SIMILAR PATTERNS OF AMINO ACIDS FOR 2H77_A_T3A1_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bsl | BACTERIAL LUCIFERASE (Vibrio harveyi) |
PF00296(Bac_luciferase) | 5 | ARG A 15ALA A 243LEU A 247ILE A 273PHE A 6 | None | 1.05A | 2h77A-1bslA:undetectable | 2h77A-1bslA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ej6 | LAMBDA1 (Reovirus sp.) |
no annotation | 5 | ILE B 743ALA B 594LEU B 595LEU B 886ILE B 882 | None | 0.83A | 2h77A-1ej6B:0.0 | 2h77A-1ej6B:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f6d | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Escherichiacoli) |
PF02350(Epimerase_2) | 5 | ILE A 225ALA A 228ALA A 233LEU A 267PHE A 222 | None | 1.10A | 2h77A-1f6dA:0.0 | 2h77A-1f6dA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jae | ALPHA-AMYLASE (Tenebriomolitor) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 5 | ILE A 24ALA A 25ARG A 83ILE A 348HIS A 362 | None | 1.09A | 2h77A-1jaeA:0.0 | 2h77A-1jaeA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jxk | ALPHA-AMYLASE,SALIVARY (Homo sapiens) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 5 | ILE A 24ALA A 25ARG A 85ILE A 367HIS A 381 | None | 1.13A | 2h77A-1jxkA:0.0 | 2h77A-1jxkA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khd | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Pectobacteriumcarotovorum) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | ILE A 186ALA A 68LEU A 34SER A 31LEU A 48 | None | 1.15A | 2h77A-1khdA:0.0 | 2h77A-1khdA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lth | L-LACTATEDEHYDROGENASE (T-AND R- STATETETRAMER COMPLEX) (Bifidobacteriumlongum) |
no annotation | 5 | MET T 52ALA T 26LEU T 22LEU T 37ILE T 35 | None | 1.11A | 2h77A-1lthT:0.0 | 2h77A-1lthT:24.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nav | HORMONE RECEPTORALPHA 1, THRA1 (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 222ALA A 225ARG A 228MET A 256MET A 259ALA A 263LEU A 276SER A 277LEU A 292ILE A 299HIS A 381PHE A 401 | IH5 A 600 (-4.3A)IH5 A 600 (-3.5A)IH5 A 600 (-4.2A)IH5 A 600 (-3.6A)IH5 A 600 (-4.7A)IH5 A 600 ( 3.8A)IH5 A 600 (-4.0A)IH5 A 600 (-4.3A)IH5 A 600 (-4.7A)IH5 A 600 (-4.7A)IH5 A 600 (-3.7A)IH5 A 600 (-4.4A) | 0.71A | 2h77A-1navA:37.8 | 2h77A-1navA:99.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nav | HORMONE RECEPTORALPHA 1, THRA1 (Homo sapiens) |
PF00104(Hormone_recep) | 6 | ILE A 222ALA A 225MET A 259LEU A 292ILE A 377PHE A 401 | IH5 A 600 (-4.3A)IH5 A 600 (-3.5A)IH5 A 600 (-4.7A)IH5 A 600 (-4.7A)NoneIH5 A 600 (-4.4A) | 1.35A | 2h77A-1navA:37.8 | 2h77A-1navA:99.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o1y | CONSERVEDHYPOTHETICAL PROTEINTM1158 (Thermotogamaritima) |
PF00117(GATase) | 5 | ILE A 20ARG A 179LEU A 14LEU A 85ILE A 87 | NoneSO4 A 409 (-4.1A)NoneNoneOCS A 88 ( 4.0A) | 1.02A | 2h77A-1o1yA:0.0 | 2h77A-1o1yA:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ose | PORCINEALPHA-AMYLASE (Sus scrofa) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 5 | ILE A 24ALA A 25ARG A 85ILE A 372HIS A 386 | None | 1.14A | 2h77A-1oseA:undetectable | 2h77A-1oseA:18.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q4x | THYROID HORMONERECEPTOR BETA-1 (Homo sapiens) |
