SIMILAR PATTERNS OF AMINO ACIDS FOR 2H4N_A_AZMA264_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  96
HIS A 119
VAL A 121
THR A 199
THR A 200
TRP A 209
 AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
 0.17A 2h4nA-1jd0A:
36.8		 2h4nA-1jd0A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		5 GLN A  69
HIS A  94
HIS A 111
THR A 177
THR A 178
 None
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
 0.88A 2h4nA-1kopA:
29.7		 2h4nA-1kopA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		7 GLN A  90
HIS A  94
HIS A 111
VAL A 113
THR A 177
THR A 178
TRP A 187
 None
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
None
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 0.50A 2h4nA-1kopA:
29.7		 2h4nA-1kopA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 GLN A  67
HIS A  96
HIS A 119
THR A 199
THR A 200
 None
ZN  A 601 (-3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
 0.83A 2h4nA-1rj6A:
37.4		 2h4nA-1rj6A:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  96
HIS A 119
VAL A 121
THR A 199
THR A 200
TRP A 209
 AZM  A 400 (-4.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-4.8A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
 0.33A 2h4nA-1rj6A:
37.4		 2h4nA-1rj6A:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  96
HIS A 119
VAL A 121
THR A 199
THR A 200
TRP A 209
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
None
 0.50A 2h4nA-1urtA:
37.1		 2h4nA-1urtA:
50.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		7 GLN A 113
HIS A 117
HIS A 135
VAL A 137
THR A 217
THR A 218
TRP A 227
 None
ZN  A 283 (-3.2A)
ZN  A 283 ( 3.1A)
ACY  A 279 ( 4.7A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
 0.40A 2h4nA-1y7wA:
26.2		 2h4nA-1y7wA:
31.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  92
HIS A  96
HIS A 119
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.6A)
None
 0.42A 2h4nA-2it4A:
41.0		 2h4nA-2it4A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  96
HIS A 119
VAL A 121
THR A 199
THR A 200
TRP A 209
 None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
ZN  A   1 ( 4.7A)
None
None
 0.39A 2h4nA-2zncA:
32.4		 2h4nA-2zncA:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 GLN A 115
HIS A 165
HIS A 182
THR A 260
THR A 261
 None
ZN  A 378 (-3.3A)
ZN  A 378 (-3.1A)
ZN  A 378 ( 4.5A)
None
 0.82A 2h4nA-3b1bA:
25.0		 2h4nA-3b1bA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 GLN A 161
HIS A 165
HIS A 182
VAL A 184
THR A 260
THR A 261
TRP A 270
 None
ZN  A 378 (-3.3A)
ZN  A 378 (-3.1A)
None
ZN  A 378 ( 4.5A)
None
None
 0.46A 2h4nA-3b1bA:
25.0		 2h4nA-3b1bA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 HIS A 165
HIS A  42
THR A 261
THR A 260
TRP A  40
 ZN  A 378 (-3.3A)
None
None
ZN  A 378 ( 4.5A)
None
 1.36A 2h4nA-3b1bA:
25.0		 2h4nA-3b1bA:
25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  93
HIS A  97
VAL A 122
PHE A 132
THR A 200
TRP A 210
 4MD  A 401 (-3.1A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 (-3.2A)
None
 0.67A 2h4nA-3da2A:
42.4		 2h4nA-3da2A:
59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  97
HIS A 120
VAL A 122
PHE A 132
THR A 200
TRP A 210
 ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 (-3.2A)
None
 0.23A 2h4nA-3da2A:
42.4		 2h4nA-3da2A:
59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A 109
HIS A 113
HIS A 138
VAL A 140
THR A 220
TRP A 230
 None
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
 0.77A 2h4nA-3fe4A:
31.6		 2h4nA-3fe4A:
33.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  67
HIS A  96
HIS A 119
THR A 199
THR A 200
 None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
 0.88A 2h4nA-3ml5A:
43.1		 2h4nA-3ml5A:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  96
HIS A 119
VAL A 121
PHE A 131
THR A 199
THR A 200
TRP A 209
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 0.43A 2h4nA-3ml5A:
43.1		 2h4nA-3ml5A:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  92
HIS A  96
VAL A 121
PHE A 131
THR A 199
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
 1.42A 2h4nA-3ml5A:
43.1		 2h4nA-3ml5A:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		5 GLN A 102
HIS A 125
HIS A 142
THR A 215
THR A 216
 None
ZN  A   1 (-3.3A)
ZN  A   1 ( 3.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
 0.92A 2h4nA-3q31A:
24.4		 2h4nA-3q31A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		7 GLN A 121
HIS A 125
HIS A 142
VAL A 144
THR A 215
THR A 216
TRP A 225
 MLT  A   3 (-3.9A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 3.2A)
None
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
 0.52A 2h4nA-3q31A:
24.4		 2h4nA-3q31A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  96
HIS A 119
VAL A 121
PHE A 130
THR A 198
THR A 199
TRP A 208
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
None
ZN  A 261 ( 4.4A)
