SIMILAR PATTERNS OF AMINO ACIDS FOR 2GVC_B_MMZB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b43 PROTEIN (FEN-1)

(Pyrococcus
furiosus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ASN A 186
TYR A 173
SER A 170
 None
 0.94A 2gvcB-1b43A:
0.0		 2gvcB-1b43A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		3 ASN A 200
TYR A  91
SER A 180
 None
 0.94A 2gvcB-1h4pA:
0.0		 2gvcB-1h4pA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE

(Candida
albicans) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 ASN A 201
TYR A 210
SER A 171
 None
 0.94A 2gvcB-1iylA:
0.0		 2gvcB-1iylA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1

(Streptomyces
coelicolor) 		PF01183
(Glyco_hydro_25) 		3 ASN A 214
TYR A  53
SER A  87
 None
 0.63A 2gvcB-1jfxA:
0.0		 2gvcB-1jfxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASN A 311
TYR A 345
SER A 350
 None
 0.94A 2gvcB-1rvkA:
0.4		 2gvcB-1rvkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		3 ASN A 168
TYR A 157
SER A 163
 None
 0.68A 2gvcB-1sqgA:
1.8		 2gvcB-1sqgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02233
(PNTB) 		3 ASN A 130
TYR A 179
SER A 135
 NDP  A 300 (-4.3A)
None
None
 0.89A 2gvcB-1u31A:
3.2		 2gvcB-1u31A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		3 ASN A 225
TYR A 106
SER A 135
 None
 0.87A 2gvcB-1ve3A:
1.8		 2gvcB-1ve3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wt9 ANTICOAGULANT
PROTEIN-B

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 ASN B 103
TYR B  98
SER B 101
 None
 0.93A 2gvcB-1wt9B:
undetectable		 2gvcB-1wt9B:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT

(Pseudomonas
putida) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 ASN A 164
TYR A 172
SER A 156
 FAD  A 599 (-3.6A)
FAD  A 599 (-4.3A)
None
 0.49A 2gvcB-1wveA:
undetectable		 2gvcB-1wveA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2w COAGULATION FACTOR
IX/FACTOR X-BINDING
PROTEIN B CHAIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 ASN B 103
TYR B  98
SER B 101
 None
 0.87A 2gvcB-1x2wB:
undetectable		 2gvcB-1x2wB:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybi NON-TOXIN
HAEMAGGLUTININ HA34

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		3 ASN A 210
TYR A 237
SER A 226
 None
 0.84A 2gvcB-1ybiA:
undetectable		 2gvcB-1ybiA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		3 ASN A 124
TYR A 149
SER A  97
 FMN  A2606 ( 4.5A)
FMN  A2606 (-4.0A)
None
 0.92A 2gvcB-1yw1A:
undetectable		 2gvcB-1yw1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		3 ASN A 240
TYR A 209
SER A 243
 None
 0.74A 2gvcB-2dpmA:
undetectable		 2gvcB-2dpmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ASN A 191
TYR A 297
SER A 185
 None
 0.94A 2gvcB-2dpnA:
undetectable		 2gvcB-2dpnA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		3 ASN A  91
TYR A 176
SER A 223
 NDP  A 501 ( 3.5A)
NDP  A 501 ( 3.8A)
NDP  A 501 (-2.8A)
 0.65A 2gvcB-2gv8A:
65.0		 2gvcB-2gv8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihx NUCLEOCAPSID (NC)
PROTEIN

(Rous sarcoma
virus) 		PF00098
(zf-CCHC) 		3 ASN A  42
TYR A  22
SER A  40
 None
 0.86A 2gvcB-2ihxA:
undetectable		 2gvcB-2ihxA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASN A 127
TYR A 337
SER A 112
 HEM  A 486 (-3.4A)
HEM  A 486 (-4.1A)
HEM  A 486 ( 3.8A)
 0.92A 2gvcB-2isaA:
undetectable		 2gvcB-2isaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m07 OUTER MEMBRANE
PROTEIN X

(Escherichia
coli) 		PF13505
(OMP_b-brl) 		3 ASN A  19
TYR A  62
SER A  12
 None
 0.73A 2gvcB-2m07A:
undetectable		 2gvcB-2m07A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2l OUTER MEMBRANE
PROTEIN X

