SIMILAR PATTERNS OF AMINO ACIDS FOR 2H42_C_VIAC903_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae)
PF00450
(Peptidase_S10)
3 ASN A 103
ILE A  26
MET A  29
None
0.80A 2h42C-1ac5A:
0.0
2h42C-1ac5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1


(Brevibacillus
brevis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
3 ASN A  71
ILE A  58
MET A 241
None
0.80A 2h42C-1amuA:
0.0
2h42C-1amuA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE


(Arthrobacter
sp. 1C)
PF02317
(Octopine_DH)
PF02558
(ApbA)
3 ASN A 277
ILE A 226
MET A 201
None
0.65A 2h42C-1bg6A:
0.0
2h42C-1bg6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byw PROTEIN (HUMAN ERG
POTASSIUM CHANNEL)


(Homo sapiens)
PF13426
(PAS_9)
3 ASN A  45
ILE A  42
MET A 124
None
0.75A 2h42C-1bywA:
undetectable
2h42C-1bywA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT


(Shigella
dysenteriae)
PF00161
(RIP)
3 ASN A 202
ILE A 174
MET A 192
None
0.69A 2h42C-1dm0A:
undetectable
2h42C-1dm0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef5 RGL

(Mus musculus)
PF00788
(RA)
3 ASN A 659
ILE A 654
MET A 683
None
0.84A 2h42C-1ef5A:
undetectable
2h42C-1ef5A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)


(Clostridium
pasteurianum)
PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4)
3 ASN A 216
ILE A 379
MET A 387
None
0.85A 2h42C-1fehA:
0.0
2h42C-1fehA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae)
PF00566
(RabGAP-TBC)
3 ASN A 381
ILE A 348
MET A 494
None
0.79A 2h42C-1fkmA:
0.0
2h42C-1fkmA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5n CHEMOTAXIS PROTEIN
CHEA


(Salmonella
enterica)
PF01627
(Hpt)
3 ASN A  89
ILE A 119
MET A  69
None
0.83A 2h42C-1i5nA:
0.5
2h42C-1i5nA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT


(Galdieria
partita)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
3 ASN A 207
ILE A 265
MET A 280
None
0.83A 2h42C-1iwaA:
0.0
2h42C-1iwaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE


(Neurospora
crassa)
PF10282
(Lactonase)
3 ASN A 205
ILE A 295
MET A 269
None
0.82A 2h42C-1jofA:
undetectable
2h42C-1jofA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3w EP-CADHERIN

(Xenopus laevis)
PF00028
(Cadherin)
3 ASN A  27
ILE A  24
MET A  92
None
0.75A 2h42C-1l3wA:
undetectable
2h42C-1l3wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN


(Enterovirus B)
PF00073
(Rhv)
3 ASN B 217
ILE B 205
MET B 202
None
0.82A 2h42C-1mqtB:
undetectable
2h42C-1mqtB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii)
PF00331
(Glyco_hydro_10)
3 ASN A 170
ILE A 198
MET A 187
None
0.81A 2h42C-1nq6A:
0.0
2h42C-1nq6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus)
PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N)
3 ASN X 499
ILE X 430
MET X 423
None
0.78A 2h42C-1ogoX:
undetectable
2h42C-1ogoX:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4i ANTIBODY VARIABLE
HEAVY CHAIN


(Mus musculus)
PF07686
(V-set)
3 ASN H  42
ILE H  21
MET H  93
None
0.71A 2h42C-1p4iH:
undetectable
2h42C-1p4iH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT


(Escherichia
coli)
PF00161
(RIP)
3 ASN A 201
ILE A 174
MET A 191
None
0.60A 2h42C-1r4pA:
undetectable
2h42C-1r4pA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0m ENDO-1,4-BETA-XYLANA
SE A


(Streptomyces
lividans)
PF00331
(Glyco_hydro_10)
3 ASN A 170
ILE A 199
MET A 188
None
0.82A 2h42C-1v0mA:
undetectable
2h42C-1v0mA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6u ENDO-1,4-BETA-D-XYLA
NASE


(Streptomyces
olivaceoviridis)
PF00331
(Glyco_hydro_10)
PF00652
(Ricin_B_lectin)
3 ASN A 170
ILE A 199
MET A 188
None
0.82A 2h42C-1v6uA:
undetectable
2h42C-1v6uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6y ENDO-1,4-BETA-D-XYLA
NASE AND
ENDO-1,4-BETA-XYLANA
SE B


