SIMILAR PATTERNS OF AMINO ACIDS FOR 2H42_B_VIAB902_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 13pk | 3-PHOSPHOGLYCERATEKINASE (Trypanosomabrucei) |
PF00162(PGK) | 5 | HIS A 62ALA A 175ILE A 180VAL A 134LEU A 130 | 3PG A 423 (-4.1A)NoneNoneNoneNone | 1.11A | 2h42B-13pkA:undetectable | 2h42B-13pkA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0n | XANTHAN LYASE (Bacillus sp.GL1) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 5 | HIS A 323ALA A 372ILE A 375VAL A 326ILE A 289 | None | 1.15A | 2h42B-1j0nA:undetectable | 2h42B-1j0nA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l2q | MONOMETHYLAMINEMETHYLTRANSFERASE (Methanosarcinabarkeri) |
PF05369(MtmB) | 5 | ALA A 242ILE A 243ALA A 285LEU A 70PHE A 12 | None | 0.97A | 2h42B-1l2qA:undetectable | 2h42B-1l2qA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nf1 | PROTEIN(NEUROFIBROMIN) (Homo sapiens) |
PF00616(RasGAP) | 5 | ALA A1429ILE A1428LEU A1300ILE A1397PHE A1347 | None | 1.05A | 2h42B-1nf1A:undetectable | 2h42B-1nf1A:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1od5 | GLYCININ (Glycine max) |
PF00190(Cupin_1) | 5 | ALA A 336ILE A 335VAL A 72ALA A 143ILE A 69 | NoneNoneNoneCO3 A 496 ( 4.6A)None | 1.11A | 2h42B-1od5A:undetectable | 2h42B-1od5A:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qmo | MANNOSE BINDINGLECTIN, FRIL (Lablabpurpureus) |
PF00139(Lectin_legB) | 5 | ALA E 180ILE A 72VAL E 137LEU A 108ILE A 92 | None | 1.12A | 2h42B-1qmoE:undetectable | 2h42B-1qmoE:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3d | SERINEACETYLTRANSFERASE (Escherichiacoli) |
PF00132(Hexapep)PF06426(SATase_N) | 5 | ILE A 170VAL A 180ALA A 206ILE A 220MET A 201 | None | 1.04A | 2h42B-1t3dA:undetectable | 2h42B-1t3dA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vzo | RIBOSOMAL PROTEIN S6KINASE ALPHA 5 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 286ILE A 290VAL A 154LEU A 139ILE A 161 | None | 1.08A | 2h42B-1vzoA:undetectable | 2h42B-1vzoA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xpg | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 5 | ASN A 601ILE A 631ALA A 607ILE A 576PHE A 581 | None | 1.06A | 2h42B-1xpgA:undetectable | 2h42B-1xpgA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zan | FAB AD11 HEAVY CHAINFAB AD11 LIGHT CHAIN (Rattusnorvegicus) |
PF07654(C1-set)PF07686(V-set) | 5 | TYR L 71ALA L 25ILE L 2ALA L 34LEU H 100 | None | 1.15A | 2h42B-1zanL:undetectable | 2h42B-1zanL:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkl | HIGH-AFFINITYCAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 7A (Homo sapiens) |
PF00233(PDEase_I) | 6 | TYR A 211HIS A 212VAL A 380ILE A 409GLN A 413PHE A 416 | IBM A 503 (-4.6A)NoneIBM A 503 (-4.7A)NoneIBM A 503 (-3.0A)IBM A 503 (-3.4A) | 0.68A | 2h42B-1zklA:34.8 | 2h42B-1zklA:28.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkl | HIGH-AFFINITYCAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 7A (Homo sapiens) |
PF00233(PDEase_I) | 5 | TYR A 211HIS A 212VAL A 380LEU A 401GLN A 413 | IBM A 503 (-4.6A)NoneIBM A 503 (-4.7A)NoneIBM A 503 (-3.0A) | 0.92A | 2h42B-1zklA:34.8 | 2h42B-1zklA:28.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zzm | PUTATIVEDEOXYRIBONUCLEASEYJJV (Escherichiacoli) |