(Yersinia pestis) 		PF13505
(OMP_b-brl) 		3 ASN A  30
TYR A  88
SER A   7
 None
 0.70A 2gvcB-2n2lA:
undetectable		 2gvcB-2n2lA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		3 ASN A 301
TYR A 292
SER A 263
 None
 0.93A 2gvcB-2nxxA:
undetectable		 2gvcB-2nxxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3

(Murid
gammaherpesvirus
4) 		PF09213
(M3) 		3 ASN A 102
TYR A 300
SER A 313
 None
 0.90A 2gvcB-2nyzA:
undetectable		 2gvcB-2nyzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 ASN G1696
TYR G1681
SER G1705
 None
 0.87A 2gvcB-2uv8G:
0.0		 2gvcB-2uv8G:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 ASN A 189
TYR A 222
SER A 336
 None
 0.64A 2gvcB-2vz9A:
undetectable		 2gvcB-2vz9A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASN A 467
TYR A 361
SER A 340
 None
 0.85A 2gvcB-2wd9A:
undetectable		 2gvcB-2wd9A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 ASN A 465
TYR A  76
SER A 202
 None
 0.94A 2gvcB-2wyaA:
undetectable		 2gvcB-2wyaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 ASN A 585
TYR A 782
SER A 580
 None
 0.73A 2gvcB-2x05A:
undetectable		 2gvcB-2x05A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y38 LAMININ SUBUNIT
ALPHA-5

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		3 ASN A 359
TYR A 251
SER A  49
 None
NAG  A3001 (-3.8A)
None
 0.94A 2gvcB-2y38A:
undetectable		 2gvcB-2y38A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 ASN A 212
TYR A 535
SER A 540
 None
 0.74A 2gvcB-2ycbA:
undetectable		 2gvcB-2ycbA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yf0 MYOTUBULARIN-RELATED
PROTEIN 6

(Homo sapiens) 		PF06602
(Myotub-related) 		3 ASN A 329
TYR A 192
SER A 331
 None
 0.85A 2gvcB-2yf0A:
undetectable		 2gvcB-2yf0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjz METALLOREDUCTASE
STEAP4

(Rattus
norvegicus) 		PF03807
(F420_oxidored) 		3 ASN A 107
TYR A  86
SER A 116
 None
 0.92A 2gvcB-2yjzA:
2.6		 2gvcB-2yjzA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		3 ASN A 249
TYR A 256
SER A 288
 SDT  A 702 (-2.9A)
None
None
 0.92A 2gvcB-2zi8A:
undetectable		 2gvcB-2zi8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASN A  46
TYR A  50
SER A  84
 None
 0.93A 2gvcB-3a9vA:
undetectable		 2gvcB-3a9vA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		3 ASN A 460
TYR A 334
SER A  38
 None
HBO  A 900 ( 4.9A)
None
 0.89A 2gvcB-3aivA:
undetectable		 2gvcB-3aivA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al5 JMJC
DOMAIN-CONTAINING
PROTEIN C2ORF60

(Homo sapiens) 		PF13621
(Cupin_8) 		3 ASN A 166
TYR A 264
SER A 145
 None
 0.91A 2gvcB-3al5A:
undetectable		 2gvcB-3al5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alt LECTIN CEL-IV,
C-TYPE

(Cucumaria
echinata) 		PF00059
(Lectin_C) 		3 ASN A 115
TYR A 129
SER A 111
 MLB  A 301 (-2.6A)
MLB  A 301 ( 4.2A)
None
 0.82A 2gvcB-3altA:
undetectable		 2gvcB-3altA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9n ALKANE MONOOXYGENASE

(Geobacillus
thermodenitrificans) 		PF00296
(Bac_luciferase) 		3 ASN A 133
TYR A 158
SER A 106
 None
 0.61A 2gvcB-3b9nA:
undetectable		 2gvcB-3b9nA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwg UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YYDK

(Bacillus
subtilis) 		PF00392
(GntR)
PF07702
(UTRA) 		3 ASN A 111
TYR A 200
SER A 203
 None
 0.89A 2gvcB-3bwgA:
undetectable		 2gvcB-3bwgA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 ASN A 361
TYR A 307
SER A 304
 None
 0.75A 2gvcB-3ciyA:
undetectable		 2gvcB-3ciyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE

(Staphylococcus
aureus) 		PF13738
(Pyr_redox_3) 		3 ASN A  59
TYR A  92
SER A  55
 None
 0.80A 2gvcB-3d1cA:
15.7		 2gvcB-3d1cA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		3 ASN A 309
TYR A  79
SER A  23
 None
 0.92A 2gvcB-3dhuA:
undetectable		 2gvcB-3dhuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN
THYROTROPIN RECEPTOR

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF13306
(LRR_5) 		3 ASN B  58
TYR C  82
SER B 100
 None
 0.94A 2gvcB-3g04B:
undetectable		 2gvcB-3g04B:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ASN A 126
TYR A 167
SER A 130
 None
 0.90A 2gvcB-3gm8A:
undetectable		 2gvcB-3gm8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		3 ASN A 145
TYR A  16
SER A 147
 None
PMV  A 400 (-3.6A)
PMV  A 400 (-2.7A)
 0.86A 2gvcB-3gonA:
undetectable		 2gvcB-3gonA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ASN A 189
TYR A 222
SER A 336
 None
 0.62A 2gvcB-3hhdA:
undetectable		 2gvcB-3hhdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		3 ASN A  36
TYR A  48
SER A   7
 None
 0.85A 2gvcB-3jsaA:
undetectable		 2gvcB-3jsaA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER

(Staphylococcus
aureus) 		PF04069
(OpuAC) 		3 ASN A 281
TYR A  94
SER A 221
 ACT  A 323 (-3.8A)
PGE  A 321 (-3.8A)
None
 0.91A 2gvcB-3o66A:
undetectable		 2gvcB-3o66A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oes GTPASE RHEBL1

(Homo sapiens) 		PF00071
(Ras) 		3 ASN A  41
TYR A  35
SER A  21
 None
GNP  A 201 (-4.5A)
GNP  A 201 (-2.6A)
 0.94A 2gvcB-3oesA:
undetectable		 2gvcB-3oesA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN

([Eubacterium]
rectale) 		PF16472
(DUF5050) 		3 ASN A 298
TYR A  87
SER A  59
 None
 0.90A 2gvcB-3s25A:
undetectable		 2gvcB-3s25A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upu ATP-DEPENDENT DNA
HELICASE DDA

(Escherichia
virus T4) 		PF13604
(AAA_30) 		3 ASN A  31
TYR A 426
SER A 118
 None
 0.86A 2gvcB-3upuA:
undetectable		 2gvcB-3upuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v68 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF10869
(DUF2666) 		3 ASN A 171
TYR A 224
SER A  34
 None
MPD  A 253 (-4.7A)
None
 0.94A 2gvcB-3v68A:
undetectable		 2gvcB-3v68A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		3 ASN A  25
TYR A 211
SER A  29
 None
 0.87A 2gvcB-3vi1A:
undetectable		 2gvcB-3vi1A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		3 ASN A 356
TYR A 350
SER A 333
 None
 0.93A 2gvcB-3vsmA:
undetectable		 2gvcB-3vsmA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 ASN A 214
TYR A 166
SER A 189
 None
 0.94A 2gvcB-3zyjA:
undetectable		 2gvcB-3zyjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		3 ASN A 426
TYR A 166
SER A 429
 None
 0.92A 2gvcB-4ainA:
undetectable		 2gvcB-4ainA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayh METAL-BINDING
PROTEIN YODA

(Salmonella
enterica) 		PF09223
(ZinT) 		3 ASN A 160
TYR A 105
SER A 133
 None
 0.89A 2gvcB-4ayhA:
undetectable		 2gvcB-4ayhA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4beq ALANINE RACEMASE 2

(Vibrio cholerae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASN A 250
TYR A 275
SER A 245
 None
None
PLP  A1350 (-2.5A)
 0.87A 2gvcB-4beqA:
undetectable		 2gvcB-4beqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqa UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735)
PF13385
(Laminin_G_3) 		3 ASN A  42
TYR A  83
SER A 133
 None
 0.82A 2gvcB-4dqaA:
undetectable		 2gvcB-4dqaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ASN A 215
TYR A 321
SER A 209
 None
 0.94A 2gvcB-4e1jA:
undetectable		 2gvcB-4e1jA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e37 CATALASE

