SIMILAR PATTERNS OF AMINO ACIDS FOR 2H77_A_T3A1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsl BACTERIAL LUCIFERASE

(Vibrio harveyi)
PF00296
(Bac_luciferase)
5 ARG A  15
ALA A 243
LEU A 247
ILE A 273
PHE A   6
None
1.05A 2h77A-1bslA:
undetectable
2h77A-1bslA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.)
no annotation 5 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
None
0.83A 2h77A-1ej6B:
0.0
2h77A-1ej6B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Escherichia
coli)
PF02350
(Epimerase_2)
5 ILE A 225
ALA A 228
ALA A 233
LEU A 267
PHE A 222
None
1.10A 2h77A-1f6dA:
0.0
2h77A-1f6dA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
5 ILE A  24
ALA A  25
ARG A  83
ILE A 348
HIS A 362
None
1.09A 2h77A-1jaeA:
0.0
2h77A-1jaeA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY


(Homo sapiens)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
5 ILE A  24
ALA A  25
ARG A  85
ILE A 367
HIS A 381
None
1.13A 2h77A-1jxkA:
0.0
2h77A-1jxkA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Pectobacterium
carotovorum)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
5 ILE A 186
ALA A  68
LEU A  34
SER A  31
LEU A  48
None
1.15A 2h77A-1khdA:
0.0
2h77A-1khdA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)


(Bifidobacterium
longum)
no annotation 5 MET T  52
ALA T  26
LEU T  22
LEU T  37
ILE T  35
None
1.11A 2h77A-1lthT:
0.0
2h77A-1lthT:
24.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1


(Homo sapiens)
PF00104
(Hormone_recep)
12 ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
ALA A 263
LEU A 276
SER A 277
LEU A 292
ILE A 299
HIS A 381
PHE A 401
IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-4.4A)
0.71A 2h77A-1navA:
37.8
2h77A-1navA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1


(Homo sapiens)
PF00104
(Hormone_recep)
6 ILE A 222
ALA A 225
MET A 259
LEU A 292
ILE A 377
PHE A 401
IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-4.4A)
1.35A 2h77A-1navA:
37.8
2h77A-1navA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158


(Thermotoga
maritima)
PF00117
(GATase)
5 ILE A  20
ARG A 179
LEU A  14
LEU A  85
ILE A  87
None
SO4  A 409 (-4.1A)
None
None
OCS  A  88 ( 4.0A)
1.02A 2h77A-1o1yA:
0.0
2h77A-1o1yA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE


(Sus scrofa)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
5 ILE A  24
ALA A  25
ARG A  85
ILE A 372
HIS A 386
None
1.14A 2h77A-1oseA:
undetectable
2h77A-1oseA:
18.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1


(Homo sapiens)
PF00104
(Hormone_recep)
11 ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
0.47A 2h77A-1q4xA:
37.1
2h77A-1q4xA:
81.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1


(Homo sapiens)
PF00104
(Hormone_recep)
7 ILE A 276
ALA A 279
ARG A 282
MET A 313
ALA A 317
LEU A 341
ILE A 353
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
None
None
1.41A 2h77A-1q4xA:
37.1
2h77A-1q4xA:
81.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus)
PF00135
(COesterase)
5 ILE A 228
ALA A 229
LEU A 187
ILE A 128
PHE A 336
None
1.16A 2h77A-1thgA:
undetectable
2h77A-1thgA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR


(Caenorhabditis
elegans)
PF00452
(Bcl-2)
PF02180
(BH4)
PF11430
(EGL-1)
5 ILE A 172
ARG A 219
MET A 231
MET C  69
ALA C  67
None
1.07A 2h77A-1ty4A:
undetectable
2h77A-1ty4A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL


(Pyrobaculum
aerophilum)
PF10432
(bact-PGI_C)
5 ILE A 155
ALA A 150
ALA A 145
LEU A 146
ILE A  42
None
1.12A 2h77A-1tzbA:
undetectable
2h77A-1tzbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE


(Streptococcus
pneumoniae)
PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C)
5 ILE A 270
ALA A 263
ALA A 326
LEU A 306
ILE A 323
None
1.04A 2h77A-1vqzA:
undetectable
2h77A-1vqzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi)
PF05544
(Pro_racemase)
5 ILE A 365
ALA A 363
MET A 308
SER A 191
ILE A 222
None
0.97A 2h77A-1w61A:
undetectable
2h77A-1w61A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli)
PF13531
(SBP_bac_11)
5 ALA A  10
ALA A  16
SER A  12
LEU A 216
ILE A  20
WO4  A 234 (-3.3A)
None
WO4  A 234 ( 2.7A)
None
None
1.12A 2h77A-1wodA:
undetectable
2h77A-1wodA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis)
PF00067
(p450)
5 ALA A  75
ALA A 328
LEU A  70
LEU A  53
ILE A 339
None
1.11A 2h77A-1x8vA:
2.8
2h77A-1x8vA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqq XANTHOSINE
PHOSPHORYLASE


(Escherichia
coli)
PF01048
(PNP_UDP_1)
5 ALA A  66
ALA A  40
LEU A  32
ILE A  43
PHE A  57
None
1.11A 2h77A-1yqqA:
undetectable
2h77A-1yqqA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))


(Streptococcus
pyogenes)
PF00390
(malic)
PF03949
(Malic_M)
5 ILE A 191
ALA A 209
LEU A 172
ILE A 346
PHE A 262
None
1.10A 2h77A-2a9fA:
undetectable
2h77A-2a9fA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE


(Thermotoga
maritima)
PF05161
(MOFRL)
PF13660
(DUF4147)
5 ALA A 397
ALA A 369
SER A 395
LEU A 383
ILE A 335
None
1.16A 2h77A-2b8nA:
undetectable
2h77A-2b8nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE


(Coffea
canephora)
PF03492
(Methyltransf_7)
5 ILE A 246
ALA A 245
ALA A 238
LEU A 265
PHE A 329
None
None
XTS  A 502 ( 4.3A)
None
None
1.13A 2h77A-2eg5A:
undetectable
2h77A-2eg5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL


(Rattus
norvegicus)
PF00755
(Carn_acyltransf)
5 ALA A 367
MET A 342
LEU A 599
ILE A 443
HIS A 337
None
None
D12  A1703 (-4.2A)
None
None
1.06A 2h77A-2h4tA:
undetectable
2h77A-2h4tA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE


(Mycobacterium
tuberculosis)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 ALA A 115
ALA A  43
LEU A  91
LEU A  78
ILE A  45
None
1.10A 2h77A-2i6uA:
undetectable
2h77A-2i6uA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE


(Mycobacterium
tuberculosis)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 ALA A 115
LEU A  91
SER A  92
LEU A  78
ILE A  45
None
1.02A 2h77A-2i6uA:
undetectable
2h77A-2i6uA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrb ORF 1 PROTEIN

(Mus musculus)
PF17490
(Tnp_22_dsRBD)
5 ILE A 352
ALA A 348
LEU A 343
LEU A 307
ILE A 324
None
1.05A 2h77A-2jrbA:
undetectable
2h77A-2jrbA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN


(Salmonella
enterica)
PF00497
(SBP_bac_3)
6 ALA A 209
MET A  37
ALA A  66
LEU A 199
LEU A  87
ILE A  68
None
1.32A 2h77A-2laoA:
undetectable
2h77A-2laoA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR


(Caldanaerobacter
subterraneus)
PF00079
(Serpin)
5 ILE A 357
ALA A 336
MET A 107
ALA A 110
LEU A 328
None
1.09A 2h77A-2pefA:
undetectable
2h77A-2pefA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE


(Salmonella
enterica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A  96
ALA A 131
ALA A  65
LEU A  33
ILE A  67
None
1.09A 2h77A-2pp3A:
undetectable
2h77A-2pp3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwq UBIQUITIN
CONJUGATING ENZYME


(Plasmodium
yoelii)
PF00179
(UQ_con)
5 ILE A  86
LEU A  91
LEU A 105
ILE A 101
PHE A  70
None
1.11A 2h77A-2pwqA:
undetectable
2h77A-2pwqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2