PF00104(Hormone_recep) | 11 | ILE A 276ALA A 279ARG A 282MET A 310MET A 313ALA A 317LEU A 330LEU A 346ILE A 353HIS A 435PHE A 455 | G24 A 462 ( 4.3A)G24 A 462 (-3.5A)G24 A 462 ( 3.9A)G24 A 462 ( 3.8A)G24 A 462 ( 4.6A)G24 A 462 ( 4.1A)G24 A 462 ( 3.9A)G24 A 462 (-4.0A)NoneG24 A 462 (-3.9A)G24 A 462 (-3.8A) | 0.47A | 2h77A-1q4xA:37.1 | 2h77A-1q4xA:81.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q4x | THYROID HORMONERECEPTOR BETA-1 (Homo sapiens) |
PF00104(Hormone_recep) | 7 | ILE A 276ALA A 279ARG A 282MET A 313ALA A 317LEU A 341ILE A 353 | G24 A 462 ( 4.3A)G24 A 462 (-3.5A)G24 A 462 ( 3.9A)G24 A 462 ( 4.6A)G24 A 462 ( 4.1A)NoneNone | 1.41A | 2h77A-1q4xA:37.1 | 2h77A-1q4xA:81.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1thg | LIPASE 2 (Galactomycescandidus) |
PF00135(COesterase) | 5 | ILE A 228ALA A 229LEU A 187ILE A 128PHE A 336 | None | 1.16A | 2h77A-1thgA:undetectable | 2h77A-1thgA:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ty4 | APOPTOSIS REGULATORCED-9EGG LAYING DEFECTIVEEGL-1, PROGRAMMEDCELL DEATH ACTIVATOR (Caenorhabditiselegans) |
PF00452(Bcl-2)PF02180(BH4)PF11430(EGL-1) | 5 | ILE A 172ARG A 219MET A 231MET C 69ALA C 67 | None | 1.07A | 2h77A-1ty4A:undetectable | 2h77A-1ty4A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tzb | GLUCOSE-6-PHOSPHATEISOMERASE,CONJECTURAL (Pyrobaculumaerophilum) |
PF10432(bact-PGI_C) | 5 | ILE A 155ALA A 150ALA A 145LEU A 146ILE A 42 | None | 1.12A | 2h77A-1tzbA:undetectable | 2h77A-1tzbA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vqz | LIPOATE-PROTEINLIGASE, PUTATIVE (Streptococcuspneumoniae) |
PF03099(BPL_LplA_LipB)PF10437(Lip_prot_lig_C) | 5 | ILE A 270ALA A 263ALA A 326LEU A 306ILE A 323 | None | 1.04A | 2h77A-1vqzA:undetectable | 2h77A-1vqzA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w61 | B-CELL MITOGEN (Trypanosomacruzi) |
PF05544(Pro_racemase) | 5 | ILE A 365ALA A 363MET A 308SER A 191ILE A 222 | None | 0.97A | 2h77A-1w61A:undetectable | 2h77A-1w61A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wod | MODA (Escherichiacoli) |
PF13531(SBP_bac_11) | 5 | ALA A 10ALA A 16SER A 12LEU A 216ILE A 20 | WO4 A 234 (-3.3A)NoneWO4 A 234 ( 2.7A)NoneNone | 1.12A | 2h77A-1wodA:undetectable | 2h77A-1wodA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x8v | CYTOCHROME P450 51 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | ALA A 75ALA A 328LEU A 70LEU A 53ILE A 339 | None | 1.11A | 2h77A-1x8vA:2.8 | 2h77A-1x8vA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yqq | XANTHOSINEPHOSPHORYLASE (Escherichiacoli) |
PF01048(PNP_UDP_1) | 5 | ALA A 66ALA A 40LEU A 32ILE A 43PHE A 57 | None | 1.11A | 2h77A-1yqqA:undetectable | 2h77A-1yqqA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a9f | PUTATIVE MALICENZYME((S)-MALATE:NAD+OXIDOREDUCTASE(DECARBOXYLATING)) (Streptococcuspyogenes) |
PF00390(malic)PF03949(Malic_M) | 5 | ILE A 191ALA A 209LEU A 172ILE A 346PHE A 262 | None | 1.10A | 2h77A-2a9fA:undetectable | 2h77A-2a9fA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b8n | GLYCERATE KINASE,PUTATIVE (Thermotogamaritima) |