None
None
 0.46A 2h4nA-3uyqA:
41.3		 2h4nA-3uyqA:
58.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		5 GLN A  67
HIS A  91
HIS A 108
THR A 174
THR A 175
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
 0.91A 2h4nA-4g7aA:
30.0		 2h4nA-4g7aA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		7 GLN A  87
HIS A  91
HIS A 108
VAL A 110
THR A 174
THR A 175
TRP A 184
 AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 (-4.7A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
 0.48A 2h4nA-4g7aA:
30.0		 2h4nA-4g7aA:
33.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n40 PROTEIN ECT2

(Homo sapiens) 		PF00533
(BRCT)
PF12738
(PTCB-BRCT) 		5 HIS A 279
VAL A 281
PHE A 250
THR A 262
TRP A 305
 None
 1.43A 2h4nA-4n40A:
undetectable		 2h4nA-4n40A:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  96
HIS A 119
VAL A 121
PHE A 131
THR A 199
THR A 200
TRP A 209
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
None
None
 0.37A 2h4nA-4qk3A:
43.8		 2h4nA-4qk3A:
95.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  92
HIS A  96
VAL A 121
PHE A 131
THR A 199
 None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
 1.45A 2h4nA-4qk3A:
43.8		 2h4nA-4qk3A:
95.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		7 GLN A 110
HIS A 114
HIS A 131
VAL A 133
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.45A 2h4nA-4uovA:
31.2		 2h4nA-4uovA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		5 GLN A  67
HIS A  91
HIS A 108
THR A 174
THR A 175
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 0.87A 2h4nA-4x5sA:
29.9		 2h4nA-4x5sA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		7 GLN A  87
HIS A  91
HIS A 108
VAL A 110
THR A 174
THR A 175
TRP A 184
 AZM  A 302 (-4.3A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 0.48A 2h4nA-4x5sA:
29.9		 2h4nA-4x5sA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		5 HIS A 112
HIS A 129
VAL A 131
THR A 191
TRP A 201
 ZN  A 301 (-3.4A)
ZN  A 301 ( 3.1A)
None
ZN  A 301 (-4.3A)
None
 0.33A 2h4nA-4xfwA:
26.6		 2h4nA-4xfwA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 GLN A 138
HIS A 162
HIS A 179
THR A 254
THR A 255
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
 0.89A 2h4nA-4xixA:
25.7		 2h4nA-4xixA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 GLN A 158
HIS A 162
HIS A 179
VAL A 181
THR A 254
THR A 255
TRP A 264
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
None
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 0.45A 2h4nA-4xixA:
25.7		 2h4nA-4xixA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		5 GLN A 143
HIS A 167
HIS A 184
THR A 252
THR A 253
 None
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.1A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
 1.01A 2h4nA-4xz5A:
29.8		 2h4nA-4xz5A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		7 GLN A 163
HIS A 167
HIS A 184
VAL A 186
THR A 252
THR A 253
TRP A 262
 None
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.1A)
None
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 0.49A 2h4nA-4xz5A:
29.8		 2h4nA-4xz5A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  67
HIS A  96
HIS A 119
THR A 199
THR A 200
 GOL  A 303 (-3.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
 0.88A 2h4nA-5cjfA:
37.0		 2h4nA-5cjfA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  96
HIS A 119
VAL A 121
THR A 199
THR A 200
TRP A 209
 GOL  A 303 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
 0.45A 2h4nA-5cjfA:
37.0		 2h4nA-5cjfA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 151
PHE A 187
THR A 257
THR A 258
TRP A 267
 None
 0.62A 2h4nA-5e5uA:
34.4		 2h4nA-5e5uA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		8 GLN X  91
HIS X  95
HIS X 118
VAL X 120
PHE X 129
THR X 197
THR X 198
TRP X 207
 None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.1A)
None
None
ZN  X 301 ( 4.4A)
None
None
 0.43A 2h4nA-5eztX:
44.1		 2h4nA-5eztX:
79.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		7 GLN A  94
HIS A  98
HIS A 115
VAL A 117
THR A 182
THR A 183
TRP A 192
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
None
 0.53A 2h4nA-5hpjA:
29.4		 2h4nA-5hpjA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  96
HIS A 119
VAL A 121
THR A 199
THR A 200
TRP A 209
 EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 0.39A 2h4nA-5jn9A:
33.3		 2h4nA-5jn9A:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 7 GLN A 115
HIS A 119
HIS A 136
VAL A 138
THR A 202
THR A 203
TRP A 212
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 301 (-4.4A)
None
None
 0.45A 2h4nA-6ekiA:
29.9		 2h4nA-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 7 GLN A  92
HIS A  96
HIS A 119
VAL A 121
THR A 199
THR A 200
TRP A 209
 V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 0.47A 2h4nA-6fe1A:
34.1		 2h4nA-6fe1A:
14.90