP A 160
GLU A 485
LEU A 496
TYR A 498
None
None
None
None
NAG  A 991 (-4.1A)
None
0.79A 2ha6A-1qonA:
56.8
2ha6A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster)
PF00135
(COesterase)
6 GLU A  81
ASN A  84
THR A 469
GLU A 485
LEU A 496
TYR A 498
None
None
None
None
NAG  A 991 (-4.1A)
None
0.93A 2ha6A-1qonA:
56.8
2ha6A-1qonA:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E


(Bacillus cereus)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
5 ASN A 327
GLU A 369
LEU A  43
LEU A  40
TYR A  39
None
1.26A 2ha6A-1uokA:
undetectable
2ha6A-1uokA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens)
PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg)
5 GLU A 153
ASN A 109
GLU A  12
LEU A  15
LEU A  28
None
1.26A 2ha6A-1uwyA:
3.0
2ha6A-1uwyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus)
PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C)
5 ASN A  19
GLU A 212
LEU A 215
LEU A 266
TYR A 264
None
1.34A 2ha6A-2dbyA:
2.1
2ha6A-2dbyA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqq LEUCINE-RESPONSIVE
REGULATORY PROTEIN


(Escherichia
coli)
PF01037
(AsnC_trans_reg)
PF13412
(HTH_24)
5 ASN A  94
THR A 146
LEU A 130
LEU A 131
TYR A 127
None
1.45A 2ha6A-2gqqA:
undetectable
2ha6A-2gqqA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT


(Aromatoleum
aromaticum)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 GLU A 532
MET A 534
THR A 775
LEU A 506
TYR A 490
None
1.32A 2ha6A-2ivfA:
undetectable
2ha6A-2ivfA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 EXOSOME COMPLEX
EXONUCLEASE RRP43


(Homo sapiens)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
5 GLU C 215
ASN C 147
THR C 204
LEU C 248
LEU C 243
None
1.50A 2ha6A-2nn6C:
undetectable
2ha6A-2nn6C:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
5 ASN A 325
GLU A 368
LEU A  44
LEU A  41
TYR A  40
None
1.41A 2ha6A-2pwhA:
undetectable
2ha6A-2pwhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE


(Escherichia
coli)
PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N)
5 GLU A 445
GLU A 405
LEU A 370
LEU A 374
TYR A 409
None
1.36A 2ha6A-2xdfA:
undetectable
2ha6A-2xdfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA


(Homo sapiens)
PF01504
(PIP5K)
5 GLU A 154
MET A 155
ASN A 157
THR A 196
LEU A 101
None
1.49A 2ha6A-2ybxA:
undetectable
2ha6A-2ybxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK


([Ruminococcus]
gnavus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
5 GLU A 260
ASN A  87
GLU A  76
LEU A 148
TYR A 150
None
1.40A 2ha6A-2yfnA:
undetectable
2ha6A-2yfnA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B
LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Prochlorococcus
marinus)
PF00148
(Oxidored_nitro)
PF08369
(PCP_red)
5 GLU C  57
GLU D 358
LEU D 355
LEU D   5
TYR D 354
None
1.33A 2ha6A-2ynmC:
2.8
2ha6A-2ynmC:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
5 ASN A 324
GLU A 366
LEU A  43
LEU A  40
TYR A  39
None
1.40A 2ha6A-2ze0A:
undetectable
2ha6A-2ze0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 28 KDA FORM
PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM


(Mus musculus)
PF04916
(Phospholip_B)
5 GLU B 350
ASN B 381
GLU A 232
LEU A 235
TYR A 156
None
NA  B 606 ( 4.8A)
None
None
ACT  A   1 ( 4.7A)
1.41A 2ha6A-3fgtB:
undetectable
2ha6A-3fgtB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2


(Mus musculus)
PF04916
(Phospholip_B)
5 GLU A 350
ASN A 381
GLU A 232
LEU A 235
TYR A 156
None
1.40A 2ha6A-3fgwA:
undetectable
2ha6A-3fgwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
5 GLU A 199
ASN A 198
ASP A 232
GLU A 230
LEU A 295
None
1.10A 2ha6A-3iecA:
undetectable
2ha6A-3iecA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE


(Cytophaga
hutchinsonii)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
5 GLU A 408
GLU A 405
GLU A 415
LEU A 422
LEU A 431
None
1.40A 2ha6A-3ilvA:
undetectable
2ha6A-3ilvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF00171
(Aldedh)
5 GLU A 453
ASN A 159
GLU A 241
LEU A 240
LEU A 442
None
1.30A 2ha6A-3rhdA:
undetectable
2ha6A-3rhdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
5 GLU A 562
ASP A 408
LEU A 427
LEU A   9
TYR A  11
None
CA  A 603 (-3.3A)
None
None
None
1.49A 2ha6A-3v4pA:
undetectable
2ha6A-3v4pA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E


(Lactobacillus
acidophilus)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
5 ASN A 314
GLU A 356
LEU A  42
LEU A  39
TYR A  38
None
1.28A 2ha6A-4aieA:
undetectable
2ha6A-4aieA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN


(Pyrococcus sp.
ST04)
no annotation 5 ASN A 488
GLU A 368
LEU A 365
LEU A 503
TYR A 507
None
0.94A 2ha6A-4cmrA:
undetectable
2ha6A-4cmrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efh ACTIN-1

(Acanthamoeba
castellanii)
PF00022
(Actin)
5 GLU A 270
MET A 269
THR A 160
LEU A 185
LEU A 261
None
1.48A 2ha6A-4efhA:
undetectable
2ha6A-4efhA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE


(Pseudomonas
fluorescens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLU A  47
GLU A 358
LEU A 365
LEU A 329
TYR A 350
None
1.23A 2ha6A-4it1A:
undetectable
2ha6A-4it1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE


(Plasmodium
falciparum)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
5 ASN A 458
GLU A 957
LEU A 958
LEU A 476
TYR A 418
None
1.42A 2ha6A-4j3bA:
undetectable
2ha6A-4j3bA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS


(Homo sapiens)
PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
5 GLU A1069
ASN A 469
LEU A1078
LEU A 850
TYR A1056
None
1.30A 2ha6A-4pj3A:
undetectable
2ha6A-4pj3A:
16.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus)
PF00135
(COesterase)
8 GLU A  82
MET A  83
ASN A  85
ASP A 128
GLU A 445
LEU A 450
LEU A 456
TYR A 458
None
None
None
NAG  A 608 ( 4.7A)
None
None
NAG  A 608 ( 4.5A)
None
0.35A 2ha6A-4qwwA:
62.0
2ha6A-4qwwA:
64.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens)
PF01839
(FG-GAP)
5 ASP A 311
THR A 341
GLU A 279
LEU A 309
TYR A 325
None
1.43A 2ha6A-4wk4A:
undetectable
2ha6A-4wk4A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E


(Streptococcus
mutans)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
5 ASN A 311
GLU A 353
LEU A  43
LEU A  40
TYR A  39
None
1.24A 2ha6A-4xb3A:
undetectable
2ha6A-4xb3A:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xii CHOLINESTERASE

(Homo sapiens)
PF00135
(COesterase)
6 GLU A  80
MET A  81
ASN A  83
GLU A 443
LEU A 448
TYR A 456
None
0.69A 2ha6A-4xiiA:
61.8
2ha6A-4xiiA:
52.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7p ALKALINE D-PEPTIDASE

(Bacillus cereus)
PF00144
(Beta-lactamase)
5 GLU A 196
GLU A 193
ASN A 189
LEU A 203
LEU A 205
None
1.39A 2ha6A-4y7pA:
undetectable
2ha6A-4y7pA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anc RIBOSOME MATURATION
PROTEIN SBDS


(Homo sapiens)
PF01172
(SBDS)
PF09377
(SBDS_C)
5 GLU J 219
ASP J 213
THR J 228
LEU J 193
LEU J 190
A  N2522 ( 3.7A)
None
None
None
None
1.44A 2ha6A-5ancJ:
undetectable
2ha6A-5ancJ:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus)
PF07974
(EGF_2)
5 GLU A2091
GLU A2025
ASN A2126
LEU A2055
LEU A2056
None
1.48A 2ha6A-5b4xA:
undetectable
2ha6A-5b4xA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5daj NALD

(Pseudomonas
aeruginosa)
PF00440
(TetR_N)
PF08361
(TetR_C_2)
5 GLU A  60
MET A  61
ASN A  63
THR A  31
LEU A  24
None
1.34A 2ha6A-5dajA:
undetectable
2ha6A-5dajA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jx5 GLUCANASE

(Orpinomyces sp.
Y102)
PF01341
(Glyco_hydro_6)
5 GLU A 246
THR A 325
LEU A 297
LEU A 343
TYR A 339
None
1.34A 2ha6A-5jx5A:
undetectable
2ha6A-5jx5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)


(Helicobacter
pylori)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 ASN A 402
GLU A 192
LEU A 163
LEU A 275
TYR A 153
None
1.50A 2ha6A-5lp4A:
undetectable
2ha6A-5lp4A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes)
PF13416
(SBP_bac_8)
5 GLU A 165
ASN A 182
LEU A 198
LEU A 290
TYR A 202
PGE  A 503 (-3.8A)
None
None
None
None
1.48A 2ha6A-5tu0A:
undetectable
2ha6A-5tu0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X


(Homo sapiens)
no annotation 5 GLU A1915
MET A1916
ASN A1918
LEU A1951
TYR A1953
None
1.39A 2ha6A-5wchA:
undetectable
2ha6A-5wchA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE


(Escherichia
coli)
PF00795
(CN_hydrolase)
5 GLU A 267
GLU A 274
LEU A 281
LEU A 319
TYR A 325
None
1.16A 2ha6A-5xhqA:
undetectable
2ha6A-5xhqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyh CBSA

(Xanthomonas
oryzae)
no annotation 5 GLU A 178
THR A 264
LEU A 232
LEU A 310
TYR A 306
None
1.34A 2ha6A-5xyhA:
undetectable
2ha6A-5xyhA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae)
no annotation 5 MET A 244
ASN A 246
ASP A 289
LEU A 616
TYR A 618
None
0.76A 2ha6A-5ydjA:
59.9
2ha6A-5ydjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae)
no annotation 5 MET A 244
ASN A 246
GLU A 610
LEU A 616
TYR A 618
None
1.20A 2ha6A-5ydjA:
59.9
2ha6A-5ydjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans)
no annotation 5 ASN A 317
GLU A 386
LEU A  46
LEU A  43
TYR A  42
None
1.33A 2ha6A-5ykbA:
undetectable
2ha6A-5ykbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae)
no annotation 5 MET A 244
ASN A 246
ASP A 289
LEU A 616
TYR A 618
None
0.60A 2ha6A-6arxA:
57.2
2ha6A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae)
no annotation 5 MET A 244
ASN A 246
GLU A 610
LEU A 616
TYR A 618
None
1.28A 2ha6A-6arxA:
57.2
2ha6A-6arxA:
9.77