SIMILAR PATTERNS OF AMINO ACIDS FOR 2HA4_A_ACTA544

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 GLY A 107
ALA A 195
TRP A 227
HIS A 435
 None
 0.50A 2ha4A-1aqlA:
46.7		 2ha4A-1aqlA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum) 		PF00314
(Thaumatin) 		5 GLY A  24
GLY A  23
ALA A  16
ALA A  17
PHE A  35
 None
 1.30A 2ha4A-1aunA:
undetectable		 2ha4A-1aunA:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A 120
ALA A 204
TRP A 236
PHE A 295
HIS A 447
 None
 1.08A 2ha4A-1b41A:
62.8		 2ha4A-1b41A:
88.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A 121
GLY A 122
ALA A 204
PHE A 338
HIS A 447
 None
 1.06A 2ha4A-1b41A:
62.8		 2ha4A-1b41A:
88.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		7 GLY A 121
GLY A 122
ALA A 204
TRP A 236
PHE A 295
PHE A 297
HIS A 447
 None
 0.18A 2ha4A-1b41A:
62.8		 2ha4A-1b41A:
88.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 GLY A 120
ALA A 204
TRP A 236
PHE A 295
HIS A 447
 None
 1.13A 2ha4A-1c2oA:
63.2		 2ha4A-1c2oA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 GLY A 121
ALA A 204
TRP A 236
PHE A 295
PHE A 297
 None
 1.41A 2ha4A-1c2oA:
63.2		 2ha4A-1c2oA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		7 GLY A 121
GLY A 122
ALA A 204
TRP A 236
PHE A 295
PHE A 297
HIS A 447
 None
 0.24A 2ha4A-1c2oA:
63.2		 2ha4A-1c2oA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
ALA A 210
PHE A 345
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-4.0A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.8A)
 0.98A 2ha4A-1cleA:
40.4		 2ha4A-1cleA:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
PHE A 345
PHE A 296
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-3.7A)
CLL  A 801 (-4.8A)
 1.35A 2ha4A-1cleA:
40.4		 2ha4A-1cleA:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		6 GLY A 123
GLY A 124
ALA A 210
PHE A 345
PHE A 296
HIS A 449
 None
 1.45A 2ha4A-1crlA:
39.8		 2ha4A-1crlA:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
ALA A 210
PHE A 415
HIS A 449
 None
 1.48A 2ha4A-1crlA:
39.8		 2ha4A-1crlA:
32.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7b CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF16010
(CDH-cyt) 		4 GLY A  62
GLY A  63
ALA A  60
PHE A 169
 None
None
HEM  A 401 ( 4.2A)
None
 0.49A 2ha4A-1d7bA:
undetectable		 2ha4A-1d7bA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e25 EXTENDED-SPECTRUM
BETA-LACTAMASE PER-1

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 GLY A 144
GLY A 143
ALA A 146
ALA A 147
 None
 0.60A 2ha4A-1e25A:
undetectable		 2ha4A-1e25A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE

(Agrobacterium
sp. KNK712) 		PF00795
(CN_hydrolase) 		5 GLY A 194
GLY A 193
ALA A 233
PHE A 169
HIS A 215
 None
 1.35A 2ha4A-1erzA:
undetectable		 2ha4A-1erzA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 GLY A  83
GLY A  84
ALA A 156
PHE A 214
HIS A 282
 EPE  A 455 (-3.3A)
EPE  A 455 (-3.3A)
EPE  A 455 (-3.8A)
EPE  A 455 (-4.8A)
EPE  A 455 (-4.0A)
 0.89A 2ha4A-1evqA:
17.9		 2ha4A-1evqA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		6 GLY A 118
GLY A 119
ALA A 201
PHE A 331
PHE A 290
HIS A 440
 SAF  A1998 ( 3.5A)
EMM  A1999 (-3.5A)
EMM  A1999 (-3.6A)
EMM  A1999 (-4.7A)
EMM  A1999 (-4.1A)
EMM  A1999 ( 3.8A)
 1.12A 2ha4A-1gqrA:
60.4		 2ha4A-1gqrA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		7 GLY A 118
GLY A 119
ALA A 201
TRP A 233
PHE A 288
PHE A 290
HIS A 440
 SAF  A1998 ( 3.5A)
EMM  A1999 (-3.5A)
EMM  A1999 (-3.6A)
EMM  A1999 (-4.0A)
EMM  A1999 (-4.3A)
EMM  A1999 (-4.1A)
EMM  A1999 ( 3.8A)
 0.67A 2ha4A-1gqrA:
60.4		 2ha4A-1gqrA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
ALA A 210
PHE A 345
HIS A 449
 None
 0.94A 2ha4A-1gz7A:
41.1		 2ha4A-1gz7A:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 GLY A  88
GLY A  89
ALA A 161
PHE A 218
HIS A 285
 EPE  A 455 (-3.7A)
EPE  A 455 (-3.4A)
EPE  A 455 (-3.4A)
EPE  A 455 ( 4.9A)
EPE  A 455 (-4.6A)
 1.02A 2ha4A-1jjiA:
18.5		 2ha4A-1jjiA:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A 107
ALA A 195
TRP A 227
HIS A 435
 None
 0.27A 2ha4A-1jmyA:
46.3		 2ha4A-1jmyA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		4 GLY A 142
GLY A 143
ALA A 222
HIS A 467
 None
 0.41A 2ha4A-1k4yA:
48.5		 2ha4A-1k4yA:
33.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		4 GLY A  88
GLY A  89
ALA A 161
HIS A 290
 CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.2A)
CAC  A 500 (-4.1A)
 0.35A 2ha4A-1lzkA:
18.8		 2ha4A-1lzkA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		5 GLY A 538
ALA A 542
ALA A 352
TRP A 329
PHE A 348
 None
 1.45A 2ha4A-1q50A:
2.1		 2ha4A-1q50A:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 GLY A 149
GLY A 150
ALA A 239
PHE A 371
HIS A 480
 SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.09A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 GLY A 150
ALA A 239
TRP A 271
PHE A 440
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.2A)
SO4  A 593 (-4.4A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 1.46A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 GLY A 150
GLY A 151
ALA A 239
PHE A 371
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-3.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.15A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		6 GLY A 150
GLY A 151
ALA A 239
TRP A 271
PHE A 330
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-3.2A)
SO4  A 593 (-4.4A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.1A)
 0.43A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t11 TRIGGER FACTOR

(Vibrio cholerae) 		PF00254
(FKBP_C)
PF05697
(Trigger_N)
PF05698
(Trigger_C) 		5 GLY A 180
GLY A 170
ALA A 182
PHE A 198
PHE A 233
 None
 1.33A 2ha4A-1t11A:
undetectable		 2ha4A-1t11A:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 GLY A 126
GLY A 127
ALA A 211
PHE A 342
HIS A 440
 EDO  A1902 ( 4.3A)
EDO  A1902 (-3.6A)
EDO  A1902 (-4.0A)
EDO  A1902 (-4.3A)
EDO  A1902 ( 4.9A)
 1.17A 2ha4A-1ukcA:
38.1		 2ha4A-1ukcA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 GLY A 127
GLY A 128
ALA A 211
PHE A 342
HIS A 440
 EDO  A1902 (-3.6A)
EDO  A1902 (-3.4A)
EDO  A1902 (-4.0A)
EDO  A1902 (-4.3A)
EDO  A1902 ( 4.9A)
 1.34A 2ha4A-1ukcA:
38.1		 2ha4A-1ukcA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 GLY A 127
GLY A 128
ALA A 211
PHE A 400
HIS A 440
 EDO  A1902 (-3.6A)
EDO  A1902 (-3.4A)
EDO  A1902 (-4.0A)
None
EDO  A1902 ( 4.9A)
 1.32A 2ha4A-1ukcA:
38.1		 2ha4A-1ukcA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvy MYOGLOBIN