(Rhodopseudomonas
palustris)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 ILE A  98
ALA A  65
ALA A 115
SER A  46
LEU A 132
None
1.14A 2h77A-2qygA:
undetectable
2h77A-2qygA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE


(Arabidopsis
thaliana)
PF00201
(UDPGT)
5 ILE A  42
ALA A  43
ALA A 123
LEU A  97
SER A  93
EDO  A1483 (-4.8A)
None
None
None
None
1.12A 2h77A-2vg8A:
undetectable
2h77A-2vg8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum)
PF00942
(CBM_3)
5 ILE B 478
ALA B 468
LEU B 588
ILE B 599
PHE B 577
None
1.14A 2h77A-2xfgB:
undetectable
2h77A-2xfgB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1


(Homo sapiens)
PF02144
(Rad1)
6 ILE C  84
ALA C  40
ALA C  63
LEU C  31
ILE C  65
PHE C  82
None
1.39A 2h77A-3a1jC:
undetectable
2h77A-3a1jC:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgg SAM-DEPENDENT
METHYLTRANSFERASE


(Corynebacterium
glutamicum)
PF13649
(Methyltransf_25)
5 ILE A 144
ALA A 142
ALA A 135
LEU A  97
ILE A 102
NHE  A 195 ( 4.5A)
None
None
NHE  A 195 (-3.8A)
EDO  A 200 (-4.4A)
1.06A 2h77A-3cggA:
undetectable
2h77A-3cggA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A  80
ALA A  81
ARG A  85
LEU A 107
ILE A 262
None
1.10A 2h77A-3cmuA:
undetectable
2h77A-3cmuA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A1080
ALA A1081
ARG A1085
LEU A1107
ILE A1262
None
1.11A 2h77A-3cmuA:
undetectable
2h77A-3cmuA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A2080
ALA A2081
ARG A2085
LEU A2107
ILE A2262
None
1.10A 2h77A-3cmuA:
undetectable
2h77A-3cmuA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A3080
ALA A3081
ARG A3085
LEU A3107
ILE A3262
None
1.11A 2h77A-3cmuA:
undetectable
2h77A-3cmuA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A4080
ALA A4081
ARG A4085
LEU A4107
ILE A4262
None
1.11A 2h77A-3cmuA:
undetectable
2h77A-3cmuA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A5080
ALA A5081
ARG A5085
LEU A5107
ILE A5262
None
1.10A 2h77A-3cmuA:
undetectable
2h77A-3cmuA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE A  90
ALA A  51
LEU A 112
LEU A  34
ILE A  73
None
1.08A 2h77A-3hveA:
undetectable
2h77A-3hveA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuv UNCHARACTERIZED TETR
FAMILY PROTEIN


(Streptomyces
coelicolor)
PF00440
(TetR_N)
5 ILE A  13
ALA A  16
ARG A  19
LEU A  42
HIS A  31
None
1.13A 2h77A-3iuvA:
undetectable
2h77A-3iuvA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG


(Homo sapiens)
PF03932
(CutC)
5 ILE A 189
ALA A 178
LEU A 182
LEU A 213
ILE A 204
None
1.06A 2h77A-3iwpA:
undetectable
2h77A-3iwpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Listeria
monocytogenes)
PF02350
(Epimerase_2)
5 ILE A   4
ALA A  25
LEU A  26
LEU A  95
PHE A 368
None
1.16A 2h77A-3ot5A:
undetectable
2h77A-3ot5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2


(Mycobacterium
avium)
PF13561
(adh_short_C2)
5 ILE A  12
ALA A  76
SER A  10
LEU A 147
ILE A 188
None
1.12A 2h77A-3ppiA:
undetectable
2h77A-3ppiA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Campylobacter
jejuni)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  46
ALA A  44
ALA A   8
LEU A  16
ILE A   4
None
1.15A 2h77A-3r0sA:
undetectable
2h77A-3r0sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN


(Alicyclobacillus
acidocaldarius)
PF00581
(Rhodanese)
PF00753
(Lactamase_B)
5 ALA A 322
ARG A 249
ALA A 316
LEU A 342
ILE A 306
None
1.10A 2h77A-3tp9A:
undetectable
2h77A-3tp9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE


(Listeria
monocytogenes)
PF01565
(FAD_binding_4)
PF02873
(MurB_C)
5 ILE A  86
ALA A  99
ALA A 129
LEU A 101
ILE A 141
None
None
FAD  A 299 (-4.0A)
None
None
1.10A 2h77A-3tx1A:
undetectable
2h77A-3tx1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u80 3-DEHYDROQUINATE
DEHYDRATASE, TYPE II


(Bifidobacterium
longum)
PF01220
(DHquinase_II)
5 ILE A   5
ALA A  64
MET A  57
ALA A  89
LEU A  99
None
1.04A 2h77A-3u80A:
undetectable
2h77A-3u80A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA


(Streptococcus
pneumoniae)
PF02481
(DNA_processg_A)
5 ILE A 247
ALA A 222
ALA A 150
LEU A 132
ILE A 138
None
1.14A 2h77A-3uqzA:
undetectable
2h77A-3uqzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
5 ILE A  24
ALA A  25
ARG A  85
ILE A 373
HIS A 387
None
1.12A 2h77A-3vm5A:
undetectable
2h77A-3vm5A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa)
PF01373
(Glyco_hydro_14)
5 ALA A 264
ALA A 315
LEU A 317
LEU A 164
HIS A 256
None
1.12A 2h77A-3vocA:
undetectable
2h77A-3vocA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN


(Homo sapiens)
no annotation 5 ILE A 535
ALA A 574
LEU A 523
HIS A 560
PHE A   7
None
1.12A 2h77A-4bb9A:
undetectable
2h77A-4bb9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE


(Trypanosoma
brucei)
PF00206
(Lyase_1)
PF08328
(ASL_C)
5 ILE A 154
ALA A 153
LEU A 361
LEU A 336
HIS A 280
None
1.12A 2h77A-4efcA:
undetectable
2h77A-4efcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1


(Caenorhabditis
elegans)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
5 ILE A 870
ALA A 869
ALA A1047
LEU A 829
ILE A1051
None
1.08A 2h77A-4f4cA:
undetectable
2h77A-4f4cA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1


(Caenorhabditis
elegans)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
5 ILE A1272
ALA A1286
LEU A1108
LEU A1098
ILE A1293
None
1.16A 2h77A-4f4cA:
undetectable
2h77A-4f4cA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG


(Thermotoga
maritima)
PF01706
(FliG_C)
PF14841
(FliG_M)
5 ALA B 132
ALA B 201
LEU B 159
LEU B 227
ILE B 198
None
1.12A 2h77A-4fhrB:
undetectable
2h77A-4fhrB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyu THIOREDOXIN

(Wuchereria
bancrofti)
PF13905
(Thioredoxin_8)
5 ILE A   8
ALA A   6
LEU A  24
LEU A  32
ILE A 114
None
1.15A 2h77A-4fyuA:
undetectable
2h77A-4fyuA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING


(Polaromonas sp.
JS666)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 ILE A 178
MET A 160
ALA A 213
LEU A 211
ILE A 163
None
0.96A 2h77A-4g2nA:
undetectable
2h77A-4g2nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Acinetobacter
sp. ADP1)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
5 ILE A 196
ALA A  78
MET A  45
LEU A  36
ILE A  23
None
1.00A 2h77A-4gtnA:
undetectable
2h77A-4gtnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
5 ILE A   9
ALA A  26
ALA A 183
LEU A  71
PHE A  11
None
1.14A 2h77A-4jzyA:
undetectable
2h77A-4jzyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 ILE A 363
ALA A 388
ALA A  77
LEU A 346
ILE A  74
None
1.03A 2h77A-4kpgA:
undetectable
2h77A-4kpgA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB


(Staphylococcus
epidermidis)
PF00083
(Sugar_tr)
5 ILE A 248
ALA A 247
SER A 376
ILE A  56
PHE A 252
None
1.08A 2h77A-4ldsA:
undetectable
2h77A-4ldsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7


