SIMILAR PATTERNS OF AMINO ACIDS FOR 2H79_A_T3A1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsl BACTERIAL LUCIFERASE

(Vibrio harveyi) 		PF00296
(Bac_luciferase) 		5 ARG A  15
ALA A 243
LEU A 247
ILE A 273
PHE A   6
 None
 1.04A 2h79A-1bslA:
0.0		 2h79A-1bslA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.80A 2h79A-1ej6B:
1.0		 2h79A-1ej6B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 ILE A  44
ILE A  45
ALA A  35
ALA A 155
ILE A 189
 None
 0.97A 2h79A-1f82A:
0.0		 2h79A-1f82A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 ILE A 197
ILE A 200
ALA A 183
ALA A  39
ILE A  35
 None
 0.95A 2h79A-1kplA:
0.4		 2h79A-1kplA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mns MANDELATE RACEMASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  25
LEU A 200
SER A 199
LEU A 212
ILE A 220
 None
 1.05A 2h79A-1mnsA:
0.0		 2h79A-1mnsA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 221
ILE A 222
ALA A 225
MET A 256
ALA A 263
LEU A 276
SER A 277
LEU A 292
ILE A 299
HIS A 381
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-3.6A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-4.4A)
 0.42A 2h79A-1navA:
37.5		 2h79A-1navA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 222
ALA A 225
ARG A 228
MET A 256
ALA A 263
LEU A 276
SER A 277
LEU A 292
ILE A 299
HIS A 381
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-4.4A)
 0.68A 2h79A-1navA:
37.5		 2h79A-1navA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ort ORNITHINE
TRANSCARBAMOYLASE

(Pseudomonas
aeruginosa) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ILE A 324
ILE A 327
ALA A 326
ILE A 175
HIS A  15
 None
 0.98A 2h79A-1ortA:
0.0		 2h79A-1ortA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 275
ILE A 276
ALA A 279
ARG A 282
MET A 310
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.56A 2h79A-1q4xA:
36.5		 2h79A-1q4xA:
81.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 276
ALA A 279
ARG A 282
ALA A 317
LEU A 341
ILE A 353
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.1A)
None
None
 1.42A 2h79A-1q4xA:
36.5		 2h79A-1q4xA:
81.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6w MONOAMINE OXIDASE
REGULATORY PROTEIN,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF01575
(MaoC_dehydratas) 		5 ILE A 113
ALA A 115
ALA A 149
LEU A 147
ILE A  98
 None
 1.08A 2h79A-1q6wA:
0.0		 2h79A-1q6wA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 ILE A 146
ILE A 148
ALA A 216
ALA A 156
LEU A 184
 None
 0.99A 2h79A-1rj6A:
undetectable		 2h79A-1rj6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 ILE A 146
ILE A 148
ALA A 216
LEU A 184
LEU A 161
 None
 1.08A 2h79A-1rj6A:
undetectable		 2h79A-1rj6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		5 ILE A   8
ILE A  51
ALA A 223
LEU A 224
SER A 225
 None
 1.09A 2h79A-1sgvA:
undetectable		 2h79A-1sgvA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		5 ILE A  85
ALA A 210
ALA A  99
LEU A 203
ILE A 103
 None
None
PLP  A 600 (-3.9A)
None
None
 1.04A 2h79A-1t3iA:
undetectable		 2h79A-1t3iA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		5 ILE A 155
ALA A 150
ALA A 145
LEU A 146
ILE A  42
 None
 1.09A 2h79A-1tzbA:
undetectable		 2h79A-1tzbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 ILE A 440
ILE A 443
ALA A 384
LEU A 423
ILE A 479
 None
 0.93A 2h79A-1upxA:
undetectable		 2h79A-1upxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 ILE A 270
ALA A 263
ALA A 326
LEU A 306
ILE A 323
 None
 1.01A 2h79A-1vqzA:
undetectable		 2h79A-1vqzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		5 ILE A 415
ILE A 414
ALA A 359
LEU A 366
ILE A 355
 None
 1.04A 2h79A-1yp4A:
undetectable		 2h79A-1yp4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		5 ILE A 191
ALA A 209
LEU A 172
ILE A 346
PHE A 262
 None
 1.09A 2h79A-2a9fA:
undetectable		 2h79A-2a9fA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		5 ILE A  81
ALA A  82
ILE A 199
HIS A 201
PHE A  48
 None
 1.10A 2h79A-2d57A:
undetectable		 2h79A-2d57A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		5 ILE A 246
ALA A 245
ALA A 238
LEU A 265
PHE A 329
 None
None
XTS  A 502 ( 4.3A)
None
None
 1.08A 2h79A-2eg5A:
undetectable		 2h79A-2eg5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		5 ILE A  59
ALA A  96
ALA A  66
LEU A  23
ILE A  27
 None
 1.04A 2h79A-2ehhA:
undetectable		 2h79A-2ehhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbz OLIGORIBONUCLEASE