(Paramecium
caudatum) 		PF01152
(Bac_globin) 		4 GLY A   8
GLY A   7
ALA A  10
ALA A  11
 None
 0.62A 2ha4A-1uvyA:
undetectable		 2ha4A-1uvyA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a87 THIOREDOXIN
REDUCTASE

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 GLY A 162
GLY A 163
ALA A 167
PHE A 208
PHE A 190
 NAP  A 381 ( 3.9A)
NAP  A 381 ( 4.7A)
None
None
None
 1.14A 2ha4A-2a87A:
undetectable		 2ha4A-2a87A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		5 GLY A  82
GLY A  83
ALA A 155
PHE A 214
HIS A 281
 None
 0.90A 2ha4A-2c7bA:
18.8		 2ha4A-2c7bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		4 GLY A 144
GLY A 143
ALA A 146
ALA A 147
 None
 0.58A 2ha4A-2cc1A:
undetectable		 2ha4A-2cc1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		5 GLY A 231
GLY A 230
ALA A 261
ALA A 233
HIS A 259
 None
None
None
None
CU  A 501 (-3.2A)
 1.29A 2ha4A-2dv6A:
undetectable		 2ha4A-2dv6A:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 GLY A 146
GLY A 147
ALA A 227
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
 0.30A 2ha4A-2fj0A:
46.5		 2ha4A-2fj0A:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A  34
GLY A  36
ALA A  38
ALA A  37
PHE A 453
 None
 1.16A 2ha4A-2fjaA:
undetectable		 2ha4A-2fjaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A  34
GLY A  36
ALA A 161
ALA A  38
PHE A 453
 None
 1.46A 2ha4A-2fjaA:
undetectable		 2ha4A-2fjaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kl3 ALR3790 PROTEIN

(Nostoc sp. PCC
7120) 		PF00581
(Rhodanese) 		4 GLY A  93
GLY A  92
ALA A  95
ALA A  96
 None
 0.61A 2ha4A-2kl3A:
2.0		 2ha4A-2kl3A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 232
GLY A 231
ALA A 235
ALA A 236
HIS A 279
 None
 1.40A 2ha4A-2nlxA:
undetectable		 2ha4A-2nlxA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 232
GLY A 231
ALA A 235
ALA A 236
HIS A 286
 None
 1.17A 2ha4A-2nlxA:
undetectable		 2ha4A-2nlxA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 GLY C 168
ALA C 160
ALA C 167
PHE C 210
HIS C 207
 None
 1.07A 2ha4A-2nn3C:
3.6		 2ha4A-2nn3C:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 GLY A  92
GLY A  93
ALA A 170
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-3.2A)
4PA  A 369 (-4.8A)
 0.27A 2ha4A-2o7rA:
19.0		 2ha4A-2o7rA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0l THIOREDOXIN
REDUCTASE