PF01026(TatD_DNase) | 5 | ASN A 257ALA A 53VAL A 93ALA A 94ILE A 131 | None | 1.11A | 2h42B-1zzmA:undetectable | 2h42B-1zzmA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1p | HYPOTHETICAL PROTEINYHEL (Escherichiacoli) |
PF04077(DsrH) | 5 | ALA C 63ILE C 62VAL C 34ALA C 37ILE C 70 | None | 1.11A | 2h42B-2d1pC:undetectable | 2h42B-2d1pC:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2div | TRNA SELENOCYSTEINEASSOCIATED PROTEIN (Homo sapiens) |
PF00076(RRM_1) | 5 | ASN A 89ALA A 52ILE A 43ILE A 26PHE A 56 | None | 1.06A | 2h42B-2divA:undetectable | 2h42B-2divA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eg1 | NITROGEN REGULATORYPROTEIN P-II (Aquifexaeolicus) |
PF00543(P-II) | 5 | ALA A 6ILE A 91VAL A 16ALA A 19ILE A 23 | None | 1.15A | 2h42B-2eg1A:undetectable | 2h42B-2eg1A:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iq7 | ENDOPOLYGALACTURONASE (Colletotrichumlupini) |
PF00295(Glyco_hydro_28) | 5 | VAL A 51ALA A 31LEU A 46ILE A 35MET A 59 | None | 1.06A | 2h42B-2iq7A:undetectable | 2h42B-2iq7A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jah | CLAVULANIC ACIDDEHYDROGENASE (Streptomycesclavuligerus) |
PF00106(adh_short) | 5 | ALA A 10ILE A 12VAL A 228ALA A 227ILE A 183 | None | 1.10A | 2h42B-2jahA:undetectable | 2h42B-2jahA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kpt | PUTATIVE SECRETEDPROTEIN (Corynebacteriumglutamicum) |
PF04536(TPM_phosphatase) | 5 | ALA A 75ILE A 76ALA A 148LEU A 121ILE A 130 | None | 1.00A | 2h42B-2kptA:undetectable | 2h42B-2kptA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m3k | MINOR PILIN COMP (Neisseriameningitidis) |
PF16732(ComP_DUS) | 5 | ALA A 73ILE A 74VAL A 12ALA A 15ILE A 45 | None | 1.09A | 2h42B-2m3kA:undetectable | 2h42B-2m3kA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q27 | OXALYL-COADECARBOXYLASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 240VAL A 277ALA A 222ILE A 251PHE A 234 | None | 0.94A | 2h42B-2q27A:undetectable | 2h42B-2q27A:20.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r8q | CLASS IPHOSPHODIESTERASEPDEB1 (Leishmaniamajor) |
PF00233(PDEase_I) | 5 | TYR A 680HIS A 681VAL A 853GLN A 887PHE A 890 | IBM A 3 ( 4.7A)IBM A 3 ( 4.8A)IBM A 3 ( 4.8A)IBM A 3 (-3.3A)IBM A 3 (-3.6A) | 0.55A | 2h42B-2r8qA:38.1 | 2h42B-2r8qA:31.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wy0 | ANGIOTENSINOGEN (Mus musculus) |
PF00079(Serpin) | 5 | ILE C 432ALA C 104LEU C 150ILE C 173GLN C 171 | None | 1.05A | 2h42B-2wy0C:undetectable | 2h42B-2wy0C:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhl | BOTULINUM NEUROTOXINB HEAVY CHAIN (Clostridiumbotulinum) |
PF07952(Toxin_trans) | 5 | TYR B 638ALA B 782ILE B 783VAL B 636LEU B 666 | None | 1.15A | 2h42B-2xhlB:undetectable | 2h42B-2xhlB:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ya2 | PUTATIVE ALKALINEAMYLOPULLULANASE (Streptococcuspneumoniae) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | ALA A 162ILE A 164VAL A 140LEU A 254ILE A 178 | None | 1.09A | 2h42B-2ya2A:undetectable | 2h42B-2ya2A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yoc | PULLULANASE (Klebsiellaoxytoca) |
PF02922(CBM_48)PF03714(PUD)PF11852(DUF3372) | 5 | ALA A 647ILE A 646ALA A 673LEU A 712PHE A 664 | None | 1.16A | 2h42B-2yocA:undetectable | 2h42B-2yocA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzr | PYRIDOXALBIOSYNTHESIS LYASEPDXS (Methanocaldococcusjannaschii) |