PF05161(MOFRL)PF13660(DUF4147) | 5 | ALA A 397ALA A 369SER A 395LEU A 383ILE A 335 | None | 1.16A | 2h77A-2b8nA:undetectable | 2h77A-2b8nA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eg5 | XANTHOSINEMETHYLTRANSFERASE (Coffeacanephora) |
PF03492(Methyltransf_7) | 5 | ILE A 246ALA A 245ALA A 238LEU A 265PHE A 329 | NoneNoneXTS A 502 ( 4.3A)NoneNone | 1.13A | 2h77A-2eg5A:undetectable | 2h77A-2eg5A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h4t | CARNITINEO-PALMITOYLTRANSFERASE II, MITOCHONDRIAL (Rattusnorvegicus) |
PF00755(Carn_acyltransf) | 5 | ALA A 367MET A 342LEU A 599ILE A 443HIS A 337 | NoneNoneD12 A1703 (-4.2A)NoneNone | 1.06A | 2h77A-2h4tA:undetectable | 2h77A-2h4tA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i6u | ORNITHINECARBAMOYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | ALA A 115ALA A 43LEU A 91LEU A 78ILE A 45 | None | 1.10A | 2h77A-2i6uA:undetectable | 2h77A-2i6uA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i6u | ORNITHINECARBAMOYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | ALA A 115LEU A 91SER A 92LEU A 78ILE A 45 | None | 1.02A | 2h77A-2i6uA:undetectable | 2h77A-2i6uA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jrb | ORF 1 PROTEIN (Mus musculus) |
PF17490(Tnp_22_dsRBD) | 5 | ILE A 352ALA A 348LEU A 343LEU A 307ILE A 324 | None | 1.05A | 2h77A-2jrbA:undetectable | 2h77A-2jrbA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lao | LYSINE, ARGININE,ORNITHINE-BINDINGPROTEIN (Salmonellaenterica) |
PF00497(SBP_bac_3) | 6 | ALA A 209MET A 37ALA A 66LEU A 199LEU A 87ILE A 68 | None | 1.32A | 2h77A-2laoA:undetectable | 2h77A-2laoA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pef | SERINE PROTEASEINHIBITOR (Caldanaerobactersubterraneus) |
PF00079(Serpin) | 5 | ILE A 357ALA A 336MET A 107ALA A 110LEU A 328 | None | 1.09A | 2h77A-2pefA:undetectable | 2h77A-2pefA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pp3 | L-TALARATE/GALACTARATE DEHYDRATASE (Salmonellaenterica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 96ALA A 131ALA A 65LEU A 33ILE A 67 | None | 1.09A | 2h77A-2pp3A:undetectable | 2h77A-2pp3A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pwq | UBIQUITINCONJUGATING ENZYME (Plasmodiumyoelii) |
PF00179(UQ_con) | 5 | ILE A 86LEU A 91LEU A 105ILE A 101PHE A 70 | None | 1.11A | 2h77A-2pwqA:undetectable | 2h77A-2pwqA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyg | RIBULOSEBISPHOSPHATECARBOXYLASE-LIKEPROTEIN 2 (Rhodopseudomonaspalustris) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ILE A 98ALA A 65ALA A 115SER A 46LEU A 132 | None | 1.14A | 2h77A-2qygA:undetectable | 2h77A-2qygA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vg8 | HYDROQUINONEGLUCOSYLTRANSFERASE (Arabidopsisthaliana) |
PF00201(UDPGT) | 5 | ILE A 42ALA A 43ALA A 123LEU A 97SER A 93 | EDO A1483 (-4.8A)NoneNoneNoneNone | 1.12A | 2h77A-2vg8A:undetectable | 2h77A-2vg8A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xfg | ENDOGLUCANASE 1 (Ruminiclostridiumthermocellum) |
PF00942(CBM_3) | 5 | ILE B 478ALA B 468LEU B 588ILE B 599PHE B 577 | None | 1.14A | 2h77A-2xfgB:undetectable | 2h77A-2xfgB:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1j | CELL CYCLECHECKPOINT PROTEINRAD1 (Homo sapiens) |