(Helicobacter
pylori) 		PF07992
(Pyr_redox_2) 		5 GLY A 150
GLY A 151
ALA A 155
PHE A 196
PHE A 178
 NAP  A 401 ( 4.0A)
NAP  A 401 (-3.1A)
None
None
None
 1.12A 2ha4A-2q0lA:
undetectable		 2ha4A-2q0lA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		4 GLY A  34
GLY A  35
ALA A 103
HIS A 247
 PO4  A 273 (-3.3A)
PO4  A 273 (-3.5A)
PO4  A 273 (-3.5A)
PO4  A 273 (-4.0A)
 0.28A 2ha4A-2qruA:
14.3		 2ha4A-2qruA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		5 GLY A  85
GLY A  86
ALA A 158
PHE A 217
HIS A 284
 None
 0.96A 2ha4A-2yh2A:
18.8		 2ha4A-2yh2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		5 GLY A  79
GLY A  80
ALA A 151
PHE A 206
HIS A 273
 DEP  A 304 (-3.6A)
DEP  A 304 (-3.5A)
DEP  A 304 (-3.5A)
DEP  A 304 (-4.5A)
DEP  A 304 (-4.1A)
 0.98A 2ha4A-3ailA:
18.4		 2ha4A-3ailA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		5 GLY A 432
GLY A 433
ALA A 511
ALA A 512
HIS A 625
 None
 0.76A 2ha4A-3azqA:
7.3		 2ha4A-3azqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		4 GLY A 433
ALA A 511
ALA A 512
HIS A 625
 None
 0.48A 2ha4A-3azqA:
7.3		 2ha4A-3azqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLY A 263
GLY A 262
ALA A 265
ALA A 266
 None
 0.61A 2ha4A-3e77A:
undetectable		 2ha4A-3e77A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		5 GLY A 161
GLY A 162
ALA A 166
PHE A 207
PHE A 189
 NAP  A4001 ( 4.1A)
NAP  A4001 ( 4.6A)
None
None
None
 1.24A 2ha4A-3f8rA:
undetectable		 2ha4A-3f8rA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		4 GLY A  93
GLY A  94
ALA A 166
HIS A 292
 SEP  A 165 ( 3.6A)
SEP  A 165 ( 3.5A)
SEP  A 165 ( 3.2A)
SEP  A 165 ( 3.9A)
 0.24A 2ha4A-3ga7A:
17.9		 2ha4A-3ga7A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		4 GLY A  52
GLY A  53
ALA A 128
HIS A 231
 None
 0.47A 2ha4A-3hxkA:
16.3		 2ha4A-3hxkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A  89
GLY A  90
ALA A 158
HIS A 281
 None
 0.26A 2ha4A-3k6kA:
3.2		 2ha4A-3k6kA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A1142
GLY A1143
ALA A1222
HIS A1468
 WW2  A 193 (-3.4A)
WW2  A 193 (-3.4A)
WW2  A 193 (-2.9A)
None
 0.29A 2ha4A-3k9bA:
46.7		 2ha4A-3k9bA:
35.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum) 		PF07859
(Abhydrolase_3) 		5 GLY A  90
GLY A  91
ALA A 163
PHE A 256
HIS A 284
 None
 1.35A 2ha4A-3qh4A:
18.0		 2ha4A-3qh4A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		4 GLY A 261
GLY A 260
ALA A 263
ALA A 264
 None
 0.59A 2ha4A-3qm2A:
undetectable		 2ha4A-3qm2A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		5 GLY A  38
GLY A  39
ALA A 219
ALA A 220
PHE A 297
 FMT  A 370 (-3.7A)
FMT  A 370 (-3.8A)
GOL  A 364 (-3.4A)
FMT  A 370 (-3.3A)
GOL  A 364 (-4.9A)
 1.00A 2ha4A-3rpwA:
undetectable		 2ha4A-3rpwA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 GLY X  46
ALA X 123
ALA X 103
TRP X 149
PHE X  57
 None
 1.47A 2ha4A-3rwkX:
undetectable		 2ha4A-3rwkX:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		5 GLY A  19