PF01680(SOR_SNZ)PF05690(ThiG) | 5 | ASN A 26ALA A 38ILE A 75VAL A 24LEU A 65 | None | 1.06A | 2h42B-2yzrA:undetectable | 2h42B-2yzrA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zuk | ALPHA-AMINO-EPSILON-CAPROLACTAM RACEMASE (Achromobacterobae) |
PF00202(Aminotran_3) | 5 | ALA A 280ILE A 284VAL A 236ALA A 202ILE A 233 | None | 1.07A | 2h42B-2zukA:undetectable | 2h42B-2zukA:24.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2r | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I) | 10 | TYR A 612HIS A 613ALA A 767ILE A 768VAL A 782ALA A 783ILE A 813MET A 816GLN A 817PHE A 820 | VDN A 1 (-4.8A)VDN A 1 (-4.3A)VDN A 1 ( 3.8A)VDN A 1 (-4.5A)VDN A 1 ( 4.7A)VDN A 1 ( 4.0A)VDN A 1 ( 4.2A)VDN A 1 (-4.0A)VDN A 1 (-3.0A)VDN A 1 (-3.6A) | 0.36A | 2h42B-3b2rA:46.2 | 2h42B-3b2rA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bc9 | ALPHA AMYLASE,CATALYTIC REGION (Halothermothrixorenii) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ALA A 214ILE A 215VAL A 167ALA A 166PHE A 344 | None | 1.07A | 2h42B-3bc9A:undetectable | 2h42B-3bc9A:19.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3bjc | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I) | 10 | TYR A 612HIS A 613ALA A 767ILE A 768VAL A 782ALA A 783ILE A 813MET A 816GLN A 817PHE A 820 | None MG A 877 (-4.4A)WAN A 901 ( 3.9A)WAN A 901 ( 4.9A)WAN A 901 ( 4.9A)WAN A 901 (-3.6A)WAN A 901 ( 4.3A)WAN A 901 (-4.3A)WAN A 901 (-3.1A)WAN A 901 (-3.7A) | 0.47A | 2h42B-3bjcA:48.2 | 2h42B-3bjcA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bww | PROTEIN OF UNKNOWNFUNCTIONDUF692/COG3220 (Histophilussomni) |
PF05114(DUF692) | 5 | TYR A 201HIS A 203ILE A 56LEU A 61ILE A 79 | None FE A 308 (-3.4A)NoneNoneNone | 1.15A | 2h42B-3bwwA:undetectable | 2h42B-3bwwA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxj | RASGTPASE-ACTIVATINGPROTEIN SYNGAP (Rattusnorvegicus) |
PF00168(C2)PF00616(RasGAP) | 5 | ALA A 435ILE A 439LEU A 710ILE A 396PHE A 405 | None | 1.10A | 2h42B-3bxjA:undetectable | 2h42B-3bxjA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c1o | EUGENOL SYNTHASE (Clarkia breweri) |
PF05368(NmrA) | 5 | ALA A 137ILE A 138ALA A 99LEU A 72PHE A 106 | None | 1.12A | 2h42B-3c1oA:undetectable | 2h42B-3c1oA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwf | 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 (Cavia porcellus) |
PF00106(adh_short) | 5 | TYR A 123ASN A 143ILE A 46LEU A 190ILE A 214 | NAP A 301 (-4.8A)NoneNAP A 301 (-3.8A)NoneNone | 1.10A | 2h42B-3dwfA:undetectable | 2h42B-3dwfA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecn | HIGH AFFINITYCAMP-SPECIFIC ANDIBMX-INSENSITIVE3',5'-CYCLICPHOSPHODIESTERASE 8A (Homo sapiens) |
PF00233(PDEase_I) | 5 | TYR A 555HIS A 556ILE A 774GLN A 778PHE A 781 | NoneNoneNoneIBM A 3 (-3.4A)IBM A 3 (-3.5A) | 0.46A | 2h42B-3ecnA:34.8 | 2h42B-3ecnA:25.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gy9 | GCN5-RELATEDN-ACETYLTRANSFERASE (Exiguobacteriumsibiricum) |