PF02144(Rad1) | 6 | ILE C 84ALA C 40ALA C 63LEU C 31ILE C 65PHE C 82 | None | 1.39A | 2h77A-3a1jC:undetectable | 2h77A-3a1jC:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgg | SAM-DEPENDENTMETHYLTRANSFERASE (Corynebacteriumglutamicum) |
PF13649(Methyltransf_25) | 5 | ILE A 144ALA A 142ALA A 135LEU A 97ILE A 102 | NHE A 195 ( 4.5A)NoneNoneNHE A 195 (-3.8A)EDO A 200 (-4.4A) | 1.06A | 2h77A-3cggA:undetectable | 2h77A-3cggA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A 80ALA A 81ARG A 85LEU A 107ILE A 262 | None | 1.10A | 2h77A-3cmuA:undetectable | 2h77A-3cmuA:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A1080ALA A1081ARG A1085LEU A1107ILE A1262 | None | 1.11A | 2h77A-3cmuA:undetectable | 2h77A-3cmuA:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A2080ALA A2081ARG A2085LEU A2107ILE A2262 | None | 1.10A | 2h77A-3cmuA:undetectable | 2h77A-3cmuA:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A3080ALA A3081ARG A3085LEU A3107ILE A3262 | None | 1.11A | 2h77A-3cmuA:undetectable | 2h77A-3cmuA:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A4080ALA A4081ARG A4085LEU A4107ILE A4262 | None | 1.11A | 2h77A-3cmuA:undetectable | 2h77A-3cmuA:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | ILE A5080ALA A5081ARG A5085LEU A5107ILE A5262 | None | 1.10A | 2h77A-3cmuA:undetectable | 2h77A-3cmuA:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE A 90ALA A 51LEU A 112LEU A 34ILE A 73 | None | 1.08A | 2h77A-3hveA:undetectable | 2h77A-3hveA:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuv | UNCHARACTERIZED TETRFAMILY PROTEIN (Streptomycescoelicolor) |
PF00440(TetR_N) | 5 | ILE A 13ALA A 16ARG A 19LEU A 42HIS A 31 | None | 1.13A | 2h77A-3iuvA:undetectable | 2h77A-3iuvA:24.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwp | COPPER HOMEOSTASISPROTEIN CUTC HOMOLOG (Homo sapiens) |
PF03932(CutC) | 5 | ILE A 189ALA A 178LEU A 182LEU A 213ILE A 204 | None | 1.06A | 2h77A-3iwpA:undetectable | 2h77A-3iwpA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ot5 | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Listeriamonocytogenes) |
PF02350(Epimerase_2) | 5 | ILE A 4ALA A 25LEU A 26LEU A 95PHE A 368 | None | 1.16A | 2h77A-3ot5A:undetectable | 2h77A-3ot5A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppi | 3-HYDROXYACYL-COADEHYDROGENASE TYPE-2 (Mycobacteriumavium) |
PF13561(adh_short_C2) | 5 | ILE A 12ALA A 76SER A 10LEU A 147ILE A 188 | None | 1.12A | 2h77A-3ppiA:undetectable | 2h77A-3ppiA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0s | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Campylobacterjejuni) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ILE A 46ALA A 44ALA A 8LEU A 16ILE A 4 | None | 1.15A | 2h77A-3r0sA:undetectable | 2h77A-3r0sA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tp9 | BETA-LACTAMASE ANDRHODANESE DOMAINPROTEIN (Alicyclobacillusacidocaldarius) |
PF00581(Rhodanese)PF00753(Lactamase_B) | 5 | ALA A 322ARG A 249ALA A 316LEU A 342ILE A 306 | None | 1.10A | 2h77A-3tp9A:undetectable | 2h77A-3tp9A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tx1 | UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINEREDUCTASE (Listeriamonocytogenes) |