(Cellulomonas
fimi;
Streptomyces
olivaceoviridis)
PF00331
(Glyco_hydro_10)
3 ASN A 170
ILE A 199
MET A 188
None
0.82A 2h42C-1v6yA:
undetectable
2h42C-1v6yA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT


(Corynebacterium
sp. U-96)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4)
3 ASN A 646
ILE A 636
MET A 689
None
0.83A 2h42C-1vrqA:
undetectable
2h42C-1vrqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE


(Acidaminococcus
fermentans)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
3 ASN A 146
ILE A 201
MET A 115
None
0.85A 2h42C-1xdwA:
undetectable
2h42C-1xdwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE


(Ruminiclostridium
thermocellum)
PF00331
(Glyco_hydro_10)
3 ASN A 687
ILE A 715
MET A 704
None
0.82A 2h42C-1xyzA:
undetectable
2h42C-1xyzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE


(Spinacia
oleracea)
PF01450
(IlvC)
PF07991
(IlvN)
3 ASN I 516
ILE I 436
MET I 433
None
0.75A 2h42C-1yveI:
undetectable
2h42C-1yveI:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII


(Thermococcus
kodakarensis)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing)
3 ASN A 349
ILE A 272
MET A 268
None
0.82A 2h42C-2cw7A:
undetectable
2h42C-2cw7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
3 ASN A 142
ILE A 145
MET A  96
MG  A 600 ( 2.7A)
None
None
0.84A 2h42C-2f9gA:
undetectable
2h42C-2f9gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN


(Pedobacter
heparinus)
PF07940
(Hepar_II_III)
PF16332
(DUF4962)
3 ASN A 669
ILE A 416
MET A 396
None
0.85A 2h42C-2fuqA:
undetectable
2h42C-2fuqA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC


(Lactococcus
lactis)
PF05147
(LANC_like)
3 ASN A 362
ILE A 324
MET A 318
None
0.86A 2h42C-2g02A:
undetectable
2h42C-2g02A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC


(Salmonella
enterica)
PF00291
(PALP)
3 ASN A 178
ILE A 309
MET A  30
None
0.76A 2h42C-2gn1A:
undetectable
2h42C-2gn1A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvi CONSERVED
HYPOTHETICAL PROTEIN


(Thermoplasma
acidophilum)
PF02663
(FmdE)
3 ASN A 105
ILE A 151
MET A  25
ACY  A 410 ( 3.5A)
None
None
0.85A 2h42C-2gviA:
undetectable
2h42C-2gviA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT


(Homo sapiens)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp)
3 ASN A 450
ILE A  59
MET A  38
None
0.85A 2h42C-2i7tA:
undetectable
2h42C-2i7tA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lp4 CHEMOTAXIS PROTEIN
CHEA


(Escherichia
coli)
PF01627
(Hpt)
PF09078
(CheY-binding)
3 ASN A  89
ILE A 119
MET A  69
None
0.83A 2h42C-2lp4A:
undetectable
2h42C-2lp4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE


(Arabidopsis
thaliana)
PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
3 ASN A 134
ILE A 142
MET A 108
None
0.76A 2h42C-2o7qA:
undetectable
2h42C-2o7qA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9r BETA-GLUCOSIDASE B

(Paenibacillus
polymyxa)
PF00232
(Glyco_hydro_1)
3 ASN A 163
ILE A 115
MET A  13
None
0.74A 2h42C-2o9rA:
undetectable
2h42C-2o9rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE


(Sinorhizobium
meliloti)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 ASN A   8
ILE A  37
MET A 113
None
0.82A 2h42C-2pgwA:
undetectable
2h42C-2pgwA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh5 MANNOSE-6-PHOSPHATE
ISOMERASE


(Helicobacter
pylori)
PF00483
(NTP_transferase)
3 ASN A  90
ILE A   6
MET A  98
None
0.84A 2h42C-2qh5A:
undetectable
2h42C-2qh5A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE


(Lactobacillus
delbrueckii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
3 ASN A 148
ILE A 203
MET A 116
None
0.80A 2h42C-2yq4A:
undetectable
2h42C-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
3 ASN A  34
ILE A  28
MET A 111
None
0.72A 2h42C-3b9eA:
undetectable
2h42C-3b9eA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY


(Acinetobacter
sp. ADP1)
no annotation 3 ASN A  61
ILE A 101
MET A  69
SO4  A 176 ( 4.9A)
None
None
0.61A 2h42C-3d3oA:
undetectable
2h42C-3d3oA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
gigas)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
3 ASN A 714
ILE A 644
MET A 672
None
0.85A 2h42C-3fahA:
undetectable
2h42C-3fahA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)