(Pseudomonas
aeruginosa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASN A 128
TYR A 338
SER A 113
 HEM  A 500 (-3.1A)
HEM  A 500 (-4.0A)
HEM  A 500 ( 3.7A)
 0.88A 2gvcB-4e37A:
undetectable		 2gvcB-4e37A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eei ADENYLOSUCCINATE
LYASE

(Francisella
tularensis) 		PF00206
(Lyase_1) 		3 ASN A  18
TYR A 112
SER A  11
 None
EDO  A 505 (-3.6A)
None
 0.90A 2gvcB-4eeiA:
undetectable		 2gvcB-4eeiA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eps HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF13149
(Mfa_like_1) 		3 ASN A 476
TYR A 509
SER A 470
 None
 0.65A 2gvcB-4epsA:
undetectable		 2gvcB-4epsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4q BEL-BETA TREFOIL

(Boletus edulis) 		no annotation 3 ASN A  91
TYR A 110
SER A  73
 None
 0.85A 2gvcB-4i4qA:
undetectable		 2gvcB-4i4qA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASN A  51
TYR A 113
SER A  48
 None
 0.90A 2gvcB-4j0mA:
undetectable		 2gvcB-4j0mA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica) 		PF02917
(Pertussis_S1)
PF03372
(Exo_endo_phos) 		3 ASN G 102
TYR F  27
SER G 139
 None
GOL  G 301 ( 4.7A)
None
 0.83A 2gvcB-4k6lG:
undetectable		 2gvcB-4k6lG:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		3 ASN A 232
TYR A 259
SER A 234
 None
 0.92A 2gvcB-4kv7A:
undetectable		 2gvcB-4kv7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11

(Homo sapiens) 		PF06337
(DUSP)
PF14836
(Ubiquitin_3) 		3 ASN A  44
TYR A 122
SER A  37
 None
 0.69A 2gvcB-4melA:
undetectable		 2gvcB-4melA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		3 ASN A 341
TYR A 415
SER A 289
 None
None
GLN  A 501 ( 4.3A)
 0.41A 2gvcB-4n0iA:
undetectable		 2gvcB-4n0iA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 3 ASN A  72
TYR A  56
SER A  63
 None
 0.86A 2gvcB-4n5aA:
undetectable		 2gvcB-4n5aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		3 ASN A  29
TYR A 400
SER A 487
 None
None
GOL  A 601 ( 2.7A)
 0.93A 2gvcB-4oerA:
undetectable		 2gvcB-4oerA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		3 ASN A 117
TYR A  44
SER A  51
 None
 0.75A 2gvcB-4pucA:
undetectable		 2gvcB-4pucA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		3 ASN A 323
TYR A  31
SER A  57
 None
 0.93A 2gvcB-4pwvA:
undetectable		 2gvcB-4pwvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC

(Bordetella
pertussis) 		PF03865
(ShlB)
PF08479
(POTRA_2)
PF17287
(POTRA_3) 		3 ASN A 339
TYR A 353
SER A 307
 None
 0.92A 2gvcB-4ql0A:
undetectable		 2gvcB-4ql0A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16819
(DUF5074)
PF16820
(PKD_3) 		3 ASN A  76
TYR A 197
SER A 150
 ACT  A 504 ( 3.8A)
None
None
 0.92A 2gvcB-4r5oA:
undetectable		 2gvcB-4r5oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		3 ASN A  96
TYR A 142
SER A  89
 None
 0.83A 2gvcB-4yzzA:
undetectable		 2gvcB-4yzzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		3 ASN A   8
TYR B 254
SER A 334
 None
 0.81A 2gvcB-5bn4A:
undetectable		 2gvcB-5bn4A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		3 ASN A 232
TYR A 446
SER A 198
 None
 0.88A 2gvcB-5czyA:
undetectable		 2gvcB-5czyA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		3 ASN A 123
TYR A 147
SER A  96
 PE4  A 501 (-3.2A)
SO4  A 502 (-4.4A)
None
 0.85A 2gvcB-5dqpA:
1.1		 2gvcB-5dqpA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96