(Xanthomonas
campestris) 		PF00929
(RNase_T) 		5 ILE A  29
ILE A  51
ARG A  77
LEU A 119
ILE A  14
 None
 0.91A 2h79A-2gbzA:
undetectable		 2h79A-2gbzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 115
LEU A  91
SER A  92
LEU A  78
ILE A  45
 None
 1.04A 2h79A-2i6uA:
undetectable		 2h79A-2i6uA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A  42
ILE A   3
ALA A  72
LEU A  85
ILE A  74
 None
 0.99A 2h79A-2j6iA:
undetectable		 2h79A-2j6iA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 ILE A 173
ARG A 202
ALA A 165
LEU A 169
ILE A 341
 None
None
CL  A1369 (-4.0A)
None
None
 0.99A 2h79A-2ji4A:
undetectable		 2h79A-2ji4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrb ORF 1 PROTEIN

(Mus musculus) 		PF17490
(Tnp_22_dsRBD) 		5 ILE A 352
ALA A 348
LEU A 343
LEU A 307
ILE A 324
 None
 1.01A 2h79A-2jrbA:
undetectable		 2h79A-2jrbA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2klh C-MYC-RESPONSIVE
PROTEIN RCL

(Rattus
norvegicus) 		PF05014
(Nuc_deoxyrib_tr) 		5 ILE A 120
ALA A 123
ALA A  97
LEU A  94
HIS A 156
 None
 1.08A 2h79A-2klhA:
undetectable		 2h79A-2klhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l1n UNCHARACTERIZED
PROTEIN

(Synechococcus
elongatus) 		PF08853
(DUF1823) 		5 ILE A   5
ILE A   3
ALA A  30
ALA A  25
LEU A  26
 None
 1.09A 2h79A-2l1nA:
undetectable		 2h79A-2l1nA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00497
(SBP_bac_3) 		6 ALA A 209
MET A  37
ALA A  66
LEU A 199
LEU A  87
ILE A  68
 None
 1.37A 2h79A-2laoA:
undetectable		 2h79A-2laoA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 ILE A  44
ILE A  45
ALA A  35
ALA A 155
ILE A 189
 None
 0.89A 2h79A-2np0A:
undetectable		 2h79A-2np0A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ILE A 643
ALA A 645
ALA A 610
LEU A 607
ILE A 545
 None
 1.10A 2h79A-2nq5A:
undetectable		 2h79A-2nq5A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 ILE A 283
ALA A 281
ALA A 275
LEU A 279
ILE A 203
 None
 1.09A 2h79A-2qcvA:
undetectable		 2h79A-2qcvA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ILE A   7
ILE A   8
ALA A  33
LEU A  86
HIS A  55
 None
 0.96A 2h79A-2qk4A:
undetectable		 2h79A-2qk4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 ILE A 197
ILE A 200
ALA A 183
ALA A  39
ILE A  35
 None
 0.99A 2h79A-2r9hA:
undetectable		 2h79A-2r9hA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ILE A  96
ILE A  54
ALA A  68
LEU A  85
LEU A  42
 None
 0.99A 2h79A-2vwkA:
undetectable		 2h79A-2vwkA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1

(Homo sapiens) 		PF02144
(Rad1) 		6 ILE C  84
ALA C  40
ALA C  63
LEU C  31
ILE C  65
PHE C  82
 None
 1.45A 2h79A-3a1jC:
undetectable		 2h79A-3a1jC:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 ILE A 888
ALA A 886
ALA A 880
LEU A 884
HIS A 730
 None
 0.99A 2h79A-3c10A:
undetectable		 2h79A-3c10A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi1 NA(+)/H(+)
ANTIPORTER NHAA