PF01565(FAD_binding_4)PF02873(MurB_C) | 5 | ILE A 86ALA A 99ALA A 129LEU A 101ILE A 141 | NoneNoneFAD A 299 (-4.0A)NoneNone | 1.10A | 2h77A-3tx1A:undetectable | 2h77A-3tx1A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u80 | 3-DEHYDROQUINATEDEHYDRATASE, TYPE II (Bifidobacteriumlongum) |
PF01220(DHquinase_II) | 5 | ILE A 5ALA A 64MET A 57ALA A 89LEU A 99 | None | 1.04A | 2h77A-3u80A:undetectable | 2h77A-3u80A:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uqz | DNA PROCESSINGPROTEIN DPRA (Streptococcuspneumoniae) |
PF02481(DNA_processg_A) | 5 | ILE A 247ALA A 222ALA A 150LEU A 132ILE A 138 | None | 1.14A | 2h77A-3uqzA:undetectable | 2h77A-3uqzA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vm5 | ALPHA-AMYLASE (Oryzias latipes) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 5 | ILE A 24ALA A 25ARG A 85ILE A 373HIS A 387 | None | 1.12A | 2h77A-3vm5A:undetectable | 2h77A-3vm5A:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3voc | BETA/ALPHA-AMYLASE (Paenibacilluspolymyxa) |
PF01373(Glyco_hydro_14) | 5 | ALA A 264ALA A 315LEU A 317LEU A 164HIS A 256 | None | 1.12A | 2h77A-3vocA:undetectable | 2h77A-3vocA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bb9 | GLUCOKINASEREGULATORY PROTEIN (Homo sapiens) |
no annotation | 5 | ILE A 535ALA A 574LEU A 523HIS A 560PHE A 7 | None | 1.12A | 2h77A-4bb9A:undetectable | 2h77A-4bb9A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4efc | ADENYLOSUCCINATELYASE (Trypanosomabrucei) |
PF00206(Lyase_1)PF08328(ASL_C) | 5 | ILE A 154ALA A 153LEU A 361LEU A 336HIS A 280 | None | 1.12A | 2h77A-4efcA:undetectable | 2h77A-4efcA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4c | MULTIDRUG RESISTANCEPROTEIN PGP-1 (Caenorhabditiselegans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | ILE A 870ALA A 869ALA A1047LEU A 829ILE A1051 | None | 1.08A | 2h77A-4f4cA:undetectable | 2h77A-4f4cA:11.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4c | MULTIDRUG RESISTANCEPROTEIN PGP-1 (Caenorhabditiselegans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | ILE A1272ALA A1286LEU A1108LEU A1098ILE A1293 | None | 1.16A | 2h77A-4f4cA:undetectable | 2h77A-4f4cA:11.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fhr | FLAGELLAR MOTORSWITCH PROTEIN FLIG (Thermotogamaritima) |
PF01706(FliG_C)PF14841(FliG_M) | 5 | ALA B 132ALA B 201LEU B 159LEU B 227ILE B 198 | None | 1.12A | 2h77A-4fhrB:undetectable | 2h77A-4fhrB:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fyu | THIOREDOXIN (Wuchereriabancrofti) |
PF13905(Thioredoxin_8) | 5 | ILE A 8ALA A 6LEU A 24LEU A 32ILE A 114 | None | 1.15A | 2h77A-4fyuA:undetectable | 2h77A-4fyuA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2n | D-ISOMER SPECIFIC2-HYDROXYACIDDEHYDROGENASE,NAD-BINDING (Polaromonas sp.JS666) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | ILE A 178MET A 160ALA A 213LEU A 211ILE A 163 | None | 0.96A | 2h77A-4g2nA:undetectable | 2h77A-4g2nA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gtn | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Acinetobactersp. ADP1) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | ILE A 196ALA A 78MET A 45LEU A 36ILE A 23 | None | 1.00A | 2h77A-4gtnA:undetectable | 2h77A-4gtnA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jzy | CRYPTOCHROME-1 (Drosophilamelanogaster) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 5 | ILE A 9ALA A 26ALA A 183LEU A 71PHE A 11 | None | 1.14A | 2h77A-4jzyA:undetectable | 2h77A-4jzyA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpg | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | ILE A 363ALA A 388ALA A 77LEU A 346ILE A 74 | None | 1.03A | 2h77A-4kpgA:undetectable | 2h77A-4kpgA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lds | BICYCLOMYCINRESISTANCE PROTEINTCAB (Staphylococcusepidermidis) |
PF00083(Sugar_tr) | 5 | ILE A 248ALA A 247SER A 376ILE A 56PHE A 252 | None | 1.08A | 2h77A-4ldsA:undetectable | 2h77A-4ldsA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m38 | PROTEIN ARGININEN-METHYLTRANSFERASE7 (Trypanosomabrucei) |
PF06325(PrmA) | 5 | ILE A 266MET A 300LEU A 369ILE A 244PHE A 287 | None | 1.13A | 2h77A-4m38A:undetectable | 2h77A-4m38A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1o | RIBONUCLEASE L (Sus scrofa) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A)PF12796(Ank_2)PF13857(Ank_5) | 5 | ALA A 167ARG A 153ALA A 173LEU A 223ILE A 219 | 25L A1000 ( 4.4A)25L A1000 (-3.9A)NoneNoneNone | 1.16A | 2h77A-4o1oA:undetectable | 2h77A-4o1oA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oh7 | ORNITHINECARBAMOYLTRANSFERASE (Brucellamelitensis) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | ILE A 153ALA A 296LEU A 25LEU A 13PHE A 180 | None | 1.14A | 2h77A-4oh7A:undetectable | 2h77A-4oh7A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qmg | STAPHYLOCOCCALNUCLEASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00565(SNase) | 5 | ILE A 180ALA A 210LEU A 265ILE A 263HIS A 190 | None | 1.03A | 2h77A-4qmgA:undetectable | 2h77A-4qmgA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r5d | LEUCINE RICH REPEATPROTEIN (syntheticconstruct) |
PF12354(Internalin_N)PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 5 | ILE A 362ALA A 363LEU A 394LEU A 406ILE A 419 | None | 1.07A | 2h77A-4r5dA:undetectable | 2h77A-4r5dA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ras | OXIDOREDUCTASE,NAD-BINDING/IRON-SULFUR CLUSTER-BINDINGPROTEIN (Nitratireductorpacificus) |
PF12838(Fer4_7)PF13486(Dehalogenase) | 5 | ILE A 432ALA A 365ALA A 358LEU A 46ILE A 137 | None | 1.09A | 2h77A-4rasA:undetectable | 2h77A-4rasA:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rku | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Pisum sativum) |
PF00223(PsaA_PsaB) | 5 | MET A 418ALA A 356SER A 359LEU A 432ILE A 349 | NoneBCR A6007 ( 3.8A)BCR A6008 ( 3.7A)CLA A1122 ( 4.8A)None | 1.15A | 2h77A-4rkuA:undetectable | 2h77A-4rkuA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x4w | CCA TRNANUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL (Homo sapiens) |