(Trypanosoma
brucei)
PF06325
(PrmA)
5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
None
1.13A 2h77A-4m38A:
undetectable
2h77A-4m38A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
5 ALA A 167
ARG A 153
ALA A 173
LEU A 223
ILE A 219
25L  A1000 ( 4.4A)
25L  A1000 (-3.9A)
None
None
None
1.16A 2h77A-4o1oA:
undetectable
2h77A-4o1oA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh7 ORNITHINE
CARBAMOYLTRANSFERASE


(Brucella
melitensis)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 ILE A 153
ALA A 296
LEU A  25
LEU A  13
PHE A 180
None
1.14A 2h77A-4oh7A:
undetectable
2h77A-4oh7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00565
(SNase)
5 ILE A 180
ALA A 210
LEU A 265
ILE A 263
HIS A 190
None
1.03A 2h77A-4qmgA:
undetectable
2h77A-4qmgA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN


(synthetic
construct)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ILE A 362
ALA A 363
LEU A 394
LEU A 406
ILE A 419
None
1.07A 2h77A-4r5dA:
undetectable
2h77A-4r5dA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN


(Nitratireductor
pacificus)
PF12838
(Fer4_7)
PF13486
(Dehalogenase)
5 ILE A 432
ALA A 365
ALA A 358
LEU A  46
ILE A 137
None
1.09A 2h77A-4rasA:
undetectable
2h77A-4rasA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1


(Pisum sativum)
PF00223
(PsaA_PsaB)
5 MET A 418
ALA A 356
SER A 359
LEU A 432
ILE A 349
None
BCR  A6007 ( 3.8A)
BCR  A6008 ( 3.7A)
CLA  A1122 ( 4.8A)
None
1.15A 2h77A-4rkuA:
undetectable
2h77A-4rkuA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL


(Homo sapiens)
PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
5 ALA A  70
ALA A  87
LEU A  89
LEU A  33
ILE A  96
None
1.14A 2h77A-4x4wA:
undetectable
2h77A-4x4wA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN


(Homo sapiens)
PF10421
(OAS1_C)
5 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
None
1.16A 2h77A-4xq7A:
undetectable
2h77A-4xq7A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfh DNA-BINDING PROTEIN
HU-ALPHA


(Escherichia
coli)
PF00216
(Bac_DNA_binding)
5 ILE A  32
ALA A  31
ALA A  24
ILE A  10
PHE A  50
None
1.08A 2h77A-4yfhA:
undetectable
2h77A-4yfhA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE


(Streptomyces
sp.)
no annotation 5 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
None
1.05A 2h77A-5a0kA:
undetectable
2h77A-5a0kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA


(Mycolicibacterium
smegmatis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 ILE A 273
ALA A 271
MET A 297
ALA A 361
LEU A 338
None
1.05A 2h77A-5ah4A:
undetectable
2h77A-5ah4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON


(Schizosaccharomyces
pombe)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
5 ILE I 414
ALA I 400
ALA I 365
LEU I 384
ILE I 362
None
1.09A 2h77A-5b04I:
undetectable
2h77A-5b04I:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u CONTACTIN-6

(Mus musculus)
PF13927
(Ig_3)
5 ILE B 237
ALA B 239
SER B 243
LEU B 282
ILE B 273
None
0.93A 2h77A-5e5uB:
undetectable
2h77A-5e5uB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6


(Mus musculus)
PF01663
(Phosphodiest)
5 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
None
0.91A 2h77A-5egeA:
undetectable
2h77A-5egeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE


(Trypanosoma
brucei)
PF06325
(PrmA)
5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
None
1.03A 2h77A-5ekuA:
undetectable
2h77A-5ekuA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elz TYPE II PANTOTHENATE
KINASE


(Staphylococcus
aureus)
PF03630
(Fumble)
5 ALA A 262
ALA A  65
LEU A  49
LEU A  39
ILE A  63
None
1.00A 2h77A-5elzA:
undetectable
2h77A-5elzA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itw DIHYDROANTICAPSIN
7-DEHYDROGENASE