(Escherichia
coli) 		PF06965
(Na_H_antiport_1) 		5 ILE A 169
ILE A 168
ALA A 167
MET A 341
ILE A 134
 None
 1.06A 2h79A-3fi1A:
undetectable		 2h79A-3fi1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  90
ALA A  51
LEU A 112
LEU A  34
ILE A  73
 None
 1.07A 2h79A-3hveA:
undetectable		 2h79A-3hveA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG

(Homo sapiens) 		PF03932
(CutC) 		5 ILE A 189
ALA A 178
LEU A 182
LEU A 213
ILE A 204
 None
 1.07A 2h79A-3iwpA:
undetectable		 2h79A-3iwpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 5 ILE B 979
ILE B 820
ALA B 982
LEU B 967
PHE B 819
 None
 0.97A 2h79A-3iz3B:
undetectable		 2h79A-3iz3B:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		5 ILE A 307
LEU A 303
LEU A 281
ILE A 294
HIS A 226
 None
 1.05A 2h79A-3n11A:
undetectable		 2h79A-3n11A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2r RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 ILE B 118
ILE B 122
ALA B 121
LEU B  21
PHE B 130
 None
 1.08A 2h79A-3o2rB:
undetectable		 2h79A-3o2rB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 ILE A 260
ILE A 259
ALA A 225
ALA A 216
LEU A 296
 None
 1.01A 2h79A-3o8lA:
undetectable		 2h79A-3o8lA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 ILE A  13
ALA A 120
LEU A  23
ILE A 123
PHE A 102
 None
None
GOL  A 318 ( 4.5A)
None
None
 1.08A 2h79A-3op1A:
undetectable		 2h79A-3op1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		5 ILE A 247
ALA A 231
LEU A 235
LEU A 266
ILE A 185
 None
 1.10A 2h79A-3pt1A:
undetectable		 2h79A-3pt1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u24 PUTATIVE LIPOPROTEIN

(Shewanella
oneidensis) 		PF05960
(DUF885) 		5 ILE A 229
ALA A 233
LEU A  73
ILE A  75
PHE A 202
 None
None
EDO  A 600 (-4.8A)
CA  A 607 ( 4.8A)
None
 0.98A 2h79A-3u24A:
undetectable		 2h79A-3u24A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		5 ILE A 104
LEU A  38
SER A  42
LEU A  16
ILE A  13
 None
 1.03A 2h79A-3v4yA:
undetectable		 2h79A-3v4yA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlp THIOREDOXIN
PEROXIDASE

(Schistosoma
mansoni) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 ILE A  18
ALA A  16
ALA A  71
LEU A  93
ILE A  52
 None
 1.02A 2h79A-3zlpA:
undetectable		 2h79A-3zlpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 ILE A  45
ILE A  46
ALA A  36
ALA A 156
ILE A 190
 None
 0.90A 2h79A-3zuqA:
undetectable		 2h79A-3zuqA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3s 6-PHOSPHOFRUCTOKINAS
E

(Bacillus
subtilis) 		PF00365
(PFK) 		5 ILE A 218
ILE A 217
ALA A 186
ALA A 177
LEU A 247
 None
 0.94A 2h79A-4a3sA:
undetectable		 2h79A-4a3sA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A 402
ILE A 439
ALA A 446
LEU A 347
ILE A 345
 None
 1.04A 2h79A-4c13A:
undetectable		 2h79A-4c13A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A 870
ALA A 869
ALA A1047
LEU A 829
ILE A1051
 None
 1.07A 2h79A-4f4cA:
undetectable		 2h79A-4f4cA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1

(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		no annotation 5 ILE B 200
ALA B 290
LEU B 287
LEU B 238
ILE B 240
 None
 1.07A 2h79A-4h2xB:
undetectable		 2h79A-4h2xB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		5 ILE A 106
ALA A 125
ALA A  96
LEU A  93
LEU A  75
 None
 1.10A 2h79A-4il5A:
undetectable		 2h79A-4il5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4b PYLD

(Methanosarcina
barkeri) 		no annotation 6 ALA A 119
ALA A 252
LEU A 255
SER A 257
LEU A  67
ILE A  70
 None
 1.38A 2h79A-4j4bA:
undetectable		 2h79A-4j4bA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpd PROTEIN CYAY