PF01743(PolyA_pol)PF12627(PolyA_pol_RNAbd) | 5 | ALA A 70ALA A 87LEU A 89LEU A 33ILE A 96 | None | 1.14A | 2h77A-4x4wA:undetectable | 2h77A-4x4wA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xq7 | 2'-5'-OLIGOADENYLATESYNTHASE-LIKEPROTEIN (Homo sapiens) |
PF10421(OAS1_C) | 5 | ILE A 108LEU A 126LEU A 118ILE A 140PHE A 49 | None | 1.16A | 2h77A-4xq7A:undetectable | 2h77A-4xq7A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yfh | DNA-BINDING PROTEINHU-ALPHA (Escherichiacoli) |
PF00216(Bac_DNA_binding) | 5 | ILE A 32ALA A 31ALA A 24ILE A 10PHE A 50 | None | 1.08A | 2h77A-4yfhA:undetectable | 2h77A-4yfhA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0k | LABDANE-RELATEDDITERPENE SYNTHASE (Streptomycessp.) |
no annotation | 5 | ILE A 199ALA A 300LEU A 201ILE A 304PHE A 139 | None | 1.05A | 2h77A-5a0kA:undetectable | 2h77A-5a0kA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ah4 | DNA POLYMERASE IIISUBUNIT BETA (Mycolicibacteriumsmegmatis) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 5 | ILE A 273ALA A 271MET A 297ALA A 361LEU A 338 | None | 1.05A | 2h77A-5ah4A:undetectable | 2h77A-5ah4A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | PROBABLE TRANSLATIONINITIATION FACTOREIF-2B SUBUNITEPSILON (Schizosaccharomycespombe) |
PF00132(Hexapep)PF00483(NTP_transferase) | 5 | ILE I 414ALA I 400ALA I 365LEU I 384ILE I 362 | None | 1.09A | 2h77A-5b04I:undetectable | 2h77A-5b04I:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e5u | CONTACTIN-6 (Mus musculus) |
PF13927(Ig_3) | 5 | ILE B 237ALA B 239SER B 243LEU B 282ILE B 273 | None | 0.93A | 2h77A-5e5uB:undetectable | 2h77A-5e5uB:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ege | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 6 (Mus musculus) |
PF01663(Phosphodiest) | 5 | ILE A 187ALA A 173MET A 220LEU A 237PHE A 166 | None | 0.91A | 2h77A-5egeA:undetectable | 2h77A-5egeA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eku | ARGININEN-METHYLTRANSFERASE,PUTATIVE (Trypanosomabrucei) |
PF06325(PrmA) | 5 | ILE A 266MET A 300LEU A 369ILE A 244PHE A 287 | None | 1.03A | 2h77A-5ekuA:undetectable | 2h77A-5ekuA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5elz | TYPE II PANTOTHENATEKINASE (Staphylococcusaureus) |
PF03630(Fumble) | 5 | ALA A 262ALA A 65LEU A 49LEU A 39ILE A 63 | None | 1.00A | 2h77A-5elzA:undetectable | 2h77A-5elzA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5itw | DIHYDROANTICAPSIN7-DEHYDROGENASE (Bacillussubtilis) |
PF13561(adh_short_C2) | 5 | ALA A 72MET A 120ALA A 124LEU A 83ILE A 136 | None | 1.09A | 2h77A-5itwA:undetectable | 2h77A-5itwA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1g | 1-CYS PEROXIREDOXIN (Vibriovulnificus) |
PF08534(Redoxin) | 5 | ALA A 39MET A 127SER A 122LEU A 8ILE A 2 | None | 0.95A | 2h77A-5k1gA:undetectable | 2h77A-5k1gA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t9c | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Bacillussubtilis) |
PF03009(GDPD) | 5 | ILE E 227ALA E 223MET E 216MET E 219LEU E 256 | None | 1.01A | 2h77A-5t9cE:undetectable | 2h77A-5t9cE:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tz8 | GLYCOSYL TRANSFERASE (Staphylococcusaureus) |