PF13673(Acetyltransf_10) | 5 | ALA A 53ILE A 5LEU A 125ILE A 78MET A 101 | None | 1.06A | 2h42B-3gy9A:undetectable | 2h42B-3gy9A:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpf | MUCONATECYCLOISOMERASE (Oceanobacillusiheyensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 278ILE A 272ILE A 257GLN A 253PHE A 250 | None | 1.15A | 2h42B-3hpfA:undetectable | 2h42B-3hpfA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibj | CGMP-DEPENDENT3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I)PF01590(GAF)PF13185(GAF_2) | 5 | TYR A 655HIS A 656ILE A 855GLN A 859PHE A 862 | None | 0.58A | 2h42B-3ibjA:38.8 | 2h42B-3ibjA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd9 | COENZYME A DISULFIDEREDUCTASE (Pyrococcushorikoshii) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ASN A 311ALA A 282ILE A 262ALA A 18ILE A 8 | None | 0.91A | 2h42B-3kd9A:undetectable | 2h42B-3kd9A:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksd | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE1 (Staphylococcusaureus) |
no annotation | 5 | TYR Q 320ALA Q 121ILE Q 119ALA Q 17ILE Q 7 | NAD Q 337 ( 3.8A)NAD Q 337 (-3.2A)NoneNoneNone | 0.99A | 2h42B-3ksdQ:undetectable | 2h42B-3ksdQ:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kws | PUTATIVE SUGARISOMERASE (Parabacteroidesdistasonis) |
PF01261(AP_endonuc_2) | 5 | ALA A 60ILE A 59VAL A 77LEU A 51PHE A 286 | None | 1.01A | 2h42B-3kwsA:undetectable | 2h42B-3kwsA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 272VAL A 190ALA A 192LEU A 350ILE A 219 | NoneNoneNoneGOL A 365 (-3.9A)None | 1.11A | 2h42B-3nuuA:undetectable | 2h42B-3nuuA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r11 | ENZYME OF ENOLASESUPERFAMILY (Francisellaphilomiragia) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 286ILE A 291VAL A 248ILE A 228MET A 231 | None | 1.13A | 2h42B-3r11A:undetectable | 2h42B-3r11A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r2g | INOSINE5'-MONOPHOSPHATEDEHYDROGENASE (Legionellapneumophila) |
PF00478(IMPDH) | 5 | ALA A 70VAL A 203ALA A 204LEU A 218ILE A 208 | None | 1.07A | 2h42B-3r2gA:undetectable | 2h42B-3r2gA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3svi | TYPE III EFFECTORHOPAB2 (Pseudomonassyringae groupgenomosp. 3) |
no annotation | 5 | ALA A 211ALA A 158LEU A 178MET A 166PHE A 167 | None | 1.05A | 2h42B-3sviA:undetectable | 2h42B-3sviA:14.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tjy | EFFECTOR PROTEINHOPAB3 (Pseudomonassyringae groupgenomosp. 3) |
no annotation | 5 | ALA A 211ALA A 158LEU A 178MET A 166PHE A 167 | None | 1.07A | 2h42B-3tjyA:undetectable | 2h42B-3tjyA:14.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tk1 | MEMBRANEATPASE/PROTEINKINASE (Mycolicibacteriumthermoresistibile) |
PF03308(ArgK) | 5 | HIS A 54ALA A 84ALA A 142LEU A 42ILE A 12 | None | 1.15A | 2h42B-3tk1A:undetectable | 2h42B-3tk1A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ua4 | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Caenorhabditiselegans) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 5 | ILE A 689VAL A 536ALA A 643ILE A 539MET A 640 | None | 1.10A | 2h42B-3ua4A:undetectable | 2h42B-3ua4A:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uel | POLY(ADP-RIBOSE)GLYCOHYDROLASE (Rattusnorvegicus) |