(Burkholderia
cenocepacia) 		PF01491
(Frataxin_Cyay) 		5 ILE A  51
ILE A  63
ALA A  65
LEU A  42
ILE A 104
 None
 1.03A 2h79A-4jpdA:
undetectable		 2h79A-4jpdA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 ILE A 450
ALA A 457
ALA A 265
LEU A 311
ILE A 358
 None
 1.06A 2h79A-4oflA:
undetectable		 2h79A-4oflA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase) 		5 ILE A 180
ALA A 210
LEU A 265
ILE A 263
HIS A 190
 None
 1.03A 2h79A-4qmgA:
undetectable		 2h79A-4qmgA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		5 ILE A 432
ALA A 365
ALA A 358
LEU A  46
ILE A 137
 None
 1.08A 2h79A-4rasA:
undetectable		 2h79A-4rasA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq2 PUTATIVE
PHYCOERYTHRIN LYASE

(Guillardia
theta) 		PF09367
(CpeS) 		5 ILE A 151
ILE A 152
ALA A  24
LEU A 161
HIS A 156
 None
 0.92A 2h79A-4tq2A:
undetectable		 2h79A-4tq2A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 ILE A 269
ILE A 268
ALA A 234
ALA A 225
LEU A 305
 None
 1.02A 2h79A-4u1rA:
undetectable		 2h79A-4u1rA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1

(Mus musculus) 		no annotation 5 ILE A1644
ALA A1406
LEU A1403
LEU A1613
ILE A1410
 None
 1.07A 2h79A-4w8pA:
undetectable		 2h79A-4w8pA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Sinorhizobium
meliloti) 		PF00496
(SBP_bac_5) 		5 ILE A 225
ILE A  42
ALA A 249
MET A 516
LEU A 220
 None
 0.88A 2h79A-4wedA:
undetectable		 2h79A-4wedA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE

(Haemophilus
influenzae) 		PF00106
(adh_short) 		5 ILE A  95
ILE A  97
ALA A  36
LEU A  44
ILE A  59
 None
 1.04A 2h79A-4wuvA:
undetectable		 2h79A-4wuvA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 ILE C 187
ILE C 207
ALA C 185
ARG C 160
ILE C 296
 None
 1.08A 2h79A-4yfaC:
undetectable		 2h79A-4yfaC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 5 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
 None
 1.05A 2h79A-5a0kA:
undetectable		 2h79A-5a0kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 ILE A 164
ILE A 168
ALA A 167
ALA A 240
ILE A 244
 None
 0.91A 2h79A-5a3yA:
undetectable		 2h79A-5a3yA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 ILE A 389
ILE A 409
ALA A 387
ARG A 362
ILE A 498
 None
 1.04A 2h79A-5c9iA:
undetectable		 2h79A-5c9iA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy4 OLIGORIBONUCLEASE

(Acinetobacter
baumannii) 		PF00929
(RNase_T) 		5 ILE A  27
ILE A  49
ARG A  75
LEU A 117
ILE A  12
 None
 0.94A 2h79A-5cy4A:
undetectable		 2h79A-5cy4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u CONTACTIN-6

(Mus musculus) 		PF13927
(Ig_3) 		5 ILE B 237
ALA B 239
SER B 243
LEU B 282
ILE B 273
 None
 0.97A 2h79A-5e5uB:
undetectable		 2h79A-5e5uB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		5 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.96A 2h79A-5egeA:
undetectable		 2h79A-5egeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 ILE A 164
ILE A 168
ALA A 167
ALA A 240
ILE A 244
 None
 0.90A 2h79A-5fxnA:
undetectable		 2h79A-5fxnA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5v FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF02465
(FliD_N)
PF07195
(FliD_C) 		5 ILE A 168
ALA A 166
ALA A 156
LEU A 201
ILE A 143
 None
 1.07A 2h79A-5h5vA:
undetectable		 2h79A-5h5vA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		5 ILE A 168
ALA A 166
ALA A 156
LEU A 201
ILE A 143
 None
 0.97A 2h79A-5h5wA:
undetectable		 2h79A-5h5wA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hra ASPARTATE/GLUTAMATE
RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		6 ILE A 104
ALA A 107
ARG A 110
ALA A 224
LEU A 102
ILE A  22
 None
 1.47A 2h79A-5hraA:
undetectable		 2h79A-5hraA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		5 ILE A 525
ILE A 526
ALA A 529
ALA A 562
ILE A 587
 None
 0.86A 2h79A-5i35A:
undetectable		 2h79A-5i35A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id4 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		5 ILE A 108
ILE A 107
ALA A 194
LEU A 183
ILE A 189
 None
 1.00A 2h79A-5id4A:
undetectable		 2h79A-5id4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 756
ILE B 755
ALA B 752
SER B 771
PHE B 814
 None
 1.03A 2h79A-5ip9B:
undetectable		 2h79A-5ip9B:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jen ANTI-SIGMA-V FACTOR
RSIV
LYSOZYME C