PF00535(Glycos_transf_2) | 5 | ILE A 192ALA A 189MET A 183ALA A 235ILE A 232 | None | 0.98A | 2h77A-5tz8A:undetectable | 2h77A-5tz8A:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4h | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | ILE A 170ALA A 173ALA A 146LEU A 98ILE A 137 | None | 1.02A | 2h77A-5u4hA:undetectable | 2h77A-5u4hA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ujs | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Campylobacterjejuni) |
PF00275(EPSP_synthase) | 5 | ILE A 168ALA A 171ALA A 146LEU A 98ILE A 137 | None | 1.06A | 2h77A-5ujsA:undetectable | 2h77A-5ujsA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uzh | NAFOA.00085.B (Naegleriafowleri) |
PF16363(GDP_Man_Dehyd) | 5 | ILE A 82ALA A 87ALA A 50LEU A 78ILE A 41 | None | 1.07A | 2h77A-5uzhA:undetectable | 2h77A-5uzhA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v7o | NOSK (Streptomycesactuosus) |
PF12697(Abhydrolase_6) | 5 | ILE A 99ALA A 113LEU A 123SER A 122PHE A 46 | None | 1.11A | 2h77A-5v7oA:undetectable | 2h77A-5v7oA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5whr | INDOLEAMINE2,3-DIOXYGENASE 1 (Homo sapiens) |
no annotation | 5 | ILE A 42ALA A 43ALA A 79LEU A 83LEU A 65 | None | 0.98A | 2h77A-5whrA:undetectable | 2h77A-5whrA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x9u | THERMOSOME, ALPHASUBUNIT (Carboxydothermushydrogenoformans) |
no annotation | 5 | ALA A 92ALA A 492LEU A 99LEU A 124ILE A 493 | None | 1.16A | 2h77A-5x9uA:undetectable | 2h77A-5x9uA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Komagataellaphaffii) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | ILE B 247ALA B 229ALA B 382LEU B 249LEU B 306 | None | 0.89A | 2h77A-5xogB:undetectable | 2h77A-5xogB:12.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xto | FAD-LINKEDSULFHYDRYL OXIDASE (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF05214(Baculo_p33) | 5 | ALA A 202ALA A 179LEU A 216ILE A 176HIS A 172 | None | 1.01A | 2h77A-5xtoA:undetectable | 2h77A-5xtoA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwb | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Colwelliapsychrerythraea) |
PF00275(EPSP_synthase) | 5 | ILE A 312ALA A 315ALA A 247SER A 245ILE A 295 | None | 0.99A | 2h77A-5xwbA:undetectable | 2h77A-5xwbA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ams | BETA SLIDING CLAMP (Pseudomonasaeruginosa) |
no annotation | 5 | ILE A 130ALA A 205LEU A 160ILE A 201PHE A 128 | None | 0.99A | 2h77A-6amsA:undetectable | 2h77A-6amsA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cip | PYRUVATE-FERREDOXINOXIDOREDUCTASE (Moorellathermoacetica) |
no annotation | 5 | ILE A 566ALA A 567ALA A 575LEU A 606ILE A 576 | None | 1.14A | 2h77A-6cipA:undetectable | 2h77A-6cipA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cn1 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Pseudomonasputida) |
no annotation | 5 | ILE A 172ALA A 175ALA A 147LEU A 99PHE A 159 | None | 1.08A | 2h77A-6cn1A:undetectable | 2h77A-6cn1A:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gun | - (-) |
no annotation | 5 | ILE A 87ARG A 134ALA A 164LEU A 151LEU A 107 | None | 1.16A | 2h77A-6gunA:undetectable | 2h77A-6gunA:undetectable |