PF05028(PARG_cat) | 5 | ALA A 844ILE A 820VAL A 861ALA A 862ILE A 722 | NoneNoneNoneNoneA1R A1001 (-4.2A) | 1.09A | 2h42B-3uelA:undetectable | 2h42B-3uelA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uj2 | ENOLASE 1 (Anaerostipescaccae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 6 | ALA A 220ILE A 221VAL A 164ALA A 245LEU A 272ILE A 288 | None | 1.18A | 2h42B-3uj2A:undetectable | 2h42B-3uj2A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uwd | PHOSPHOGLYCERATEKINASE (Bacillusanthracis) |
PF00162(PGK) | 5 | HIS A 231ALA A 222ILE A 217ILE A 302PHE A 260 | None | 0.99A | 2h42B-3uwdA:undetectable | 2h42B-3uwdA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) |
PF00233(PDEase_I) | 5 | TYR A 367HIS A 368ALA A 524GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneNoneWYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.69A | 2h42B-3v94A:34.2 | 2h42B-3v94A:27.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrd | FLAVOCYTOCHROME CFLAVIN SUBUNIT (Thermochromatiumtepidum) |
PF07992(Pyr_redox_2)PF09242(FCSD-flav_bind) | 5 | ALA B 153ILE B 151ALA B 127LEU B 136ILE B 49 | None | 1.14A | 2h42B-3vrdB:undetectable | 2h42B-3vrdB:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zxy | SUBTILISIN-LIKEPROTEIN (Prochlorondidemni) |
PF00082(Peptidase_S8) | 5 | ILE A 65VAL A 227ALA A 228LEU A 169ILE A 115 | None | 1.15A | 2h42B-3zxyA:undetectable | 2h42B-3zxyA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a9a | RIBOSOME-INTERACTINGGTPASE 1 (Saccharomycescerevisiae) |
PF01926(MMR_HSR1)PF02824(TGS)PF16897(MMR_HSR1_Xtn) | 5 | TYR A 213ALA A 36VAL A 209ALA A 208LEU A 201 | None | 1.10A | 2h42B-4a9aA:undetectable | 2h42B-4a9aA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c8g | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Burkholderiacenocepacia) |
PF02542(YgbB) | 5 | ALA A 152ILE A 46VAL A 100ALA A 133ILE A 111 | NoneNoneNoneC5P A1163 (-3.6A)None | 1.16A | 2h42B-4c8gA:undetectable | 2h42B-4c8gA:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dje | CORRINOID/IRON-SULFUR PROTEIN SMALLSUBUNIT (Moorellathermoacetica) |
PF03599(CdhD) | 5 | ASN D 163ILE D 298ALA D 185LEU D 172ILE D 211 | None | 1.12A | 2h42B-4djeD:undetectable | 2h42B-4djeD:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f55 | SPORE CORTEX-LYTICENZYME (Bacillus cereus) |
PF07486(Hydrolase_2) | 5 | ASN A 209ALA A 219ILE A 220ALA A 153ILE A 190 | None | 1.06A | 2h42B-4f55A:undetectable | 2h42B-4f55A:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f55 | SPORE CORTEX-LYTICENZYME (Bacillus cereus) |
PF07486(Hydrolase_2) | 5 | ASN A 209ALA A 219VAL A 154ALA A 153ILE A 190 | None | 1.13A | 2h42B-4f55A:undetectable | 2h42B-4f55A:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fc2 | POLY(ADP-RIBOSE)GLYCOHYDROLASE (Mus musculus) |
PF05028(PARG_cat) | 5 | ALA A 841ILE A 817VAL A 858ALA A 859ILE A 719 | None | 1.09A | 2h42B-4fc2A:undetectable | 2h42B-4fc2A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fet | SPORE CORTEX-LYTICENZYME PREPEPTIDE (Bacillusanthracis) |
no annotation | 5 | ASN B 203ALA B 213VAL B 148ALA B 147ILE B 184 | None | 1.14A | 2h42B-4fetB:undetectable | 2h42B-4fetB:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwt | ELONGATION FACTORTS, ELONGATIONFACTOR TU, LINKER, QBETA REPLICASE (Escherichiacoli;Escherichiavirus Qbeta) |