(Oryza sativa)
PF01450
(IlvC)
PF07991
(IlvN)
3 ASN A 516
ILE A 436
MET A 433
None
0.76A 2h42C-3fr8A:
undetectable
2h42C-3fr8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106


(Saccharomyces
cerevisiae)
PF08512
(Rtt106)
3 ASN A 120
ILE A 200
MET A 142
None
0.76A 2h42C-3fssA:
undetectable
2h42C-3fssA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY


(Strongyloides
stercoralis)
PF00104
(Hormone_recep)
3 ASN A 557
ILE A 621
MET A 625
None
DL7  A 200 ( 4.5A)
DL7  A 200 ( 4.7A)
0.71A 2h42C-3gyuA:
undetectable
2h42C-3gyuA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz7 UNCHARACTERIZED
PROTEIN


(Desulfitobacterium
hafniense)
PF01206
(TusA)
3 ASN A  44
ILE A  70
MET A  52
SX  A 101 ( 4.7A)
None
None
0.84A 2h42C-3hz7A:
undetectable
2h42C-3hz7A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2)
3 ASN A 599
ILE A 596
MET A 622
None
0.81A 2h42C-3ibjA:
38.5
2h42C-3ibjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Novosphingobium
aromaticivorans)
PF00106
(adh_short)
3 ASN A  91
ILE A 254
MET A 247
None
0.78A 2h42C-3ioyA:
undetectable
2h42C-3ioyA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1


(Cypovirus 1)
no annotation 3 ASN B 715
ILE B 409
MET B 413
None
0.69A 2h42C-3iz3B:
undetectable
2h42C-3iz3B:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE


(Bacteroides
thetaiotaomicron)
PF00809
(Pterin_bind)
3 ASN A 521
ILE A 540
MET A 589
None
0.68A 2h42C-3k13A:
undetectable
2h42C-3k13A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363


(Listeria
monocytogenes)
PF03575
(Peptidase_S51)
3 ASN A 162
ILE A 173
MET A 135
None
0.84A 2h42C-3l4eA:
undetectable
2h42C-3l4eA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5


(Homo sapiens)
PF01094
(ANF_receptor)
3 ASN A  88
ILE A  35
MET A 429
None
0.66A 2h42C-3lmkA:
undetectable
2h42C-3lmkA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Legionella
pneumophila)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 ASN A  51
ILE A 158
MET A  81
None
0.72A 2h42C-3pfeA:
undetectable
2h42C-3pfeA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE


(Campylobacter
jejuni)
PF00162
(PGK)
3 ASN A 320
ILE A 317
MET A 369
None
0.85A 2h42C-3q3vA:
undetectable
2h42C-3q3vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus)
PF00008
(EGF)
PF02210
(Laminin_G_2)
3 ASN A 980
ILE A1000
MET A 934
None
0.84A 2h42C-3qcwA:
undetectable
2h42C-3qcwA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqr NON-LEGUME
HEMOGLOBIN


(Parasponia
andersonii)
PF00042
(Globin)
3 ASN A  28
ILE A 126
MET A 133
None
0.65A 2h42C-3qqrA:
undetectable
2h42C-3qqrA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzy BACULOVIRUS
SULFHYDRYL OXIDASE
AC92


(Autographa
californica
multiple
nucleopolyhedrovirus)
PF05214
(Baculo_p33)
3 ASN A 226
ILE A 169
MET A 113
FAD  A 334 (-2.9A)
None
FAD  A 334 ( 3.7A)
0.68A 2h42C-3qzyA:
undetectable
2h42C-3qzyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
3 ASN A 202
ILE A 113
MET A 223
None
0.79A 2h42C-3stjA:
undetectable
2h42C-3stjA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl1 POLYKETIDE CYCLASE

(Streptomyces
coelicolor)
PF03364
(Polyketide_cyc)
3 ASN A  20
ILE A  11
MET A 106
None
0.74A 2h42C-3tl1A:
undetectable
2h42C-3tl1A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
3 ASN A 172
ILE A 166
MET A 212
None
0.84A 2h42C-3vasA:
undetectable
2h42C-3vasA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens)
PF00004
(AAA)
PF09336
(Vps4_C)
3 ASN A 580
ILE A 562
MET A 573
None
0.76A 2h42C-3vfdA:
undetectable
2h42C-3vfdA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN


(Streptomyces
thermoviolaceus)
PF01547
(SBP_bac_1)
3 ASN A 327
ILE A  98
MET A  74
BXP  A 601 (-2.9A)
None
None
0.70A 2h42C-3vxcA:
undetectable
2h42C-3vxcA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
3 ASN A 492
ILE A 489
MET A 656
None
0.82A 2h42C-3wkyA:
undetectable
2h42C-3wkyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7


(Caenorhabditis
elegans)
PF13649
(Methyltransf_25)
3 ASN A 638
ILE A 548
MET A 577
None
0.82A 2h42C-3wstA:
undetectable
2h42C-3wstA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A


(Streptomyces
sp.)
PF00331
(Glyco_hydro_10)
3 ASN A 207
ILE A 235
MET A 224
None
0.85A 2h42C-3wufA:
undetectable
2h42C-3wufA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,


(Homo sapiens)
PF00850
(Hist_deacetyl)
3 ASN A 128
ILE A 125
MET A  45
None
0.79A 2h42C-4a69A:
undetectable
2h42C-4a69A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8j ELONGATOR COMPLEX
PROTEIN 5


(Saccharomyces
cerevisiae)
PF10483
(Elong_Iki1)
3 ASN B 110
ILE B  58
MET B 131
None
0.75A 2h42C-4a8jB:
undetectable
2h42C-4a8jB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG


(Escherichia
coli;
Homo sapiens)
PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8)
3 ASN A 639
ILE A 671
MET A 669
None
0.80A 2h42C-4blaA:
undetectable
2h42C-4blaA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens)
PF00809
(Pterin_bind)
PF02574
(S-methyl_trans)
3 ASN A 539
ILE A 558
MET A 607
None
0.74A 2h42C-4cczA:
undetectable
2h42C-4cczA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN


(Bacteroides
eggerthii)
no annotation 3 ASN A 627
ILE A 577
MET A 411
None
0.77A 2h42C-4ecoA:
undetectable
2h42C-4ecoA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5


(Saccharomyces
cerevisiae)
PF10483
(Elong_Iki1)
3 ASN B 110
ILE B  58
MET B 131
None
0.72A 2h42C-4ejsB:
undetectable
2h42C-4ejsB:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN


(Homo sapiens)
PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452)
3 ASN A 519
ILE A 422
MET A 484
None
0.72A 2h42C-4eljA:
undetectable
2h42C-4eljA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5


(Schizosaccharomyces
pombe)
PF01423
(LSM)
3 ASN A  18
ILE A  42
MET A  63
None
0.82A 2h42C-4emkA:
undetectable
2h42C-4emkA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN


(Plasmodium
falciparum)
PF00092
(VWA)
3 ASN A 125
ILE A  59
MET A  53
None
0.85A 2h42C-4f1kA:
undetectable
2h42C-4f1kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3


(Legionella
pneumophila)
no annotation 3 ASN A 662
ILE A 201
MET A 248
None
0.83A 2h42C-4fyeA:
undetectable
2h42C-4fyeA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE


(Thermococcus
kodakarensis)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
3 ASN A 172
ILE A 197
MET A 261
None
AMP  A 601 (-4.2A)
AMP  A 601 (-4.2A)
0.66A 2h42C-4ga6A:
undetectable
2h42C-4ga6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gps KLLA0E02245P

(Kluyveromyces
lactis)
no annotation 3 ASN A 284
ILE A 333
MET A 294
None
0.67A 2h42C-4gpsA:
undetectable
2h42C-4gpsA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE


(Coxiella
burnetii)
PF00162
(PGK)
3 ASN A 315
ILE A 312
MET A 364
ADP  A 402 (-3.1A)
None
None
0.79A 2h42C-4ng4A:
undetectable
2h42C-4ng4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT


(Methanocaldococcus
jannaschii)
PF00330
(Aconitase)
3 ASN A 163
ILE A 227
MET A 205
None
0.71A 2h42C-4nqyA:
undetectable
2h42C-4nqyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
3 ASN A 551
ILE A 261
MET A 256
None
0.78A 2h42C-4okdA:
undetectable
2h42C-4okdA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24


(Actinoplanes
teichomyceticus)
no annotation 3 ASN A 286
ILE A 149
MET A 161
None
None
TEC  A 404 (-4.3A)
0.62A 2h42C-4q38A:
undetectable
2h42C-4q38A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9v SIALYLTRANSFERASE
0160


(Photobacterium
damselae)
PF11477
(PM0188)
3 ASN A 204
ILE A 209
MET A 177
None
0.80A 2h42C-4r9vA:
undetectable
2h42C-4r9vA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE


(Bacillus
subtilis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
3 ASN A 386
ILE A 380
MET A 405
None
0.77A 2h42C-4rjkA:
undetectable
2h42C-4rjkA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE


(Synechocystis
sp. PCC 6803)
no annotation 3 ASN B  82
ILE B 129
MET B 157
None
0.83A 2h42C-4rziB:
undetectable
2h42C-4rziB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uei STEROL CARRIER
PROTEIN
2/3-OXOACYL-COA
THIOLASE


(Helicoverpa
armigera)
PF02036
(SCP2)
3 ASN A  80
ILE A  68
MET A  29
None
0.58A 2h42C-4ueiA:
undetectable
2h42C-4ueiA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3


(Bifidobacterium
adolescentis)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
3 ASN A 409
ILE A 289
MET A 443
None
0.79A 2h42C-4ye5A:
undetectable
2h42C-4ye5A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhw U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3


(Saccharomyces
cerevisiae)
PF06544
(DUF1115)
3 ASN A 346
ILE A 380
MET A 442
None
None
G  E  86 ( 3.8A)
0.84A 2h42C-4yhwA:
undetectable
2h42C-4yhwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yte H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ0715


(Methanocaldococcus
jannaschii)
no annotation 3 ASN A 176
ILE A  84
MET A 143
None
0.62A 2h42C-4yteA:
undetectable
2h42C-4yteA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqd T-BOX TRANSCRIPTION
FACTOR TBX5


(Homo sapiens)
PF00907
(T-box)
3 ASN A 230
ILE A 222
MET A  74
None
0.57A 2h42C-5bqdA:
undetectable
2h42C-5bqdA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Pseudothermotoga
lettingae)
PF13416
(SBP_bac_8)
3 ASN A 151
ILE A 169
MET A 258
None
0.71A 2h42C-5ci5A:
undetectable
2h42C-5ci5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2


(Rickettsia
typhi)
PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31)
3 ASN A 304
ILE A 276
MET A 257
None
0.79A 2h42C-5dooA:
undetectable
2h42C-5dooA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1


(Rickettsia
prowazekii)
PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31)
3 ASN A 332
ILE A 304
MET A 285
None
0.76A 2h42C-5dpdA:
undetectable
2h42C-5dpdA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1x TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY


(Dehalococcoides
mccartyi)
PF12802
(MarR_2)
3 ASN A  16
ILE A  24
MET A 123
None
0.77A 2h42C-5e1xA:
undetectable
2h42C-5e1xA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee4 HPUA

(Kingella
denitrificans)
PF16960
(HpuA)
3 ASN A 297
ILE A 225
MET A 237
None
0.72A 2h42C-5ee4A:
undetectable
2h42C-5ee4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE


([Eubacterium]
rectale)
PF00078
(RVT_1)
3 ASN A 239
ILE A 140
MET A 259
None
0.81A 2h42C-5hhlA:
undetectable
2h42C-5hhlA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1


(Avena sativa;
Homo sapiens)
PF00071
(Ras)
PF13426
(PAS_9)
3 ASN A 185
ILE A  64
MET A 146
None
0.85A 2h42C-5hzhA:
undetectable
2h42C-5hzhA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irr SEPTIN-LIKE PROTEIN

(Chlamydomonas
reinhardtii)
PF00735
(Septin)
3 ASN A 285
ILE A 297
MET A 248
None
0.80A 2h42C-5irrA:
undetectable
2h42C-5irrA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN


(Flavobacterium
johnsoniae)
PF12771
(SusD-like_2)
3 ASN A 120
ILE A 108
MET A 128
None
0.80A 2h42C-5j5uA:
undetectable
2h42C-5j5uA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE


(Mycobacterium
tuberculosis)
PF12697
(Abhydrolase_6)
3 ASN A 169
ILE A 184
MET A 177
None
None
6OT  A 301 ( 4.9A)
0.82A 2h42C-5jzbA:
undetectable
2h42C-5jzbA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE


(Shewanella
oneidensis)
PF01041
(DegT_DnrJ_EryC1)
3 ASN A 311
ILE A 386
MET A 269
None
0.75A 2h42C-5k8bA:
undetectable
2h42C-5k8bA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena)
no annotation 3 ASN A 170
ILE A 198
MET A 187
None
0.77A 2h42C-5m0kA:
undetectable
2h42C-5m0kA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2


(Sus scrofa)
no annotation 3 ASN A 380
ILE A 384
MET A 452
None
0.83A 2h42C-5mpmA:
undetectable
2h42C-5mpmA:
14.15