(Bacillus
subtilis;
Gallus gallus) 		PF00062
(Lys)
PF11738
(DUF3298)
PF13739
(DUF4163) 		5 ILE B  58
ALA A 167
ALA B  31
LEU B  56
LEU B  17
 None
 1.05A 2h79A-5jenB:
undetectable		 2h79A-5jenB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus) 		PF08534
(Redoxin) 		5 ALA A  39
MET A 127
SER A 122
LEU A   8
ILE A   2
 None
 1.02A 2h79A-5k1gA:
undetectable		 2h79A-5k1gA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		5 ILE A 690
ILE A 694
LEU A 713
ILE A 655
PHE A 698
 None
 1.10A 2h79A-5kcaA:
undetectable		 2h79A-5kcaA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		5 ILE A 192
ALA A 189
MET A 183
ALA A 235
ILE A 232
 None
 1.01A 2h79A-5tz8A:
undetectable		 2h79A-5tz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ILE A 170
ALA A 173
ALA A 146
LEU A  98
ILE A 137
 None
 1.00A 2h79A-5u4hA:
undetectable		 2h79A-5u4hA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u81 ACID CERAMIDASE
ISOFORM B

(Heterocephalus
glaber) 		no annotation 5 ILE A 282
ILE A 147
ALA A 337
LEU A 354
ILE A 357
 None
 1.09A 2h79A-5u81A:
undetectable		 2h79A-5u81A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 ILE A 168
ALA A 171
ALA A 146
LEU A  98
ILE A 137
 None
 1.05A 2h79A-5ujsA:
undetectable		 2h79A-5ujsA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A  82
ALA A  87
ALA A  50
LEU A  78
ILE A  41
 None
 1.09A 2h79A-5uzhA:
undetectable		 2h79A-5uzhA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 247
ALA B 229
ALA B 382
LEU B 249
LEU B 306
 None
 0.91A 2h79A-5xogB:
undetectable		 2h79A-5xogB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		5 ALA A 202
ALA A 179
LEU A 216
ILE A 176
HIS A 172
 None
 1.04A 2h79A-5xtoA:
undetectable		 2h79A-5xtoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 ILE A 312
ALA A 315
ALA A 247
SER A 245
ILE A 295
 None
 1.00A 2h79A-5xwbA:
undetectable		 2h79A-5xwbA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 ILE C3336
ALA C3349
LEU C3341
SER C3342
LEU C3301
 None
 0.95A 2h79A-5y3rC:
undetectable		 2h79A-5y3rC:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 130
ALA A 205
LEU A 160
ILE A 201
PHE A 128
 None
 1.05A 2h79A-6amsA:
undetectable		 2h79A-6amsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvd LIGHT CHAIN

(Clostridium
botulinum) 		no annotation 5 ILE A  45
ILE A  46
ALA A  36
ALA A 151
ILE A 190
 None
 0.93A 2h79A-6bvdA:
undetectable		 2h79A-6bvdA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA

(Naegleria
fowleri) 		no annotation 5 ALA A 191
ALA A 204
LEU A 144
ILE A 172
PHE A 185
 None
 0.95A 2h79A-6c87A:
undetectable		 2h79A-6c87A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus) 		no annotation 5 ILE H 284
ILE H 285
ALA H 288
ALA H 343
LEU H 324
 None
 1.10A 2h79A-6cfwH:
undetectable		 2h79A-6cfwH:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 5 ILE A 172
ALA A 175
ALA A 147
LEU A  99
PHE A 159
 None
 1.09A 2h79A-6cn1A:
undetectable		 2h79A-6cn1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 ILE A1477
ARG A1054
SER A1475
LEU A1448
ILE A1405
 None
 1.06A 2h79A-6fb3A:
undetectable		 2h79A-6fb3A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 6 ILE A 276
ILE A 277
ALA A 358
LEU A 338
ILE A 373
HIS A 392
 None
 1.47A 2h79A-6gu8A:
undetectable		 2h79A-6gu8A:
undetectable