PF00009(GTP_EFTU)PF00889(EF_TS)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2)PF03431(RNA_replicase_B) | 5 | ASN A 558ALA A 490ILE A 491VAL A 516ILE A 521 | None | 0.91A | 2h42B-4fwtA:undetectable | 2h42B-4fwtA:14.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4htz | CGMP-DEPENDENT3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I) | 5 | TYR A 655HIS A 656ILE A 855GLN A 859PHE A 862 | None | 0.42A | 2h42B-4htzA:40.3 | 2h42B-4htzA:35.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvl | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumthermoresistibile) |
PF00082(Peptidase_S8) | 5 | ALA A 357ILE A 360VAL A 226ALA A 225ILE A 199 | IMD A 510 (-3.5A)NoneIMD A 510 (-4.8A)NoneNone | 0.91A | 2h42B-4hvlA:undetectable | 2h42B-4hvlA:20.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4i15 | CLASS 1PHOSPHODIESTERASEPDEB1 (Trypanosomabrucei) |
PF00233(PDEase_I) | 5 | TYR A 668HIS A 669VAL A 840GLN A 874PHE A 877 | None | 0.66A | 2h42B-4i15A:37.1 | 2h42B-4i15A:31.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4id0 | GLUTATHIONES-TRANSFERASE-LIKEPROTEIN YIBF (Pseudomonasfluorescens) |
PF13410(GST_C_2)PF13417(GST_N_3) | 5 | ALA A 146ILE A 147VAL A 161ALA A 162ILE A 191 | None | 0.80A | 2h42B-4id0A:undetectable | 2h42B-4id0A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpg | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | ALA A 357ILE A 360VAL A 226ALA A 225ILE A 199 | None | 0.95A | 2h42B-4kpgA:undetectable | 2h42B-4kpgA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpn | NUCLEOSIDEN-RIBOHYDROLASE 1 (Physcomitrellapatens) |
PF01156(IU_nuc_hydro) | 5 | ALA A 200ILE A 202VAL A 151ALA A 150LEU A 86 | None | 1.05A | 2h42B-4kpnA:undetectable | 2h42B-4kpnA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4li3 | CYSTEINE SYNTHASE (Haemophilusinfluenzae) |
PF00291(PALP) | 5 | TYR X 79ILE X 45VAL X 80ALA X 81ILE X 65 | NoneLLP X 42 ( 4.0A)NoneNoneNone | 1.05A | 2h42B-4li3X:undetectable | 2h42B-4li3X:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m1z | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | ALA A 357ILE A 360VAL A 226ALA A 225ILE A 199 | None | 0.95A | 2h42B-4m1zA:undetectable | 2h42B-4m1zA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n03 | ABC-TYPEBRANCHED-CHAIN AMINOACID TRANSPORTSYSTEMS PERIPLASMICCOMPONENT-LIKEPROTEIN (Thermomonosporacurvata) |
PF13458(Peripla_BP_6) | 5 | ALA A 296ILE A 390LEU A 213ILE A 183MET A 178 | None | 1.12A | 2h42B-4n03A:undetectable | 2h42B-4n03A:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5j | UNCHARACTERIZEDPROTEIN (Helicobacterpylori) |
no annotation | 5 | ALA A 247ILE A 251VAL A 89ALA A 88ILE A 349 | None | 1.11A | 2h42B-4o5jA:undetectable | 2h42B-4o5jA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oxr | MANGANESE ABCTRANSPORTER,PERIPLASMIC-BINDINGPROTEIN SITA (Staphylococcuspseudintermedius) |
PF01297(ZnuA) | 5 | TYR A 167ALA A 51ILE A 53ALA A 155ILE A 113 | None | 0.87A | 2h42B-4oxrA:undetectable | 2h42B-4oxrA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pe6 | PUTATIVE ABCTRANSPORTER (Thermobisporabispora) |
PF13407(Peripla_BP_4) | 5 | ALA A 238ILE A 240VAL A 284ALA A 285LEU A 319 | None | 1.12A | 2h42B-4pe6A:undetectable | 2h42B-4pe6A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r8f | VACUOLARAMINOPEPTIDASE 1 (Saccharomycescerevisiae) |