(Vicugna pacos;
Xenopus
tropicalis) 		PF04096
(Nucleoporin2)
PF07686
(V-set) 		3 ASN B 771
TYR A 115
SER A 105
 None
 0.94A 2gvcB-5e0qB:
undetectable		 2gvcB-5e0qB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		3 ASN A 608
TYR A 833
SER A 617
 None
 0.85A 2gvcB-5fbuA:
undetectable		 2gvcB-5fbuA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuc INTERLEUKIN-6
RECEPTOR SUBUNIT
ALPHA, INTERLEUKIN-6
RECEPTOR
VHH6

(Camelus
dromedarius;
Homo sapiens) 		PF07686
(V-set)
PF09240
(IL6Ra-bind) 		3 ASN C 226
TYR E  59
SER C 228
 NAG  C1299 (-1.8A)
None
None
 0.86A 2gvcB-5fucC:
undetectable		 2gvcB-5fucC:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		3 ASN A 243
TYR A 173
SER A 237
 None
None
ACT  A 310 (-4.8A)
 0.90A 2gvcB-5hw3A:
undetectable		 2gvcB-5hw3A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 ASN A 453
TYR A  53
SER A 566
 FE  A1001 (-3.4A)
None
None
 0.92A 2gvcB-5medA:
undetectable		 2gvcB-5medA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 3 ASN B 189
TYR B 222
SER B 336
 None
 0.71A 2gvcB-5my0B:
undetectable		 2gvcB-5my0B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 3 ASN A  77
TYR A 106
SER A 113
 None
 0.91A 2gvcB-5na7A:
undetectable		 2gvcB-5na7A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC

(Bacillus
subtilis) 		no annotation 3 ASN A 250
TYR A  63
SER A 190
 None
1Y8  A 301 ( 3.6A)
None
 0.86A 2gvcB-5nxyA:
undetectable		 2gvcB-5nxyA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		3 ASN A 135
TYR A 160
SER A 108
 None
 0.82A 2gvcB-5tlcA:
undetectable		 2gvcB-5tlcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF08412
(Ion_trans_N) 		3 ASN A 107
TYR A 144
SER A 139
 None
 0.88A 2gvcB-5u6oA:
undetectable		 2gvcB-5u6oA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v38 HCHA

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 ASN A1230
TYR A1259
SER A1256
 None
 0.93A 2gvcB-5v38A:
undetectable		 2gvcB-5v38A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4z RIBOFLAVIN LYASE

(Herbiconiux) 		no annotation 3 ASN A 137
TYR A 162
SER A 110
 None
 0.80A 2gvcB-5w4zA:
undetectable		 2gvcB-5w4zA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 3 ASN A 867
TYR A 669
SER A 863
 None
 0.93A 2gvcB-5wtkA:
undetectable		 2gvcB-5wtkA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 3 ASN C1645
TYR C1628
SER C1635
 None
 0.90A 2gvcB-5x6oC:
undetectable		 2gvcB-5x6oC:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn4 ANTI-CRISPR ACRIIA4

(Listeria
monocytogenes) 		no annotation 3 ASN X  61
TYR X  41
SER X  57
 None
 0.87A 2gvcB-5xn4X:
undetectable		 2gvcB-5xn4X:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
PERMEAE

(Streptococcus
pneumoniae) 		no annotation 3 ASN M  56
TYR M 140
SER M 236
 None
 0.83A 2gvcB-5xu1M:
undetectable		 2gvcB-5xu1M:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 3 ASN 2 227
TYR 2 233
SER 2  98
 None
 0.90A 2gvcB-5zvs2:
undetectable		 2gvcB-5zvs2:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 3 ASN A 168
TYR A 797
SER A 356
 None
 0.66A 2gvcB-6d4jA:
undetectable		 2gvcB-6d4jA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 3 ASN A 571
TYR A 766
SER A 644
 G39  A 908 (-4.5A)
G39  A 908 (-4.6A)
G39  A 908 ( 3.8A)
 0.78A 2gvcB-6eksA:
undetectable		 2gvcB-6eksA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 3 ASN A  45
TYR A  76
SER A  85
 None
 0.90A 2gvcB-6ekvA:
undetectable		 2gvcB-6ekvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 3 ASN A 189
TYR A 319
SER A 118
 None
None
CJ2  A 402 ( 3.7A)
 0.93A 2gvcB-6f2uA:
undetectable		 2gvcB-6f2uA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 3 ASN A  28
TYR A  73
SER A 629
 None
 0.89A 2gvcB-6f8zA:
undetectable		 2gvcB-6f8zA:
11.94