GLY A  21
ALA A  23
ALA A  22
PHE A 462
 None
 1.20A 2ha4A-3ukfA:
undetectable		 2ha4A-3ukfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A  76
GLY A  77
ALA A 145
HIS A 268
 None
 0.30A 2ha4A-3v9aA:
6.8		 2ha4A-3v9aA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbj GALACTOSIDE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 GLY A  71
GLY A  70
ALA A  92
ALA A  91
 None
 0.62A 2ha4A-3vbjA:
undetectable		 2ha4A-3vbjA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		4 GLY A 144
GLY A 143
ALA A 146
ALA A 147
 None
 0.63A 2ha4A-3w4qA:
undetectable		 2ha4A-3w4qA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		5 GLY A  84
GLY A  85
ALA A 157
PHE A  89
HIS A 281
 None
 1.08A 2ha4A-3wj2A:
7.9		 2ha4A-3wj2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		4 GLY A  85
GLY A  86
ALA A 157
HIS A 281
 None
 0.30A 2ha4A-3wj2A:
7.9		 2ha4A-3wj2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 GLY A 131
GLY A 132
TRP A 275
PHE A 241
PHE A 271
 None
 1.16A 2ha4A-3zukA:
undetectable		 2ha4A-3zukA:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 134
GLY A 135
ALA A 221
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-3.5A)
None
None
 1.02A 2ha4A-4be9A:
40.3		 2ha4A-4be9A:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 GLY A  18
GLY A  20
ALA A  22
ALA A  21
PHE A 438
 None
 1.19A 2ha4A-4dshA:
undetectable		 2ha4A-4dshA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 5 GLY D 482
ALA D 486
ALA D 295
TRP D 272
PHE D 291
 None
 1.47A 2ha4A-4em6D:
undetectable		 2ha4A-4em6D:
24.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		6 GLY A 136
GLY A 137
ALA A 219
TRP A 251
PHE A 309
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-3.3A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
 0.78A 2ha4A-4fnmA:
38.3		 2ha4A-4fnmA:
30.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		4 GLY A  84
GLY A  85
ALA A 111
HIS A 296
 LMS  A 401 (-3.3A)
LMS  A 401 ( 4.7A)
LMS  A 401 (-3.4A)
LMS  A 401 (-4.3A)
 0.59A 2ha4A-4injA:
3.6		 2ha4A-4injA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 GLY A 295
GLY A 294
TRP A 291
PHE A 199
HIS A 220
 None
 1.29A 2ha4A-4iviA:
undetectable		 2ha4A-4iviA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 4 GLY A  76
GLY A  77
ALA A 164
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-3.7A)
EGR  A 501 (-3.8A)
 0.51A 2ha4A-4j0kA:
19.1		 2ha4A-4j0kA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli) 		PF07859
(Abhydrolase_3) 		4 GLY A  93
GLY A  94
ALA A 166
HIS A 292
 SEB  A 165 ( 3.6A)
SEB  A 165 ( 3.5A)
SEB  A 165 ( 3.4A)
SEB  A 165 ( 4.1A)
 0.21A 2ha4A-4kryA:
4.5		 2ha4A-4kryA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		5 GLY X  75
GLY X  76
ALA X 147
PHE X 245
HIS X 278
 2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-3.4A)
2HD  X 401 (-4.6A)
2HD  X 401 (-3.5A)
 1.23A 2ha4A-4n5iX:
20.6		 2ha4A-4n5iX:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN

(Pseudomonas sp.
ECU1011) 		PF07859
(Abhydrolase_3) 		5 GLY A  87
GLY A  88
ALA A 159
PHE A 216
HIS A 286
 None
 0.92A 2ha4A-4ou4A:
5.5		 2ha4A-4ou4A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		5 GLY A  80
GLY A  81
ALA A 152
PHE A 206
HIS A 274
 None
 0.98A 2ha4A-4p9nA:
18.1		 2ha4A-4p9nA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 GLY A 104
GLY A 103
ALA A 106
ALA A 107
 None
 0.59A 2ha4A-4q38A:
undetectable		 2ha4A-4q38A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified) 		PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3) 		4 GLY A  42
GLY A  43
ALA A 114
HIS A 201
 F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-3.6A)
None
 0.31A 2ha4A-4q3kA:
17.3		 2ha4A-4q3kA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5g SERUM AMYLOID A-3
PROTEIN

(Mus musculus) 		PF00277
(SAA) 		5 GLY A  69
GLY A  68
ALA A  72
ALA A  28
PHE A  24
 None
 1.28A 2ha4A-4q5gA:
undetectable		 2ha4A-4q5gA:
13.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 GLY A 117
ALA A 201
TRP A 233
PHE A 288
HIS A 440
 None
 1.07A 2ha4A-4qwwA:
61.9		 2ha4A-4qwwA:
64.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 GLY A 117
GLY A 118
ALA A 201
PHE A 331
HIS A 440
 None
 1.10A 2ha4A-4qwwA:
61.9		 2ha4A-4qwwA:
64.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 GLY A 118
GLY A 119
ALA A 201
PHE A 331
HIS A 440
 None
 1.11A 2ha4A-4qwwA:
61.9		 2ha4A-4qwwA:
64.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		7 GLY A 118
GLY A 119
ALA A 201
TRP A 233
PHE A 288
PHE A 290
HIS A 440
 None
 0.25A 2ha4A-4qwwA:
61.9		 2ha4A-4qwwA:
64.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
GLY A  90
ALA A 162
PHE A 221
HIS A 292
 None
 0.95A 2ha4A-4wy5A:
19.2		 2ha4A-4wy5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		5 GLY A  90
GLY A  91
ALA A 165
PHE A 221
HIS A 291
 None
 0.92A 2ha4A-4wy8A:
19.1		 2ha4A-4wy8A:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A 115
GLY A 116
ALA A 199
TRP A 231
HIS A 438
 None
40V  A1001 (-3.2A)
None
40V  A1001 (-3.4A)
40V  A1001 (-3.6A)
 1.26A 2ha4A-4xiiA:
61.7		 2ha4A-4xiiA:
52.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A 116
GLY A 117
ALA A 199
TRP A 231
HIS A 438
 40V  A1001 (-3.2A)
40V  A1001 (-3.4A)
None
40V  A1001 (-3.4A)
40V  A1001 (-3.6A)
 0.45A 2ha4A-4xiiA:
61.7		 2ha4A-4xiiA:
52.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		5 GLY A  87
GLY A  88
ALA A 160
PHE A 216
HIS A 283
 None
 0.95A 2ha4A-4ypvA:
5.7		 2ha4A-4ypvA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A  75
GLY A  76
ALA A 152
HIS A 263
 SEB  A 151 ( 3.8A)
SEB  A 151 ( 3.5A)
SEB  A 151 ( 3.4A)
SEB  A 151 ( 4.1A)
 0.17A 2ha4A-4zrsA:
21.3		 2ha4A-4zrsA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoc ESTERASE

(Thermogutta
terrifontis) 		PF07859
(Abhydrolase_3) 		4 GLY A  53
GLY A  54
ALA A 127
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.19A 2ha4A-5aocA:
5.0		 2ha4A-5aocA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 GLY A 253
GLY A 252
ALA A 255
ALA A 256
 None
 0.60A 2ha4A-5cerA:
undetectable		 2ha4A-5cerA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		4 GLY A 121
GLY A 120
ALA A 123
ALA A 124
 None
 0.62A 2ha4A-5e2eA:
undetectable		 2ha4A-5e2eA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 GLY A 139
GLY A 138
ALA A 141
ALA A 142
 None
 0.63A 2ha4A-5f83A:
undetectable		 2ha4A-5f83A:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLY A 125
GLY A 126
ALA A 205
PHE A 286
HIS A 449
 None
 1.19A 2ha4A-5fv4A:
50.1		 2ha4A-5fv4A:
35.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLY A 125
GLY A 126
ALA A 205
PHE A 300
HIS A 449
 None
 0.65A 2ha4A-5fv4A:
50.1		 2ha4A-5fv4A:
35.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A  77
GLY A  78
ALA A 146
HIS A 269
 None
 0.25A 2ha4A-5gmsA:
5.9		 2ha4A-5gmsA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h35 MEMBRANE PROTEIN
TRIC

(Sulfolobus
solfataricus) 		PF03458
(UPF0126) 		5 GLY C 132
GLY C 133
ALA C  44
PHE C 104
PHE C  16
 PX4  C 303 ( 4.6A)
None
None
None
None
 1.31A 2ha4A-5h35C:
undetectable		 2ha4A-5h35C:
18.49