PF02127(Peptidase_M18) | 5 | ALA A 275ILE A 71ALA A 267LEU A 291ILE A 85 | None | 1.08A | 2h42B-4r8fA:undetectable | 2h42B-4r8fA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rae | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF00155(Aminotran_1_2) | 5 | ALA A 198ILE A 171VAL A 161ALA A 160ILE A 142 | None | 1.13A | 2h42B-4raeA:undetectable | 2h42B-4raeA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvx | ACYL-[ACYL-CARRIER-PROTEIN]DEHYDROGENASE MBTN (Mycobacteriumtuberculosis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ALA A 120ILE A 118VAL A 181ALA A 221LEU A 102 | FDA A 402 (-3.3A)FDA A 402 (-4.9A)NoneNoneNone | 1.10A | 2h42B-4xvxA:undetectable | 2h42B-4xvxA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzr | POLYKETIDEBIOSYNTHESISCYTOCHROME P450 PKSS (Bacillussubtilis) |
PF00067(p450) | 5 | HIS A 342ASN A 340ALA A 358ALA A 277ILE A 274 | HIS A 342 ( 1.0A)ASN A 340 ( 0.6A)ALA A 358 (-0.0A)ALA A 277 ( 0.0A)ILE A 274 ( 0.4A) | 1.08A | 2h42B-4yzrA:undetectable | 2h42B-4yzrA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zmu | DIGUANYLATE CYCLASE (Pseudomonasaeruginosa) |
PF00990(GGDEF)PF01590(GAF) | 5 | ASN A 148ALA A 125ILE A 81ALA A 154ILE A 49 | None | 0.98A | 2h42B-4zmuA:undetectable | 2h42B-4zmuA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3y | THERMOLYSIN (Bacillusthermoproteolyticus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 5 | ALA A 309ILE A 244ALA A 286LEU A 275PHE A 267 | None | 1.12A | 2h42B-5a3yA:undetectable | 2h42B-5a3yA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aga | DNA POLYMERASE THETA (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | TYR A 239ALA A 544ILE A 539ALA A 554LEU A 519 | None | 1.03A | 2h42B-5agaA:undetectable | 2h42B-5agaA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b58 | PUTATIVE HEMIN ABCTRANSPORT SYSTEM,MEMBRANE PROTEIN (Burkholderiacenocepacia) |
PF01032(FecCD) | 5 | ALA A 182ILE A 181VAL A 161ALA A 158LEU A 268 | None | 0.93A | 2h42B-5b58A:undetectable | 2h42B-5b58A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e68 | S-RIBOSYLHOMOCYSTEINE LYASE (Salmonellaenterica) |
PF02664(LuxS) | 5 | HIS A 11ALA A 22VAL A 9ALA A 160LEU A 166 | None | 1.08A | 2h42B-5e68A:undetectable | 2h42B-5e68A:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fxn | THERMOLYSIN (Bacillusthermoproteolyticus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 5 | ALA A 309ILE A 244ALA A 286LEU A 275PHE A 267 | None | 1.10A | 2h42B-5fxnA:undetectable | 2h42B-5fxnA:19.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h2r | PHOSPHODIESTERASE (Trypanosomabrucei) |
no annotation | 5 | TYR A 668HIS A 669VAL A 841GLN A 875PHE A 878 | LLN A1003 ( 4.8A)NoneLLN A1003 (-4.6A)LLN A1003 (-3.0A)LLN A1003 (-3.8A) | 0.55A | 2h42B-5h2rA:37.6 | 2h42B-5h2rA:32.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jh8 | PROBABLE CHITINASE (Chromobacteriumviolaceum) |
PF00704(Glyco_hydro_18) | 5 | ALA A 50ILE A 51VAL A 26ALA A 25PHE A 103 | NoneMLZ A 101 ( 4.2A)NoneNoneMLZ A 101 ( 2.9A) | 1.03A | 2h42B-5jh8A:undetectable | 2h42B-5jh8A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ld5 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Atopobiumvaginae) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | TYR A 340ALA A 138ILE A 136ALA A 32ILE A 22 | NAD A 401 (-3.8A)NAD A 401 (-3.4A)NoneNoneNone | 1.00A | 2h42B-5ld5A:undetectable | 2h42B-5ld5A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ng7 | EPOXIDE HYDROLASE (metagenome) |