(Bacillus
subtilis)
PF13561
(adh_short_C2)
5 ALA A  72
MET A 120
ALA A 124
LEU A  83
ILE A 136
None
1.09A 2h77A-5itwA:
undetectable
2h77A-5itwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus)
PF08534
(Redoxin)
5 ALA A  39
MET A 127
SER A 122
LEU A   8
ILE A   2
None
0.95A 2h77A-5k1gA:
undetectable
2h77A-5k1gA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Bacillus
subtilis)
PF03009
(GDPD)
5 ILE E 227
ALA E 223
MET E 216
MET E 219
LEU E 256
None
1.01A 2h77A-5t9cE:
undetectable
2h77A-5t9cE:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus)
PF00535
(Glycos_transf_2)
5 ILE A 192
ALA A 189
MET A 183
ALA A 235
ILE A 232
None
0.98A 2h77A-5tz8A:
undetectable
2h77A-5tz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 ILE A 170
ALA A 173
ALA A 146
LEU A  98
ILE A 137
None
1.02A 2h77A-5u4hA:
undetectable
2h77A-5u4hA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Campylobacter
jejuni)
PF00275
(EPSP_synthase)
5 ILE A 168
ALA A 171
ALA A 146
LEU A  98
ILE A 137
None
1.06A 2h77A-5ujsA:
undetectable
2h77A-5ujsA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri)
PF16363
(GDP_Man_Dehyd)
5 ILE A  82
ALA A  87
ALA A  50
LEU A  78
ILE A  41
None
1.07A 2h77A-5uzhA:
undetectable
2h77A-5uzhA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus)
PF12697
(Abhydrolase_6)
5 ILE A  99
ALA A 113
LEU A 123
SER A 122
PHE A  46
None
1.11A 2h77A-5v7oA:
undetectable
2h77A-5v7oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1


(Homo sapiens)
no annotation 5 ILE A  42
ALA A  43
ALA A  79
LEU A  83
LEU A  65
None
0.98A 2h77A-5whrA:
undetectable
2h77A-5whrA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9u THERMOSOME, ALPHA
SUBUNIT


(Carboxydothermus
hydrogenoformans)
no annotation 5 ALA A  92
ALA A 492
LEU A  99
LEU A 124
ILE A 493
None
1.16A 2h77A-5x9uA:
undetectable
2h77A-5x9uA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 ILE B 247
ALA B 229
ALA B 382
LEU B 249
LEU B 306
None
0.89A 2h77A-5xogB:
undetectable
2h77A-5xogB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xto FAD-LINKED
SULFHYDRYL OXIDASE


(Autographa
californica
multiple
nucleopolyhedrovirus)
PF05214
(Baculo_p33)
5 ALA A 202
ALA A 179
LEU A 216
ILE A 176
HIS A 172
None
1.01A 2h77A-5xtoA:
undetectable
2h77A-5xtoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Colwellia
psychrerythraea)
PF00275
(EPSP_synthase)
5 ILE A 312
ALA A 315
ALA A 247
SER A 245
ILE A 295
None
0.99A 2h77A-5xwbA:
undetectable
2h77A-5xwbA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa)
no annotation 5 ILE A 130
ALA A 205
LEU A 160
ILE A 201
PHE A 128
None
0.99A 2h77A-6amsA:
undetectable
2h77A-6amsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Moorella
thermoacetica)
no annotation 5 ILE A 566
ALA A 567
ALA A 575
LEU A 606
ILE A 576
None
1.14A 2h77A-6cipA:
undetectable
2h77A-6cipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Pseudomonas
putida)
no annotation 5 ILE A 172
ALA A 175
ALA A 147
LEU A  99
PHE A 159
None
1.08A 2h77A-6cn1A:
undetectable
2h77A-6cn1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gun -

(-)
no annotation 5 ILE A  87
ARG A 134
ALA A 164
LEU A 151
LEU A 107
None
1.16A 2h77A-6gunA:
undetectable
2h77A-6gunA:
undetectable