no annotation | 5 | TYR A 148ALA A 243ILE A 244VAL A 149MET A 133 | None | 1.06A | 2h42B-5ng7A:undetectable | 2h42B-5ng7A:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o3m | PROTOCATECHUATEDECARBOXYLASE (Klebsiellapneumoniae) |
PF01977(UbiD) | 5 | ALA A 224VAL A 236ALA A 237LEU A 86ILE A 216 | None | 1.10A | 2h42B-5o3mA:undetectable | 2h42B-5o3mA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oms | CYTOCHROME P450 (Amycolatopsissp. ATCC 39116) |
no annotation | 5 | ALA A 79ILE A 80ALA A 295LEU A 319ILE A 292 | NoneHEM A 501 (-4.4A)261 A 502 ( 3.9A)NoneHEM A 501 ( 3.5A) | 0.95A | 2h42B-5omsA:undetectable | 2h42B-5omsA:12.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5q | SHORT-CHAINDEHYDROGENASE/REDUCTASESDR:GLUCOSE/RIBITOLDEHYDROGENASE (Brucellaabortus) |
PF13561(adh_short_C2) | 5 | ALA A 62ILE A 60ALA A 125ILE A 84MET A 78 | None | 0.89A | 2h42B-5t5qA:undetectable | 2h42B-5t5qA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usd | PEPTIDASE S66 (Bacillusanthracis) |
PF02016(Peptidase_S66) | 5 | ALA A 196ILE A 314VAL A 257LEU A 248ILE A 201 | None | 1.11A | 2h42B-5usdA:undetectable | 2h42B-5usdA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vhf | 26S PROTEASOMENON-ATPASEREGULATORY SUBUNIT 3 (Homo sapiens) |
PF01399(PCI)PF08375(Rpn3_C) | 5 | HIS V 453ALA V 434ILE V 437ALA V 449ILE V 447 | None | 1.14A | 2h42B-5vhfV:undetectable | 2h42B-5vhfV:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vmt | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Neisseriagonorrhoeae) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | TYR A 319ALA A 121ILE A 119ALA A 17ILE A 7 | NAD A 401 (-3.5A)NAD A 401 (-3.2A)NoneNoneNone | 1.00A | 2h42B-5vmtA:undetectable | 2h42B-5vmtA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vyw | PYRUVATE CARBOXYLASE (Lactococcuslactis) |
PF00289(Biotin_carb_N)PF00682(HMGL-like)PF02436(PYC_OADA)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | ALA A 70ILE A 66ALA A 97LEU A 107PHE A 91 | None | 1.13A | 2h42B-5vywA:undetectable | 2h42B-5vywA:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y37 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Streptococcusagalactiae) |
no annotation | 5 | TYR A 324ALA A 126ILE A 124ALA A 21ILE A 11 | NAD A 401 (-3.6A)NAD A 401 (-3.3A)NoneNoneNone | 1.04A | 2h42B-5y37A:undetectable | 2h42B-5y37A:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bz0 | DIHYDROLIPOYLDEHYDROGENASE (Acinetobacterbaumannii) |
no annotation | 5 | ALA A 24ILE A 21VAL A 337ALA A 336ILE A 316 | None | 1.13A | 2h42B-6bz0A:undetectable | 2h42B-6bz0A:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d7t | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 6 (Homo sapiens) |
no annotation | 5 | ASN A 464ILE A 420ILE A 480GLN A 483PHE A 487 | None | 1.15A | 2h42B-6d7tA:undetectable | 2h42B-6d7tA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gw5 | - (-) |
no annotation | 5 | ALA A 243ILE A 247VAL A 89ALA A 88ILE A 345 | None | 1.09A | 2h42B-6gw5A:undetectable | 2h42B-6gw5A:undetectable |